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1,200 results on '"Dirks, Peter"'

201. Frequent Amplification of a chr19q13.41 MicroRNA Polycistron in Aggressive Primitive Neuroectodermal Brain Tumors

Author

Li, Meihua, Lee, Kyle F., Lu, Yuntao, Clarke, Ian, Shih, David, Eberhart, Charles, Collins, V. Peter, Van Meter, Tim, Picard, Daniel, Zhou, Limei, Boutros, Paul C., Modena, Piergiorgio, Liang, Muh-Lii, Scherer, Steve W., Bouffet, Eric, Rutka, James T., Pomeroy, Scott L., Lau, Ching C., Taylor, Michael D., Gajjar, Amar, Dirks, Peter B., Hawkins, Cynthia E., and Huang, Annie

Published
2009
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215. Preservation of endocrine function after Ommaya reservoir insertion in children with cystic craniopharyngioma.

Author

Lohkamp, Laura-Nanna, Kulkarni, Abhaya V., Drake, James M., Rutka, James T., Dirks, Peter B., Taylor, Michael, Ibrahim, George M., Hamilton, Jill, and Bartels, Ute K.

Abstract

Introduction: Children with craniopharyngiomas (CP) can experience significant morbidities caused by extensive surgery and/or radiation. Ommaya reservoir insertion (ORI) into cystic CP represents a minimally invasive approach allowing immediate decompression and aims to avoid additional injuries. The purpose of this study was to determine the surgical outcome and relevance of upfront ORI (± intracystic treatment) for preservation of endocrine function. Methods: We performed a retrospective chart review of children with CP treated at the Hospital for Sick Children between 01/01/2000 and 15/01/2020. Endocrine function was reviewed at the time of initial surgery and throughout follow-up. New endocrinological deficits related to the index procedure were defined as immediate failure (IF), whereas postoperative duration of endocrinological stability (ES) was analyzed using the Kaplan-Meier method. The rate of IF and ES was compared between the treatment groups. Results: Seventy-nine patients were included and had a median age of 8.3 years (range 2.1–18.0 years); 31 were males. Fifty-three patients with upfront surgical treatment, including 29 ORI and 24 gross total or partial resections had sufficient endocrinological follow-up data. Endocrine dysfunction occurring immediately after the index procedure (IF) was observed in 15 patients (62.5%) in the resection group compared to two patients (6.8%) in the ORI group, odds ratio: 0.05 (CI: 0.01–0.26, p < 0.0001). Excluding those with immediate endocrinological deficits, mean ES after ORI was 19.4 months (CI: 11.6–34.2), compared to 13.4 months (CI:10.6-NA) after surgical resection. Conclusions: Endocrine function was preserved in patients with upfront ORI (± intracystic treatment), which was confirmed as a minimally invasive procedure with an overall low morbidity profile. [ABSTRACT FROM AUTHOR]

Published
2022
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217. A brain precursor atlas reveals the acquisition of developmental-like states in adult cerebral tumours.

Author

Hamed, Akram A., Kunz, Daniel J., El-Hamamy, Ibrahim, Trinh, Quang M., Subedar, Omar D., Richards, Laura M., Foltz, Warren, Bullivant, Garrett, Ware, Matthaeus, Vladoiu, Maria C., Zhang, Jiao, Raj, Antony M., Pugh, Trevor J., Taylor, Michael D., Teichmann, Sarah A., Stein, Lincoln D., Simons, Benjamin D., and Dirks, Peter B.

Subjects
ADULT development, NEURAL development, TUMORS, ADULTS, RNA sequencing, EMBRYONIC stem cells
Abstract

Human cerebral cancers are known to contain cell types resembling the varying stages of neural development. However, the basis of this association remains unclear. Here, we map the development of mouse cerebrum across the developmental time-course, from embryonic day 12.5 to postnatal day 365, performing single-cell transcriptomics on >100,000 cells. By comparing this reference atlas to single-cell data from >100 glial tumours of the adult and paediatric human cerebrum, we find that tumour cells have an expression signature that overlaps with temporally restricted, embryonic radial glial precursors (RGPs) and their immediate sublineages. Further, we demonstrate that prenatal transformation of RGPs in a genetic mouse model gives rise to adult cerebral tumours that show an embryonic/juvenile RGP identity. Together, these findings implicate the acquisition of embryonic-like states in the genesis of adult glioma, providing insight into the origins of human glioma, and identifying specific developmental cell types for therapeutic targeting. The link between neural development and tumourigenesis in adult glioma remains unclear. Here, the authors monitor the developmental stages of Sox2 + /− stem cells from a mouse model using single-cell RNA sequencing and suggest the acquisition of embryonic-like states in the adult glioma development. [ABSTRACT FROM AUTHOR]

Published
2022
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218. The white matter is a pro-differentiative niche for glioblastoma

Author

Brooks, Lucy J., primary, Clements, Melanie P., additional, Burden, Jemima J., additional, Kocher, Daniela, additional, Richards, Luca, additional, Devesa, Sara Castro, additional, Zakka, Leila, additional, Woodberry, Megan, additional, Ellis, Michael, additional, Jaunmuktane, Zane, additional, Brandner, Sebastian, additional, Morrison, Gillian, additional, Pollard, Steven M., additional, Dirks, Peter B., additional, Marguerat, Samuel, additional, and Parrinello, Simona, additional

Published
2021
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219. Hypothermia therapy after traumatic brain injury in children

Author

Hutchison, James S., Ward, Roxanne E., Lacroix, Jacques, Hebert, Paul C., Barnes, Marcia A., Bohn, Desmond J., Dirks, Peter B., Doucette, Steve, Fergusson, Dean, Gottesman, Ronald, Joffe, Ari R., Kirpalani, Haresh M., Meyer, Phillipe G., Morris, Kevin P., Moher, David, Singh, Ram N., and Skippen, Peter W.

Subjects
Brain -- Injuries, Brain -- Care and treatment, Children -- Health aspects, Hypothermia -- Health aspects
Abstract

A study to examine the effect of hypothermia therapy on the neurological outcome and mortality among children who have undergone traumatic brain injury is conducted. Results conclude that hypothermia therapy when given within 8 hours after injury and over a period of 24 hours did not show any neurological benefits and may even increase mortality.

Published
2008

221. Integrated Molecular and Clinical Analysis of 1,000 Pediatric Low-Grade Gliomas

Author

Ryall, Scott, Zapotocky, Michal, Fukuoka, Kohei, Nobre, Liana, Guerreiro Stucklin, Ana, Bennett, Julie, Siddaway, Robert, Li, Christopher, Pajovic, Sanja, Arnoldo, Anthony, Kowalski, Paul E, Johnson, Monique, Sheth, Javal, Lassaletta, Alvaro, Tatevossian, Ruth G, Orisme, Wilda, Qaddoumi, Ibrahim, Surrey, Lea F, Li, Marilyn M, Waanders, Angela J, Gilheeney, Stephen, Rosenblum, Marc, Bale, Tejus, Tsang, Derek S, Laperriere, Normand, Kulkarni, Abhaya, Ibrahim, George M, Drake, James, Dirks, Peter, Taylor, Michael D, et al, and University of Zurich

Subjects
1307 Cell Biology, 10036 Medical Clinic, 610 Medicine & health, 2730 Oncology, 1306 Cancer Research
Published
2020

223. Roadmap for the Emerging Field of Cancer Neuroscience.

Author

Monje, Michelle, Monje, Michelle, Borniger, Jeremy C, D'Silva, Nisha J, Deneen, Benjamin, Dirks, Peter B, Fattahi, Faranak, Frenette, Paul S, Garzia, Livia, Gutmann, David H, Hanahan, Douglas, Hervey-Jumper, Shawn L, Hondermarck, Hubert, Hurov, Jonathan B, Kepecs, Adam, Knox, Sarah M, Lloyd, Alison C, Magnon, Claire, Saloman, Jami L, Segal, Rosalind A, Sloan, Erica K, Sun, Xin, Taylor, Michael D, Tracey, Kevin J, Trotman, Lloyd C, Tuveson, David A, Wang, Timothy C, White, Ruth A, Winkler, Frank, Monje, Michelle, Monje, Michelle, Borniger, Jeremy C, D'Silva, Nisha J, Deneen, Benjamin, Dirks, Peter B, Fattahi, Faranak, Frenette, Paul S, Garzia, Livia, Gutmann, David H, Hanahan, Douglas, Hervey-Jumper, Shawn L, Hondermarck, Hubert, Hurov, Jonathan B, Kepecs, Adam, Knox, Sarah M, Lloyd, Alison C, Magnon, Claire, Saloman, Jami L, Segal, Rosalind A, Sloan, Erica K, Sun, Xin, Taylor, Michael D, Tracey, Kevin J, Trotman, Lloyd C, Tuveson, David A, Wang, Timothy C, White, Ruth A, and Winkler, Frank

Abstract

Mounting evidence indicates that the nervous system plays a central role in cancer pathogenesis. In turn, cancers and cancer therapies can alter nervous system form and function. This Commentary seeks to describe the burgeoning field of "cancer neuroscience" and encourage multidisciplinary collaboration for the study of cancer-nervous system interactions.

Published
2020

226. The transcriptional landscape of Shh medulloblastoma

Author

Skowron, Patryk, primary, Farooq, Hamza, additional, Cavalli, Florence M. G., additional, Morrissy, A. Sorana, additional, Ly, Michelle, additional, Hendrikse, Liam D., additional, Wang, Evan Y., additional, Djambazian, Haig, additional, Zhu, Helen, additional, Mungall, Karen L., additional, Trinh, Quang M., additional, Zheng, Tina, additional, Dai, Shizhong, additional, Stucklin, Ana S. Guerreiro, additional, Vladoiu, Maria C., additional, Fong, Vernon, additional, Holgado, Borja L., additional, Nor, Carolina, additional, Wu, Xiaochong, additional, Abd-Rabbo, Diala, additional, Bérubé, Pierre, additional, Wang, Yu Chang, additional, Luu, Betty, additional, Suarez, Raul A., additional, Rastan, Avesta, additional, Gillmor, Aaron H., additional, Lee, John J. Y., additional, Zhang, Xiao Yun, additional, Daniels, Craig, additional, Dirks, Peter, additional, Malkin, David, additional, Bouffet, Eric, additional, Tabori, Uri, additional, Loukides, James, additional, Doz, François P., additional, Bourdeaut, Franck, additional, Delattre, Olivier O., additional, Masliah-Planchon, Julien, additional, Ayrault, Olivier, additional, Kim, Seung-Ki, additional, Meyronet, David, additional, Grajkowska, Wieslawa A., additional, Carlotti, Carlos G., additional, de Torres, Carmen, additional, Mora, Jaume, additional, Eberhart, Charles G., additional, Van Meir, Erwin G., additional, Kumabe, Toshihiro, additional, French, Pim J., additional, Kros, Johan M., additional, Jabado, Nada, additional, Lach, Boleslaw, additional, Pollack, Ian F., additional, Hamilton, Ronald L., additional, Rao, Amulya A. Nageswara, additional, Giannini, Caterina, additional, Olson, James M., additional, Bognár, László, additional, Klekner, Almos, additional, Zitterbart, Karel, additional, Phillips, Joanna J., additional, Thompson, Reid C., additional, Cooper, Michael K., additional, Rubin, Joshua B., additional, Liau, Linda M., additional, Garami, Miklós, additional, Hauser, Peter, additional, Li, Kay Ka Wai, additional, Ng, Ho-Keung, additional, Poon, Wai Sang, additional, Yancey Gillespie, G., additional, Chan, Jennifer A., additional, Jung, Shin, additional, McLendon, Roger E., additional, Thompson, Eric M., additional, Zagzag, David, additional, Vibhakar, Rajeev, additional, Ra, Young Shin, additional, Garre, Maria Luisa, additional, Schüller, Ulrich, additional, Shofuda, Tomoko, additional, Faria, Claudia C., additional, López-Aguilar, Enrique, additional, Zadeh, Gelareh, additional, Hui, Chi-Chung, additional, Ramaswamy, Vijay, additional, Bailey, Swneke D., additional, Jones, Steven J., additional, Mungall, Andrew J., additional, Moore, Richard A., additional, Calarco, John A., additional, Stein, Lincoln D., additional, Bader, Gary D., additional, Reimand, Jüri, additional, Ragoussis, Jiannis, additional, Weiss, William A., additional, Marra, Marco A., additional, Suzuki, Hiromichi, additional, and Taylor, Michael D., additional

Published
2021
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228. macroH2A2 shapes chromatin accessibility at enhancer elements in glioblastoma to modulate a targetable self-renewal epigenetic network

Author

Nikolic, Ana, primary, Bobyn, Anna, additional, Maule, Francesca, additional, Ellestad, Katrina, additional, Lun, Xueqing, additional, Johnston, Michael, additional, Gafuik, Christopher J, additional, Zemp, Franz J, additional, Paik, Seungil, additional, Ninkovic, Nicoletta, additional, Marhon, Sajid A, additional, Mehdipour, Parinaz, additional, Shen, Yaoqing, additional, Berger, N. Daniel, additional, Brownsey, Duncan K, additional, Dirks, Peter B, additional, Derksen, Darren J, additional, Jones, Steven JM, additional, de Carvalho, Daniel, additional, Senger, Donna L, additional, Chan, Jennifer A, additional, Mahoney, Douglas J, additional, and Gallo, Marco, additional

Published
2021
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229. Mutation and Microsatellite Burden Predict Response to PD-1 Inhibition in Children with Germline DNA Replication Repair Deficiency

Author

Tabori, Uri, primary, Morgenstern, Daniel, additional, Sudhaman, Sumedha, additional, Das, Anirban, additional, Coblentz, Ailish, additional, Chung, Jiil, additional, Stone, Simone, additional, Alsafwani, Noor, additional, Cabric, Vanja, additional, Nobre, Liana, additional, Bianchi, Vanessa, additional, Edwards, Melissa, additional, Sambira, Lauren, additional, Constantini, Shlomi, additional, Dvir, Rina, additional, Yalon, Michal, additional, Campino, Gadi, additional, Caspi, Shani, additional, Larouche, Valerie, additional, Reddy, Alyssa, additional, Osborn, Michael, additional, Mason, Gary, additional, Lindhorst, Scott, additional, Bronsema, Annika, additional, Magimairajan, Vanan, additional, Opocher, Enrico, additional, De Mola, Rebecca, additional, Sabel, Magnus, additional, Frojd, Charlotta, additional, Sumerauer, David, additional, Samuel, David, additional, Cole, Kristina, additional, Chiaravalli, Stefano, additional, Massimino, Maura, additional, Tomboc, Patrick, additional, Ziegler, David, additional, George, Ben, additional, Damme, An Van, additional, Hijaya, Nobuko, additional, Gass, David, additional, McGee, Rose, additional, Mordechai, Oz, additional, Bowers, Daniel, additional, Laetsch, Ted, additional, Lossos, Alexander, additional, Blumenthal, Deborah, additional, Sarosiek, Tomasz, additional, Yen, Lee, additional, Knipstein, Jeffrey, additional, Bendel, Anne, additional, Hoffman, Lindsey, additional, Luna-Fineman, Sandra, additional, Zimmermann, Stefanie, additional, Scheers, Isabelle, additional, Nichols, Kim, additional, Zapotocky, Michal, additional, Hansford, Jordan, additional, Maris, John, additional, Dirks, Peter, additional, Taylor, Michael, additional, Kulkarni, Abhaya, additional, Shroff, Manohar, additional, Tsang, Derek, additional, Malkin, David, additional, Villani, Anita, additional, Aronson, Melyssa, additional, Durno, Carol, additional, Shlien, Adam, additional, Getz, Gad, additional, Maruvka, Yosef, additional, Ohashi, Pamela, additional, Hawkins, Cynthia, additional, Pugh, Trevor, additional, and Bouffet, Eric, additional

Published
2021
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230. PRMT5 inhibition disrupts splicing and stemness in glioblastoma

Author

Sachamitr, Patty, primary, Ho, Jolene C., additional, Ciamponi, Felipe E., additional, Ba-Alawi, Wail, additional, Coutinho, Fiona J., additional, Guilhamon, Paul, additional, Kushida, Michelle M., additional, Cavalli, Florence M. G., additional, Lee, Lilian, additional, Rastegar, Naghmeh, additional, Vu, Victoria, additional, Sánchez-Osuna, María, additional, Coulombe-Huntington, Jasmin, additional, Kanshin, Evgeny, additional, Whetstone, Heather, additional, Durand, Mathieu, additional, Thibault, Philippe, additional, Hart, Kirsten, additional, Mangos, Maria, additional, Veyhl, Joseph, additional, Chen, Wenjun, additional, Tran, Nhat, additional, Duong, Bang-Chi, additional, Aman, Ahmed M., additional, Che, Xinghui, additional, Lan, Xiaoyang, additional, Whitley, Owen, additional, Zaslaver, Olga, additional, Barsyte-Lovejoy, Dalia, additional, Richards, Laura M., additional, Restall, Ian, additional, Caudy, Amy, additional, Röst, Hannes L., additional, Bonday, Zahid Quyoom, additional, Bernstein, Mark, additional, Das, Sunit, additional, Cusimano, Michael D., additional, Spears, Julian, additional, Bader, Gary D., additional, Pugh, Trevor J., additional, Tyers, Mike, additional, Lupien, Mathieu, additional, Haibe-Kains, Benjamin, additional, Artee Luchman, H., additional, Weiss, Samuel, additional, Massirer, Katlin B., additional, Prinos, Panagiotis, additional, Arrowsmith, Cheryl H., additional, and Dirks, Peter B., additional

Published
2021
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231. Single-cell chromatin accessibility profiling of glioblastoma identifies an invasive cancer stem cell population associated with lower survival

Author

Guilhamon, Paul, primary, Chesnelong, Charles, additional, Kushida, Michelle M, additional, Nikolic, Ana, additional, Singhal, Divya, additional, MacLeod, Graham, additional, Madani Tonekaboni, Seyed Ali, additional, Cavalli, Florence MG, additional, Arlidge, Christopher, additional, Rajakulendran, Nishani, additional, Rastegar, Naghmeh, additional, Hao, Xiaoguang, additional, Hassam, Rozina, additional, Smith, Laura J, additional, Whetstone, Heather, additional, Coutinho, Fiona J, additional, Nadorp, Bettina, additional, Ellestad, Katrina I, additional, Luchman, H Artee, additional, Chan, Jennifer Ai-wen, additional, Shoichet, Molly S, additional, Taylor, Michael D, additional, Haibe-Kains, Benjamin, additional, Weiss, Samuel, additional, Angers, Stephane, additional, Gallo, Marco, additional, Dirks, Peter B, additional, and Lupien, Mathieu, additional

Published
2021
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232. Author response: Single-cell chromatin accessibility profiling of glioblastoma identifies an invasive cancer stem cell population associated with lower survival

Author

Guilhamon, Paul, primary, Chesnelong, Charles, additional, Kushida, Michelle M, additional, Nikolic, Ana, additional, Singhal, Divya, additional, MacLeod, Graham, additional, Madani Tonekaboni, Seyed Ali, additional, Cavalli, Florence MG, additional, Arlidge, Christopher, additional, Rajakulendran, Nishani, additional, Rastegar, Naghmeh, additional, Hao, Xiaoguang, additional, Hassam, Rozina, additional, Smith, Laura J, additional, Whetstone, Heather, additional, Coutinho, Fiona J, additional, Nadorp, Bettina, additional, Ellestad, Katrina I, additional, Luchman, H Artee, additional, Chan, Jennifer Ai-wen, additional, Shoichet, Molly S, additional, Taylor, Michael D, additional, Haibe-Kains, Benjamin, additional, Weiss, Samuel, additional, Angers, Stephane, additional, Gallo, Marco, additional, Dirks, Peter B, additional, and Lupien, Mathieu, additional

Published
2021
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233. Gradient of Developmental and Injury Response transcriptional states defines functional vulnerabilities underpinning glioblastoma heterogeneity

Author

Richards, Laura M., primary, Whitley, Owen K. N., additional, MacLeod, Graham, additional, Cavalli, Florence M. G., additional, Coutinho, Fiona J., additional, Jaramillo, Julia E., additional, Svergun, Nataliia, additional, Riverin, Mazdak, additional, Croucher, Danielle C., additional, Kushida, Michelle, additional, Yu, Kenny, additional, Guilhamon, Paul, additional, Rastegar, Naghmeh, additional, Ahmadi, Moloud, additional, Bhatti, Jasmine K., additional, Bozek, Danielle A., additional, Li, Naijin, additional, Lee, Lilian, additional, Che, Clare, additional, Luis, Erika, additional, Park, Nicole I., additional, Xu, Zhiyu, additional, Ketela, Troy, additional, Moore, Richard A., additional, Marra, Marco A., additional, Spears, Julian, additional, Cusimano, Michael D., additional, Das, Sunit, additional, Bernstein, Mark, additional, Haibe-Kains, Benjamin, additional, Lupien, Mathieu, additional, Luchman, H. Artee, additional, Weiss, Samuel, additional, Angers, Stephane, additional, Dirks, Peter B., additional, Bader, Gary D., additional, and Pugh, Trevor J., additional

Published
2021
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234. Reevaluating surgery and re-irradiation for locally recurrent pediatric ependymoma—a multi-institutional study

Author

Mak, David Y, primary, Laperriere, Normand, additional, Ramaswamy, Vijay, additional, Bouffet, Eric, additional, Murray, Jeffrey C, additional, McNall-Knapp, Rene Y, additional, Bielamowicz, Kevin, additional, Paulino, Arnold C, additional, Zaky, Wafik, additional, McGovern, Susan L, additional, Okcu, M Fatih, additional, Tabori, Uri, additional, Atwi, Doaa, additional, Dirks, Peter B, additional, Taylor, Michael D, additional, Tsang, Derek S, additional, and Bavle, Abhishek, additional

Published
2021
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238. Identification of human brain tumour initiating cells

Author

Singh, Sheila K., Hawkins, Cynthia, Clarke, Ian D., Squire, Jeremy A., Bayani, Jane, Hide, Takuichiro, Henkelman, R. Mark, Cusimano, Michael D., and Dirks, Peter B.

Subjects
Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Sheila K. Singh [1, 2, 3]; Cynthia Hawkins [1, 4]; Ian D. Clarke [1, 2]; Jeremy A. Squire [6]; Jane Bayani [6]; Takuichiro Hide [1, 2]; R. Mark Henkelman [...]

Published
2004
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241. Contributors

Author

Aarabi, Bizhan, primary, Abbott, Rick, additional, Abdulrauf, Saleem I., additional, Acosta, Frank L., additional, Adler, John R., additional, Agazaryan, Nzhde, additional, Aghi, Manish, additional, Ahn, Edward S., additional, Alaraj, Ali, additional, Albert, Gregory W., additional, Albright, Leland, additional, Albuquerque, Felipe C., additional, Alden, Tord D., additional, Alexander, Michael J., additional, Alexandrov, Andrei V., additional, Al-Mefty, Ossama, additional, Alterman, Ron L., additional, Álvarez, Lázaro, additional, Amankulor, Nduka M., additional, Amenta, Peter S., additional, Ames, Christopher P., additional, Amin-Hanjani, Sepideh, additional, Ammirati, Mario, additional, Anderson, Carryn, additional, Anderson, Richard C.E., additional, Anderson, William S., additional, Angevine, Peter D., additional, Arif, Hiba, additional, Arle, Jeffrey E., additional, Armonda, Rocco, additional, Arnold, Paul M., additional, Asadi-Moghaddam, Kaveh, additional, Asghar, Ferhan A., additional, Ashley, William W., additional, Aydin, Sabri, additional, Aygun, Nafi, additional, Baehring, Joachim M., additional, Bagley, Jacob H., additional, Bahgat, Diaa, additional, Bailes, Julian E., additional, Ball, Jonathon R., additional, Baltuch, Gordon H., additional, Bambakidis, Nicholas C., additional, Baraban, Scott C., additional, Barani, Igor J., additional, Barbaro, Nicholas M., additional, Barker, Frederick G., additional, Barnett, Gene H., additional, Barnwell, Stanley L., additional, Barone, Constance M., additional, Barrow, Daniel L., additional, Bartolomei, Fabrice, additional, Bartolomei, Juan, additional, Batchelor, Tracy T., additional, Batjer, H. Hunt, additional, Bauer, Andrew M., additional, Bauman, Joel A., additional, Baumann, Thomas K., additional, Baumgartner, James E., additional, Bayouth, John, additional, Beaumont, Andrew, additional, Bederson, Joshua B., additional, Beisse, Rudolf, additional, Bell, Randy S., additional, Belzberg, Allan, additional, Benabid, Alim Louis, additional, Benarroch, Eduardo E., additional, Benazzouz, Abdelhamid, additional, Bendok, Bernard R., additional, Benzel, Edward C., additional, Berenstein, Alejandro, additional, Berger, Mitchel S., additional, Bergsneider, Marvin, additional, Bertalanffy, Helmut, additional, Bhalla, Tarun, additional, Bidros, Dani S., additional, Biller, José, additional, Bilsky, Mark H., additional, Binder, Devin K., additional, Bingaman, William, additional, Birch, Rolfe, additional, Bishop, Allen T., additional, Black, Peter M., additional, Blount, Jeffrey P., additional, Blumbergs, Peter C., additional, Bohman, Leif-Erik, additional, Boomsaad, Zackary E., additional, Boop, Frederick A., additional, Bou-Haidar, Pascal, additional, Boué, Daniel R., additional, Bourgeois, Blaise F.D., additional, Bowman, Robin M., additional, Bozinov, Oliver, additional, Bramlett, Helen M., additional, Brem, Henry, additional, Brem, Steven, additional, Britz, Gavin W., additional, Brockmeyer, Douglas L., additional, Brooks, David J., additional, Browd, Samuel R., additional, Brown, Paul D., additional, Brown, Robert D., additional, Bruce, Jeffrey N., additional, Brunstrom-Hernandez, Janice E., additional, Buatti, John, additional, Bullock, M. Ross, additional, Burchiel, Kim J., additional, Burger, Peter C., additional, Bussière, Marc R., additional, Bydon, Mohamad, additional, Byrne, Richard W., additional, Calcagnotto, Maria Elisa, additional, Campbell, Victoria A., additional, Campbell, William, additional, Cannon, George M., additional, Caragine, Louis P., additional, Carson, Benjamin S., additional, Cascino, Gregory D., additional, Cascio, Ethan, additional, Castinetti, Frédéric, additional, Cawley, C. Michael, additional, Cetas, Justin S., additional, Chabardès, Stéphan, additional, Chang, Edward F., additional, Chang, Eric C., additional, Chang, Eric L., additional, Chang, Steven D., additional, Chang, Steven W., additional, Chang, Susan M., additional, Chao, Kevin, additional, Chapman, Paul H., additional, Charbel, Fady T., additional, Chauvel, Patrick, additional, Chen, Grace, additional, Cheng, Boyle C., additional, Cheng, Joseph S., additional, Chern, Joshua J., additional, Chiocca, E. Antonio, additional, Choutka, Ondrej, additional, Chowdhry, Shakeel A., additional, Christian, Cindy W., additional, Chuang, Kathy, additional, Claassen, Jan, additional, Clatterbuck, Richard E., additional, Claus, Elizabeth B., additional, Cleary, Daniel R., additional, Coffey, Robert J., additional, Cohen, Alan R., additional, Cole, Andrew J., additional, Connolly, E. Sander, additional, Connolly, Patrick J., additional, Copay, Anne G., additional, Coppens, Jeroen R., additional, Corbett, James J., additional, Corcos, Daniel M., additional, Coric, Domagoj, additional, Cosgrove, Garth Rees, additional, Couldwell, William T., additional, Craig, Stirling, additional, Crawford, Neil R., additional, Crino, Peter B., additional, Crowley, R. Webster, additional, Curt, Bradford A., additional, Czosnyka, Marek, additional, Czosnyka, Zofia, additional, Dadashev, Vladimir Y., additional, Dailey, Andrew T., additional, Danan, Deepa, additional, Danish, Shabbar F., additional, Dashti, Shervin R., additional, David, Carlos A., additional, David, David J., additional, Day, Arthur L., additional, De Salles, Antonio A.F., additional, Dehdashti, Amir R., additional, Del Brutto, Oscar H., additional, Delashaw, Johnny B., additional, Delman, Bradley, additional, DeLong, Mahlon R., additional, DeMonte, Franco, additional, Dhall, Sanjay S., additional, Dias, Mark S., additional, Dickman, Curtis A., additional, Dietrich, W. Dalton, additional, DiLuna, Michael L., additional, Di Meco, Francesco, additional, Dirks, Peter, additional, Dixon, C. Edward, additional, Donoghue, Jacob A., additional, Dorward, Ian G., additional, Doshi, Amish H., additional, Drake, James, additional, Drzymalski, Dan, additional, Du, Rose, additional, Ducruet, Andrew, additional, Duhaime, Ann-Christine, additional, Dumont, Aaron S., additional, Duntsch, Christopher D., additional, Dusick, Joshua R., additional, Dyve, Suzan, additional, Eberwine, James, additional, Eboli, Paula, additional, Ecker, Robert D., additional, Edwards, Richard J., additional, Eichler, Marc E., additional, Engel, Doortje C., additional, Epstein, Nancy E., additional, Ewend, Matthew G., additional, Farhat, Hamad, additional, Farrell, Christopher J., additional, Fehlings, Michael G., additional, Feiz-Erfan, Iman, additional, Feldstein, Neil A., additional, Fessler, Richard G., additional, Figueroa, Juan J., additional, Filler, Aaron G., additional, Findlay, J. 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Dade, additional, Luther, Neal, additional, Lylyk, Pedro, additional, Maas, Andrew I.R., additional, Macdonald, R. Loch, additional, Machado, Andre, additional, Macias, Raul, additional, Maciunas, Robert J., additional, Maddux, Brian N., additional, Magistretti, Pierre, additional, Malessy, Martijn J.A., additional, Malhotra, Neil R., additional, Malone, Donald A., additional, Mamelak, Adam N., additional, Mandigo, Christopher E., additional, Mangano, Francesco T., additional, Maniker, Allen H., additional, Manley, Geoffrey T., additional, Marchac, Daniel, additional, Marmarou, Anthony, additional, Maroon, Joseph C., additional, Marshall, Lawrence F., additional, Martin, Neil A., additional, Martin, Timothy J., additional, Mason, Alexander M., additional, Mathews, Marlon S., additional, Mayberg, Helen S., additional, McAllister, James P., additional, McComb, J. Gordon, additional, McCormick, Paul C., additional, McCutcheon, Ian E., additional, McDermott, Michael W., additional, McDougall, Cameron G., additional, McGehee, Matthew, additional, McIntyre, Cameron C., additional, McKhann, Guy M., additional, McKisic, M. Sean, additional, Meaney, David F., additional, Mehta, Minesh P., additional, Mehta, Vivek, additional, Melega, William P., additional, Menezes, Arnold H., additional, Mertens, Patrick, additional, Meyer, Fredric B., additional, Meyer, Scott A., additional, Meyers, Philip M., additional, Michaelides, Costas, additional, Michaud, Karine, additional, Midha, Rajiv, additional, Miele, Vincent J., additional, Miller, Jonathan, additional, Miller, Matthew L., additional, Miller, Neil R., additional, Mitrofanis, John, additional, Miyashiro, Kevin Y., additional, Mocco, J., additional, Modic, Michael T., additional, Moftakhar, Parham, additional, Mohan, Avinash, additional, Monteith, Stephen J., additional, Morcos, Jacques J., additional, Morgan, Michael, additional, Morris, David E., additional, Moss, S. David, additional, Muizelaar, J. 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Mark, additional, Rigamonti, Daniele, additional, Riggins, Gregory J., additional, Riva-Cambrin, Jay, additional, Rizzo, Paolo, additional, Roberts, David W., additional, Robertson, Claudia, additional, Robinson, Lawrence, additional, Robinson, Shenandoah, additional, Roche, Pierre-Hugues, additional, Rockoff, Mark A., additional, Rodts, Gerald E., additional, Romanelli, Pantaleo, additional, Rosenblum, Mark L., additional, Rosenow, Joshua M., additional, Rosner, Michael K., additional, Rovner, Eric S., additional, Runge-Samuelson, Christina L., additional, Russell, Stephen M., additional, Rutka, James T., additional, Sagher, Oren, additional, St. Clair, Eric G., additional, Samii, Madjid, additional, Sampath, Prakash, additional, Samudrala, Srinath, additional, Sanai, Nader, additional, Sanford, Robert A., additional, Santiago, Paul, additional, Santiago-Sim, Teresa, additional, Sarnat, Harvey B., additional, Sawaya, Raymond, additional, Scheld, W. 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Gregory, additional, Tiel,, Robert, additional, Tihan, Tarik, additional, Tilton, Ann, additional, Timmons, Shelly D., additional, Toledo, Maria, additional, Tomita, Tadanori, additional, Tomycz, Nestor D., additional, Torres, Napoleon, additional, Toussaint, Charles P., additional, Trapp, Bruce D., additional, Traynelis, Vincent C., additional, Tubbs, R. Shane, additional, Tumialán, Luis M., additional, Tunkel, Allan R., additional, Umemura, Atsushi, additional, Vaccaro, Alexander R., additional, van Besien, Koen, additional, Vitek, Jerrold L., additional, Vives, Kenneth P., additional, Vogel, Timothy W., additional, Vogelbaum, Michael A., additional, Vollmer, Dennis G., additional, Von Allmen, Gretchen K., additional, von Eckardstein, Kajetan L., additional, Wackym, P. Ashley, additional, Wainwright, Mark, additional, Waldau, Ben, additional, Walker, Marion L., additional, Wallace, M. Christopher, additional, Walsh, Brian, additional, Wang, Huan, additional, Wang, Michael Y., additional, Wang, Vincent Y., additional, Warnick, Ronald E., additional, Webb, Sharon, additional, Weigel, Ralf, additional, Weil, Robert J., additional, Weingart, Jon D., additional, Weir, Bryce, additional, Weiss, Martin, additional, Weiss, Nirit, additional, Welch, William C., additional, Wellons, John C., additional, Wen, Hung Tzu, additional, Wess, Christian, additional, West, G. Alexander, additional, Wetjen, Nicholas M., additional, Whitmore, Robert G., additional, Whitworth, Louis A., additional, Wichmann, Thomas, additional, Wiemels, Joseph L., additional, Wijdicks, Eelco F.M., additional, Wilberger, Adam C., additional, Wilberger, Jack, additional, Wildrick, David M., additional, Wilson, Jason, additional, Winfree, Christopher J., additional, Winn, H. Richard, additional, Wolfla, Christopher, additional, Wong, Eric T., additional, Wormald, Peter J., additional, Wrensch, Margaret, additional, Wright, Neill M., additional, Wright, Zachary, additional, Yam, David, additional, Yamada, Shinya, additional, Yamada, Yoshiya, additional, Yang, Isaac, additional, Yang, Victor X.D., additional, Yao, Tom, additional, Yen, Chun-Po, additional, Yeoh, H. Kwang, additional, Yonekawa, Yasuhiro, additional, Yoo, Alice, additional, Yousem, David M., additional, Yuen, Eric C., additional, Zabramski, Joseph M., additional, Zacest, Andrew C., additional, Zacko, J. Christopher, additional, Zada, Gabriel, additional, Zafonte, Ross, additional, Zager, Eric L., additional, Zaidi, Hasan A., additional, Zarzour, Hekmat, additional, Zerris, Vasilios A., additional, Zivin, Justin A., additional, Zovickian, John G., additional, Zubkov, Alexander Y., additional, and Zwienenberg-Lee, Marike, additional

Published
2011
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246. Single-cell chromatin profiling of the primitive gut tube reveals regulatory dynamics underlying lineage fate decisions.

Author

Smith, Ryan J., Zhang, Hongpan, Hu, Shengen Shawn, Yung, Theodora, Francis, Roshane, Lee, Lilian, Onaitis, Mark W., Dirks, Peter B., Zang, Chongzhi, and Kim, Tae-Hee

Subjects
CHROMATIN, TRANSCRIPTION factors, GASTROINTESTINAL system, MORPHOGENESIS, ADULT development, EPIGENOMICS
Abstract

Development of the gastrointestinal system occurs after gut tube closure, guided by spatial and temporal control of gene expression. However, it remains unclear what forces regulate these spatiotemporal gene expression patterns. Here we perform single-cell chromatin profiling of the primitive gut tube to reveal organ-specific chromatin patterns that reflect the anatomical patterns of distinct organs. We generate a comprehensive map of epigenomic changes throughout gut development, demonstrating that dynamic chromatin accessibility patterns associate with lineage-specific transcription factor binding events to regulate organ-specific gene expression. Additionally, we show that loss of Sox2 and Cdx2, foregut and hindgut lineage-specific transcription factors, respectively, leads to fate shifts in epigenomic patterns, linking transcription factor binding, chromatin accessibility, and lineage fate decisions in gut development. Notably, abnormal expression of Sox2 in the pancreas and intestine impairs lineage fate decisions in both development and adult homeostasis. Together, our findings define the chromatin and transcriptional mechanisms of organ identity and lineage plasticity in development and adult homeostasis. The primitive gut tube gives rise to all major internal organs, while underlying regulatory mechanisms are unclear. Here, the authors analyze its chromatin landscape at the single-cell level and define the epigenetic regulation of lineage fate decisions and plasticity in organ development and homeostasis. [ABSTRACT FROM AUTHOR]

Published
2022
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247. Subgroup-specific structural variation across 1,000 medulloblastoma genomes

Author

Northcott, Paul A., Shih, David J. H., Peacock, John, Garzia, Livia, Morrissy, Sorana A., Zichner, Thomas, Stütz, Adrian M., Korshunov, Andrey, Reimand, Jüri, Schumacher, Steven E., Beroukhim, Rameen, Ellison, David W., Marshall, Christian R., Lionel, Anath C., Mack, Stephen, Dubuc, Adrian, Yao, Yuan, Ramaswamy, Vijay, Luu, Betty, Rolider, Adi, Cavalli, Florence M. G., Wang, Xin, Remke, Marc, Wu, Xiaochong, Chiu, Readman Y. B., Chu, Andy, Chuah, Eric, Corbett, Richard D., Hoad, Gemma R., Jackman, Shaun D., Li, Yisu, Lo, Allan, Mungall, Karen L., Nip, Ka Ming, Qian, Jenny Q., Raymond, Anthony G. J., Thiessen, Nina, Varhol, Richard J., Birol, Inanc, Moore, Richard A., Mungall, Andrew J., Holt, Robert, Kawauchi, Daisuke, Roussel, Martine F., Kool, Marcel, Jones, David T. W., Witt, Hendrick, Fernandez-L, Africa, Kenney, Anna M., Wechsler-Reya, Robert J., Dirks, Peter, Aviv, Tzvi, Grajkowska, Wieslawa A., Perek-Polnik, Marta, Haberler, Christine C., Delattre, Olivier, Reynaud, Stéphanie S., Doz, François F., Pernet-Fattet, Sarah S., Cho, Byung-Kyu, Kim, Seung-Ki, Wang, Kyu-Chang, Scheurlen, Wolfram, Eberhart, Charles G., Fèvre-Montange, Michelle, Jouvet, Anne, Pollack, Ian F., Fan, Xing, Muraszko, Karin M., Gillespie, Yancey G., Di Rocco, Concezio, Massimi, Luca, Michiels, Erna M. C., Kloosterhof, Nanne K., French, Pim J., Kros, Johan M., Olson, James M., Ellenbogen, Richard G., Zitterbart, Karel, Kren, Leos, Thompson, Reid C., Cooper, Michael K., Lach, Boleslaw, McLendon, Roger E., Bigner, Darell D., Fontebasso, Adam, Albrecht, Steffen, Jabado, Nada, Lindsey, Janet C., Bailey, Simon, Gupta, Nalin, Weiss, William A., Bognár, László, Klekner, Almos, Van Meter, Timothy E., Kumabe, Toshihiro, Tominaga, Teiji, Elbabaa, Samer K., Leonard, Jeffrey R., Rubin, Joshua B., Liau, Linda M., Van Meir, Erwin G., Fouladi, Maryam, Nakamura, Hideo, Cinalli, Giuseppe, Garami, Miklós, Hauser, Peter, Saad, Ali G., Iolascon, Achille, Jung, Shin, Carlotti, Carlos G., Vibhakar, Rajeev, Ra, Young Shin, Robinson, Shenandoah, Zollo, Massimo, Faria, Claudia C., Chan, Jennifer A., Levy, Michael L., Sorensen, Poul H. B., Meyerson, Matthew, Pomeroy, Scott L., Cho, Yoon-Jae, Bader, Gary D., Tabori, Uri, Hawkins, Cynthia E., Bouffet, Eric, Scherer, Stephen W., Rutka, James T., Malkin, David, Clifford, Steven C., Jones, Steven J. M., Korbel, Jan O., Pfister, Stefan M., Marra, Marco A., and Taylor, Michael D.

Published
2012
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