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1,425 results on '"Dijk, F"'

203. Novel genes and insights in complete asthma remission: A genome-wide association study on clinical and complete asthma remission

Author

Vonk, J. M., primary, Nieuwenhuis, M. A. E., additional, Dijk, F. N., additional, Boudier, A., additional, Siroux, V., additional, Bouzigon, E., additional, Probst-Hensch, N., additional, Imboden, M., additional, Keidel, D., additional, Sin, D., additional, Bossé, Y., additional, Hao, K., additional, van den Berge, M., additional, Faiz, A., additional, Koppelman, G. H., additional, and Postma, D. S., additional

Published
2018
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210. Genetic regulation of IL1RL1 methylation and IL1RL1-a protein levels in asthma

Author

Dijk, F. Nicole, primary, Xu, Chengjian, additional, Melén, Erik, additional, Carsin, Anne-Elie, additional, Kumar, Asish, additional, Nolte, Ilja M., additional, Gruzieva, Olena, additional, Pershagen, Goran, additional, Grotenboer, Neomi S., additional, Savenije, Olga E.M., additional, Antó, Josep Maria, additional, Lavi, Iris, additional, Dobaño, Carlota, additional, Bousquet, Jean, additional, van der Vlies, Pieter, additional, van der Valk, Ralf J.P., additional, de Jongste, Johan C., additional, Nawijn, Martijn C., additional, Guerra, Stefano, additional, Postma, Dirkje S., additional, and Koppelman, Gerard H., additional

Published
2018
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214. Novel algorithms for improved sensitivity in non-invasive prenatal testing

Author

Johansson, Lennart F., De Boer, E. N., De Weerd, H. A., van Dijk, F., Elferink, M. G., Schuring-Blom, G. H., Suijkerbuijk, Ron F, Sinke, Richard J., Te Meerman, G. J., Sijmons, Rolf H., Swertz, Morris A., Sikkema-Raddatz, B., Johansson, Lennart F., De Boer, E. N., De Weerd, H. A., van Dijk, F., Elferink, M. G., Schuring-Blom, G. H., Suijkerbuijk, Ron F, Sinke, Richard J., Te Meerman, G. J., Sijmons, Rolf H., Swertz, Morris A., and Sikkema-Raddatz, B.

Published
2017

216. Bridging Rotterdam: A bridge is more

Author

van Dijk, F. (author) and van Dijk, F. (author)

Abstract

Architecture and The Built Environment, Urbanism, Design of the Urban Fabric

Published
2017

217. Novel algorithms for improved sensitivity in non-invasive prenatal testing

Author

UMC Utrecht, Genetica, Genetica Medische Informatica, Child Health, Genetica Sectie Genoomdiagnostiek, Cancer, Johansson, Lennart F., De Boer, E. N., De Weerd, H. A., van Dijk, F., Elferink, M. G., Schuring-Blom, G. H., Suijkerbuijk, Ron F, Sinke, Richard J., Te Meerman, G. J., Sijmons, Rolf H., Swertz, Morris A., Sikkema-Raddatz, B., UMC Utrecht, Genetica, Genetica Medische Informatica, Child Health, Genetica Sectie Genoomdiagnostiek, Cancer, Johansson, Lennart F., De Boer, E. N., De Weerd, H. A., van Dijk, F., Elferink, M. G., Schuring-Blom, G. H., Suijkerbuijk, Ron F, Sinke, Richard J., Te Meerman, G. J., Sijmons, Rolf H., Swertz, Morris A., and Sikkema-Raddatz, B.

Published
2017

218. Rationale and design of the multiethnic Pharmacogenomics in Childhood Asthma consortium

Author

Farzan, Niloufar, Vijverberg, Susanne J, Andiappan, Anand K, Arianto, Lambang, Berce, Vojko, Blanca-López, Natalia, Bisgaard, Hans, Bønnelykke, Klaus, Burchard, Esteban G, Campo, Paloma, Canino, Glorisa, Carleton, Bruce, Celedón, Juan C, Chew, Fook Tim, Chiang, Wen Chin, Cloutier, Michelle M, Daley, Denis, Den Dekker, Herman T, Dijk, F Nicole, Duijts, Liesbeth, Flores, Carlos, Forno, Erick, Hawcutt, Daniel B, Hernandez-Pacheco, Natalia, de Jongste, Johan C, Kabesch, Michael, Koppelman, Gerard H, Manolopoulos, Vangelis G, Melén, Erik, Mukhopadhyay, Somnath, Nilsson, Sara, Palmer, Colin N, Pino-Yanes, Maria, Pirmohamed, Munir, Potočnik, Uros, Raaijmakers, Jan A, Repnik, Katja, Schieck, Maximilian, Sio, Yang Yie, Smyth, Rosalind L, Szalai, Csaba, Tantisira, Kelan G, Turner, Steve, van der Schee, Marc P, Verhamme, Katia M, Maitland-van der Zee, Anke H, Farzan, Niloufar, Vijverberg, Susanne J, Andiappan, Anand K, Arianto, Lambang, Berce, Vojko, Blanca-López, Natalia, Bisgaard, Hans, Bønnelykke, Klaus, Burchard, Esteban G, Campo, Paloma, Canino, Glorisa, Carleton, Bruce, Celedón, Juan C, Chew, Fook Tim, Chiang, Wen Chin, Cloutier, Michelle M, Daley, Denis, Den Dekker, Herman T, Dijk, F Nicole, Duijts, Liesbeth, Flores, Carlos, Forno, Erick, Hawcutt, Daniel B, Hernandez-Pacheco, Natalia, de Jongste, Johan C, Kabesch, Michael, Koppelman, Gerard H, Manolopoulos, Vangelis G, Melén, Erik, Mukhopadhyay, Somnath, Nilsson, Sara, Palmer, Colin N, Pino-Yanes, Maria, Pirmohamed, Munir, Potočnik, Uros, Raaijmakers, Jan A, Repnik, Katja, Schieck, Maximilian, Sio, Yang Yie, Smyth, Rosalind L, Szalai, Csaba, Tantisira, Kelan G, Turner, Steve, van der Schee, Marc P, Verhamme, Katia M, and Maitland-van der Zee, Anke H

Abstract

AIM: International collaboration is needed to enable large-scale pharmacogenomics studies in childhood asthma. Here, we describe the design of the Pharmacogenomics in Childhood Asthma (PiCA) consortium.MATERIALS & METHODS: Investigators of each study participating in PiCA provided data on the study characteristics by answering an online questionnaire.RESULTS: A total of 21 studies, including 14,227 children/young persons (58% male), from 12 different countries are currently enrolled in the PiCA consortium. Fifty six percent of the patients are Caucasians. In total, 7619 were inhaled corticosteroid users. Among patients from 13 studies with available data on asthma exacerbations, a third reported exacerbations despite inhaled corticosteroid use. In the future pharmacogenomics studies within the consortium, the pharmacogenomics analyses will be performed separately in each center and the results will be meta-analyzed.CONCLUSION: PiCA is a valuable platform to perform pharmacogenetics studies within a multiethnic pediatric asthma population.

Published
2017

220. A high-quality reference panel reveals the complexity and distribution of structural genome changes in a human population

Author

Jayne Y. Hehir-Kwa, van Ommen Gb, Dijkstra Lj, Guryev, Wigard P. Kloosterman, Andre G. Uitterlinden, Eric-Wubbo Lameijer, Patrick Deelen, de Bakker P, Kai Ye, Thung Dt, René Wardenaar, Alexander Schoenhuth, van Dijk F, Bradley P. Coe, Laurent C. Francioli, Jasmijn A. Baaijens, Ivo Renkens, de Ligt J, Eline Slagboom P, Evan E. Eichler, Fereydoun Hormozdiari, Cisca Wijmenga, Dorret I. Boomsma, Abdel Abdellaoui, Koval, Morris A. Swertz, and Tobias Marschall

Subjects
Genetics, 0303 health sciences, Linkage disequilibrium, education.field_of_study, Population, Computational biology, Biology, Genome, Structural variation, 03 medical and health sciences, 0302 clinical medicine, Human genome, Mobile genetic elements, education, 030217 neurology & neurosurgery, Imputation (genetics), 030304 developmental biology, Genetic association
Abstract

Structural variation (SV) represents a major source of differences between individual human genomes and has been linked to disease phenotypes. However, current studies on SVs have failed to provide a global view of the full spectrum of SVs and to integrate them into reference panels of genetic variation. Here, we analyzed 769 individuals from 250 Dutch families, whole genome sequenced at an average coverage of 14.5x, and provide a haplotype-resolved map of 1.9 million genome variants across 9 different variant classes, including novel forms of complex indels and retrotransposition-mediated insertions of mobile elements and processed RNAs. A large proportion of the structural variants (36%) were discovered in the size range of 21 to 100bp, a size range which remains under reported in many studies. Furthermore, we detected 4 megabases of novel sequence, extending the human pangenome with 11 new active transcripts. Finally, we show 191 known, trait-associated SNPs to be in strong linkage disequilibrium with a structural variant and demonstrate that our panel facilitates accurate imputation of SVs into unrelated individuals, which is essential for future genome-wide association studies.

Published
2016
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221. Functional polymorphism in the CDKN2A-CDKN2B gene regions affect pancreatic cancer risk

Author

Campa, D, Pastore, M, Gentiluomo, M, Pezzilli, R, Boggi, U, Capurso, G, Talar Wojnarowska, R, Kupcinskas, J, Hackert, T, Vodika, P, Brenner, H, Khaw, Tk, Landi, S, Tavano, F, Costello, E, Mambrini, A, Scarpa, A, Soucek, P, Gazouli, M, Milanetto, ANNA CATERINA, Rizzato, C, Dijk, F, Vashist, Yk, Cavestro, Gm, and Canzian, F.

Published
2016

222. Financiering van de Rechtspraak in rechtsstatelijk kader: Generieke kortingen op het rechtspreken zijn in strijd met de wet

Author

van Dijk, F., Sterk, Kees, and Sub Burgerlijk Recht

Abstract

De Wet op de Rechterlijke Organisatie en het daarop gebaseerde Besluit financiering rechtspraak1 normeren de financiering van de Rechtspraak. Daarin is om rechtsstatelijke redenen gekozen voor afstand van de uitvoerende macht tot de rechterlijke macht. Dit uit zich onder meer in de regel dat de kosten verbonden aan het eigenlijke rechtspreken (het primaire proces) vastgesteld moeten worden op grond van een objectieve meting van de werklast van de gerechten. De rechter bepaalt in beginsel de tijd die nodig is voor een goede en zorgvuldige behandeling van een zaak, met een prikkel tot doelmatig werken. De uitvoerende macht redeneert echter niet meer vanuit deze wettelijk verankerde norm. Steeds meer zijn generieke kortingen en begrotingsproblemen van het Ministerie van Veiligheid en Justitie leidend bij de financiering van de Rechtspraak. Deze praktijk is in strijd met de wet en tast de rechterlijke en institutionele onafhankelijkheid aan.

Published
2016

223. Functional single nucleotide polymorphisms within the cyclindependent kinase inhibitor 2A/2B region affect pancreatic cancer risk

Author

Campa, D. Pastore, M. Gentiluomo, M. Talar-Wojnarowska, R. Kupcinskas, J. Malecka-Panas, E. Neoptolemos, J.P. Niesen, W. Vodicka, P. Delle Fave, G. Bas Bueno-de-Mesquita, H. Gazouli, M. Pacetti, P. Di Leo, M. Ito, H. Klüter, H. Soucek, P. Corbo, V. Yamao, K. Hosono, S. Kaaks, R. Vashist, Y. Gioffreda, D. Strobel, O. Shimizu, Y. Dijk, F. Andriulli, A. Ivanauskas, A. Bugert, P. Tavano, F. Vodickova, L. Zambon, C.F. Lovecek, M. Landi, S. Key, T.J. Boggi, U. Pezzilli, R. Jamroziak, K. Mohelnikova-Duchonova, B. Mambrini, A. Bambi, F. Busch, O. Pazienza, V. Valente, R. Theodoropoulos, G.E. Hackert, T. Capurso, G. Cavestro, G.M. Pasquali, C. Basso, D. Sperti, C. Matsuo, K. Büchler, M. Khaw, K.-T. Izbicki, J. Costello, E. Katzke, V. Michalski, C. Stepien, A. Rizzato, C. Canzian, F.

Abstract

The CDKN2A (p16) gene plays a key role in pancreatic cancer etiology. It is one of the most commonly somatically mutated genes in pancreatic cancer, rare germline mutations have been found to be associated with increased risk of developing familiar pancreatic cancer and CDKN2A promoter hyper-methylation has been suggested to play a critical role both in pancreatic cancer onset and prognosis. In addition several unrelated SNPs in the 9p21.3 region, that includes the CDNK2A, CDNK2B and the CDNK2B-AS1 genes, are associated with the development of cancer in various organs. However, association between the common genetic variability in this region and pancreatic cancer risk is not clearly understood. We sought to fill this gap in a case-control study genotyping 13 single nucleotide polymorphisms (SNPs) in 2,857 pancreatic ductal adenocarcinoma (PDAC) patients and 6,111 controls in the context of the Pancreatic Disease Research (PANDoRA) consortium. We found that the A allele of the rs3217992 SNP was associated with an increased pancreatic cancer risk (ORhet=1.14, 95% CI 1.01-1.27, p=0.026, ORhom=1.30, 95% CI 1.12-1.51, p=0.00049). This pleiotropic variant is reported to be a mir-SNP that, by changing the binding site of one or more miRNAs, could influence the normal cell cycle progression and in turn increase PDAC risk. In conclusion, we observed a novel association in a pleiotropic region that has been found to be of key relevance in the susceptibility to various types of cancer and diabetes suggesting that the CDKN2A/B locus could represent a genetic link between diabetes and pancreatic cancer risk.

Published
2016

224. Functional polymorphisms in the CDKN2A generegion affect pancreatic cancer risk

Author

Canzian, F, Pastore, M, Gentiluomo, M, Pezzilli, R, Boggi, U, Delle Fave, G, Talar Wojnarowska, R, Kupcinskas, J, Strobel, O, Vodicka, P, Brenner, H, Khaw, Kt, Key, T, Landi, S, Tavano, F, Neoptolemos, J, Mambrini, A, Scarpa, A, Soucek, P, Gazouli, M, Milanetto, ANNA CATERINA, Rizzato, C, Vashist, Yk, Dijk, F, and Campa, D.

Published
2016

225. Report on Additional Materials and Instruments: ESPrIT Strengthening the Occupational Health Expertise and Scientific Capacity of Public Health Institution of Turkey

Author

Venema, A., Zoelen, S. van, Hermans, L., and Dijk, F. van

Subjects
Occupational health, Turkey, Life, Literature, WHC - Work, Health and Care, Work and Employment, Expertise, ELSS - Earth, Life and Social Sciences, Workplace, Healthy Living
Abstract

The aim of this report is to make an inventory of assets already available to fill the knowledge gaps amongst PHIT staff as indentified earlier. This report is the first step to provide PHIT with a repository of available literature, tools and instruments that can be used to increase their scientific knowledge on Occupational Health and Occupational diseases in particular. The repository will be used in WP 2 Scientific Capacity Building, WP3 ICD + Innovation and in WP 4 Scientific Excellence.

Published
2016

227. Education in Agricultural Health

Author

van Dijk, F. J. H., van der Laan, G., Verberk, M. M., Colosio, C., Coronel Institute of Occupational Health, and Other departments

Published
2016

228. Associations between the 17q21 region and allergic rhinitis in 5 birth cohorts

Author

Fuertes, Elaine, Söderhäll, Cilla, Acevedo, Nathalie, Becker, Allan, Brauer, Michael, Chan-Yeung, Moira, Dijk, F. Nicole, Heinrich, Joachim, de Jongste, Johan, Koppelman, Gerard H., Postma, Dirkje S., Kere, Juha, Kozyrskyj, Anita L., Pershagen, Göran, Sandford, Andrew, Standl, Marie, Tiesler, Carla M.T., Waldenberger, Melanie, Westman, Marit, Carlsten, Christopher, and Melén, Erik

Published
2015
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229. Clinical value of ctDNA in upper-GI cancers: A systematic review and meta-analysis

Author

Creemers, A., primary, Krausz, S., additional, Strijker, M., additional, van der Wel, M.J., additional, Soer, E.C., additional, Reinten, R.J., additional, Besselink, M.G., additional, Wilmink, J.W., additional, van de Vijver, M.J., additional, van Noesel, C.J.M., additional, Verheij, J., additional, Meijer, S.L., additional, Dijk, F., additional, Bijlsma, M.F., additional, van Oijen, M.G.H., additional, and van Laarhoven, H.W.M., additional

Published
2017
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230. Polymeric microspheres for the sustained release of a protein-based drug carrier targeting the PDGFβ-receptor in the fibrotic kidney

Author

Teekamp, N., primary, Van Dijk, F., additional, Broesder, A., additional, Evers, M., additional, Zuidema, J., additional, Steendam, R., additional, Post, E., additional, Hillebrands, J.L., additional, Frijlink, H.W., additional, Poelstra, K., additional, Beljaars, L., additional, Olinga, P., additional, and Hinrichs, W.L.J., additional

Published
2017
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232. Random-modulation CW lidar system for space-borne carbon dioxide remote sensing based on a high-brightness semiconductor laser

Author

Tijero, J. M. G., primary, Faugeron, M., primary, Van Dijk, F., primary, Traub, M., primary, Barbero, J., primary, Ai, X., primary, Quatrevalet, Mathieu, primary, Ehret, G., primary, Esquivias, I., primary, Pérez-Serrano, A., primary, Krakowski, M., primary, Kochem, G., primary, Adamiec, P., primary, and Rarity, J., primary

Published
2017
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236. Circulating levels of ADAM12, a stromal activation biomarker, are predictive of survival in pancreatic ductal adenocarcinoma (PDAC)

Author

van Laarhoven, H.W., primary, Damhofer, H., additional, Veenstra, V.L., additional, Waasdorp, C., additional, van Rijssen, L.B., additional, Dijk, F., additional, Wilmink, J.W., additional, Besselink, M.G., additional, Busch, O.R., additional, Medema, J.P., additional, Shiansong Li, J., additional, Jiang, R., additional, Pierce, D.W., additional, and Bijlsma, M.F., additional

Published
2017
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238. Rationale and design of the multiethnic Pharmacogenomics in Childhood Asthma consortium

Author

Farzan, Niloufar, primary, Vijverberg, Susanne J, additional, Andiappan, Anand K, additional, Arianto, Lambang, additional, Berce, Vojko, additional, Blanca-López, Natalia, additional, Bisgaard, Hans, additional, Bønnelykke, Klaus, additional, Burchard, Esteban G, additional, Campo, Paloma, additional, Canino, Glorisa, additional, Carleton, Bruce, additional, Celedón, Juan C, additional, Chew, Fook Tim, additional, Chiang, Wen Chin, additional, Cloutier, Michelle M, additional, Daley, Denis, additional, Den Dekker, Herman T, additional, Dijk, F Nicole, additional, Duijts, Liesbeth, additional, Flores, Carlos, additional, Forno, Erick, additional, Hawcutt, Daniel B, additional, Hernandez-Pacheco, Natalia, additional, de Jongste, Johan C, additional, Kabesch, Michael, additional, Koppelman, Gerard H, additional, Manolopoulos, Vangelis G, additional, Melén, Erik, additional, Mukhopadhyay, Somnath, additional, Nilsson, Sara, additional, Palmer, Colin N, additional, Pino-Yanes, Maria, additional, Pirmohamed, Munir, additional, Potočnki, Uros, additional, Raaijmakers, Jan A, additional, Repnik, Katja, additional, Schieck, Maximilian, additional, Sio, Yang Yie, additional, Smyth, Rosalind L, additional, Szalai, Csaba, additional, Tantisira, Kelan G, additional, Turner, Steve, additional, van der Schee, Marc P, additional, Verhamme, Katia M, additional, and Maitland-van der Zee, Anke H, additional

Published
2017
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242. Novel Algorithms for Improved Sensitivity in Non-Invasive Prenatal Testing

Author

Johansson, L. F., primary, de Boer, E. N., additional, de Weerd, H. A., additional, van Dijk, F., additional, Elferink, M. G., additional, Schuring-Blom, G. H., additional, Suijkerbuijk, R. F., additional, Sinke, R. J., additional, te Meerman, G. J., additional, Sijmons, R. H., additional, Swertz, M. A., additional, and Sikkema-Raddatz, B., additional

Published
2017
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243. Abstracts from the 3rd International Severe Asthma Forum (ISAF)

Author

Ketelaar, M. E., primary, Van De Kant, K., additional, Dijk, F. N., additional, Klaassen, E. M. M., additional, Grotenboer, N., additional, Nawijn, M. C., additional, Dompeling, E., additional, Koppelman, G. H., additional, Murray, Clare, additional, Foden, Philip, additional, Lowe, Lesley, additional, Durrington, Hannah, additional, Custovic, Adnan, additional, Simpson, Angela, additional, Simpson, Andrew J., additional, Shaw, Dominick E., additional, Sousa, Ana R., additional, Fleming, Louise J., additional, Roberts, Graham, additional, Pandis, Ioannis, additional, Bansal, Aruna T., additional, Corfield, Julie, additional, Wagers, Scott, additional, Djukanovic, Ratko, additional, Chung, Kian Fan, additional, Sterk, Peter J., additional, Vestbo, Jorgen, additional, Fowler, Stephen J., additional, Tebbutt, S. J., additional, Singh, A., additional, Shannon, C. P., additional, Kim, Y. W., additional, Yang, C. X., additional, Gauvreau, G. M., additional, Fitzgerald, J. M., additional, Boulet, L. P., additional, O’Byrne, P. M., additional, Begley, N., additional, Loudon, A., additional, Ray, D. W., additional, Baos, Selene, additional, Cremades, Lucía, additional, Calzada, David, additional, Lahoz, Carlos, additional, Cárdaba, Blanca, additional, Asosingh, Kewal, additional, Lauruschkat, Chris, additional, Queisser, Kimberly, additional, Wanner, Nicholas, additional, Weiss, Kelly, additional, Xu, Weiling, additional, Erzurum, Serpil, additional, Sokolowska, Milena, additional, Chen, Li-Yuan, additional, Liu, Yueqin, additional, Martinez-Anton, Asuncion, additional, Logun, Carolea, additional, Alsaaty, Sara, additional, Cuento, Rosemarie, additional, Cai, Rongman, additional, Sun, Junfeng, additional, Quehenberger, Oswald, additional, Armando, Aaron, additional, Dennis, Edward, additional, Levine, Stewart, additional, Shelhamer, James, additional, Choi, Kilyong, additional, Lazova, Snezhina, additional, Perenovska, Penka, additional, Miteva, Dimitrinka, additional, Priftis, Stamatios, additional, Petrova, Guergana, additional, Yablanski, Vassil, additional, Vlaev, Evgeni, additional, Rafailova, Hristina, additional, Kumae, Takashi, additional, Holmes, L. J., additional, Yorke, J., additional, Ryan, D. M., additional, Chinratanapisit, Sasawan, additional, Matchimmadamrong, Khlongtip, additional, Deerojanawong, Jitladda, additional, Karoonboonyanan, Wissaroot, additional, Sritipsukho, Paskorn, additional, Youroukova, Vania, additional, Dimitrova, Denitsa, additional, Slavova, Yanina, additional, Lesichkova, Spaska, additional, Tzocheva, Iren, additional, Parina, Snezhana, additional, Angelova, Svetla, additional, Korsun, Neli, additional, Craiu, Mihai, additional, Stan, Iustina Violeta, additional, Deliu, Matea, additional, Yavuz, Tolga, additional, Sperrin, Matthew, additional, Sahiner, Umit M., additional, Belgrave, Danielle, additional, Sackesen, Cansin Sackesen, additional, Kalayci, Ömer, additional, Velikov, Petar, additional, Velikova, Tsvetelina, additional, Ivanova-Todorova, Ekaterina, additional, Tumangelova-Yuzeir, Kalina, additional, Kyurkchiev, Dobroslav, additional, Megremis, Spyridon, additional, Constantinides, Bede, additional, Sotiropoulos, Alexandros Georgios, additional, Xepapadaki, Paraskevi, additional, Robertson, David, additional, Papadopoulos, Nikolaos, additional, Wilkinson, Maxim, additional, Portsmouth, Craig, additional, Ray, David, additional, Goodacre, Royston, additional, Valerieva, Anna, additional, Bobolea, Irina, additional, Vera, Daiana Guillén, additional, Gonzalez-Salazar, Gabriel, additional, Moreno, Carlos Melero, additional, Rodriguez, Consuelo Fernandez, additional, De Las Cuevas Moreno, Natividad, additional, Wang, R., additional, Satia, I., additional, Niven, R., additional, Smith, J. A., additional, Southworth, T., additional, Plumb, J., additional, Gupta, V., additional, Pearson, J., additional, Ramis, I., additional, Lehner, M. D., additional, Miralpeix, M., additional, Singh, D., additional, Satia, Imran, additional, Woodhead, Mark, additional, O’Byrne, Paul, additional, Smith, Jaclyn Ann, additional, Forss, Cecilia, additional, Cook, Peter, additional, Brown, Sheila, additional, Svedberg, Freya, additional, Stephenson, Katherine, additional, Bertuzzi, Margherita, additional, Bignell, Elaine, additional, Enerbäck, Malin, additional, Cunoosamy, Danen, additional, Macdonald, Andrew, additional, Liu, Caini, additional, Zhu, Liang, additional, Fukuda, Kiochi, additional, Zhang, Cunjin, additional, Ouyang, Suidong, additional, Chen, Xing, additional, Qin, Luke, additional, Rachakonda, Suguna, additional, Aronica, Mark, additional, Qin, Jun, additional, Li, Xiaoxia, additional, Larose, Marie-Chantal, additional, Archambault, Anne-Sophie, additional, Provost, Véronique, additional, Chakir, Jamila, additional, Laviolette, Michel, additional, Flamand, Nicolas, additional, Logan, Nicola, additional, Ruckerl, Dominik, additional, Allen, Judith E., additional, Sutherland, Tara E., additional, Hamelmann, E., additional, Vogelberg, C., additional, Goldstein, S., additional, Azzi, G. E., additional, Engel, M., additional, Sigmund, R., additional, Szefler, S. J., additional, Mesquita, Raquel, additional, Coentrão, Luis, additional, Veiga, Rui, additional, Paiva, José-Artur, additional, Roncon-Albuquerque, Roberto, additional, Porras, Wendy Vargas, additional, Moreno, Ana González, additional, Iglesias, Jesus Macías, additional, Ramos, Gustavo Córdova, additional, Acevedo, Yesenia Peña, additional, Alonso, Miguel Angel Tejedor, additional, Del Mar Moro Moro, Maria, additional, Krcmova, Irena, additional, Novosad, Jakub, additional, Hanania, Nicola Alexander, additional, Massanari, Marc, additional, Hecker, Heike, additional, Kassel, Eric, additional, Laforce, Craig, additional, Rickard, Kathy, additional, Snelder, Sanne, additional, Braunstahl, Gert-Jan, additional, Jones, T. L., additional, Neville, D., additional, Heiden, E. R., additional, Lanning, E., additional, Brown, T., additional, Rupani, H., additional, Babu, K. S., additional, Chauhan, A. J., additional, Eldegeir, M. Y., additional, Chapman, A. A., additional, Ferwana, M., additional, and Caldron, M., additional

Published
2017
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245. Correction: Time-Dependent Impact of Irreversible Electroporation on Pancreas, Liver, Blood Vessels and Nerves: A Systematic Review of Experimental Studies

Author

Vogel, J. A., primary, van Veldhuisen, E., additional, Agnass, P., additional, Crezee, J., additional, Dijk, F., additional, Verheij, J., additional, van Gulik, T. M., additional, Meijerink, M. R., additional, Vroomen, L. G., additional, van Lienden, K. P., additional, and Besselink, M. G., additional

Published
2017
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246. Genome-wide patterns and properties of de novo mutations in humans

Author

Francioli, L.C., Polak, P.P., Koren, A., Menelaou, A., Chun, S., Renkens, I., van Duijn, C.M., Swertz, M.A., Wijmenga, C., van Ommen, G.J., Slagboom, P.E., Boomsma, D.I., Ye, K., Guryev, V., Arndt, P.F., Kloosterman, W.P., Bakker, P.I.W., Sunyaev, S.R., Dijk, F., Neerincx, P.B.T., Pulit, S.L., Deelen, P., Elbers, C.C., Palamara, P.F., Pe'er, I., Abdellaoui, A., van Oven, M., Vermaat, M., Li, M., Laros, J.F.J., Stoneking, M., de Knijff, P., Kayser, M., Veldink, J.H., Van den Berg, L.H., Byelas, H., den Dunnen, J.T., Dijkstra, M., Amin, N., van der Velde, K.J., Hottenga, J.J., van Setten, J., van Leeuwen, E.M., Kanterakis, A., Kattenberg, V.M., Karssen, L.C., van Schaik, B.D.C., Bot, J., Nijman, I.J., van Enckevort, D., Mei, H., Koval, V., Estrada, K., Medina-Gomez, C., Lameijer, E.W., Moed, M.H., Hehir-Kwa, J.Y., Handsaker, R.E., McCarroll, S.A., Vuzman, D., Sohail, M., Hormozdiari, F., Marschall, T., Schönhuth, A., Beekman, M., de Craen, A.J., Suchiman, H.E.D., Hofman, A., Oostra, B., Isaacs, A., Rivadeneira, F., Uitterlinden, A.G., Willemsen, G., Platteel, M., Pitts, S.J., Potluri, S., Sundar, P., Cox, D.R., Li, Q., Li, Y., Du, Y., Chen, R., Cao, H., Li, N., Cao, S., Wang, J., Bovenberg, J.A., Brandsma, M., Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Stem Cell Aging Leukemia and Lymphoma (SALL), Groningen Research Institute for Asthma and COPD (GRIAC), Biological Psychology, Culture, Organization and Management, Neuroscience Campus Amsterdam - Neurobiology of Mental Health, Epidemiology, and Pharmacy

Subjects
Male, Netherlands Twin Register (NTR), Mutation rate, Population genetics, Twin Study, DISEASE, Nucleotide diversity, 0302 clinical medicine, Mutation Rate, ELEMENTS, Non-U.S. Gov't, POPULATION, Genetics, 0303 health sciences, education.field_of_study, Research Support, Non-U.S. Gov't, SUBSTITUTION, Mutation (genetic algorithm), Female, Pan troglodytes, Population, DNA-SEQUENCING DATA, Mutagenesis (molecular biology technique), Biology, Research Support, Article, Paternal Age, N.I.H, Evolution, Molecular, 03 medical and health sciences, Germline mutation, SDG 3 - Good Health and Well-being, Research Support, N.I.H., Extramural, Journal Article, Animals, Humans, education, Germ-Line Mutation, 030304 developmental biology, Models, Genetic, Genome, Human, Extramural, FRAMEWORK, POLYMORPHISM, RECOMBINATION RATES, RESOLUTION, RADIATION, Human genome, 030217 neurology & neurosurgery
Abstract

Mutations create variation in the population, fuel evolution and cause genetic diseases. Current knowledge about de novo mutations is incomplete and mostly indirect(1-10). Here we analyze 11,020 de novo mutations from the whole genomes of 250 families. We show that de novo mutations in the offspring of older fathers are not only more numerous(11-13) but also occur more frequently in early-replicating, genic regions. Functional regions exhibit higher mutation rates due to CpG dinucleotides and show signatures of transcriptioncoupled repair, whereas mutation clusters with a unique signature point to a new mutational mechanism. Mutation and recombination rates independently associate with nucleotide diversity, and regional variation in human-chimpanzee divergence is only partly explained by heterogeneity in mutation rate. Finally, we provide a genome-wide mutation rate map for medical and population genetics applications. Our results provide new insights and refine long-standing hypotheses about human mutagenesis.

Published
2015
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247. Monolithic dual-wavelength DFB lasers for the generation of opticallycarried RF local oscillators

Author

Romanelli, Marco, van Dijk, F., Wang, L., Vallet, Marc, Institut de Physique de Rennes (IPR), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS), Alcatel-Thalès III-V lab (III-V Lab), THALES-ALCATEL, Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS), and THALES [France]-ALCATEL

Subjects
[PHYS]Physics [physics], ComputingMilieux_MISCELLANEOUS
Abstract

International audience; [No abstract available]

Published
2015

248. Genome of the Netherlands population-specific imputations identify an ABCA6 variant associated with cholesterol levels

Author

Van Leeuwen, EM, Karssen, LC, Deelen, J, Isaacs, A, Medina-Gomez, C, Mbarek, H, Kanterakis, A, Trompet, S, Postmus, I, Verweij, N, Van Enckevort, DJ, Huffman, JE, White, CC, Feitosa, MF, Bartz, TM, Manichaikul, A, Joshi, PK, Peloso, GM, Deelen, P, Van Dijk, F, Willemsen, G, De Geus, EJ, Milaneschi, Y, Penninx, BWJH, Francioli, LC, Menelaou, A, Pulit, SL, Rivadeneira, F, Hofman, A, Oostra, BA, Franco, OH, Leach, IM, Beekman, M, De Craen, AJM, Uh, HW, Trochet, H, Hocking, LJ, Porteous, DJ, Sattar, N, Packard, CJ, Buckley, BM, Brody, JA, Bis, JC, Rotter, JI, Mychaleckyj, JC, Campbell, H, Duan, Q, Lange, LA, Wilson, JF, Hayward, C, Polasek, O, Vitart, V, Rudan, I, Wright, AF, Rich, SS, Psaty, BM, Borecki, IB, Kearney, PM, Stott, DJ, Cupples, LA, Jukema, JW, Van Der Harst, P, Sijbrands, EJ, Hottenga, JJ, Uitterlinden, AG, Swertz, MA, Van Ommen, GJB, De Bakker, PIW, Eline Slagboom, P, Boomsma, DI, Wijmenga, C, Van Duijn, CM, Neerincx, PBT, Elbers, CC, Palamara, PF, Peer, I, Abdellaoui, A, Kloosterman, WP, Van Oven, M, Vermaat, M, Li, M, Laros, JFJ, Stoneking, M, De Knijff, P, Kayser, M, Veldink, JH, Van Den Berg, LH, Byelas, H, Den Dunnen, JT, Dijkstra, M, Amin, N, Van Der Velde, KJ, and Van Setten, J

Abstract

© 2015 Macmillan Publishers Limited. All rights reserved. Variants associated with blood lipid levels may be population-specific. To identify low-frequency variants associated with this phenotype, population-specific reference panels may be used. Here we impute nine large Dutch biobanks (∼35,000 samples) with the population-specific reference panel created by the Genome of the Netherlands Project and perform association testing with blood lipid levels. We report the discovery of five novel associations at four loci (P value

Published
2015
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249. LIDAR System based on a High Brightness Semiconductor Laser and Single Photon Counting Detection for Space -borne Atmospheric CO2 Monitoring

Author

Esquivias Moscardo, Ignacio, Pérez Serrano, Antonio, Garcia Tijero, Jose Manuel, Faugeron, M., Krakowski, M., van Dijk, F., Kochem, G., Traub, M., Adamiec, Pawel, Barbero, Juan, Ai, Xiao, Rarity, John, Quatrevalet, Mathieu, and Ehret, Gerhard

Subjects
Telecomunicaciones, Matemáticas, Physics::Optics
Abstract

We theoretically investigate a dynamical regime, experimentally observed in monolithically integrated master oscillator power amplifiers emitting at 1.5 7 μm, consisting in large emission wavelength jumps of the device from the Bragg wavelength to that of the gain peak. Our analysis is based on numerical simulations by means of a travelling wave model that incorporates spatial effects such as spatial hole burning and coupled-cavity effects. Thermal effects are included by considering the optical response of the quantum well active medium within the quasi-equilibrium approximation at finite temperature, with a phenomenological description of the redshift of the gain peak and the changes in the background material refractive index by means of self- and cross-heating coefficients for both sections. We find that whereas the thermally-induced index changes are the responsible of the modal jumps between consecutive modes, the carrier-induced refractive index changes are the responsible of the jumps occurring between the Bragg wavelength and the gain peak.

Published
2015

250. Zes Suggesties voor Verbetering van de Toegang tot Recht

Author

Brenninkmeijer, A., Baarsma, B., Schouten, C., de Wijs, E., Kortlang, E., van der Molen, E., van Dijk, F., Hofhuis, H., Winter, J., Slagter, J.M., Moerland, J., Sewalt, J., van Beek, K., Verheij, L., Snoep, M., Barendrecht, M., van den Oord, M., Scheltema, M., van Oostrom-Streep, N., van Veldhuizen, O., van Klinken, P., van der Meer Mohr, P., Harchaoui, S., Muller, S., and SEO Economisch Onderzoek

Published
2015

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