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758 results on '"Diatchenko, Luda"'

201. The nicotinic α6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors

Author

Wieskopf, Jeffrey S., primary, Mathur, Jayanti, additional, Limapichat, Walrati, additional, Post, Michael R., additional, Al-Qazzaz, Mona, additional, Sorge, Robert E., additional, Martin, Loren J., additional, Zaykin, Dmitri V., additional, Smith, Shad B., additional, Freitas, Kelen, additional, Austin, Jean-Sebastien, additional, Dai, Feng, additional, Zhang, Jie, additional, Marcovitz, Jaclyn, additional, Tuttle, Alexander H., additional, Slepian, Peter M., additional, Clarke, Sarah, additional, Drenan, Ryan M., additional, Janes, Jeff, additional, Al Sharari, Shakir, additional, Segall, Samantha K., additional, Aasvang, Eske K., additional, Lai, Weike, additional, Bittner, Reinhard, additional, Richards, Christopher I., additional, Slade, Gary D., additional, Kehlet, Henrik, additional, Walker, John, additional, Maskos, Uwe, additional, Changeux, Jean-Pierre, additional, Devor, Marshall, additional, Maixner, William, additional, Diatchenko, Luda, additional, Belfer, Inna, additional, Dougherty, Dennis A., additional, Su, Andrew I., additional, Lummis, Sarah C. R., additional, Imad Damaj, M., additional, Lester, Henry A., additional, Patapoutian, Ardem, additional, and Mogil, Jeffrey S., additional

Published
2015
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202. Carbonic Anhydrase-8 Regulates Inflammatory Pain by Inhibiting the ITPR1-Cytosolic Free Calcium Pathway

Author

Zhuang, Gerald Z., primary, Keeler, Benjamin, additional, Grant, Jeff, additional, Bianchi, Laura, additional, Fu, Eugene S., additional, Zhang, Yan Ping, additional, Erasso, Diana M., additional, Cui, Jian-Guo, additional, Wiltshire, Tim, additional, Li, Qiongzhen, additional, Hao, Shuanglin, additional, Sarantopoulos, Konstantinos D., additional, Candiotti, Keith, additional, Wishnek, Sarah M., additional, Smith, Shad B., additional, Maixner, William, additional, Diatchenko, Luda, additional, Martin, Eden R., additional, and Levitt, Roy C., additional

Published
2015
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203. Expansion of the human μ-opioid receptor gene architecture: novel functional variants

Author

Diatchenko, Luda, Staud, Roland, Zaykin, Dmitri V., Fillingim, Roger B., Gauthier, Josee, Wallace, Margaret R., Tchivileva, Inna E., Shabalina, Svetlana A., Spiridonov, Nikolay A., Mishra, Bikashkumar, Goldman, David, Belfer, Inna, Shibata, Kyoko, Ogurtsov, Aleksey Y., Gris, Pavel, Kiselycznyk, Carly, Maixner, William, and Max, Mitchell B.

Abstract

The μ-opioid receptor (OPRM1) is the principal receptor target for both endogenous and exogenous opioid analgesics. There are substantial individual differences in human responses to painful stimuli and to opiate drugs that are attributed to genetic variations in OPRM1. In searching for new functional variants, we employed comparative genome analysis and obtained evidence for the existence of an expanded human OPRM1 gene locus with new promoters, alternative exons and regulatory elements. Examination of polymorphisms within the human OPRM1 gene locus identified strong association between single nucleotide polymorphism (SNP) rs563649 and individual variations in pain perception. SNP rs563649 is located within a structurally conserved internal ribosome entry site (IRES) in the 5′-UTR of a novel exon 13-containing OPRM1 isoforms (MOR-1K) and affects both mRNA levels and translation efficiency of these variants. Furthermore, rs563649 exhibits very strong linkage disequilibrium throughout the entire OPRM1 gene locus and thus affects the functional contribution of the corresponding haplotype that includes other functional OPRM1 SNPs. Our results provide evidence for an essential role for MOR-1K isoforms in nociceptive signaling and suggest that genetic variations in alternative OPRM1 isoforms may contribute to individual differences in opiate responses.

Published
2009
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204. Catechol-O-methyltransferase inhibition increases pain sensitivity through activation of both β2- and β3-adrenergic receptors

Author

Fecho, Karamarie, Tan, Kai Soo, Diatchenko, Luda, Flood, Patrick, Nackley, Andrea Gail, and Maixner, William

Subjects
nervous system, mental disorders, fungi, behavioral disciplines and activities
Abstract

Catechol-O-methyltransferase (COMT), an enzyme that metabolizes catecholamines, has recently been implicated in the modulation of pain. Our group demonstrated that human genetic variants of COMT are predictive for the development of Temporomandibular Joint Disorder (TMJD) and are associated with heightened experimental pain sensitivity (Diatchenko et al. 2005). Variants associated with heightened pain sensitivity produce lower COMT activity. Here we report the mechanisms underlying COMT-dependent pain sensitivity. To characterize the means whereby elevated catecholamine levels, resulting from reduced COMT activity, modulate heightened pain sensitivity, we administered a COMT inhibitor to rats and measured behavioral responsiveness to mechanical and thermal stimuli. We show that depressed COMT activity results in enhanced mechanical and thermal pain sensitivity. This phenomenon is completely blocked by the nonselective β-adrenergic antagonist propranolol or by the combined administration of selective β2- and β3-adrenergic antagonists, while administration of β1-adrenergic, α-adrenergic, or dopaminergic receptor antagonists fail to alter COMT-dependent pain sensitivity. These data provide the first direct evidence that low COMT activity leads to increased pain sensitivity via a β2/3-adrenergic mechanism. These findings are of considerable clinical importance, suggesting that pain conditions resulting from low COMT activity and/or elevated catecholamine levels can be treated with pharmacological agents that block both β2- and β3-adrenergic receptors.

Published
2007
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212. Human carbonic anhydrase-8 AAV8 gene therapy inhibits nerve growth factor signaling producing prolonged analgesia and anti-hyperalgesia in mice

Author

Zhuang, Gerald, Upadhyay, Udita, Tong, Xiaoying, Kang, Yuan, Erasso, Diana, Fu, Eugene, Sarantopoulos, Konstantinos, Martin, Eden, Wiltshire, Tim, Diatchenko, Luda, Smith, Shad, Maixner, William, and Levitt, Roy

Abstract

Carbonic anhydrase-8 (Car8; murine gene symbol) is an allosteric inhibitor of inositol trisphosphate receptor-1 (ITPR1), which regulates neuronal intracellular calcium release. We previously reported that wild-type Car8 overexpression corrects the baseline allodynia and hyperalgesia associated with calcium dysregulation in the waddle (wdl) mouse due to a 19 bp deletion in exon 8 of the Car8gene. In this report, we provide preliminary evidence that overexpression of the human wild-type ortholog of Car8(CA8WT), but not the reported CA8S100P loss-of-function mutation (CA8MT), inhibits nerve growth factor (NGF)-induced phosphorylation of ITPR1, TrkA (NGF high-affinity receptor), and ITPR1-mediated cytoplasmic free calcium release in vitro. In addition, we show that gene transfer using AAV8-V5-CA8WTviral particles via sciatic nerve injection demonstrates retrograde transport to dorsal root ganglia (DRG) producing prolonged V5-CA8WTexpression, pITPR1 and pTrkA inhibition, and profound analgesia and anti-hyperalgesia in male C57BL/6J mice. AAV8-V5-CA8WT-mediated overexpression prevented and treated allodynia and hyperalgesia associated with chronic neuropathic pain produced by the spinal nerve ligation (SNL) model. These AAV8-V5-CA8 data provide a proof-of-concept for precision medicine through targeted gene therapy of NGF-responsive somatosensory neurons as a long-acting local analgesic able to prevent and treat chronic neuropathic pain through regulating TrkA signaling, ITPR1 activation, and intracellular free calcium release by ITPR1.

Published
2018
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213. A Genome-wide Drosophila Screen for Heat Nociception Identifies alpha 2 delta 3 as an Evolutionarily Conserved Pain Gene

Author

Neely, G Gregory, Hess, Andreas, Costigan, Michael, Keene, Alex C, Goulas, Spyros, Langeslag, Michiel, Griffin, Robert S, Belfer, Inna, Dai, Feng, Smith, Shad B, Diatchenko, Luda, Gupta, Vaijayanti, Xia, Cui-Ping, Amann, Sabina, Kreitz, Silke, Heindl-Erdmann, Cornelia, Wolz, Susanne, Ly, Cindy V, Sarangi, Rinku, Dan, Debasis, Novatchkova, Maria, Rosenzweig, Mark, Gibson, Dustin G, Truong, Darwin, Schramek, Daniel, Zoranovic, Tamara, Cronin, Shane J F, Angjeli, Belinda, Brune, Kay, Dietzl, Georg, Maixner, William, Meixner, Arabella, Thomas, Winston, Pospisilik, J Andrew, Alenius, Mattias, Kress, Michaela, Subramaniam, Sai, Garrity, Paul A, Bellen, Hugo J, Woolf, Clifford J, Penninger, Josef M, Neely, G Gregory, Hess, Andreas, Costigan, Michael, Keene, Alex C, Goulas, Spyros, Langeslag, Michiel, Griffin, Robert S, Belfer, Inna, Dai, Feng, Smith, Shad B, Diatchenko, Luda, Gupta, Vaijayanti, Xia, Cui-Ping, Amann, Sabina, Kreitz, Silke, Heindl-Erdmann, Cornelia, Wolz, Susanne, Ly, Cindy V, Sarangi, Rinku, Dan, Debasis, Novatchkova, Maria, Rosenzweig, Mark, Gibson, Dustin G, Truong, Darwin, Schramek, Daniel, Zoranovic, Tamara, Cronin, Shane J F, Angjeli, Belinda, Brune, Kay, Dietzl, Georg, Maixner, William, Meixner, Arabella, Thomas, Winston, Pospisilik, J Andrew, Alenius, Mattias, Kress, Michaela, Subramaniam, Sai, Garrity, Paul A, Bellen, Hugo J, Woolf, Clifford J, and Penninger, Josef M

Abstract

Worldwide, acute, and chronic pain affects 20% of the adult population and represents an enormous financial and emotional burden. Using genome-wide neuronal-specific RNAi knockdown in Drosophila, we report a global screen for an innate behavior and identify hundreds of genes implicated in heat nociception, including the alpha 2 delta family calcium channel subunit straightjacket (stj). Mice mutant for the stj ortholog CACNA2D3 (alpha 2 delta 3) also exhibit impaired behavioral heat pain sensitivity. In addition, in humans, alpha 2 delta 3 SNP variants associate with reduced sensitivity to acute noxious heat and chronic back pain. Functional imaging in alpha 2 delta 3 mutant mice revealed impaired transmission of thermal pain-evoked signals from the thalamus to higher-order pain centers. Intriguingly, in alpha 2 delta 3 mutant mice, thermal pain and tactile stimulation triggered strong cross-activation, or synesthesia, of brain regions involved in vision, olfaction, and hearing.

Published
2010
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214. Carbonic anhydrase-8 gene therapy inhibits the ITPR1-cytosolic free calcium pathway producing analgesia and anti-hyperalgesia

Author

Levitt, Roy C, primary, Zhuang, Gerald Z, additional, Keeler, Benjamin, additional, Grant, Jeff, additional, Bianchi, Laura, additional, Fu, Eugene S, additional, Zhang, Yan Ping, additional, Erasso, Diana M, additional, Cui, Jian Guo, additional, Wiltshire, Tim, additional, Li, Qiongzhen, additional, Hao, Shuanglin, additional, Sarantopoulos, Konstantinos D, additional, Candiotti, Keith, additional, Smith, Shad B, additional, Maixner, William, additional, Diatchenko, Luda, additional, and Martin, Eden R, additional

Published
2014
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217. Summary of Findings From the OPPERA Prospective Cohort Study of Incidence of First-Onset Temporomandibular Disorder: Implications and Future Directions

Author

Slade, Gary D., primary, Fillingim, Roger B., additional, Sanders, Anne E., additional, Bair, Eric, additional, Greenspan, Joel D., additional, Ohrbach, Richard, additional, Dubner, Ronald, additional, Diatchenko, Luda, additional, Smith, Shad B., additional, Knott, Charles, additional, and Maixner, William, additional

Published
2013
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219. Study Protocol, Sample Characteristics, and Loss to Follow-Up: The OPPERA Prospective Cohort Study

Author

Bair, Eric, primary, Brownstein, Naomi C., additional, Ohrbach, Richard, additional, Greenspan, Joel D., additional, Dubner, Ronald, additional, Fillingim, Roger B., additional, Maixner, William, additional, Smith, Shad B., additional, Diatchenko, Luda, additional, Gonzalez, Yoly, additional, Gordon, Sharon M., additional, Lim, Pei-Feng, additional, Ribeiro-Dasilva, Margarete, additional, Dampier, Dawn, additional, Knott, Charles, additional, and Slade, Gary D., additional

Published
2013
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220. Clinical Orofacial Characteristics Associated With Risk of First-Onset TMD: The OPPERA Prospective Cohort Study

Author

Ohrbach, Richard, primary, Bair, Eric, additional, Fillingim, Roger B., additional, Gonzalez, Yoly, additional, Gordon, Sharon M., additional, Lim, Pei-Feng, additional, Ribeiro-Dasilva, Margarete, additional, Diatchenko, Luda, additional, Dubner, Ronald, additional, Greenspan, Joel D., additional, Knott, Charles, additional, Maixner, William, additional, Smith, Shad B., additional, and Slade, Gary D., additional

Published
2013
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222. Facial pain with localized and widespread manifestations: Separate pathways of vulnerability

Author

Slade, Gary D., primary, Smith, Shad B., additional, Zaykin, Dmitri V., additional, Tchivileva, Inna E., additional, Gibson, Dustin G., additional, Yuryev, Anton, additional, Mazo, Ilya, additional, Bair, Eric, additional, Fillingim, Roger, additional, Ohrbach, Richard, additional, Greenspan, Joel, additional, Maixner, William, additional, and Diatchenko, Luda, additional

Published
2013
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225. Pain modality- and sex-specific effects of COMT genetic functional variants

Author

Belfer, Inna, primary, Segall, Samantha K., additional, Lariviere, William R., additional, Smith, Shad B., additional, Dai, Feng, additional, Slade, Gary D., additional, Rashid, Naim U., additional, Mogil, Jeffrey S., additional, Campbell, Claudia M., additional, Edwards, Robert R., additional, Liu, Qian, additional, Bair, Eric, additional, Maixner, William, additional, and Diatchenko, Luda, additional

Published
2013
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226. Polymorphisms in the glucocorticoid receptor co-chaperone FKBP5 predict persistent musculoskeletal pain after traumatic stress exposure

Author

Bortsov, Andrey V., primary, Smith, Jennifer E., additional, Diatchenko, Luda, additional, Soward, April C., additional, Ulirsch, Jacob C., additional, Rossi, Catherine, additional, Swor, Robert A., additional, Hauda, William E., additional, Peak, David A., additional, Jones, Jeffrey S., additional, Holbrook, Debra, additional, Rathlev, Niels K., additional, Foley, Kelly A., additional, Lee, David C., additional, Collette, Renee, additional, Domeier, Robert M., additional, Hendry, Phyllis L., additional, and McLean, Samuel A., additional

Published
2013
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229. Human Genetic Variability Contributes to Postoperative Morphine Consumption.

Author

De Gregori, Manuela, Diatchenko, Luda, Ingelmo, Pablo M., Napolioni, Valerio, Klepstad, Pal, Belfer, Inna, Molinaro, Valeria, Garbin, Giulia, Ranzani, Guglielmina N., Alberio, Giovanni, Normanno, Marco, Lovisari, Federica, Somaini, Marta, Govoni, Stefano, Mura, Elisa, Bugada, Dario, Niebel, Thekla, Zorzetto, Michele, De Gregori, Simona, and Molinaro, Mariadelfina

Abstract

Unlabelled: High interindividual variability in postoperative opioid consumption is related to genetic and environmental factors. We tested the association between morphine consumption, postoperative pain, and single nucleotide polymorphisms (SNPs) within opioid receptor μ 1 (OPRM1), catechol-O-methyltransferase (COMT), uridine diphosphate glucose-glucuronosyltransferase-2B7, and estrogen receptor (ESR1) gene loci to elucidate genetic prediction of opioid consumption. We analyzed 20 SNPs in 201 unrelated Caucasian patients who underwent abdominal surgery and who were receiving postoperative patient-controlled analgesia-administered morphine. Morphine consumption and pain intensity were dependent variables; age and sex were covariates. A haplotype of 7 SNPs in OPRM1 showed significant additive effects on opioid consumption (P = .007); a linear regression model including age and 9 SNPs in ESR1, OPRM1, and COMT explained the highest proportion of variance of morphine consumption (10.7%; P = .001). The minimal model including 3 SNPs in ESR1, OPRM1, and COMT explained 5% of variance (P = .007). We found a significant interaction between rs4680 in COMT and rs4986936 in ESR1 (P = .007) on opioid consumption. SNPs rs677830 and rs540825 of OPRM1 and rs9340799 of ESR1 were nominally associated with pain Numeric Rating Scale scores. Combinations of genetic variants within OPRM1, COMT, and ESR1 better explain variability in morphine consumption than single genetic variants. Our results contribute to the development of genetic markers and statistical models for future diagnostic tools for opioid consumption/efficacy.Perspective: This article presents the efforts dedicated to detect correlations between the genetic polymorphisms and the clinical morphine effect self-administered by patients using a patient-controlled analgesia pump after major surgery. The clinical effect is expressed in terms of morphine consumption and pain scores. REGISTERED ON CLINICALTRIALS.GOV: NCT01233752. [ABSTRACT FROM AUTHOR]

Published
2016
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231. Construction of a Global Pain Systems Network Highlights Phospholipid Signaling as a Regulator of Heat Nociception

Author

Neely, G. Gregory, primary, Rao, Shuan, additional, Costigan, Michael, additional, Mair, Norbert, additional, Racz, Ildiko, additional, Milinkeviciute, Giedre, additional, Meixner, Arabella, additional, Nayanala, Swetha, additional, Griffin, Robert S., additional, Belfer, Inna, additional, Dai, Feng, additional, Smith, Shad, additional, Diatchenko, Luda, additional, Marengo, Stefano, additional, Haubner, Bernhard J., additional, Novatchkova, Maria, additional, Gibson, Dustin, additional, Maixner, William, additional, Pospisilik, J. Andrew, additional, Hirsch, Emilio, additional, Whishaw, Ian Q., additional, Zimmer, Andreas, additional, Gupta, Vaijayanti, additional, Sasaki, Junko, additional, Kanaho, Yasunori, additional, Sasaki, Takehiko, additional, Kress, Michaela, additional, Woolf, Clifford J., additional, and Penninger, Josef M., additional

Published
2012
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233. Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity

Author

Sorge, Robert E, primary, Trang, Tuan, additional, Dorfman, Ruslan, additional, Smith, Shad B, additional, Beggs, Simon, additional, Ritchie, Jennifer, additional, Austin, Jean-Sebastien, additional, Zaykin, Dmitri V, additional, Meulen, Heather Vander, additional, Costigan, Michael, additional, Herbert, Teri A, additional, Yarkoni-Abitbul, Merav, additional, Tichauer, David, additional, Livneh, Jessica, additional, Gershon, Edith, additional, Zheng, Ming, additional, Tan, Keith, additional, John, Sally L, additional, Slade, Gary D, additional, Jordan, Joanne, additional, Woolf, Clifford J, additional, Peltz, Gary, additional, Maixner, William, additional, Diatchenko, Luda, additional, Seltzer, Ze'ev, additional, Salter, Michael W, additional, and Mogil, Jeffrey S, additional

Published
2012
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234. Catechol-O-Methyltransferase Genotype Predicts Pain Severity in Hospitalized Burn Patients

Author

Orrey, Danielle C., primary, Bortsov, Andrey V., additional, Hoskins, Janelle M., additional, Shupp, Jeffrey W., additional, Jones, Samuel W., additional, Cicuto, Bryan J., additional, Hwang, James, additional, Jordan, Marion H., additional, Holmes, James H., additional, Haith, Linwood R., additional, Roane, Brandon M., additional, Diatchenko, Luda, additional, Cairns, Bruce A., additional, and McLean, Samuel A., additional

Published
2012
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236. Effect of Human Genetic Variability on Gene Expression in Dorsal Root Ganglia and Association with Pain Phenotypes

Author

Parisien, Marc, Khoury, Samar, Chabot-Doré, Anne-Julie, Sotocinal, Susana G., Slade, Gary D., Smith, Shad B., Fillingim, Roger B., Ohrbach, Richard, Greenspan, Joel D., Maixner, William, Mogil, Jeffrey S., Belfer, Inna, and Diatchenko, Luda

Abstract

Dorsal root ganglia (DRG) relay sensory information to the brain, giving rise to the perception of pain, disorders of which are prevalent and burdensome. Here, we mapped expression quantitative trait loci (eQTLs) in a collection of human DRGs. DRG eQTLs were enriched within untranslated regions of coding genes of low abundance, with some overlapping with other brain regions and blood cell cis-eQTLs. We confirm functionality of identified eQTLs through their significant enrichment within open chromatin and highly deleterious SNPs, particularly at the exon level, suggesting substantial contribution of eQTLs to alternative splicing regulation. We illustrate pain-related genetic association results explained by DRG eQTLs, with the strongest evidence for contribution of the human leukocyte antigen (HLA) locus, confirmed using a mouse inflammatory pain model. Finally, we show that DRG eQTLs are found among hits in numerous genome-wide association studies, suggesting that this dataset will help address pain components of non-pain disorders.

Published
2017
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237. Cytokine biomarkers and chronic pain: Association of genes, transcription, and circulating proteins with temporomandibular disorders and widespread palpation tenderness

Author

Slade, Gary D., primary, Conrad, Mathew S., additional, Diatchenko, Luda, additional, Rashid, Naim U., additional, Zhong, Sheng, additional, Smith, Shad, additional, Rhodes, Jesse, additional, Medvedev, Alex, additional, Makarov, Sergei, additional, Maixner, William, additional, and Nackley, Andrea G., additional

Published
2011
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239. Potential Autonomic Risk Factors for Chronic TMD: Descriptive Data and Empirically Identified Domains from the OPPERA Case-Control Study

Author

Maixner, William, primary, Greenspan, Joel D., additional, Dubner, Ronald, additional, Bair, Eric, additional, Mulkey, Flora, additional, Miller, Vanessa, additional, Knott, Charles, additional, Slade, Gary D., additional, Ohrbach, Richard, additional, Diatchenko, Luda, additional, and Fillingim, Roger B., additional

Published
2011
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240. Study Methods, Recruitment, Sociodemographic Findings, and Demographic Representativeness in the OPPERA Study

Author

Slade, Gary D., primary, Bair, Eric, additional, By, Kunthel, additional, Mulkey, Flora, additional, Baraian, Cristina, additional, Rothwell, Rebecca, additional, Reynolds, Maria, additional, Miller, Vanessa, additional, Gonzalez, Yoly, additional, Gordon, Sharon, additional, Ribeiro-Dasilva, Margarete, additional, Lim, Pei Feng, additional, Greenspan, Joel D., additional, Dubner, Ron, additional, Fillingim, Roger B., additional, Diatchenko, Luda, additional, Maixner, William, additional, Dampier, Dawn, additional, Knott, Charles, additional, and Ohrbach, Richard, additional

Published
2011
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241. Potential Genetic Risk Factors for Chronic TMD: Genetic Associations from the OPPERA Case Control Study

Author

Smith, Shad B., primary, Maixner, Dylan W., additional, Greenspan, Joel D., additional, Dubner, Ronald, additional, Fillingim, Roger B., additional, Ohrbach, Richard, additional, Knott, Charles, additional, Slade, Gary D., additional, Bair, Eric, additional, Gibson, Dustin G., additional, Zaykin, Dmitri V., additional, Weir, Bruce S., additional, Maixner, William, additional, and Diatchenko, Luda, additional

Published
2011
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246. Catechol O-Methyltransferase Haplotype Predicts Immediate Musculoskeletal Neck Pain and Psychological Symptoms After Motor Vehicle Collision

Author

McLean, Samuel A., primary, Diatchenko, Luda, additional, Lee, Young M., additional, Swor, Robert A., additional, Domeier, Robert M., additional, Jones, Jeffrey S., additional, Jones, Christopher W., additional, Reed, Caroline, additional, Harris, Richard E., additional, Maixner, William, additional, Clauw, Daniel J., additional, and Liberzon, Israel, additional

Published
2011
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247. A Genome-wide Drosophila Screen for Heat Nociception Identifies α2δ3 as an Evolutionarily Conserved Pain Gene

Author

Neely, G. Gregory, primary, Hess, Andreas, additional, Costigan, Michael, additional, Keene, Alex C., additional, Goulas, Spyros, additional, Langeslag, Michiel, additional, Griffin, Robert S., additional, Belfer, Inna, additional, Dai, Feng, additional, Smith, Shad B., additional, Diatchenko, Luda, additional, Gupta, Vaijayanti, additional, Xia, Cui-ping, additional, Amann, Sabina, additional, Kreitz, Silke, additional, Heindl-Erdmann, Cornelia, additional, Wolz, Susanne, additional, Ly, Cindy V., additional, Arora, Suchir, additional, Sarangi, Rinku, additional, Dan, Debasis, additional, Novatchkova, Maria, additional, Rosenzweig, Mark, additional, Gibson, Dustin G., additional, Truong, Darwin, additional, Schramek, Daniel, additional, Zoranovic, Tamara, additional, Cronin, Shane J.F., additional, Angjeli, Belinda, additional, Brune, Kay, additional, Dietzl, Georg, additional, Maixner, William, additional, Meixner, Arabella, additional, Thomas, Winston, additional, Pospisilik, J. Andrew, additional, Alenius, Mattias, additional, Kress, Michaela, additional, Subramaniam, Sai, additional, Garrity, Paul A., additional, Bellen, Hugo J., additional, Woolf, Clifford J., additional, and Penninger, Josef M., additional

Published
2010
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249. Pain perception is altered by a nucleotide polymorphism in SCN9A

Author

Reimann, Frank, primary, Cox, James J., additional, Belfer, Inna, additional, Diatchenko, Luda, additional, Zaykin, Dmitri V., additional, McHale, Duncan P., additional, Drenth, Joost P. H., additional, Dai, Feng, additional, Wheeler, Jerry, additional, Sanders, Frances, additional, Wood, Linda, additional, Wu, Tian-Xia, additional, Karppinen, Jaro, additional, Nikolajsen, Lone, additional, Männikkö, Minna, additional, Max, Mitchell B., additional, Kiselycznyk, Carly, additional, Poddar, Minakshi, additional, te Morsche, Rene H.M., additional, Smith, Shad, additional, Gibson, Dustin, additional, Kelempisioti, Anthi, additional, Maixner, William, additional, Gribble, Fiona M., additional, and Woods, C. Geoffrey, additional

Published
2010
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