67,431 results on '"Dhar, A"'
Search Results
202. Scopoletin alleviates high glucose-induced toxicity in human renal proximal tubular cells via inhibition of oxidative damage, epithelial-mesenchymal transition, and fibrogenesis
- Author
-
Kundu, Sourav, Ghosh, Sitara, and Sahu, Bidya Dhar
- Published
- 2024
- Full Text
- View/download PDF
203. Bose-Einstein condensation of non-ground-state caesium atoms
- Author
-
Horvath, Milena, Dhar, Sudipta, Das, Arpita, Frye, Matthew D., Guo, Yanliang, Hutson, Jeremy M., Landini, Manuele, and Nägerl, Hanns-Christoph
- Published
- 2024
- Full Text
- View/download PDF
204. A comparative study in left-sided breast cancer treated with moderate deep inspiratory breath hold versus free breathing
- Author
-
Muraleedharan, Anupam, Barik, Sandip Kumar, Das, Deepak Kumar, Das Majumdar, Saroj Kumar, Mahapatra, Bikash Ranjan, Barik, Bijay Kumar, Ramasubbu, Mathan Kumar, M., Nehla Haroon K., U., Poornima Devi, Ahmed, Sk Soel, Mukherjee, Priyanka, Pattanaik, Ashutosh, Badajena, Avinash, Mishra, Minakshi, Kanungo, Satyabrata, Dhar, Sovan Sarang, and Parida, Dillip Kumar
- Published
- 2024
- Full Text
- View/download PDF
205. Integrated image and location analysis for wound classification: a deep learning approach
- Author
-
Patel, Yash, Shah, Tirth, Dhar, Mrinal Kanti, Zhang, Taiyu, Niezgoda, Jeffrey, Gopalakrishnan, Sandeep, and Yu, Zeyun
- Published
- 2024
- Full Text
- View/download PDF
206. Hymenopteran parasitoid complex and fall armyworm: a case study in eastern India
- Author
-
Pal, Subhajit, Bhattacharya, Swarnali, Dhar, Tapamay, Gupta, Ankita, Ghosh, Arunava, Debnath, Sandip, Gangavarapu, Nikhitha, Pati, Prajna, Chaudhuri, Nilanjana, Chatterjee, Hirak, Senapati, Sabita Kumar, Bhattacharya, Prateek Madhab, Gathala, Mahesh Kumar, and Laing, Alison M.
- Published
- 2024
- Full Text
- View/download PDF
207. Exploration of underlap induced high-k spacer with gate stack on strain channel cylindrical nanowire FET for enriched performance
- Author
-
Barik, Rasmita, Dhar, Rudra Sankar, and Hussein, Mousa I.
- Published
- 2024
- Full Text
- View/download PDF
208. Soil carbon sequestration potential of different land use systems: evidence from sub-humid southern plains and Aravalli hills of Rajasthan, India
- Author
-
Meena, Ram Bhawan, Meena, Subhash Chander, Rathore, Avinash Chandra, Meena, Dinesh Chand, Meena, Roshan Lal, Alam, Nurnabi Meherul, Sharma, Kamal Kishor, Kumar, Prabhat, Meena, Gopal Lal, and Meena, Murli Dhar
- Published
- 2024
- Full Text
- View/download PDF
209. Valorization of oil refinery by-products: production of sophorolipids utilizing fatty acid distillates and their potential antibacterial, anti-biofilm, and antifungal activities
- Author
-
Pal, Srija, Chatterjee, Niloy, Sinha Roy, Sagnik, Chattopadhyay, Brajadulal, Acharya, Krishnendu, Datta, Sriparna, and Dhar, Pubali
- Published
- 2024
- Full Text
- View/download PDF
210. A hybrid approach for Bengali sentence validation
- Author
-
Sikder, Juel, Chakraborty, Prosenjit, Das, Utpol Kanti, and Dhar, Krity
- Published
- 2024
- Full Text
- View/download PDF
211. Sensitivity Analysis of Biosensor-Based SiGe Source Dual Gate Tunnel FET Having Negative Capacitance
- Author
-
Dipshika Das, Rudra Sankar Dhar, Pradip Kumar Ghosh, Yash Sharma, and Amit Banerjee
- Subjects
Biosensor ,charge plasma ,dielectric modulation ,sensitivity ,heterojunction ,dual gate ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 - Abstract
This work proposes a unique design of charge plasma based junctionless SiGe source TFET with dual cavity and ferroelectric gate dielectric. The biosensor works on the principle of dielectric modulation for label-free detection, where the cavity lies under the source and gate metal just around the tunneling junction of the dual gate TFET. Nanocavity above the source and gate regions act as reservoir of biomolecules (to be detected) around the tunneling junction, letting the drain current modulate. Cavity dimensions and its placement have been optimized to achieve better current sensitivity. Dual gate architecture with laterally split dielectric is used to overcome the short channel impact and to enhance the current ratio. The biosensor can recognize neutral, positive, and negative charges with the highest drain current sensitivity and ION/IOFF ratio for biomolecule gelatin. It engages the principle of negative capacitance for better subthreshold swing and ON current for identification of biomolecules such as gelatin (k = 12), keratin (k = 8), streptavidin (k = 2.1), bacteriophage T7 (k = 6.3), and APTES (k = 3.57) at low voltage biasing. Finally, RF analyzes are carried out to explore the benefits of using negative capacitance where the biosensor acts as an intrinsic voltage amplifier exhibiting superior gain-bandwidth product (GBP) and cut-off frequency (fT), indicating its potential for high-speed operation and real-time sensing applications. The research yields repeatable outcomes for several calculated analyses.
- Published
- 2025
- Full Text
- View/download PDF
212. Corneal densitometry changes post-CXL for keratoconus: Comparative evaluation of epithelium-off, contact lens-assisted, and transepithelial techniques
- Author
-
Barkha Gupta, Chintan Malhotra, Supriya Dhar, Khushdeep Abhyapal, Arun K. Jain, and Amit Gupta
- Subjects
contact lens-assisted corneal cross-linking ,corneal densitometry ,“epithelium-off” corneal cross-linking ,keratoconus ,transepithelial corneal cross-linking ,Ophthalmology ,RE1-994 - Abstract
Purpose: To evaluate changes in corneal backscattering after collagen cross-linking (CXL) for progressive keratoconus and compare its course with different techniques – standard epithelium-off CXL (SCXL), contact lens-assisted CXL (CACXL), and transepithelial CXL (TECXL). Setting: Advanced Eye Center, Post Graduate Institute of Medical Education and Research, Chandigarh, India. Design: Retrospective comparative study. Methods: Ninety-four eyes (SCXL: 47, CACXL: 30, and TECXL: 17) were compared. Corneal haze was quantified using Scheimpflug tomography, pre- and post-CXL at 1, 3, 6, and 12 months. Results: The baseline mean density score of the central anterior stromal layer was 16.14 ± 7.07, 15.85 ± 7.89 and 15.89 ± 7.21 in SCXL, CACXL, and TECXL groups, respectively (P 0.93). After SCXL, the score increased to 28.83 and 31.34 at 1 and 3 months, respectively (both P < 0.001) and dropped at 6 months (28.66, P < 0.001) and 12 months (23.72, P 0.003). Post-CACXL, the mean densitometry peaked at 3 months (20.35, P 0.14) and returned toward baseline at 6 months (18.82, P 0.15). After TECXL, it increased slightly at 1 month (18.47, P 0.17), decreased at 3 months (14.88, P 0.7), and plateaued over 1 year. No correlation with visual acuity was seen. Conclusion: Corneal haze increased significantly after SCXL, peaking at 3 months, declining over 6–12 months, and returning to baseline at 12 months. In contrast, post-TECXL and -CACXL, there was an insignificant increase in anterior corneal haze, which returned to baseline within 3–6 months.
- Published
- 2025
- Full Text
- View/download PDF
213. Slope stability and surface displacement analysis of the Kuther Landslide in the Dehar Watershed, Himachal Himalaya, Northern India
- Author
-
Arun Kumar, Shashi Kant Rai, Imran Khan, Manthena Prashanth, Sunil Dhar, and Omkar Verma
- Subjects
Landslides ,Slope stability ,Surface displacement ,Natural hazards ,Dehar watershed ,Himachal Himalaya ,Geology ,QE1-996.5 ,Geophysics. Cosmic physics ,QC801-809 - Abstract
Abstract The road network in the Himalayan terrain is vital for India's socio-economic development and national security, yet the complexities of topography, geological structures, diverse lithology, and neotectonics make planning and maintaining these routes a challenging task. Population growth and expanding road construction have caused slope destabilization, mass wasting, and movement across the Himalayan terrain. Field-based slope stability assessments are essential for slope mass characterization and slope stabilization, helping planners predict and select suitable construction strategies for roads and other infrastructure. This study presents a comprehensive slope stability and displacement analysis of the Kuther landslide, situated along the Jawali to Kuther road in the Dehar Watershed, Kangra District, Himachal Pradesh. An integrated approach was used, combining surface displacement monitoring with the COSI-Corr technique and slope stability assessments through methods such as rock mass rating, kinematic analysis, slope mass rating, and continuous slope mass rating. Findings indicate that the slope is highly susceptible to planar failure, with some instances of wedge failure. The rock mass ranges from class III to IV, indicating conditions from partially stable to stable, while displacement analysis reveals the slope is creeping at an average rate of 4 mm/year. This study highlights the critical need for comprehensive slope stability and displacement analyses to ensure the safety of vulnerable areas and their communities.
- Published
- 2025
- Full Text
- View/download PDF
214. Facilitating automated fact-checking: a machine learning based weighted ensemble technique for claim detection
- Author
-
Md. Rashadur Rahman, Rezaul Karim, Mohammad Shamsul Arefin, Pranab Kumar Dhar, Gahangir Hossain, and Tetsuya Shimamura
- Subjects
Check-worthiness ,Fact-checking ,Claim detection ,Nlp for low resource language ,Computational journalism ,Science (General) ,Q1-390 - Abstract
Abstract The rapid digitization of media, driven by technological advancements, has accelerated the spread of information through online platforms. This has heightened the need for robust fact-checking mechanisms to counter misinformation. The prevalence of misinformation necessitates the development of automated claim detection systems to support efficient automated or semi-automated fact-checking processes. Existing claim detection systems predominantly focus on the English language, with limited resources available for other regional languages like Bangla. This paper proposes a novel ensemble machine learning framework for the effective detection of claims in a low-resource language like Bangla, a critical initial step in the automated fact-checking process. The proposed weighted ensemble technique combines Support Vector Machines, Bernoulli Naive Bayes, and Decision Trees as base classifiers to effectively detect claims. An annotated text dataset comprising 5010 sentences sourced from various online platforms, including several online fact-checking sites, was developed. To determine the optimal model and feature representation for claim detection, various machine learning algorithms were evaluated using BoW, TF-IDF, Word2Vec, and FastText features. The efficacy of ensemble models was examined by investigating both averaging and weighting strategies. Evaluation metrics showcased that the proposed weighted ensemble approach outperformed all baseline models, achieving a maximum F1 score of 0.87. To the best of our knowledge, this study is the first and only approach to claim detection in the Bangla language, with the potential for extension to other resource-constrained languages. Our work aspires to serve as a crucial tool in the fight against misinformation by advancing the accuracy and transparency of information.
- Published
- 2025
- Full Text
- View/download PDF
215. A 7-point evidence-based care discharge protocol for patients hospitalized for exacerbation of COPD: consensus strategy and expert recommendation
- Author
-
Sundeep Salvi, Deesha Ghorpade, Sanjeev Nair, Lancelot Pinto, Ashok K. Singh, K. Venugopal, Raja Dhar, Deepak Talwar, Parvaiz Koul, and Pralhad Prabhudesai
- Subjects
Diseases of the respiratory system ,RC705-779 - Abstract
Abstract Acute exacerbations of COPD (ECOPD) are an important event in the life of a COPD patient as it causes significant deterioration of physical, mental, and social health, hastens disease progression, increases the risk of dying and causes a huge economic loss. Preventing ECOPD is therefore one of the most important goals in the management of COPD. Before the patient is discharged after hospitalization for ECOPD, it is crucial to offer an evidence-based care bundle protocol that will help minimize the future risk of readmissions and death. To develop the content of this quality care bundle, an Expert Working Group was formed, which performed a systematic review of literature, brainstormed, and debated on key clinical issues before arriving at a consensus strategy that could help physicians achieve this goal. A 7-point consensus strategy was prepared, which included: (1) enhancing awareness and seriousness of ECOPD, (2) identifying patients at risk for future exacerbations, (3) optimizing pharmacologic treatment of COPD, (4) identifying and treating comorbidities, (5) preventing bacterial and viral infections, (6) pulmonary rehabilitation, and (7) palliative care. Physicians may find this 7-point care bundle useful to minimize the risk of future exacerbations and reduce morbidity and mortality.
- Published
- 2024
- Full Text
- View/download PDF
216. Ecytonucleospora hepatopenaei (EHP) disease prevalence and mortality in Litopenaeus vannamei: a comparative study from Eastern India shrimp farms
- Author
-
Vikash Kumar, Basanta Kumar Das, Souvik Dhar, Kampan Bisai, Gde Sasmita Julyantoro Pande, Xiaoting Zheng, Satya Narayan Parida, Anupam Adhikari, and Asim Kumar Jana
- Subjects
EHP ,Litopenaeus vannamei ,Morality ,Gene expression ,Gut bacteria ,Microbiology ,QR1-502 - Abstract
Abstract Ecytonucleospora hepatopenaei (EHP), a microsporidian parasite first named and characterized from the Penaeus monodon (black or giant tiger shrimp), causes growth retardation and poses a significant threat to shrimp farming. We observed shrimp farms associated with disease conditions during our fish disease surveillance and health management program in West Bengal, India. Shrimp exhibited growth retardation and increased size variability, particularly in advanced stages, exhibiting soft shells, lethargy, reduced feeding and empty midguts. Floating white feces were observed on the surface of the pond water. Suspecting a microbial infection, the shrimp samples were collected and aseptically brought to the ICAR-CIFRI laboratory for molecular confirmation. A nested PCR was used to screen shrimp tissue, feces, feed and environmental samples for the possible presence of hepatopancreatic microsporidiosis caused by Ecytonucleospora hepatopenaei. The results confirmed that the shrimp samples were positive for EHP. Histopathological investigation revealed mature spores in the HP tubule lumen and epithelial cells along with necrotic tubule in the symptomatic group. Further, the transcription analysis revealed that ProPO, Hsp70 and α2-macroglobulin genes were significantly upregulated, while decreased expression of LGBP, PXN and Integrin ß was observed in shrimp infected with Hepatopancreatic microsporidiosis. Furthermore, compared with the healthy group, significant intestinal bacteria changes were observed in the EHP-infected group. The in vivo survival assay, using crustacean animal model Artemia franciscana, suggests that symptomatic shrimp gut samples harbour pathogenic Vibrio parahaemolyticus, V. harveyi and V. campbellii. These results significantly advance our understanding of the molecular and ecological aspects of EHP pathobiology.
- Published
- 2024
- Full Text
- View/download PDF
217. Quantitative kinetic rules for plastic strain-induced α - ω phase transformation in Zr under high pressure
- Author
-
Achyut Dhar, Valery I. Levitas, K. K. Pandey, Changyong Park, Maddury Somayazulu, and Nenad Velisavljevic
- Subjects
Materials of engineering and construction. Mechanics of materials ,TA401-492 ,Computer software ,QA76.75-76.765 - Abstract
Abstract Plastic strain-induced phase transformations (PTs) and chemical reactions under high pressure are broadly spread in modern technologies, friction and wear, geophysics, and astrogeology. However, because of very heterogeneous fields of plastic strain $${{\boldsymbol{E}}}^{p}$$ E p and stress σ tensors and volume fraction c of phases in a sample compressed in a diamond anvil cell (DAC) and impossibility of measurements of σ and $${{\boldsymbol{E}}}^{p}$$ E p , there are no strict kinetic equations for them. Here, we develop a kinetic model, finite element method (FEM) approach, and combined FEM-experimental approaches to determine all fields in strongly plastically predeformed Zr compressed in DAC, and specific kinetic equation for α-ω PT consistent with experimental data for the entire sample. Since all fields in the sample are very heterogeneous, data are obtained for numerous complex 7D paths in the space of 3 components of the plastic strain tensor and 4 components of the stress tensor. Kinetic equation depends on accumulated plastic strain (instead of time) and pressure and is independent of plastic strain and deviatoric stress tensors, i.e., it can be applied for various above processes. Our results initiate kinetic studies of strain-induced PTs and provide efforts toward more comprehensive understanding of material behavior in extreme conditions.
- Published
- 2024
- Full Text
- View/download PDF
218. CLOCK gene 3’UTR and exon 9 polymorphisms show a strong association with essential hypertension in a North Indian population
- Author
-
Shreya Sopori, Kavinay Kavinay, Sonali Bhan, Shreya Saxena, Medha Medha, Rakesh Kumar, Arti Dhar, and Audesh Bhat
- Subjects
Essential hypertension ,Circadian rhythm ,Case‒control study ,Genetic association ,SNPs ,CLOCK ,Internal medicine ,RC31-1245 ,Genetics ,QH426-470 - Abstract
Abstract Background Hypertension (HTN) is a medical condition characterized by persistent systolic and diastolic blood pressures of ≥ 140 mmHg and ≥ 90 mmHg, respectively. With more than 1200 million adult patients aged 30–79 years worldwide according to the latest WHO data, HTN is a major health risk factor; more importantly, 46% of patients are unaware of this condition. Essential hypertension (EH), also known as primary hypertension, is the predominant subtype and has a complex etiology that involves both genetic and non-genetic factors. Majority of living organisms are influenced by the light and dark cycle of a day and respond to these changes through an intricate clock referred to as the “biological clock” or “circadian rhythm”. The connection between circadian rhythm and blood pressure is well established, with many studies supporting the role of circadian rhythm gene mutation(s)/polymorphism(s) in EH. To date, no such data are available from any Indian population. Methods This case‒control study was conducted on 405 EH patients and 505 healthy controls belonging to the Jammu region of North India after an informed consent was obtained from the participants. A total of three single nucleotide variants, two in the CLOCK gene (rs1801260 and rs34789226) and one in the BMAL1/ARNTL gene (rs6486121), were selected for genotyping. Genotyping was performed via the RFLP technique, and the applicable statistical analyses were performed via the SPSS and SNPStats programs. Results Logistic regression analysis revealed a statistically significant association of both CLOCK gene variants rs1801260 (T > C 3’UTR) and rs34789226 (C > T Exon 9) and a nonsignificant association of the BMAL1/ARNTL intronic variant rs6486121 (C > T) with EH. The 3’UTR variant showed a statistically significant association under the codominant (p
- Published
- 2024
- Full Text
- View/download PDF
219. Preparation and Characterization of New Biodegradable Packaging Materials Based on Gelatin Extracted from Tenualosa ilisha Fish Scales with Cellulose Nanocrystals
- Author
-
Md. Abdul Mottalib, Md. Hasan Islam, Mohon Chandra Dhar, Kawsar Akhtar, and Md. Abdul Goni
- Subjects
Chemistry ,QD1-999 - Published
- 2024
- Full Text
- View/download PDF
220. EXPLORING PREVALENCE, ANTIMICROBIAL SUSCEPTIBILITY, VIRULENCE PROFILES, AND MULTIDRUG RESISTANCE IN STAPHYLOCOCCUS AUREUS ISOLATES FROM RESPIRATORY DISEASE-AFFECTED SHEEP AND GOATS REARED BY THE MIGRATORY COMMUNITIES OF LOWER HIMALAYAS
- Author
-
Sunaina Thakur, Subhash Verma, Shivani Barsain, Prasenjit Dhar, Geetanjali Singh, and Rajesh Chahota
- Subjects
staphylococcus aureus ,sheep ,goat ,himalayas ,mdr ,mar index ,amr genes ,virulence genes ,antibiotic susceptibility ,Veterinary medicine ,SF600-1100 - Abstract
Staphylococcus aureus is a significant bacterium that causes substantial economic losses in the livestock sector and poses life-threatening risks to both humans and animals. This study aimed to explore the prevalence, susceptibility to antimicrobials, and profiles of virulence and antimicrobial resistance (AMR) genes in S. aureus isolated from nasal swabs and lung tissues of sheep and goats exhibiting symptoms of respiratory disease. A total of 194 samples were examined, resulting in the isolation and confirmation of S. aureus in 65 samples, indicating an overall prevalence of 33.5%. These isolates were further subjected to an AMR assay. Among the representative isolates (37), sensitivity was observed to chloramphenicol and ceftriaxone. Conversely, penicillin showed the lowest efficacy, with 83.8% of isolates demonstrating resistance, followed closely by amoxiclav, which exhibited resistance in 75.7% of isolates. Close to threequarters of isolates carried at least one AMR gene. Virulence genes were identified in 67.6% of S. aureus isolates, with coa and lukpv detected in 37.8% and arcA in 32.4% of isolates. Additionally, mecA and vatC were present in 54.05%, vatB in 43.25% and aphD in 18.91% of S. aureus isolates. A substantial 91.9% of isolates exhibited multidrug resistance, and MAR indices exceeding 0.2 were recorded in 86.5% of S. aureus isolates, indicating a high public health risk. These findings underscore the importance of prioritizing infections caused by S. aureus, necessitating heightened attention from both veterinarians and healthcare workers in migratory communities. Furthermore, the regulated and judicious use of antimicrobials is crucial to mitigate the risks associated with antimicrobial resistance in these settings.
- Published
- 2024
- Full Text
- View/download PDF
221. Experimental and numerical investigations on tensile properties of carbon fibre-reinforced plastic and self-reinforced polypropylene composites
- Author
-
Ma Quanjin, Sahu Santosh Kumar, Badgayan Nitesh Dhar, and Rejab Mohd Ruzaimi Mat
- Subjects
tensile properties ,carbon fibre-reinforced plastic ,self-reinforced polypropylene ,Mechanical engineering and machinery ,TJ1-1570 - Abstract
This article aims to investigate the tensile properties of carbon fibre-reinforced plastic (CFRP) and self-reinforced polypropylene (SRPP) composites used in both experimental and numerical investigations. The experimental study evaluated the tensile strength, tensile strain, and modulus of CFRP and SRPP composite laminates under tensile loading. Finite element modelling was employed to predict and validate the tensile properties of these composites. CFRP and SRPP laminates were manufactured using the hot compression technique and stacked through the hand lay-up technique. The results revealed that CFRP with a unidirectional pattern provided a higher tensile strength (1,162 MPa) than the twill pattern (288 MPa) with nominal strain values of 0.017 and 0.013 in the CFRP-based system, respectively. It was observed that the results of CFRP and SRPP composites provided a good agreement between experimental and numerical investigations. Moreover, the failure behaviour of CFRP and SRPP laminates was evaluated and compared with experimental and numerical results. Furthermore, practical applications of CFRP and SRPP composites for lightweight parts are presented.
- Published
- 2024
- Full Text
- View/download PDF
222. Machine Learning-based Disease Classification in Tomato (Solanum lycopersicum) Plants
- Author
-
Md Towfiqur Rahman, Sudipto Dhar Dipto, Israt Jahan June, Abdul Momin, and Muhammad Rashed Al Mamun
- Subjects
detection ,image processing ,machine learning ,plant diseases ,tomato ,deteksi ,pembelajaran mesin ,pemrosesan gambar ,penyakit tanaman ,tomat ,Agriculture - Abstract
In Bangladesh, tomato cultivation faces significant challenges due to its susceptibility to various microorganisms, parasites, and bacterial infections. Typically, the early symptoms of these diseases first appear in roots and leaves, complicating timely detection. This study addresses the challenge of timely and accurate detection of diseases in tomato plants, crucial for effective plant protection management. Conventional manual inspection methods are time-consuming and subjective, resulting in delays in implementing necessary protection measures. Therefore, an image processing technique and machine learning algorithms were used for rapid and robust detection of diseases in tomato plant leaves, aiming to streamline the detection process for chemical application responses. A dataset containing 250 images of tomato plant leaves were captured under varying light intensities, eye-level angles, and distances. Image augmentation techniques were applied to increase the dataset, resulting in a total of 529 images. These images were converted to LAB color images and then OTSU algorithm was used to segment leaf images and estimate the percentage of affected diseased areas. Various textural features were also extracted from segmented leaf images to create a training dataset. Machine learning algorithms, including Support Vector Machines (SVM), K-Nearest Neighbors (KNN), and decision trees, were trained and evaluated using this dataset to classify images as healthy or diseased. The Quadratic SVM algorithm provided the highest test accuracy of 97.7% for the dataset. This nondestructive processing holds immense promise for improving disease detection efficiency and reducing losses in tomato production, both locally in Bangladesh and globally.
- Published
- 2024
- Full Text
- View/download PDF
223. Population-based Research in AYUSH: Lessons from Study among Particularly Vulnerable Tribal Groups to Determine Burden of Sickle Cell Disorders
- Author
-
Nisanth K. M. Nambison, Abhishek Dhar Dwivedi, Sanjeev Kumar, Garima Goel, Pankaj Prasad, Gyanendra Singh, S. Rajasubramaniam, and Ravindra Kumar
- Subjects
ayush ,baiga ,bhariya ,complementary and alternative medicine ,hemoglobinopathy ,mixed methods study ,scd ,solubility test ,survey ,tribals ,tribes ,Medicine - Abstract
Background: Population-based research (PBR) plays a critical role in generating externally valid evidence and engaging local communities in health interventions. However, there is a lack of examples in the field of homeopathy. This study describes the transformation of a Homoeopathy Medical College and Hospital to initiate and sustain PBR. The focus was on Particularly Vulnerable Tribal Groups (PVTGs) of India, with a specific emphasis on sickle cell disorders (SCD), a significant health concern among tribal populations in Madhya Pradesh (MP). Aims and Objectives: The study aimed to estimate the burden of SCD among PVTGs in MP and evaluate the effectiveness of homeopathy as an adjuvant therapy. Materials and Methods: A sequential explanatory mixed methods design was used, incorporating document analysis, a structured literature review on PubMed, and a search of homeopathy journals and conference abstracts. A community-based cross-sectional survey was conducted using probability proportional to size (PPS) sampling in four districts of MP. Blood samples were collected for SCD diagnosis, and ethical clearance was obtained from the Government Homoeopathic Medical College and Hospital, Bhopal. Results: The study surveyed 27,892 individuals (mean age 27.71 ± 18.11 years) from the Baiga and Bhariya PVTGs across 346 villages. Out of these, 23,320 participants were deemed eligible for screening. Sickle cell solubility tests revealed that 9.4% (n = 2195) of participants were suspected to have SCD. A comprehensive module and Standard Operating Procedure (SOP) on PBR in homeopathy was developed for future researchers. Conclusion: This study provides a blueprint for implementing PBR in homeopathy, particularly with vulnerable populations. The use of mixed methods research in PBR, especially for assessing homeopathy’s role in managing SCD, is valuable for extending research in underrepresented populations.
- Published
- 2024
- Full Text
- View/download PDF
224. Sex-related Differences in Insulin Resistance in the Geriatric Population
- Author
-
Ravi Kant, Dipesh Jha, Gaurav Karna, Balachandra Routhu, and Minakshi Dhar
- Subjects
diabetes ,geriatric ,homeostasis model assessment ,insulin resistance ,postmenopause ,Geriatrics ,RC952-954.6 - Abstract
Background: Diabetes mellitus significantly impacts long-term cardiovascular disease, increasing elderly mortality and morbidity. Half of elderly diabetics are asymptomatic, with vague symptoms. Insulin resistance (IR) and pancreatic beta-cell dysfunction are central to diabetes pathophysiology. Gender differences in IR and beta-cell function are increasingly recognized in diabetes research. Methods: In 18-month observational cross-sectional study focusing on elderly patients (60+) done at tertiary hospital in North India included 32 diabetic and 32 healthy controls. Fasting blood sample of eligible subjects were sent for hemogram, hemoglobin A1c (HBA1c), blood glucose, and insulin. IR and beta-cell function were calculated using the homeostasis model assessment (HOMA) model and analyzed using SPSS, with P < 0.05. Results: The mean age of participants was 67.77 years and the average duration of having diabetes was 5.11 years. Median HOMA IR was significantly higher in cases compared to controls (4.23 vs 0.89, P < 0.05), while HOMA β was comparable. HOMA IR decreased with longer diabetes duration, with a more rapid decline in female subjects compared to males. Subgroup analysis showed IR increased with age and was higher in females. Conclusion: Our research highlights gender-based differences in IR in the geriatric age group. Elderly women had higher IR compared to men. These findings are significant in understanding gender-specific metabolic differences and tailoring interventions. Further research with a larger sample size is warranted to corroborate these findings. Clinical Implication: This study addresses the gap in research on IR and beta-cell function in the elderly, particularly in India. This research can be compared with past studies on other age groups, aiding in the development of tailored diabetes treatments and improving therapeutic strategies for the elderly.
- Published
- 2024
- Full Text
- View/download PDF
225. Polypharmacy in an Older Female: Thoughtful Deprescribing
- Author
-
Sudeep Mathew George, Vasu, Kritartha Kashyap, and Minakshi Dhar
- Subjects
deprescribing ,polypharmacy ,prescription cascade ,shared decision-making ,Geriatrics ,RC952-954.6 - Abstract
The magnitude of polypharmacy is on the rise as the global population faces a demographic shift with a larger proportion of older people, along with a marked increase in the prevalence of multimorbidity. An 85-year-old woman with diabetes mellitus, systemic hypertension, rheumatoid arthritis, chronic depression, parkinsonism, and dementia presented with inappropriate polypharmacy, taking 32 medications. Comprehensive medication reconciliation was performed using the Discuss, Review, Use tools, Geriatric medicine approach, and Stop medication guide, assessing appropriateness based on Beers Criteria. Goals of care were established through shared decision-making, focusing on reducing her pill burden and relaxing treatment targets for blood pressure and glycated hemoglobin. The patient was ultimately prescribed 13 medications. This case highlights the importance of tailored, patient-centered approaches in managing polypharmacy and chronic conditions in older adults to improve overall health outcomes.
- Published
- 2024
- Full Text
- View/download PDF
226. Pathological effects and immune modulation in host during Tilapia Parvovirus (TiPV) outbreak in cage and wetland Tilapia farms
- Author
-
Basanta Kumar Das, Vikash Kumar, Suvra Roy, Ramesh Chandra Malick, Kampan Bisai, Asim Kumar Jana, and Souvik Dhar
- Subjects
Disease outbreak ,Tilapia ,Tilapia Parvovirus ,Pathological condition ,Immune response ,Medicine ,Science - Abstract
Abstract Viral diseases arising in farmed fish are an ongoing challenge to the aquaculture industry, causing severe mortality and economic losses. Recently, there has been a spike in the incidence of a viral disease caused by Tilapia Parvovirus (TiPV) inflicts irreparable damage, and large-scale fish kills in the farmed tilapia species. We investigated a case of disease outbreak and severe mortality in cage and wetland farms of tilapia in West Bengal and Odisha, India. The symptomatic fish showed clinical signs, including hemorrhage, discoloration, ulcer, and redness in the body surfaces. Further analysis revealed that Tilapia Parvovirus was associated (validated by PCR, phylogenetic analysis, and cell line assay) with the infection and mortality of tilapia. The virus was detected in gill, heart, spleen, liver, and kidney samples collected from apparently healthy (asymptomatic) and symptomatic tilapia samples from cage and wetland farms. At the same time, negative results were found in the brain and skin tissue samples. The histological analysis revealed that TiPV induces severe damage invariably in almost all studied tissue, including the liver, kidney, spleen, gill, heart, and brain of tilapia samples. The viral quantification analysis showed that the viral genome was higher in the liver, spleen, and heart than in the tilapia samples’ gill, kidney, or brain tissue. Furthermore, the study indicated that TiPV infection has a significant effect on the health of tilapia. The tilapia exhibited an immune reactivity toward TiPV infection (upregulation of chemokine receptors, CRs and interleukin 1β, IL-1β), the majority of the studied immune genes (interleukin 8, IL-8; Toll-like receptors 7, TLR7; tumour necrosis factor α, TNF-α; major histocompatibility complex II, MHC II and nuclear factor kappa B, NF-kB) were significantly downregulated in the kidney, spleen and liver tissue samples of symptomatic tilapia. Further, the in vivo challenge assay confirms that the isolated TiPV is a novel parvovirus pathogen that causes massive mortality in tilapia. The lessons learned from the first cellular and molecular description associated with TiPV epidemiology from wetland and cage farms of tilapia could be critical to developing the current state of the tilapia farming industry. Additionally, a holistic approach is needed to develop management measures to control the virulence and risk factors of TiPV.
- Published
- 2024
- Full Text
- View/download PDF
227. Prognostic role of Androgen Receptor splice variant 7 (AR-V7) in the pathogenesis of breast cancer
- Author
-
Tryambak Pratap Srivastava, Swati Ajmeriya, Isha Goel, Joyeeta Talukdar, Anurag Srivastava, Rajinder Parshad, S.V.S. Deo, Sandeep R. Mathur, Ajay Gogia, Avdhesh Rai, Ruby Dhar, and Subhradip Karmakar
- Subjects
Breast cancer ,Androgen receptor ,Splice variant ,AR-V7 ,Biomarker ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background The Androgen Receptor (AR) has emerged as an endocrine therapy target in Breast Cancer, exhibiting up to 80% expression in clinical cases. AR-V7, a constitutively activated splice variant of AR with a truncated ligand-binding domain (LBD), demonstrates ligand-independent transcriptional activity and resistance to nonsteroidal antiandrogens like Bicalutamide or Enzalutamide, targeting the LBD. In metastatic prostate cancer, elevated AR-V7 levels lead to therapeutic resistance and increased metastasis. Methods In this study, we evaluated the expression of AR and AR-V7 in cell lines and a cohort of 89 patients undergoing surgical intervention for treatment-naïve breast cancer. Further clinicopathological correlations and survival analysis were performed to evaluate the relationship between the AR and AR-V7 expression and clinical outcomes. Results AR-V7/AR-FL ratio was elevated in the TNBC cell line and downregulation of AR-FL upon AR antagonists’ treatment led to a compensatory increase in AR-V7. Clinical samples showed significantly elevated expression of AR and AR-V7 in tumors compared to control cases. Further clinicopathological correlation revealed aggressive clinical traits, higher pathological grades, and poor survival with AR-V7 expression. Conclusions Our study unravels AR-V7 as a marker for poor clinical outcomes, predicting breast cancer aggressiveness, and encourages consideration of AR-V7 as a probable target for therapeutic intervention.
- Published
- 2024
- Full Text
- View/download PDF
228. Mulberry (Morus spp.) Diversity in Jammu and Kashmir
- Author
-
Shabnam, Aftab A, Rathore, M S, Dhar, Anil, Srinivasulu, Y, Chauhan, S S, and Sharma, S P
- Published
- 2016
229. Endoscopic ultrasound-guided gastrojejunostomy to the rescue as a “bridge therapy” for tubercular duodenal obstruction
- Author
-
Dhar, Jahnvi, Mitra, Suvradeep, Sinha, Saroj Kant, and Samanta, Jayanta
- Published
- 2024
- Full Text
- View/download PDF
230. Tate cohomology and local base change of generic representations of ${\rm GL}_3$ -- non-banal case
- Author
-
Dhar, Sabyasachi
- Subjects
Mathematics - Representation Theory - Abstract
Let $F$ be a finite extension of $\mathbb{Q}_p$, and let $E$ be a finite Galois extension of $F$ with degree of extension $l$, where $l$ and $p$ are distinct odd primes. Let $\pi_F$ be an integral, $l$-adic generic representation of ${\rm GL}_3(F)$, and let $\pi_E$ be the base change lifting of $\pi_F$ to ${\rm GL}_3(E)$. Let $J_l(\pi_F)$ (resp. $J_l(\pi_E)$) be the unique generic sub-quotient of the mod-$l$ reduction of $\pi_F$ (resp. $\pi_E$). In this article, using the local converse theorem over local Artinian $\overline{\mathbb{F}}_l$-algebras, we prove that the Frobenius twist of $J_l(\pi_F)$ is isomorphic to the Tate cohomology group $\widehat{H}^0({\rm Gal}(E/F),J_l(\pi_E))$. The result of this article removes the hypothesis that the prime $l$ does not divide the pro-order of ${\rm GL}_2(F)$., Comment: 15 pages
- Published
- 2023
231. A novel characterization of structures in smooth regression curves: from a viewpoint of persistent homology
- Author
-
Kumar, Satish and Dhar, Subhra Sankar
- Subjects
Mathematics - Algebraic Topology ,Statistics - Methodology - Abstract
We characterize structures such as monotonicity, convexity, and modality in smooth regression curves using persistent homology. Persistent homology is a key tool in topological data analysis that detects higher dimensional topological features such as connected components and holes (cycles or loops) in the data. In other words, persistent homology is a multiscale version of homology that characterizes sets based on the connected components and holes. We use super-level sets of functions to extract geometric features via persistent homology. In particular, we explore structures in regression curves via the persistent homology of super-level sets of a function, where the function of interest is - the first derivative of the regression function. In the course of this study, we extend an existing procedure of estimating the persistent homology for the first derivative of a regression function and establish its consistency. Moreover, as an application of the proposed methodology, we demonstrate that the persistent homology of the derivative of a function can reveal hidden structures in the function that are not visible from the persistent homology of the function itself. In addition, we also illustrate that the proposed procedure can be used to compare the shapes of two or more regression curves which is not possible merely from the persistent homology of the function itself., Comment: Following modifications have been made: 1) one paragraph is added in the subsection our contribution. 2) Sketch of the proof is modified. 3) An additional subsection has been incorporated in applications namely, comparison of regression curves. 4) Need and interpretation of supporting lemma's has been emphasized in the appendix
- Published
- 2023
232. Thermalization and hydrodynamics in an interacting integrable system: the case of hard rods
- Author
-
Singh, Sahil Kumar, Dhar, Abhishek, Spohn, Herbert, and Kundu, Anupam
- Subjects
Condensed Matter - Statistical Mechanics - Abstract
We consider the relaxation of an initial non-equilibrium state in a one-dimensional fluid of hard rods. Since it is an interacting integrable system, we expect it to reach the Generalized Gibbs Ensemble (GGE) at long times for generic initial conditions. Here we show that there exist initial conditions for which the system does not reach GGE even at very long times and in the thermodynamic limit. In particular, we consider an initial condition of uniformly distributed hard-rods in a box with the left half having particles with a singular velocity distribution (all moving with unit velocity) and the right half particles in thermal equilibrium. We find that the density profile for the singular component does not spread to the full extent of the box and keeps moving with a fixed effective speed at long times. We show that such density profiles can be well described by the solution of the Euler equations almost everywhere except at the location of the shocks, where we observe slight discrepancies due to dissipation arising from the initial fluctuations of the thermal background. To demonstrate this effect of dissipation analytically, we consider a second initial condition with a single particle at the origin with unit velocity in a thermal background. We find that the probability distribution of the position of the unit velocity quasi-particle has diffusive spreading which can be understood from the solution of the Navier-Stokes equation of the hard rods. Finally, we consider an initial condition with a spread in velocity distribution for which we show convergence to GGE. Our conclusions are based on molecular dynamics simulations supported by analytical arguments.
- Published
- 2023
- Full Text
- View/download PDF
233. A Deep Learning Approach to Teeth Segmentation and Orientation from Panoramic X-rays
- Author
-
Dhar, Mrinal Kanti, Deb, Mou, Madhab, D., and Yu, Zeyun
- Subjects
Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Artificial Intelligence ,Computer Science - Machine Learning - Abstract
Accurate teeth segmentation and orientation are fundamental in modern oral healthcare, enabling precise diagnosis, treatment planning, and dental implant design. In this study, we present a comprehensive approach to teeth segmentation and orientation from panoramic X-ray images, leveraging deep learning techniques. We build our model based on FUSegNet, a popular model originally developed for wound segmentation, and introduce modifications by incorporating grid-based attention gates into the skip connections. We introduce oriented bounding box (OBB) generation through principal component analysis (PCA) for precise tooth orientation estimation. Evaluating our approach on the publicly available DNS dataset, comprising 543 panoramic X-ray images, we achieve the highest Intersection-over-Union (IoU) score of 82.43% and Dice Similarity Coefficient (DSC) score of 90.37% among compared models in teeth instance segmentation. In OBB analysis, we obtain the Rotated IoU (RIoU) score of 82.82%. We also conduct detailed analyses of individual tooth labels and categorical performance, shedding light on strengths and weaknesses. The proposed model's accuracy and versatility offer promising prospects for improving dental diagnoses, treatment planning, and personalized healthcare in the oral domain. Our generated OBB coordinates and codes are available at https://github.com/mrinal054/Instance_teeth_segmentation.
- Published
- 2023
234. Photon-photon correlation of condensed light in a microcavity
- Author
-
Tang, Yijun, Dhar, Himadri Shekhar, Oulton, Rupert F., Nyman, Robert A., and Mintert, Florian
- Subjects
Quantum Physics ,Condensed Matter - Quantum Gases ,Physics - Optics - Abstract
The study of temporal coherence in a Bose-Einstein condensate of photons can be challenging, especially in the presence of correlations between the photonic modes. In this work, we use a microscopic, multimode model of photonic condensation inside a dye-filled microcavity and the quantum regression theorem, to derive an analytical expression for the equation of motion of the photon-photon correlation function. This allows us to derive the coherence time of the photonic modes and identify a nonmonotonic dependence of the temporal coherence of the condensed light with the cutoff frequency of the microcavity., Comment: 12 pages, 5 figures
- Published
- 2023
- Full Text
- View/download PDF
235. Breakdown of Temporal Coherence in Photon Condensates
- Author
-
Tang, Yijun, Dhar, Himadri Shekhar, Oulton, Rupert F., Nyman, Robert A., and Mintert, Florian
- Subjects
Quantum Physics ,Condensed Matter - Quantum Gases ,Physics - Optics - Abstract
The temporal coherence of an ideal Bose gas increases as the system approaches the Bose-Einstein condensation threshold from below, with coherence time diverging at the critical point. However, counter-examples have been observed for condensates of photons formed in an externally pumped, dye-filled microcavity, wherein the coherence time decreases rapidly for increasing particle number above threshold. This paper establishes intermode correlations as the central explanation for the experimentally observed dramatic decrease in the coherence time beyond critical pump power., Comment: 5 pages, 4 figures
- Published
- 2023
- Full Text
- View/download PDF
236. Observation of multiple attractors and diffusive transport in a periodically driven Klein-Gordon chain
- Author
-
Kumar, Umesh, Mishra, Seemant, Kundu, Anupam, and Dhar, Abhishek
- Subjects
Condensed Matter - Statistical Mechanics ,Nonlinear Sciences - Chaotic Dynamics - Abstract
We consider a Klein-Gordon chain that is periodically driven at one end and has dissipation at one or both boundaries. An interesting numerical observation in a recent study~[arXiv:2209.03977] was that for driving frequency in the phonon band, there is a range of values of the driving amplitude $F_d\in (F_1, F_2)$ over which the energy current remains constant. In this range, the system exhibits a "resonant nonlinear wave" (RNW) mode of energy transmission which is a time and space periodic solution. It was noted that the range $(F_1,F_2)$, for which the RNW mode occurs, shrinks with increasing system size $N$ and disappears eventually. Remarkably, we find that the RNW mode is in fact a stable solution even for $F_d$ much larger than $F_2$ and quite large $N$ ($\approx 1000$). For $F_d>F_{2}$, there exists a second attractor which is chaotic. Both attractors have finite basins of attraction and can be reached by appropriate choice of initial conditions. Corresponding to the two attractors for large $F_d$, the system can now be in two nonequilibrium steady states. We improve the perturbative treatment of [arXiv:2209.03977] for the RNW mode by including the contributions of the third harmonics. We also consider the effect of thermal noise at the boundaries and find that the RNW mode is stable for small temperatures. Finally, we present results for a different driving protocol studied in [arXiv:2205.03839] where $F_d$ is taken to scale with system size as $N^{-1/2}$ and there is dissipation only at the non-driven end. We find that the steady state can be characterized by Fourier's law as in [arXiv:2205.03839] for a stochastic model. We point out interesting differences that occur since our dynamics is nonlinear and Hamiltonian. Our results suggest the intriguing possibility of observing the high current carrying RNW phase in experiments by careful preparation of initial conditions., Comment: 11 pages, 14 figures
- Published
- 2023
237. AG Codes Achieve List-decoding Capacity over Constant-sized Fields
- Author
-
Brakensiek, Joshua, Dhar, Manik, Gopi, Sivakanth, and Zhang, Zihan
- Subjects
Computer Science - Information Theory ,Mathematics - Algebraic Geometry - Abstract
The recently-emerging field of higher order MDS codes has sought to unify a number of concepts in coding theory. Such areas captured by higher order MDS codes include maximally recoverable (MR) tensor codes, codes with optimal list-decoding guarantees, and codes with constrained generator matrices (as in the GM-MDS theorem). By proving these equivalences, Brakensiek-Gopi-Makam showed the existence of optimally list-decodable Reed-Solomon codes over exponential sized fields. Building on this, recent breakthroughs by Guo-Zhang and Alrabiah-Guruswami-Li have shown that randomly punctured Reed-Solomon codes achieve list-decoding capacity (which is a relaxation of optimal list-decodability) over linear size fields. We extend these works by developing a formal theory of relaxed higher order MDS codes. In particular, we show that there are two inequivalent relaxations which we call lower and upper relaxations. The lower relaxation is equivalent to relaxed optimal list-decodable codes and the upper relaxation is equivalent to relaxed MR tensor codes with a single parity check per column. We then generalize the techniques of GZ and AGL to show that both these relaxations can be constructed over constant size fields by randomly puncturing suitable algebraic-geometric codes. For this, we crucially use the generalized GM-MDS theorem for polynomial codes recently proved by Brakensiek-Dhar-Gopi. We obtain the following corollaries from our main result. First, randomly punctured AG codes of rate $R$ achieve list-decoding capacity with list size $O(1/\epsilon)$ and field size $\exp(O(1/\epsilon^2))$. Prior to this work, AG codes were not even known to achieve list-decoding capacity. Second, by randomly puncturing AG codes, we can construct relaxed MR tensor codes with a single parity check per column over constant-sized fields, whereas (non-relaxed) MR tensor codes require exponential field size., Comment: 38 pages, STOC 2024
- Published
- 2023
238. Generalized GM-MDS: Polynomial Codes are Higher Order MDS
- Author
-
Brakensiek, Joshua, Dhar, Manik, and Gopi, Sivakanth
- Subjects
Computer Science - Information Theory ,Mathematics - Algebraic Geometry ,Mathematics - Combinatorics - Abstract
The GM-MDS theorem, conjectured by Dau-Song-Dong-Yuen and proved by Lovett and Yildiz-Hassibi, shows that the generator matrices of Reed-Solomon codes can attain every possible configuration of zeros for an MDS code. The recently emerging theory of higher order MDS codes has connected the GM-MDS theorem to other important properties of Reed-Solomon codes, including showing that Reed-Solomon codes can achieve list decoding capacity, even over fields of size linear in the message length. A few works have extended the GM-MDS theorem to other families of codes, including Gabidulin and skew polynomial codes. In this paper, we generalize all these previous results by showing that the GM-MDS theorem applies to any polynomial code, i.e., a code where the columns of the generator matrix are obtained by evaluating linearly independent polynomials at different points. We also show that the GM-MDS theorem applies to dual codes of such polynomial codes, which is non-trivial since the dual of a polynomial code may not be a polynomial code. More generally, we show that GM-MDS theorem also holds for algebraic codes (and their duals) where columns of the generator matrix are chosen to be points on some irreducible variety which is not contained in a hyperplane through the origin. Our generalization has applications to constructing capacity-achieving list-decodable codes as shown in a follow-up work by Brakensiek-Dhar-Gopi-Zhang, where it is proved that randomly punctured algebraic-geometric (AG) codes achieve list-decoding capacity over constant-sized fields., Comment: 34 pages, STOC 2024
- Published
- 2023
239. Bose-Einstein condensation of non-ground-state caesium atoms
- Author
-
Horvath, Milena, Dhar, Sudipta, Das, Arpita, Frye, Matthew D., Guo, Yanliang, Hutson, Jeremy M., Landini, Manuele, and Nägerl, Hanns-Christoph
- Subjects
Condensed Matter - Quantum Gases - Abstract
Bose-Einstein condensates of ultracold atoms serve as low-entropy sources for a multitude of quantum-science applications, ranging from quantum simulation and quantum many-body physics to proof-of-principle experiments in quantum metrology and quantum computing. For stability reasons, in the majority of cases the energetically lowest-lying atomic spin state is used. Here we report the Bose-Einstein condensation of caesium atoms in the Zeeman-excited mf = 2 state, realizing a non-ground-state Bose-Einstein condensate with tunable interactions and tunable loss. We identify two regions of magnetic field in which the two-body relaxation rate is low enough that condensation is possible. We characterize the phase transition and quantify the loss processes, finding unusually high three-body losses in one of the two regions. Our results open up new possibilities for the mixing of quantum-degenerate gases, for polaron and impurity physics, and in particular for the study of impurity transport in strongly correlated one-dimensional quantum wires.
- Published
- 2023
240. Differential Evolution Algorithm based Hyper-Parameters Selection of Convolutional Neural Network for Speech Command Recognition
- Author
-
Dhar, Sandipan, Sen, Anuvab, Bandyopadhyay, Aritra, Jana, Nanda Dulal, Ghosh, Arjun, and Sarayloo, Zahra
- Subjects
Computer Science - Sound ,Computer Science - Neural and Evolutionary Computing ,Electrical Engineering and Systems Science - Audio and Speech Processing - Abstract
Speech Command Recognition (SCR), which deals with identification of short uttered speech commands, is crucial for various applications, including IoT devices and assistive technology. Despite the promise shown by Convolutional Neural Networks (CNNs) in SCR tasks, their efficacy relies heavily on hyper-parameter selection, which is typically laborious and time-consuming when done manually. This paper introduces a hyper-parameter selection method for CNNs based on the Differential Evolution (DE) algorithm, aiming to enhance performance in SCR tasks. Training and testing with the Google Speech Command (GSC) dataset, the proposed approach showed effectiveness in classifying speech commands. Moreover, a comparative analysis with Genetic Algorithm based selections and other deep CNN (DCNN) models highlighted the efficiency of the proposed DE algorithm in hyper-parameter selection for CNNs in SCR tasks., Comment: 8 Pages, 7 Figures, 4 Tables, Accepted by the 15th International Joint Conference on Computational Intelligence (IJCCI 2023), November 13-15, 2023, Rome, Italy
- Published
- 2023
- Full Text
- View/download PDF
241. Multimodal Large Language Model for Visual Navigation
- Author
-
Tsai, Yao-Hung Hubert, Dhar, Vansh, Li, Jialu, Zhang, Bowen, and Zhang, Jian
- Subjects
Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Robotics - Abstract
Recent efforts to enable visual navigation using large language models have mainly focused on developing complex prompt systems. These systems incorporate instructions, observations, and history into massive text prompts, which are then combined with pre-trained large language models to facilitate visual navigation. In contrast, our approach aims to fine-tune large language models for visual navigation without extensive prompt engineering. Our design involves a simple text prompt, current observations, and a history collector model that gathers information from previous observations as input. For output, our design provides a probability distribution of possible actions that the agent can take during navigation. We train our model using human demonstrations and collision signals from the Habitat-Matterport 3D Dataset (HM3D). Experimental results demonstrate that our method outperforms state-of-the-art behavior cloning methods and effectively reduces collision rates.
- Published
- 2023
242. Observation of collapse and revival in a superconducting atomic frequency comb
- Author
-
Redchenko, E. S., Zens, M., Zemlicka, M., Peruzzo, M., Hassani, F., Dhar, H. S., Krimer, D. O., Rotter, S., and Fink, J. M.
- Subjects
Quantum Physics - Abstract
Recent advancements in superconducting circuits have enabled the experimental study of collective behavior of precisely controlled intermediate-scale ensembles of qubits. In this work, we demonstrate an atomic frequency comb formed by individual artificial atoms strongly coupled to a single resonator mode. We observe periodic microwave pulses that originate from a single coherent excitation dynamically interacting with the multi-qubit ensemble. We show that this revival dynamics emerges as a consequence of the constructive and periodic rephasing of the five superconducting qubits forming the vacuum Rabi split comb. In the future, similar devices could be used as a memory with in-situ tunable storage time or as an on-chip periodic pulse generator with non-classical photon statistics.
- Published
- 2023
243. Offset coalescence behaviour of impacting low-surface tension droplet on high-surface-tension droplet
- Author
-
Sarma, Pragyan Kumar, Dhar, Purbarun, and Paul, Anup
- Subjects
Physics - Fluid Dynamics - Abstract
Impact of droplets of varying surface tension and subsequent spreading over a solid surface are inherent features in printing applications. In this regard, an experimental study of impact of two drops of varied surface tension is carried out where the sessile water droplet on a hydrophilic substrate is impacted upon by another droplet of sequentially lowered surface tension. The impacts are studied for different impact velocities and offsets with respect to the mid-plane of the two colliding droplets. Sodium Dodecyl Sulfate (SDS) is used to alter the surface tension without altering the viscosity, to study the various parameters affecting the spreading length viz. the surface tension, offset between the drops, and impact velocity. The spreading lengths are obtained through image processing of the captured footage of the impact dynamics by a high-speed camera. It is found out that upon lowering the surface tension, the maximum and equilibrium spreading length varies to a significant extent also the nature of the spreading dynamics changes. Both side and top-view imaging are performed to understand the overall hydrodynamics. There is also a substantial change in drawback when dissimilarity is surface tension between the impacting droplets exist. Finally, a fit model is obtained to predict the maximum spread length of the various cases., Comment: 38
- Published
- 2023
244. Experience and Evidence are the eyes of an excellent summarizer! Towards Knowledge Infused Multi-modal Clinical Conversation Summarization
- Author
-
Tiwari, Abhisek, Saha, Anisha, Saha, Sriparna, Bhattacharyya, Pushpak, and Dhar, Minakshi
- Subjects
Computer Science - Computation and Language ,Computer Science - Artificial Intelligence - Abstract
With the advancement of telemedicine, both researchers and medical practitioners are working hand-in-hand to develop various techniques to automate various medical operations, such as diagnosis report generation. In this paper, we first present a multi-modal clinical conversation summary generation task that takes a clinician-patient interaction (both textual and visual information) and generates a succinct synopsis of the conversation. We propose a knowledge-infused, multi-modal, multi-tasking medical domain identification and clinical conversation summary generation (MM-CliConSummation) framework. It leverages an adapter to infuse knowledge and visual features and unify the fused feature vector using a gated mechanism. Furthermore, we developed a multi-modal, multi-intent clinical conversation summarization corpus annotated with intent, symptom, and summary. The extensive set of experiments, both quantitatively and qualitatively, led to the following findings: (a) critical significance of visuals, (b) more precise and medical entity preserving summary with additional knowledge infusion, and (c) a correlation between medical department identification and clinical synopsis generation. Furthermore, the dataset and source code are available at https://github.com/NLP-RL/MM-CliConSummation.
- Published
- 2023
- Full Text
- View/download PDF
245. Yang-Lee Zeros of Certain Antiferromagnetic Models
- Author
-
Sedik, Muhammad, Bhat, Junaid Majeed, Dhar, Abhishek, and Shastry, B Sriram
- Subjects
Condensed Matter - Statistical Mechanics ,Mathematical Physics ,Physics - Computational Physics - Abstract
We revisit the somewhat less studied problem of Yang-Lee zeros of the Ising antiferromagnet. For this purpose, we study two models, the nearest-neighbor model on a square lattice, and the more tractable mean-field model corresponding to infinite-ranged coupling between all sites. In the high-temperature limit, we show that the logarithm of the Yang-Lee zeros can be written as a series in half odd integer powers of the inverse temperature, $k$, with the leading term $\sim k^{1/2}$. This result is true in any dimension and for arbitrary lattices. We also show that the coefficients of the expansion satisfy simple identities (akin to sum rules) for the nearest-neighbor case. These new identities are verified numerically by computing the exact partition function for a 2D square lattice of size $16\times16$. For the mean-field model, we write down the partition function (termed the mean-field polynomials) for the ferromagnetic (FM) and antiferromagnetic (AFM) cases, and derive from them the mean-field equations. We analytically show that at high temperatures the zeros of the AFM mean-field polynomial scale as $\sim k^{1/2}$ as well. Using a simple numerical method, we find the roots lie on certain curves (the root curves), in the thermodynamic limit for the mean-field polynomials for the AFM case as well as for the FM one. Our results show a new root curve, that was not found earlier. Our results also clearly illustrate the phase transition expected for the FM and AFM cases, in the language of Yang-Lee zeros. Moreover, for the AFM case, we observe that the root curves separate two distinct phases of zero and non-zero complex staggered magnetization, and thus depict a complex phase boundary.
- Published
- 2023
- Full Text
- View/download PDF
246. A bijective proof of an identity of Berkovich and Uncu
- Author
-
Dhar, Aritram and Mukhopadhyay, Avi
- Subjects
Mathematics - Combinatorics ,Mathematics - Number Theory ,05A15, 05A17, 05A19, 11P81, 11P83, 11P84 - Abstract
The BG-rank BG($\pi$) of an integer partition $\pi$ is defined as $$\text{BG}(\pi) := i-j$$ where $i$ is the number of odd-indexed odd parts and $j$ is the number of even-indexed odd parts of $\pi$. In a recent work, Fu and Tang ask for a direct combinatorial proof of the following identity of Berkovich and Uncu $$B_{2N+\nu}(k,q)=q^{2k^2-k}\left[\begin{matrix}2N+\nu\\N+k\end{matrix}\right]_{q^2}$$ for any integer $k$ and non-negative integer $N$ where $\nu\in \{0,1\}$, $B_N(k,q)$ is the generating function for partitions into distinct parts less than or equal to $N$ with BG-rank equal to $k$ and $\left[\begin{matrix}a+b\\b\end{matrix}\right]_q$ is a Gaussian binomial coefficient. In this paper, we provide a bijective proof of Berkovich and Uncu's identity along the lines of Vandervelde and Fu and Tang's idea., Comment: 18 pages, 8 figures. To appear in S\'eminaire Lotharingien de Combinatoire
- Published
- 2023
247. The few-body problem of particles with only gravitational interactions
- Author
-
Dhar, Deepak
- Subjects
Physics - Popular Physics ,General Relativity and Quantum Cosmology - Abstract
In this article, I discuss the motion of $N$ point masses in non-relativistic mechanics, when the interaction between them is purely the Newtonian gravitational interaction, with $N$ greater than or equal to 2. The dynamical equations of motion cannot be solved in closed form, for general initial conditions, for any $N$ greater than 2. However, the qualitative behavior of the solutions can be understood from general considerations. I discuss in particular motion the three masses on a line, and the counter-intuitive case of four masses on a line that leads to all particles escaping to infinity in a finite time., Comment: Submitted to Physics News
- Published
- 2023
248. MALITE: Lightweight Malware Detection and Classification for Constrained Devices
- Author
-
Anand, Sidharth, Mitra, Barsha, Dey, Soumyadeep, Rao, Abhinav, Dhar, Rupsa, and Vaidya, Jaideep
- Subjects
Computer Science - Cryptography and Security - Abstract
Today, malware is one of the primary cyberthreats to organizations. Malware has pervaded almost every type of computing device including the ones having limited memory, battery and computation power such as mobile phones, tablets and embedded devices like Internet-of-Things (IoT) devices. Consequently, the privacy and security of the malware infected systems and devices have been heavily jeopardized. In recent years, researchers have leveraged machine learning based strategies for malware detection and classification. Malware analysis approaches can only be employed in resource constrained environments if the methods are lightweight in nature. In this paper, we present MALITE, a lightweight malware analysis system, that can classify various malware families and distinguish between benign and malicious binaries. MALITE converts a binary into a gray scale or an RGB image and employs low memory and battery power consuming as well as computationally inexpensive malware analysis strategies. We have designed MALITE-MN, a lightweight neural network based architecture and MALITE-HRF, an ultra lightweight random forest based method that uses histogram features extracted by a sliding window. We evaluate the performance of both on six publicly available datasets (Malimg, Microsoft BIG, Dumpware10, MOTIF, Drebin and CICAndMal2017), and compare them to four state-of-the-art malware classification techniques. The results show that MALITE-MN and MALITE-HRF not only accurately identify and classify malware but also respectively consume several orders of magnitude lower resources (in terms of both memory as well as computation capabilities), making them much more suitable for resource constrained environments.
- Published
- 2023
249. Comparative Evaluation of Metaheuristic Algorithms for Hyperparameter Selection in Short-Term Weather Forecasting
- Author
-
Sen, Anuvab, Mazumder, Arul Rhik, Dutta, Dibyarup, Sen, Udayon, Syam, Pathikrit, and Dhar, Sandipan
- Subjects
Computer Science - Neural and Evolutionary Computing ,Computer Science - Artificial Intelligence - Abstract
Weather forecasting plays a vital role in numerous sectors, but accurately capturing the complex dynamics of weather systems remains a challenge for traditional statistical models. Apart from Auto Regressive time forecasting models like ARIMA, deep learning techniques (Vanilla ANNs, LSTM and GRU networks), have shown promise in improving forecasting accuracy by capturing temporal dependencies. This paper explores the application of metaheuristic algorithms, namely Genetic Algorithm (GA), Differential Evolution (DE), and Particle Swarm Optimization (PSO), to automate the search for optimal hyperparameters in these model architectures. Metaheuristic algorithms excel in global optimization, offering robustness, versatility, and scalability in handling non-linear problems. We present a comparative analysis of different model architectures integrated with metaheuristic optimization, evaluating their performance in weather forecasting based on metrics such as Mean Squared Error (MSE) and Mean Absolute Percentage Error (MAPE). The results demonstrate the potential of metaheuristic algorithms in enhancing weather forecasting accuracy \& helps in determining the optimal set of hyper-parameters for each model. The paper underscores the importance of harnessing advanced optimization techniques to select the most suitable metaheuristic algorithm for the given weather forecasting task., Comment: 8 pages, 3 figures, 2 Tables, Accepted by the 15th International Conference on Evolutionary Computation Theory and Applications (ECTA 2023) to be held as part of IJCCI 2023, November 13-15, 2023, Rome, Italy
- Published
- 2023
- Full Text
- View/download PDF
250. Integrated Image and Location Analysis for Wound Classification: A Deep Learning Approach
- Author
-
Patel, Yash, Shah, Tirth, Dhar, Mrinal Kanti, Zhang, Taiyu, Niezgoda, Jeffrey, Gopalakrishnan, Sandeep, and Yu, Zeyun
- Subjects
Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Artificial Intelligence - Abstract
The global burden of acute and chronic wounds presents a compelling case for enhancing wound classification methods, a vital step in diagnosing and determining optimal treatments. Recognizing this need, we introduce an innovative multi-modal network based on a deep convolutional neural network for categorizing wounds into four categories: diabetic, pressure, surgical, and venous ulcers. Our multi-modal network uses wound images and their corresponding body locations for more precise classification. A unique aspect of our methodology is incorporating a body map system that facilitates accurate wound location tagging, improving upon traditional wound image classification techniques. A distinctive feature of our approach is the integration of models such as VGG16, ResNet152, and EfficientNet within a novel architecture. This architecture includes elements like spatial and channel-wise Squeeze-and-Excitation modules, Axial Attention, and an Adaptive Gated Multi-Layer Perceptron, providing a robust foundation for classification. Our multi-modal network was trained and evaluated on two distinct datasets comprising relevant images and corresponding location information. Notably, our proposed network outperformed traditional methods, reaching an accuracy range of 74.79% to 100% for Region of Interest (ROI) without location classifications, 73.98% to 100% for ROI with location classifications, and 78.10% to 100% for whole image classifications. This marks a significant enhancement over previously reported performance metrics in the literature. Our results indicate the potential of our multi-modal network as an effective decision-support tool for wound image classification, paving the way for its application in various clinical contexts.
- Published
- 2023
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.