227 results on '"Debra K. Sullivan"'
Search Results
202. Effect of successful weight loss program on biomarkers for breast cancer in postmenopausal high-risk women
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J. Donnelly, S. Aversman, Bruce F. Kimler, Jennifer R. Klemp, Henry Yeh, B. Smith, Teresa A. Phillips, Debra K. Sullivan, Carola M. Zalles, and Carol J. Fabian
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Gynecology ,Cancer Research ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Obstetrics ,Weight Loss Program ,Overweight ,Hyperplasia ,medicine.disease ,Breast cancer ,Oncology ,Weight loss ,Biopsy ,Clinical endpoint ,Medicine ,medicine.symptom ,business ,Random Periareolar Fine-Needle Aspiration - Abstract
1522 Background: The proportion of baseline weight or fat loss needed for breast cancer risk reduction in overweight women is not defined. We conducted a pilot study to determine the effect of a structured weight loss program on serum and tissue breast cancer risk biomarkers. Methods: Postmenopausal women with BMI > 25 kg/m2 not on HRT were eligible if they met risk criteria of 5-yr Gail > 1.7%, prior contra- lateral breast cancer, or precancerous biopsy; and had breast tissue harvested by random periareolar fine needle aspiration (RPFNA) indicating evidence of hyperplasia and Ki-67 > 1.5%. Our primary endpoint was to determine the proportion of women with ≥ 5% weight loss and effect on Ki-67. Due to low proportion of women with Ki-67, minimum eligibility criteria were changed to cytomorphology and a frozen aliquot. Our 6-month weight loss intervention included reduced energy diet, physical activity, and weekly meetings for behavioral strategies with other high risk women. Body composition (DEXA), fasting...
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- 2010
203. 937 Weight Loss Can Lead to Complete Resolution of GERD Symptoms: A Prospective Study
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Sachin Wani, Mandeep Singh, Joseph E. Donnelly, Prateek Sharma, Jaehoon Lee, Debra K. Sullivan, Vikas Singh, Neil Gupta, Ajay Bansal, Bryan K. Smith, Srinivas Gaddam, and Amit Rastogi
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Pediatrics ,medicine.medical_specialty ,Hepatology ,business.industry ,Gastroenterology ,medicine.disease ,Complete resolution ,Weight loss ,GERD ,Medicine ,medicine.symptom ,business ,Prospective cohort study ,Lead (electronics) - Published
- 2010
204. M1845 High Prevalence of Reflux Symptoms in Obese Individuals
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Joseph E. Donnelly, Bryan K. Smith, Mandeep Singh, Sachin Wani, Amit Rastogi, Prateek Sharma, Vikas Singh, Ajay Bansal, and Debra K. Sullivan
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Saliva ,medicine.medical_specialty ,Hepatology ,Nerd ,business.industry ,Gastroenterology ,Reflux ,Heartburn ,medicine.disease ,Pathophysiology ,medicine.anatomical_structure ,Internal medicine ,GERD ,medicine ,Gastric acid ,Esophagus ,medicine.symptom ,business - Abstract
Background and Aims: Impaired salivary secretion has been reported to cause abnormal acid clearance from the esophagus in gastroesophageal reflux disease (GERD). However, few studies have explained the differences between nonerosive reflux disease (NERD) and erosive esophagitis (EE) with respect to salivary secretion. We have already reported that a noninvasive salivary functional test, modified glucose clearance test, which enabled the distinction between NERD and EE (Aliment Pharmacol & Ther 2008). According to our report, glucose clearance of EE was significantly lower than that of NERD. Saliva has important functions not only to clear gastric acid but also to regenerate esophageal mucosa by epidermal growth factor (EGF). The purpose of this study was to examine the relation between pathophysiology of GERD and the amount of salivary EGF (sEGF) produced. Subjects and Methods: Twenty patients with heartburn (10 NERD and 10 EE) and 10 healthy volunteers were enrolled in this study after an informed consent was obtained from them. Salivary volume was measured by gum test, and the sEGF concentration in the saliva produced by these patients was determined using a commercially available ELISA kit (Quantikine®, R&D systems). To elucidate the differences among the NERD and EE and control groups, salivary volume (mL/ min), sEGF concentration (pg/mL), and sEGF production (pg/min) were measured. sEGF production was calculated as salivary volume multiplied by sEGF concentration. Results: Salivary volume and sEGF concentration were not statistically different among the study groups. However the sEGF production was significantly lower in the EE group than in the NERD and control groups (Table 1). Conclusions: These results suggest that a decrease in sEGF production may be a cause of erosive esophagitis. Table 1: sEGF in the NERD and EE groups
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- 2009
205. Kansas Get Moving
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Kristin H. Schmelzle, Bryan K. Smith, Cheryl A. Gibson, Richard A. Washburn, Brianne L. Guilford, Joseph E. Donnelly, and Debra K. Sullivan
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Gerontology ,medicine.medical_specialty ,business.industry ,Intervention (counseling) ,Physical activity ,Physical therapy ,medicine ,Physical Therapy, Sports Therapy and Rehabilitation ,Orthopedics and Sports Medicine ,business - Published
- 2007
206. Seasonal Variation in Blood Pressure Among Multiethnic Children
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Jeannine Goetz, Cheryl A. Gibson, and Debra K. Sullivan
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Nutrition and Dietetics ,Blood pressure ,medicine ,Biology ,Seasonality ,medicine.disease ,Food Science ,Demography - Published
- 2006
207. A Childhood Obesity Prevention Program for Pre-Kindergarten Children at Head Start Programs
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Jeannine Goetz, Joseph E. Donnelly, Debra K. Sullivan, Cheryl A. Gibson, and Jerry L. Greene
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Pre kindergarten ,medicine.medical_specialty ,Nutrition and Dietetics ,business.industry ,Family medicine ,Head start ,medicine ,medicine.disease ,business ,Childhood obesity ,Food Science - Published
- 2006
208. Kansas Get Moving
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Brianne L. Guilford, Bryan K. Smith, Cheryl A. Gibson, Debra K. Sullivan, Richard A. Washburn, and Joseph E. Donnelly
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Physical Therapy, Sports Therapy and Rehabilitation ,Orthopedics and Sports Medicine - Published
- 2006
209. A Comparison of a Low Carbohydrate and Low Fat Diet for Weight Maintenance
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Cheryl A. Gibson, Mary C Vernon, Debra K. Sullivan, Eric C. Westman, Elizabeth E. Stewart, James D. LeCheminant, Joseph E. Donnelly, and Sandra Hall
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Chemistry ,Weight maintenance ,Low residue diet ,Physical Therapy, Sports Therapy and Rehabilitation ,Orthopedics and Sports Medicine ,Food science ,Low carbohydrate ,Low fat diet - Published
- 2006
210. The Influence Of High Fat Vs. Low Fat Meals On Snacking Patterns
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Joseph E. Donnelly, Jeff J. Honas, Bryan K. Smith, and Debra K. Sullivan
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Snacking ,business.industry ,High fat ,Medicine ,Physical Therapy, Sports Therapy and Rehabilitation ,Orthopedics and Sports Medicine ,Food science ,business - Published
- 2005
211. The Influence Of Late Night Energy Intake On Weight Change In College Students
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Bruce W. Bailey, Debra K. Sullivan, Joseph E. Donnelly, Gretchen A. Speer, Bryan K. Smith, and Kendra Spaeth
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Gerontology ,Animal science ,Energy (esotericism) ,Weight change ,Environmental science ,Physical Therapy, Sports Therapy and Rehabilitation ,Orthopedics and Sports Medicine - Published
- 2005
212. Dietary habits of college freshmen
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A. Cates and Debra K. Sullivan
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Nutrition and Dietetics ,Food Science - Published
- 2001
213. Nutrient Intakes of Adolescents and Adults with Phenylketonuria
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J. Niehues and Debra K. Sullivan
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Nutrition and Dietetics ,Nutrient ,Animal science ,business.industry ,Dietary Reference Intake ,Statistical significance ,Medicine ,Analysis of variance ,business ,Food Science - Abstract
Eighteen PKU individuals completed three-day food records. Nutrient analysis of the diets was determined using the Minnesota Nutrition Data System for Research. Subjects were divided into three medical formula consumption groups: Adequate (n s =6), Inadequate (n=3) and No Formula (n=9). Adequate formula was defined as consuming ≥ 80% of the Dietary Reference Intake (DRI) of protein from medical formula. Statistical significance was found among the three groups using ANOVA for the mean nutrient intakes of folate (p=0.01), calcium (p 12 . The results of this pilot study suggest that PKU subjects consuming no medical formula or less than adequate amounts of medical formula are at risk for several nutrient deficiencies. Supplementation with vitamins and minerals may be warranted in these subjects.
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- 1999
214. Nutrition Interventions for Cognitive Enhancement (NICE)
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National Institute on Aging (NIA) and Debra K. Sullivan, PhD, RD, Chair and Endowed Professor of Clinical Nutrition
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- 2024
215. An Overnight Weekend Model for Maternal PKU Education and Support
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H. Vespa, Debra K. Sullivan, and L. Gleason
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congenital, hereditary, and neonatal diseases and abnormalities ,Pregnancy ,medicine.medical_specialty ,Nutrition and Dietetics ,business.industry ,Offspring ,Incidence (epidemiology) ,nutritional and metabolic diseases ,Disease ,medicine.disease ,Social support ,Dietary treatment ,Family planning ,Family medicine ,medicine ,MATERNAL PKU ,business ,Psychiatry ,Food Science - Abstract
A high percentage of young women with phenylketonuria (PKU) become pregnant prior to initiating dietary treatment which lowers blood phenylalanine levels to a safe range or have difficulty maintaining blood phenylalanine levels in the treatment range once pregnant. This results in a high incidence of serious birth defects in the offspring. The goals of this education program were to inform, instruct and build relationships among young women with PKU which would be supportive of effective family planning and diet initiation resulting in metabolic control prior to pregnancy. Programming was developed based on studies of young women with PKU indicating social support and attitudes were associated with adherence to medical recommendations. Unique aspects of the overnights, which were held for three consecutive years, are as follows: 1. Young women with PKU are often isolated from each other because of the rarity of their disease. Therefore the young women with PKU were encouraged to attend the overnight with a close friend, partner, and or parent. The significant other received concurrent instruction and could become an on-going source of support. 2. All attendees, followed the diet for PKU for the duration of the event. 3. Workshops that included hands-on learning, cooking activities, family planning, opportunities to "Meet-the-Moms" and self-esteem activities enabled the young women to experience the challenges of a PKU pregnancy and promoted decision-making. Twenty-three young women with PKU participated in the overnights over the three years, nine repeatedly. Of note, approximately 1/3 of the participants had minimal recent contact with PKU professionals and the overnight became a significant source of information and support for them.
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- 1998
216. AGE-RELATED CHANGES IN GLUCOSE DISAPPEARANCE IN RESPONSE TO INSULIN 308
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Masakatsu Goto, Thyyar Ravindranath, W Patrick Zeller, Monika Bhola, and Debra K Sullivan
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medicine.medical_specialty ,Fetus ,Oxidase test ,biology ,business.industry ,Insulin ,medicine.medical_treatment ,Glucose transporter ,Adipose tissue ,Endocrinology ,Internal medicine ,Pediatrics, Perinatology and Child Health ,medicine ,biology.protein ,GLUT2 ,GLUT1 ,business ,GLUT4 - Abstract
Glucose transporters are developmentally regulated. GLUT1 is predominant in the fetus and newborn. GLUT2 in liver and GLUT4 in muscle and fatty tissue are predominant in the adult. GLUT1 is not insulin-regulatable and GLUT4 is insulin regulatable. Therefore, we hypothesize newborn rats could have a different response to insulin than the adult rat. Materials and Methods Ten day old and adult Sprague-Dawley rats were used after a 4 hour fast and an overnight fast, respectively. Radioactive 2DG with/without 10 unit/kg insulin (INS) was injected by cardiac puncture under pentobarbital anesthesia to evaluate glucose disappearance. 2DG was used because 2DG is not metabolized after phospholyration. Blood was serially collected by cardiac puncture at 0, 5,10,15,30 and 45 minutes after the injection. Plasma glucose(PG) concentration and radioactive 2DG concentration were measured by a oxidase method and scintilation counter, respectively. Glucose disappearance was calculated from plasma glucose concentration. Values for PG and 2DG were calculated as percent of initial values of PF and 2DG at 0 minute, respectively. Results PG and 2DG (%) at 45 minutes are in the Table.
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- 1997
217. INFANTS OF DIABETIC MOTHERS (IDM) ARE SENSITIVE TO TNFα. 252
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Hui Yuan Chen, W Patrick Zeller, Debra K Sullivan, Kennith Koschnitzki, and Masakatsu Goto
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medicine.medical_specialty ,Endocrinology ,Internal medicine ,Pediatrics, Perinatology and Child Health ,medicine ,Tumor necrosis factor alpha ,Biology - Published
- 1997
218. The actions of others as determinants of behavior in social trap situations
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Andrew J Reed, Thomas Jensen, Debra K Sullivan, Michael Schwab, and David A. Schroeder
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Interpersonal relationship ,Nonverbal communication ,Sociology and Political Science ,Social Psychology ,Behavioral pattern ,Psychology ,Social psychology ,Social trap ,Consumer behaviour ,Social relation ,Outcome (probability) ,Social influence - Abstract
Three studies were conducted to determine the effects of observing the behaviors of others upon an individual's actions in a simulated social trap situation. In Experiment 1, it was found that merely having the opportunity to make comparative appraisals of the actions of others led to greater competition for a finite common resource than when subjects were physically isolated from one another. In Experiment 2, false feedback was given to subjects to determine if the actions of others alone were responsible for the deleterious effects of having the opportunity for comparative appraisal; it was found that subjects quickly conformed to the behavior pattern of the interacting others, regardless of whether the false feedback indicated that the other subjects were consuming more or less than no-treatment control subjects. Experiment 3 was conducted to determine the motivation of subjects reacting to the actions of others; differential predictions based upon a competition/relative outcome explanation and upon an information search explanation were made. The data were consistent with the information search explanation.
- Published
- 1983
219. Ketogenic Diet Health and Longevity (KDHL)
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University of California, Davis and Debra K. Sullivan, PhD, RD, Department Chair, Dietetics and Nutrition
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- 2023
220. Feasibility and Efficacy of the Ketogenic Diet in Alzheimer's Disease (KDRAFT)
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Debra K. Sullivan, PhD, RD, Debra K Sullivan, PhD, RD, Chair and Endowed Professor of Clinical Nutrition
- Published
- 2018
221. Comparison of a low carbohydrate and low fat diet for weight maintenance in overweight or obese adults enrolled in a clinical weight management program
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Chelsea R. Curry, Mary C Vernon, R.A. Washburn, Debra K. Sullivan, Joseph E. Donnelly, James D. LeCheminant, Cheryl A. Gibson, Sandra Hall, Eric C. Westman, and Elizabeth E. Stewart
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Adult ,Male ,Liquid diet ,Diet, Reducing ,Medicine (miscellaneous) ,lcsh:TX341-641 ,Clinical nutrition ,Overweight ,Diet, Carbohydrate-Restricted ,Animal science ,Weight loss ,Weight management ,Weight Loss ,medicine ,Dietary Carbohydrates ,Humans ,Obesity ,Diet, Fat-Restricted ,lcsh:RC620-627 ,Aged ,Nutrition and Dietetics ,business.industry ,Research ,Body Weight ,Carbohydrate ,Middle Aged ,medicine.disease ,Dietary Fats ,lcsh:Nutritional diseases. Deficiency diseases ,Treatment Outcome ,Biochemistry ,Female ,medicine.symptom ,business ,lcsh:Nutrition. Foods and food supply - Abstract
Background Recent evidence suggests that a low carbohydrate (LC) diet may be equally or more effective for short-term weight loss than a traditional low fat (LF) diet; however, less is known about how they compare for weight maintenance. The purpose of this study was to compare body weight (BW) for participants in a clinical weight management program, consuming a LC or LF weight maintenance diet for 6 months following weight loss. Methods Fifty-five (29 low carbohydrate diet; 26 low fat diet) overweight/obese middle-aged adults completed a 9 month weight management program that included instruction for behavior, physical activity (PA), and nutrition. For 3 months all participants consumed an identical liquid diet (2177 kJ/day) followed by 1 month of re-feeding with solid foods either low in carbohydrate or low in fat. For the remaining 5 months, participants were prescribed a meal plan low in dietary carbohydrate (~20%) or fat (~30%). BW and carbohydrate or fat grams were collected at each group meeting. Energy and macronutrient intake were assessed at baseline, 3, 6, and 9 months. Results The LC group increased BW from 89.2 ± 14.4 kg at 3 months to 89.3 ± 16.1 kg at 9 months (P = 0.84). The LF group decreased BW from 86.3 ± 12.0 kg at 3 months to 86.0 ± 14.0 kg at 9 months (P = 0.96). BW was not different between groups during weight maintenance (P = 0.87). Fifty-five percent (16/29) and 50% (13/26) of participants for the LC and LF groups, respectively, continued to decrease their body weight during weight maintenance. Conclusion Following a 3 month liquid diet, the LC and LF diet groups were equally effective for BW maintenance over 6 months; however, there was significant variation in weight change within each group.
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222. Dietary patterns of early childhood and maternal socioeconomic status in a unique prospective sample from a randomized controlled trial of Prenatal DHA Supplementation
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Debra K. Sullivan, John Colombo, Brandon H. Hidaka, Jocelynn M. Thodosoff, Elizabeth H. Kerling, and Susan E. Carlson
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Adult ,Male ,0301 basic medicine ,Pediatrics ,medicine.medical_specialty ,Docosahexaenoic Acids ,Dietary pattern ,Mothers ,Prenatal care ,Diet Surveys ,03 medical and health sciences ,Pregnancy ,Environmental health ,medicine ,Cluster Analysis ,Humans ,Prospective Studies ,Pediatrics, Perinatology, and Child Health ,Empirically derived ,Refined grains ,Prospective cohort study ,Children ,Prenatal Nutritional Physiological Phenomena ,Socioeconomic status ,2. Zero hunger ,030109 nutrition & dietetics ,business.industry ,food and beverages ,Prenatal Care ,medicine.disease ,United States ,Diet ,3. Good health ,Social Class ,Child, Preschool ,Dietary Supplements ,Pediatrics, Perinatology and Child Health ,Cohort ,Red meat ,Early childhood ,Female ,business ,Multivariate ,Research Article ,Follow-Up Studies - Abstract
Background Dietary habits established in early childhood and maternal socioeconomic status (SES) are important, complex, interrelated factors that influence a child’s growth and development. The aim of this study was to define the major dietary patterns in a cohort of young US children, construct a maternal SES index, and evaluate their associations. Methods The diets of 190 children from a randomized, controlled trial of prenatal supplementation of docosahexaenoic acid (DHA) were recorded at 6-mo intervals from 2-4.5 years by 24-h dietary recall. Hierarchical cluster analysis of age-adjusted, average daily intake of 24 food and beverage groups was used to categorize diet. Unrotated factor analysis generated an SES score from maternal race, ethnicity, age, education, and neighborhood income. Results We identified two major dietary patterns: “Prudent” and “Western.” The 85 (45%) children with a Prudent diet consumed more whole grains, fruit, yogurt and low-fat milk, green and non-starchy vegetables, and nuts and seeds. Conversely, those with a Western diet had greater intake of red meat, discretionary fat and condiments, sweet beverages, refined grains, French fries and potato chips, eggs, starchy vegetables, processed meats, chicken and seafood, and whole-fat milk. Compared to a Western diet, a Prudent diet was associated with one standard deviation higher maternal SES (95% CI: 0.80 to 1.30). Conclusions We found two major dietary patterns of young US children and defined a single, continuous axis of maternal SES that differed strongly between groups. This is an important first step to investigate how child diet, SES, and prenatal DHA supplementation interact to influence health outcomes. Trial registration NCT00266825. Prospectively registered on December 15, 2005 Electronic supplementary material The online version of this article (doi:10.1186/s12887-016-0729-0) contains supplementary material, which is available to authorized users.
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223. Physical activity across the curriculum: year one process evaluation results
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Kristin H. Schmelzle, Joseph E. Donnelly, J. Leon Greene, Matthew S. Mayo, Cheryl A. Gibson, Joseph J. Ryan, Debra K. Sullivan, Bruce W. Bailey, Shannon L. Williams, Katrina D. DuBose, Bryan K. Smith, and Richard A. Washburn
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medicine.medical_specialty ,education ,Physical activity ,Behavioural sciences ,Medicine (miscellaneous) ,Physical Therapy, Sports Therapy and Rehabilitation ,Clinical nutrition ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,law ,Intervention (counseling) ,Medicine ,030212 general & internal medicine ,lcsh:RC620-627 ,Curriculum ,Nutrition and Dietetics ,business.industry ,Research ,lcsh:Public aspects of medicine ,4. Education ,05 social sciences ,050301 education ,lcsh:RA1-1270 ,lcsh:Nutritional diseases. Deficiency diseases ,Physical therapy ,Process evaluation ,business ,0503 education ,Body mass index - Abstract
Background Physical Activity Across the Curriculum (PAAC) is a 3-year elementary school-based intervention to determine if increased amounts of moderate intensity physical activity performed in the classroom will diminish gains in body mass index (BMI). It is a cluster-randomized, controlled trial, involving 4905 children (2505 intervention, 2400 control). Methods We collected both qualitative and quantitative process evaluation data from 24 schools (14 intervention and 10 control), which included tracking teacher training issues, challenges and barriers to effective implementation of PAAC lessons, initial and continual use of program specified activities, and potential competing factors, which might contaminate or lessen program effects. Results Overall teacher attendance at training sessions showed exceptional reach. Teachers incorporated active lessons on most days, resulting in significantly greater student physical activity levels compared to controls (p < 0.0001). Enjoyment ratings for classroom-based lessons were also higher for intervention students. Competing factors, which might influence program results, were not carried out at intervention or control schools or were judged to be minimal. Conclusion In the first year of the PAAC intervention, process evaluation results were instrumental in identifying successes and challenges faced by teachers when trying to modify existing academic lessons to incorporate physical activity.
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224. Treatment of functional bowel disorders in an integrative medicine clinic resulting in improved digestive tract symptoms
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Leigh E Wagner, Kristina M Bridges, Jill M Hinman, Jianghua He, Daniel Buckles, Winnie Dunn, Jeanne Drisko, Debra K Sullivan, and Susan E Carlson
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functional bowel disorders ,functional gastrointestinal disorders ,gluten‐free diet ,integrative medicine ,irritable bowel syndrome ,low fermentable oligosaccharides, disaccharides, monosaccharides, and polyols diet ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Abstract Background and Aim Functional bowel disorders (FBDs), including irritable bowel syndrome (IBS) and others, are conditions without a physically identifiable etiology that, as a result, are difficult to treat. Alternatives to traditional medical interventions are needed because IBS patients require more of physician time and higher healthcare spending. The goal of this study was to determine the efficacy of alternative lifestyle interventions for patients with FBDs seen in an integrative medicine (IM) clinic at an academic medical center. Methods We performed a retrospective chart review to determine whether patients with FBDs had improvement in symptoms following predominantly nutrition‐based IM interventions that included recommendations for dietary supplements and elimination diets. We measured symptoms before and after intervention (average time between measurements 8.75 months) using a medical symptoms questionnaire (MSQ) commonly used to quantify symptom change in IM clinics. Results Digestive tract symptoms, as measured by the MSQ, improved significantly in patients (n = 57) with FBDs following IM intervention. The MSQ Digestive Tract subtotal for FBD patients decreased from 10.2 (SD, 5.4) to 7.2 (SD, 5.2) (P
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- 2024
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225. KU Alternate Meal Energy Level Study (KAMEL)
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Debra K. Sullivan, PhD, RD, Professor
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- 2019
226. Dairy Foods and Blood Pressure in Multi-Ethnic Children
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National Heart, Lung, and Blood Institute (NHLBI) and Debra K. Sullivan, PhD, RD, Chair, Midwest Dairy Professor of Clinical Nutrition
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- 2013
227. Experiences and Perspectives of Polycystic Kidney Disease Patients following a Diet of Reduced Osmoles, Protein, and Acid Precursors Supplemented with Water: A Qualitative Study.
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Jacob M Taylor, Lauren Ptomey, Jill M Hamilton-Reeves, Debra K Sullivan, Catherine Creed, Susan E Carlson, Donald E Wesson, Jared J Grantham, and Cheryl A Gibson
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Medicine ,Science - Abstract
Salt, protein, acid precursors, and fluid intake have been identified as factors that influence cyst growth in ADPKD. Unfortunately, the feasibility of following these dietary restrictions/enhancements from a patient's point-of-view has yet to be studied. The purpose of this study is to understand better the experiences of patients following a relatively complex dietary prescription targeting these factors.Twelve adults with ADPKD and kidney function >30ml/min/1.73m2 were recruited from the University of Kansas Medical Center Polycystic Kidney Disease clinic. In a qualitative design, semi-structured interviews of participants were conducted following a four week dietary intervention (experimental diet lower in sodium, protein, and acid precursors, and supplemented with water) either face-to-face or by telephone. All interviews were recorded, transcribed verbatim, and checked for accuracy. Transcripts were analyzed thematically for emerging themes.Participants reported that eating less meat and more fruits and vegetables were the easiest components of the diet, whereas reaching the daily goal amount of fruits and vegetables and tracking the diet constantly were the most difficult components. Participants had little difficulty with fluid intake and reported the prescribed fluid goal as achievable. The tracking system for fruits and vegetables and protein was reported to be both helpful and intuitive, but tracking their intake on paper was tedious. Eating out was the most significant barrier to following the diet with some individuals avoiding restaurants in order to comply with the dietary prescription.Participants on the experimental diet heightened their awareness of the consumption of dietary salt, protein, acid precursors, and fluid intake. Additionally, most participants believed adherence to the prescribed diet was feasible. However, participants wanted less cumbersome ways to track and monitor the diet, especially given that the prescribed diet is designed for lifelong adherence. Future studies should focus on targeting these specific dietary factors in larger groups of more ethnically and culturally diverse populations to help inform clinicians and how best to help diverse populations adhere to the dietary intervention.ClinicalTrials.gov NCT01810614.
- Published
- 2016
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