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1,731 results on '"Dayong, Wang"'

204. The Protective A673T Mutation of Amyloid Precursor Protein (APP) in Alzheimer’s Disease

Author

YaHui Peng, WenJing Wang, JiaYing Xiao, Xu Gao, BoWen Li, Qing Xia, JiaBin Shi, ZiJie Liu, DaYong Wang, Lei Huang, Yu Zhao, and XinYu Yang

Subjects
0301 basic medicine, biology, Amyloid beta, Point mutation, Neuroscience (miscellaneous), Hippocampus, Disease, 03 medical and health sciences, Cellular and Molecular Neuroscience, 030104 developmental biology, 0302 clinical medicine, medicine.anatomical_structure, Neurology, Cerebral cortex, Mutation (genetic algorithm), medicine, Cancer research, biology.protein, Amyloid precursor protein, Gene, 030217 neurology & neurosurgery
Abstract

Alzheimer's Disease is a progressive neurodegenerative disorder characterized by extracellular amyloid beta peptides, and neurofibrillary tangles consisted of intracellular hyperphosphorylated Tau in the hippocampus and cerebral cortex. Most of the mutations in key genes that code for amyloid precursor protein can lead to significant accumulation of these peptides in the brain and cause Alzheimer's Disease. Moreover, Some point mutations in amyloid precursor protein can cause familial Alzheimer's Disease, such as Swedish mutation and A673V mutation. However, recent studies have found that the A673T mutation in amyloid precursor protein gene can protect against Alzheimer's Disease, even it is located next to the Swedish mutation and at the same site as A673V mutation, which are pathogenic. It makes us curious about the protective A673T mutation. Here, we summarize the most recent insights of A673T mutation, focus on their roles in protective mechanisms against Alzheimer's Disease, and discuss their involvement in future treatment.

Published
2021
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205. Filter-Free Photonic Image-Rejection Down-Conversion for Distributed Antenna Applications

Author

Zhiyu Chen, Feng Yang, Dengcai Yang, Fuzheng Wu, Yunxin Wang, and Dayong Wang

Subjects
lcsh:Applied optics. Photonics, Physics, photonic down-conversion, business.industry, Bandwidth (signal processing), lcsh:TA1501-1820, distributed antenna, Signal, Atomic and Molecular Physics, and Optics, Antenna array, Amplitude modulation, Microwave photonics, image rejection, lcsh:QC350-467, Optoelectronics, Hybrid coupler, Electrical and Electronic Engineering, Antenna (radio), Photonics, business, Phase shift module, lcsh:Optics. Light
Abstract

Photonics-assisted frequency conversion based on cascaded modulators is an effective way to satisfy the requirements of distributed antenna array applications. A filter-free photonic image-rejection down-converter with immunity to dispersion-induced power fading is proposed and demonstrated. The radio frequency (RF) signal from the distributed antenna unit is injected into a dual-drive Mach–Zehnder modulator (DDMZM) through an electrical 90° hybrid coupler (HC), and a single-sideband (SSB) signal is realized. It is then transmitted to the center office by an optical fiber link. At the center office, the modulated RF signal is injected into a dual-polarization dual-parallel MZM (DP-DPMZM) after a polarization controller (PC). Afterwards, an LO signal remodulates it through the Y-DPMZM, and carrier-suppressed SSB modulation is fulfilled via another electrical 90° HC. After the power splitting, quadrature I and Q IF signals can be obtained by a photonics-based continuously adjustable phase shifter. Through a combination of the I/Q IF signals with a low-frequency electrical 90° HC, a photonics image-rejection down-converter based on phase cancellation is realized. Moreover, no optical filter is required; thus, the image-rejection down-converter can work with a large bandwidth. The proposed filter-free photonic image-rejection down-converter is theoretically analyzed and experimentally verified.

Published
2021
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206. Equivalency and Replaceability between Different Permeability Models of Hydrate-Bearing Porous Media When Applied to Numerical Modeling of Hydrate Dissociation: Implications for Model Selection and Parameter Assignment

Author

Dayong Wang, Yanfeng Wang, Ziming Wang, Yongchen Song, Zhiqiang Fan, Wei Wei, Xuehua Huang, Mengxin Li, and Qilin Wang

Subjects
Materials science, Bearing (mechanical), 020209 energy, General Chemical Engineering, Model selection, Energy Engineering and Power Technology, Thermodynamics, Numerical modeling, 02 engineering and technology, law.invention, Permeability (earth sciences), Fuel Technology, 020401 chemical engineering, law, 0202 electrical engineering, electronic engineering, information engineering, 0204 chemical engineering, Hydrate dissociation, Porous medium, Hydrate
Abstract

As a key input parameter in laboratory-scale numerical simulations of the hydrate dissociation process, effective and intrinsic permeability is among the most important factors controlling the hydr...

Published
2021
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207. Induction of Protective Response Associated with Expressional Alterations in Neuronal G Protein-Coupled Receptors in Polystyrene Nanoparticle Exposed Caenorhabditis elegans

Author

Wenting Dong, Dayong Wang, Yunhan Yang, and Qiuli Wu

Subjects
Jnk mapk, 0303 health sciences, biology, Chemistry, General Medicine, 010501 environmental sciences, Toxicology, biology.organism_classification, 01 natural sciences, Polystyrene nanoparticles, Cell biology, 03 medical and health sciences, Phenotypic analysis, Toxicity, Receptor, Caenorhabditis elegans, 030304 developmental biology, 0105 earth and related environmental sciences, G protein-coupled receptor, Transforming growth factor
Abstract

In this study, the association of expressional alterations in neuronal G protein-coupled receptors (GPCRs) with induction of protective response to polystyrene nanoparticles (PS-NPs) was investigated in Caenorhabditis elegans. On the basis of both phenotypic analysis and expression levels, the alterations in expressions of NPR-1, NPR-4, NPR-8, NPR-9, NPR-12, DCAR-1, GTR-1, DOP-2, SER-4, and DAF-37 in neuronal cells mediated the protective response to PS-NPs exposure. In neuronal cells, NPR-9, NPR-12, DCAR-1, and GTR-1 controlled the PS-NPs toxicity by activating or inhibiting JNK-1/JNK MAPK signaling. Neuronal NPR-8, NPR-9, DCAR-1, DOP-2, and DAF-37 controlled the PS-NPs toxicity by activating or inhibiting MPK-1/ERK MAPK signaling. Neuronal NPR-4, NPR-8, NPR-9, NPR-12, GTR-1, DOP-2, and DAF-37 controlled the PS-NPs toxicity by activating or inhibiting DBL-1/TGF-β signaling. Neuronal NPR-1, NPR-4, NPR-12, and GTR-1 controlled the PS-NPs toxicity by activating or inhibiting DAF-7/TGF-β signaling. Our data provides an important neuronal basis for induction of protective response to PS-NPs in C. elegans.

Published
2021
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210. A clinical study involving 72 cases of multiple magnetic beads in the gastrointestinal tract of children

Author

XianLing Li, QinMing Zhang, ShouYan Lu, TingTing Liu, ShuanLing Li, Long Chen, FangNan Xie, Li Wang, ChuangHui Zhang, and DaYong Wang

Abstract

Objective The objective of this study was to better understand the harm caused by accidental ingestion of multiple beads in children and to improve the consequent management outcomes. Materials and Methods Data collected for the analysis of 72 children involved the patient's sex, age, medical history, place of residence (rural or urban) and symptoms, as well as the caregiver's level of education, the location and number of any foreign bodies found during the procedure, whether perforations were confirmed during the procedure, and the number of erroneous ingestion of magnetic beads. Statistical analysis was performed. Results There were no statistical differences between the perforated group and the unperturbed group in terms of age, sex, medical history, and number of magnetic beads ingested (P > 0.05). However, there were statistical differences in white blood cell count (P = 0.048) and c-reactive protein levels (P = 0.033), where values were higher in the perforated group than in the non-perforated group. Conclusion Abdominal ultrasound and/or abdominal upright x-ray analysis should be performed as soon as possible for rapid diagnosis. Immediate surgical intervention is usually required. Given the serious consequences of ingesting such foreign bodies, it is vital to educate parents and/or caregivers not to keep such products away from young children.

Published
2022
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211. Polystyrene nanoparticles cause dynamic alteration in mitochondrial unfolded protein response from parents to the offspring in C. elegans

Author

Ruoran Xu, Xin Hua, Qi Rui, and Dayong Wang

Subjects
History, Environmental Engineering, Polymers and Plastics, Health, Toxicology and Mutagenesis, Microplastics, Public Health, Environmental and Occupational Health, General Medicine, General Chemistry, Pollution, Industrial and Manufacturing Engineering, Receptor, Insulin, Mitochondria, Unfolded Protein Response, Environmental Chemistry, Animals, Nanoparticles, Polystyrenes, Environmental Pollutants, Business and International Management, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Ubiquitins
Abstract

The mitochondrial unfolded protein response (mt UPR) is important for organisms against the toxicity from toxicants and stresses. Polystyrene nanoparticle (PS-NP), one of the emerging pollutants, has aroused increasing concern for its toxicity in the offspring. Nevertheless, the molecular basis for this transgenerational toxicity remains largely unclear. In this study, the role of mt UPR in the induction of transgenerational toxicity was determined in Caenorhabditis elegans (C. elegans) after parental exposure to PS-NP. After exposure to PS-NP (1-100 μg/L), the suppression in mt UPR showed the concentration-dependent in nematodes from P0 generation (P0-G) to F2-G. Moreover, the decreased expression of genes required for controlling mt UPR (atfs-1, dve-1, and ubl-5 genes) were observed from P0-G to F2-G after exposure to PS-NP (1 μg/L). The adverse effects on locomotion and reproductive capacity were more severe over generations in nematodes with RNAi of these three genes, indicating that these genes were involved in controlling transgenerational toxicity. After parental PS-NP exposure (1 μg/L), the mt UPR was significantly inhibited by RNAi of atfs-1, dve-1, and ubl-5, indicating the association between the transgenerational PS-NP toxicity and mt UPR suppression. Additionally, during the transgenerational process, RNAi of atfs-1, dve-1, and ubl-5 enhanced the PS-NP toxicity by suppressing mt UPR, while RNAi of daf-2 encoding an insulin receptor inhibited the PS-NP toxicity by increasing mt UPR. Therefore, our data highlighted the role of inhibition in mt UPR in mediating the transgenerational nanoplastic toxicity in nematodes.

Published
2022

212. Search for resonances decaying to three W bosons in the hadronic final state in proton-proton collisions at s=13 TeV

Author

Viacheslav Bunichev, Mikko Voutilainen, Jordan Nash, Dmitry Kondratyev, Francisco Garcia, Raghunath Pradhan, Gabriella Pugliese, Alberto Escalante del Valle, Praveen Chandra Tiwari, Mate Csanad, Kadir Saygin, Kenneth Bloom, Pietro Govoni, Maximilian Pérez Prada, Arie Bodek, Riccardo Salvatico, Mikhail Dubinin, Andrea Cardini, Chang-Seong Moon, Ted Kolberg, Guenakh Mitselmakher, Kun Shi, Caglar Zorbilmez, Lorenzo Viliani, Ankush Reddy Kanuganti, Wesley Smith, Mikael Myllymäki, Walaa Elmetenawee, Erhan Gülmez, Giovanni Abbiendi, Fabrizio Palla, Valentina Sola, Matthias Schröder, Cristina Riccardi, Johan Borg, Sami Lehti, Abanti Ranadhir Sahasransu, Joseph Reichert, Jussi Viinikainen, Badder Marzocchi, Luke Kreczko, Hugues Lattaud, FLAVIA CETORELLI, Georgios Konstantinos Krintiras, Samet Lezki, Stefano Belforte, Maria Savina, Reza Goldouzian, Márton Bartók, Daniele Fasanella, Erika Garutti, Louis Moureaux, Nadia Pastrone, Danyer Pérez Adán, Muhammad Ahmad, Konstantin Androsov, Toni Sculac, Arun Kumar, Andreas Pfeiffer, Jorge Berenguer Antequera, Giuseppe Della Ricca, Eduard De La Cruz Burelo, Joern Schwandt, Christopher Tully, Luigi Calligaris, Wael HAJ AHMAD (Vael HAJAHMAD), Jennifer Ott, Francisco Javier Cuevas Maestro, Steffen Albrecht, Pablo Matorras-Cuevas, Prabhat Ranjan Pujahari, Alessandra Cappati, Alexander Belyaev, Florian Bury, Roman Kogler, Andrea Giammanco, Marco Toliman Lucchini, Guenther Dissertori, Francesca Cavallari, José María Hernández Calama, Efe Yazgan, Nils Faltermann, Yuri Gershtein, Sinan Sagir, Tomas Lindén, Halil Saka, Luca Cadamuro, Florencia Canelli, Simone Pigazzini, Armando Bermudez Martinez, Dmitri Konstantinov, Ksenia Shchelina, Cesar Augusto Bernardes, Bingran Wang, Qiang Li, Nicolò Trevisani, Tapio Lampén, Md Naimuddin, Barry Blumenfeld, Leonid Levchuk, Claudio Grandi, Giovanni Petrucciani, Dayong Wang, Marco Zanetti, Cristina Botta, Danilo Meuser, Martti Raidal, John Conway, Jaime Leon Holgado, Paolo Giacomelli, Jay R. Dittmann, Yalcin Guler, Agni Bethani, Marcin Konecki, Franco Ligabue, Alexander Grohsjean, Lourdes Urda, Mahmoud Moussa Abdelkhalek Gadallah, Silvano Tosi, Martina Malberti, Merve Ince Lezki, Jochen Schieck, Leonardo Cristella, Ernesto Migliore, Pritam Kalbhor, Silvia Goy Lopez, Ashish Sharma, Tommaso Diotalevi, Nikolaos Manthos, Lisa Benato, Suman Chatterjee, Émilien Chapon, JUAN ALCARAZ MAESTRE, Antonio Vilela Pereira, Álvaro Navarro-Tobar, Thong Q. Nguyen, Zhenbin Wu, Maria Clemencia Mora Herrera, Zhengyun You, Agostino De Iorio, Ilaria Vai, Gilvan Alves, Sandeep Bhowmik, Cristina Fernández Bedoya, Nabin Poudyal, Markus Seidel, Andre Sznajder, Ali Eren Simsek, Tamer Elkafrawy, Pedro Galli Mercadante, Kenyi Hurtado Anampa, Luca Giommi, Efe Yigitbasi, Andrea Massironi, Andrey Starodumov, Jose Ruiz, Mario Pelliccioni, Caroline Collard, Alexei Safonov, WILLIAM FORD, Junghwan Goh, Spandan Mondal, Jingyan Li, German Ruben Martinez, Walter Snoeys, Evgueni Tcherniaev, Matteo Presilla, Stephen Mrenna, Jeremy Andrea, Panja Luukka, Saranya Samik Ghosh, Rogelio Reyes-Almanza, Joachim Mnich, Sandor Lokos, Darin Acosta, Karl Ehatäht, Aurelijus Rinkevicius, Frank Geurts, Isabel Josa Mutuberria, Junquan Tao, Paul Kyberd, Ece ASILAR, David D'Enterria, Daniel Savoiu, Francesco Fienga, Jay Lawhorn, Arabella Martelli, Robert Cousins, Santeri Laurila, Jorma Tuominiemi, Andrey Popov, Jehad Mousa, Martin Grunewald, Paolo Spagnolo, Nicholas Wardle, Redwan Habibullah, Robert Klanner, Frank Golf, Isidro González Caballero, Crisostomo Sciacca, Oscar Gonzalez Lopez, Tahys Janssen, Jeremi Niedziela, Robert Bainbridge, Elizabeth Starling, Andrea Rizzi, Javier Alberto Murillo Quijada, Klaus Rabbertz, Luigi (Gigi) Rolandi, Federica Legger, Andrew Ivanov, ANKITA MEHTA, Ioannis Papadopoulos, Greg Landsberg, Malte Backhaus, Aliakbar Ebrahimi, INSEOK YOON, Sara Fiorendi, ANDREA PICCINELLI, Dmitry Kirpichnikov, Jennifer Ngadiuba, Tamas Almos Vami, Ivan Heredia de la Cruz, Maciej Malawski, Vuko Brigljević, Thomas McCauley, Vittorio Raoul Tavolaro, Pablo Martinez Ruiz del Arbol, Davide Fiorina, Kaur Sandeep, Reddy Pratap Gandrajula, Luca Malgeri, Leszek Grzanka, Peter Elmer, Lea Caminada, Kenneth Osterberg, Leandar Litov, Lata Panwar, Zhicai Zhang, Anton Stepennov, Arnd Meyer, Tatyana Dimova, Christophe Ochando, Alberto Ruiz Jimeno, J B Singh, Johannes Lange, Peter Wittich, Maria Cruz Fouz Iglesias, Korbinian Schweiger, Gaetano Marco Dallavalle, Pietro Faccioli, Rafael Eduardo Sosa Ricardo, Avi Yagil, Muhammad Gul, Jaana Heikkilä, Arne Christoph Reimers, Michele Arneodo, José Flix Molina, Javier Fernandez Menendez, Alexander Tapper, Valeria D'Amante, Sandra S. Padula, George Alverson, Lev Dudko, Juan Pablo Fernández Ramos, Karl Ecklund, Salvatore Costa, Yacine Haddad, Carlos Eugenio Perez Lara, Paolo Meridiani, Ignacio Redondo, Marco Monteno, Gautier Hamel de Monchenault, Salvatore Rappoccio, Gerrit Van Onsem, Thomas Reis, Anna Colaleo, Marco CUFFIANI, Torben Lange, Lutz Feld, Varun Sharma, Gabriella Pásztor, Nicolas Stylianou, Sung-Won Lee, Joel Goldstein, Daniel Diaz, Paolo Azzurri, Oleg Filatov, Welathantri Dharmaratna, ÜMİT SÖZBİLİR, Davide Zuolo, Ram Krishna Sharma, Ian Watson, Javier Mauricio Duarte, Vilius Cepaitis, Andreas Hinzmann, Nikkie Deelen, Matthias Kasemann, Manfred Paulini, Paolo Dini, Andre Frankenthal, Kevin Lannon, Mithat Kaya, Florian Beaudette, Barbara Alvarez Gonzalez, Nuno Leonardo, Maxim Titov, Laurent Forthomme, Jose Enrique Palencia Cortezon, Rainer Wallny, Pietro Vischia, Schoefbeck Robert, Thea Aarrestad, Gaia Grosso, Pieter David, Liuyao Zhang, Tae Jeong Kim, Marco Pieri, Sunil Manohar Dogra, Shabnam Jabeen, Guido Emilio Tonelli, Mar Capeans, Davide Di Croce, Ugur Kiminsu, J.F. Benitez, Luiz Mundim, Jason Lee, Maria Cepeda, Pallabi Das, Ksenia De Leo, Deborah Pinna, Morgan Lethuillier, Soureek Mitra, Bruno Lenzi, Sergio Novaes, Antonio Delgado Peris, Amina Zghiche, Pieter Everaerts, Gurpreet Singh Chahal, Hannu Siikonen, Mohammed Attia Mahmoud, André David Tinoco Mendes, Olga Evdokimov, Pierluigi Bortignon, Shubhanshu Chauhan, Simone Gennai, Freya Blekman, Furkan Dolek, Umberto Dosselli, Federica Maria Simone, Raffaele Gerosa, Benjamin Krikler, Geoffrey Hall, Eija Tuominen, Marko Dragicevic, Antonio Perez-Calero Yzquierdo, Nadezda Chernyavskaya, Mykhailo Dalchenko, Joona Juhani Havukainen, Biagio Rossi, Ibrahim Soner Zorbakir, Sandra Consuegra Rodriguez, Roberto Covarelli, Chiara Amendola, Christophorus Grab, Mojtaba Mohammadi Najafabadi, Henning Flaecher, Dilson De Jesus Damiao, Arthur Moraes, Lucas Taylor, Graham Wilson, Rui Xiao, Minsuk Kim, Alberto Sanchez-Hernandez, Tobias Robert Jakob Kramer, Marino Missiroli, Jan-Frederik Schulte, Fotios Ptochos, Shudhashil Bharthuar, Justin Williams, Helen Heath, Wolfgang Waltenberger, Henning Kirschenmann, Hannes Jung, Emrah Tiras, Camilo Carrillo Montoya, Yu Zhang, Alberto Zucchetta, Ralf Ulrich, Calandri Alessandro, Tahereh Sadat Niknejad, Guillelmo Gomez-Ceballos, Felipe Araujo, Kadri Ozdemir, Patrizia Azzi, Muhammad Alibordi, Vladimir Gavrilov, Johannes Haller, Kati Lassila-Perini, Abhijith Gandrakota, Konstantinos Theofilatos, Gouranga Kole, Eliza Melo da Costa, Andrea Davide Benaglia, Sebastian Wuchterl, Jesus Puerta Pelayo, Laura Martikainen, Ram Krishna Dewanjee, Christophe Delaere, Simon Regnard, Aaron Dominguez, Emanuele Usai, Matthew Herndon, Kenichi Hatakeyama, LUCA GUZZI, Alberto Belloni, Harrison Bertrand Prosper, Federico Siviero, Mariana Shopova, Mauro Donega, Abideh Jafari, Antonio Cassese, Federico De Guio, UTTIYA SARKAR, Aashaq Shah, Oliver Gutsche, Claudio Caputo, Mauro Emanuele Dinardo, Elisabetta Manca, Amedeo Staiano, Soumya Mukherjee, Thiago Rafael Fernandez Perez Tomei, Sudhir Malik, Clemens Lange, and Bożena Boimska

Published
2022
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213. Search for Resonances Decaying to Three W Bosons in Proton-Proton Collisions at s=13 TeV

Author

Viacheslav Bunichev, Mikko Voutilainen, Stefaan Tavernier, Jordan Nash, Francisco Garcia, Raghunath Pradhan, Gabriella Pugliese, Alberto Escalante del Valle, Praveen Chandra Tiwari, Mate Csanad, Kadir Saygin, Kenneth Bloom, Pietro Govoni, Maximilian Pérez Prada, Arie Bodek, Riccardo Salvatico, Mikhail Dubinin, Andrea Cardini, Chang-Seong Moon, Ted Kolberg, Guenakh Mitselmakher, Kun Shi, Caglar Zorbilmez, Lorenzo Viliani, Ankush Reddy Kanuganti, Wesley Smith, Mikael Myllymäki, Hesham El Faham, Walaa Elmetenawee, Erhan Gülmez, Giovanni Abbiendi, Fabrizio Palla, Valentina Sola, Matthias Schröder, Cristina Riccardi, Sami Lehti, Abanti Ranadhir Sahasransu, Joseph Reichert, Jussi Viinikainen, Badder Marzocchi, Luke Kreczko, Hugues Lattaud, FLAVIA CETORELLI, Georgios Konstantinos Krintiras, Samet Lezki, Stefano Belforte, Maria Savina, Reza Goldouzian, Márton Bartók, Daniele Fasanella, Erika Garutti, Shalini Thakur, Louis Moureaux, Nadia Pastrone, Danyer Pérez Adán, Muhammad Ahmad, Konstantin Androsov, Toni Sculac, Arun Kumar, Andreas Pfeiffer, Jorge Berenguer Antequera, Giuseppe Della Ricca, Eduard De La Cruz Burelo, Joern Schwandt, Christopher Tully, Luigi Calligaris, Wael HAJ AHMAD (Vael HAJAHMAD), Jennifer Ott, Francisco Javier Cuevas Maestro, Steffen Albrecht, Pablo Matorras-Cuevas, Prabhat Ranjan Pujahari, Alessandra Cappati, Alexander Belyaev, Florian Bury, James Buchanan, Roman Kogler, Andrea Giammanco, Marco Toliman Lucchini, Guenther Dissertori, Francesca Cavallari, José María Hernández Calama, Antonello Pellecchia, Efe Yazgan, Nils Faltermann, Yuri Gershtein, Sinan Sagir, Tomas Lindén, Halil Saka, Luca Cadamuro, Florencia Canelli, Simone Pigazzini, Armando Bermudez Martinez, Dmitri Konstantinov, Ksenia Shchelina, Cesar Augusto Bernardes, Bingran Wang, Qiang Li, Nicolò Trevisani, Tapio Lampén, Md Naimuddin, Barry Blumenfeld, Leonid Levchuk, Claudio Grandi, Giovanni Petrucciani, Dayong Wang, Marco Zanetti, Cristina Botta, Danilo Meuser, Martti Raidal, John Conway, Jaime Leon Holgado, Paolo Giacomelli, Jay R. Dittmann, Yalcin Guler, Agni Bethani, Marcin Konecki, Franco Ligabue, Alexander Grohsjean, Lourdes Urda, Mahmoud Moussa Abdelkhalek Gadallah, Silvano Tosi, Martina Malberti, Merve Ince Lezki, Jochen Schieck, Leonardo Cristella, Ernesto Migliore, Pritam Kalbhor, Silvia Goy Lopez, Ashish Sharma, Tommaso Diotalevi, Nikolaos Manthos, Lisa Benato, Suman Chatterjee, Émilien Chapon, JUAN ALCARAZ MAESTRE, Antonio Vilela Pereira, Álvaro Navarro-Tobar, Thong Q. Nguyen, Zhenbin Wu, Maria Clemencia Mora Herrera, Zhengyun You, Agostino De Iorio, Ilaria Vai, Gilvan Alves, Sandeep Bhowmik, Cristina Fernández Bedoya, Nabin Poudyal, Markus Seidel, Andre Sznajder, Ali Eren Simsek, Tamer Elkafrawy, Pedro Galli Mercadante, Kenyi Hurtado Anampa, Luca Giommi, Efe Yigitbasi, Andrea Massironi, Andrey Starodumov, Jose Ruiz, Mario Pelliccioni, Caroline Collard, Alexei Safonov, WILLIAM FORD, Junghwan Goh, Spandan Mondal, Jingyan Li, German Ruben Martinez, Walter Snoeys, Evgueni Tcherniaev, Matteo Presilla, Stephen Mrenna, Jeremy Andrea, Panja Luukka, Saranya Samik Ghosh, Rogelio Reyes-Almanza, Joachim Mnich, Sandor Lokos, Darin Acosta, Karl Ehatäht, Aurelijus Rinkevicius, Frank Geurts, Isabel Josa Mutuberria, Junquan Tao, Paul Kyberd, Ece ASILAR, David D'Enterria, Sergey Polikarpov, Daniel Savoiu, Adish Vartak, Francesco Fienga, Jay Lawhorn, Arabella Martelli, Robert Cousins, Santeri Laurila, Jorma Tuominiemi, Andrey Popov, Jehad Mousa, Martin Grunewald, Paolo Spagnolo, Nicholas Wardle, Redwan Habibullah, Robert Klanner, Frank Golf, Isidro González Caballero, Crisostomo Sciacca, Oscar Gonzalez Lopez, Tahys Janssen, Jeremi Niedziela, Robert Bainbridge, Elizabeth Starling, Andrea Rizzi, Javier Alberto Murillo Quijada, Klaus Rabbertz, Luigi (Gigi) Rolandi, Federica Legger, Andrew Ivanov, ANKITA MEHTA, Ioannis Papadopoulos, Greg Landsberg, Malte Backhaus, Aliakbar Ebrahimi, INSEOK YOON, Sara Fiorendi, ANDREA PICCINELLI, Dmitry Kirpichnikov, Jennifer Ngadiuba, Tamas Almos Vami, Ivan Heredia de la Cruz, Maciej Malawski, Vuko Brigljević, Thomas McCauley, Vittorio Raoul Tavolaro, Pablo Martinez Ruiz del Arbol, Davide Fiorina, Kaur Sandeep, Reddy Pratap Gandrajula, Luca Malgeri, Leszek Grzanka, Peter Elmer, Lea Caminada, Kenneth Osterberg, Emil Sørensen Bols, Leandar Litov, Lata Panwar, Zhicai Zhang, Anton Stepennov, Arnd Meyer, Tatyana Dimova, Christophe Ochando, Alberto Ruiz Jimeno, J B Singh, Johannes Lange, Peter Wittich, Maria Cruz Fouz Iglesias, Korbinian Schweiger, Gaetano Marco Dallavalle, Pietro Faccioli, Rafael Eduardo Sosa Ricardo, Avi Yagil, Muhammad Gul, Jaana Heikkilä, Arne Christoph Reimers, Michele Arneodo, José Flix Molina, Javier Fernandez Menendez, Alexander Tapper, Valeria D'Amante, Sandra S. Padula, George Alverson, Lev Dudko, Juan Pablo Fernández Ramos, Karl Ecklund, Martin Delcourt, Salvatore Costa, Yacine Haddad, Paolo Meridiani, Ignacio Redondo, Marco Monteno, Gautier Hamel de Monchenault, Salvatore Rappoccio, Gerrit Van Onsem, Bora Akgun, Thomas Reis, Anna Colaleo, Marco CUFFIANI, Torben Lange, Lutz Feld, Varun Sharma, Gabriella Pásztor, Nicolas Stylianou, Sung-Won Lee, Joel Goldstein, Daniel Diaz, Paolo Azzurri, Oleg Filatov, Welathantri Dharmaratna, Benedikt Vormwald, Davide Zuolo, Ram Krishna Sharma, Ian Watson, Javier Mauricio Duarte, Vilius Cepaitis, Andreas Hinzmann, Nikkie Deelen, Matthias Kasemann, Manfred Paulini, Paolo Dini, Andre Frankenthal, Kevin Lannon, Mithat Kaya, Myriam Schönenberger, Florian Beaudette, Barbara Alvarez Gonzalez, Nuno Leonardo, Maxim Titov, Laurent Forthomme, Jose Enrique Palencia Cortezon, Rainer Wallny, Pietro Vischia, Schoefbeck Robert, Thea Aarrestad, Pieter David, Liuyao Zhang, Tae Jeong Kim, Marco Pieri, Sunil Manohar Dogra, Shabnam Jabeen, Guido Emilio Tonelli, Mar Capeans, Davide Di Croce, Ugur Kiminsu, J.F. Benitez, Luiz Mundim, Jason Lee, Jorgen D'Hondt, Maria Cepeda, Pallabi Das, Ksenia De Leo, Deborah Pinna, Morgan Lethuillier, Soureek Mitra, Bruno Lenzi, Sergio Novaes, Antonio Delgado Peris, Amina Zghiche, Pieter Everaerts, Gurpreet Singh Chahal, Hannu Siikonen, Mohammed Attia Mahmoud, André David Tinoco Mendes, Olga Evdokimov, Pierluigi Bortignon, Shubhanshu Chauhan, Simone Gennai, Freya Blekman, Furkan Dolek, Federica Maria Simone, Raffaele Gerosa, Benjamin Krikler, Geoffrey Hall, Eija Tuominen, Marko Dragicevic, Antonio Perez-Calero Yzquierdo, Nadezda Chernyavskaya, Mykhailo Dalchenko, Joona Juhani Havukainen, Biagio Rossi, Ibrahim Soner Zorbakir, Sandra Consuegra Rodriguez, Roberto Covarelli, Chiara Amendola, Christophorus Grab, Mojtaba Mohammadi Najafabadi, Henning Flaecher, Dilson De Jesus Damiao, Arthur Moraes, Lucas Taylor, Graham Wilson, Rui Xiao, Minsuk Kim, Alberto Sanchez-Hernandez, Tobias Robert Jakob Kramer, Marino Missiroli, Jan-Frederik Schulte, Fotios Ptochos, Shudhashil Bharthuar, Justin Williams, Helen Heath, Wolfgang Waltenberger, Henning Kirschenmann, Hannes Jung, Emrah Tiras, Camilo Carrillo Montoya, Alberto Zucchetta, Ralf Ulrich, Calandri Alessandro, Tahereh Sadat Niknejad, Guillelmo Gomez-Ceballos, Felipe Araujo, Kadri Ozdemir, Patrizia Azzi, Muhammad Alibordi, Vladimir Gavrilov, Johannes Haller, Kati Lassila-Perini, Abhijith Gandrakota, Konstantinos Theofilatos, Gouranga Kole, Eliza Melo da Costa, Andrea Davide Benaglia, Sebastian Wuchterl, Jesus Puerta Pelayo, Laura Martikainen, Ram Krishna Dewanjee, Christophe Delaere, Simon Regnard, Aaron Dominguez, Emanuele Usai, Matthew Herndon, Kenichi Hatakeyama, LUCA GUZZI, Alberto Belloni, Harrison Bertrand Prosper, Federico Siviero, Mariana Shopova, Mauro Donega, Abideh Jafari, Antonio Cassese, Federico De Guio, UTTIYA SARKAR, Aashaq Shah, Oliver Gutsche, Claudio Caputo, Mauro Emanuele Dinardo, Elisabetta Manca, Amedeo Staiano, Soumya Mukherjee, Thiago Rafael Fernandez Perez Tomei, Sudhir Malik, Clemens Lange, and Bożena Boimska

Subjects
General Physics and Astronomy
Published
2022
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214. Hedgehog signaling regulates the development and treatment of glioblastoma (Review)

Author

Hongping, Wang, Qun, Lai, Dayong, Wang, Jian, Pei, Baogang, Tian, Yunhe, Gao, Zhaoguo, Gao, and Xiang, Xu

Subjects
Cancer Research, Oncology
Abstract

Glioblastoma (GBM) is the most common and fatal malignant tumor type of the central nervous system. GBM affects public health and it is important to identify biomarkers to improve diagnosis, reduce drug resistance and improve prognosis (e.g., personalized targeted therapies). Hedgehog (HH) signaling has an important role in embryonic development, tissue regeneration and stem cell renewal. A large amount of evidence indicates that both normative and non-normative HH signals have an important role in GBM. The present study reviewed the role of the HH signaling pathway in the occurrence and progression of GBM. Furthermore, the effectiveness of drugs that target different components of the HH pathway was also examined. The HH pathway has an important role in reversing drug resistance after GBM conventional treatment. The present review highlighted the relevance of HH signaling in GBM and outlined that this pathway has a key role in the occurrence, development and treatment of GBM.

Published
2022
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215. Measurement of the production cross section for Z+b jets in proton-proton collisions at s=13 TeV

Author

Mikko Voutilainen, Stefaan Tavernier, Jordan Nash, Dmitry Kondratyev, Francisco Garcia, Raghunath Pradhan, Gabriella Pugliese, Alberto Escalante del Valle, Praveen Chandra Tiwari, Mate Csanad, Kadir Saygin, Kenneth Bloom, Pietro Govoni, Maximilian Pérez Prada, Arie Bodek, Riccardo Salvatico, Mikhail Dubinin, Andrea Cardini, Chang-Seong Moon, Ted Kolberg, Guenakh Mitselmakher, Kun Shi, Caglar Zorbilmez, Lorenzo Viliani, Ankush Reddy Kanuganti, Wesley Smith, Mikael Myllymäki, Hesham El Faham, Walaa Elmetenawee, Erhan Gülmez, Giovanni Abbiendi, Fabrizio Palla, Valentina Sola, Matthias Schröder, Cristina Riccardi, Sami Lehti, Abanti Ranadhir Sahasransu, Joseph Reichert, Jussi Viinikainen, Badder Marzocchi, Luke Kreczko, Hugues Lattaud, FLAVIA CETORELLI, Georgios Konstantinos Krintiras, Samet Lezki, Stefano Belforte, Maria Savina, Reza Goldouzian, Márton Bartók, Daniele Fasanella, Erika Garutti, Louis Moureaux, Nadia Pastrone, Danyer Pérez Adán, Muhammad Ahmad, Konstantin Androsov, Toni Sculac, Arun Kumar, Andreas Pfeiffer, Jorge Berenguer Antequera, Giuseppe Della Ricca, Eduard De La Cruz Burelo, Joern Schwandt, Christopher Tully, Luigi Calligaris, Wael HAJ AHMAD (Vael HAJAHMAD), Jennifer Ott, Francisco Javier Cuevas Maestro, Steffen Albrecht, Pablo Matorras-Cuevas, Prabhat Ranjan Pujahari, Alessandra Cappati, Alexander Belyaev, Florian Bury, Roman Kogler, Andrea Giammanco, Marco Toliman Lucchini, Guenther Dissertori, Francesca Cavallari, José María Hernández Calama, Efe Yazgan, Nils Faltermann, Yuri Gershtein, Sinan Sagir, Tomas Lindén, Halil Saka, Luca Cadamuro, Florencia Canelli, Simone Pigazzini, Armando Bermudez Martinez, Dmitri Konstantinov, Ksenia Shchelina, Cesar Augusto Bernardes, Bingran Wang, Qiang Li, Richard Breedon, Nicolò Trevisani, Tapio Lampén, Md Naimuddin, Barry Blumenfeld, Leonid Levchuk, Claudio Grandi, Giovanni Petrucciani, Dayong Wang, Marco Zanetti, Cristina Botta, Danilo Meuser, Martti Raidal, John Conway, Jaime Leon Holgado, Paolo Giacomelli, Jay R. Dittmann, Yalcin Guler, Agni Bethani, Marcin Konecki, Franco Ligabue, Alexander Grohsjean, Lourdes Urda, Mahmoud Moussa Abdelkhalek Gadallah, Silvano Tosi, Martina Malberti, Merve Ince Lezki, Jochen Schieck, Leonardo Cristella, Ernesto Migliore, Pritam Kalbhor, Silvia Goy Lopez, Ashish Sharma, Tommaso Diotalevi, Nikolaos Manthos, Lisa Benato, Suman Chatterjee, Émilien Chapon, JUAN ALCARAZ MAESTRE, Antonio Vilela Pereira, Álvaro Navarro-Tobar, Thong Q. Nguyen, Zhenbin Wu, Maria Clemencia Mora Herrera, Zhengyun You, Agostino De Iorio, Ilaria Vai, Gilvan Alves, Sandeep Bhowmik, Cristina Fernández Bedoya, Nabin Poudyal, Markus Seidel, Andre Sznajder, Ali Eren Simsek, Tamer Elkafrawy, Pedro Galli Mercadante, Kenyi Hurtado Anampa, Luca Giommi, Efe Yigitbasi, Andrea Massironi, Andrey Starodumov, Jose Ruiz, Mario Pelliccioni, Caroline Collard, Alexei Safonov, WILLIAM FORD, Junghwan Goh, Spandan Mondal, Jingyan Li, German Ruben Martinez, Walter Snoeys, Evgueni Tcherniaev, Matteo Presilla, Stephen Mrenna, Jeremy Andrea, Panja Luukka, Saranya Samik Ghosh, Rogelio Reyes-Almanza, Joachim Mnich, Sandor Lokos, Fonseca de Souza Sandro, Darin Acosta, Karl Ehatäht, Aurelijus Rinkevicius, Frank Geurts, Isabel Josa Mutuberria, Junquan Tao, Paul Kyberd, Ece ASILAR, David D'Enterria, Sergey Polikarpov, Daniel Savoiu, Adish Vartak, Francesco Fienga, Jay Lawhorn, Arabella Martelli, Robert Cousins, Santeri Laurila, Jorma Tuominiemi, Andrey Popov, Jehad Mousa, Martin Grunewald, Tirso Alejandro Gomez Espinosa, Paolo Spagnolo, Nicholas Wardle, Redwan Habibullah, Robert Klanner, Frank Golf, Isidro González Caballero, Crisostomo Sciacca, Oscar Gonzalez Lopez, Tahys Janssen, Jeremi Niedziela, Robert Bainbridge, Elizabeth Starling, Andrea Rizzi, Javier Alberto Murillo Quijada, Klaus Rabbertz, Luigi (Gigi) Rolandi, Federica Legger, Andrew Ivanov, ANKITA MEHTA, Ioannis Papadopoulos, Greg Landsberg, Malte Backhaus, Aliakbar Ebrahimi, INSEOK YOON, Sara Fiorendi, ANDREA PICCINELLI, Dmitry Kirpichnikov, Arsen Khvedelidze, Jennifer Ngadiuba, Tamas Almos Vami, Ivan Heredia de la Cruz, Maciej Malawski, Vuko Brigljević, Thomas McCauley, Vittorio Raoul Tavolaro, Pablo Martinez Ruiz del Arbol, Davide Fiorina, Kaur Sandeep, Reddy Pratap Gandrajula, Luca Malgeri, Leszek Grzanka, Peter Elmer, Lea Caminada, Kenneth Osterberg, Emil Sørensen Bols, Leandar Litov, Lata Panwar, Zhicai Zhang, Anton Stepennov, Arnd Meyer, Tatyana Dimova, Christophe Ochando, Gabriel Ramirez Sanchez, Alberto Ruiz Jimeno, J B Singh, Johannes Lange, Peter Wittich, Maria Cruz Fouz Iglesias, Korbinian Schweiger, Gaetano Marco Dallavalle, Pietro Faccioli, Rafael Eduardo Sosa Ricardo, Avi Yagil, Muhammad Gul, Jaana Heikkilä, Arne Christoph Reimers, Michele Arneodo, José Flix Molina, Javier Fernandez Menendez, Alexander Tapper, Valeria D'Amante, Sandra S. Padula, George Alverson, Lev Dudko, Juan Pablo Fernández Ramos, Karl Ecklund, Martin Delcourt, Salvatore Costa, Yacine Haddad, Carlos Eugenio Perez Lara, Paolo Meridiani, Ignacio Redondo, Marco Monteno, Gautier Hamel de Monchenault, Salvatore Rappoccio, Gerrit Van Onsem, Thomas Reis, Anna Colaleo, Marco CUFFIANI, Torben Lange, Lutz Feld, Varun Sharma, Gabriella Pásztor, Nicolas Stylianou, Sung-Won Lee, Joel Goldstein, Daniel Diaz, Paolo Azzurri, Oleg Filatov, Sergio Lo Meo, Welathantri Dharmaratna, ÜMİT SÖZBİLİR, Davide Zuolo, Ram Krishna Sharma, Ian Watson, Javier Mauricio Duarte, Vilius Cepaitis, Andreas Hinzmann, Nikkie Deelen, Matthias Kasemann, Manfred Paulini, Paolo Dini, Andre Frankenthal, Kevin Lannon, Mithat Kaya, Florian Beaudette, Barbara Alvarez Gonzalez, Nuno Leonardo, Maxim Titov, Laurent Forthomme, Jose Enrique Palencia Cortezon, Rainer Wallny, Pietro Vischia, Schoefbeck Robert, Thea Aarrestad, Kevin Mota Amarilo, Gaia Grosso, Pieter David, Liuyao Zhang, Tae Jeong Kim, Marco Pieri, Sunil Manohar Dogra, Shabnam Jabeen, Guido Emilio Tonelli, Mar Capeans, Davide Di Croce, Upul Sonnadara, Ugur Kiminsu, J.F. Benitez, Luiz Mundim, Jason Lee, Jorgen D'Hondt, Maria Cepeda, Pallabi Das, Ksenia De Leo, Deborah Pinna, Morgan Lethuillier, Soureek Mitra, Bruno Lenzi, Sergio Novaes, Antonio Delgado Peris, Amina Zghiche, Pieter Everaerts, Gurpreet Singh Chahal, Hannu Siikonen, Mohammed Attia Mahmoud, André David Tinoco Mendes, Olga Evdokimov, Pierluigi Bortignon, Shubhanshu Chauhan, Carlos Perez Dengra, Simone Gennai, Freya Blekman, Furkan Dolek, Umberto Dosselli, Federica Maria Simone, Raffaele Gerosa, Benjamin Krikler, Geoffrey Hall, Eija Tuominen, Marko Dragicevic, Antonio Perez-Calero Yzquierdo, Nadezda Chernyavskaya, Mykhailo Dalchenko, Joona Juhani Havukainen, Biagio Rossi, Ibrahim Soner Zorbakir, Pavel Parygin, Sandra Consuegra Rodriguez, Roberto Covarelli, Chiara Amendola, Christophorus Grab, Mojtaba Mohammadi Najafabadi, Henning Flaecher, Dilson De Jesus Damiao, Arthur Moraes, Lucas Taylor, Graham Wilson, Rui Xiao, Minsuk Kim, Francisco Matorras, Alberto Sanchez-Hernandez, Tobias Robert Jakob Kramer, Marino Missiroli, Jan-Frederik Schulte, Fotios Ptochos, Shudhashil Bharthuar, Justin Williams, Helen Heath, Wolfgang Waltenberger, Henning Kirschenmann, Hannes Jung, Emrah Tiras, Camilo Carrillo Montoya, Yu Zhang, Alberto Zucchetta, Ralf Ulrich, Calandri Alessandro, Tahereh Sadat Niknejad, Guillelmo Gomez-Ceballos, Felipe Araujo, Kadri Ozdemir, Patrizia Azzi, Muhammad Alibordi, Vladimir Gavrilov, Johannes Haller, Kati Lassila-Perini, Abhijith Gandrakota, Konstantinos Theofilatos, Gouranga Kole, Eliza Melo da Costa, Andrea Davide Benaglia, Sebastian Wuchterl, Jesus Puerta Pelayo, Laura Martikainen, Ram Krishna Dewanjee, Christophe Delaere, Simon Regnard, Aaron Dominguez, Emanuele Usai, Matthew Herndon, Kenichi Hatakeyama, LUCA GUZZI, Alberto Belloni, Harrison Bertrand Prosper, Federico Siviero, Mariana Shopova, Mauro Donega, Abideh Jafari, Antonio Cassese, Federico De Guio, UTTIYA SARKAR, Aashaq Shah, Oliver Gutsche, Claudio Caputo, Mauro Emanuele Dinardo, Elisabetta Manca, Amedeo Staiano, Soumya Mukherjee, Thiago Rafael Fernandez Perez Tomei, Sudhir Malik, Clemens Lange, and Bożena Boimska

Published
2022
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217. Exposure to nanopolystyrene and its 4 chemically modified derivatives at predicted environmental concentrations causes differently regulatory mechanisms in nematode Caenorhabditis elegans

Author

Man Qu, He Chen, Hanpeng Lai, Xing Liu, Dayong Wang, and Xing Zhang

Subjects
Environmental Engineering, Health, Toxicology and Mutagenesis, Microplastics, Public Health, Environmental and Occupational Health, General Medicine, General Chemistry, Pollution, Oxidative Stress, Transforming Growth Factor beta, Environmental Chemistry, Animals, Nanoparticles, Polystyrenes, Caenorhabditis elegans, Caenorhabditis elegans Proteins
Abstract

Nanoplastics represented by nanopolystyrene (NPS) and its chemically modified derivatives are environmentally ecotoxicological hotpots in recent years, but their toxicity and underlying mechanisms have not been fully identified. Here we employed Caenorhabditis elegans as an animal model to systematically compare the toxicity between nanopolystyrene and its 4 chemically modified derivatives (PS-PEG, PS-COOH, PS-SOOOH and PS-NH

Published
2022

224. Transcriptomic analysis of gene expression in mice treated with troxerutin.

Author

Yuerong Wang, Shuangshuang Wei, Lintao Chen, Jinli Pei, Hao Wu, Yechun Pei, Yibo Chen, and Dayong Wang

Subjects
Medicine, Science
Abstract

Troxerutin, a semi-synthetic derivative of the natural bioflavanoid rutin, has been reported to possess many beneficial effects in human bodies, such as vasoprotection, immune support, anti-inflammation and anti-aging. However, the effects of troxerutin on genome-wide transcription in blood cells are still unknown. In order to find out effects of troxerutin on gene transcription, a high-throughput RNA sequencing was employed to analysis differential gene expression in blood cells consisting of leucocytes, erythrocytes and platelets isolated from the mice received subcutaneous injection of troxerutin. Transcriptome analysis demonstrated that the expression of only fifteen genes was significantly changed by the treatment with troxerutin, among which 5 genes were up-regulated and 10 genes were down-regulated. Bioinformatic analysis of the fifteen differentially expressed genes was made by utilizing the Gene Ontology (GO), and the differential expression induced by troxerutin was further evaluated by real-time quantitative PCR (Q-PCR).

Published
2017
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225. Honokiol induces superoxide production by targeting mitochondrial respiratory chain complex I in Candida albicans.

Author

Lingmei Sun, Kai Liao, and Dayong Wang

Subjects
Medicine, Science
Abstract

Honokiol, a compound extracted from Magnolia officinalis, has antifungal activities by inducing mitochondrial dysfunction and triggering apoptosis in Candida albicans. However, the mechanism of honokiol-induced oxidative stress is poorly understood. The present investigation was designed to determine the specific mitochondrial reactive oxygen species (ROS)-generation component.We found that honokiol induced mitochondrial ROS accumulation, mainly superoxide anions (O2•-) measured by fluorescent staining method. The mitochondrial respiratory chain complex I (C I) inhibitor rotenone completely blocked O2•- production and provided the protection from the killing action of honokiol. Moreover, respiratory activity and the C I enzyme activity was significantly reduced after honokiol treatment. The differential gene-expression profile also showed that genes involved in oxidoreductase activity, electron transport, and oxidative phosphorylation were upregulated.The present work shows that honokiol may bind to mitochondrial respiratory chain C I, leading to mitochondrial dysfunction, accompanied by increased cellular superoxide anion and oxidative stress.This work not only provides insights on the mechanism by which honokiol interferes with fungal cell, demonstrating previously unknown effects on mitochondrial physiology, but also raises a note of caution on the use of M. officinalis as a Chinese medicine due to the toxic for mitochondria and suggests the possibility of using honokiol as chemosensitizer.

Published
2017
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226. Honokiol induces reactive oxygen species-mediated apoptosis in Candida albicans through mitochondrial dysfunction.

Author

Lingmei Sun, Kai Liao, Chengcheng Hang, and Dayong Wang

Subjects
Medicine, Science
Abstract

OBJECTIVE:To investigate the effects of honokiol on induction of reactive oxygen species (ROS), antioxidant defense systems, mitochondrial dysfunction, and apoptosis in Candida albicans. METHODS:To measure ROS accumulation, 2',7'-dichlorofluorescein diacetate fluorescence was used. Lipid peroxidation was assessed using both fluorescence staining and a thiobarbituric acid reactive substances (TBARS) assay. Protein oxidation was determined using dinitrophenylhydrazine derivatization. Antioxidant enzymatic activities were measured using commercially available detection kits. Superoxide dismutase (SOD) genes expression was measured using real time RT-PCR. To assess its antifungal abilities and effectiveness on ROS accumulation, honokiol and the SOD inhibitor N,N'-diethyldithiocarbamate (DDC) were used simultaneously. Mitochondrial dysfunction was assessed by measuring the mitochondrial membrane potential (mtΔψ). Honokiol-induced apoptosis was assessed using an Annexin V-FITC apoptosis detection kit. RESULTS:ROS, lipid peroxidation, and protein oxidation occurred in a dose-dependent manner in C. albicans after honokiol treatment. Honokiol caused an increase in antioxidant enzymatic activity. In addition, honokiol treatment induced SOD genes expression in C. albicans cells. Moreover, addition of DDC resulted in increased endogenous ROS levels and potentiated the antifungal activity of honokiol. Mitochondrial dysfunction was confirmed by measured changes to mtΔψ. The level of apoptosis increased in a dose-dependent manner after honokiol treatment. CONCLUSIONS:Collectively, these results indicate that honokiol acts as a pro-oxidant in C. albicans. Furthermore, the SOD inhibitor DDC can be used to potentiate the activity of honokiol against C. albicans.

Published
2017
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227. Molecular Control of Innate Immune Response to Pseudomonas aeruginosa Infection by Intestinal let-7 in Caenorhabditis elegans.

Author

Lingtong Zhi, Yonglin Yu, Xueying Li, Daoyong Wang, and Dayong Wang

Subjects
Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5
Abstract

The microRNA (miRNA) let-7 is an important miRNA identified in Caenorhabditis elegans and has been shown to be involved in the control of innate immunity. The underlying molecular mechanisms for let-7 regulation of innate immunity remain largely unclear. In this study, we investigated the molecular basis for intestinal let-7 in the regulation of innate immunity. Infection with Pseudomonas aeruginosa PA14 decreased let-7::GFP expression. Intestine- or neuron-specific activity of let-7 was required for its function in the regulation of innate immunity. During the control of innate immune response to P. aeruginosa PA14 infection, SDZ-24 was identified as a direct target for intestinal let-7. SDZ-24 was found to be predominantly expressed in the intestine, and P. aeruginosa PA14 infection increased SDZ-24::GFP expression. Intestinal let-7 regulated innate immune response to P. aeruginosa PA14 infection by suppressing both the expression and the function of SDZ-24. Knockout or RNA interference knockdown of sdz-24 dampened the resistance of let-7 mutant to P. aeruginosa PA14 infection. Intestinal overexpression of sdz-24 lacking 3'-UTR inhibited the susceptibility of nematodes overexpressing intestinal let-7 to P. aeruginosa PA14 infection. In contrast, we could observed the effects of intestinal let-7 on innate immunity in P. aeruginosa PA14 infected transgenic strain overexpressing sdz-24 containing 3'-UTR. In the intestine, certain SDZ-24-mediated signaling cascades were formed for nematodes against the P. aeruginosa PA14 infection. Our results highlight the crucial role of intestinal miRNAs in the regulation of the innate immune response to pathogenic infection.

Published
2017
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228. Dysregulation of G protein-coupled receptors in the intestine by nanoplastic exposure inCaenorhabditis elegans

Author

Dayong Wang, Yunhan Yang, and Qiuli Wu

Subjects
0303 health sciences, biology, Materials Science (miscellaneous), Wnt signaling pathway, 010501 environmental sciences, biology.organism_classification, 01 natural sciences, Cell biology, 03 medical and health sciences, Mitochondrial unfolded protein response, Toxicity, Signal transduction, Protein kinase A, Receptor, Caenorhabditis elegans, 030304 developmental biology, 0105 earth and related environmental sciences, General Environmental Science, G protein-coupled receptor
Abstract

After their uptake, environmental toxicants may cause toxicity to organisms by activating or inhibiting certain G protein-coupled receptors (GPCRs). Nevertheless, the roles of GPCRs in mediating the response of organisms to nanoplastic exposure are still largely unclear. We here employed Caenorhabditis elegans as an animal model and focused on the identification of intestinal GPCRs required for control of the toxicity of nanopolystyrene (100 nm). Based on gene expression and functional analysis, we identified 13 GPCRs (PAQR-2, NPR-1, DOP-2, CED-1, NPR-9, FSHR-1, DCAR-1, NPR-12, NPR-4, SER-4, DAF-37, GTR-1, and NPR-8) involved in the control of nanopolystyrene toxicity. Moreover, among these identified GPCRs, only PAQR-2 and FSHR-1 acted in the intestine to regulate nanopolystyrene toxicity. PAQR-2 and FSHR-1 regulated nanopolystyrene toxicity in the intestine by at least modulating the activities of insulin, Wnt, p38 mitogen-activated protein kinase (MAPK), ELT-2, and/or mitochondrial unfolded protein response (mt UPR) signaling pathways. Therefore, our results provide a crucial basis for understanding the functions of GPCRs in the intestine to mediate the response to nanoplastic exposure in organisms.

Published
2021
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229. Nodal-loop half metallicity in a two-dimensional Fe4N2 pentagon crystal with room-temperature ferromagnetism

Author

Xiaojun Wu, Dayong Wang, Jinlong Yang, Minglong Chen, Kai Zhang, and Haifeng Lv

Subjects
Crystal, Physics, symbols.namesake, Tetragonal crystal system, Spintronics, Ferromagnetism, Condensed matter physics, Magnetism, Fermi level, Dirac (software), symbols, General Materials Science, Half-metal
Abstract

Two-dimensional (2D) materials with fully spin-polarized nodal-loop band crossing are a class of topological magnetic materials, holding promise for high-speed low-dissipation spintronic devices. Recently, several 2D nodal-loop materials have been reported in theory and experiment, such as Cu2Si, Be2C, CuSe, and Cr2S3 monolayers, adopting triangular, tetragonal, hexagonal, or complex lattices. However, a 2D nodal-loop half metal with room-temperature magnetism is still less reported. Here, we report that the 2D Fe4N2 pentagon crystal is a nodal-loop half metal with room-temperature magnetism over 428 K and a global minimum structure via first-principles calculations and global structure search. The Dirac nodal lines in Fe4N2 form a flat nodal loop at the Fermi level and a spin-polarized type-II nodal-loop above the Fermi level, which are protected by mirror symmetry. Our results establish Fe4N2 as a platform to obtain nodal-loop half metallicity in the 2D pentagon lattice and provide opportunities to build high-speed low-dissipation spintronics in the nanoscale.

Published
2021
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230. Notch receptor GLP-1 regulates toxicity of simulated microgravity stress by activating germline-intestine communication of insulin signaling in C. elegans

Author

Huanliang Liu, Dayong Wang, and Lijie Tian

Subjects
0301 basic medicine, endocrine system, Biophysics, Notch signaling pathway, Biochemistry, Germline, 03 medical and health sciences, 0302 clinical medicine, Stress, Physiological, RNA interference, Animals, Insulin, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Molecular Biology, Weightlessness Simulation, Gene knockdown, Receptors, Notch, biology, Nucleus localization, Chemistry, fungi, Forkhead Transcription Factors, Cell Biology, biology.organism_classification, Cell biology, Intestines, Insulin receptor, Germ Cells, 030104 developmental biology, Organ Specificity, 030220 oncology & carcinogenesis, Toxicity, biology.protein, RNA Interference, Signal Transduction
Abstract

We here investigated molecular basis of notch receptor GLP-1 in controlling simulated microgravity stress in Caenorhabditis elegans. glp-1 expression was decreased by simulated microgravity. Meanwhile, glp-1 mutation caused resistance to toxicity of simulated microgravity. GLP-1 acted in germline cells to control toxicity of simulated microgravity. In germline cells, RNAi knockdown of glp-1 increased daf-16 expression. RNAi knockdown of daf-16 suppressed resistance to toxicity of simulated microgravity in glp-1 mutant. In simulated microgravity treated worms, germline RNAi knockdown of glp-1 decreased expressions of daf-28, ins-39, and ins-8 encoding insulin peptides, and resistance to simulated microgravity toxicity could be detected in daf-28(RNAi), ins-39(RNAi), and ins-8(RNAi) worms. In simulated microgravity treated worms, RNAi knockdown of daf-28, ins-39, or ins-8 in germline cells further increased expression and nucleus localization of transcriptional factor DAF-16 in intestinal cells. Therefore, the GLP-1-activated germline-intestine communication of insulin signaling is required for control of simulated microgravity toxicity in C. elegans.

Published
2021
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231. Response of G protein-coupled receptor CED-1 in germline to polystyrene nanoparticles inCaenorhabditis elegans

Author

Dayong Wang, Wenting Dong, Yunhan Yang, and Qiuli Wu

Subjects
0301 basic medicine, p38 mitogen-activated protein kinases, Bioengineering, 010501 environmental sciences, 01 natural sciences, Germline, 03 medical and health sciences, RNA interference, General Materials Science, Receptor, health care economics and organizations, Caenorhabditis elegans, 0105 earth and related environmental sciences, G protein-coupled receptor, biology, Chemistry, fungi, technology, industry, and agriculture, General Engineering, General Chemistry, biology.organism_classification, Atomic and Molecular Physics, and Optics, Cell biology, Insulin receptor, 030104 developmental biology, Toxicity, biology.protein
Abstract

The deposition of a certain amount of nanopolystyrene (NPS) can be observed in the gonad of Caenorhabditis elegans. However, we still know little about the response of germline towards NPS exposure. In the germline of C. elegans, NPS (1–1000 μg L−1) increased the expression levels of two G protein-coupled receptors (GPCRs), namely PAQR-2 and CED-1. Moreover, susceptibility to NPS toxicity was observed in ced-1(RNAi) worms, which suggested that the protective response of germline was mediated by GPCR CED-1. In the germline, five proteins (CED-10, VPS-34, SNX-1, RAB-7, and RAB-14) functioned as downstream targets of GPCR CED-1 in controlling NPS toxicity. Furthermore, these five targets in the germline regulated NPS toxicity by affecting the activities of p38 MAPK and insulin signaling pathways in intestinal cells. Therefore, we raised a GPCR CED-1-mediated signaling cascade in the germline in response to NPS exposure, which is helpful for understanding the molecular basis of the germline in response to NPS exposure.

Published
2021
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232. Photonics-Assisted Frequency Up/Down Conversion With Tunable OEO and Phase Shift

Author

Zhong Xin, Feng Yang, Zhiyu Chen, Dayong Wang, Zhou Tao, Hongbiao Zhang, Dengcai Yang, and Yunxin Wang

Subjects
Materials science, business.industry, Local oscillator, 02 engineering and technology, Signal, Atomic and Molecular Physics, and Optics, 020210 optoelectronics & photonics, Modulation, Phase noise, 0202 electrical engineering, electronic engineering, information engineering, Optoelectronics, business, Phase modulation, Frequency modulation, Quadrature amplitude modulation, Spectral purity
Abstract

A novel photonics-assisted method for frequency up/down-conversion based on an integrated dual-polarization dual-parallel Mach–Zehnder modulator (DP-DPMZM) with tunable optoelectronic oscillator (OEO) and phase shift is presented. The local oscillator (LO) signal with high spectral purity and low phase noise is generated by an OEO loop in one of the sub-DPMZMs. The frequency can be adjusted by an electrical bandpass filter (EBPF). The radio frequency (RF) signal is injected into another sub-DPMZM. The carrier-suppressed single-sideband (CS-SSB) modulation of both the LO and RF signals is achieved. The phase of the converted signal can be tuned by an integrated dual-channel phase modulator (DPM). Frequency up/down-conversion can be switched by tuning a single bias voltage of the DP-DPMZM. Multiple functions, including tunable LO signal generation, up/down-conversion and phase shifting, can be realized. Moreover, dispersion-induced power fading is well compensated due to CS-SSB modulation. In the experiments, the tunable LO signal from 5 to 18 GHz, with a sidemode suppression ratio as high as 46.1 dB and a phase noise level of −104.5 dBc/Hz @ 10 kHz at 10 GHz, is generated successfully. The spur suppression ratios of the up/down-converted signals are 32.6 dB and 35.6 dB, respectively. The up/down conversion performance for RF carrying 16 quadrature amplitude modulation (16-QAM) signal is also investigated. The phase shifting of dual-channel converted signals can be varied continuously and independently in the range of 0–360°, and the phase deviation is ±1.8°. The proposed compact link is characterized by function multiplexing and inherent dispersion compensation.

Published
2020
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233. A towed-type shallow high-resolution seismic detection system for coastal tidal flats and its application in Eastern China

Author

Kai Zhang, Kai Wang, Dayong Wang, Jinli Li, Hangyu Yue, Guangke Wang, Baowei Zhang, and Xiaojiang Wang

Subjects
Geophysics, 010504 meteorology & atmospheric sciences, Eastern china, High resolution, Geology, Management, Monitoring, Policy and Law, 010502 geochemistry & geophysics, 01 natural sciences, Industrial and Manufacturing Engineering, Seismology, 0105 earth and related environmental sciences
Abstract

Restricted by detective equipment and tidal influence seriously, coastal tidal flats are often treated as the transition belt of paralic zone in terms of seismic detection, causing low exploration degree and accuracy in these areas. What is worse, conventional shallow seismic method has a complex system and low acquisition efficiency, which cannot meet the requirements for high-efficiency acquisition in tidal flats. To solve these problems, a towed shallow seismic detection system is specially established for coastal tidal areas, mainly including electric spark source and towable ship-type geophone strings. After comparisons, some advantages of this method are obtained, such as high efficiency, low cost and reliability. Furthermore, its detective accuracy and depth can reach the meter level and more than 800 m, respectively. Then, a series of shallow seismic processing methods are improved for coastal tidal flats. Deconvolution and velocity analysis are emphatically introduced to multiple-wave attenuation. A short array of this towable detection can keep a far more effective wave from being cut off because of its small NMO stretch. Last but not least, the towable method in coastal tidal-flat zones can successfully identify the stratigraphic structure, interface, palaeo-channel, concealed active fault and submarine shallow gas in Jiangsu Coast, Eastern China, which has great practical results and significance for geological and environmental surveys, as well as scientific geo-hazard prevention and mitigation in these areas.

Published
2020
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234. Additive manufacturing of WC-Co hardmetals: a review

Author

Yankun Yang, Yingtao Tian, Dayong Wang, Daniel Wellmann, Liping Nie, and Chaoqun Zhang

Subjects
Toughness, Materials science, 020502 materials, Mechanical Engineering, Metallurgy, Fused filament fabrication, 02 engineering and technology, 021001 nanoscience & nanotechnology, Microstructure, Casting, Industrial and Manufacturing Engineering, Computer Science Applications, 0205 materials engineering, Machining, Control and Systems Engineering, Powder metallurgy, Selective laser melting, 0210 nano-technology, Software
Abstract

WC-Co hardmetals are widely used in wear-resistant parts, cutting tools, molds, and mining parts, owing to the combination of high hardness and high toughness. WC-Co hardmetal parts are usually produced by casting and powder metallurgy, which cannot manufacture parts with complex geometries and often require post-processing such as machining. Additive manufacturing (AM) technologies are able to fabricate parts with high geometric complexity and reduce post-processing. Therefore, additive manufacturing of WC-Co hardmetals has been widely studied in recent years. In this article, the current status of additive manufacturing of WC-Co hardmetals is reviewed. The advantages and disadvantages of different AM processes used for producing WC-Co parts, including selective laser melting (SLM), selective electron beam melting (SEBM), binder jet additive manufacturing (BJAM), 3D gel-printing (3DGP), and fused filament fabrication (FFF) are discussed. The studies on microstructures, defects, and mechanical properties of WC-Co parts manufactured by different AM processes are reviewed. Finally, the remaining challenges in additive manufacturing of WC-Co hardmetals are pointed out and suggestions on future research are discussed.

Published
2020
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235. Uncertainty and sensitivity analysis of relative permeability curves for the numerical simulation of CO 2 core flooding

Author

Zhanpeng Zheng, Dayong Wang, Qingsong Ma, Yongchen Song, and Pei Hu

Subjects
Capillary pressure, Environmental Engineering, Computer simulation, Estimation theory, Model selection, 02 engineering and technology, Mechanics, 010501 environmental sciences, Residual, 01 natural sciences, Permeability (earth sciences), 020401 chemical engineering, Environmental Chemistry, 0204 chemical engineering, Relative permeability, Saturation (chemistry), 0105 earth and related environmental sciences, Mathematics
Abstract

Various error sources exist in the specified relative permeability (kr) curves for numerical modeling of CO2/water core flooding process, including model selection, parameter estimation, and heterogeneity setting. In this study, we quantitatively investigate their effects on model predictions by a numerical sensitivity analysis. Numerical simulation results indicate: (1) The errors in residual gas saturation (Sgr) and residual liquid saturation (Slr) could significantly influence the estimation of the total volume (TPV) of injected CO2 when CO2/water displacement reaches a steady state. A change of Sgr or Slr by 0.1 can induce deviation in TPV up to 0.5 pore volume. (2) The change in Sgr could cause a bigger predictive deviation in local CO2 saturation (SCO2) than that in Slr. In the case of the same degree of change, the deviation of the former is almost twice as much as that of the latter. (3) The model predictions remain fairly consistent when utilizing either Corey's curve or Brooks–Corey curve, but become significantly different if changing to van Genuchten curve. In this case, the difference in TPV is greater than that caused by the errors in Sgr or Slr. The maximum deviation in the predicted local SCO2 exceeds 0.3, influencing the analysis of CO2 local trapping behavior. Comparatively, the local SCO2 buildup is only slight if van Genuchten curve is used, but obvious using Corey's curve. (4) kr heterogeneity only presents a small effect on the local SCO2 and could be reasonably ignored compared to the effects of the heterogeneity in capillary pressure and permeability. © 2020 Society of Chemical Industry and John Wiley & Sons, Ltd.

Published
2020
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236. Fast Depth and Inter Mode Prediction for Quality Scalable High Efficiency Video Coding

Author

Weisheng Li, Ce Zhu, Yu Sun, Frederic Dufaux, Dayong Wang, Chongqing University of Posts and Telecommunications, Department of Computer and Information Sciences [Alabama] (CIS), University of Alabama at Birmingham [ Birmingham] (UAB), University of Electronic Science and Technology of China (UESTC), Laboratoire des signaux et systèmes (L2S), and Université Paris-Sud - Paris 11 (UP11)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)

Subjects
Computer science, Gaussian, coding depth, 020206 networking & telecommunications, 02 engineering and technology, coding mode, Coding tree unit, Computer Science Applications, symbols.namesake, SHVC, [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, [INFO.INFO-TI]Computer Science [cs]/Image Processing [eess.IV], Signal Processing, Bit rate, 0202 electrical engineering, electronic engineering, information engineering, Media Technology, symbols, early termination, 020201 artificial intelligence & image processing, mode prediction, Electrical and Electronic Engineering, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, Encoder, Algorithm, Coding (social sciences)
Abstract

International audience; The scalable high efficiency video coding (SHVC) is an extension of high efficiency video coding (HEVC), which introduces multiple layers and inter-layer prediction, thus significantly increases the coding complexity on top of the already complicated HEVC encoder. In inter prediction for quality SHVC, in order to determine the best possible mode at each depth level, a coding tree unit can be recursively split into four depth levels, including merge mode, inter2Nx2N, inter2NxN, interNx2N, interNxN, in-ter2NxnU, inter2NxnD, internLx2N and internRx2N, intra modes and inter-layer reference (ILR) mode. This can obtain the highest coding efficiency, but also result in very high coding complexity. Therefore, it is crucial to improve coding speed while maintaining coding efficiency. In this research, we have proposed a new depth level and inter mode prediction algorithm for quality SHVC. First, the depth level candidates are predicted based on inter-layer correlation, spatial correlation and its correlation degree. Second, for a given depth candidate, we divide mode prediction into square and non-square mode predictions respectively. Third, in the square mode prediction, ILR and merge modes are predicted according to depth correlation, and early terminated whether residual distribution follows a Gaussian distribution. Moreover, ILR mode, merge mode and inter2Nx2N are early terminated based on significant differences in Rate Distortion (RD) costs. Fourth, if the early termination condition cannot be satisfied, non-square modes are further predicted based on significant differences in expected values of residual coefficients. Finally, inter-layer and spatial correlations are combined with residual distribution to examine whether to early terminate depth selection. Experimental results have demonstrated that, on average, the proposed algorithm can achieve a time saving of 71.14%, with a bit rate increase of 1.27%.

Published
2020
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237. Single-wall carbon nanotube promoted allylic homopolymerization for holographic patterning

Author

Xinping Zhang, Dayong Wang, He Ma, Jialing Jian, Lin Cao, and Jinxin Guo

Subjects
chemistry.chemical_classification, Allylic rearrangement, Materials science, chemistry.chemical_element, 02 engineering and technology, General Chemistry, Polymer, Carbon nanotube, 010402 general chemistry, 021001 nanoscience & nanotechnology, Diffraction efficiency, 01 natural sciences, 0104 chemical sciences, law.invention, chemistry.chemical_compound, Monomer, Photopolymer, chemistry, Polymerization, Chemical engineering, law, General Materials Science, 0210 nano-technology, Carbon
Abstract

This article interrogates the mechanism for the incorporation of single-wall carbon nanotubes in the photo-initiated thiol-ene polymerization process and its application in holographic patterning. We find that single-wall carbon nanotube is able to turn on the allylic homopolymerization, which is not involved in the conventional thiol-ene photopolymerization process because of the autoinhibition of allyl monomer. This also leads to an enhancement of conversion for both thiol and allyl monomers. For the first time, the ability of single-wall carbon nanotube that promotes an autoinhibition monomer to homopolymerize is revealed. By applying this new mechanism, a flexible single-wall carbon nanotube-polymer composite film for the use of holographic patterning is demonstrated. The effects of the incorporation of single-wall carbon nanotubes on refractive index modulation and mechanical properties of a volume grating recorded are examined. It is shown that a substantial increase in refractive index modulation and diffraction efficiency is realized by small loading of single-wall carbon nanotubes (0.0015 wt%). This validate the proposed mechanisms provide a simple way to control the photopolymerization and therefore to tailor polymers for optical application uses.

Published
2020
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238. Precision measurement of the W boson decay branching fractions in proton-proton collisions at s=13 TeV

Author

Mikko Voutilainen, Stefaan Tavernier, Jordan Nash, Francisco Garcia, Raghunath Pradhan, Gabriella Pugliese, Alberto Escalante del Valle, Praveen Chandra Tiwari, Mate Csanad, Kadir Saygin, Kenneth Bloom, Pietro Govoni, Maximilian Pérez Prada, Arie Bodek, Riccardo Salvatico, Mikhail Dubinin, Andrea Cardini, Chang-Seong Moon, Ted Kolberg, Guenakh Mitselmakher, Kun Shi, Caglar Zorbilmez, Lorenzo Viliani, Ankush Reddy Kanuganti, Wesley Smith, Mikael Myllymäki, Hesham El Faham, Walaa Elmetenawee, Erhan Gülmez, Giovanni Abbiendi, Fabrizio Palla, Valentina Sola, Matthias Schröder, Cristina Riccardi, Sami Lehti, Abanti Ranadhir Sahasransu, Joseph Reichert, Jussi Viinikainen, Badder Marzocchi, Luke Kreczko, Hugues Lattaud, FLAVIA CETORELLI, Georgios Konstantinos Krintiras, Samet Lezki, Stefano Belforte, Maria Savina, Reza Goldouzian, Márton Bartók, Daniele Fasanella, Erika Garutti, Louis Moureaux, Nadia Pastrone, Danyer Pérez Adán, Muhammad Ahmad, Konstantin Androsov, Toni Sculac, Arun Kumar, Andreas Pfeiffer, Jorge Berenguer Antequera, Giuseppe Della Ricca, Eduard De La Cruz Burelo, Joern Schwandt, Christopher Tully, Luigi Calligaris, Wael HAJ AHMAD (Vael HAJAHMAD), Jennifer Ott, Francisco Javier Cuevas Maestro, Steffen Albrecht, Pablo Matorras-Cuevas, Prabhat Ranjan Pujahari, Alessandra Cappati, Alexander Belyaev, Florian Bury, James Buchanan, Roman Kogler, Andrea Giammanco, Marco Toliman Lucchini, Guenther Dissertori, Francesca Cavallari, José María Hernández Calama, Antonello Pellecchia, Efe Yazgan, Nils Faltermann, Yuri Gershtein, Sinan Sagir, Tomas Lindén, Halil Saka, Luca Cadamuro, Florencia Canelli, Simone Pigazzini, Armando Bermudez Martinez, Dmitri Konstantinov, Ksenia Shchelina, Cesar Augusto Bernardes, Bingran Wang, Qiang Li, Nicolò Trevisani, Tapio Lampén, Md Naimuddin, Barry Blumenfeld, Leonid Levchuk, Claudio Grandi, Giovanni Petrucciani, Dayong Wang, Marco Zanetti, Cristina Botta, Danilo Meuser, Martti Raidal, John Conway, Jaime Leon Holgado, Paolo Giacomelli, Jay R. Dittmann, Yalcin Guler, Agni Bethani, Marcin Konecki, Franco Ligabue, Alexander Grohsjean, Lourdes Urda, Mahmoud Moussa Abdelkhalek Gadallah, Silvano Tosi, Martina Malberti, Merve Ince Lezki, Jochen Schieck, Leonardo Cristella, Ernesto Migliore, Pritam Kalbhor, Silvia Goy Lopez, Ashish Sharma, Tommaso Diotalevi, Nikolaos Manthos, Lisa Benato, Suman Chatterjee, Émilien Chapon, Stéphane PERRIES, JUAN ALCARAZ MAESTRE, Antonio Vilela Pereira, Álvaro Navarro-Tobar, Thong Q. Nguyen, Zhenbin Wu, Maria Clemencia Mora Herrera, Zhengyun You, Agostino De Iorio, Ilaria Vai, Gilvan Alves, Sandeep Bhowmik, Cristina Fernández Bedoya, Nabin Poudyal, Markus Seidel, Andre Sznajder, Ali Eren Simsek, Tamer Elkafrawy, Pedro Galli Mercadante, Kenyi Hurtado Anampa, Luca Giommi, Efe Yigitbasi, Andrea Massironi, Andrey Starodumov, Jose Ruiz, Mario Pelliccioni, Caroline Collard, Alexei Safonov, WILLIAM FORD, Junghwan Goh, Spandan Mondal, Jingyan Li, German Ruben Martinez, Walter Snoeys, Evgueni Tcherniaev, Matteo Presilla, Stephen Mrenna, Jeremy Andrea, Panja Luukka, Saranya Samik Ghosh, Rogelio Reyes-Almanza, Joachim Mnich, Sandor Lokos, Darin Acosta, Karl Ehatäht, Aurelijus Rinkevicius, Frank Geurts, Isabel Josa Mutuberria, Junquan Tao, Paul Kyberd, Ece ASILAR, David D'Enterria, Daniel Savoiu, Adish Vartak, Francesco Fienga, Jay Lawhorn, Arabella Martelli, Robert Cousins, Santeri Laurila, Jorma Tuominiemi, Andrey Popov, Jehad Mousa, Martin Grunewald, Tirso Alejandro Gomez Espinosa, Paolo Spagnolo, Nicholas Wardle, Redwan Habibullah, Robert Klanner, Frank Golf, Isidro González Caballero, Crisostomo Sciacca, Oscar Gonzalez Lopez, Tahys Janssen, Jeremi Niedziela, Robert Bainbridge, Elizabeth Starling, Andrea Rizzi, Javier Alberto Murillo Quijada, Klaus Rabbertz, Luigi (Gigi) Rolandi, Federica Legger, Andrew Ivanov, ANKITA MEHTA, Ioannis Papadopoulos, Greg Landsberg, Malte Backhaus, Aliakbar Ebrahimi, INSEOK YOON, Sara Fiorendi, ANDREA PICCINELLI, Dmitry Kirpichnikov, Jennifer Ngadiuba, Tamas Almos Vami, Ivan Heredia de la Cruz, Maciej Malawski, Vuko Brigljević, Thomas McCauley, Vittorio Raoul Tavolaro, Pablo Martinez Ruiz del Arbol, Davide Fiorina, Kaur Sandeep, Reddy Pratap Gandrajula, Luca Malgeri, Leszek Grzanka, Peter Elmer, Lea Caminada, Kenneth Osterberg, Emil Sørensen Bols, Leandar Litov, Lata Panwar, Zhicai Zhang, Anton Stepennov, Arnd Meyer, Tatyana Dimova, Christophe Ochando, Gabriel Ramirez Sanchez, Alberto Ruiz Jimeno, J B Singh, Johannes Lange, Peter Wittich, Maria Cruz Fouz Iglesias, Korbinian Schweiger, Gaetano Marco Dallavalle, Pietro Faccioli, Rafael Eduardo Sosa Ricardo, Avi Yagil, Muhammad Gul, Jaana Heikkilä, Arne Christoph Reimers, Michele Arneodo, José Flix Molina, Javier Fernandez Menendez, Alexander Tapper, Valeria D'Amante, Sandra S. Padula, George Alverson, Lev Dudko, Juan Pablo Fernández Ramos, Karl Ecklund, Martin Delcourt, Salvatore Costa, Yacine Haddad, Paolo Meridiani, Ignacio Redondo, Marco Monteno, Gautier Hamel de Monchenault, Salvatore Rappoccio, Gerrit Van Onsem, Bora Akgun, Thomas Reis, Anna Colaleo, Marco CUFFIANI, Torben Lange, Lutz Feld, Varun Sharma, Gabriella Pásztor, Nicolas Stylianou, Sung-Won Lee, Joel Goldstein, Daniel Diaz, Paolo Azzurri, Oleg Filatov, Welathantri Dharmaratna, Benedikt Vormwald, Davide Zuolo, Ram Krishna Sharma, Ian Watson, Javier Mauricio Duarte, Vilius Cepaitis, Andreas Hinzmann, Nikkie Deelen, Matthias Kasemann, Manfred Paulini, Paolo Dini, Andre Frankenthal, Kevin Lannon, Mithat Kaya, Myriam Schönenberger, Florian Beaudette, Barbara Alvarez Gonzalez, Nuno Leonardo, Maxim Titov, Laurent Forthomme, Jose Enrique Palencia Cortezon, Rainer Wallny, Pietro Vischia, Schoefbeck Robert, Thea Aarrestad, Pieter David, Liuyao Zhang, Tae Jeong Kim, Marco Pieri, Sunil Manohar Dogra, Shabnam Jabeen, Guido Emilio Tonelli, Mar Capeans, Davide Di Croce, Ugur Kiminsu, J.F. Benitez, Luiz Mundim, Jason Lee, Jorgen D'Hondt, Maria Cepeda, Pallabi Das, Ksenia De Leo, Deborah Pinna, Morgan Lethuillier, Soureek Mitra, Bruno Lenzi, Sergio Novaes, Antonio Delgado Peris, Amina Zghiche, Pieter Everaerts, Gurpreet Singh Chahal, Hannu Siikonen, Mohammed Attia Mahmoud, André David Tinoco Mendes, Olga Evdokimov, Pierluigi Bortignon, Shubhanshu Chauhan, Simone Gennai, Ahmad Lotfy Abdelfattah Ahmad, Freya Blekman, Furkan Dolek, Federica Maria Simone, Raffaele Gerosa, Benjamin Krikler, Geoffrey Hall, Eija Tuominen, Marko Dragicevic, Antonio Perez-Calero Yzquierdo, Nadezda Chernyavskaya, Viola Sordini, Mykhailo Dalchenko, Joona Juhani Havukainen, Biagio Rossi, Ibrahim Soner Zorbakir, Pavel Parygin, Sandra Consuegra Rodriguez, Roberto Covarelli, Chiara Amendola, Christophorus Grab, Mojtaba Mohammadi Najafabadi, Henning Flaecher, Dilson De Jesus Damiao, Arthur Moraes, Lucas Taylor, Graham Wilson, Rui Xiao, Minsuk Kim, Francisco Matorras, Alberto Sanchez-Hernandez, Tobias Robert Jakob Kramer, Marino Missiroli, Jan-Frederik Schulte, Fotios Ptochos, Shudhashil Bharthuar, Justin Williams, Helen Heath, Wolfgang Waltenberger, Henning Kirschenmann, Hannes Jung, Emrah Tiras, Camilo Carrillo Montoya, Alberto Zucchetta, Ralf Ulrich, Calandri Alessandro, Tahereh Sadat Niknejad, Guillelmo Gomez-Ceballos, Felipe Araujo, Kadri Ozdemir, Patrizia Azzi, Muhammad Alibordi, Vladimir Gavrilov, Johannes Haller, Kati Lassila-Perini, Abhijith Gandrakota, Konstantinos Theofilatos, Gouranga Kole, Eliza Melo da Costa, Andrea Davide Benaglia, Sebastian Wuchterl, Jesus Puerta Pelayo, Laura Martikainen, Ram Krishna Dewanjee, Christophe Delaere, Simon Regnard, Aaron Dominguez, Emanuele Usai, Matthew Herndon, Kenichi Hatakeyama, LUCA GUZZI, Alberto Belloni, Harrison Bertrand Prosper, Federico Siviero, Mariana Shopova, Mauro Donega, Abideh Jafari, Antonio Cassese, Federico De Guio, UTTIYA SARKAR, Aashaq Shah, Oliver Gutsche, Claudio Caputo, Mauro Emanuele Dinardo, Elisabetta Manca, Amedeo Staiano, Soumya Mukherjee, Thiago Rafael Fernandez Perez Tomei, Sudhir Malik, Clemens Lange, and Bożena Boimska

Published
2022
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239. Neh1 and Neh3 domains of nuclear factor erythroid 2-related factor 2 mediate its binding to NAD-dependent protein deacetylase sirtuin-6

Author

Wanmeng Fu, Jinli Pei, Zhengpan Xiao, Yan Sun, Zhuandan Zhang, Hao Wu, Shuangshuang Wei, Yechun Pei, and Dayong Wang

Subjects
respiratory system
Abstract

Oxidative stress is one of the causes of aging and other diseases. Nrf2 is the main transcription factor regulating antioxidant gene expression. In recent years, it has been found that inhibiting Nrf2 activity or increasing oxidative pressure can replicate premature aging defects, and reactivating Nrf2 activity can reverse nuclear aging defects and restore cell vitality. SIRT6 is one of the few proteins that can regulate life span and aging at the same time. SIRT6 gene deficient mice show degenerative changes similar to human premature aging 3 weeks after birth and eventually die. SIRT6 deficient cells show the characteristics of accelerated aging, while the deletion of SIRT6 in human cells does not directly lead to the damage of genetic material in the nucleus and genomic instability, but significantly reduces the antioxidant capacity of cells and causes the accumulation of intracellular reactive oxygen species and DNA oxidation products. At present, the interaction between Nrf2 and SIRT6 protein and its mechanism are not clear. In this study, yeast two-hybrid and tag pulldown methods were used to analyze the protein interaction domain between Nrf2 and SIRT6. The experiment found that SIRT6 directly interacts with Nrf2, SIRT6 Interacts with the Neh1 and Neh3 domains of Nrf2.

Published
2022
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240. Sudden Sensorineural Hearing Loss as the Initial Symptom in Acoustic Neuroma Patients

Author

Mengtao Song, Dayong Wang, Jin Li, Guohui Chen, Xiaolong Zhang, Hongyang Wang, and Qiuju Wang

Subjects
otorhinolaryngologic diseases
Abstract

Previous studies have shown that patients with acoustic neuroma (AN) sometimes present with sudden sensorineural hearing loss (SSNHL) as an initial symptom. The purpose of this research was to investigate the clinical characteristics, diagnosis and treatment of AN in patients diagnosed as SSNHL initially. A total of 10 patients presented with SSNHL as the initial symptom and diagnosed as AN by magnetic resonance imaging (MRI) finally were enrolled in this study. Patient demographics, associated complaints (mostly tinnitus and vertigo), severity of hearing loss, audiogram configurations, auditory brainstem response (ABR) and MRI examination were reviewed and analyzed. Treatment outcome and management protocols were also included in this study. These patients exhibited varying severity of hearing loss and a variety of audiogram configurations. All patients showed an abnormal ABR. According to the Koos grading standard, there were 5 grade I (intracanalicular) tumors, 3 grade II tumors and 2 grade III tumors. The treatment outcome revealed that 2 patients exhibited recovery of the average hearing of impaired frequency by more than 15 dB, and 6 patients showed no recovery. Four patients were referred to undergo surgical treatment after being diagnosed with AN, 1 patient accepted stereotactic radiation therapy, and the remaining 5 patients were taken “waiting and scan” strategy. The findings of this study show that hearing recovery after corticosteroid treatment for SSNHL does not exclude the presence of AN and all patients diagnosed as SSNHL initially should undergo MRI and ABR to prevent misdiagnosis and delays in potential treatment.

Published
2022
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241. Alteration in Wnt signaling mediates induction of transgenerational toxicity of polystyrene nanoplastics in C. elegans

Author

Ruoran Xu, Xin Hua, Qi Rui, and Dayong Wang

Subjects
Materials Science (miscellaneous), Public Health, Environmental and Occupational Health, Safety, Risk, Reliability and Quality, Safety Research
Abstract

Polystyrene nanoparticles (PS-NPs) have a potential toxicity on offspring after the exposure. However, the molecular basis for PS-NP in inducing transgenerational toxicity remains largely unknown. In this study, the role and the underlying mechanism of germline Wnt signaling in regulating transgenerational toxicity of PS-NPs were determined using an in vivo animal model of Caenorhabditis elegans. Exposure to PS-NP (1-100 μg/L) increased expression of Wnt ligand LIN-44 and decreased expression of Wnt receptor MIG-1. After the exposure, the transgenerational PS-NP toxicity on locomotion behavior and brood size were inhibited in lin-44(RNAi) nematodes, while enhanced in mig-1(RNAi) nematodes. The resistance to transgenerational PS-NP toxicity induced by RNAi of lin-44 in P0 generation (P0-G) was inhibited by RNAi of mig-1 in F1-G. In addition, after PS-NP exposure, germline RNAi of lin-44 at P0-G could increase the mig-1 expression in F1-G. Exposure to PS-NP (1-100 μg/L) further decreased expressions of Dishevelled proteins of DSH-1/2, increased APC complex component APR-1, and decreased expression of BAR-1/β-catenin. Meanwhile, transgenerational PS-NP toxicity was enhanced by RNAi of dsh-1, dsh-2, or bar-1 and inhibited by RNAi of apr-1, suggesting that the DSH-1/2-APR-1-BAR-1 signaling cascade acted downstream of Wnt receptor MIG-1 to control transgenerational PS-NP toxicity. Moreover, BAR-1 acted upstream of DVE-1 to activate mitochondrial unfolded protein response (mt UPR) against the transgenerational PS-NP toxicity. Our data highlights the potential link between alteration in germline Wnt signaling and induction of transgenerational nanoplastic toxicity in organisms.

Published
2022

242. Multi-walled carbon nanotubes induce transgenerational toxicity associated with activation of germline long non-coding RNA linc-7 in C.elegans

Author

Yingyue Zhao, Ruoran Xu, Xin Hua, Qi Rui, and Dayong Wang

Subjects
History, Environmental Engineering, Polymers and Plastics, Nanotubes, Carbon, Health, Toxicology and Mutagenesis, Public Health, Environmental and Occupational Health, General Medicine, General Chemistry, Pollution, Industrial and Manufacturing Engineering, Germ Cells, Environmental Chemistry, Animals, RNA, Long Noncoding, Business and International Management, Caenorhabditis elegans, Caenorhabditis elegans Proteins
Abstract

With the increase in application, multi-walled carbon nanotubes (MWCNTs) are potentially bioavailable to environmental organisms. However, the potential transgenerational effect of MWCNTs and underlying mechanisms remains still unclear. Here, we examined transgenerational MWCNT toxicity and the underlying mechanism mediated by germline long non-coding RNAs (lncRNAs) in Caenorhabditis elegans. Exposure to 0.1-10 μg/L MWCNT caused transgenerational toxicity reflected by endpoints of brood size and locomotion behavior. Meanwhile, among germline lncRNAs, expression of 5 lncRNAs were dysregulated by MWCNT exposure. Among these 5 dysregulated lncRNAs, only germline RNAi of linc-7 affected MWCNT toxicity. Increase in germline linc-7 expression was observed transgenerationally, and transgenerational MWCNT toxicity was prevented in linc-7(RNAi) nematodes. Moreover, germline linc-7 controlled transgenerational MWCNT toxicity by activating downstream DAF-12, a transcriptional factor. Therefore, our data indicated the association between induction of transgenerational MWCNT toxicity and increase in germline linc-7 expression in organisms.

Published
2022

244. Search for heavy resonances decaying to WW , WZ , or WH boson pairs in a final state consisting of a lepton and a large-radius jet in proton-proton collisions at s=13 TeV

Author

Viacheslav Bunichev, Mikko Voutilainen, Stefaan Tavernier, Jordan Nash, Francisco Garcia, Raghunath Pradhan, Gabriella Pugliese, Altan Cakir, Alberto Escalante del Valle, Mate Csanad, Kadir Saygin, Kenneth Bloom, Pietro Govoni, Maximilian Pérez Prada, Arie Bodek, Mikhail Dubinin, Valentina Mariani, Chang-Seong Moon, Ted Kolberg, Guenakh Mitselmakher, Diana Seitova, Kun Shi, Dhanush Anil Hangal, Caglar Zorbilmez, Lorenzo Viliani, Ankush Reddy Kanuganti, Wesley Smith, Mikael Myllymäki, Hesham El Faham, Walaa Elmetenawee, Erhan Gülmez, Giovanni Abbiendi, Fabrizio Palla, Valentina Sola, Matthias Schröder, Cristina Riccardi, Sami Lehti, Abanti Ranadhir Sahasransu, Jussi Viinikainen, Badder Marzocchi, Luke Kreczko, FLAVIA CETORELLI, Georgios Konstantinos Krintiras, Samet Lezki, Stefano Belforte, Maria Savina, Márton Bartók, Daniele Fasanella, Erika Garutti, Nadia Pastrone, Konstantin Androsov, Andreas Pfeiffer, Giuseppe Della Ricca, Eduard De La Cruz Burelo, Lucia Silvestris, Joern Schwandt, Christopher Tully, Luigi Calligaris, Wael HAJ AHMAD (Vael HAJAHMAD), Diego Ciangottini, Jennifer Ott, Francisco Javier Cuevas Maestro, Prabhat Ranjan Pujahari, Alessandra Cappati, Alexander Belyaev, Andrea Giammanco, Marco Toliman Lucchini, Guenther Dissertori, Francesca Cavallari, José María Hernández Calama, Efe Yazgan, Nils Faltermann, Yuri Gershtein, Sinan Sagir, Tomas Lindén, Halil Saka, Luca Cadamuro, Florencia Canelli, Simone Pigazzini, Armando Bermudez Martinez, Cesar Augusto Bernardes, Qiang Li, Nicolò Trevisani, Tapio Lampén, Md Naimuddin, Barry Blumenfeld, Gustavo Gil Da Silveira, Leonid Levchuk, Claudio Grandi, Giovanni Petrucciani, Dayong Wang, Marco Zanetti, Cristina Botta, Danilo Meuser, Martti Raidal, John Conway, Paolo Giacomelli, Agni Bethani, Marcin Konecki, Franco Ligabue, Alexander Grohsjean, Silvano Tosi, Martina Malberti, Merve Ince Lezki, Jochen Schieck, Leonardo Cristella, Ernesto Migliore, Tommaso Diotalevi, Nikolaos Manthos, Lisa Benato, Salvatore Buontempo, Émilien Chapon, Stéphane PERRIES, JUAN ALCARAZ MAESTRE, Antonio Vilela Pereira, Thong Q. Nguyen, Zhenbin Wu, Maria Clemencia Mora Herrera, Zhengyun You, Agostino De Iorio, Ilaria Vai, Gilvan Alves, Sandeep Bhowmik, Cristina Fernández Bedoya, Nabin Poudyal, Markus Seidel, Andre Sznajder, Ali Eren Simsek, Tamer Elkafrawy, Pedro Galli Mercadante, Kenyi Hurtado Anampa, Luca Giommi, Andrea Massironi, Jose Ruiz, Mario Pelliccioni, Caroline Collard, Alexei Safonov, WILLIAM FORD, Junghwan Goh, Spandan Mondal, German Ruben Martinez, Walter Snoeys, Evgueni Tcherniaev, Stephen Mrenna, Jeremy Andrea, Panja Luukka, Ashraf Mohamed, Saranya Samik Ghosh, Chiara Aimè, Joachim Mnich, Fonseca de Souza Sandro, Karl Ehatäht, Aurelijus Rinkevicius, Frank Geurts, Isabel Josa Mutuberria, Junquan Tao, Paul Kyberd, Ece ASILAR, David D'Enterria, Adish Vartak, Francesco Fienga, Jay Lawhorn, Mapse Barroso Ferreira, Arabella Martelli, Robert Cousins, Santeri Laurila, Jorma Tuominiemi, Andrey Popov, Stefano Ragazzi, Jehad Mousa, Martin Grunewald, Tirso Alejandro Gomez Espinosa, Paolo Spagnolo, Nicholas Wardle, Redwan Habibullah, Robert Klanner, Frank Golf, Isidro González Caballero, Crisostomo Sciacca, Oscar Gonzalez Lopez, Tahys Janssen, Jeremi Niedziela, Robert Bainbridge, Elizabeth Starling, Andrea Rizzi, Javier Alberto Murillo Quijada, Klaus Rabbertz, Luigi (Gigi) Rolandi, Federica Legger, Andrew Ivanov, ANKITA MEHTA, Ioannis Papadopoulos, Greg Landsberg, Malte Backhaus, Aliakbar Ebrahimi, INSEOK YOON, Sara Fiorendi, Jennifer Ngadiuba, Tamas Almos Vami, Ivan Heredia de la Cruz, Andrea Venturi, Maciej Malawski, Vuko Brigljević, Thomas McCauley, Vittorio Raoul Tavolaro, Pablo Martinez Ruiz del Arbol, Ulascan Sarica, Reddy Pratap Gandrajula, Luca Malgeri, Francesco Moscatelli, Leszek Grzanka, Peter Elmer, Lea Caminada, Kenneth Osterberg, Emil Sørensen Bols, Leandar Litov, Zhicai Zhang, Anton Stepennov, Arnd Meyer, Tatyana Dimova, Gabriel Ramirez Sanchez, Alberto Ruiz Jimeno, Johannes Lange, Peter Wittich, Maria Cruz Fouz Iglesias, Ivan Vila, Korbinian Schweiger, Gaetano Marco Dallavalle, Pietro Faccioli, Rafael Eduardo Sosa Ricardo, Avi Yagil, Muhammad Gul, Jaana Heikkilä, Arne Christoph Reimers, Michele Arneodo, José Flix Molina, Javier Fernandez Menendez, Alexander Tapper, Sandra S. Padula, George Alverson, Lev Dudko, Juan Pablo Fernández Ramos, Karl Ecklund, Martin Delcourt, Salvatore Costa, Yacine Haddad, Paolo Meridiani, Ignacio Redondo, Marco Monteno, Gautier Hamel de Monchenault, Salvatore Rappoccio, Gerrit Van Onsem, Thomas Reis, Anna Colaleo, Marco CUFFIANI, Lutz Feld, Varun Sharma, Gabriella Pásztor, Sung-Won Lee, Joel Goldstein, Paolo Azzurri, Sergio Lo Meo, Welathantri Dharmaratna, Benedikt Vormwald, Davide Zuolo, Ram Krishna Sharma, Ian Watson, Javier Mauricio Duarte, Andreas Hinzmann, Matthias Kasemann, Manfred Paulini, Paolo Dini, Andre Frankenthal, Kevin Lannon, Mithat Kaya, Myriam Schönenberger, Florian Beaudette, Barbara Alvarez Gonzalez, Nuno Leonardo, Maxim Titov, Laurent Forthomme, Jose Enrique Palencia Cortezon, Rainer Wallny, Pietro Vischia, Schoefbeck Robert, Kevin Mota Amarilo, Pieter David, Liuyao Zhang, Tae Jeong Kim, Marco Pieri, Sunil Manohar Dogra, Shabnam Jabeen, Guido Emilio Tonelli, Davide Di Croce, Upul Sonnadara, Ugur Kiminsu, J.F. Benitez, Luiz Mundim, Jason Lee, Jorgen D'Hondt, Maria Cepeda, Deborah Pinna, Morgan Lethuillier, Soureek Mitra, Sergio Novaes, Antonio Delgado Peris, Amina Zghiche, Pieter Everaerts, Hannu Siikonen, Mohammed Attia Mahmoud, André David Tinoco Mendes, Olga Evdokimov, Pierluigi Bortignon, Shubhanshu Chauhan, Simone Gennai, Ahmad Lotfy Abdelfattah Ahmad, Freya Blekman, Umberto Dosselli, Federica Maria Simone, Raffaele Gerosa, Benjamin Krikler, Geoffrey Hall, Eija Tuominen, Marko Dragicevic, Antonio Perez-Calero Yzquierdo, Viola Sordini, Mykhailo Dalchenko, Joona Juhani Havukainen, Biagio Rossi, Ibrahim Soner Zorbakir, Pavel Parygin, Sandra Consuegra Rodriguez, Roberto Covarelli, Chiara Amendola, Christophorus Grab, Mojtaba Mohammadi Najafabadi, Henning Flaecher, Dilson De Jesus Damiao, Arthur Moraes, Lucas Taylor, Graham Wilson, Minsuk Kim, Francisco Matorras, Alberto Sanchez-Hernandez, Tobias Robert Jakob Kramer, Marino Missiroli, Jan-Frederik Schulte, Fotios Ptochos, Shudhashil Bharthuar, Helen Heath, Wolfgang Waltenberger, Henning Kirschenmann, Alberto Zucchetta, Ralf Ulrich, Calandri Alessandro, Guillelmo Gomez-Ceballos, Kadri Ozdemir, Patrizia Azzi, Nikola Godinovic, Muhammad Alibordi, Vladimir Gavrilov, Johannes Haller, Gouranga Kole, Eliza Melo da Costa, Andrea Davide Benaglia, Jesus Puerta Pelayo, Laura Martikainen, Ram Krishna Dewanjee, Christophe Delaere, Simon Regnard, Aaron Dominguez, Emanuele Usai, Matthew Herndon, Alberto Belloni, Harrison Bertrand Prosper, Federico Siviero, Mariana Shopova, Mauro Donega, Abideh Jafari, Antonio Cassese, Federico De Guio, Aashaq Shah, Oliver Gutsche, Claudio Caputo, Mauro Emanuele Dinardo, Elisabetta Manca, Amedeo Staiano, Thiago Rafael Fernandez Perez Tomei, Sudhir Malik, Clemens Lange, and Bożena Boimska

Published
2022
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245. Measurement of the Inclusive and Differential Higgs Boson Production Cross Sections in the Decay Mode to a Pair of τ Leptons in pp Collisions at s=13 TeV

Author

Viacheslav Bunichev, Mikko Voutilainen, Stefaan Tavernier, Jordan Nash, Francisco Garcia, Raghunath Pradhan, Gabriella Pugliese, Altan Cakir, Alberto Escalante del Valle, Mate Csanad, Kadir Saygin, Kenneth Bloom, Pietro Govoni, Maximilian Pérez Prada, Arie Bodek, Mikhail Dubinin, Valentina Mariani, Chang-Seong Moon, Ted Kolberg, Guenakh Mitselmakher, Diana Seitova, Kun Shi, Dhanush Anil Hangal, Caglar Zorbilmez, Lorenzo Viliani, Ankush Reddy Kanuganti, Wesley Smith, Mikael Myllymäki, Hesham El Faham, Walaa Elmetenawee, Erhan Gülmez, Giovanni Abbiendi, Fabrizio Palla, Valentina Sola, Matthias Schröder, Cristina Riccardi, Sami Lehti, Abanti Ranadhir Sahasransu, Jussi Viinikainen, Badder Marzocchi, Luke Kreczko, Sebastian Brommer, FLAVIA CETORELLI, Georgios Konstantinos Krintiras, Samet Lezki, Stefano Belforte, Maria Savina, Márton Bartók, Daniele Fasanella, Erika Garutti, Shalini Thakur, Nadia Pastrone, Konstantin Androsov, Andreas Pfeiffer, Giuseppe Della Ricca, Eduard De La Cruz Burelo, Lucia Silvestris, Joern Schwandt, Christopher Tully, Luigi Calligaris, Wael HAJ AHMAD (Vael HAJAHMAD), Diego Ciangottini, Jennifer Ott, Francisco Javier Cuevas Maestro, Prabhat Ranjan Pujahari, Alessandra Cappati, Alexander Belyaev, Andrea Giammanco, Marco Toliman Lucchini, Guenther Dissertori, Francesca Cavallari, José María Hernández Calama, Efe Yazgan, Nils Faltermann, Yuri Gershtein, Sinan Sagir, Tomas Lindén, Halil Saka, Luca Cadamuro, Florencia Canelli, Simone Pigazzini, Armando Bermudez Martinez, Cesar Augusto Bernardes, Qiang Li, Nicolò Trevisani, Tapio Lampén, Md Naimuddin, Barry Blumenfeld, Gustavo Gil Da Silveira, Leonid Levchuk, Claudio Grandi, Giovanni Petrucciani, Dayong Wang, Marco Zanetti, Cristina Botta, Danilo Meuser, Martti Raidal, John Conway, Paolo Giacomelli, Agni Bethani, Marcin Konecki, Franco Ligabue, Alexander Grohsjean, Silvano Tosi, Martina Malberti, Merve Ince Lezki, Jochen Schieck, Leonardo Cristella, Ernesto Migliore, Tommaso Diotalevi, Nikolaos Manthos, Lisa Benato, Salvatore Buontempo, Émilien Chapon, Stéphane PERRIES, JUAN ALCARAZ MAESTRE, Antonio Vilela Pereira, Thong Q. Nguyen, Zhenbin Wu, Maria Clemencia Mora Herrera, Zhengyun You, Agostino De Iorio, Ilaria Vai, Gilvan Alves, Sandeep Bhowmik, Cristina Fernández Bedoya, Nabin Poudyal, Markus Seidel, Andre Sznajder, Ali Eren Simsek, Tamer Elkafrawy, Pedro Galli Mercadante, Kenyi Hurtado Anampa, Luca Giommi, Andrea Massironi, Jose Ruiz, Mario Pelliccioni, Caroline Collard, Alexei Safonov, WILLIAM FORD, Junghwan Goh, Spandan Mondal, German Ruben Martinez, Walter Snoeys, Evgueni Tcherniaev, Stephen Mrenna, Jeremy Andrea, Panja Luukka, Ashraf Mohamed, Saranya Samik Ghosh, Chiara Aimè, Joachim Mnich, Fonseca de Souza Sandro, Karl Ehatäht, Aurelijus Rinkevicius, Frank Geurts, Isabel Josa Mutuberria, Junquan Tao, Paul Kyberd, Ece ASILAR, David D'Enterria, Sergey Polikarpov, Adish Vartak, Francesco Fienga, Jay Lawhorn, Mapse Barroso Ferreira, Arabella Martelli, Robert Cousins, Santeri Laurila, Jorma Tuominiemi, Andrey Popov, Stefano Ragazzi, Jehad Mousa, Martin Grunewald, Tirso Alejandro Gomez Espinosa, Paolo Spagnolo, Nicholas Wardle, Redwan Habibullah, Robert Klanner, Frank Golf, Isidro González Caballero, Crisostomo Sciacca, Oscar Gonzalez Lopez, Tahys Janssen, Jeremi Niedziela, Robert Bainbridge, Elizabeth Starling, Andrea Rizzi, Javier Alberto Murillo Quijada, Klaus Rabbertz, Luigi (Gigi) Rolandi, Federica Legger, Andrew Ivanov, ANKITA MEHTA, Ioannis Papadopoulos, Greg Landsberg, Malte Backhaus, Aliakbar Ebrahimi, INSEOK YOON, Sara Fiorendi, Jennifer Ngadiuba, Tamas Almos Vami, Ivan Heredia de la Cruz, Andrea Venturi, Maciej Malawski, Vuko Brigljević, Thomas McCauley, Vittorio Raoul Tavolaro, Pablo Martinez Ruiz del Arbol, Ulascan Sarica, Reddy Pratap Gandrajula, Luca Malgeri, Francesco Moscatelli, Leszek Grzanka, Peter Elmer, Lea Caminada, Kenneth Osterberg, Emil Sørensen Bols, Leandar Litov, Zhicai Zhang, Anton Stepennov, Arnd Meyer, Tatyana Dimova, Gabriel Ramirez Sanchez, Alberto Ruiz Jimeno, Johannes Lange, Peter Wittich, Maria Cruz Fouz Iglesias, Ivan Vila, Patrizia Barria, Korbinian Schweiger, Gaetano Marco Dallavalle, Pietro Faccioli, Rafael Eduardo Sosa Ricardo, Avi Yagil, Muhammad Gul, Jaana Heikkilä, Arne Christoph Reimers, Michele Arneodo, José Flix Molina, Javier Fernandez Menendez, Alexander Tapper, Sandra S. Padula, George Alverson, Lev Dudko, Juan Pablo Fernández Ramos, Karl Ecklund, Martin Delcourt, Salvatore Costa, Yacine Haddad, Paolo Meridiani, Ignacio Redondo, Marco Monteno, Gautier Hamel de Monchenault, Salvatore Rappoccio, Gerrit Van Onsem, Thomas Reis, Anna Colaleo, Marco CUFFIANI, Lutz Feld, Varun Sharma, Gabriella Pásztor, Sung-Won Lee, Joel Goldstein, Paolo Azzurri, Welathantri Dharmaratna, Davide Zuolo, Ram Krishna Sharma, Ian Watson, Javier Mauricio Duarte, Andreas Hinzmann, Matthias Kasemann, Manfred Paulini, Paolo Dini, Andre Frankenthal, Kevin Lannon, Mithat Kaya, Florian Beaudette, Barbara Alvarez Gonzalez, Nuno Leonardo, Maxim Titov, Laurent Forthomme, Jose Enrique Palencia Cortezon, Rainer Wallny, Pietro Vischia, Schoefbeck Robert, Sheng Luo, Kevin Mota Amarilo, Gaia Grosso, Pieter David, Liuyao Zhang, Tae Jeong Kim, Marco Pieri, Alain Albert, Sunil Manohar Dogra, Shabnam Jabeen, Guido Emilio Tonelli, Davide Di Croce, Upul Sonnadara, Ugur Kiminsu, J.F. Benitez, Luiz Mundim, Jason Lee, Jorgen D'Hondt, Maria Cepeda, Deborah Pinna, Morgan Lethuillier, Soureek Mitra, Sergio Novaes, Antonio Delgado Peris, Amina Zghiche, Pieter Everaerts, Hannu Siikonen, Mohammed Attia Mahmoud, André David Tinoco Mendes, Olga Evdokimov, Pierluigi Bortignon, Shubhanshu Chauhan, Carlos Perez Dengra, Simone Gennai, Ahmad Lotfy Abdelfattah Ahmad, Freya Blekman, Umberto Dosselli, Federica Maria Simone, Raffaele Gerosa, Benjamin Krikler, Geoffrey Hall, Eija Tuominen, Marko Dragicevic, Antonio Perez-Calero Yzquierdo, Viola Sordini, Mykhailo Dalchenko, Joona Juhani Havukainen, Biagio Rossi, Ibrahim Soner Zorbakir, Pavel Parygin, Sandra Consuegra Rodriguez, Roberto Covarelli, Chiara Amendola, Christophorus Grab, Mojtaba Mohammadi Najafabadi, Henning Flaecher, Dilson De Jesus Damiao, Arthur Moraes, Lucas Taylor, Graham Wilson, Minsuk Kim, Francisco Matorras, Alberto Sanchez-Hernandez, Tobias Robert Jakob Kramer, Marino Missiroli, Jan-Frederik Schulte, Fotios Ptochos, Shudhashil Bharthuar, Helen Heath, Wolfgang Waltenberger, Henning Kirschenmann, Alberto Zucchetta, Ralf Ulrich, Calandri Alessandro, Guillelmo Gomez-Ceballos, Kadri Ozdemir, Patrizia Azzi, Nikola Godinovic, Muhammad Alibordi, Vladimir Gavrilov, Johannes Haller, Gouranga Kole, Eliza Melo da Costa, Andrea Davide Benaglia, Jesus Puerta Pelayo, Laura Martikainen, Ram Krishna Dewanjee, Christophe Delaere, Simon Regnard, Aaron Dominguez, Emanuele Usai, Matthew Herndon, Alberto Belloni, Harrison Bertrand Prosper, Federico Siviero, Mariana Shopova, Mauro Donega, Abideh Jafari, Antonio Cassese, Federico De Guio, Aashaq Shah, Oliver Gutsche, Claudio Caputo, Mauro Emanuele Dinardo, Elisabetta Manca, Amedeo Staiano, Thiago Rafael Fernandez Perez Tomei, Sudhir Malik, Clemens Lange, and Bożena Boimska

Subjects
General Physics and Astronomy
Published
2022
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248. Long-term exposure to tire-derived 6-PPD quinone causes intestinal toxicity by affecting functional state of intestinal barrier in Caenorhabditis elegans

Author

Xin, Hua, Xiao, Feng, Geyu, Liang, Jie, Chao, and Dayong, Wang

Subjects
Environmental Engineering, Environmental Chemistry, Pollution, Waste Management and Disposal
Abstract

2-((4-Methylpentan-2-yl)amino)-5-(phenylamino)cyclohexa-2,5-diene-1,4-dione (6-PPDQ) is the ozonation product of 6-PPD, a commonly used tire preservative. Although the 6-PPDQ has been frequently detected in different environmental ecosystems, its long-term effects on organisms remain still largely unknown. We here used Caenorhabditis elegans as an experimental animal to investigate the toxic effect of prolonged exposure to 6-PPDQ (0.1-100 μg/L). After the exposure, we found that 100 μg/L 6-PPDQ caused the lethality. We further selected concentrations of 0.1-10 μg/L to examine the possible intestinal toxicity induced by 6-PPDQ. Although 0.1-10 μg/L 6-PPDQ could not influence intestinal morphology, the intestinal permeability was significantly enhanced by 1-10 μg/L 6-PPDQ as indicated by erioglaucine disodium staining. In addition, the expression of intestinal fatty acid transporter ACS-22 governing functional state of intestinal barrier was decreased by exposure to 1-10 μg/L 6-PPDQ. Meanwhile, intestinal reactive oxygen species (ROS) production was induced by 0.1-10 μg/L 6-PPDQ and lipofuscin accumulation reflected by intestinal autofluorescence was activated by 1-10 μg/L 6-PPDQ. Accompanied with activation of intestinal oxidative stress, expressions of some anti-oxidation related genes (ctl-2, sod-2, sod-3, and sod-4) were significantly increased by 0.1-10 μg/L 6-PPDQ. Moreover, intestinal RNAi of acs-22 strengthened the susceptibility of nematodes to intestinal toxicity of 6-PPDQ. Therefore, considering that the environmentally relevant concentrations of 6-PPDQ were ≤10 μg/L, our data suggested that long-term exposure to 6-PPDQ at environmentally relevant concentrations potentially results in intestinal toxicity by disrupting functional state of intestinal barrier in organisms.

Published
2023
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249. Heat Transfer Analysis of Methane Hydrate Sediment Dissociation in a Closed Reactor by a Thermal Method

Author

Mingjun Yang, Zhi Yang, Dayong Wang, Weiguo Liu, Yu Liu, Zihao Zhu, Kaihua Xue, Yongchen Song, Chuanxiao Cheng, and Jiafei Zhao

Subjects
methane hydrate, thermal method, dissociation, temperature difference, heat transfer, Technology
Abstract

The heat transfer analysis of hydrate-bearing sediment involved phase changes is one of the key requirements of gas hydrate exploitation techniques. In this paper, experiments were conducted to examine the heat transfer performance during hydrate formation and dissociation by a thermal method using a 5L volume reactor. This study simulated porous media by using glass beads of uniform size. Sixteen platinum resistance thermometers were placed in different position in the reactor to monitor the temperature differences of the hydrate in porous media. The influence of production temperature on the production time was also investigated. Experimental results show that there is a delay when hydrate decomposed in the radial direction and there are three stages in the dissociation period which is influenced by the rate of hydrate dissociation and the heat flow of the reactor. A significant temperature difference along the radial direction of the reactor was obtained when the hydrate dissociates and this phenomenon could be enhanced by raising the production temperature. In addition, hydrate dissociates homogeneously and the temperature difference is much smaller than the other conditions when the production temperature is around the 10 °C. With the increase of the production temperature, the maximum of ΔToi grows until the temperature reaches 40 °C. The period of ΔToi have a close relation with the total time of hydrate dissociation. Especially, the period of ΔToi with production temperature of 10 °C is twice as much as that at other temperatures. Under these experimental conditions, the heat is mainly transferred by conduction from the dissociated zone to the dissociating zone and the production temperature has little effect on the convection of the water in the porous media.

Published
2012
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