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202. Effects of rare kidney diseases on kidney failure: a longitudinal analysis of the UK National Registry of Rare Kidney Diseases (RaDaR) cohort

Author

Abat, Sharirose, Adalat, Shazia, Agbonmwandolor, Joy, Ahmad, Zubaidah, Alejmi, Abdulfattah, Almasarwah, Rashid, Annear, Nicholas, Asgari, Ellie, Ayers, Amanda, Baharani, Jyoti, Balasubramaniam, Gowrie, Kpodo, Felix, Bansal, Tarun, Barratt, Alison, Barratt, Jonathan, Bates, Megan, Bayne, Natalie, Bendle, Janet, Benyon, Sarah, Bergmann, Carsten, Bhandari, Sunil, Bingham, Coralie, Boddana, Preetham, Bond, Sally, Braddon, Fiona, Bramham, Kate, Branson, Angela, Brearey, Stephen, Brocklebank, Vicky, Budwal, Sharanjit, Byrne, Conor, Cairns, Hugh, Camilleri, Brian, Campbell, Gary, Capell, Alys, Carmody, Margaret, Carson, Marion, Cathcart, Tracy, Catley, Christine, Cesar, Karine, Chan, Melanie, Chea, Houda, Chess, James, Cheung, Chee Kay, Chick, Katy-Jane, Chitalia, Nihil, Christian, Martin, Chrysochou, Tina, Clark, Katherine, Clayton, Christopher, Clissold, Rhian, Cockerill, Helen, Coelho, Joshua, Colby, Elizabeth, Colclough, Viv, Conway, Eileen, Cook, H Terence, Cook, Wendy, Cooper, Theresa, Coward, Richard J, Crosbie, Sarah, Cserep, Gabor, Date, Anjali, Davidson, Katherine, Davies, Amanda, Dhaun, Neeraj, Dhaygude, Ajay, Diskin, Lynn, Dixit, Abhijit, Doctolero, Eunice, Dorey, Suzannah, Downard, Lewis, Drayson, Mark, Dreyer, Gavin, Dutt, Tina, Etuk, Kufreabasi, Evans, Dawn, Finch, Jenny, Flinter, Frances, Fotheringham, James, Francis, Lucy, Gale, Daniel P, Gallagher, Hugh, Game, David, Garcia, Eva, Gavrila, Madita, Gear, Susie, Geddes, Colin, Gilchrist, Mark, Gittus, Matt, Goggolidou, Paraskevi, Goldsmith, Christopher, Gooden, Patricia, Goodlife, Andrea, Goodwin, Priyanka, Grammatikopoulos, Tassos, Gray, Barry, Griffith, Megan, Gumus, Steph, Gupta, Sanjana, Hamilton, Patrick, Harper, Lorraine, Harris, Tess, Haskell, Louise, Hayward, Samantha, Hegde, Shivaram, Hendry, Bruce, Hewins, Sue, Hewitson, Nicola, Hillman, Kate, Hiremath, Mrityunjay, Howson, Alexandra, Htet, Zay, Huish, Sharon, Hull, Richard, Humphries, Alister, Hunt, David P J, Hunter, Karl, Hunter, Samantha, Ijeomah-Orji, Marilyn, Inston, Nick, Jayne, David, Jenfa, Gbemisola, Jenkins, Alison, Johnson, Sally, Jones, Caroline A, Jones, Colin, Jones, Amanda, Jones, Rachel, Kamesh, Lavanya, Kanigicherla, Durga, Karet Frankl, Fiona, Karim, Mahzuz, Kaur, Amrit, Kavanagh, David, Kearley, Kelly, Kerecuk, Larissa, Khwaja, Arif, King, Garry, King, Grant, Kislowska, Ewa, Klata, Edyta, Kokocinska, Maria, Lambie, Mark, Lawless, Laura, Ledson, Thomas, Lennon, Rachel, Levine, Adam P, Lai, Ling Wai Maggie, Lipkin, Graham, Lovitt, Graham, Lyons, Paul, Mabillard, Holly, Mackintosh, Katherine, Mahdi, Khalid, Maher, Eamonn, Marchbank, Kevin J, Mark, Patrick B, Masoud, Sherry, Masunda, Bridgett, Mavani, Zainab, Mayfair, Jake, McAdoo, Stephen, Mckinnell, Joanna, Melhem, Nabil, Meyrick, Simon, Moochhala, Shabbir, Morgan, Putnam, Morgan, Ann, Muhammad, Fawad, Murray, Shona, Novobritskaya, Kristina, Ong, Albert CM, Oni, Louise, Osmaston, Kate, Padmanabhan, Neal, Parkes, Sharon, Patrick, Jean, Pattison, James, Paul, Riny, Percival, Rachel, Perkins, Stephen J, Persu, Alexandre, Petchey, William G, Pickering, Matthew C, Pinney, Jennifer, Pitcher, David, Plumb, Lucy, Plummer, Zoe, Popoola, Joyce, Post, Frank, Power, Albert, Pratt, Guy, Pusey, Charles, Rabara, Ria, Rabuya, May, Raju, Tina, Javier, Chadd, Roberts, Ian S D, Roufosse, Candice, Rumjon, Adam, Salama, Alan, Saleem, Moin, Sandford, Richard, Sandu, Kanwaljit S, Sarween, Nadia, Sayer, John A, Sebire, Neil, Selvaskandan, Haresh, Sharma, Asheesh, Sharples, Edward J, Sheerin, Neil, Shetty, Harish, Shroff, Rukshana, Simms, Roslyn, Sinha, Manish, Sinha, Smeeta, Smith, Kerry, Smith, Lara, Srivastava, Shalabh, Steenkamp, Retha, Stott, Ian, Stroud, Katerina, Swift, Pauline, Szklarzewicz, Justyna, Tam, Fred, Tan, Kay, Taylor, Robert, Tischkowitz, Marc, Thomas, Kay, Tse, Yincent, Turnbull, Alison, Turner, A Neil, Tyerman, Kay, Usher, Miranda, Venkat-Raman, Gopalakrishnan, Walker, Alycon, Walsh, Stephen B, Waters, Aoife, Watt, Angela, Webster, Phil, Wechalekar, Ashutosh, Welsh, Gavin I, West, Nicol, Wheeler, David, Wiles, Kate, Willcocks, Lisa, Williams, Angharad, Williams, Emma, Williams, Karen, Wilson, Deborah H, Wilson, Patricia D, Winyard, Paul, Wong, Edwin, Wong, Katie, Wood, Grahame, Woodward, Emma, Woodward, Len, Woolf, Adrian, Wright, David, Downward, Lewis, Chrysochou, Constantina, Griffin, Sian, Hall, Matt, Maher, Eamonn R, Pinney, Jenny, Tam, Frederick W K, Turner, Andrew Neil, Wilson, Patricia, Taylor, Christopher Mark, Nitsch, Dorothea, and Bockenhauer, Detlef

Published
2024
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204. RIFM fragrance ingredient safety assessment, 2-sec-butylcyclohexanone, CAS Registry Number 14765-30-1

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Jr., Cancellieri, M.A., Chon, H., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., and Tokura, Y.

Published
2024
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205. RIFM fragrance ingredient safety assessment, 3-methyl-2,4-nonedione, CAS Registry Number 113486-29-6

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Jr., Cancellieri, M.A., Chon, H., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., and Tokura, Y.

Published
2024
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206. RIFM fragrance ingredient safety assessment, isoamyl isovalerate, CAS registry number 659-70-1

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Jr., Cancellieri, M.A., Chon, H., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., and Tokura, Y.

Published
2024
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207. RIFM fragrance ingredient safety assessment, methyl sorbate, CAS Registry Number 689-89-4

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Jr., Cancellieri, M.A., Chon, H., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., and Tokura, Y.

Published
2024
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208. RIFM fragrance ingredient safety assessment, 2-methylpropyl 2-methylbutyrate, CAS Registry Number 2445-67-2

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Jr., Cancellieri, M.A., Chon, H., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., and Tokura, Y.

Published
2024
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209. RIFM fragrance ingredient safety assessment, 2,6,10-trimethylundeca-5,9-dienol, CAS Registry Number 24048-14-4

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Jr., Cancellieri, M.A., Chon, H., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., and Tokura, Y.

Published
2024
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210. RIFM fragrance ingredient safety assessment, ethyl valerate, CAS Registry Number 539-82-2

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Jr., Cancellieri, M.A., Chon, H., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., and Tokura, Y.

Published
2024
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211. RIFM fragrance ingredient safety assessment, diethyl 1,4-cyclohexane dicarboxylate, CAS Registry Number 72903-27-6

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Jr., Cancellieri, M.A., Chon, H., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., and Tokura, Y.

Published
2024
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212. RIFM fragrance ingredient safety assessment, methyl valerate, CAS Registry Number 624-24-8

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Jr., Cancellieri, M.A., Chon, H., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., and Tokura, Y.

Published
2024
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213. RIFM fragrance ingredient safety assessment, isobutyl angelate, CAS Registry Number 7779-81-9

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Jr., Cancellieri, M.A., Chon, H., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., and Tokura, Y.

Published
2024
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214. RIFM fragrance ingredient safety assessment, 3-methyl-2-buten-1-ol, CAS registry number 556-82-1

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Jr., Cancellieri, M.A., Chon, H., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., and Tokura, Y.

Published
2024
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215. RIFM fragrance ingredient safety assessment, geranyl propionate, CAS Registry Number 105-90-8

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Jr., Cancellieri, M.A., Chon, H., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., and Tokura, Y.

Published
2024
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216. RIFM fragrance ingredient safety assessment, 11-oxahexadecanolide, CAS Registry Number 3391-83-1

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Jr., Cancellieri, M.A., Chon, H., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., and Tokura, Y.

Published
2024
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217. RIFM fragrance ingredient safety assessment, acetyl cedrene, CAS Registry Number 32388-55-9

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Jr., Cancellieri, M.A., Chon, H., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., and Tokura, Y.

Published
2024
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218. RIFM fragrance ingredient safety assessment, allyl trimethylhexanoate, CAS Registry Number 68132-80-9

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Jr., Cancellieri, M.A., Chon, H., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., and Tokura, Y.

Published
2024
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219. RIFM fragrance ingredient safety assessment, geranyl isovalerate, CAS Registry Number 109-20-6

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Jr., Cancellieri, M.A., Chon, H., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., and Tokura, Y.

Published
2024
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220. RIFM fragrance ingredient safety assessment, cyclohexanone,5-methyl-2-(1-methylethyl)-,oxime, CAS registry number 19096-86-7

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Jr., Cancellieri, M.A., Chon, H., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., and Tokura, Y.

Published
2024
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221. RIFM fragrance ingredient safety assessment, α-methylbenzyl isobutyrate, CAS Registry Number 7775-39-5

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Jr., Cancellieri, M.A., Chon, H., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., and Tokura, Y.

Published
2024
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222. RIFM fragrance ingredient safety assessment, 5,6,7-trimethylocta-2,5-dien-4-one, CAS Registry Number 358331-95-0

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Jr., Cancellieri, M.A., Chon, H., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., and Tokura, Y.

Published
2024
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223. RIFM fragrance ingredient safety assessment, hexyl methacrylate, CAS Registry Number 142-09-6

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Jr., Cancellieri, M.A., Chon, H., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., and Tokura, Y.

Published
2024
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224. RIFM fragrance ingredient safety assessment, ocimenyl acetate, CAS Registry Number 72214-23-4

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Jr., Cancellieri, M.A., Chon, H., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., and Tokura, Y.

Published
2024
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225. Update to RIFM fragrance ingredient safety assessment, 2-methylbutanol, CAS Registry Number 137-32-6

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Jr., Cancellieri, M.A., Chon, H., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., and Tokura, Y.

Published
2024
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226. RIFM fragrance ingredient safety assessment, phenylacetaldehyde 2,4-dihydroxy-2-methylpentane acetal, CAS Registry Number 67633-94-7

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Jr., Cancellieri, M.A., Chon, H., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., and Tokura, Y.

Published
2024
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227. RIFM fragrance ingredient safety assessment, 2-methyl-3-furanthiol, CAS Registry Number 28588-74-1

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Jr., Cancellieri, M.A., Chon, H., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., and Tokura, Y.

Published
2024
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228. RIFM fragrance ingredient safety assessment, patchouli alcohol, CAS Registry Number 5986-55-0

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Jr., Cancellieri, M.A., Chon, H., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., and Tokura, Y.

Published
2024
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229. RIFM fragrance ingredient safety assessment, phytol, CAS Registry Number 150-86-7

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Jr., Cancellieri, M.A., Chon, H., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., and Tokura, Y.

Published
2024
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230. RIFM fragrance ingredient safety assessment, geranyl formate, CAS Registry Number 105-86-2

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Jr., Cancellieri, M.A., Chon, H., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., and Tokura, Y.

Published
2024
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231. RIFM fragrance ingredient safety assessment, propyl butyrate, CAS Registry Number 105-66-8

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Jr., Cancellieri, M.A., Chon, H., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., and Tokura, Y.

Published
2024
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232. RIFM fragrance ingredient safety assessment, geranyl isobutyrate, CAS Registry Number 2345-26-8

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Jr., Cancellieri, M.A., Chon, H., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., and Tokura, Y.

Published
2024
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233. RIFM fragrance ingredient safety assessment, geranyl butyrate, CAS Registry Number 106-29-6

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Jr., Cancellieri, M.A., Chon, H., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., and Tokura, Y.

Published
2024
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234. RIFM fragrance ingredient safety assessment, 2-methylpropyl 3-methylbutyrate, CAS Registry Number 589-59-3

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Jr., Cancellieri, M.A., Chon, H., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., and Tokura, Y.

Published
2024
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235. RIFM fragrance ingredient safety assessment, ω-6-hexadecenlactone, CAS Registry Number 7779-50-2

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Jr., Cancellieri, M.A., Chon, H., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., and Tokura, Y.

Published
2024
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236. RIFM fragrance ingredient safety assessment, 4-hydroxy-3-pentenoic acid lactone, CAS Registry number 591-12-8

Author

Api, A.M., Belsito, D., Botelho, D., Bruze, M., Burton, G.A., Jr., Cancellieri, M.A., Chon, H., Dagli, M.L., Date, M., Dekant, W., Deodhar, C., Fryer, A.D., Jones, L., Joshi, K., Kumar, M., Lapczynski, A., Lavelle, M., Lee, I., Liebler, D.C., Moustakas, H., Na, M., Penning, T.M., Ritacco, G., Romine, J., Sadekar, N., Schultz, T.W., Selechnik, D., Siddiqi, F., Sipes, I.G., Sullivan, G., Thakkar, Y., and Tokura, Y.

Published
2024
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237. Niclosamide-loaded nanoparticles disrupt Candida biofilms and protect mice from mucosal candidiasis

Author

Sutar, Yogesh, Nabeela, Sunna, Singh, Shakti, Alqarihi, Abdullah, Solis, Norma, Ghebremariam, Teklegiorgis, Filler, Scott, Ibrahim, Ashraf S, Date, Abhijit, and Uppuluri, Priya

Subjects
Microbiology, Medical Microbiology, Biomedical and Clinical Sciences, Biological Sciences, Infectious Diseases, Antimicrobial Resistance, Prevention, 2.2 Factors relating to the physical environment, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Aetiology, Infection, Animals, Antifungal Agents, Biofilms, Candida, Candida albicans, Candidiasis, Fluconazole, Mice, Microbial Sensitivity Tests, Nanoparticles, Niclosamide, Agricultural and Veterinary Sciences, Medical and Health Sciences, Developmental Biology, Agricultural, veterinary and food sciences, Biological sciences, Biomedical and clinical sciences
Abstract

Candida albicans biofilms are a complex multilayer community of cells that are resistant to almost all classes of antifungal drugs. The bottommost layers of biofilms experience nutrient limitation where C. albicans cells are required to respire. We previously reported that a protein Ndu1 is essential for Candida mitochondrial respiration; loss of NDU1 causes inability of C. albicans to grow on alternative carbon sources and triggers early biofilm detachment. Here, we screened a repurposed library of FDA-approved small molecule inhibitors to identify those that prevent NDU1-associated functions. We identified an antihelminthic drug, Niclosamide (NCL), which not only prevented growth on acetate, C. albicans hyphenation and early biofilm growth, but also completely disengaged fully grown biofilms of drug-resistant C. albicans and Candida auris from their growth surface. To overcome the suboptimal solubility and permeability of NCL that is well known to affect its in vivo efficacy, we developed NCL-encapsulated Eudragit EPO (an FDA-approved polymer) nanoparticles (NCL-EPO-NPs) with high niclosamide loading, which also provided long-term stability. The developed NCL-EPO-NPs completely penetrated mature biofilms and attained anti-biofilm activity at low microgram concentrations. NCL-EPO-NPs induced ROS activity in C. albicans and drastically reduced oxygen consumption rate in the fungus, similar to that seen in an NDU1 mutant. NCL-EPO-NPs also significantly abrogated mucocutaneous candidiasis by fluconazole-resistant strains of C. albicans, in mice models of oropharyngeal and vulvovaginal candidiasis. To our knowledge, this is the first study that targets biofilm detachment as a target to get rid of drug-resistant Candida biofilms and uses NPs of an FDA-approved nontoxic drug to improve biofilm penetrability and microbial killing.

Published
2022

238. Neuromorphic Computing is Turing-Complete

Author

Date, Prasanna, Schuman, Catherine, Kay, Bill, and Potok, Thomas

Subjects
Computer Science - Neural and Evolutionary Computing, Computer Science - Computational Complexity, Computer Science - Computation and Language, Computer Science - Emerging Technologies, 68Q07, 03D10, F.1.1, D.1.m
Abstract

Neuromorphic computing is a non-von Neumann computing paradigm that performs computation by emulating the human brain. Neuromorphic systems are extremely energy-efficient and known to consume thousands of times less power than CPUs and GPUs. They have the potential to drive critical use cases such as autonomous vehicles, edge computing and internet of things in the future. For this reason, they are sought to be an indispensable part of the future computing landscape. Neuromorphic systems are mainly used for spike-based machine learning applications, although there are some non-machine learning applications in graph theory, differential equations, and spike-based simulations. These applications suggest that neuromorphic computing might be capable of general-purpose computing. However, general-purpose computability of neuromorphic computing has not been established yet. In this work, we prove that neuromorphic computing is Turing-complete and therefore capable of general-purpose computing. Specifically, we present a model of neuromorphic computing, with just two neuron parameters (threshold and leak), and two synaptic parameters (weight and delay). We devise neuromorphic circuits for computing all the {\mu}-recursive functions (i.e., constant, successor and projection functions) and all the {\mu}-recursive operators (i.e., composition, primitive recursion and minimization operators). Given that the {\mu}-recursive functions and operators are precisely the ones that can be computed using a Turing machine, this work establishes the Turing-completeness of neuromorphic computing.

Published
2021

239. Postoperative tegafur–uracil for stage I lung adenocarcinoma: first real-world data with an exploratory subgroup analysis

Author

Miyata, Ryo, Hamaji, Masatsugu, Nakakura, Akiyoshi, Morita, Satoshi, Shimazu, Yumeta, Ishikawa, Masashi, Kayawake, Hidenao, Menju, Toshi, Sakaguchi, Yasuto, Sonobe, Makoto, Takahashi, Mamoru, Aoyama, Akihiro, Sumitomo, Ryota, Huang, Cheng-Long, Kono, Tomoya, Miyahara, Ryo, Matsumoto, Akira, Katakura, Hiromichi, Fukada, Takahisa, Sakai, Hiroaki, Kobayashi, Masashi, Okumura, Norihito, Date, Naoki, Fujinaga, Takuji, Miyamoto, Ei, Nakagawa, Tatsuo, and Date, Hiroshi

Published
2023
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243. MS785-MS27 Reactive Misfolded/Non-Native Zn-Deficient SOD1 Species Exhibit Cytotoxicity and Adopt Heterozygous Conformations in Motor Neurons

Author

Eiichi Tokuda, Yume Sakashita, Naoya Tokoro, Ayano Date, Yasuhiro Kosuge, and Tomohiro Miyasaka

Subjects
amyotrophic lateral sclerosis, MS785-MS27 antibody cocktail, Zn-deficient SOD1, recombinant proteins, Biology (General), QH301-705.5, Chemistry, QD1-999
Abstract

Misfolding of superoxide dismutase-1 (SOD1) is a pathological hallmark of amyotrophic lateral sclerosis (ALS) with SOD1 mutations. The development of antibodies specific for misfolded SOD1 deepens our understanding of how the protein participates in ALS pathogenesis. Since the term “misfolding” refers to various disordered conformers other than the natively folded one, which misfolded species are recognized by specific antibodies should be determined. Here, we molecularly characterized the recognition by MS785-MS27, an antibody cocktail experimentally confirmed to recognize over 100 ALS-linked SOD1 mutants. Indirect ELISA revealed that the antibody cocktail recognized Zn-deficient wild-type and mutated SOD1 species. It also recognized conformation-disordered wild-type and mutated SOD1 species, such as unfolded and oligomeric forms, but had less affinity for the aggregated form. Antibody-reactive SOD1 exhibited cytotoxicity to a motor neuron cell model, which was blocked by Zn treatment with Zn-deficient SOD1. Immunohistochemistry revealed antibody-reactive SOD1 mainly in spinal motor neurons of SOD1G93A mice throughout the disease course, and the distribution after symptomatic stages differed from that of other misfolded SOD1 species. This suggests that misfolded/non-native SOD1 species exist as heterogeneous populations. In conclusion, MS785-MS27 recognizes various conformation-disordered SOD1 species lacking the Zn ion.

Published
2024
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244. Statistical modeling of pneumothorax deformation by mapping CT and cone-beam CT images

Author

Nakao, Megumi, Maekawa, Hinako, Mineura, Katsutaka, Chen-Yoshikawa, Toyofumi F., Date, Hiroshi, and Matsuda, Tetsuya

Subjects
Computer Science - Computational Geometry, Mathematics - Numerical Analysis
Abstract

In this study, we introduce statistical modeling methods for pneumothorax deformation using paired cone-beam computed tomography (CT) images. We designed a deformable mesh registration framework for shape changes involving non-linear deformation and rotation of the lungs. The registered meshes with local correspondences are available for both surgical guidance in thoracoscopic surgery and building statistical deformation models with inter-patient variations. In addition, a kernel-based deformation learning framework is proposed to reconstruct intraoperative deflated states of the lung from the preoperative CT models. This paper reports the findings of pneumothorax deformation and evaluation results of the kernel-based deformation framework.

Published
2020

249. An ASR Corpus in Chhattisgarhi, a Low Resource Indian Language.

Author

Abhayjeet Singh, Arjun Singh Mehta, Ashish Khuraishi K. S, Deekshitha G, Gauri Date, Jai Nanavati, Jesuraja Bandekar, Karnalius Basumatary, Karthika P, Sandhya Badiger, Sathvik Udupa, Saurabh Kumar, Prasanta Kumar Ghosh, Prashanthi V, Priyanka Pai, Raoul Nanavati, Sai Praneeth Reddy Mora, and Srinivasa Raghavan K. M.

Published
2023
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