1,363 results on '"Dao, M."'
Search Results
202. A data integration multi-omics approach to study calorie restriction-induced changes in insulin sensitivity
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Dao, M. C., Sokolovska, N., Brazeilles, R., Affeldt, S., Pelloux, V., Prifti, E., Chilloux, J., Verger, E., Kayser, B. D., Aron-Wisnewsky, J., Ichou, F., Pujos-Guillot, E., Hoyles, L., Juste, C., Dore, J., Dumas, M. E., Rizkalla, S. W., Holmes, B. A., Zucker, Jean-Daniel, Clement, K., and Micro-Obes Consortium
- Subjects
microbiota ,insulin sensitivity ,lifestyle factors ,data integration ,omics - Abstract
Background: The mechanisms responsible for calorie restriction (CR)-induced improvement in insulin sensitivity (IS) have not been fully elucidated. Greater insight can be achieved through deep biological phenotyping of subjects undergoing CR, and integration of big data. Materials and Methods: An integrative approach was applied to investigate associations between change in IS and factors from host, microbiota, and lifestyle after a 6-week CR period in 27 overweight or obese adults (ClinicalTrials.gov: NCT01314690). Partial least squares regression was used to determine associations of change (week 6 - baseline) between IS markers and lifestyle factors (diet and physical activity), subcutaneous adipose tissue (sAT) gene expression, metabolomics of serum, urine and feces, and gut microbiota composition. ScaleNet, a network learning approach based on spectral consensus strategy (SCS, developed by us) was used for reconstruction of biological networks. Results: A spectrum of variables from lifestyle factors (10 nutrients), gut microbiota (10 metagenomics species), and host multi-omics (metabolic features: 84 from serum, 73 from urine, and 131 from feces; and 257 sAT gene probes) most associated with IS were identified. Biological network reconstruction using SCS, highlighted links between changes in IS, serum branched chain amino acids, sAT genes involved in endoplasmic reticulum stress and ubiquitination, and gut metagenomic species (MGS). Linear regression analysis to model how changes of select variables over the CR period contribute to changes in IS, showed greatest contributions from gut MGS and fiber intake. Conclusion: This work has enhanced previous knowledge on links between host glucose homeostasis, lifestyle factors and the gut microbiota, and has identified potential biomarkers that may be used in future studies to predict and improve individual response to weight-loss interventions. Furthermore, this is the first study showing integration of the wide range of data presented herein, identifying 115 variables of interest with respect to IS from the initial input, consisting of 9,986 variables.
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- 2019
203. Elevated serum ceramides are linked with obesity-associated gut dysbiosis and impaired glucose metabolism
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Kayser, B. D., Prifti, E., Lhomme, M., Belda, E., Dao, M. C., Aron-Wisnewsky, J., Kontush, A., Zucker, Jean-Daniel, Rizkalla, S. W., Dugail, I., Clement, K., Kennedy, S. P., Pons, N., Le Chatelier, E., Almeida, M., Quinquis, B., Galleron, N., Batto, J. M., Renault, P., Ehrlich, S. D., Blottiere, H., Leclerc, M., de Wouters, T., Lepage, P., Dore, J., and MICRO-Obes Consortium
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Sphingolipids ,Glucose metabolism ,Endotoxin ,Microbiome ,Ceramides - Abstract
Introduction Low gut microbiome richness is associated with dyslipidemia and insulin resistance, and ceramides and other sphingolipids are implicated in the development of diabetes. Objectives Determine whether circulating sphingolipids, particularly ceramides, are associated with alterations in the gut microbiome among obese patients with increased diabetes risk. Methods This was a cross-sectional and longitudinal retrospective analysis of a dietary/weight loss intervention. Fasted serum was collected from 49 participants (41 women) and analyzed by HPLC-MS/MS to quantify 45 sphingolipids. Shotgun metagenomic sequencing of stool was performed to profile the gut microbiome. Results Confirming the link to deteriorated glucose homeostasis, serum ceramides were positively correlated with fasting glucose, but inversely correlated with fasting and OGTT-derived measures of insulin sensitivity and beta-cell function. Significant associations with gut dysbiosis were demonstrated, with SM and ceramides being inversely correlated with gene richness. Ceramides with fatty acid chain lengths of 20-24 carbons were the most associated with low richness. Diet-induced weight loss, which improved gene richness, decreased most sphingolipids. Thirty-one MGS, mostly corresponding to unidentified bacteria species, were inversely correlated with ceramides, including a number of Bifidobacterium and Methanobrevibacter smithii. Higher ceramide levels were also associated with increased metagenomic modules for lipopolysaccharide synthesis and flagellan synthesis, two pathogen-associated molecular patterns, and decreased enrichment of genes involved in methanogenesis and bile acid metabolism. Conclusion This study identifies an association between gut microbiota richness, ceramides, and diabetes risk in overweight/obese humans, and suggests that the gut microbiota may contribute to dysregulation of lipid metabolism in metabolic disorders.
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- 2019
204. Large expert-curated database for benchmarking document similarity detection in biomedical literature search
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Brown, P. Zhou, Y. Tan, A.-C. El-Esawi, M.A. Liehr, T. Blanck, O. Gladue, D.P. Almeida, G.M.F. Cernava, T. Sorzano, C.O. Yeung, A.W.K. Engel, M.S. Chandrasekaran, A.R. Muth, T. Staege, M.S. Daulatabad, S.V. Widera, D. Zhang, J. Meule, A. Honjo, K. Pourret, O. Yin, C.-C. Zhang, Z. Cascella, M. Flegel, W.A. Goodyear, C.S. van Raaij, M.J. Bukowy-Bieryllo, Z. Campana, L.G. Kurniawan, N.A. Lalaouna, D. Hüttner, F.J. Ammerman, B.A. Ehret, F. Cobine, P.A. Tan, E.-C. Han, H. Xia, W. McCrum, C. Dings, R.P.M. Marinello, F. Nilsson, H. Nixon, B. Voskarides, K. Yang, L. Costa, V.D. Bengtsson-Palme, J. Bradshaw, W. Grimm, D.G. Kumar, N. Martis, E. Prieto, D. Sabnis, S.C. Amer, S.E.D.R. Liew, A.W.C. Perco, P. Rahimi, F. Riva, G. Zhang, C. Devkota, H.P. Ogami, K. Basharat, Z. Fierz, W. Siebers, R. Tan, K.H. Boehme, K.A. Brenneisen, P. Brown, J.A.L. Dalrymple, B.P. Harvey, D.J. Ng, G. Werten, S. Bleackley, M. Dai, Z. Dhariwal, R. Gelfer, Y. Hartmann, M.D. Miotla, P. Tamaian, R. Govender, P. Gurney-Champion, O.J. Kauppila, J.H. Zhang, X. Echeverría, N. Subhash, S. Sallmon, H. Tofani, M. Bae, T. Bosch, O. Cuív, P.O. Danchin, A. Diouf, B. Eerola, T. Evangelou, E. Filipp, F. Klump, H. Kurgan, L. Smith, S.S. Terrier, O. Tuttle, N. Ascher, D.B. Janga, S.C. Schulte, L.N. Becker, D. Browngardt, C. Bush, S.J. Gaullier, G. Ide, K. Meseko, C. Werner, G.D.A. Zaucha, J. Al-Farha, A.A. Greenwald, N.F. Popoola, S.I. Rahman, S. Xu, J. Yang, S.Y. Hiroi, N. Alper, O.M. Baker, C.I. Bitzer, M. Chacko, G. Debrabant, B. Dixon, R. Forano, E. Gilliham, M. Kelly, S. Klempnauer, K.-H. Lidbury, B.A. Lin, M.Z. Lynch, I. Ma, W. Maibach, E.W. Mather, D.E. Nandakumar, K.S. Ohgami, R.S. Parchi, P. Tressoldi, P. Xue, Y. Armitage, C. Barraud, P. Chatzitheochari, S. Coelho, L.P. Diao, J. Doxey, A.C. Gobet, A. Hu, P. Kaiser, S. Mitchell, K.M. Salama, M.F. Shabalin, I.G. Song, H. Stevanovic, D. Yadollahpour, A. Zeng, E. Zinke, K. Alimba, C.G. Beyene, T.J. Cao, Z. Chan, S.S. Gatchell, M. Kleppe, A. Piotrowski, M. Torga, G. Woldesemayat, A.A. Cosacak, M.I. Haston, S. Ross, S.A. Williams, R. Wong, A. Abramowitz, M.K. Effiong, A. Lee, S. Abid, M.B. Agarabi, C. Alaux, C. Albrecht, D.R. Atkins, G.J. Beck, C.R. Bonvin, A.M.J.J. Bourke, E. Brand, T. Braun, R.J. Bull, J.A. Cardoso, P. Carter, D. Delahay, R.M. Ducommun, B. Duijf, P.H.G. Epp, T. Eskelinen, E.-L. Fallah, M. Farber, D.B. Fernandez-Triana, J. Feyerabend, F. Florio, T. Friebe, M. Furuta, S. Gabrielsen, M. Gruber, J. Grybos, M. Han, Q. Heinrich, M. Helanterä, H. Huber, M. Jeltsch, A. Jiang, F. Josse, C. Jurman, G. Kamiya, H. de Keersmaecker, K. Kristiansson, E. de Leeuw, F.-E. Li, J. Liang, S. Lopez-Escamez, J.A. Lopez-Ruiz, F.J. Marchbank, K.J. Marschalek, R. Martín, C.S. Miele, A.E. Montagutelli, X. Morcillo, E. Nicoletti, R. Niehof, M. O'Toole, R. Ohtomo, T. Oster, H. Palma, J.-A. Paterson, R. Peifer, M. Portilla, M. Portillo, M.C. Pritchard, A.L. Pusch, S. Raghava, G.P.S. Roberts, N.J. Ross, K. Schuele, B. Sergeant, K. Shen, J. Stella, A. Sukocheva, O. Uversky, V.N. Vanneste, S. Villet, M.H. Viveiros, M. Vorholt, J.A. Weinstock, C. Yamato, M. Zabetakis, I. Zhao, X. Ziegler, A. Aizat, W.M. Atlas, L. Bridges, K.M. Chakraborty, S. Deschodt, M. Domingues, H.S. Esfahlani, S.S. Falk, S. Guisado, J.L. Kane, N.C. Kueberuwa, G. Lau, C.L. Liang, D. Liu, E. Luu, A.M. Ma, C. Ma, L. Moyer, R. Norris, A.D. Panthee, S. Parsons, J.R. Peng, Y. Pinto, I.M. Reschke, C.R. Sillanpää, E. Stewart, C.J. Uhle, F. Yang, H. Zhou, K. Zhu, S. Ashry, M. Bergsland, N. Berthold, M. Chen, C.-E. Colella, V. Cuypers, M. Eskew, E.A. Fan, X. Gajda, M. Gonzálezlez-Prendes, R. Goodin, A. Graham, E.B. Groen, E.J.N. Gutiérrez-Sacristán, A. Habes, M. Heffler, E. Higginbottom, D.B. Janzen, T. Jayaraman, J. Jibb, L.A. Jongen, S. Kinyanjui, T. Koleva-Kolarova, R.G. Li, Z. Liu, Y.-P. Lund, B.A. Lussier, A.A. Ma, L. Mier, P. Moore, M.D. Nagler, K. Orme, M.W. Pearson, J.A. Prajapati, A.S. Saito, Y. Tröder, S.E. Uchendu, F. Verloh, N. Voutchkova, D.D. Abu-Zaid, A. Bakkach, J. Baumert, P. Dono, M. Hanson, J. Herbelet, S. Hobbs, E. Kulkarni, A. Kumar, N. Liu, S. Loft, N.D. Reddan, T. Senghore, T. Vindin, H. Xu, H. Bannon, R. Chen, B. Cheung, J.T.K. Cooper, J. Esnakula, A.K. Feghali, K.A. Ghelardi, E. Gnasso, A. Horbar, J. Lai, H.M. Li, J. Ma, L. Ma, R. Pan, Z. Peres, M.A. Pranata, R. Seow, E. Sydes, M. Testoni, I. Westermair, A.L. Yang, Y. Afnan, M. Albiol, J. Albuquerque, L.G. Amir, S. Amiya, E. Amorim, R.M. An, Q. Andersen, S.U. Aplin, J.D. Argyropoulos, C. Asmann, Y.W. Assaeed, A.M. Atanasov, A.G. Atchison, D.A. Avery, S.V. Avillach, P. Baade, P.D. Backman, L. Badie, C. Baldi, A. Ball, E. Bardot, O. Barnett, A.G. Basner, M. Batra, J. Bazanova, O.M. Beale, A. Beddoe, T. Bell, M.L. Berezikov, E. Berners-Price, S. Bernhardt, P. Berry, E. Bessa, T.B. Billington, C. Birch, J. Blakely, R.D. Blaskovich, M.A.T. Blum, R. Boelaert, M. Bogdanos, D. Bosch, C. Bourgoin, T. Bouvard, D. Boykin, L.M. Bradley, G. Braun, D. Brownlie, J. Brühl, A. Burt, A. Butler, L.M. Byrareddy, S.N. Byrne, H.J. Cabantous, S. Calatayud, S. Candal, E. Carlson, K. Casillas, S. Castelvetro, V. Caswell, P.T. Cavalli, G. Cerovsky, V. Chagoyen, M. Chen, C.-S. Chen, D.F. Chen, H. Chen, H. Chen, J.-T. Chen, Y. Cheng, C. Cheng, J. Chinapaw, M. Chinopoulos, C. Cho, W.C.S. Chong, L. Chowdhury, D. Chwalibog, A. Ciresi, A. Cockcroft, S. Conesa, A. Cook, P.A. Cooper, D.N. Coqueret, O. Corea, E.M. Costa, A. Costa, E. Coupland, C. Crawford, S.Y. Cruz, A.D. Cui, H. Cui, Q. Culver, D.C. D'Angiulli, A. Dahms, T.E.S. Daigle, F. Dalgleish, R. Danielsen, H.E. Darras, S. Davidson, S.M. Day, D.A. Degirmenci, V. Demaison, L. Devriendt, K. Ding, J. Dogan, Y. Dong, X.C. Donner, C.F. Dressick, W. Drevon, C.A. Duan, H. Ducho, C. Dumaz, N. Dwarakanath, B.S. Ebell, M.H. Eisenhardt, S. Elkum, N. Engel, N. Erickson, T.B. Fairhead, M. Faville, M.J. Fejzo, M.S. Festa, F. Feteira, A. Flood-Page, P. Forsayeth, J. Fox, S.A. Franks, S.J. Frentiu, F.D. Frilander, M.J. Fu, X. Fujita, S. Galea, I. Galluzzi, L. Gani, F. Ganpule, A.P. García-Alix, A. Gedye, K. Giordano, M. Giunta, C. Gleeson, P.A. Goarant, C. Gong, H. Gora, D. Gough, M.J. Goyal, R. Graham, K.E. Grande-Pérez, A. Graves, P.M. Greidanus, H. Grice, D. Grunau, C. Gumulya, Y. Guo, Y. Gurevich, V.V. Gusev, O. Hacker, E. Hage, S.R. Hagen, G. Hahn, S. Haller, D.M. Hammerschmidt, S. Han, J. Han, R. Handfield, M. Hapuarachchi, H.C. Harder, T. Hardingham, J.E. Heck, M. Heers, M. Hew, K.F. Higuchi, Y. Hilaire, C.St. Hilton, R. Hodzic, E. Hone, A. Hongoh, Y. Hu, G. Huber, H.P. Hueso, L.E. Huirne, J. Hurt, L. Idborg, H. Ikeo, K. Ingley, E. Jakeman, P.M. Jensen, A. Jia, H. Jia, H. Jia, S. Jiang, J. Jiang, X. Jin, Y. Jo, D. Johnson, A.M. Johnston, M. Jonscher, K.R. Jorens, P.G. Jorgensen, J.O.L. Joubert, J.W. Jung, S.-H. Junior, A.M. Kahan, T. Kamboj, S.K. Kang, Y.-K. Karamanos, Y. Karp, N.A. Kelly, R. Kenna, R. Kennedy, J. Kersten, B. Khalaf, R.A. Khalid, J.M. Khatlani, T. Khider, T. Kijanka, G.S. King, S.R.B. Kluz, T. Knox, P. Kobayashi, T. Koch, K.-W. Kohonen-Corish, M.R.J. Kong, X. Konkle-Parker, D. Korpela, K.M. Kostrikis, L.G. Kraiczy, P. Kratz, H. Krause, G. Krebsbach, P.H. Kristensen, S.R. Kumari, P. Kunimatsu, A. Kurdak, H. Kwon, Y.D. Lachat, C. Lagisz, M. Laky, B. Lammerding, J. Lange, M. Larrosa, M. Laslett, A.L. Laverman, G.D. Leclair, E.E. Lee, K.-W. Lee, M.-Y. Lee, M.-S. Li, G. Li, J. Lieb, K. Lim, Y.Y. Lindsey, M.L. Line, P.-D. Liu, D. Liu, F. Liu, H. Liu, H. Lloyd, V.K. Lo, T.-W. Locci, E. Loidl, J. Lorenzen, J. Lorkowski, S. Lovell, N.H. Lu, H. Lu, W. Lu, Z. Luengo, G.S. Lundh, L.-G. Lysy, P.A. Mabb, A. Mack, H.G. Mackey, D.A. Mahdavi, S.R. Maher, P. Maher, T. Maity, S.N. Malgrange, B. Mamoulakis, C. Mangoni, A.A. Manke, T. Manstead, A.S.R. Mantalaris, A. Marsal, J. Marschall, H.-U. Martin, F.L. Martinez-Raga, J. Martinez-Salas, E. Mathieu, D. Matsui, Y. Maza, E. McCutcheon, J.E. McKay, G.J. McMillan, B. McMillan, N. Meads, C. Medina, L. Merrick, B.A. Metzger, D.W. Meunier, F.A. Michaelis, M. Micheau, O. Mihara, H. Mintz, E.M. Mizukami, T. Moalic, Y. Mohapatra, D.P. Monteiro, A. Montes, M. Moran, J.V. Morozov, S.Y. Mort, M. Murai, N. Murphy, D.J. Murphy, S.K. Murray, S.A. Naganawa, S. Nammi, S. Nasios, G. Natoli, R.M. Nguyen, F. Nicol, C. van Nieuwerburgh, F. Nilsen, E.B. Nobile, C.J. O'Mahony, M. Ohlsson, S. Olatunbosun, O. Olofsson, P. Ortiz, A. Ostrikov, K. Otto, S. Outeiro, T.F. Ouyang, S. Paganoni, S. Page, A. Palm, C. Paradies, Y. Parsons, M.H. Parsons, N. Pascal, P. Paul, E. Peckham, M. Pedemonte, N. Pellizzon, M.A. Petrelli, M. Pichugin, A. Pinto, C.J.C. Plevris, J.N. Pollesello, P. Polz, M. Ponti, G. Porcelli, P. Prince, M. Quinn, G.P. Quinn, T.J. Ramula, S. Rappsilber, J. Rehfeldt, F. Reiling, J.H. Remacle, C. Rezaei, M. Riddick, E.W. Ritter, U. Roach, N.W. Roberts, D.D. Robles, G. Rodrigues, T. Rodriguez, C. Roislien, J. Roobol, M.J. Rowe, A. Ruepp, A. van Ruitenbeek, J. Rust, P. Saad, S. Sack, G.H. Santos, M. Saudemont, A. Sava, G. Schrading, S. Schramm, A. Schreiber, M. Schuler, S. Schymkowitz, J. Sczyrba, A. Seib, K.L. Shi, H.-P. Shimada, T. Shin, J.-S. Shortt, C. Silveyra, P. Skinner, D. Small, I. Smeets, P.A.M. So, P.-W. Solano, F. Sonenshine, D.E. Song, J. Southall, T. Speakman, J.R. Srinivasan, M.V. Stabile, L.P. Stasiak, A. Steadman, K.J. Stein, N. Stephens, A.W. Stewart, D.I. Stine, K. Storlazzi, C. Stoynova, N.V. Strzalka, W. Suarez, O.M. Sultana, T. Sumant, A.V. Summers, M.J. Sun, G. Tacon, P. Tanaka, K. Tang, H. Tanino, Y. Targett-Adams, P. Tayebi, M. Tayyem, R. Tebbe, C.C. Telfer, E.E. Tempel, W. Teodorczyk-Injeyan, J.A. Thijs, G. Thorne, S. Thrift, A.G. Tiffon, C. Tinnefeld, P. Tjahjono, D.H. Tolle, F. Toth, E. Del Tredici, A.L. Tsapas, A. Tsirigotis, K. Turak, A. Tzotzos, G. Udo, E.E. Utsumi, T. Vaidyanathan, S. Vaillant, M. Valsesia, A. Vandenbroucke, R.E. Veiga, F.H. Vendrell, M. Vesk, P.A. Vickers, P. Victor, V.M. Villemur, R. Vohl, M.-C. Voolstra, C.R. Vuillemin, A. Wakelin, S. Waldron, L. Walsh, L.J. Wang, A.Y. Wang, F. Wang, Y. Watanabe, Y. Weigert, A. Wen, J.-C. Wham, C. White, E.P. Wiener, J. Wilharm, G. Wilkinson, S. Willmann, R. Wilson, C. Wirth, B. Wojan, T.R. Wolff, M. Wong, B.M. Wu, T.-W. Wuerbel, H. Xiao, X. Xu, D. Xu, J.W. Xu, J. Xue, B. Yalcin, S. Yan, H. Yang, E.-C. Yang, S. Yang, W. Ye, Y. Ye, Z.-Q. Yli-Kauhaluoma, J. Yoneyama, H. Yu, Y. Yuan, G.-C. Yuh, C.-H. Zaccolo, M. Zeng, C. Zevnik, B. Zhang, C. Zhang, L. Zhang, Y. Zhang, Y. Zhang, Z. Zhang, Z.-Y. Zhao, Y. Zhou, M. Zuberbier, T. Aanei, C.M. Ahmad, R. Al-Lawama, M. Alanio, A. Allardyce, J. Alonso-Caneiro, D. Atack, J.M. Baier, D. Bansal, A. Benezeth, Y. Berbesque, C. Berrevoet, F. Biedermann, P.H.W. Bijleveld, E. Bittner, F. Blombach, F. van den Bos, W. Boudreau, S.A. Bramoweth, A.D. Braubach, O. Cai, Y. Campbell, M. Cao, Z. Catry, T. Chen, X. Cheng, S. Chung, H.-J. Chávez-Fumagalli, M.A. Conway, A. Costa, B.M. Cyr, N. Dean, L.T. Denzel, M.S. Dlamini, S.V. Dudley, K.J. Dufies, M. Ecke, T. Eckweiler, D. Eixarch, E. El-Adawy, H. Emmrich, J.V. Eustace, A.J. Falter-Wagner, C.M. Farhoudi, R. Fuss, J. Gao, J. Gill, M.R. Gloyn, L. Goggs, R. Govinden, U. Greene, G. Greiff, V. Grundle, D.S. Grüneberg, P. Gumede, N. Haore, G. Harrison, P. Hoenner, X. Hojsgaard, D. Hori, H. Ikonomopoulou, M.P. Jeurissen, P. Johnson, D.M. Kabra, D. Kamagata, K. Karmakar, C. Kasian, O. Kaye, L.K. Khan, M.M. Kim, Y.-M. Kish, J.K. Kobold, S. Kohanbash, G. Kohls, G. Kugler, J.-M. Kumar, G. Lacy-Colson, J. Latif, A. Lauschke, V.M. Li, B. Lim, C.J. Liu, F. Liu, X. Lu, J.-J. Lu, Q. Mahavadi, P. Marzocchi, U. McGarrigle, C.A. van Meerten, T. Min, R. Moal, I. Molari, M. Molleman, L. Mondal, S.R. van de Mortel, T. Moss, W.N. Moultos, O.A. Mukherjee, M. Nakayama, K. Narayan, E. Navaratnarajah Neumann, P.-A. Nie, J. Nie, Y. Niemeyer, F. Nolan, F. Nwaiwu, O. Oldenmenger, W.H. Olumayede, E. Ou, J. Pallebage-Gamarallage, M. Pearce, S.P. Pelkonen, T. Pelleri, M.C. Pereira, J.L. Pheko, M. Pinto, K.A. Piovesan, A. Pluess, M. Podolsky, I.M. Prescott, J. Qi, D. Qi, X. Raikou, V.D. Ranft, A. Rhodes, J. Rotge, J.-Y. Rowe, A.D. Saggar, M. Schuon, R.A. Shahid, S. Shalchyan, V. Shirvalkar, P. Shiryayev, O. Singh, J. Smout, M.J. Soares, A. Song, C. Srivastava, K. Srivastava, R.K. Sun, J. Szabo, A. Szymanski, W. Tai, C.N.P. Takeuchi, H. Tanadini-Lang, S. Tang, F. Tao, W. Theron, G. Tian, C.F. Tian, Y.-S. Tuttle, L.M. Valenti, A. Verlot, P. Walker, M. Wang, J. Welter, D. Winslade, M. Wu, D. Wu, Y.-R. Xiao, H. Xu, B. Xu, J. Xu, Z. Yang, D. Yang, M. Yankilevich, P. You, Y. Yu, C. Zhan, J. Zhang, G. Zhang, K. Zhang, T. Zhang, Y. Zhao, G. Zhao, J. Zhou, X. Zhu, Z. Ajani, P.A. Anazodo, U.C. Bagloee, S.A. Bail, K. Bar, I. Bathelt, J. Benkeser, D. Bernier, M.L. Blanchard, A.M. Boakye, D.W. Bonatsos, V. Boon, M.H. Bouboulis, G. Bromfield, E. Brown, J. Bul, K.C.M. Burton, K.J. Butkowski, E.G. Carroll, G. Chao, F. Charrier, E.E. Chen, X. Chen, Y.-C. Chenguang Choi, J.R. Christoffersen, T. Comel, J.C. Cosse, C. Cui, Y. van Dessel, P. Dhaval Diodato, D. Duffey, M. Dutt, A. Egea, L.G. El-Said, M. Faye, M. Fernandez-Fernandez, B. Foley, K.G. Founou, L.L. Fu, F. Gadelkareem, R.A. Galimov, E. Garip, G. Gemmill, A. Gouil, Q. Grey, J. Gridneva, Z. Grothe, M.J. Grébert, T. Guerrero, F. Guignard, L. Haenssgen, M.J. Hasler, D. Holgate, J.Y. Huang, A. Hulse-Kemp, A.M. Jean-Quartier, C. Jeon, S.-M. Jia, Y. Jutzeler, C. Kalatzis, P. Karim, M. Karsay, K. Keitel, A. Kempe, A. Keown, J.R. Khoo, C.M. Khwaja, N. Kievit, R.A. Kosanic, S. Koutoukidis, D.A. Kramer, P. Kumar, D. Kiraǧ, N. Lanza, G. Le, T.D. Leem, J.W. Leightley, D. Leite, A. Lercher, L. Li, Y. Lim, R. Lima, L.R.A. Lin, L. Ling, T. Liu, Y. Liu, Z. Lu, Y. Lum, F.M. Luo, H. Machhi, J. Macleod, A. Macwan, I. Madala, H.R. Madani, N. de Maio, N. Makowiecki, K. Mallinson, D.J. Margelyte, R. Maria, C. Markonis, Y. Marsili, L. Mavoa, S. McWilliams, L. Megersa, M. Souto-Maior, C. Menichetti, J. Mercieca-Bebber, R. Miller, J.J. Minde, D.-P.M. Minges, A. Mishra, E. Mishra, V.R. Moores, C. Morrice, N. Moskalensky, A.E. Navarin, N. Negera, E. Nolet, P. Nordberg, A. Nordén, R. Nowicki, J.P. Olova, N. Olszewski, P. Onzima, R. Pan, C.-L. Park, C. Park, D.I. Park, S. Patil, C.D. Pedro, S.A. Perry, S.R. Peter, J. Peterson, B.M. Pezzuolo, A. Pozdnyakov, I. Qian, S. Qin, L. Rafe, A. Raote, I. Raza, A. Rebl, H. Refai, O. Regan, T. Richa, T. Richardson, M.F. Robinson, K.R. Rossoni, L. Rouet, R. Safaei, S. Schneeberger, P.H.H. Schwotzer, D. Sebastian, A. Selinski, J. Seltmann, S. Sha, F. Shalev, N. Shang, J.-L. Singer, J. Singh, M. Smith, T. Solomon-Moore, E. Song, L. Soraggi, S. Stanley, R. Steckhan, N. Strobl, F. Subissi, L. Supriyanto, I. Surve, C.R. Suzuki, T. Syme, C. Sörelius, K. Tang, Y. Tantawy, M. Tennakoon, S. Teseo, S. Toelzer, C. Tomov, N. Tovar, M. Tran, L. Tripathi, S. Tuladhar, A.M. Ukubuiwe, A.C. Ung, C.O.L. Valgepea, K. Vatanparast, H. Vidal, A. Wang, F. Wang, Q. Watari, R. Webster, R. Webster, R. Wei, J. Wibowo, D. Wingenbach, T.S.H. Xavier, R.M. Xiao, S. Xiong, P. Xu, S. Xu, S. Yao, R. Yao, W. Yin, Q. Yu, Y. Zaitsu, M. Zeineb, Z. Zhan, X.-Y. Zhang, J. Zhang, R. Zhang, W. Zhang, X. Zheng, S. Zhou, B. Zhou, X. Ahmad, H. Akinwumi, S.A. Albery, G.F. Alhowimel, A. Ali, J. Alshehri, M. Alsuhaibani, M. Anikin, A. Azubuike, S.O. Bach-Mortensen, A. Baltiansky, L. Bartas, M. Belachew, K.Y. Bhardwaj, V. Binder, K. Bland, N.S. Boah, M. Bullen, B. Calabrò, G.E. Callahan, T.J. Cao, B. Chalmers, K. Chang, W. Che, Z. Chen, A.T.Y. Chen, H. Chen, H. Chen, Y. Chen, Z. Choi, Y. Chowdhury, M.A.K. Christensen, M.R. Cooke, R.S.C. Cottini, M. Covington, N.V. Cunningham, C. Delarocque, J. Devos, L. Dhar, A.R. Ding, K.-F. Dong, K. Dong, Z. Dreyer, N. Ekstrand, C. Fardet, T. Feleke, B.E. Feurer, T. Freitas, A. Gao, T. Gebremedhin Giganti, F. Grabowski, P. Guerra-Mora, J.R. Guo, C. Guo, X. Gupta, H. He, S. Heijne, M. Heinemann, S. Hogrebe, A. Huang, Z. Iskander-Rizk, S. Iyer, L.M. Jahan, Y. James, A.S. Joel, E. Joffroy, B. Jégousse, C. Kambondo, G. Karnati, P. Kaya, C. Ke, A. Kelly, D. Kickert, R. Kidibule, P.E. Kieselmann, J.P. Kim, H.J. Kitazawa, T. Lamberts, A. Li, Y. Liang, H. Linn, S.N. Litfin, T. Liusuo, W. Lygirou, V. Mahato, A.K. Mai, Z.-M. Major, R.W. Mali, S. Mallis, P. Mao, W. Marvin-Dowle, K. Mason, L.D. Merideth, B. Merino-Plaza, M.J. Merlaen, B. Messina, R. Mishra, A.K. Muhammad, J. Musinguzi, C. Nanou, A. Naqash, A. Nguyen, J.T. Nguyen, T.T.H. Ni, D. Nida Notcovich, S. Ohst, B. Ollivier, Q.R. Osses, D.F. Peng, X. Plantinga, A. Pulia, M. Rafiq, M. Raman, A. Raucher-Chéné Rawski, R. Ray, A. Razak, L.A. Rudolf, K. Rusch, P. Sadoine, M.L. Schmidt, A. Schurr, R. Searles, S. Sharma, S. Sheehan, B. Shi, C. Shohayeb, B. Sommerlad, A. Strehlow, J. Sun, X. Sundar, R. Taherzadeh, G. Tahir, N.D.M. Tang, J. Testa, J. Tian, Z. Tingting, Q. Verheijen, G.P. Vickstrom, C. Wang, T. Wang, X. Wang, Z. Wei, P. Wilson, A. Wyart Yassine, A.-A. Yousefzadeh, A. Zare, A. Zeng, Z. Zhang, C. Zhang, H. Zhang, L. Zhang, T. Zhang, W. Zhang, Z. Zhou, J. Zhu, D. Adamo, V. Adeyemo, A.A. Aggelidou, M. Al-Owaifeer, A.M. Al-Riyami, A.Z. Alzghari, S.K. Andersen, V. Angus, K. Asaduzzaman, M. Asady, H. Ato, D. Bai, X. Baines, R.L. Ballantyne, M. Ban, B. Beck, J. Ben-Nafa, W. Black, E. Blancher, A. Blankstein, R. Bodagh, N. Borges, P. Brooks, A. Brox-Ponce, J. Brunetti, A. Canham, C.D. Carninci, P. Carvajal, R. Chang, S.C. Chao, J. Chatterjee, P. Chen, H. Chen, L. Chen, Y.-C. Chhatriwalla, A.K. Chikowe, I. Chuang, T.-J. Collevatti, R.G. Cornejo, D.A.V. Cuenda, A. Dao, M. Dauga, D. Deng, Z. Devkota, K. Doan, L.V. Elewa, Y.H.A. Fan, D. Faruk, M. Feifei, S. Ferguson, T.S. Fleres, F. Foster, E.J. Foster, S. Furer, T. Gao, Y. Garcia-Rivera, E.J. Gazdar, A. George, R.B. Ghosh, S. Gianchecchi, E. Gleason, J.M. Hackshaw, A. Hall, A. Hall, R. Harper, P. Hogg, W.E. Huang, G. Hunter, K.E. Ijzerman, A.P. Jesus, C. Jian, G. Lewis, J.S., Jr. Kanj, S.S. Kaur, H. Kelly, S. Kheir, F. 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Zaritsky, A. Zhang, Y. Zhao, H. Zuckerman, H. Lyu, R. Pullan, W. RELISH Consortium
- Abstract
Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical science. © The Author(s) 2019. Published by Oxford University Press.
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- 2019
205. Early Interstitial Lung Disease in Familial Pulmonary Fibrosis
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Rosas, Ivan O., Ren, Ping, Avila, Nilo A., Chow, Catherine K., Franks, Teri J., Travis, William D., McCoy, Philip J., Jr., May, Rose M., Wu, Hai-Ping, Nguyen, Dao M., Arcos-Burgos, Mauricio, MacDonald, Sandra D., and Gochuico, Bernadette R.
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- 2007
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206. Lung Cysts, Spontaneous Pneumothorax, and Genetic Associations in 89 Families with Birt-Hogg-Dubé Syndrome
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Toro, Jorge R., Pautler, Stephen E., Stewart, Laveta, Glenn, Gladys M., Weinreich, Michael, Toure, Ousmane, Wei, Ming-Hui, Schmidt, Laura S., Davis, Lewis, Zbar, Berton, Choyke, Peter, Steinberg, Seth M., Nguyen, Dao M., and Linehan, Marston W.
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- 2007
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207. OGG1 co-inhibition antagonizes the tumor-inhibitory effects of targeting MTH1
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Eric T. Kool, Nisha Sharma, Govindi J. Samaranayake, Dao M. Nguyen, Priyamvada Rai, Laura Misiara, Yu Ki Tahara, and Ling Zhang
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p53 ,0301 basic medicine ,Senescence ,senescence ,DNA Repair ,DNA repair ,Clinical Biochemistry ,Biochemistry ,oxidative DNA damage ,DNA Glycosylases ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Neoplasms ,Animals ,Humans ,lcsh:QH301-705.5 ,chemistry.chemical_classification ,lcsh:R5-920 ,MTH1 inhibition ,Organic Chemistry ,OGG1 inhibition ,Base excision repair ,Phosphoric Monoester Hydrolases ,lung cancer ,genomic DNA ,DNA Repair Enzymes ,030104 developmental biology ,Enzyme ,lcsh:Biology (General) ,chemistry ,DNA glycosylase ,Cancer cell ,Cancer research ,lcsh:Medicine (General) ,030217 neurology & neurosurgery ,DNA ,Research Paper ,DNA Damage - Abstract
Cancer cells develop protective adaptations against oxidative DNA damage, providing a strong rationale for targeting DNA repair proteins. There has been a high degree of recent interest in inhibiting the mammalian Nudix pyrophosphatase MutT Homolog 1 (MTH1). MTH1 degrades 8-oxo-dGTP, thus limiting its incorporation into genomic DNA. MTH1 inhibition has variously been shown to induce genomic 8-oxo-dG elevation, genotoxic strand breaks in p53-functional cells, and tumor-inhibitory outcomes. Genomically incorporated 8-oxo-dG is excised by the base excision repair enzyme, 8-oxo-dG glycosylase 1 (OGG1). Thus, OGG1 inhibitors have been developed with the idea that their combination with MTH1 inhibitors will have anti-tumor effects by increasing genomic oxidative DNA damage. However, contradictory to this idea, we found that human lung adenocarcinoma with low OGG1 and MTH1 were robustly represented in patient datasets. Furthermore, OGG1 co-depletion mitigated the extent of DNA strand breaks and cellular senescence in MTH1-depleted p53-wildtype lung adenocarcinoma cells. Similarly, shMTH1-transduced cells were less sensitive to the OGG1 inhibitor, SU0268, than shGFP-transduced counterparts. Although the dual OGG1/MTH1 inhibitor, SU0383, induced greater cytotoxicity than equivalent combined or single doses of its parent scaffold MTH1 and OGG1 inhibitors, IACS-4759 and SU0268, this effect was only observed at the highest concentration assessed. Collectively, using both genetic depletion as well as small molecule inhibitors, our findings suggest that OGG1/MTH1 co-inhibition is unlikely to yield significant tumor-suppressive benefit. Instead such co-inhibition may exert tumor-protective effects by preventing base excision repair-induced DNA nicks and p53 induction, thus potentially conferring a survival advantage to the treated tumors., Graphical abstract Image 1, Highlights • Low MTH1/low OGG1 tumors are robustly represented in patient lung adenocarcinoma datasets but low MTH1/high OGG1 are not. • Co-depletion of OGG1 in lung adenocarcinoma cells mitigates shMTH1-induced DNA strand breaks and p53-induced senescence. • p53-null tumor cells have lower OGG1 vs. wt p53 counterparts and are more resistant to MTH1 loss-induced anti-tumor effects. • Pharmacologic co-inhibition of OGG1 and MTH1 does not enhance cytotoxicity over the respective single inhibitors.
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- 2021
208. Listeria monocytogenes in platelets: a case report
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Guevara, Ramon E., Tormey, Michael P., Nguyen, Dao M., and Mascola, Laurene
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- 2006
209. Novel Molecular Targeted Therapy for Esophageal Cancer
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SCHRUMP, DAVID S. and NGUYEN, DAO M.
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- 2005
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210. The selective epidermal growth factor receptor tyrosine kinase inhibitor PD153035 suppresses expression of prometastasis phenotypes in malignant pleural mesothelioma cells in vitro
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Cole, George W., Jr, Alleva, Annette M., Reddy, Rishindra M., Maxhimer, Justin B., Zuo, JingTong, Schrump, David S., and Nguyen, Dao M.
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- 2005
211. Induction of apoptosis of lung and esophageal cancer cells treated with the combination of histone deacetylase inhibitor (trichostatin A) and protein kinase C inhibitor (calphostin C)
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Maxhimer, Justin B., Reddy, Rishindra M., Zuo, Jingtong, Cole, George W., Jr, Schrump, David S., and Nguyen, Dao M.
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- 2005
212. Large deformation of living cells using laser traps
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Lim, C.T., Dao, M., Suresh, S., Sow, C.H., and Chew, K.T.
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- 2004
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213. Growth factor receptors as targets for lung cancer therapy
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Nguyen, Dao M and Schrump, David S
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- 2004
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214. Virtual bronchoscopy for evaluation of airway disease
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Finkelstein, Steven E., Summers, Ronald M., Nguyen, Dao M., and Schrump, David S.
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- 2004
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215. Large expert-curated database for benchmarking document similarity detection in biomedical literature search
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Brown, P., Zhou, Y., Tan, A. -C., El-Esawi, M. A., Liehr, T., Blanck, O., Gladue, D. P., Almeida, G. M. F., Cernava, T., Sorzano, C. O., Yeung, A. W. K., Engel, M. S., Chandrasekaran, A. R., Muth, T., Staege, M. S., Daulatabad, S. V., Widera, D., Zhang, J., Meule, A., Honjo, K., Pourret, O., Yin, C. -C., Zhang, Z., Cascella, M., Flegel, W. A., Goodyear, C. S., van Raaij, M. J., Bukowy-Bieryllo, Z., Campana, L. G., Kurniawan, N. A., Lalaouna, D., Huttner, F. J., Ammerman, B. A., Ehret, F., Cobine, P. A., Tan, E. -C., Han, H., Xia, W., Mccrum, C., Dings, R. P. M., Marinello, F., Nilsson, H., Nixon, B., Voskarides, K., Yang, L., Costa, V. D., Bengtsson-Palme, J., Bradshaw, W., Grimm, D. G., Kumar, N., Martis, E., Prieto, D., Sabnis, S. C., Amer, S. E. D. R., Liew, A. W. C., Perco, P., Rahimi, F., Riva, G., Zhang, C., Devkota, H. P., Ogami, K., Basharat, Z., Fierz, W., Siebers, R., Tan, K. H., Boehme, K. A., Brenneisen, P., Brown, J. A. L., Dalrymple, B. P., Harvey, D. J., Ng, G., Werten, S., Bleackley, M., Dai, Z., Dhariwal, R., Gelfer, Y., Hartmann, M. D., Miotla, P., Tamaian, R., Govender, P., Gurney-Champion, O. J., Kauppila, J. H., Zhang, X., Echeverria, N., Subhash, S., Sallmon, H., Tofani, M., Bae, T., Bosch, O., Cuiv, P. O., Danchin, A., Diouf, B., Eerola, T., Evangelou, E., Filipp, F., Klump, H., Kurgan, L., Smith, S. S., Terrier, O., Tuttle, N., Ascher, D. B., Janga, S. C., Schulte, L. N., Becker, D., Browngardt, C., Bush, S. J., Gaullier, G., Ide, K., Meseko, C., Werner, G. D. A., Zaucha, J., Al-Farha, A. A., Greenwald, N. F., Popoola, S. I., Rahman, S., Xu, J., Yang, S. Y., Hiroi, N., Alper, O. M., Baker, C. I., Bitzer, M., Chacko, G., Debrabant, B., Dixon, R., Forano, E., Gilliham, M., Kelly, S., Klempnauer, K. -H., Lidbury, B. A., Lin, M. Z., Lynch, I., Ma, W., Maibach, E. W., Mather, D. E., Nandakumar, K. S., Ohgami, R. S., Parchi, P., Tressoldi, P., Xue, Y., Armitage, C., Barraud, P., Chatzitheochari, S., Coelho, L. P., Diao, J., Doxey, A. C., Gobet, A., Hu, P., Kaiser, S., Mitchell, K. M., Salama, M. F., Shabalin, I. G., Song, H., Stevanovic, D., Yadollahpour, A., Zeng, E., Zinke, K., Alimba, C. G., Beyene, T. J., Cao, Z., Chan, S. S., Gatchell, M., Kleppe, A., Piotrowski, M., Torga, G., Woldesemayat, A. A., Cosacak, M. I., Haston, S., Ross, S. A., Williams, R., Wong, A., Abramowitz, M. K., Effiong, A., Lee, S., Abid, M. B., Agarabi, C., Alaux, C., Albrecht, D. R., Atkins, G. J., Beck, C. R., Bonvin, A. M. J. J., Bourke, E., Brand, T., Braun, R. J., Bull, J. A., Cardoso, P., Carter, D., Delahay, R. M., Ducommun, B., Duijf, P. H. G., Epp, T., Eskelinen, E. -L., Fallah, M., Farber, D. 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R., van de Mortel, T., Moss, W. N., Moultos, O. A., Mukherjee, M., Nakayama, K., Narayan, E., Navaratnarajah, Neumann, P. -A., Nie, J., Nie, Y., Niemeyer, F., Nolan, F., Nwaiwu, O., Oldenmenger, W. H., Olumayede, E., Ou, J., Pallebage-Gamarallage, M., Pearce, S. P., Pelkonen, T., Pelleri, M. C., Pereira, J. L., Pheko, M., Pinto, K. A., Piovesan, A., Pluess, M., Podolsky, I. M., Prescott, J., Qi, D., Qi, X., Raikou, V. D., Ranft, A., Rhodes, J., Rotge, J. -Y., Rowe, A. D., Saggar, M., Schuon, R. A., Shahid, S., Shalchyan, V., Shirvalkar, P., Shiryayev, O., Singh, J., Smout, M. J., Soares, A., Song, C., Srivastava, K., Srivastava, R. K., Sun, J., Szabo, A., Szymanski, W., Tai, C. N. P., Takeuchi, H., Tanadini-Lang, S., Tang, F., Tao, W., Theron, G., Tian, C. F., Tian, Y. -S., Tuttle, L. M., Valenti, A., Verlot, P., Walker, M., Wang, J., Welter, D., Winslade, M., Wu, D., Wu, Y. -R., Xiao, H., Xu, B., Xu, Z., Yang, D., Yang, M., Yankilevich, P., You, Y., Yu, C., Zhan, J., Zhang, G., Zhang, K., Zhang, T., Zhao, G., Zhao, J., Zhou, X., Zhu, Z., Ajani, P. A., Anazodo, U. C., Bagloee, S. A., Bail, K., Bar, I., Bathelt, J., Benkeser, D., Bernier, M. L., Blanchard, A. M., Boakye, D. W., Bonatsos, V., Boon, M. H., Bouboulis, G., Bromfield, E., Brown, J., Bul, K. C. M., Burton, K. J., Butkowski, E. G., Carroll, G., Chao, F., Charrier, E. E., Chen, Y. -C., Chenguang, Choi, J. R., Christoffersen, T., Comel, J. C., Cosse, C., Cui, Y., van Dessel, P., Dhaval, Diodato, D., Duffey, M., Dutt, A., Egea, L. G., El-Said, M., Faye, M., Fernandez-Fernandez, B., Foley, K. G., Founou, L. L., Fu, F., Gadelkareem, R. A., Galimov, E., Garip, G., Gemmill, A., Gouil, Q., Grey, J., Gridneva, Z., Grothe, M. J., Grebert, T., Guerrero, F., Guignard, L., Haenssgen, M. J., Hasler, D., Holgate, J. Y., Huang, A., Hulse-Kemp, A. M., Jean-Quartier, C., Jeon, S. -M., Jia, Y., Jutzeler, C., Kalatzis, P., Karim, M., Karsay, K., Keitel, A., Kempe, A., Keown, J. R., Khoo, C. M., Khwaja, N., Kievit, R. A., Kosanic, S., Koutoukidis, D. A., Kramer, P., Kumar, D., Kirag, N., Lanza, G., Le, T. D., Leem, J. W., Leightley, D., Leite, A., Lercher, L., Li, Y., Lim, R., Lima, L. R. A., Lin, L., Ling, T., Liu, Y., Liu, Z., Lu, Y., Lum, F. M., Luo, H., Machhi, J., Macleod, A., Macwan, I., Madala, H. R., Madani, N., de Maio, N., Makowiecki, K., Mallinson, D. J., Margelyte, R., Maria, C., Markonis, Y., Marsili, L., Mavoa, S., Mcwilliams, L., Megersa, M., Souto-Maior, C., Menichetti, J., Mercieca-Bebber, R., Miller, J. J., Minde, D. -P. M., Minges, A., Mishra, E., Mishra, V. R., Moores, C., Morrice, N., Moskalensky, A. E., Navarin, N., Negera, E., Nolet, P., Nordberg, A., Norden, R., Nowicki, J. P., Olova, N., Olszewski, P., Onzima, R., Pan, C. -L., Park, C., Park, D. I., Park, S., Patil, C. D., Pedro, S. A., Perry, S. R., Peter, J., Peterson, B. M., Pezzuolo, A., Pozdnyakov, I., Qian, S., Qin, L., Rafe, A., Raote, I., Raza, A., Rebl, H., Refai, O., Regan, T., Richa, T., Richardson, M. F., Robinson, K. R., Rossoni, L., Rouet, R., Safaei, S., Schneeberger, P. H. H., Schwotzer, D., Sebastian, A., Selinski, J., Seltmann, S., Sha, F., Shalev, N., Shang, J. -L., Singer, J., Singh, M., Smith, T., Solomon-Moore, E., Song, L., Soraggi, S., Stanley, R., Steckhan, N., Strobl, F., Subissi, L., Supriyanto, I., Surve, C. R., Suzuki, T., Syme, C., Sorelius, K., Tang, Y., Tantawy, M., Tennakoon, S., Teseo, S., Toelzer, C., Tomov, N., Tovar, M., Tran, L., Tripathi, S., Tuladhar, A. M., Ukubuiwe, A. C., Ung, C. O. L., Valgepea, K., Vatanparast, H., Vidal, A., Wang, Q., Watari, R., Webster, R., Wei, J., Wibowo, D., Wingenbach, T. S. H., Xavier, R. M., Xiao, S., Xiong, P., Xu, S., Yao, R., Yao, W., Yin, Q., Zaitsu, M., Zeineb, Z., Zhan, X. -Y., Zhang, R., Zhang, W., Zheng, S., Zhou, B., Ahmad, H., Akinwumi, S. A., Albery, G. F., Alhowimel, A., Ali, J., Alshehri, M., Alsuhaibani, M., Anikin, A., Azubuike, S. O., Bach-Mortensen, A., Baltiansky, L., Bartas, M., Belachew, K. Y., Bhardwaj, V., Binder, K., Bland, N. S., Boah, M., Bullen, B., Calabro', Giovanna Elisa, Callahan, T. J., Cao, B., Chalmers, K., Chang, W., Che, Z., Chen, A. T. Y., Chen, Z., Choi, Y., Chowdhury, M. A. K., Christensen, M. R., Cooke, R. S. C., Cottini, M., Covington, N. V., Cunningham, C., Delarocque, J., Devos, L., Dhar, A. R., Ding, K. -F., Dong, K., Dong, Z., Dreyer, N., Ekstrand, C., Fardet, T., Feleke, B. E., Feurer, T., Freitas, A., Gao, T., Gebremedhin, Giganti, F., Grabowski, P., Guerra-Mora, J. R., Guo, C., Guo, X., Gupta, H., He, S., Heijne, M., Heinemann, S., Hogrebe, A., Huang, Z., Iskander-Rizk, S., Iyer, L. M., Jahan, Y., James, A. S., Joel, E., Joffroy, B., Jegousse, C., Kambondo, G., Karnati, P., Kaya, C., Ke, A., Kelly, D., Kickert, R., Kidibule, P. E., Kieselmann, J. P., Kim, H. J., Kitazawa, T., Lamberts, A., Liang, H., Linn, S. N., Litfin, T., Liusuo, W., Lygirou, V., Mahato, A. K., Mai, Z. -M., Major, R. W., Mali, S., Mallis, P., Mao, W., Marvin-Dowle, K., Mason, L. D., Merideth, B., Merino-Plaza, M. J., Merlaen, B., Messina, R., Mishra, A. K., Muhammad, J., Musinguzi, C., Nanou, A., Naqash, A., Nguyen, J. T., Nguyen, T. T. H., Ni, D., Nida, Notcovich, S., Ohst, B., Ollivier, Q. R., Osses, D. F., Peng, X., Plantinga, A., Pulia, M., Rafiq, M., Raman, A., Raucher-Chene, Rawski, R., Ray, A., Razak, L. A., Rudolf, K., Rusch, P., Sadoine, M. L., Schmidt, A., Schurr, R., Searles, S., Sharma, S., Sheehan, B., Shi, C., Shohayeb, B., Sommerlad, A., Strehlow, J., Sun, X., Sundar, R., Taherzadeh, G., Tahir, N. D. M., Tang, J., Testa, J., Tian, Z., Tingting, Q., Verheijen, G. P., Vickstrom, C., Wang, T., Wang, X., Wang, Z., Wei, P., Wilson, A., Wyart, Yassine, A. -A., Yousefzadeh, A., Zare, A., Zeng, Z., Zhang, H., Zhou, J., Zhu, D., Adamo, V., Adeyemo, A. A., Aggelidou, M., Al-Owaifeer, A. M., Al-Riyami, A. Z., Alzghari, S. K., Andersen, V., Angus, K., Asaduzzaman, M., Asady, H., Ato, D., Bai, X., Baines, R. L., Ballantyne, M., Ban, B., Beck, J., Ben-Nafa, W., Black, E., Blancher, A., Blankstein, R., Bodagh, N., Borges, P., Brooks, A., Brox-Ponce, J., Brunetti, A., Canham, C. D., Carninci, P., Carvajal, R., Chang, S. C., Chao, J., Chatterjee, P., Chen, L., Chhatriwalla, A. K., Chikowe, I., Chuang, T. -J., Collevatti, R. G., Cornejo, D. A. V., Cuenda, A., Dao, M., Dauga, D., Deng, Z., Devkota, K., Doan, L. V., Elewa, Y. H. A., Fan, D., Faruk, M., Feifei, S., Ferguson, T. S., Fleres, F., Foster, E. J., Foster, S., Furer, T., Gao, Y., Garcia-Rivera, E. J., Gazdar, A., George, R. B., Ghosh, S., Gianchecchi, E., Gleason, J. M., Hackshaw, A., Hall, A., Hall, R., Harper, P., Hogg, W. E., Huang, G., Hunter, K. E., Ijzerman, A. P., Jesus, C., Jian, G., Lewis, J. S., Kanj, S. S., Kaur, H., Kheir, F., Kichatova, V. S., Kiyani, M., Klein, R., Kovesi, T., Kraschnewski, J. L., Kumar, A. P., Labutin, D., Lazo-Langner, A., Leclercq, G., Li, M., Li, Q., Li, T., Liao, W. -T., Liao, Z. -Y., Lin, J., Lizer, J., Lobreglio, G., Lowies, C., Lu, C., Majeed, H., Martin, A., Martinez-Sobrido, L., Meresh, E., Middelveen, M., Mohebbi, A., Mota, J., Mozaheb, Z., Muyaya, L., Nandhakumar, A., Ng, S. H. X., Obeidat, M., Oh, D. -H., Owais, M., Pace-Asciak, P., Panwar, A., Patterson, C., Penagos-Tabaree, F., Pianosi, P. T., Pinzi, V., Pridans, C., Psaroulaki, A., Pujala, R. K., Pulido-Arjona, L., Qi, P. -F., Rahman, P., Rai, N. K., Rassaf, T., Refardt, J., Ricciardi, Walter, Riess, O., Rovas, A., Sacks, F. M., Saleh, S., Sampson, C., Schmutz, A., Sepanski, R., Sharma, N., Spearman, P., Subramaniapillai, M., Swali, R., Tan, C. M., Tellechea, J. I., Thomas, L. -M., Tong, X., Vavvas, D. G., Veys, R., Vitriol, V., Wang, H. -D., Waugh, J., Webb, S. A., Williams, B. A., Workman, A. D., Xiang, T., Xie, L. -X., Xu, T., Yang, C., Yoon, J. G., Yuan, C. M., Zaritsky, A., Zhao, H., Zuckerman, H., Lyu, R., Pullan, W., Calabro G. E. (ORCID:0000-0003-0259-3797), and Ricciardi W. (ORCID:0000-0002-5655-688X)
- Abstract
Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical science.
- Published
- 2019
216. In utero and postnatal VX-770 administration rescues multiorgan disease in a ferret model of cystic fibrosis
- Author
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Onderzoek, Longziekten onderzoek 2, Child Health, Regenerative Medicine and Stem Cells, Sun, Xingshen, Yi, Yaling, Yan, Ziying, Rosen, Bradley H., Liang, Bo, Winter, Michael C., Evans, T. Idil Apak, Rotti, Pavana G., Yang, Yu, Gray, Jaimie S., Park, Soo Yeun, Zhou, Weihong, Zhang, Yulong, Moll, Shashanna R., Woody, Lisa, Tran, Dao M., Jiang, Licong, Vonk, Annelotte M., Beekman, Jeffrey M., Negulescu, Paul, Van Goor, Fred, Fiorino, Dennis F., Gibson-Corley, Katherine N., Engelhardt, John F., Onderzoek, Longziekten onderzoek 2, Child Health, Regenerative Medicine and Stem Cells, Sun, Xingshen, Yi, Yaling, Yan, Ziying, Rosen, Bradley H., Liang, Bo, Winter, Michael C., Evans, T. Idil Apak, Rotti, Pavana G., Yang, Yu, Gray, Jaimie S., Park, Soo Yeun, Zhou, Weihong, Zhang, Yulong, Moll, Shashanna R., Woody, Lisa, Tran, Dao M., Jiang, Licong, Vonk, Annelotte M., Beekman, Jeffrey M., Negulescu, Paul, Van Goor, Fred, Fiorino, Dennis F., Gibson-Corley, Katherine N., and Engelhardt, John F.
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- 2019
217. Cisplatin enhances apoptosis induced by a tumor-selective adenovirus expressing tumor necrosis factor–related apoptosis-inducing ligand
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Reddy, Rishindra M., Tsai, Wilson S., Ziauddin, M. Firdos, Zuo, JingTong, Cole, George W., Jr, Maxhimer, Justin B., Fang, BingLiang, Schrump, David S., and Nguyen, Dao M.
- Published
- 2004
218. Potentiation of paclitaxel cytotoxicity in lung and esophageal cancer cells by pharmacologic inhibition of the phosphoinositide 3-kinase/protein kinase B (Akt)–mediated signaling pathway
- Author
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Nguyen, Dao M., Chen, G. Aaron, Reddy, Rishindra, Tsai, Wilson, Schrump, William D., Cole, George, Jr, and Schrump, David S.
- Published
- 2004
219. Comparative Evaluation of Super High-Resolution CT Scan and Virtual Bronchoscopy for the Detection of Tracheobronchial Malignancies*
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Finkelstein, Steven E., Schrump, David S., Nguyen, Dao M., Hewitt, Stephen M., Kunst, Tricia F., and Summers, Ronald M.
- Published
- 2003
220. Enhancement of depsipeptide-mediated apoptosis of lung or esophageal cancer cells by flavopiridol: Activation of the mitochondria-dependent death-signaling pathway
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Nguyen, Dao M., Schrump, William D., Tsai, Wilson S., Chen, Aaron, Stewart, John H., IV, Steiner, Federico, and Schrump, David S.
- Published
- 2003
221. A 9 cm robotic thymectomy and pericardial repair case report
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Dao M. Nguyen, Nestor Villamizar, and Karishma Kodia
- Subjects
Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,business.industry ,pericardial resection ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Medicine (miscellaneous) ,thymoma ,Surgery ,Thymectomy ,surgical procedures, operative ,Oncology ,pericardial reconstruction ,case report ,Medicine ,Radiology, Nuclear Medicine and imaging ,Robotic thymectomy ,Cardiology and Cardiovascular Medicine ,business - Abstract
In the modern surgical era, improved technology has allowed for the increasing use of the robotic platform for thymoma resection. Historically, tumors >5 cm were deemed inappropriate for minimally invasive approaches; thoracic surgeons, however, have become adept with performing increasingly complex thymectomies using minimally invasive techniques. Excision of large thymomas using the robotic platform is no longer considered a rare event, however few publications have described the use of minimally invasive surgery for en bloc excision of the pericardium with mesh reconstruction. We present a case of an asymptomatic, incidentally discovered 9 cm thymoma involving the pericardium and right lung upper lobe that was resected via bilateral robotic-assisted thymectomy en bloc with wedge resection and pericardial resection with mesh reconstruction. The case highlights the use of the robotic platform to avoid a conversion to open thymectomy. The patient was discharged home on postoperative day 3 with minimal pain and narcotic requirement. We aim to contribute to the existing literature supporting the use of the robotic platform during complex thymectomy. The associated video presentation serves as a visual instructional guide for the thymoma resection, en bloc with the right upper lobe and pericardium and the pericardial reconstruction. This minimally invasive technique has been associated with shorter hospital stay, reduced pain and faster recovery.
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- 2020
222. Key highlights of the robotic surgical session including dissection of thymic tissue, right lung wedge resection, pericardial resection, pericardial defect repair, and pericardial membrane fenestration
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Dao M. Nguyen, Karishma Kodia, and Nestor Villamizar
- Subjects
medicine.medical_specialty ,Lung ,business.industry ,Dissection (medical) ,medicine.disease ,Surgery ,Resection ,Pericardial defect ,Thymic Tissue ,medicine.anatomical_structure ,Materials Chemistry ,medicine ,Fenestration ,business ,Wedge resection (lung) - Published
- 2020
223. Usefulness of chest ultrasonography in the management of acute respiratory failure in the emergency room
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Silva, S, Dao, M, Biendel, C, Riu, B, Ruiz, J, Bataille, B, Bedel, J, Genestal, M, and Fourcade, O
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- 2011
- Full Text
- View/download PDF
224. Phase I Study of Sequential Deoxyazacytidine/Depsipeptide Infusion in Patients with Malignancies Involving Lungs or Pleura
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Schrump, David S., Nguyen, Dao M., Kunst, Tricia F., Hancox, Ana, Figg, William D., Steinberg, Seth M., Pishchik, Vitaliy, and Becerra, Yvonne
- Published
- 2002
225. Incorporation and integration of implanted myogenic and stem cells into native myocardial fibers: Anatomic basis for functional improvements
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Chedrawy, Edgar G., Wang, Jih-Shiuan, Nguyen, Dao M., Shum-Tim, Dominique, and Chiu, Ray C. J.
- Published
- 2002
226. Virtual bronchoscopy for evaluation of malignant tumors of the thorax
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Finkelstein, Steven E., Summers, Ronald M., Nguyen, Dao M., Stewart, John H., IV, Tretler, Jean A., and Schrump, David S.
- Published
- 2002
227. Modulation of p53, ErbB1, ErbB2, and Raf-1 Expression in Lung Cancer Cells by Depsipeptide FR901228
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Yu, Xiaodan, Guo, Z. Sheng, Marcu, Monica G., Neckers, Len, Nguyen, Dao M., Chen, G. Aaron, and Schrump, David S.
- Published
- 2002
228. Pharmacokinetics of paclitaxel administered by hyperthermic retrograde isolated lung perfusion techniques
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Schrump, David S., Zhai, Suoping, Nguyen, Dao M., Weiser, Todd S., Fisher, Bradley A., Terrill, Richard E., Flynn, Bernard M., Duray, Paul H., and Figg, William D.
- Published
- 2002
229. Induction of apoptosis in malignant pleural mesothelioma cells by activation of the Fas (Apo-1/CD95) death-signal pathway
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Stewart, John H., IV, Nguyen, Dao M., Chen, G. Aaron, Schrump, David S., and Rusch, Sponsor: Valerie
- Published
- 2002
230. Scooter Injuries: A New Pediatric Morbidity
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Abbott, Myles B., Hoffinger, Scott A., Nguyen, Dao M., and Weintraub, Dana L.
- Published
- 2001
231. Some critical experiments on the strain-rate sensitivity of nanocrystalline nickel
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Schwaiger, R, Moser, B, Dao, M, Chollacoop, N, and Suresh, S
- Published
- 2003
- Full Text
- View/download PDF
232. Depth-sensing instrumented indentation with dual sharp indenters
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Chollacoop, N., Dao, M., and Suresh, S.
- Published
- 2003
- Full Text
- View/download PDF
233. Mechanics of the human red blood cell deformed by optical tweezers
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Dao, M., Lim, C.T., and Suresh, S.
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- 2003
- Full Text
- View/download PDF
234. Arsenic Attenuates GLI Signaling, Increasing or Decreasing its Transcriptional Program in a Context-Dependent Manner
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Camilla Giambelli, Jun Long, Ke Jin, Lily Wang, Priyamvada Rai, Baolin Wang, Bach Ardalan, Bo Tang, Mohammad Athar, Dao M. Nguyen, Anthony J. Capobianco, Pochi R. Subbarayan, Zhiqiang Wang, Bin Li, Emily F. Winterbottom, David J. Robbins, and Dennis Liang Fei
- Subjects
inorganic chemicals ,0301 basic medicine ,Transcription, Genetic ,Mice, Nude ,Repressor ,chemistry.chemical_element ,Biology ,Zinc Finger Protein GLI1 ,Arsenic ,Mice ,03 medical and health sciences ,Animals ,Humans ,Hedgehog ,Transcription factor ,Pharmacology ,integumentary system ,Oncogene ,Effector ,Activator (genetics) ,Articles ,HCT116 Cells ,Xenograft Model Antitumor Assays ,Cell biology ,030104 developmental biology ,Biochemistry ,chemistry ,NIH 3T3 Cells ,Molecular Medicine ,Female ,Signal transduction ,Signal Transduction ,Transcription Factors - Abstract
The metalloid arsenic is a worldwide environmental toxicant, exposure to which is associated with many adverse outcomes. Arsenic is also an effective therapeutic agent in certain disease settings. Arsenic was recently shown to regulate the activity of the Hedgehog (HH) signal transduction pathway, and this regulation of HH signaling was proposed to be responsible for a subset of arsenic’s biologic effects. Surprisingly, these separate reports proposed contradictory activities for arsenic, as either an agonist or antagonist of HH signaling. Here we provide in vitro and in vivo evidence that arsenic acts as a modulator of the activity of the HH effector protein glioma-associated oncogene family zinc finger (GLI), activating or inhibiting GLI activity in a context-dependent manner. This arsenic-induced modulation of HH signaling is observed in cultured cells, patients with colorectal cancer who have received arsenic-based therapy, and a mouse colorectal cancer xenograft model. Our results show that arsenic activates GLI signaling when the intrinsic GLI activity is low but inhibits signaling in the presence of high-level GLI activity. Furthermore, we show that this modulation occurs downstream of primary cilia, evidenced by experiments in suppressor of fused homolog (SUFU) deficient cells. Combining our findings with previous reports, we present an inclusive model in which arsenic plays dual roles in GLI signaling modulation: when GLIs are primarily in their repressor form, arsenic antagonizes their repression capacity, leading to low-level GLI activation, but when GLIs are primarily in their activator form, arsenic attenuates their activity.
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- 2015
235. 'One-stop shop' tumor tattooing and sentinel lymph node mapping: A new paradigm for lung cancer therapy
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Nestor Villamizar and Dao M. Nguyen
- Subjects
Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Lung Neoplasms ,Tattooing ,Sentinel Lymph Node Biopsy ,business.industry ,General surgery ,030204 cardiovascular system & hematology ,medicine.disease ,Article ,Sentinel lymph node mapping ,03 medical and health sciences ,One stop shop ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Humans ,Medicine ,Surgery ,Sentinel Lymph Node ,Cardiology and Cardiovascular Medicine ,business ,Lung cancer - Published
- 2017
236. Outcomes of a lung cancer screening program in a Hispanic urban population: The University of Miami experience
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Jessica MacIntyre, Marie Jeannette Jeanette Charles, Richa Dawar, Tisdrey Torres, Kunal Gawri, Sophie Torrents, Raphael Yechieli, Nestor Villamizar, Dao M. Nguyen, Gilberto Lopes, and Estelamari Rodriguez
- Subjects
Oncology ,Cancer Research ,education.field_of_study ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Population ,Computed tomography ,medicine.disease ,Internal medicine ,medicine ,National Lung Screening Trial ,education ,business ,Lung cancer ,Lung cancer screening - Abstract
e19011 Background: The National Lung Screening Trial (NLST) revealed a 20% reduction in lung cancer (LC) mortality when low-dose computed tomography (LDCT) was utilized for LC screening vs chest radiography. NLST participants were predominantly Non-Hispanic Whites, with only 1.8% Hispanics. The goal of our study was to investigate the attributes of a LC screening program in a largely Hispanic urban population and compare with NLST. Methods: We performed a retrospective analysis of 421 consecutive cases who underwent LDCT screening from 2016-2019 at University of Miami (UM), with similar inclusion criteria as the NLST. Demographic characteristics, smoking status, lung RADS, LC detection and compliance were examined & compared with NLST cohort using summary statistics and χ2 tests for categorical variables. Results: Demographic and smoking characteristics of the UM cohort didn’t resemble those of NLST LDCT cohort. UM cohort had a different racial and ethnic profile, with a higher percentage of Hispanics (47.3% vs 1.8%) and African Americans (15% vs 4.5%) in the UM cohort vs NLST cohort respectively (p < 0.001). UM cohort generally had lesser smoking intensity, and significantly fewer active smokers when compared to the NSLT cohort; 38.5% vs 48.1% respectively. The proportion of positive LDCT screens (Lung-RADS Class 3 or 4) in the UM cohort (14.1%) was almost similar to the NLST cohort (13.7%) (p = 0.81). The UM cohort had a higher LC detection rate (3.3%) than the NLST cohort (1.1%) (p < 0.001). In keeping with goals of screening, both cohorts had 50% or more LC cases detected at an early curable stage. Overall patient adherence to screening guidelines was more than 90% in NLST cohort; whereas almost a quarter of referred patients in UM cohort didn’t show for their initial decision-making visit and only 45% completed two or more scans. Conclusions: Our LDCT screening program was based in a Hispanic urban location (UM) with 47.3% Hispanics. Compared to NLST LDCT arm, the UM cohort had fewer active smokers, lighter smoking history, a more diverse population, somewhat higher LC detection rate, weaker adherence to screening related visits. More data is needed to understand obstacles to compliance with screening in minority populations.
- Published
- 2020
237. SEQUENCE-DEPENDENT ENHANCEMENT OF PACLITAXEL TOXICITY IN NON-SMALL CELL LUNG CANCER BY 17-ALLYLAMINO 17-DEMETHOXYGELDANAMYCIN
- Author
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Nguyen, Dao M., Chen, Aaron, Mixon, Arnold, and Schrump, David S.
- Published
- 1999
238. Traumatic Rupture of the Descending Thoracic Aorta Associated with Severe Pulmonary Contusion: Requirement of Full Cardiopulmonary Bypass for Life Support during Surgical Repair
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Nguyen, Dao M., Hill, Andrew B., Chughtai, Talat, Robinson, Richard, and Mulder, David S.
- Published
- 1999
239. Adenovirus-Mediated p53 Gene Transfer in Advanced Non-Small-Cell Lung Cancer
- Author
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Swisher, Stephen G., Roth, Jack A., Nemunaitis, John, Lawrence, David D., Kemp, Bonnie L., Carrasco, Cesar H., Connors, Dee G., El-Naggar, Adel K., Fossella, Frank, Glisson, Bonnie S., Hong, Waun K., Khuri, Fadlo R., Kurie, Jonathan M., Lee, Jack J., Lee, Jin S., Mack, Michael, Merritt, James A., Nguyen, Dao M., Nesbitt, Jonathan C., Perez-Soler, Roman, Pisters, Katherine M. W., Putnam, Joe B., Jr, Richli, William R., Savin, Michael, Schrump, David S., Shin, Dong M., Shulkin, Allan, Walsh, Garrett L., Wait, Juliette, Weill, David, and Waugh, M. Kimberly A.
- Published
- 1999
240. Lobectomy with ECMO Support in an Infant Who Developed Pulmonary Interstitial Emphysema Following Repair of Hypoplastic Aortic Arch
- Author
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Magarakis, Michael, Nguyen, Dao M., Macias, Alejandro E., and Rosenkranz, Eliot R.
- Subjects
Respiratory Distress Syndrome, Newborn ,Extracorporeal Membrane Oxygenation ,Pulmonary Emphysema ,Aorta, Thoracic/Abnormalities/Surgery ,Infant, Newborn, Diseases - Abstract
Pulmonary interstitial emphysema (PIE) is a common problem in premature neonates with respiratory distress syndrome. This condition is often related to barotrauma caused by mechanical ventilation or continuous positive airway pressure applied to low birth weight neonates. The clinical diagnosis can be challenging. However, after proper diagnosis, several interventions are available for successful management. We describe an infant who developed severe PIE with recurrent pneumothoraces and development of a persistent bronchopleural fistula shortly after repair of a hypoplastic aortic arch and description of successful lobectomy with the assistance of extracorporeal support (ECMO).
- Published
- 2018
241. Increased MTH1-specific 8-oxodGTPase activity is a hallmark of cancer in colon, lung and pancreatic tissue
- Author
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Dao M. Nguyen, Clara I. Troccoli, Priyamvada Rai, Eric T. Kool, David J. Robbins, Annie E. Bowles, Nipun B. Merchant, Debin Ji, Michael G. Mohsen, Nagaraj S. Nagathihalli, James M. Ford, Makelle L. Gardiner, and Lisa A. McPherson
- Subjects
Senescence ,Lung Neoplasms ,DNA repair ,DNA damage ,Colorectal cancer ,Cellular homeostasis ,Biology ,Biochemistry ,Article ,Gene Knockout Techniques ,03 medical and health sciences ,0302 clinical medicine ,Western blot ,Cell Line, Tumor ,Neoplasms ,medicine ,Humans ,Molecular Biology ,030304 developmental biology ,0303 health sciences ,medicine.diagnostic_test ,Cancer ,Cell Biology ,medicine.disease ,Phosphoric Monoester Hydrolases ,Pancreatic Neoplasms ,DNA Repair Enzymes ,030220 oncology & carcinogenesis ,Colonic Neoplasms ,Cancer cell ,Cancer research - Abstract
Cellular homeostasis is dependent on a balance between DNA damage and DNA repair mechanisms. Cells are constantly assaulted by both exogenous and endogenous stimuli leading to high levels of reactive oxygen species (ROS) that cause oxidation of the nucleotide dGTP to 8-oxodGTP. If this base is incorporated into DNA and goes unrepaired, it can result in G > T transversions, leading to genomic DNA damage. MutT Homolog 1 (MTH1) is a nucleoside diphosphate X (Nudix) pyrophosphatase that can remove 8-oxodGTP from the nucleotide pool before it is incorporated into DNA by hydrolyzing it into 8-oxodGMP. MTH1 expression has been shown to be elevated in many cancer cells and is thought to be a survival mechanism by which a cancer cell can stave off the effects of high ROS that can result in cell senescence or death. It has recently become a target of interest in cancer because it is thought that inhibiting MTH1 can increase genotoxic damage and cytotoxicity. Determining the role of MTH1 in normal and cancer cells is confounded by an inability to reliably and directly measure its native enzymatic activity. We have used the chimeric A TP- r eleasing g uanine- o xidized (ARGO) probe that combines 8-oxodGTP and ATP to measure MTH1 enzymatic activity in colorectal cancer (CRC), non-small cell lung cancer (NSCLC) and pancreatic ductal adenocarcinoma (PDAC) along with patient-matched normal tissue. MTH1 8-oxodGTPase activity is significantly increased in tumors across all three tissue types, indicating that MTH1 is a marker of cancer. MTH1 activity measured by ARGO assay was compared to mRNA and protein expression measured by RT-qPCR and Western blot in the CRC tissue pairs, revealing a positive correlation between ARGO assay and Western blot, but little correlation with RT-qPCR in these samples. The adoption of the ARGO assay will help in establishing the level of MTH1 activity in model systems and in assessing the effects of MTH1 modulation in the treatment of cancer.
- Published
- 2019
242. MBRS-64. SURPRISING ROLE FOR WNT SIGNALING IN SONIC HEDGEHOG DRIVEN MEDULLOBLASTOMA
- Author
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Lina Pednekar, Nagi G. Ayad, Priyamvada Rai, Clara Penas, Dao M. Nguyen, David J. Robbins, Carmen Rodríguez, Ethan Lee, Nadji Mehrdad, Vanesa Martín, William A. Weiss, Bin Li, Jezabel Rodriguez-Blanco, Jun Long, and Anthony J. Capobianco
- Subjects
Medulloblastoma ,Cancer Research ,biology ,Wnt signaling pathway ,Cancer ,medicine.disease ,Abstracts ,Oncology ,Cancer research ,medicine ,biology.protein ,Neurology (clinical) ,Sonic hedgehog ,Signal transduction - Abstract
The classification of specific cancers into distinct subgroups, based on emerging genomic technologies, has ushered in a new era of targeted therapeutics and companion diagnostics. This promise, however, is inconsistent with a model in which the growth of solid tumors, and their resistance to various chemotherapeutics, is driven by a small number of tumor-propagating cells whose transcriptome is unlikely to be captured by these technologies. We isolated such tumor propagating cells from a mouse model for SONIC HEDGEHOG (SHH)-subgroup medulloblastoma. Medulloblastoma sphere cultures were enriched for the medulloblastoma progenitor marker SOX2, resistant to SHH inhibitors, and formed tumors in vivo. Surprisingly, these cultures, and their ability to self-renew were WNT-dependent. We show that Trp53 loss in these sphere cultures activated canonical WNT signaling and a small molecule WNT inhibitor was able to reduce the propagation and growth of SHH-subgroup medulloblastoma in vivo, in an on-target manner, leading to increased survival. Our results suggest that the tumor propagating cells driving the growth of bulk SHH-dependent medulloblastoma are themselves WNT dependent. Further, these results suggest WNT pathway inhibition as a novel therapeutic strategy to treat TRP53 deficient SHH-subgroup medulloblastoma patients, for whom few therapeutic options exist.
- Published
- 2018
243. High Frequency of the PNPLA3 rs738409 [G] Single Nucleotide Polymorphism in Hmong Individuals as a Potential Basis for Predisposition to Chronic Liver Disease1
- Author
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Tepper, Clifford G., Dang, Julie H.T., Stewart, Susan L., Fang, Dao M., Wong, Kimberly A., Liu, Stephenie Y., Davis, Ryan R., Dao, Doan Y., Gregg, Jeffrey P., Török, Natalie J., and Chen, Moon S.
- Subjects
Adult ,Liver Cirrhosis ,Male ,Asian ,Genotype ,Incidence ,Membrane Proteins ,Lipase ,Middle Aged ,Prognosis ,Polymorphism, Single Nucleotide ,digestive system diseases ,Article ,California ,Young Adult ,Chronic Disease ,Humans ,Female ,Genetic Predisposition to Disease ,Aged ,Follow-Up Studies - Abstract
An exploratory study was performed to determine the prevalence of the patatin-like phospholipase domain-containing protein 3 (PNPLA3) rs78409 [G] allele among the Hmong as a risk factor for nonalcoholic fatty liver disease (NAFLD). NAFLD/nonalcoholic steatohepatitis is the world's most common chronic liver disease and is expected to replace viral hepatitis as the leading cause of cirrhosis and potential precursor to hepatocellular carcinoma (HCC). Of all populations in California, the Hmong experience the highest risk of death from HCC and the highest prevalence of metabolic syndrome risk factors among Asians that predispose them to NAFLD. Here a genetic explanation was sought for the high rates of chronic liver disease among the Hmong. The literature pointed to the PNPLA3 rs738409 [G] allele as a potential genetic culprit.Cell-free DNA was isolated from 26 serum samples previously collected in community settings. Quantitative polymerase chain reaction-based single-nucleotide polymorphism (SNP) genotyping was performed with a validated TaqMan SNP genotyping assay, and results were analyzed with TaqMan Genotyper software.The PNPLA3 rs738409 [CG] variant occurred at a frequency of 0.46 (12 of 26; 95% confidence interval, 0.27-0.67). This carrier rate would rank the Hmong as the third highest population in the 1000 Genomes Project.Although this small sample size limits the generalizability, the high frequency rates of this allele along with the presence of metabolic syndrome risk factors warrant further studies into the etiology of NAFLD among the Hmong. Cancer 2018;124:1583-9. © 2018 American Cancer Society.
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- 2018
244. Lobectomy with ECMO Support in an Infant Who Developed Pulmonary Interstitial Emphysema Following Repair of Hypoplastic Aortic Arch
- Author
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Eliot Rosenkranz, Alejandro E. Macias, Dao M. Nguyen, and Michael Magarakis
- Subjects
lcsh:Diseases of the circulatory (Cardiovascular) system ,medicine.medical_specialty ,medicine.medical_treatment ,lcsh:Surgery ,Bronchopleural fistula ,Case Report ,Infant, Newborn, Diseases ,03 medical and health sciences ,Extracorporeal Membrane Oxygenation ,0302 clinical medicine ,030225 pediatrics ,medicine.artery ,medicine ,Extracorporeal membrane oxygenation ,Continuous positive airway pressure ,Mechanical ventilation ,Respiratory Distress Syndrome, Newborn ,Aorta ,Respiratory distress ,business.industry ,lcsh:RD1-811 ,General Medicine ,Pulmonary interstitial emphysema ,medicine.disease ,Surgery ,Pulmonary Emphysema ,030228 respiratory system ,lcsh:RC666-701 ,Aorta, Thoracic/Abnormalities/Surgery ,Hypoplastic aortic arch ,Cardiology and Cardiovascular Medicine ,business - Abstract
Pulmonary interstitial emphysema (PIE) is a common problem in premature neonates with respiratory distress syndrome. This condition is often related to barotrauma caused by mechanical ventilation or continuous positive airway pressure applied to low birth weight neonates. The clinical diagnosis can be challenging. However, after proper diagnosis, several interventions are available for successful management. We describe an infant who developed severe PIE with recurrent pneumothoraces and development of a persistent bronchopleural fistula shortly after repair of a hypoplastic aortic arch and description of successful lobectomy with the assistance of extracorporeal support (ECMO).
- Published
- 2018
245. Efficacité des échanges plasmatiques et des immuno-absorptions dans les syndromes néphrotiques idiopathiques réfractaires de l’adulte sur reins natifs : étude rétrospective multicentrique nationale
- Author
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Moret, L., primary, Ganea, A., additional, Dao, M., additional, Subra, J.F., additional, Noble, J., additional, Jourde-Chiche, N., additional, Mariat, C., additional, Touré, F., additional, Halimi, J.M., additional, and Audard, V., additional
- Published
- 2019
- Full Text
- View/download PDF
246. La néphropathie au lysozyme, une complication rare des leucémies myélomonocytaires chroniques
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Mohamadou, I., primary, Rabant, M., additional, Garcia, H., additional, Dao, M., additional, Gaudry, S., additional, Goujon, J.M., additional, Duong, J.P., additional, Brocheriou, I., additional, Buob, D., additional, and Rafat, C., additional
- Published
- 2019
- Full Text
- View/download PDF
247. Devenir à l’âge adulte des patients suivis pour un syndrome néphrotique idiopathique à début pédiatrique
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Dao, M., primary, Hummel, A., additional, Boyer, O., additional, Charbit, M., additional, Joly, D., additional, Dessaix, K., additional, Salomon, R., additional, Knebelmann, B., additional, and Servais, A., additional
- Published
- 2019
- Full Text
- View/download PDF
248. L’effet différentiel du récepteur cannabinoïde de type 1 dans différents modèles expérimentaux de néphropathie
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Dao, M., primary, Ferreira, M., additional, Colin, J., additional, Placier, S., additional, Vandermeersch, S., additional, Louedec, L., additional, Chatziantoniou, C., additional, and François, H., additional
- Published
- 2019
- Full Text
- View/download PDF
249. In utero and postnatal VX-770 administration rescues multiorgan disease in a ferret model of cystic fibrosis
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Sun, Xingshen, primary, Yi, Yaling, additional, Yan, Ziying, additional, Rosen, Bradley H., additional, Liang, Bo, additional, Winter, Michael C., additional, Evans, T. Idil Apak, additional, Rotti, Pavana G., additional, Yang, Yu, additional, Gray, Jaimie S., additional, Park, Soo Yeun, additional, Zhou, Weihong, additional, Zhang, Yulong, additional, Moll, Shashanna R., additional, Woody, Lisa, additional, Tran, Dao M., additional, Jiang, Licong, additional, Vonk, Annelotte M., additional, Beekman, Jeffrey M., additional, Negulescu, Paul, additional, Van Goor, Fred, additional, Fiorino, Dennis F., additional, Gibson-Corley, Katherine N., additional, and Engelhardt, John F., additional
- Published
- 2019
- Full Text
- View/download PDF
250. Rare metastatic patterns after malignant transformation of serous borderline tumor of the ovary
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Siemon, John, primary, Nguyen, Dao M, additional, Pinto, Andre, additional, and Schlumbrecht, Matthew, additional
- Published
- 2019
- Full Text
- View/download PDF
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