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205. The use of in vitro systems for evaluating immunotoxicity

Author

Gennari, A., Ban, M., Braun, A., Casati, S., Corsini, E., Dastych, J., Descotes, J., Hartung, T., Hooghe-Peters, R., House, R., Pallardy, M., Pieters, R., Reid, L., Tryphonas, H., Tschirhart, E., Tuschl, H., Vandebriel, R., Gribaldo, L., and Publica

Subjects
In vitro, Immunosuppression
Abstract

This is the report of a workshop organised by the European Centre for the Validation of Alternative Methods (ECVAM). ECVAM's main goal, as defined in 1993 by its Scientific Advisory Committee, is to promote the scientific and regulatory acceptance of alternative methods that are of importance to the biosciences and which replace, reduce or refine the use of laboratory animals. One of the first priorities set by ECVAM was the implementation of procedures that would enable it to become well informed about the state-of-the-art of non-animal test development and validation, and the potential for the possible incorporation of alternative tests into regulatory procedures. It was decided that this would be best achieved by the organization of ECVAM workshops on specific topics, at which small groups of invited experts would review the current status of various types of in vitro tests and their potential uses, and make recommendations about the best ways forward (Anonymous, 1994). The workshop on "The use of in vitro systems for evaluating Immunotoxicity" was held at ECVAM (Ispra), Italy, on 24th-26th November 2003. The participants represented academia, national organizations, international regulatory bodies and industry. The aim of the workshop was to review the state-of-the-art in the field of in vitro immunotoxicology, and to develop strategies towards the replacement of in vivo testing. At the end of this report are listed the recommendations that should be considered for prevalidation and validation of relevant and reliable procedures, that could replace the use of animals in chemical and cosmetics toxicity testing.

Published
2005

210. Traumatismes fermés parenchymateux de grade V : néphrectomie différée après contrôle de l’hémostase par embolisation

Author

Peilleron, N., primary, Long, J., additional, Fiard, G., additional, Carnicelli, D., additional, Rambeaud, J., additional, Terrier, N., additional, Iriart, C., additional, Lanchon, C., additional, Boillot, B., additional, Thuillier, C., additional, Arnoux, V., additional, Overs, C., additional, Poncet, D., additional, and Descotes, J., additional

Published
2014
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215. Open prostatectomy versus 180-W XPS GreenLight laser vaporization: Long-term functional outcome for prostatic adenomas>80 g

Author

Lanchon, C., Fiard, G., Long, J.-A., Arnoux, V., Carnicelli, D., Franquet, Q., Poncet, D., Bey, E., Lefrancq, J.-B., Grisard, S., Peilleron, N., Terrier, N., Boillot, B., Rambeaud, J.-J., Descotes, J.-L., and Thuillier, C.

Abstract

GreenLight photoselective vaporisation of the prostate (PVP) offers an endoscopic alternative to open prostatectomy (OP) for treatment of large adenomas. This study compares long-term functional outcome of both techniques in patients with Benign prostatic obstruction (BPO)>80g.

Published
2018
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216. [Physiopathology of eczema]

Author

Krasteva M, Choquet G, Descotes J, and JEAN FRANCOIS NICOLAS

Subjects
Inflammation, Langerhans Cells, T-Lymphocytes, Eczema, Antigen-Presenting Cells, Humans, Hypersensitivity, Delayed, Dermatitis, Contact, Lymphocyte Activation, Dermatitis, Atopic
Abstract

Eczema is a skin inflammatory reaction mediated by antigen-specific T cells. Two main disorders belong to this group: contact dermatitis and atopic dermatitis. The pathophysiological mecanisms involved in both disorders are similar and include, at the cellular level, three elements: the antigen (hapten or environmental antigen), antigen-presenting cells belonging to the group of dendritic cells and antigen-specific T cells. The Langerhans cell responsible for antigen handling and presentation to specific T cells appears to play a central role for the generation of the inflammatory reaction.

Published
2002

217. Approaches to risk assessment of immunotoxic effects of chemicals

Author

Richter-Reichhelm, H.-B., Stahlmann, R., Smith, E., Loveren, H. van, Althoff, J., Bass, R., Corsini, E., Dayan, A., Dean, J.H., Descotes, J., Emmendörffer, A., Eppler, R., Hall, A.J., Herrman, J.L., Lovik, M., Luster, M.I., Miller, F.W., Riecke, K., Schöning, G., Schulte, A., Smialowicz, R.J., Ulrich, P., Vohr, H.-W., Vos, J.G., White, K.L. jr., and Publica

Published
2001

231. Performance de la biopsie endoscopique d’une tumeur de la voie excrétrice supérieure pour la détermination du stade et du grade

Author

Arvin-berod, A., primary, Fiard, G., additional, Pasquier, D., additional, Decaussin-Petrucci, M., additional, Arnouil, N., additional, Thuillier, C., additional, Boillot, B., additional, Terrier, N., additional, Descotes, J.-L., additional, Paparel, P., additional, Rambeaud, J.-J., additional, Ruffion, A., additional, and Long, J.-A., additional

Published
2012
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235. Traumatismes fermés du rein avec extravasation urinaire : résultats à long terme d’une attitude conservatrice

Author

Long, J.-A., primary, Fiard, G., additional, Skowron, O., additional, Descotes, J.-L., additional, Boillot, B., additional, Terrier, N., additional, Thuillier, C., additional, Arvin-berod, A., additional, Arnoux, V., additional, Chodez, M., additional, Lanchon, C., additional, Iriart, C., additional, and Rambeaud, J.-J., additional

Published
2012
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241. Prise en charge des pseudo-anévrismes rénaux intraparenchymateux post-traumatiques : à propos d’une série de 325 patients traumatisés rénaux

Author

Guyot, R., Arnoux, V., Descotes, J.-L., Terrier, N., Boillot, B., Thuillier, C., Rambeaud, J.-J., Long, J.-A., and Fiard, G.

Abstract

L’objectif a été de décrire la prise en charge des pseudo-anévrismes (PA) post-traumatiques, intraparenchymateux, dans notre centre ; de la comparer aux données de la littérature afin de proposer un algorithme de prise en charge.

Published
2017
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242. Prostatectomie radicale laparoscopique robot-assistée : quelles sont les preuves à l’heure d’une demande de nomenclature spécifique ?

Author

Long, J.-A., Poinas, G., Fiard, G., Leprêtre, M., Delaitre-Bonnin, C., Rébillard, X., and Descotes, J.-L.

Abstract

Malgré une diminution du nombre de prostatectomies totales en France, la proportion de prostatectomies assistées par robot augmente. L’objectif de ce travail est de faire une mise au point comparant les résultats de la prostatectomie robot-assistée avec ceux des voies d’abord ouverte et cœlioscopique.

Published
2017
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