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203. Determinants of Covid19 disease and of survival after Covid19 in MPN patients treated with ruxolitinib

Author

Palandri, Francesca, Elli, Elena M., Auteri, Giuseppe, Bonifacio, Massimiliano, Benevolo, Giulia, Heidel, Florian H., Paglia, Simona, Trawinska, Malgorzata M., Bosi, Costanza, Rossi, Elena, Tiribelli, Mario, Tieghi, Alessia, Iurlo, Alessandra, Polverelli, Nicola, Caocci, Giovanni, Binotto, Gianni, Cavazzini, Francesco, Beggiato, Eloise, Cilloni, Daniela, Tatarelli, Caterina, Mendicino, Francesco, Miglino, Maurizio, Bocchia, Monica, Crugnola, Monica, Mazzoni, Camilla, Romagnoli, Andrea D., Rindone, Giovanni, Ceglie, Sara, D’Addio, Alessandra, Santoni, Eleonora, Cattaneo, Daniele, Bartoletti, Daniela, Lemoli, Roberto M., Krampera, Mauro, Cuneo, Antonio, Semenzato, Gianpietro C., Latagliata, Roberto, Abruzzese, Elisabetta, Vianelli, Nicola, Cavo, Michele, Andriani, Alessandro, De Stefano, Valerio, Palumbo, Giuseppe A., and Breccia, Massimo

Published
2023
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204. A miRNA screening identifies miR-192-5p as associated with response to azacitidine and lenalidomide therapy in myelodysplastic syndromes

Author

Mongiorgi, Sara, De Stefano, Alessia, Ratti, Stefano, Indio, Valentina, Astolfi, Annalisa, Casalin, Irene, Pellagatti, Andrea, Paolini, Stefania, Parisi, Sarah, Cavo, Michele, Pession, Andrea, McCubrey, James A., Suh, Pann-Ghill, Manzoli, Lucia, Boultwood, Jacqueline, Finelli, Carlo, Cocco, Lucio, and Follo, Matilde Y.

Published
2023
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212. The Motion Suspension System – MSS: A Cable-Driven System for On-Ground Tests of Space Robots

Author

Elhardt, Ferdinand, Boumann, Roland, De Stefano, Marco, Heidel, Robin, Lemmen, Patrik, Heumos, Martin, Jeziorek, Christoph, Roa, Maximo A., Schedl, Manfred, Bruckmann, Tobias, Ceccarelli, Marco, Series Editor, Agrawal, Sunil K., Advisory Editor, Corves, Burkhard, Advisory Editor, Glazunov, Victor, Advisory Editor, Hernández, Alfonso, Advisory Editor, Huang, Tian, Advisory Editor, Jauregui Correa, Juan Carlos, Advisory Editor, Takeda, Yukio, Advisory Editor, and Okada, Masafumi, editor

Published
2023
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213. Peritoneal Carcinomatosis

Author

Francesca, De Stefano, Fugazzola, Paola, Lorenzo, Cobianchi, Tommaso, Dominioni, Matteo, Tomasoni, Jacopo, Viganò, Luca, Ansaloni, Coccolini, Federico, Series Editor, Coimbra, Raul, Series Editor, Kirkpatrick, Andrew W., Series Editor, Di Saverio, Salomone, Series Editor, Ansaloni, Luca, Editorial Board Member, Balogh, Zsolt, Editorial Board Member, Biffl, Walt, Editorial Board Member, Catena, Fausto, Editorial Board Member, Davis, Kimberly, Editorial Board Member, Ferrada, Paula, Editorial Board Member, Fraga, Gustavo, Editorial Board Member, Ivatury, Rao, Editorial Board Member, Kluger, Yoram, Editorial Board Member, Leppaniemi, Ari, Editorial Board Member, Maier, Ron, Editorial Board Member, Moore, Ernest E., Editorial Board Member, Napolitano, Lena, Editorial Board Member, Peitzman, Andrew, Editorial Board Member, Reilly, Patrick, Editorial Board Member, Rizoli, Sandro, Editorial Board Member, Sakakushev, Boris E., Editorial Board Member, Sartelli, Massimo, Editorial Board Member, Scalea, Thomas, Editorial Board Member, Spain, David, Editorial Board Member, Stahel, Philip, Editorial Board Member, Sugrue, Michael, Editorial Board Member, Velmahos, George, Editorial Board Member, Weber, Dieter, Editorial Board Member, Tarasconi, Antonio, editor, Bui, Simona, editor, Chirica, Mircea, editor, Roth, Gaël, editor, and Nahmias, Jeffry, editor

Published
2023
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214. Predicting Alzheimer’s Disease: A Stroke-Based Handwriting Analysis Approach Based on Machine Learning

Author

Cilia, Nicole Dalia, D’Alessandro, Tiziana, De Stefano, Claudio, Fontanella, Francesco, Nardone, Emanuele, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Rousseau, Jean-Jacques, editor, and Kapralos, Bill, editor

Published
2023
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215. Application of Cluster Analysis to Electricity Generation Data from the Santo Antônio Hydroelectric Plant in the State of Rondônia, Brazil

Author

Ribeiro, João Gabriel, dos Santos Dias, Carlos Tadeu, de Stefano Piedade, Sônia Maria, Vale, Giovane Maia do, de Jesus Silva Oliveira, Vlademir, Howlett, Robert J., Series Editor, Jain, Lakhmi C., Series Editor, Iano, Yuzo, editor, Saotome, Osamu, editor, Kemper Vásquez, Guillermo Leopoldo, editor, de Moraes Gomes Rosa, Maria Thereza, editor, Arthur, Rangel, editor, and Gomes de Oliveira, Gabriel, editor

Published
2023
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216. Multi-Hazard and Multi-vulnerability Analysis in Historical Urban Areas: Challenges and Opportunities

Author

Arrighi, Chiara, Tanganelli, Marco, Cardinali, Vieri, Cristofaro, Maria Teresa, Marra, Antonino Maria, Castelli, Fabio, De Stefano, Mario, Pisello, Anna Laura, Editorial Board Member, Hawkes, Dean, Editorial Board Member, Bougdah, Hocine, Editorial Board Member, Rosso, Federica, Editorial Board Member, Abdalla, Hassan, Editorial Board Member, Boemi, Sofia-Natalia, Editorial Board Member, Mohareb, Nabil, Editorial Board Member, Mesbah Elkaffas, Saleh, Editorial Board Member, Bozonnet, Emmanuel, Editorial Board Member, Pignatta, Gloria, Editorial Board Member, Mahgoub, Yasser, Editorial Board Member, De Bonis, Luciano, Editorial Board Member, Kostopoulou, Stella, Editorial Board Member, Pradhan, Biswajeet, Editorial Board Member, Abdul Mannan, Md., Editorial Board Member, Alalouch, Chaham, Editorial Board Member, O. Gawad, Iman, Editorial Board Member, Nayyar, Anand, Editorial Board Member, Amer, Mourad, Series Editor, Malheiro, Ana, editor, Fernandes, Francisco, editor, and Chaminé, Helder I., editor

Published
2023
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218. Parameterized Surrogate Models of Microstrip Structures for Electromagnetic-Based Power Amplifier Design and Statistical Analysis

Author

Ramella, Chiara, Zanco, Alessandro, De Stefano, Marco, Bradde, Tommaso, Grivet-Talocia, Stefano, Pirola, Marco, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Cocorullo, Giuseppe, editor, Crupi, Felice, editor, and Limiti, Ernesto, editor

Published
2023
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221. Laparoscopic versus open resection for hepatocellular carcinoma according to the procedure’s complexity: real-world weighted data from a national register

Author

Corleone, PioS., Ciulli, Cristina, Bernasconi, Davide, Donadon, Matteo, Procopio, Fabio, Razionale, Francesco, Ratti, Francesca, Romano, Pierluigi, De Carlis, Riccardo, Russolillo, Nadia, Marinelli, Laura, Iaria, Maurizio, De Stefano, Francesca, Scarinci, Andrea, Laureiro, Zoe L., Scotti, Mauro, Marchitelli, Ivan, Rompianesi, Gianluca, Cucchetti, Alessandro, Franceschi, Angelo, Casella, Annachiara, Cosola, Davide, Patrizia, Pelizzo, Notte, Francesca, Patrone, Renato, Manzoni, Alberto, Sciannamea, Ivano, Malagnino, Alessia, Cammarata, Francesco, Mantovani, Guido, Famularo, Simone, Milana, Flavio, Ardito, Francesco, Cipriani, Federica, Vitale, Alessandro, Lauterio, Andrea, Serenari, Matteo, Fontana, Andrea, Nicolini, Daniele, Giuffrida, Mario, Garancini, Mattia, Dominioni, Tommaso, Zanello, Matteo, Perri, Pasquale, Lai, Quirino, Conci, Simone, Molfino, Sarah, Giglio, Mariano, LaBarba, Giuliano, Ferrari, Cecilia, Conticchio, Maria, Germani, Paola, Romano, Maurizio, Patauner, Stefan, Belli, Andrea, Zimmitti, Giuseppe, Antonucci, Adelmo, Fumagalli, Luca, Troci, Albert, De Angelis, Michela, Boccia, Luigi, Crespi, Michele, Hilal, Moh’d A., Izzo, Francesco, Frena, Antonio, Zanus, Giacomo, Tarchi, Paola, Memeo, Riccardo, Griseri, Guido, Ercolani, Giorgio, Troisi, Roberto, Baiocchi, Gian L., Ruzzenente, Andrea, Rossi, Massimo, Grazi, Gian L., Jovine, Elio, Maestri, Marcello, Romano, Fabrizio, Valle, Raffaele D., Vivarelli, Marco, Ferrero, Alessandro, Cescon, Matteo, De Carlis, Luciano, Cillo, Umberto, Aldrighetti, Luca, Giuliante, Felice, and Torzilli, Guido

Published
2024
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226. Suction in Percutaneous Nephrolithotripsy: Evolution, Development, and Outcomes from Experimental and Clinical studies. Results from a Systematic Review

Author

De Stefano, Virgilio, Castellani, Daniele, Somani, Bhaskar K., Giulioni, Carlo, Cormio, Angelo, Galosi, Andrea Benedetto, Sarica, Kemal, Glover, Xavier, da Silva, Rodrigo Donalisio, Tanidir, Yiloren, Gadzhiev, Nariman, Pirola, Giacomo Maria, Mulawkar, Prashant Motiram, Teoh, Jeremy Yuen-Chun, Monga, Manoj, Herrmann, Thomas R.W., and Gauhar, Vineet

Published
2024
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227. Deciphering signaling pathways in hematopoietic stem cells: the molecular complexity of Myelodysplastic Syndromes (MDS) and leukemic progression

Author

Casalin, Irene, De Stefano, Alessia, Ceneri, Eleonora, Cappellini, Alessandra, Finelli, Carlo, Curti, Antonio, Paolini, Stefania, Parisi, Sarah, Zannoni, Letizia, Boultwood, Jacqueline, McCubrey, James A., Suh, Pann-Ghill, Ramazzotti, Giulia, Fiume, Roberta, Ratti, Stefano, Manzoli, Lucia, Cocco, Lucio, and Follo, Matilde Y.

Published
2024
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238. The access route through the anatomical snuffbox in ultrasound-guided synovial biopsy of the wrist allows for a safe and effective collection of tissue samples in inflammatory arthritis

Author

Ludovico De Stefano, Serena Bugatti, Veronica Piccin, Gioacchino D’Ambrosio, Terenzj Luvaro, Blerina Xoxi, Carlomaurizio Montecucco, and Antonio Manzo

Subjects
Synovial biopsy, Synovitis, Ultrasound, Wrist, Small joints, Arthritis, Diseases of the musculoskeletal system, RC925-935
Abstract

Abstract Background A proof-of-concept study to evaluate the feasibility and safety of minimally invasive ultrasound (US)-guided synovial biopsy of the radiocarpal (RC) joint using the anatomical snuffbox as an access route. Methods Twenty consecutive patients with active chronic arthritis of the wrist underwent minimally invasive US-guided synovial biopsy of the RC joint using the anatomical snuffbox as the access route. Samples were retrieved from 3 predetermined biopsy target sites of the RC synovia (proximal, vault, and distal site), aiming for a minimum of 12 samples. The procedure’s feasibility was evaluated based on the number and histological quality of retrieved tissue fragments tested on pre-defined histometric parameters. The safety and tolerability of the procedure were assessed through 1-week and 1-month follow-up clinical evaluations. Results A median number of 17 fragments (≥ 1 mm diameter size at macroscopic evaluation) per procedure was processed for histopathology (range 9–24) and dedicated to the study. At the histopathologic evaluation, a gradable tissue (visible lining layer and ≥ 4 fragments with IST) was recognized in 19/20 biopsies (95%), and all pre-defined histometric parameters were judged applicable and successfully measured in 19/19 gradable biopsies. All three biopsy target sites showed sampling accessibility. The entire procedure was generally well tolerated. At the 1-month follow-up, no patients showed infectious complications. Conclusions The access route through the anatomical snuff box in US-guided synovial biopsies of the RC joint allows for a safe and targeted collection of adequate tissue samples. This modification of the traditional access route may allow easier, repeatable, and safer sampling of anatomically distinct areas of the wrist in the course of arthritis.

Published
2023
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239. Improving Outcomes of Same-sitting Bilateral Flexible Ureteroscopy for Renal Stones in Real-world Practice—Lessons Learnt from Global Multicenter Experience of 1250 Patients

Author

Daniele Castellani, Olivier Traxer, Deepak Ragoori, Andrea Benedetto Galosi, Virgilio De Stefano, Nariman Gadzhiev, Yiloren Tanidir, Takaaki Inoue, Esteban Emiliani, Saeed Bin Hamri, Mohamed Amine Lakmichi, Chandra Mohan Vaddi, Chin Tiong Heng, Boyke Soebhali, Sumit More, Vikram Sridharan, Mehmet Ilker Gökce, Azimdjon N. Tursunkulov, Arvind Ganpule, Giacomo Maria Pirola, Angelo Naselli, Cemil Aydin, Fernando Ramón de Fata Chillón, Catalina Solano Mendoza, Luigi Candela, Ben Hall Chew, Bhaskar Kumar Somani, and Vineet Gauhar

Subjects
Kidney calculi, Flexible ureteroscopy, Lithotripsy, Laser, Retrograde intrarenal surgery, Holmium laser, Diseases of the genitourinary system. Urology, RC870-923, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Background: Bilateral kidney stones are commonly treated in staged procedures. Objective: To evaluate outcomes after same-sitting bilateral retrograde intrarenal surgery (SSB-RIRS) for renal stones. Design, setting, and participants: Data from adults who underwent bilateral RIRS in 21 centers were retrospectively reviewed (from January 2015 to June 2022). The inclusion criteria were unilateral/bilateral symptomatic bilateral stone(s) of any size/location in both kidneys and bilateral stones on follow-up with symptom/stone progression. Stone-free rate (SFR) was defined as absence of any fragment >3 mm at 3 mo. Outcome measurements and statistical analysis: Continuous variables are presented as medians and 25–75th percentiles. A multivariable logistic regression analysis was performed to evaluate independent predictors of sepsis and bilateral SFR. Results and limitations: A total of 1250 patients were included. The median age was 48.0 (36–61) yr. Of the patients, 58.2% were prestented. The median stone diameter was 10 mm on both sides. Multiple stones were present in 45.3% and 47.9% of the left and right kidneys, respectively. Surgery was stopped in 6.8% of cases. The median surgical time was 75.0 (55–90) min. Complications were transient fever (10.7%), fever/infection needing prolonged stay (5.5%), sepsis (2%), and blood transfusion (1.3%). Bilateral and unilateral SFRs were 73.0% and 17.4%, respectively. Female (odds ratio [OR] 2.97, 95% confidence interval [CI] 1.18–7.49, p = 0.02), no antibiotic prophylaxis (OR 5.99, 95% CI 2.28–15.73, p

Published
2023
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240. Unexpected epileptogenic effect of lethal doses of pentobarbital: a case report

Author

Amélie Giudicelli-Bailly, Chiara Della Badia, Marc Augsburger, Hervé Quintard, Raphaël Giraud, and Pia De Stefano

Subjects
pentobarbital, status epilepticus, nonconvulsive status epilepticus, ictal–interictal continuum, forensic science, Neurology. Diseases of the nervous system, RC346-429
Abstract

Background Barbiturate poisoning is rare but potentially fatal. Case Report We reported a case of barbiturate poisoning in a 28-year-old woman who recovered from lethal pentobarbital deliberate self-poisoning. The initial blood pentobarbital concentration was 61 mg/L, corresponding to a potentially lethal dose. Despite the ingestion of a high dose of pentobarbital, the electroencephalogram revealed an unattended pattern compatible with possible nonconvulsive status epilepticus. Following resuscitation maneuvers, appropriate care, and antiseizure medication, the patient awakened after 7 days. The evolution was excellent without neurological deficits at 2 months. Conclusion Despite the expected and known effects of high-dose pentobarbital in reducing and suppressing cortical activity in the brain, the present case demonstrates that lethal dose of pentobarbital may have an epileptogenic effect. Our hypothesis was that the mechanism of the origin of such a picture is a relatively abrupt decrease in toxic doses of pentobarbital, resulting in a withdrawal phenomenon.

Published
2023
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241. Diagnostic role of minor salivary glands biopsy in Sjögren’s syndrome: correlations between histology and autoimmunity in a large, monocentric cohort

Author

Edoardo Conticini, Marco Bardelli, Antonio Vitale, Renato De Stefano, Paolo Falsetti, Enrico Selvi, Maria Romana Bacarelli, Roberto D’Alessandro, Luca Cantarini, Bruno Frediani, and Stefano Gentileschi

Subjects
sjögren’s syndrome, histology, autoimmunity, biopsy, minor salivary glands, Medicine
Abstract

Introduction Based on ACR/EULAR classification criteria, minor salivary glands biopsy (MSGB) is a useful diagnostic tool for the diagnosis of primary Sjögren’s syndrome (SS). The main objective of our study was to evaluate the diagnostic role of MSGB, as well as to highlight correlations between histological findings and autoimmune profiles. Material and methods We retrospectively evaluated histological and autoimmunity data from patients who underwent MSGB in our department in cases of suspected SS, from March 2011 to December 2018. Salivary gland samples were evaluated using Chisholm and Mason (CM) grading and the focus score (FS). Results A total of 1,264 patients (108 males, 1,156 females) were included. The median age was 55.22 ±13.51 years (range: 15–87). In univariate binary logistic regression, CM ≥ 3 and FS ≥ 1 were significantly predicted by antinuclear antibodies (ANA), anti-extractable nuclear antigens (ENA) and anti-Ro/SSA titer as well as anti-La/SSB, anti-Ro/SSA, rheumatoid factor (RF) and anti-citrullinated protein antibodies (ACPA) positivity. In multivariate analysis, CM ≥ 3 and MSGB positivity were significantly associated with ANA titer; FS ≥ 1 was not associated with laboratory findings. A positive biopsy was associated with laboratory findings, as ANA and ENA titers, anti-Ro/SSA, anti-La/SSB, RF and ACPA positivity may discriminate patients with SS-related histological findings. Conclusions Minor salivary glands biopsy is a useful tool to diagnose SS in cases of highly suggestive clinical symptoms but in the absence of a specific autoimmunity.

Published
2023
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244. Expert consensus on the treatment of patients with adult-onset still's disease with the goal of achieving an early and long-term remission

Author

Belfiore, Norma, Bernardi, Cristina, Gabini, Marco, Bettio, Silvano, Brucato, Antonio, Italiano, Giovanni, Cantatore, Francesco Paolo, Iacono, Daniela, Pantano, Ilenia, Tirri, Enrico, Ursini, Francesco, Monaco, Andrea Lo, Caso, Francesco, Quartuccio, Luca, Chimenti, Maria Sole, Gattamelata, Angelica, Gremese, Elisa, Paroli, Marino, Picchianti-Diamanti, Andrea, Sebastiani, Gian Domenico, Favalli, Ennio, Sulli, Alberto, Frassi, Micol, Faggioli, Paola, Foti, Rosario, Campochiaro, Corrado, Cavalli, Giulio, Tomelleri, Alessandro, Manara, Maria, De Stefano, Ludovico, De Angelis, Rossella, Parisi, Simone, Lopalco, Giuseppe, Piga, Matteo, Marotto, Daniela, Colaci, Michele, Padula, Angela, Guggino, Giuliana, Emmi, Giacomo, Baldini, Chiara, Sota, Jurgen, Vitale, Antonio, Berti, Alvise, Bartoloni, Elena, Grava, Chiara, Bindoli, Sara, Vitetta, Rosetta, Giacomelli, Roberto, Caporali, Roberto, Ciccia, Francesco, Colafrancesco, Serena, Dagna, Lorenzo, Govoni, Marcello, Iannone, Florenzo, Leccese, Pietro, Montecucco, Carlomaurizio, Pappagallo, Giovanni, Pistone, Giovanni, Priori, Roberta, Ruscitti, Piero, Sfriso, Paolo, and Cantarini, Luca

Published
2023
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