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Prior research suggests the significance of religion for development and wellbeing in adolescence and beyond. Further, new developments and applications of statistical methods have led to ways of better accounting for the multidimensional nature of religiosity (e.g. latent class analysis), as well as the dynamic aspects of religiosity (e.g. latent growth curve models). Yet, rarely if ever are both features of religiosity incorporated and examined together. Therefore, we propose and conduct a latent class analysis using data from the National Longitudinal Study of Adolescent to Adult Health (Add Health) to identify seven distinct pathways of religiosity that involve independently changing levels of religious affiliation, religious service attendance, personal importance of religion, and prayer from adolescence to adulthood. We also show how individuals' religious pathways are related to gender, race, parents' education, their own education, and family formation experiences in the transition to adulthood. Our findings inform the study of how multiple dimensions of religiosity take shape across adolescence and the transition to adulthood, and suggest a new way for measuring the dynamics of religiosity in studies of the impact of religion across the life course.

College selectivity is associated with numerous positive life outcomes, but research on the antecedents of college selectivity, including religion, is limited—despite a long tradition of religion and stratification research. Using survey data from the National Longitudinal Study of Adolescent to Adult Health (N=2,093) and semi-structured interviews from the National Study of Youth and Religion (N=46), we test for and seek to explain differences in the college selectivity of students from conservative Protestant (CP) religious backgrounds compared to others. Based on prior literature and theory, we hypothesize that CPs attend less selective colleges than other young adults, and that this may especially be the case among women. Our quantitative findings suggest CPs do attend less selective colleges, and the difference is greater among those with better high school GPAs. These differences vary by gender: They are nonexistent for men once background factors are controlled, but CP women attend less selective colleges—a difference that is even larger among women with higher academic ability. Our qualitative findings suggest that these differences stem from young women’s different understandings of the purposes of college (general self-betterment versus human capital investment) which relate to unique strategies for balancing work and family, enacting altruism, and achieving self-satisfaction. These findings show the continued link between religion and stratification and, more broadly, culture and stratification.

This study integrates theory and research on household fission (or partition) and migration to better understand living arrangements following marriage, especially in historically patrilocal and primarily agricultural settings. Using panel data from the Chitwan Valley Family Study to analyze the sequential decision-making process that influences men’s living arrangements subsequent to first marriage, we demonstrate the importance of distinguishing among extended family living, temporary migration, and the establishment of an independent household. We find that community economic characteristics, such as access to markets or employment, as well as household wealth affect the initial decision to leave the natal home. Household resources and use of farmland, along with the young men’s own education, media exposure, travel, and marital behavior, influence the decision to make the departure from the natal home permanent. Our findings explain why previous results regarding household fission and those focused on migration have provided such mixed results, and we establish a new framework for thinking about how families and individuals manage living situations.

Background Adverse birth and neonatal outcomes disproportionately affect African American women and infants compared to those of other races/ethnicities. While significant research has sought to identify underlying factors contributing to these disparities, current understanding remains limited, constraining prevention, early diagnosis, and treatment. With the development of next generation sequencing techniques, the contribution of the vaginal microbiome to adverse maternal and neonatal outcomes has come under consideration. However, most microbiome in pregnancy studies include few African American women, do not consider the potential contribution of non-vaginal microbiome sites, and do not consider the effects of sociodemographic or behavioral factors on the microbiome. Methods We conceived our on-going, 5-year longitudinal study, Biobehavioral Determinants of the Microbiome and Preterm Birth in Black Women, as an intra-race study to enable the investigation of risk and protective factors within the disparate group. We aim to recruit over 500 pregnant African American women, enrolling them into the study at 8–14 weeks of pregnancy. Participants will be asked to complete questionnaires and provide oral, vaginal, and gut microbiome samples at enrollment and again at 24–30 weeks. Chart review will be used to identify pregnancy outcomes, infections, treatments, and complications. DNA will be extracted from the microbiome samples and sequencing of the V3 and V4 regions of the 16S rRNA gene will be conducted. Processing and mapping will be completed with QIIME and operational taxonomic units (OTUs) will be mapped to Greengenes version 13_8. Community state types (CSTs) and diversity measures at each site and time will be identified and considered in light of demographic, psychosocial, clinical, and biobehavioral variables. Discussion This rich data set will allow future consideration of risk and protective factors, between and within groups of women, providing the opportunity to uncover the roots of the persistent health disparity experienced by African American families.

Rationale: Leukocyte telomere length (LTL) is a biological marker of aging, and shorter LTL is associated with adverse cardiovascular outcomes. Reduced regenerative capacity has been proposed as a mechanism. Bone marrow–derived circulating progenitor cells are involved in tissue repair and regeneration. Objective: Main objective of this study was to examine the relationship between LTL and progenitor cells and their impact on adverse cardiovascular outcomes. Methods and Results: We measured LTL by quantitative polymerase chain reaction in 566 outpatients (age: 63±9 years; 76% men) with coronary artery disease. Circulating progenitor cells were enumerated by flow cytometry. After adjustment for age, sex, race, body mass index, smoking status, and previous myocardial infarction, a shorter LTL was associated with a lower CD34 + cell count: for each 10% shorter LTL, CD34 + levels were 5.2% lower ( P Conclusions: Although shorter LTL is associated with decreased regenerative capacity, both LTL and circulating progenitor cell levels are independent and additive predictors of adverse cardiovascular outcomes in coronary artery disease patients. Our results suggest that both biological aging and reduced regenerative capacity contribute to cardiovascular events, independent of conventional risk factors.

Toxoplasma gondii (TOXO) is a neuroinvasive protozoan parasite that induces the formation of persistent cysts in mammalian brains. It infects approximately 1.1 million people in the United States annually. Latent TOXO infection is implicated in the etiology of psychiatric disorders, especially schizophrenia (Scz), and has been correlated with modestly impaired cognition. The acoustic startle response (ASR) is a reflex seen in all mammals. It is mediated by a simple subcortical circuit, and provides an indicator of neural function. We previously reported the association of TOXO with slowed acoustic startle latency, an index of neural processing speed, in a sample of schizophrenia and healthy control subjects. The alterations in neurobiology with TOXO latent infection may not be specific to schizophrenia. Therefore we examined TOXO in relation to acoustic startle in an urban, predominately African American, population with mixed psychiatric diagnoses, and healthy controls. Physiological and diagnostic data along with blood samples were collected from 364 outpatients treated at an inner-city hospital. TOXO status was determined with an ELISA assay for TOXO-specific IgG. A discrete titer was calculated based on standard cut-points as an indicator of seropositivity, and the TOXO-specific IgG concentration served as serointensity. A series of linear regression models were used to assess the association of TOXO seropositivity and serointensity with ASR magnitude and latency in models adjusting for demographics and psychiatric diagnoses (PTSD, major depression, schizophrenia, psychosis, substance abuse). ASR magnitude was 11.5% higher in TOXO seropositive subjects compared to seronegative individuals (p=0.01). This effect was more pronounced in models with TOXO serointensity that adjusted for sociodemographic covariates (F=7.41, p=.0068; F=10.05, p=0.0017), and remained significant when psychiatric diagnoses were stepped into the models. TOXO showed no association with startle latency (t=0.49, p=0.63) in an unadjusted model, nor was TOXO associated with latency in models that included demographic factors. After stepping in individual psychiatric disorders, we found a significant association of latency with a diagnosis of PTSD (F=5.15, p=0.024), but no other psychiatric diagnoses, such that subjects with PTSD had longer startle latency. The mechanism by which TOXO infection is associated with high startle magnitude is not known, but possible mechanisms include TOXO cyst burden in the brain, parasite recrudescence, or molecular mimicry of a host epitope by TOXO. Future studies will focus on the neurobiology underlying the effects of latent TOXO infection as a potential inroad to the development of novel treatment targets for psychiatric disease.

When a disaster strikes, the well-being of Emergency Operations Centre (EOC) personnel is often not the first priority for emergency managers working to help provide support to their local community and the incident command site. Through the development and testing of an iterative series of simulation exercises with EOC personnel, this study identified adverse psychosocial outcomes that may emerge within an EOC during an emergency. Having identified a number of practices which led to less than desired psychosocial outcomes, researchers developed a training and awareness video to identify the practices and demonstrate strategies to overcome negative impacts. A comparative analysis was undertaken to compare EOC actions pre- and post-exposure to the video. The results indicated a change in behaviour following the viewing of the video and supported training initiatives that stress the importance of strong leadership in an EOC, encouraging staff to take breaks, respecting diversity, and providing psychosocial support.

Background The response of progenitor cells (PCs) to transient myocardial ischemia in patients with coronary artery disease remains unknown. We aimed to investigate the PC response to exercise‐induced myocardial ischemia (ExMI) and compare it to flow mismatch during pharmacological stress testing. Methods and Results A total of 356 patients with stable coronary artery disease underwent 99mTc‐sestamibi myocardial perfusion imaging during exercise (69%) or pharmacological stress (31%). CD 34 + and CD 34 + /chemokine (C‐X‐C motif) receptor 4 PC s were enumerated by flow cytometry. Change in PC count was compared between patients with and without myocardial ischemia using linear regression models. Vascular endothelial growth factor and stromal‐derived factor‐1α were quantified. Mean age was 63±9 years; 76% were men. The incidence of Ex MI was 31% and 41% during exercise and pharmacological stress testing, respectively. Patients with Ex MI had a significant decrease in CD 34 + /chemokine (C‐X‐C motif) receptor 4 (−18%, P =0.01) after stress that was inversely correlated with the magnitude of ischemia ( r =−0.19, P =0.003). In contrast, patients without Ex MI had an increase in CD 34 + /chemokine (C‐X‐C motif) receptor 4 (14.7%, P =0.02), and those undergoing pharmacological stress had no change. Plasma vascular endothelial growth factor levels increased (15%, P PC counts in those with Ex MI ( P =0.03), suggesting a greater decrease in PC s in those with a greater change in stromal‐derived factor‐1α level with exercise. Conclusions Ex MI is associated with a significant decrease in circulating levels of CD 34 + /chemokine (C‐X‐C motif) receptor 4 PC s, likely attributable, at least in part, to stromal‐derived factor‐1α–mediated homing of PC s to the ischemic myocardium. The physiologic consequences of this uptake of PC s and their therapeutic implications need further investigation.

In this article, we examine whether mother’s and father’s self-reported religiousness relates differently to the timing of their children’s marriages. Conceptualizing religion as one source of cultural schema about marriage that is likely to conflict with other schemas for living, and theorizing that women are more likely to experience structured ambivalence over religious schema and their enactment than men, we predict father’s religiousness will be associated with children’s marriage in accordance with religious dogma, whereas the experience of structured ambivalence yields a more complex relationship between mother’s religiousness and their children’s marriage. Using longitudinal data from the Chitwan Valley Family Study in Nepal, a primarily Hindu and Buddhist setting, we find contrasting associations between son’s marriage timing and mothers’ and fathers’ religiousness. This provides empirical support for theoretical frameworks that emphasize the gendered nature of religious identity and suggests the influence of religion on other aspects of life is gendered.

In 2006 Vega was discovered to display excess near-infrared emission. Surveys now detect this phenomenon for one fifth of main-sequence stars, across various spectral types and ages. The excesses are interpreted as populations of small, hot dust grains very close to their stars, which must originate from comets or asteroids. However, the presence of such grains in copious amounts is mysterious, since they should rapidly sublimate or be blown out of the system. Here we investigate a potential mechanism to generate excesses: dust migrating inwards under radiation forces sublimates near the star, releasing modest quantities of gas which then traps subsequent grains. This mechanism requires neither specialised system architectures nor high dust supply rates, and could operate across diverse stellar types and ages. The model naturally reproduces many features of inferred dust populations, in particular their location, preference for small grains, steep size distribution, and dust location scaling with stellar luminosity. For Sun-like stars the mechanism can produce 2.2 micron excesses that are an order of magnitude larger than those at 8.5 micron, as required by observations. However, for A-type stars the simulated near-infrared excesses were only twice those in the mid infrared; grains would have to be 5-10 times smaller than those trapped in our model to be able to explain observed near-infrared excesses around A stars. Further progress with any hot dust explanation for A stars requires a means for grains to become very hot without either rapidly sublimating or being blown out of the system., Comment: 19 pages, 9 figures. Accepted for publication in MNRAS

HD 38206 is an A0V star in the Columba association, hosting a debris disc first discovered by IRAS. Further observations by Spitzer and Herschel showed that the disc has two components, likely analogous to the asteroid and Kuiper belts of the Solar System. The young age of this star makes it a prime target for direct imaging planet searches. Possible planets in the system can be constrained using the debris disc. Here we present the first ALMA observations of the system's Kuiper belt and fit them using a forward modelling MCMC approach. We detect an extended disc of dust peaking at around 180 au with a width of 140 au. The disc is close to edge on and shows tentative signs of an asymmetry best fit by an eccentricity of $0.25^{+0.10}_{-0.09}$. We use the fitted parameters to determine limits on the masses of planets interior to the cold belt. We determine that a minimum of four planets are required, each with a minimum mass of 0.64 M$_J$, in order to clear the gap between the asteroid and Kuiper belts of the system. If we make the assumption that the outermost planet is responsible for the stirring of the disc, the location of its inner edge and the eccentricity of the disc, then we can more tightly predict its eccentricity, mass and semimajor axis to be $e_{\rm{p}}=0.34^{+0.20}_{-0.13}$, $m_{\rm{p}}=0.7^{+0.5}_{-0.3}\,\rm{M}_{\rm{J}}$ and $a_{\rm{p}}=76^{+12}_{-13}\,\rm{au}$., Comment: 9 pages, 5 figures, accepted for publication in MNRAS

This retrospective study investigates the adherence to local guidelines during the treatment of paediatric patients with pertussis and follows their clinical outcome at a Hospital Trust between 1stJanuary 2012 and 31stDecember 2017. Forty-four Bordatella pertussis patients were identified through clinical coding or microbiological confirmation. Five patients were excluded due to insufficient clinical data, duplication or community treatment. The remaining thirty-nine patients were evaluated by systematically reviewing their clinical notes; recording whether the patients were correctly investigated, treated and notified to Public Health England (PHE), as well as the patient’s clinical outcome. This information was corroborated with the PHE records of pertussis notifications over the same period. Results demonstrated that 31 (84%, n=37) patients were correctly investigated with either pernasal swabs, nasopharyngeal aspirates (NPA) or serological testing. 17 (46%, n=37) patients were treated correctly according to local guidelines. The remainder were non-adherent to guidelines generally due to choice, timing or duration of antibiotic. 8 (21%, n=39) patients had notification to PHE recorded in their clinical notes, well below the 23 (53%, n=43) cases that PHE were informed of according to their records. 11 (28%, n=39) patients were admitted to Paediatric Intensive Care Unit (PICU), 5 (13%, n=39) patients received Extracorporeal Membrane Oxygenation (ECMO) and 6 (15%, n=39) patients died. Mortality rate was 45% (n=11) for those admitted to PICU and 80% (n=5) for those who received ECMO. Further analysis showed a statistically significant increased average length of time between admission and diagnosis for those that died compared to those that survived (p=0.03). These findings show considerable room for improvement in the optimal treatment of pertussis patients and should inform future pertussis guidelines. In particular, greater emphasis should be put on patients with symptoms lasting >3 weeks, who were responsible for the majority of incorrect investigations and treatments. Furthermore, evidence suggests faster diagnosis of pertussis patients may lead to improved clinical outcome.

Background: Stress is associated with activation of the sympathetic nervous system, and can lead to lasting alterations in autonomic function and in extreme cases symptoms of posttraumatic stress disorder (PTSD). Vagal nerve stimulation (VNS) is a potentially useful tool as a modulator of autonomic nervous system function, however currently available implantable devices are limited by cost and inconvenience. Objective: The purpose of this study was to assess the effects of transcutaneous cervical VNS (tcVNS) on autonomic responses to stress. Methods: Using a double-blind approach, we investigated the effects of active or sham tcVNS on peripheral cardiovascular and autonomic responses to stress using wearable sensing devices in 24 healthy human participants with a history of exposure to psychological trauma. Participants were exposed to acute stressors over a three-day period, including personalized scripts of traumatic events, public speech, and mental arithmetic tasks. Results: tcVNS relative to sham applied immediately after traumatic stress resulted in a decrease in sympathetic function and modulated parasympathetic/sympathetic autonomic tone as measured by increased pre-ejection period (PEP) of the heart (a marker of cardiac sympathetic function) of 4.2 ms (95% CI 1.6–6.8 ms, p

Background:Some patients with rheumatoid arthritis (RA) have high disease activity scores (DAS) and low synovial inflammation, and others have high synovial inflammation and low DAS (subclinical synovitis)[1]. It would be clinically useful to identify blood biomarkers of synovial inflammation. Neutrophil-lymphocyte (NLR) and platelet-lymphocyte ratios (PLR) have been reported to distinguish RA patients with moderate/high DAS28 scores from low DAS28 [2]. However, it is not known if these inexpensive, accessible tests are associated with inflammation in synovial tissue at the histological level.Objectives:The objective of this study was to evaluate the relationship of pre-operative NLR and PLR with synovial inflammation of the operative joint in RA patients undergoing arthroplasty.Methods:230 patients meeting ACR/EULAR 1987 and/or 2010 criteria were recruited prior to elective total hip, knee, shoulder, and elbow replacement. Demographics, RA characteristics, medications, disease activity, and routine tests including complete blood tests (CBC) were collected pre-operatively. Hematoxylin and eosin (H&E) stains were prepared from the synovium of the operative joint and systematically scored by a pathologist as described previously [3]. Synovial lymphocytic inflammation was graded as none, mild, moderate, marked, or band-like. Linear regression was performed to distinguish differences in the NLR, PLR, and CRP in patients with synovial lymphocytic inflammation (SLI).Results:As expected, patients on glucocorticoids (GCs) had higher NLR (mean 5.52 (SD 7.68) vs mean 2.82 (SD 1.66) (pConclusion:NLR, PLR and CRP are associated with high synovial lymphocytic inflammation of the operative joint. This suggests that these inexpensive, routinely performed blood tests may be a useful blood biomarker of synovial inflammation.References:[1]Orange, D.E. et al. Histologic and Transcriptional Evidence of Subclinical Synovial Inflammation in Patients With Rheumatoid Arthritis in Clinical Remission. Arthritis Rheumatol. 71(7): 1034-1041 (2019).[2]Lee, Y.H. Association between the Neutrophil-to-lymphocyte Ratio, and Platelet-to-lymphocyte Ratio and Rheumatoid Arthritis and their Correlations with the Disease Activity: A Meta-analysis. J Rheum Dis. 25(3):169-178 (2018).[3]Orange, D. E. et al. Identification of Three Rheumatoid Arthritis Disease Subtypes by Machine Learning Integration of Synovial Histologic Features and RNA Sequencing Data. Arthritis Rheumatol. Hoboken NJ 70: 690–701 (2018).Table 1.Results from linear regressions evaluating the association of NLR, PLR, and CRP with synovial lymphocytic inflammation.Linear regression ResultsNLRPLRCRPSynovial Lymphocytic InflammationCoef (95% CI)Coef (95% CI)Coef (95% CI)NoneReferencereferencereferenceMild0.31 (-0.51, 1.13)26.54 (-8.83, 61.90)-1.00 (-2.37, 0.36)Moderate0.73 (-0.18, 1.64)28.66 (-10.22, 67.53)0.46 (-1.09, 2.01)Marked0.21 (-0.80, 1.22)24.62 (-22.80, 72.05)0.81 (-0.87, 2.49)Band-like1.92 (0.81, 3.02)80.42 (31.46, 129.38)2.32 (0.49, 4.16)OR= Odds ratio, Coef = Coefficient, NLR= neutrophil lymphocyte, PLR= platelet lymphocyte ratio, CRP= C-reactive proteinAll significant associations are bolded.Disclosure of Interests:Diyu Pearce-Fisher: None declared, Dana Orange Consultant of: Astra Zeneca/MedImmune and Pfizer, Bella Mehta Consultant of: Novartis, Deanna Jannat-Khah: None declared, Susan Goodman Consultant of: UCB, Grant/research support from: Novartis, Horizon Pharmaceuticals