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221. P175 TRANSLATION OF MINIMALLY INVASIVE ESOPHAGECTOMY FROM RANDOMIZED CONTROLLED TRIAL SETTING (TIME) TO NATIONAL PRACTICE (DUCA) IN NETHERLANDS

Author

B Hanna George, I van Berge Henegouwen Mark, van der Peet Donald, A Cuesta Miguel, Gisbertz Suzanne, Straatman Jennifer, Ni Melody, and R Markar Sheraz

Subjects
medicine.medical_specialty, Randomized controlled trial, law, business.industry, General surgery, Invasive esophagectomy, Gastroenterology, medicine, Setting time, General Medicine, business, law.invention
Abstract

Aims The TIME trial showed reduced pulmonary complications from minimally invasive esophagectomy (MIE) over an open approach, and led to widespread adoption of MIE in the Netherlands. The aim of this study was to compare clinical outcomes from minimally invasive esophagectomy in the DUCA (national dataset) and the TIME trial (RCT) for transthoracic esophagectomy1. Methods Original patient data from the TIME trial1 was extracted along-with data from the Dutch National Cancer Audit (DUCA) (2011-2017). Initially univariate analysis was used to compare patient and tumor demographics and clinical and pathological outcomes from patients receiving MIE in the TIME trial and in the DUCA-dataset. Secondly multivariate analysis, with adjustment patient and tumor factors, was performed for the effect of MIE vs. Open esophagectomy on clinical outcomes in both datasets. Thirdly the datasets were combined and multivariate analysis, was performed for the effect of patient inclusion in TIME trial or DUCA-dataset. Results 115 patients from TIME (59 MIE vs. 56 open) and 4605 patients from the DUCA-dataset (2652 MIE vs. 1953 open) were included. Univariate analysis showed, in TIME trial, MIE reduced postoperative complications and length of hospital stay. However in the DUCA-dataset, MIE increased postoperative complications, re-intervention rate and length of hospital stay, however pathological benefits included increased proportion of R0 margin and lymph nodes harvested. Multivariate analysis confirmed the TIME data showed MIE reduced postoperative complications (OR=0.38, 95%CI 0.16–0.90). In the DUCA-dataset, MIE was associated with increased postoperative complications (OR=1.37, 95%CI 1.20–1.55), re-intervention (OR=1.84, 95%CI 1.57–2.14), and length of hospital stay (Coeff=1.57, 95%CI 0.06–3.08). Pathological benefits to MIE in the DUCA-dataset included a reduction in proportion of R1 margin, and increased lymph node harvest. Multivariate analysis of the combined dataset, showed inclusion in the TIME trial was associated with a reduction in postoperative complications (OR=0.23, 95%CI 0.15–0.36) and reoperation rate (OR=0.34, 95%CI 0.17–0.66). Conclusions MIE when adopted nationally outside the TIME-trial, was associated with an increase in postoperative complications and reoperation rate, which may reflect surgeons on a national level going through their proficiency-gain curve in the technique and outside of expert MIE centers.

Published
2019

222. Technique of open and minimally invasive intrathoracic reconstruction following esophagectomy—an expert consensus based on a modified Delphi process

Author

Bartella, Isabel, primary, Fransen, Laura F C, additional, Gutschow, Christian A, additional, Bruns, Christiane J, additional, van Berge Henegouwen, Mark L, additional, Chaudry, M Asif, additional, Cheong, Edward, additional, Cuesta, Miguel A, additional, Van Daele, Elke, additional, Gisbertz, Suzanne S, additional, van Hillegersberg, Richard, additional, Hölscher, Arnulf, additional, Mercer, Stuart, additional, Moorthy, Krishna, additional, Nafteux, Philippe, additional, Nilsson, Magnus, additional, Pattyn, Piet, additional, Piessen, Guillaume, additional, Räsanen, Jari, additional, Rosman, Camiel, additional, Ruurda, Jelle P, additional, Schneider, Paul M, additional, Sgromo, Bruno, additional, Nieuwenhuijzen, Grard A, additional, Luyer, Misha D P, additional, and Schröder, Wolfgang, additional

Published
2021
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230. Correction to: Open versus minimally invasive total gastrectomy after neoadjuvant chemotherapy: results of a European randomized trial

Author

van der Wielen, Nicole, primary, Straatman, Jennifer, additional, Daams, Freek, additional, Rosati, Riccardo, additional, Parise, Paolo, additional, Weitz, Jürgen, additional, Reissfelder, Christoph, additional, Diez del Val, Ismael, additional, Loureiro, Carlos, additional, Parada-González, Purificación, additional, Pintos-Martínez, Elena, additional, Mateo Vallejo, Francisco, additional, Medina Achirica, Carlos, additional, Sánchez-Pernaute, Andrés, additional, Ruano Campos, Adriana, additional, Bonavina, Luigi, additional, Asti, Emanuele L. G., additional, Alonso Poza, Alfredo, additional, Gilsanz, Carlos, additional, Nilsson, Magnus, additional, Lindblad, Mats, additional, Gisbertz, Suzanne S., additional, van Berge Henegouwen, Mark I., additional, Fumagalli Romario, Uberto, additional, De Pascale, Stefano, additional, Akhtar, Khurshid, additional, Jaap Bonjer, H., additional, Cuesta, Miguel A., additional, and van der Peet, Donald L., additional

Published
2020
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231. Open versus minimally invasive total gastrectomy after neoadjuvant chemotherapy: results of a European randomized trial

Author

van der Wielen, Nicole, primary, Straatman, Jennifer, additional, Daams, Freek, additional, Rosati, Riccardo, additional, Parise, Paolo, additional, Weitz, Jürgen, additional, Reissfelder, Christoph, additional, Diez del Val, Ismael, additional, Loureiro, Carlos, additional, Parada-González, Purificación, additional, Pintos-Martínez, Elena, additional, Mateo Vallejo, Francisco, additional, Medina Achirica, Carlos, additional, Sánchez-Pernaute, Andrés, additional, Ruano Campos, Adriana, additional, Bonavina, Luigi, additional, Asti, Emanuele L. G., additional, Alonso Poza, Alfredo, additional, Gilsanz, Carlos, additional, Nilsson, Magnus, additional, Lindblad, Mats, additional, Gisbertz, Suzanne S., additional, van Berge Henegouwen, Mark I., additional, Fumagalli Romario, Uberto, additional, De Pascale, Stefano, additional, Akhtar, Khurshid, additional, Jaap Bonjer, H., additional, Cuesta, Miguel A., additional, and van der Peet, Donald L., additional

Published
2020
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246. Distribution of lymph node metastases in esophageal carcinoma [TIGER study] : Study protocol of a multinational observational study

Author

Hagens, Eliza R.C., Van Berge Henegouwen, Mark I., Van Sandick, Johanna W., Cuesta, Miguel A., Van Der Peet, Donald L., Heisterkamp, Joos, Nieuwenhuijzen, Grard A.P., Rosman, Camiel, Scheepers, Joris J.G., Sosef, Meindert N., Van Hillegersberg, Richard, Lagarde, Sjoerd M., Nilsson, Magnus, Räsänen, Jari, Nafteux, Philippe, Pattyn, Piet, Hölscher, Arnulf H., Schröder, Wolfgang, Schneider, Paul M., Mariette, Christophe, Castoro, Carlo, Bonavina, Luigi, Rosati, Riccardo, De Manzoni, Giovanni, Mattioli, Sandro, Garcia, Josep Roig, Pera, Manuel, Griffin, Michael, Wilkerson, Paul, Chaudry, M. Asif, Sgromo, Bruno, Tucker, Olga, Cheong, Edward, Moorthy, Krishna, Walsh, Thomas N., Reynolds, John, Tachimori, Yuji, Inoue, Haruhiro, Matsubara, Hisahiro, Kosugi, Shin Ichi, Chen, Haiquan, Law, Simon Y.K., Pramesh, C. S., Puntambekar, Shailesh P., Murthy, Sudish, Linden, Philip, Hofstetter, Wayne L., Kuppusamy, Madhan K., Shen, K. Robert, Darling, Gail E., Sabino, Flávio D., Grimminger, Peter P., Meijer, Sybren L., Bergman, Jacques J.G.H.M., Hulshof, Maarten C.C.M., Van Laarhoven, Hanneke W.M., Mearadji, Banafsche, Bennink, Roel J., Annema, Jouke T., Dijkgraaf, Marcel G.W., Gisbertz, Suzanne S., Hagens, Eliza R.C., Van Berge Henegouwen, Mark I., Van Sandick, Johanna W., Cuesta, Miguel A., Van Der Peet, Donald L., Heisterkamp, Joos, Nieuwenhuijzen, Grard A.P., Rosman, Camiel, Scheepers, Joris J.G., Sosef, Meindert N., Van Hillegersberg, Richard, Lagarde, Sjoerd M., Nilsson, Magnus, Räsänen, Jari, Nafteux, Philippe, Pattyn, Piet, Hölscher, Arnulf H., Schröder, Wolfgang, Schneider, Paul M., Mariette, Christophe, Castoro, Carlo, Bonavina, Luigi, Rosati, Riccardo, De Manzoni, Giovanni, Mattioli, Sandro, Garcia, Josep Roig, Pera, Manuel, Griffin, Michael, Wilkerson, Paul, Chaudry, M. Asif, Sgromo, Bruno, Tucker, Olga, Cheong, Edward, Moorthy, Krishna, Walsh, Thomas N., Reynolds, John, Tachimori, Yuji, Inoue, Haruhiro, Matsubara, Hisahiro, Kosugi, Shin Ichi, Chen, Haiquan, Law, Simon Y.K., Pramesh, C. S., Puntambekar, Shailesh P., Murthy, Sudish, Linden, Philip, Hofstetter, Wayne L., Kuppusamy, Madhan K., Shen, K. Robert, Darling, Gail E., Sabino, Flávio D., Grimminger, Peter P., Meijer, Sybren L., Bergman, Jacques J.G.H.M., Hulshof, Maarten C.C.M., Van Laarhoven, Hanneke W.M., Mearadji, Banafsche, Bennink, Roel J., Annema, Jouke T., Dijkgraaf, Marcel G.W., and Gisbertz, Suzanne S.

Published
2019

247. Figuras ridículas: la pintura de género en España en el siglo XVII

Author

Hervás Crespo, Gonzalo, Hermoso Cuesta, Miguel, Hervás Crespo, Gonzalo, and Hermoso Cuesta, Miguel

Abstract

El presente trabajo aborda la llegada y desarrollo de la pintura de género a España, desde finales del siglo XVI hasta las primeras décadas del XVII, así como su conflictivo encaje dentro del estamento artístico español. A pesar de resultar un asunto codiciado y coleccionado por una élite cultivada, los pintores españoles optaron por mantenerse al margen de su práctica. De esta manera, un novedoso género pictórico nacido en Flandes hacia la mitad del siglo XVI, trasladado de forma rápida al norte de Italia donde adquiere una entidad propia, no termina de asentarse en España, incluso cuando estos territorios donde surge (Flandes y Lombardía) pertenecen a la corona española. Es evidente que en su rechazo se concitan una serie de factores, tanto políticos como sociales, religiosos y estéticos, todos ellos explorados a lo largo de esta investigación. Resulta asimismo paradójico que los dos pintores españoles más importantes de su tiempo, como son Diego Velázquez (1599-1660) y Bartolomé Esteban Murillo (1617-1682), encontraran precisamente en la pintura de género un cauce de expresión privilegiado, generando una serie de pinturas sin parangón en la Europa Moderna...

Published
2019

248. Distribution of lymph node metastases in esophageal carcinoma [TIGER study]: Study protocol of a multinational observational study

Author

Divisie Beeld & Oncologie, Cancer, Hagens, Eliza R.C., Van Berge Henegouwen, Mark I., Van Sandick, Johanna W., Cuesta, Miguel A., Van Der Peet, Donald L., Heisterkamp, Joos, Nieuwenhuijzen, Grard A.P., Rosman, Camiel, Scheepers, Joris J.G., Sosef, Meindert N., Van Hillegersberg, Richard, Lagarde, Sjoerd M., Nilsson, Magnus, Räsänen, Jari, Nafteux, Philippe, Pattyn, Piet, Hölscher, Arnulf H., Schröder, Wolfgang, Schneider, Paul M., Mariette, Christophe, Castoro, Carlo, Bonavina, Luigi, Rosati, Riccardo, De Manzoni, Giovanni, Mattioli, Sandro, Garcia, Josep Roig, Pera, Manuel, Griffin, Michael, Wilkerson, Paul, Chaudry, M. Asif, Sgromo, Bruno, Tucker, Olga, Cheong, Edward, Moorthy, Krishna, Walsh, Thomas N., Reynolds, John, Tachimori, Yuji, Inoue, Haruhiro, Matsubara, Hisahiro, Kosugi, Shin Ichi, Chen, Haiquan, Law, Simon Y.K., Pramesh, C. S., Puntambekar, Shailesh P., Murthy, Sudish, Linden, Philip, Hofstetter, Wayne L., Kuppusamy, Madhan K., Shen, K. Robert, Darling, Gail E., Sabino, Flávio D., Grimminger, Peter P., Meijer, Sybren L., Bergman, Jacques J.G.H.M., Hulshof, Maarten C.C.M., Van Laarhoven, Hanneke W.M., Mearadji, Banafsche, Bennink, Roel J., Annema, Jouke T., Dijkgraaf, Marcel G.W., Gisbertz, Suzanne S., Divisie Beeld & Oncologie, Cancer, Hagens, Eliza R.C., Van Berge Henegouwen, Mark I., Van Sandick, Johanna W., Cuesta, Miguel A., Van Der Peet, Donald L., Heisterkamp, Joos, Nieuwenhuijzen, Grard A.P., Rosman, Camiel, Scheepers, Joris J.G., Sosef, Meindert N., Van Hillegersberg, Richard, Lagarde, Sjoerd M., Nilsson, Magnus, Räsänen, Jari, Nafteux, Philippe, Pattyn, Piet, Hölscher, Arnulf H., Schröder, Wolfgang, Schneider, Paul M., Mariette, Christophe, Castoro, Carlo, Bonavina, Luigi, Rosati, Riccardo, De Manzoni, Giovanni, Mattioli, Sandro, Garcia, Josep Roig, Pera, Manuel, Griffin, Michael, Wilkerson, Paul, Chaudry, M. Asif, Sgromo, Bruno, Tucker, Olga, Cheong, Edward, Moorthy, Krishna, Walsh, Thomas N., Reynolds, John, Tachimori, Yuji, Inoue, Haruhiro, Matsubara, Hisahiro, Kosugi, Shin Ichi, Chen, Haiquan, Law, Simon Y.K., Pramesh, C. S., Puntambekar, Shailesh P., Murthy, Sudish, Linden, Philip, Hofstetter, Wayne L., Kuppusamy, Madhan K., Shen, K. Robert, Darling, Gail E., Sabino, Flávio D., Grimminger, Peter P., Meijer, Sybren L., Bergman, Jacques J.G.H.M., Hulshof, Maarten C.C.M., Van Laarhoven, Hanneke W.M., Mearadji, Banafsche, Bennink, Roel J., Annema, Jouke T., Dijkgraaf, Marcel G.W., and Gisbertz, Suzanne S.

Published
2019

249. Bowel Obstruction and Ventral Hernia After Laparoscopic Versus Open Surgery for Rectal Cancer in A Randomized Trial (COLOR II)

Author

Petersson, Josefin, Koedam, Thomas W, Bonjer, H Jaap, Andersson, John, Angenete, Eva, Bock, David, Cuesta, Miguel A, Deijen, Charlotte L, Fürst, Alois, Lacy, Antonio M, Rosenberg, Jacob, Haglind, Eva, Petersson, Josefin, Koedam, Thomas W, Bonjer, H Jaap, Andersson, John, Angenete, Eva, Bock, David, Cuesta, Miguel A, Deijen, Charlotte L, Fürst, Alois, Lacy, Antonio M, Rosenberg, Jacob, and Haglind, Eva

Abstract

OBJECTIVE: The aim of this study was to evaluate the risk of bowel obstruction, incisional, and parastomal hernia following laparoscopic versus open surgery for rectal cancer.SUMMARY BACKGROUND DATA: Laparoscopic surgery for rectal cancer has been adopted worldwide, after trials reported similar oncological outcomes compared with open surgery. Little is known about long-term morbidity, including bowel obstruction, incisional, and parastomal hernia following surgery.METHODS: Patients included in the international, multicenter, noninferior, open-label, randomized COLOR II trial were followed for five years. Primary endpoint was local recurrence at 3-year follow-up. Secondary endpoints included bowel obstruction, incisional and parastomal hernia within 5 years, and the current article reports on these secondary endpoints.RESULTS: All 1044 patients included in the COLOR II trial were analyzed. There was no difference in risk of bowel obstruction, incisional, or parastomal hernia following laparoscopic or open surgery for rectal cancer.CONCLUSION: Based on long-term morbidity outcomes, laparoscopic surgery for rectal cancer could be considered a routine technique as there are no differences with open surgery.

Published
2019

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