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1,318 results on '"Cowan M."'

211. Allogeneic hematopoietic SCT for alpha-mannosidosis: an analysis of 17 patients

Author

Mynarek, M, primary, Tolar, J, additional, Albert, M H, additional, Escolar, M L, additional, Boelens, J J, additional, Cowan, M J, additional, Finnegan, N, additional, Glomstein, A, additional, Jacobsohn, D A, additional, Kühl, J S, additional, Yabe, H, additional, Kurtzberg, J, additional, Malm, D, additional, Orchard, P J, additional, Klein, C, additional, Lücke, T, additional, and Sykora, K-W, additional

Published
2011
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219. FLOW CHAMBER STUDY OF THE ADHESION OF PREVOTELLA-INTERMEDIA TO GLASS AFTER PRECONDITIONING WITH MUTANS STREPTOCOCCAL SPECIES - KINETICS AND SPATIAL ARRANGEMENT

Author

COWAN, M, BUSSCHER, HJ, University of Groningen, Man, Biomaterials and Microbes (MBM), and Personalized Healthcare Technology (PHT)

Subjects
stomatognathic diseases, stomatognathic system, SURFACE, PARALLEL-PLATE, ORAL BACTERIA, PARTICLES, CELL, COAGGREGATION, DEPOSITION, BACTEROIDES-GINGIVALIS, ECOLOGY
Abstract

The adhesion kinetics and spatial arrangement of a clinical isolate of Prevotella intermedia on bare glass and on glass which had been previously exposed to Streptococcus rattus or Streptococcus cricetus were studied using a parallel plate flow system and image analysis. When S. cricetus was the preconditioning organism the initial deposition rate and efficiency of P. intermedia were reduced even though very few S. cricetus adhered during flow with P. intermedia. Preconditioning with S. rattus had less effect on the adhesion behaviour of P. intermedia despite the fact that more S. rattus cells adhered than S. cricetus cells. Small differences in both the stationary state adhesion and in the final spatial arrangements were evident under the three experimental conditions. S. cricetus negatively influences initial deposition of subsequent P. intermedia adhesion possibly by the production of a biosurfactant or by leaving 'microbial footprints'. This interference is eventually overcome resulting in a similar stationary state adhesion of P. intermedia as found without S. cricetus preconditioning. Furthermore, the flow chamber system employed here proved uniquely suited for studying cell-cell interactions in initial adhesion.

Published
1993

230. Stem cell transplantation in patients with severe congenital neutropenia without evidence of leukemic transformation.

Author

UCL - MD/GYPE - Département de gynécologie, d'obstétrique et de pédiatrie, Zeidler, C, Welte, K, Barak, Y, Barriga, F, Bolyard, A A, Boxer, L, Cornu, Guy, Cowan, M J, Dale, D C, Flood, T, Freedman, M, Gadner, H., Mandel, H., O'Reilly, R J, Ramenghi, U, Reiter, A, Skinner, R, Vermylen, Christiane, Levine, J E, UCL - MD/GYPE - Département de gynécologie, d'obstétrique et de pédiatrie, Zeidler, C, Welte, K, Barak, Y, Barriga, F, Bolyard, A A, Boxer, L, Cornu, Guy, Cowan, M J, Dale, D C, Flood, T, Freedman, M, Gadner, H., Mandel, H., O'Reilly, R J, Ramenghi, U, Reiter, A, Skinner, R, Vermylen, Christiane, and Levine, J E

Abstract

Severe congenital neutropenia (CN) (Kostmann syndrome) is a hematologic disorder characterized by a maturation arrest of myelopoiesis at the promyelocyte/myelocyte stage of development. This arrest results in severe neutropenia leading to absolute neutrophil counts (ANC) below 0.2 x 10(9)/L associated with severe bacterial infections from early infancy. Data on over 300 patients with CN collected by the Severe Chronic Neutropenia International Registry (SCNIR) beginning in 1994 indicate that more than 90% of these patients respond to recombinant human granulocyte-colony stimulating factor (r-HuG-CSF) treatment with an ANC greater than 1. 0 x 10(9)/L. For patients who are refractory to r-HuG-CSF treatment and continue to have severe and often life-threatening bacterial infections, hematopoietic stem cell transplantation is the only currently available treatment. We report on a total of 11 patients with CN reported to the SCNIR who underwent transplantation for reasons other than malignant transformation between 1976 and 1998. Of these patients, 8 were nonresponders or showed only partial response to r-HuG-CSF treatment with ongoing infections. Results from these patients suggest that transplantation of stem cells from an HLA-identical sibling is beneficial for patients refractory to r-HuG-CSF. (Blood. 2000;95:1195-1198)

Published
2000

242. Phononic crystals

Author

Page, J. H., primary, Sukhovich, Alexey, additional, Yang, Suxia, additional, Cowan, M. L., additional, Van Der Biest, Fran�ois, additional, Tourin, Arnaud, additional, Fink, Mathias, additional, Liu, Zhengyou, additional, Chan, C. T., additional, and Sheng, Ping, additional

Published
2004
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