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We are coming to believe that stellar populations in globular clusters are not as simple as they were once thought to be. A growing amount of photometric and spectroscopic evidence shows that globular clusters host at least two different stellar populations. In our contribution to these proceedings we present the first results of a survey we are conducting to look for the presence of multiple populations in a significant number of Galactic globular clusters, using the Str��mgren system. We intend to photometrically separate these populations and characterize their radial distributions and extensions., 4 pages, 2 figures. To appear in the proceedings of "Reading the book of globular clusters with the lens of stellar evolution", in the Memorie della Societa Astronomica Italiana

The software engineering is a relatively new discipline compared to other sciences, since the origins of the term itself dates back to the years 1968 and 1969. At present, the market and the software industry have a significant relevance in several countries of the world; however, although Mexico is immersed in this race, has not even reached the level of success achieved in other countries in this sector. This paper presents an overview of the situation that keeps the practice of software engineering in Mexico, with emphasis on the academic realm. It shows a compilation of scientific research activity carried out in universities, as well as a brief analysis of undergraduate educational programs including the software engineering discipline . At the end, future work to be done is proposed in order to find a point of convergence between academia and industry, and also to support the flourishing of this business which somehow will have a positive impact on the economy of our country.

An Atmospheric Monitoring System (AMS) is mandatory and a key element of a space-based mission which aims to detect Ultra-High Energy Cosmic Rays (UHECR). JEM-EUSO has a dedicated atmospheric monitoring system that plays a fundamental role in our understanding of the atmospheric conditions in the Field of View (FoV) of the telescope. Our AMS consists of an infrared camera and a LIDAR device that are being fully designed with space qualification to fulfil the scientific requirements of this space mission. This AMS will provide information of the cloud cover in the FoV of JEM-EUSO, as well as measurements of the cloud top altitudes with an accuracy of 500 m and the optical depth profile of the atmosphere transmittance in the direction of each air shower with an accuracy of 0.15 degree and a resolution of 500 m. This will ensure that the energy of the primary UHECR and the depth of maximum development of the EAS (Extensive Air Shower) are measured with an accuracy better than 30% and 120 g/cm2, for EAS occurring either in the clear sky or with the EAS depth of maximum development above optically thick cloud layers. Moreover novel stereoscopic and radiometric retrieval techniques are under development to infer the Cloud Top Height (CTH) from the brightness temperature patterns obtained from the infrared camera.

Results are presented on the performance of Adaptive Neuro-Fuzzy Inference system (ANFIS) for wind velocity forecasts in the Isthmus of Tehuantepec region in the state of Oaxaca, Mexico. The data bank was provided by the meteorological station located at the University of Isthmus, Tehuantepec campus, and this data bank covers the period from 2008 to 2011. Three data models were constructed to carry out 16, 24 and 48 hours forecasts using the following variables: wind velocity, temperature, barometric pressure, and date. The performance measure for the three models is the mean standard error (MSE). In this work, performance analysis in short-term prediction is presented, because it is essential in order to define an adequate wind speed model for eolian parks, where a right planning provide economic benefits., 9 pages, 11 figures, 1 table; IJCSI International Journal of Computer Science Issues, Vol. 9, Issue 5, No 3, September 2012. ISSN (Online): 1694-0814. www.IJCSI.org

The single photon transport through a one dimensional array of cavities is studied theoretically. Analytical expressions of the reflection and transmission are given. The transmission shows an energy spectrum with forbidden and allowed bands that depends on the detuning parameter of the system. We show that the allowed miniband is formed due to the indirect coupling between the atoms in each cavity. In addition, the band edges can be controlled by the degree of detuning of the level of the atoms. We discuss the analogy between this phenomenon with the Fano and Dicke effects., 4 pages, 4 figures

Given a K��hler manifold $M$ endowed with a Hamiltonian Killing vector field $Z$, we construct a conical K��hler manifold $\hat{M}$ such that $M$ is recovered as a K��hler quotient of $\hat{M}$. Similarly, given a hyper-K��hler manifold $(M,g,J_1,J_2,J_3)$ endowed with a Killing vector field $Z$, Hamiltonian with respect to the K��hler form of $J_1$ and satisfying $\mathcal{L}_ZJ_2= -2J_3$, we construct a hyper-K��hler cone $\hat{M}$ such that $M$ is a certain hyper-K��hler quotient of $\hat{M}$. In this way, we recover a theorem by Haydys. Our work is motivated by the problem of relating the supergravity c-map to the rigid c-map. We show that any hyper-K��hler manifold in the image of the c-map admits a Killing vector field with the above properties. Therefore, it gives rise to a hyper-K��hler cone, which in turn defines a quaternionic K��hler manifold. Our results for the signature of the metric and the sign of the scalar curvature are consistent with what we know about the supergravity c-map., conjecture replaced by reference

Laser-induced nuclear recollisions following $��$ decay in the presence of an intense laser field are investigated theoretically. We show that while an intense optical laser does not influence notably the tunneling rate in $��$ decay, it can completely change the $��$ particle spectrum. For intensities of $10^{22}-10^{23}$ W/cm$^{2}$, the field is strong enough to induce recollisions between the emitted $��$ particle and the daughter nucleus. The energy gained by the $��$ particle in the field can reach 20 MeV and suffice to trigger several types of nuclear reactions on a femtosecond time scale. Similar conclusions can be drawn about laser-induced recollisions after proton emission. Prospects for the experimental realization of laser-induced nuclear recollisions are discussed., 5 pages, 3 figures; v2 extended the motivation and discussion about experimental feasibility; results unchanged

An increasing amount of spectroscopic and photometric evidence is showing that the stellar populations of globular clusters are not as simple as they have been considered for many years. The presence of at least two different populations of stars is being discovered in a growing number of globular clusters, both in our Galaxy and in others. We have started a series of observations of Galactic globular clusters using the Str��mgren photometric system in order to find the signatures of these multiple populations and establish their presence in a more complete sample of globular clusters in the Milky Way, and to study their radial distributions and extensions. We present here the first results of our survey., 4 pages, 2 figures. To appear in the proceedings of "EWASS 2012- Symposium 6: Stellar Populations 55 years after the Vatican conference", in the Memorie della Societa Astronomica Italiana

Using in organello footprint analysis, we demonstrate that within human placental mitochondria there is a high level of protein-DNA binding at regularly phased intervals throughout a 500-bp region encompassing the D-loop DNA origins and two promoter regions. Comparison with in vitro DNase I protection studies indicates that this protein-DNA interaction is due to non-sequence-specific binding by human mitochondrial transcription factor A (h-mtTFA). Since h-mtTFA can bend and wrap DNA, like its yeast counterpart ABF2, a primary function of h-mtTFA appears to be specific packaging of the mitochondrial DNA control region in vivo. Intervals of protein binding coincide with the spacing of the RNA start sites and prominent D-loop DNA 5' ends, suggesting a role for phased h-mtTFA binding in defining transcription and H-strand DNA replication origins. Significant protein-DNA interaction was also observed within the human homolog of conserved sequence block 1, both in organello and in vitro, using purified h-mtTFA.

A series of inhibitors of mammalian 15-lipoxygenase (15-LO) based on a 3,4,5-tri-substituted pyrazole scaffold is described. Replacement of a sulfonamide functionality in the lead series with a sulfamide group resulted in improved physicochemical properties generating analogs with enhanced inhibition in cell-based and whole blood assays.

We prove that, given a certain isometric action of a two-dimensional Abelian group A on a quaternionic K��hler manifold M which preserves a submanifold N\subset M, the quotient M'=N/A has a natural K��hler structure. We verify that the assumptions on the group action and on the submanifold N\subset M are satisfied for a large class of examples obtained from the supergravity c-map. In particular, we find that all quaternionic K��hler manifolds M in the image of the c-map admit an integrable complex structure compatible with the quaternionic structure, such that N\subset M is a complex submanifold. Finally, we discuss how the existence of the K��hler structure on M' is required by the consistency of spontaneous {\cal N}=2 to {\cal N}=1 supersymmetry breaking., 36 pages

A methylation protection assay was used in a novel manner to demonstrate a specific bovine protein-mitochondrial DNA (mtDNA) interaction within the organelle (in organello). The protected domain, located near the D-loop 3' end, encompasses a conserved termination-associated sequence (TAS) element which is thought to be involved in the regulation of mtDNA synthesis. In vitro footprinting studies using a bovine mitochondrial extract and a series of deleted mtDNA templates identified a approximately 48-kDa protein which binds specifically to a single TAS element also protected within the mitochondrion. Because other TAS-like elements located in close proximity to the protected region did not footprint, protein binding appears to be highly sequence specific. The in organello and in vitro data, together, provide evidence that D-loop formation is likely to be mediated, at least in part, through a trans-acting factor binding to a conserved sequence element located 58 bp upstream of the D-loop 3' end.

Detailed study of mammalian mitochondrial transcriptional and replicative mechanisms is currently limited to in vitro analyses, requiring isolation and reassembly of functional components to mimic the in vivo process. To complement these studies and begin understanding the intracellular function of mitochondrial DNA (mtDNA) regulatory regions, we developed in organello footprinting to investigate protein-DNA interactions within the mitochondrion. Using a methylation protection technique and mitochondria isolated from bovine brain tissue, we analyzed five domains believed critical for regulating mtDNA function. Near equivalent protein-DNA interactions were seen upstream of both light and heavy strand RNA start sites at positions consistent with those observed for human mitochondrial transcription factor 1 DNA binding in vitro. Downstream of the 16 S rRNA gene, a high level of protein occupancy was detected within the bovine homologue of the human tridecamer sequence required for attenuation of transcription in vitro. Immediately upstream of the origin of heavy strand replication, a novel site of protein-mtDNA interaction was observed within conserved sequence block 1, suggesting its potential as a regulatory element involved in initiation of heavy strand DNA synthesis. Unlike regions associated with the origin of heavy strand replication, protein-mtDNA interaction was not detected at the origin of light strand replication or within flanking tRNA genes.

Howler monkeys (genus Alouatta) comprise twelve species of leaf-eating New World monkeys that range from southern Mexico through northern Argentina. This genus is the most widespread of any New World primate taxa, and can be found to inhabit a range of forest types from undisturbed rainforest to severely anthropogenically impacted forest fragments. Although there have been many studies on individual species of howler monkeys, this book is the first comprehensive volume to place information on howler behavior and biology within a theoretical framework of ecological and social adaptability. This is the second of two volumes devoted to the genus Alouatta. This volume: Examines behavioral and physiological mechanisms that enable howler monkeys to exploit highly disturbed and fragmented habitats Presents models of howler monkey diet, social organization, and mating systems that can also inform researchers studying Old World colobines, apes, and other tropical mammals These goals are achieved in a collection of chapters written by a distinguished group of scientists on the feeding ecology, behavior, mating strategies, and management and conservation of howlers. This book also contains chapters on the howler microbiome, the concept of behavioral variability, sexual selection, and the role of primates in forest regeneration.

This volume contains a selection of the best papers presented at the 8th International Conference on Industrial Engineering and Industrial Management, XX International Conference on Industrial Engineering and Operations Management, and International IIE Conference 2014, hosted by ADINGOR, ABEPRO and the IIE, whose mission is to promote links between researchers and practitioners from different branches, to enhance an interdisciplinary perspective of industrial engineering and management. The conference topics covered: operations research, modelling and simulation, computer and information systems, operations research, scheduling and sequencing, logistics, production and information systems, supply chain and logistics, transportation, lean management, production planning and control, production system design, reliability and maintenance, quality management, sustainability and eco-efficiency, marketing and consumer behavior, business administration and strategic management, economic and financial management, technological and organizational innovation, strategy and entrepreneurship, economics engineering, enterprise engineering, global operations and cultural factors, operations strategy and performance, management social responsibility, environment and sustainability. This book will be of interest to researchers and practitioners working in any of the fields mentioned above.

This book provides a general overview of several concepts of synchronization and brings together related approaches to secure communication in chaotic systems. This is achieved using a combination of analytic, algebraic, geometrical and asymptotical methods to tackle the dynamical feedback stabilization problem. In particular, differential-geometric and algebraic differential concepts reveal important structural properties of chaotic systems and serve as guide for the construction of design procedures for a wide variety of chaotic systems. The basic differential algebraic and geometric concepts are presented in the first few chapters in a novel way as design tools, together with selected experimental studies demonstrating their importance. The subsequent chapters treat recent applications. Written for graduate students in applied physical sciences, systems engineers, and applied mathematicians interested in synchronization of chaotic systems and in secure communications, this self-contained text requires only basic knowledge of integer ordinary and fractional ordinary differential equations. Design applications are illustrated with the help of several physical models of practical interest.

Howler monkeys (genus Alouatta) comprise twelve species of leaf-eating New World monkeys that range from southern Mexico through northern Argentina. This genus is the most widespread of any New World primate taxa, and can be found to inhabit a range of forest types from undisturbed rainforest to severely anthropogenically impacted forest fragments. Although there have been many studies on individual species of howler monkeys, this book is the first comprehensive volume to place information on howler behavior and biology within a theoretical framework of ecological and social adaptability. This is the first of two companion volumes devoted to the genus Alouatta. This volume: Provides new and original empirical and theoretical research on howler monkeys Presents evolutionary and adaptive explanations for the ecological success of howler monkeys Examines howler behavior and ecology within a comparative framework These goals are achieved in a collection of chapters written by a distinguished group of scientists on the evolutionary history, paleontology, taxonomy, genetics, morphology, physiology, and anatomy of howlers. This volume also contains chapters on ethnoprimatology, conservation, and howlers as vectors of infectious diseases.

This book provides information relevant for the conservation of biodiversity and the sound management of the coastal and forest ecosystems of the Yucatan Peninsula in the face of global change. Various aspects of the biodiversity of the Yucatan Peninsula are analyzed in an integrative manner, including phenological, ecophysiological, ecological and conservation aspects of plants and animals and their relationships with humans in coastal and forest ecosystems. .

We report the existence of stable symmetric vortex-type solutions for two-dimensional nonlinear discrete dissipative systems governed by a cubic-quintic complex Ginzburg-Landau equation. We construct a whole family of vortex solitons with a topological charge S = 1. Surprisingly, the dynamical evolution of unstable solutions of this family does not alter significantly their profile, instead their phase distribution completely changes. They transform into two-charges swirl-vortex solitons. We dynamically excite this novel structure showing its experimental feasibility., 4 pages, 20 figures

"The perception and use of insects by the residents of Ribeir??o da Ilha, Florian??polis, SC, Brazil. This work presents the perception of the residents of Ribeir??o da Ilha, Florian??polis, Santa Catarina Island, about the insects and the distinct uses made of them. The study was carried out between August and October of 2007 through semi-structured interviews with 50 residents of the community. The ethnocategory ???Insect??? is composed by 16 animals such as bees, cockroaches, beetles, spiders, snakes and others. This category is mostly seen negatively by the local population, or causes a sensation of fear and disgust. The knowledge about the use of insects is wide and it is related with ludic, decorative, alimentary and medicinal usages, as well as with forecasting the weather and earning money. However, nowadays only three uses are practiced by the community: consumption of honey in food, employment of bee stings to cure rheumatism, and butterflies for decoration."

We present a theoretical calibration of the RR Lyrae period-luminosity-color and period-color-color relations in the multiband uvby Stroemgren photometric system. Our theoretical work is based on calculations of synthetic horizontal branches (HBs) for four different metallicities, fully taking into account evolutionary effects for a wide range in metallicities and HB morphologies. While our results show that "pure" period-luminosity and period-color relations do not exist in the Stroemgren system, which is due to the large scatter that is brought about by evolutionary effects when the uvby bandpasses are used, they also reveal that such scatter can be almost completely taken into account by incorporating Stroemgren pseudo-color [C_0 = (u-v)_0 - (v-b)_0] terms into those equations, thus leading to tight period-luminosity-{\em pseudo}-color (PLpsC) and period-color-{\em pseudo}-color (PCpsC) relations. We provide the latter in the form of analytical fits, so that they can be applied with high precision even in the case of field stars. In view of the very small sensitivity of C_0 to interstellar reddening, our PLpsC and PCpsC relations should be especially useful for the derivation of high-precision distance and reddening values. In this sense, we carry out a first application of our relations to field RR Lyrae stars, finding evidence that the stars RR Lyr, SU Dra, and SS Leo -- but not SV Hya -- are somewhat overluminous (by amounts ranging from ~0.05 to 0.20 mag in y, and thus V) with respect to the average for other RR Lyrae stars of similar metallicity., 10 pages (emulateapj style), 8 figures. To appear in ApJS

We give an intrinsic definition of (affine very) special real manifolds and realise any such manifold $M$ as a domain in affine space equipped with a metric which is the Hessian of a cubic polynomial. We prove that the tangent bundle $N=TM$ carries a canonical structure of (affine) special K��hler manifold. This gives an intrinsic description of the $r$-map as the map $M\mapsto N=TM$. On the physics side, this map corresponds to the dimensional reduction of rigid vector multiplets from 5 to 4 space-time dimensions. We generalise this construction to the case when $M$ is any Hessian manifold.

Statins, because of their excellent efficacy and manageable safety profile, represent a key component in the current armamentarium for the treatment of hypercholesterolemia. Nonetheless, myopathy remains a safety concern for this important drug class. Cerivastatin was withdrawn from the market for myotoxicity safety concerns. BMS-423526 [{(3 R ,5 S )-7-[4-(4-fluorophenyl)-6,7-dihydro-2-(1-methylethyl)-5 H -benzo[6,7]cyclohepta[1,2- b ]pyridin-3-yl]-3,5-dihydroxy-heptenoic acid} sodium salt], similar to cerivastatin in potency and lipophilicity, was terminated in early clinical development due to an unacceptable myotoxicity profile. In this report, we describe the guinea pig as a model of statin-induced cholesterol lowering and myotoxicity and show that this model can distinguish statins with unacceptable myotoxicity profiles from statins with acceptable safety profiles. In our guinea pig model, both cerivastatin and BMS-423526 induced myotoxicity at doses near the ED50 for total cholesterol (TC) lowering in plasma. In contrast, wide differences between myotoxic and TC-lowering doses were established for the currently marketed, more hydrophilic statins, pravastatin, rosuvastatin, and atorvastatin. This in vivo model compared favorably to an in vitro model, which used statin inhibition of cholesterol synthesis in rat hepatocytes and L6 myoblasts as surrogates of potential efficacy and toxicity, respectively. Our conclusion is that the guinea pig is a useful preclinical in vivo model for demonstrating whether a statin is likely to have an acceptable therapeutic safety margin.

We survey recent developments which led to the proof of the Benson-Gordon conjecture on K��hler quotients of solvable Lie groups. In addition we prove that the Albanese morphism of a K��hler manifold which is a homotopy torus is a biholomorphic map. The latter result then implies the classification of compact aspherical K��hler manifolds with (virtually) solvable fundamental group up to biholomorphic equivalence. They are all biholomorphic to complex manifolds which are obtained as a quotient of $\bbC^n$ by a discrete group of complex isometries.

We classify flat strict nearly K��hler manifolds with (necessarily) indefinite metric. Any such manifold is locally the product of a flat pseudo-K��hler factor of maximal dimension and a strict flat nearly K��hler manifold of split signature $(2m,2m)$ with $m\ge 3$. Moreover, the geometry of the second factor is encoded in a complex three-form $��\in ��^3 (\mathbb{C}^m)^*$. The first nontrivial example occurs in dimension $4m=12$., 14 pages

A series of inhibitors of mammalian 15-lipoxygenase based on tryptamine and homotryptamine scaffolds is described. Compounds with aryl substituents at C-2 of the indole core of tryptamine and homotryptamine sulfonamides (e.g., 37a-p) proved to be potent inhibitors of the isolated enzyme. Selected compounds also demonstrated desirable inhibition selectivities over isozymes 5- and P-12-LO.

We explore the possibility of baryogenesis without departure from thermal equilibrium. A possible scenario is found, though it contains strong constraints on the size of the $CPT$ violation ($CPTV$) effects and on the role of the $B$ (baryon number) nonconserving interactions which are needed for it., Revtex, 4pages

A series of benzodiazepine-based inhibitors of mitochondrial F 1 F 0 ATP hydrolase were prepared and evaluated for their ability to selectively inhibit the enzyme in the forward direction. Compounds from this series showed excellent potency and selectivity for ATP hydrolase versus ATP synthase, suggesting a potentially beneficial profile useful for the treatment of ischemic heart disease.

A series of benzodiazepine-based inhibitors of mitochondrial F 1 F 0 ATP hydrolase were prepared and evaluated for their ability to selectively inhibit the enzyme in the forward direction. Compounds from this series showed excellent potency and selectivity for ATP hydrolase versus ATP synthase, suggesting a potentially beneficial profile useful for the treatment of ischemic heart disease.

A series of substituted guanidine derivatives were prepared and evaluated as potent and selective inhibitors of mitochondrial F 1 F 0 ATP hydrolase. The initial thiourethane derived lead molecules possessed intriguing in vitro pharmacological profiles, though contained moieties considered non-drug-like. Analogue synthesis efforts led to compounds with maintained potency and superior physical properties. Small molecules in this series which potently and selectivity inhibit ATP hydrolase and not ATP synthase may have utility as cardioprotective agents.

We show that the natural S^1-bundle over a projective special Kaehler manifold carries the geometry of a proper affine hypersphere endowed with a Sasakian structure. The construction generalizes the geometry of the Hopf-fibration $\Sr^{2n+1} \longrightarrow \CP^n$ in the context of projective special Kaehler manifolds. As an application we have that a natural circle bundle over the Kuranishi moduli space of a Calabi-Yau threefold is a Lorentzian proper affine hypersphere.

We prove that any simply connected special Kaehler manifold admits a canonical immersion as a parabolic affine hypersphere. As an application, we associate a parabolic affine hypersphere to any nondegenerate holomorphic function. Also we show that a classical result of Calabi and Pogorelov on parabolic spheres implies Lu's theorem on complete special Kaehler manifolds with a positive definite metric., 5 pages

We have previously demonstrated that both CC(A/T-rich)6GG (CArG) elements A and B of the smooth muscle (SM) alpha-actin promoter are required for smooth muscle cell (SMC)-specific expression and angiotensin II (AII)-induced stimulation. Moreover, results provided evidence that AII responsiveness of SM alpha-actin was at least partially dependent on modulation of serum response factor (SRF) binding to the SM alpha-actin CArGs by the homeodomain containing protein, MHox. The goal of the present study was to investigate whether the degeneracy of the SM alpha-actin CArGs (both contain a Gua or Cyt substitution in their A/T-rich center) and their reduced SRF binding activity as compared with c-fos serum response element (SRE) is important for conferring cell type-specific expression and AII responsiveness. Transient transfection assays using SM alpha-actin reporter gene constructs in which the endogenous SM alpha-actin CArGs were replaced by c-fos SREs demonstrated the following: 1) relaxation of cell-specific expression, 2) a 50% reduction in AII responsiveness, and 3) reduced ability to be transactivated by MHox. In addition, we also showed that the position of the SM alpha-actin CArGs was important in that interchanging them abolished both basal and AII-induced activities. Taken together, these results suggest that the reduced SRF binding activities of the SM alpha-actin CArGs and CArG positional context contribute to SMC-specific expression of SM alpha-actin as well as maximal AII responsiveness.

Motivated by the physical concept of special geometry two mathematical constructions are studied, which relate real hypersurfaces to tube domains and complex Lagrangean cones respectively. Me\-thods are developed for the classification of homogeneous Riemannian hypersurfaces and for the classification of linear transitive reductive algebraic group actions on pseudo Riemannian hypersurfaces. The theory is applied to the case of cubic hypersurfaces, which is the case most relevant to special geometry, obtaining the solution of the two classification problems and the description of the corresponding homogeneous special K\"ahler manifolds.