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982 results on '"Cooper, Timothy"'

205. Hypomethylated Fgf3 is a potential biomarker for early detection of oral cancer in mice treated with the tobacco carcinogen dibenzo[def,p]chrysene

Author

Sun, Yuan-Wan, primary, Chen, Kun-Ming, additional, Imamura Kawasawa, Yuka, additional, Salzberg, Anna C., additional, Cooper, Timothy K., additional, Caruso, Carla, additional, Aliaga, Cesar, additional, Zhu, Junjia, additional, Gowda, Krishne, additional, Amin, Shantu, additional, and El-Bayoumy, Karam, additional

Published
2017
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209. SH3GLB2/endophilin B2 regulates lung homeostasis and recovery from severe influenza A virus infection

Author

Fino, Kristin K., primary, Yang, Linlin, additional, Silveyra, Patricia, additional, Hu, Sanmei, additional, Umstead, Todd M., additional, DiAngelo, Susan, additional, Halstead, E. Scott, additional, Cooper, Timothy K., additional, Abraham, Thomas, additional, Takahashi, Yoshinori, additional, Zhou, Zhixiang, additional, Wang, Hong Gang, additional, and Chroneos, Zissis C., additional

Published
2017
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219. Successful chemoimmunotherapy against hepatocellular cancer in a novel murine model

Author

Li, Guangfu, primary, Liu, Dai, additional, Cooper, Timothy K., additional, Kimchi, Eric T., additional, Qi, Xiaoqiang, additional, Avella, Diego M., additional, Li, Ningfei, additional, Yang, Qing X., additional, Kester, Mark, additional, Rountree, C. Bart, additional, Kaifi, Jussuf T., additional, Cole, David J., additional, Rockey, Don C., additional, Schell, Todd D., additional, and Staveley-O’Carroll, Kevin F., additional

Published
2017
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221. Sorafenib and Quinacrine Target Anti-Apoptotic Protein MCL1: A Poor Prognostic Marker in Anaplastic Thyroid Cancer (ATC)

Author

Abdulghani, Junaid, primary, Gokare, Prashanth, additional, Gallant, Jean-Nicolas, additional, Dicker, David, additional, Whitcomb, Tiffany, additional, Cooper, Timothy, additional, Liao, Jiangang, additional, Derr, Jonathan, additional, Liu, Jing, additional, Goldenberg, David, additional, Finnberg, Niklas K., additional, and El-Deiry, Wafik S., additional

Published
2016
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223. Filoviruses Infect Rhesus Macaque Synoviocytes in Vivoand Primary Human Synoviocytes in Vitro

Author

Cooper, Timothy K., Logue, James, Liu, David X., Perry, Donna L., Hart, Randy J., Hischak, Amanda M.W., Bernbaum, John G., Gerhardt, Dawn M., Rojas, Oscar, Bohannon, J. Kyle, Hagen, Katie R., Johnson, Reed F., Crozier, Ian, Jahrling, Peter B., Hensley, Lisa E., and Bennett, Richard S.

Abstract

The most commonly reported symptom of post–Ebola virus disease syndrome in survivors is arthralgia, yet involvement of the joints in acute or convalescent Ebola virus infection is not well characterized in human patients or animal models. Through immunohistochemistry, we found that the lining synovial intima of the stifle (knee) is a target for acute infection by Ebola virus/Kikwit, Ebola virus/Makona-C05, and Marburg virus/Angola in the rhesus macaque model. Furthermore, histologic analysis, immunohistochemistry, RNAscope in situhybridization, and transmission electron microscopy showed that synoviocytes of the stifle, shoulder, and hip are a target for mouse-adapted Ebola virus/Yambuku-Mayinga infection during acute disease in rhesus macaques. A time course of infection study with Ebola virus/Kikwit found that the large joint synovium became immunopositive beginning on postinfection day 6. In total, the synovium of 28 of 30 rhesus macaques with terminal filovirus disease had evidence of infection (64 of 96 joints examined). On the basis of immunofluorescence, infected cell types included CD68+type A (macrophage-like) synoviocytes and CD44+type B (fibroblast-like) synoviocytes. Cultured primary human fibroblast–like synoviocytes were permissive to infection with Ebola and Marburg viruses in vitro.Because synovial joints include immune privileged sites, these findings are significant for future investigations of filovirus pathogenesis and persistence as well as arthralgias in acute and convalescent filovirus disease.

Published
2020
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224. Housing Conditions Modulate the Severity of Mycoplasma pulmonis Infection in Mice Deficient in Class A Scavenger Receptor

Author

Booth, Jennifer L, Umstead, Todd M, Hu, Sanmei, Dybvig, Kevin F, Cooper, Timothy K, Wilson, Ronald P, and Chroneos, Zissis C

Subjects
Mice, Knockout, Analysis of Variance, Time Factors, Tumor Necrosis Factor-alpha, Blotting, Western, Interleukin-1beta, Scavenger Receptors, Class A, Mouse Models, Housing, Animal, Mycoplasma pulmonis, Mice, Ammonia, Air Pollution, Indoor, Animals, Electrophoresis, Polyacrylamide Gel, Mycoplasma Infections, Chemokines, Chemokine CCL2
Abstract

Mycoplasmosis is a frequent causative microbial agent of community-acquired pneumonia and has been linked to exacerbation of chronic obstructive pulmonary disease. The macrophage class A scavenger receptor (SRA) facilitates the clearance of noxious particles, oxidants, and infectious organisms by alveolar macrophages. We examined wildtype and SRA(-/-) mice, housed in either individually ventilated or static filter-top cages that were cycled with fresh bedding every 14 d, as a model of gene-environment interaction on the outcome of pulmonary Mycoplasma pulmonis infection. Intracage NH3 gas measurements were recorded daily prior to infection. Mice were intranasally infected with 1 × 10(7) cfu M. pulmonis UAB CT and evaluated at 3, 7, and 14 d after inoculation. Wildtype mice cleared 99.5% of pulmonary M. pulmonis by 3 d after infection but remained chronically infected through the study. SRA (-/-) mice were chronically infected with 40-fold higher mycoplasma numbers than were wildtype mice. M. pulmonis caused a chronic mixed inflammatory response that was accompanied with high levels of IL1β, KC, MCP1, and TNFα in SRA(-/-) mice, whereas pulmonary inflammation in WT mice was represented by a monocytosis with elevation of IL1β. Housing had a prominent influence on the severity and persistence of mycoplasmosis in SRA(-/-) mice. SRA(-/-) mice housed in static cages had an improved recovery and significant changes in surfactant proteins SPA and SPD compared with baseline levels. These results indicate that SRA is required to prevent chronic mycoplasma infection of the lung. Furthermore, environmental conditions may exacerbate chronic inflammation in M. pulmonis-infected SRA(-/-) mice.

Published
2014

225. Persistence of Lassa Virus Associated With Severe Systemic Arteritis in Convalescing Guinea Pigs (Cavia porcellus).

Author

Liu, David X, Perry, Donna L, DeWald, Lisa Evans, Cai, Yingyun, Hagen, Katie R, Cooper, Timothy K, Huzella, Louis M, Hart, Randy, Bonilla, Amanda, Bernbaum, John G, Janosko, Krisztina B, Adams, Ricky, Johnson, Reed F, Kuhn, Jens H, Schnell, Matthias J, Crozier, Ian, Jahrling, Peter B, Torre, Juan C de la, and de la Torre, Juan C

Subjects
GUINEA pigs, VIRUSES, ARTERITIS, HEMORRHAGIC fever, TRANSMISSION electron microscopy, IN situ hybridization
Abstract

Lassa fever (LF) survivors develop various clinical manifestations including polyserositis, myalgia, epididymitis, and hearing loss weeks to months after recovery from acute infection. We demonstrate a systemic lymphoplasmacytic and histiocytic arteritis and periarteritis in guinea pigs more than 2 months after recovery from acute Lassa virus (LASV) infection. LASV was detected in the arterial tunica media smooth muscle cells by immunohistochemistry, in situ hybridization, and transmission electron microscopy. Our results suggest that the sequelae of LASV infection may be due to virus persistence resulting in systemic vascular damage. These findings shed light on the pathogenesis of LASV sequelae in convalescent human survivors. [ABSTRACT FROM AUTHOR]

Published
2019
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227. Editorial: Obituary: Susan Drucker-Brown (1936-2023).

Author

Chua, Liana, Cooper, Timothy, and Strathern, Marilyn

Subjects
TRUST
Abstract

This issue of CJA—Technologies and Infrastructures of Trust—is guest edited by Anna Weichselbraun, Shaila Seshia Galvin and Ramah McKay, and features articles by Kate McClellan, Julie Billaud, Cal Biruk, Adela Zhang and Ramah McKay, plus an Afterword by Andrea Ballestero. [ABSTRACT FROM AUTHOR]

Published
2023
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236. The Preschool Confusion Assessment Method for the ICU

Author

Smith, Heidi A. B., primary, Gangopadhyay, Maalobeeka, additional, Goben, Christina M., additional, Jacobowski, Natalie L., additional, Chestnut, Mary Hamilton, additional, Savage, Shane, additional, Rutherford, Michael T., additional, Denton, Danica, additional, Thompson, Jennifer L., additional, Chandrasekhar, Rameela, additional, Acton, Michelle, additional, Newman, Jessica, additional, Noori, Hannah P., additional, Terrell, Michelle K., additional, Williams, Stacey R., additional, Griffith, Katherine, additional, Cooper, Timothy J., additional, Ely, E. Wesley, additional, Fuchs, D. Catherine, additional, and Pandharipande, Pratik P., additional

Published
2016
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242. Mechanisms of oral carcinogenesis induced by dibenzo[a,l]pyrene: an environmental pollutant and a tobacco smoke constituent

Author

Chen, Kun-Ming, Guttenplan, Joseph B., Zhang, Shang-Min, Aliaga, Cesar, Cooper, Timothy K., Sun, Yuan-Wan, DelTondo, Joseph, Kosinska, Wieslawa, Sharma, Arun K., Jiang, Kun, Bruggeman, Richard, Ahn, Kwangmi, Amin, Shantu, and El-Bayoumy, Karam

Subjects
stomatognathic diseases, Mice, Smoke, Mutation, Tobacco, Animals, Female, Mouth Neoplasms, Benzopyrenes, Genes, p53, Immunohistochemistry, Article, Carcinogens, Environmental
Abstract

We previously reported that dibenzo[a,l]pyrene (DB[a,l]P), the most potent known environmental carcinogen among polycyclic aromatic hydrocarbons (PAH) congeners, is carcinogenic in the oral tissues of mice. We have now developed a new mouse model which employs the oral application of the fjord region diol epoxide, (±)-anti-11,12-dihydroxy-13,14-epoxy-11,12,13,14-tetrahydrodibenzo[a,l]pyrene (DB[a,l]PDE), a metabolite of the tobacco smoke constituent DB[a,l]P, and we show its specific induction of oral squamous cell carcinoma (OSCC) in both tongue and other oral tissues. Groups of B6C3F1 mice (20/group) received 6 or 3 nmol of (±)-anti-DB[a,l]PDE administered into the oral cavity; 3 times per week for 38 weeks. Additional groups received the vehicle alone or were left untreated. Mice were sacrificed 42 weeks after the first carcinogen administration. The high dose induced 74 % and 100 % OSCC in the tongue and other oral tissues, respectively; the corresponding values at the lower dose were 45 % and 89 %. Using immunohistochemistry, we showed that DB[a,l]PDE resulted in overexpression of p53 and COX-2 proteins in malignant tissues when compared to normal oral tissues and tongues. Consistent with the carcinogenicity, we demonstrated powerful mutagenicity in cII gene in B6C3F1 (Big Blue) mouse tongue. The mutational profile in lacI reporter gene is similar to those detected in human head and neck cancer, and p53 mutations were observed in mouse oral tumor tissues. Taken together, we conclude that the formation of diol epoxides plays a major role among the mechanisms by which DB[a,l]P exerts its oral mutagenicity and tumorigenicity.

Published
2013

243. Cinema Itself: Cinephobia, Filmic Anxieties, and Ontologies of the Moving Image in Pakistan.

Author

Cooper, Timothy P. A.

Subjects
*ONTOLOGY, *MOTION pictures, *THEORY of knowledge, *ANXIETY
Abstract

Anxieties over the particular ontology and materiality of the film image—rather than moral concerns over the co-mingling of bodies in the built and social space of the cinema—have been addressed by two formative figures in the philosophy of Pakistan as a political and religious idea: Muhammad Iqbal and Syed Abul A'la Maududi. Their arguments provide two divergent examples of the ways in which the permissibility of film in Pakistan has been expressed. This essay is driven by such instances in which the epistemology—and in some cases permissibility—of technological objects is negotiated via their very ontology. [ABSTRACT FROM AUTHOR]

Published
2018
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244. Combined sublethal irradiation and agonist anti-CD40 enhance donor T cell accumulation and control of autochthonous murine pancreatic tumors.

Author

Ward-Kavanagh, Lindsay K., Kokolus, Kathleen M., Cooper, Timothy K., Lukacher, Aron E., and Schell, Todd D.

Subjects
CD40 antigen, T cells, IMMUNOSUPPRESSION, PANCREATIC cancer treatment, CANCER immunotherapy, IRRADIATION
Abstract

Tumor-reactive T lymphocytes can promote the regression of established tumors. However, their efficacy is often limited by immunosuppressive mechanisms that block T cell accumulation or function. ACT provides the opportunity to ameliorate immune suppression prior to transfer of tumor-reactive T cells to improve the therapeutic benefit. We evaluated the combination of lymphodepleting whole body irradiation (WBI) and agonist anti-CD40 (αCD40) antibody on control of established autochthonous murine neuroendocrine pancreatic tumors following the transfer of naïve tumor-specific CD8 T cells. Sublethal WBI had little impact on disease outcome but did promote T cell persistence in the lymphoid organs. Host conditioning with αCD40, an approach known to enhance APC function and T cell expansion, transiently increased donor T cell accumulation in the lymphoid organs and pancreas, but failed to control tumor progression. In contrast, combined WBI and αCD40 prolonged T cell proliferation and dramatically enhanced accumulation of donor T cells in both the lymphoid organs and pancreas. This dual conditioning approach also promoted high levels of inflammation in the pancreas and tumor, induced histological regression of established tumors, and extended the lifespan of treated mice. Prolonged survival was entirely dependent upon adoptive transfer, but only partially dependent upon IFNγ production by donor T cells. Our results identify the novel combination of two clinically relevant host conditioning approaches that synergize to overcome immune suppression and drive strong tumor-specific T cell accumulation within well-established tumors. [ABSTRACT FROM AUTHOR]

Published
2018
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245. Chronic Ovine Studies Demonstrate Low Thromboembolic Risk in the Penn State Infant Ventricular Assist Device

Author

Lukic, Branka, Clark, J. Brian, Izer, Jenelle M., Cooper, Timothy K., Finicle, Heidi A., Cysyk, Johua, Doxtater, Bradly, Yeager, Eric, Reibson, John, Newswanger, Raymond K., Leibich, Patrick, Bletcher, Kirby, and Weiss, William J.

Abstract

Supplemental Digital Content is available in the text.Mechanical circulatory support for children under 6 years of age remains a challenge. This article describes the preclinical status and the results of recent animal testing with the Penn State Infant Left Ventricular Assist Device (VAD). The objectives have been to 1) demonstrate acceptably low thromboembolic risk to support Food and Drug Administration approval, 2) challenge the device by using minimal to no anticoagulation in order to identify any design or manufacturing weaknesses, and 3) improve our understanding of device thrombogenicity in the ovine animal model, using multicomponent measurements of the coagulation system and renal ischemia quantification, in order to better correlate animal results with human results.The Infant VAD was implanted as a left VAD (LVAD) in 18–29 kg lambs. Twelve LVAD and five surgical sham animals were electively terminated after approximately 30 or 60 days. Anticoagulation was by unfractionated heparin targeting thromboelastography R times of 2x normal (n= 6) or 1x normal (n= 6) resulting in negligible heparin activity as measured by anti-Xa assay (<0.1 IU/ml). Platelet inhibitors were not used.There were no clinically evident strokes or evidence of end organ dysfunction in any of the 12 electively terminated LVAD studies. The degree of renal ischemic lesions in device animals was not significantly different than that found in five surgical sham studies, demonstrating minimal device thromboembolism.In summary, these results in a challenging animal test protocol support the conclusion that the Penn State Infant VAD has a low thromboembolic risk and may allow lower levels of anticoagulation.

Published
2019
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246. Histopathologic evaluation of lung and extrapulmonary tissues show sex differences in Klebsiella pneumoniae - infected mice under different exposure conditions

Author

Mikerov, Anatoly N, Cooper, Timothy K, Wang, Guirong, Hu, Sanmei, Umstead, Todd M, Phelps, David S, and Floros, Joanna

Subjects
Original Article
Abstract

It has been shown that female mice with pneumonia have a survival advantage over males, but this is reversed if ozone exposure precedes infection. The purpose of this study was to investigate factors that underlie these observations, by studying histopathologic changes in lung and extrapulmonary (spleen and liver) tissues after ozone or filtered air (FA) exposure followed by pulmonary bacterial infection. Male and female wild type C57BL/6J mice were exposed to ozone or FA, then anesthetized and infected intratracheally with Klebsiella pneumoniae bacteria. Tissues (lung, spleen, and liver) were subjected to histopathologic analysis at 48 h post-infection. We found that after infection, 1) the severity of inflammation was higher, the affected area of the lung was larger, and spleen red pulp myelopoiesis was lower in ozone-exposed mice compared to FA-exposed animals in both sexes; 2) more pronounced extrapulmonary lesions (in liver and spleen) were observed in FA-exposed males compared to FA-exposed females; and 3) excessive lung inflammatory response was detected in ozone-exposed females compared to ozone-exposed males. We concluded that different risk factors contribute to the differential outcome of pneumonia between sexes in the presence or absence of ozone-induced oxidative stress. In specific, the excessive lung inflammation and higher risk for extrapulmonary lesions in ozone-exposed infected females and in FA-exposed infected males appear to play, respectively, a dominant role in the previously observed respective survival outcomes.

Published
2011

248. Reviews.

Author

Andía, Juan Javier Rivera, Singh, Mansheetal, Handelman, Don, Stadler, Nurit, Cooper, Timothy P. A., van den Brandt, Nella, Kuyk, Elza, Tremlett, Paul-François, Wijnia, Lieke, Aellah, Gemma, Oustinova-Stjepanovic, Galina, Rivadossi, Silvia, Lourenço, Inês, and Torri, Davide

Published
2022
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