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1,891 results on '"Cooper, Mark E"'

208. Effect of Linagliptin vs Placebo on Major Cardiovascular Events in Adults With Type 2 Diabetes and High Cardiovascular and Renal Risk

Author

Rosenstock Julio, Perkovic Vlado, Johansen Odd Erik, Cooper Mark E., Kahn Steven E., Kollaborációs szervezet: CARMELINA Investigators, Mihály Emese, Keltai Katalin, Baló Tímea, Somogyi Anikó, Nagy Géza, Tabák Ádám, Ferencz Viktória, Domján Beatrix Annamária, Tänczer Tímea, Bajnok László Zoltán, Szujó Szabina, Nemes Orsolya, Mezősi Emese, Bódis Beáta, Márton Zsolt, Takács Róbert, Ábrahám György, and Fehértemplomi Katalin

Subjects
03.02. Klinikai orvostan
Abstract

IMPORTANCE Type 2 diabetes is associated with increased cardiovascular (CV) risk. Prior trials have demonstrated CV safety of 3 dipeptidyl peptidase 4 (DPP-4) inhibitors but have included limited numbers of patients with high CV risk and chronic kidney disease.

Published
2019

212. Characterization of binding sites for amylin, calcitonin, and CGRP in primate kidney

Author

Chai, Siew Yeen, Christopoulos, George, Cooper, Mark E., and Sexton, Patrick M.

Subjects
Binding sites (Biochemistry) -- Research, Calcitonin -- Physiological aspects, Kra -- Physiological aspects, Peptides -- Physiological aspects, G proteins -- Physiological aspects, Biological sciences
Abstract

Investigation of receptor distributions for 125I-labeled amylin, 125I-labeled calcitonin and 125I-labeled calcitonin generated peptide (CGRP) in Macaca fascicularis kidney by in vitro radiography showed distinct patterns of binding for each peptide. 125I-rat amylin bound mostly to the cortex, being associated with the distal tubule, including apparent binding to the juxtaglomerular mechanism. 125I-rat CGRP-alpha showed low- to moderate-density binding to the inner medulla/papilla with high-density binding over small-, medium- and large-caliber arteries.

Published
1998

218. Amylin stimulates proximal tubular sodium transport and cell proliferation in the rat kidney

Author

Harris, Peter J., Cooper, Mark E., Hiranyachattada, Siriphun, Berka, Jennifer L., Kelly, Darren J., Nobes, Michael, and Wookey, Peter J.

Subjects
Pancreas -- Secretions, Renal tubular transport -- Physiological aspects, Kidneys -- Physiological aspects, Rats as laboratory animals -- Physiological aspects, Biological sciences
Abstract

The binding sites of amylin in the proximal tubules of the kidney were analyzed by 125I-labeled amylin infusions in anesthetized rats to determine the role of the 37-amino acid peptide in tubular sodium transport. Radiolabeled amylin infusion stimulated fluid absorption in the renal proximal tubules of Nembutal-anesthetized Sprague-Dawley rats. Furthermore, amylin promoted the renal tubular transport of sodium and water reabsorption and renal cell proliferation in rats.

Published
1997

231. Limitations of cognitive status exams: a case based discussion

Author

Hawkins, Keith A. and Cooper, Mark E.

Subjects
Psychiatric disability evaluation -- Research, Neuropsychological tests -- Research, Clinical psychology -- Methods, Psychology and mental health
Abstract

Despite their extensive use in psychiatric and medical settings, brief mental status examinations have significant limitations that are easily overlooked in the pressure-cooker environments within which they are commonly used. Although undoubtedly of value as quick screening devices, the sheer brevity of these instruments all but guarantees limited validity. Brief examinations perform best with grossly impaired cases, alerting clinicians to the fact that something is badly amiss in patients who are significantly confused, disoriented, aphasic, or otherwise severely impaired. Very poor scores are accordingly frequently useful. Moderate or even perfect scores, however, will frequently be misleading, because patients with compromised brains often obtain them (Nelson et al. 1986). One such case follows.

Published
1996

232. Amylin binding in rat renal cortex, stimulation of adenylyl cyclase, and activation of plasma renin

Author

Wookey, Peter J., Tikellis, Christos, Du, He-Cheng, Qin, Hai-Feng, Sexton, Patrick M., and Cooper, Mark E.

Subjects
Amylinamide -- Physiological aspects, Renin -- Physiological aspects, Renal hypertension -- Physiological aspects, Biological sciences
Abstract

Amylin is a 37-amino acid peptide secreted by pancreatic beta-cells to regulate carbohydrate metabolism. It has been suggested that amylin may also be involved in hypertension and insulin resistance. Herein, specific high-affinity binding sites for 125I-labeled amylin were identified and characterized by competitive inhibition with amylin analogues. The results showed that amylin is an activator of plasma renin, which has an important role in renal physiology. It is suggested that amylin is associated with hyperamylinemia and the development of hypertension.

Published
1996

248. Acute renal hemodynamic effects of ACE inhibition in diabetic hyperfiltration: role of kinins

Author

Komers, Radko and Cooper, Mark E.

Subjects
ACE inhibitors -- Research, Kinins -- Analysis, Diabetes -- Research, Biological sciences
Abstract

The kinins have a major role in the renal effects of angiotensin converting enzyme (ACE) inhibitors in diabetic hyperfiltration. There are contrasting effects of renal hemodynamic responses to acute ACEI in diabetic rats in comparison to control rats. This is due to the reason that ACE inhibitors reduce angiotensin II levels and also prevent kinin degradation. However, the different aspects of ACEI and angiotensin type I receptor antagonism on diabetic nephropathy needs further examination.

Published
1995

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