784 results on '"Chiarugi, P"'
Search Results
202. Detection of Released CO2 by Radioactive Lactate
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Tania Fiaschi and Paola Chiarugi
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Biology (General) ,QH301-705.5 - Abstract
This method allows to evaluate the degradation of lactate during cellular respiration. During this metabolic process, carbon atoms of lactate can be transformed in carbon dioxide. For this purpose, the radioactive lactate is added to the cells and the amount of radioactive carbon dioxide liberated is monitored. The radioactive carbon dioxide generated during cellular respiration is released into the culture medium and it is further converted into gas through the addition of sulfuric acid to culture media. A piece of Whatman paper wet with phenyl-ethylamine-methanol is placed inside the petri dish to trap radioactive carbon dioxide whose production is then evaluated by scintillator counting.
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- 2013
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203. Analysis of the Incorporation of Carbon Atoms from Radioactive Lactate into Proteins
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Tania Fiaschi and Paola Chiarugi
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Biology (General) ,QH301-705.5 - Abstract
This method allows to analyze if the carbon atoms of lactate are embedded into proteins. Indeed, mammalian cells express the transporter of monocarboxylic acids (called MCT1) that allows the entry of lactate into the cell. To this end, cells are incubated for 24 h with the culture medium containing lactate uniformly labeled with carbon 14 and then, lactate inside the cell is evaluated by counting the radioactivity by a scintillator.
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- 2013
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204. Attività normativa: pubblicate le norme UNI per geotermia, in corso il progetto di norma per i pozzi
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Stefano Chiarugi
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Geology ,QE1-996.5 - Published
- 2013
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205. Can the American College of Surgeons NSQIP Surgical Risk Calculator Accurately Predict Adverse Postoperative Outcomes in Emergency Abdominal Surgery? An Italian Multicenter Analysis
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Scotton, Giovanni, La Greca, Antonio, Lirusso, Chiara, Mariani, Diego, Zago, Mauro, Chiarugi, Massimo, Tartaglia, Dario, de Manzini, Nicolò, Biloslavo, Alan, Penazzi, Riccardo, Cosola, Davide, di Grezia, Marta, Crestale, Sara, Lo Bianco, Giulia, and Bonfanti, Giulia
- Abstract
The American College of Surgeons NSQIP Surgical Risk Calculator was not validated in emergency surgery outside the US. External validation on 2,749 emergency procedures was performed at 6 Italian institutions. The analysis showed that the calculator is a reliable predictor of adverse postoperative outcomes, particularly mortality.
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- 2023
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206. Spread and feasibility of non-operative management (NOM) of traumatic splenic injuries in adults: a national survey
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Visconti, Diego, Parini, Dario, Mariani, Diego, Biloslavo, Alan, Bellio, Gabriele, Ceolin, Martina, Cozza, Valerio, Musetti, Serena, Pivetta, Emanuele, Kurihara, Hayato, Zago, Mauro, Santarelli, Mauro, and Chiarugi, Massimo
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In hemodynamically stable adults sustaining a splenic trauma, non-operative management (NOM) represents the standard approach even in high-severity injuries. However, knowledge, structural, and logistic limitations still reduce its wider diffusion. This study aims to identify such issues to promote the safe and effective management of these injuries.
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- 2023
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207. Insight into molecular and functional properties of NMNAT3 reveals new hints of NAD homeostasis within human mitochondria.
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Roberta Felici, Andrea Lapucci, Matteo Ramazzotti, and Alberto Chiarugi
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Medicine ,Science - Abstract
Among the enzymes involved in NAD homeostasis, nicotinamide mononucleotide adenylyltransferases (NMNAT1-3) are central to intracellular NAD formation. Although NMNAT3 is postulated to be a mitochondrial enzyme contributing to NAD-dependent organelle functioning, information on endogenous proteins is lacking. We report that in human cells a single gene nmnat3 localized on chromosome 3 codes for two mRNA splice variants NMNATv1 and FKSG76, whereas the previously reported NMNAT3v2 transcript is not present. However, NMNAT3v1 and FKSG76 proteins are not detectable, consistent with the finding that an upstream ORF in their mRNAs negatively regulates translation. NMNAT3v1 transfection demonstrates that the protein is cytosolic and inactive, whereas FKSG76 is mitochondrial but operates NAD cleavage rather than synthesis. In keeping with the lack of NMNAT3, we show that extracellular NAD, but not its metabolic precursors, sustains mitochondrial NAD pool in an ATP-independent manner. Data of the present study modify the scenario of the origin of mitochondrial NAD by showing that, in human cells, NMNAT3 is absent in mitochondria, and, akin to plants and yeast, cytosolic NAD maintains the mitochondrial NAD pool.
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- 2013
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208. Correction: Insight into Molecular and Functional Properties of NMNAT3 Reveals New Hints of NAD Homeostasis within Human Mitochondria.
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Roberta Felici, Andrea Lapucci, Matteo Ramazzotti, and Alberto Chiarugi
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Medicine ,Science - Published
- 2013
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209. Laparoscopic Cholecystectomy in Acute Cholecystitis: Refining the Best Surgical Timing Through Network Meta-Analysis of Randomized Trials
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Coccolini, Federico, Solaini, Leonardo, Binda, Cecilia, Catena, Fausto, Chiarugi, Massimo, Fabbri, Carlo, Ercolani, Giorgio, and Cucchetti, Alessandro
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- 2022
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210. Protective Measures From Solar Ultraviolet Radiation for Beach Lifeguards in Tuscany (Italy): Shade and Clothing Strategies
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Grifoni, Daniele, Betti, Giulio, Bogi, Andrea, Bramanti, Lucia, Chiarugi, Alessandra, Gozzini, Bernardo, Morabito, Marco, Picciolo, Francesco, Sabatini, Francesco, and Miligi, Lucia
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The exposure to solar ultraviolet radiation is a significant risk factor generally underestimated by outdoor workers and employers. Several studies have pointed out that occupational solar exposure increased eye and skin diseases with a considerable impact on the lives and productivity of affected workers.
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- 2022
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211. Perforazione di sonde e pozzi per impianti a pompe di calore
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Stefano Chiarugi
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Geology ,QE1-996.5 - Published
- 2012
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212. Diabetes Management Using Modern Information and Communication Technologies and New Care Models
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Spanakis, Emmanouil G, Chiarugi, Franco, Kouroubali, Angelina, Spat, Stephan, Beck, Peter, Asanin, Stefan, Rosengren, Peter, Gergely, Tamas, and Thestrup, Jesper
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Computer applications to medicine. Medical informatics ,R858-859.7 ,Medical technology ,R855-855.5 - Abstract
BackgroundDiabetes, a metabolic disorder, has reached epidemic proportions in developed countries. The disease has two main forms: type 1 and type 2. Disease management entails administration of insulin in combination with careful blood glucose monitoring (type 1) or involves the adjustment of diet and exercise level, the use of oral anti-diabetic drugs, and insulin administration to control blood sugar (type 2). ObjectiveState-of-the-art technologies have the potential to assist healthcare professionals, patients, and informal carers to better manage diabetes insulin therapy, help patients understand their disease, support self-management, and provide a safe environment by monitoring adverse and potentially life-threatening situations with appropriate crisis management. MethodsNew care models incorporating advanced information and communication technologies have the potential to provide service platforms able to improve health care, personalization, inclusion, and empowerment of the patient, and to support diverse user preferences and needs in different countries. The REACTION project proposes to create a service-oriented architectural platform based on numerous individual services and implementing novel care models that can be deployed in different settings to perform patient monitoring, distributed decision support, health care workflow management, and clinical feedback provision. ResultsThis paper presents the work performed in the context of the REACTION project focusing on the development of a health care service platform able to support diabetes management in different healthcare regimes, through clinical applications, such as monitoring of vital signs, feedback provision to the point of care, integrative risk assessment, and event and alarm handling. While moving towards the full implementation of the platform, three major areas of research and development have been identified and consequently approached: the first one is related to the glucose sensor technology and wearability, the second is related to the platform architecture, and the third to the implementation of the end-user services. The Glucose Management System, already developed within the REACTION project, is able to monitor a range of parameters from various sources including glucose levels, nutritional intakes, administered drugs, and patient’s insulin sensitivity, offering decision support for insulin dosing to professional caregivers on a mobile tablet platform that fulfills the need of the users and supports medical workflow procedures in compliance with the Medical Device Directive requirements. ConclusionsGood control of diabetes, as well as increased emphasis on control of lifestyle factors, may reduce the risk profile of most complications and contribute to health improvement. The REACTION project aims to respond to these challenges by providing integrated, professional, management, and therapy services to diabetic patients in different health care regimes across Europe in an interoperable communication platform.
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- 2012
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213. Si costituisce la FEDERAZIONE fra AIF, ANIPA, ANISIG, IATT
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Stefano Chiarugi
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Geology ,QE1-996.5 - Published
- 2012
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214. Globular adiponectin activates motility and regenerative traits of muscle satellite cells.
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Tania Fiaschi, Elisa Giannoni, Maria Letizia Taddei, and Paola Chiarugi
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Medicine ,Science - Abstract
Regeneration of adult injured skeletal muscle is due to activation of satellite cells, a population of stem cells resident beneath the basal lamina. Thus, information on soluble factors affecting satellite cell activation, as well as migration towards injury and fusion into new myofibers are essential. Here, we show that globular adiponectin (gAd), positively affects several features of muscle satellite cells. gAd activates satellite cells to exit quiescence and increases their recruitment towards myotubes. gAd elicits in satellite cells a specific motility program, involving activation of the small GTPase Rac1, as well as expression of Snail and Twist transcription factors driving a proteolytic motility, useful to reach the site of injury. We show that satellite cells produce autocrine full length adiponectin (fAd), which is converted to gAd by activated macrophages. In turns, gAd concurs to attract to the site of injury both satellite cells and macrophages and induces myogenesis in muscle satellite cells. Thus, these findings add a further role for gAd in skeletal muscle, including the hormone among factors participating in muscle regeneration.
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- 2012
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215. Oxidative Stress, Tumor Microenvironment, and Metabolic Reprogramming: A Diabolic Liaison
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Tania Fiaschi and Paola Chiarugi
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Cytology ,QH573-671 - Abstract
Conversely to normal cells, where deregulated oxidative stress drives the activation of death pathways, malignant cells exploit oxidative milieu for its advantage. Cancer cells are located in a very complex microenvironment together with stromal components that participate to enhance oxidative stress to promote tumor progression. Indeed, convincing experimental and clinical evidence underline the key role of oxidative stress in several tumor aspects thus affecting several characteristics of cancer cells. Oxidants influence the DNA mutational potential, intracellular signaling pathways controlling cell proliferation and survival and cell motility and invasiveness as well as control the reactivity of stromal components that is fundamental for cancer development and dissemination, inflammation, tissue repair, and de novo angiogenesis. This paper is focused on the role of oxidant species in the acquisition of two mandatory features for aggressive neoplastic cells, recently defined by Hanahan and Weinberg as new “hallmarks of cancer”: tumor microenvironment and metabolic reprogramming of cancer cells.
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- 2012
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216. 1B/(-)IRE DMT1 expression during brain ischemia contributes to cell death mediated by NF-κB/RelA acetylation at Lys310.
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Rosaria Ingrassia, Annamaria Lanzillotta, Ilenia Sarnico, Marina Benarese, Francesco Blasi, Laura Borgese, Fabjola Bilo, Laura Depero, Alberto Chiarugi, Pier Franco Spano, and Marina Pizzi
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Medicine ,Science - Abstract
The molecular mechanisms responsible for increasing iron and neurodegeneration in brain ischemia are an interesting area of research which could open new therapeutic approaches. Previous evidence has shown that activation of nuclear factor kappa B (NF-κB) through RelA acetylation on Lys310 is the prerequisite for p50/RelA-mediated apoptosis in cellular and animal models of brain ischemia. We hypothesized that the increase of iron through a NF-κB-regulated 1B isoform of the divalent metal transporter-1 (1B/DMT1) might contribute to post-ischemic neuronal damage. Both in mice subjected to transient middle cerebral artery occlusion (MCAO) and in neuronally differentiated SK-N-SH cells exposed to oxygen-glucose-deprivation (OGD), 1A/DMT1 was only barely expressed while the 1B/DMT1 without iron-response-element (-IRE) protein and mRNA were early up-regulated. Either OGD or over-expression of 1B/(-)IRE DMT1 isoform significantly increased iron uptake, as detected by total reflection X-ray fluorescence, and iron-dependent cell death. Iron chelation by deferoxamine treatment or (-)IRE DMT1 RNA silencing displayed significant neuroprotection against OGD which concomitantly decreased intracellular iron levels. We found evidence that 1B/(-)IRE DMT1 was a target gene for RelA activation and acetylation on Lys310 residue during ischemia. Chromatin immunoprecipitation analysis of the 1B/DMT1 promoter showed there was increased interaction with RelA and acetylation of H3 histone during OGD exposure of cortical neurons. Over-expression of wild-type RelA increased 1B/DMT1 promoter-luciferase activity, the (-)IRE DMT1 protein, as well as neuronal death. Expression of the acetylation-resistant RelA-K310R construct, which carried a mutation from lysine 310 to arginine, but not the acetyl-mimic mutant RelA-K310Q, down-regulated the 1B/DMT1 promoter, consequently offering neuroprotection. Our data showed that 1B/(-)IRE DMT1 expression and intracellular iron influx are early downstream responses to NF-κB/RelA activation and acetylation during brain ischemia and contribute to the pathogenesis of stroke-induced neuronal damage.
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- 2012
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217. Time-dependent stabilization of hypoxia inducible factor-1α by different intracellular sources of reactive oxygen species.
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Maura Calvani, Giuseppina Comito, Elisa Giannoni, and Paola Chiarugi
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Medicine ,Science - Abstract
Intratumoral hypoxia is a major obstacle in the development of effective cancer chemotherapy, decreasing the efficacy of anti-neoplastic drugs in several solid tumours. The hypoxic environment, through its master regulator hypoxia inducible factor-1 (HIF-1), is able to maintain an anti-apoptotic potential through activation of critical genes associated with drug resistance. Besides affecting metabolism and motility of tumour cells, hypoxia also paradoxically increases production of reactive oxygen species (ROS), which contribute to stabilize HIF-1 through a redox-mediated inhibition of its proteolysis. Here we reported that 1% O(2) hypoxia increases the resistance of human metastatic melanoma cells to conventional chemotherapy with etoposide, and that the increase in chemoresistance strongly depends on ROS delivery due to hypoxia. We reported a biphasic redox-dependent role of HIF-1, involving mitochondrial complex III and NADPH oxidase as oxidants sources, synergising in enhancing survival to chemotherapy. The feed-forward loop engaged by hypoxia involves first an HIF-1-dependent vascular endothelial growth factor-A (VEGF-A) autocrine production and, in the later phase, activation of NADPH oxidase from VEGF/VEGFR2 interaction, finally leading to a further redox-dependent long lasting stabilization of HIF-1. We therefore identified a redox-dependent circuitry linking hypoxia-driven ROS to VEGF-A secretion and to enhanced melanoma cell survival to etoposide chemotherapy.
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- 2012
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218. Mitochondrial oxidative metabolism contributes to maintain a cancer stem cell phenotype in cholangiocarcinoma
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Raggi, C., Taddei, M.l., Sacco, E., Navari, N., Correnti, M., Piombanti, B., Pastore, M., Iorio, J., Lori, G., Peano, C., Cibella, J., Lewinska, M., Andersen, J.b., Di Maira, G., Ramazzotti, M., Orlandi, Ivan, Chiarugi, P., Marra, F., Raggi, C., Taddei, M.l., Sacco, E., Navari, N., Correnti, M., Piombanti, B., Pastore, M., Iorio, J., Lori, G., Peano, C., Cibella, J., Lewinska, M., Andersen, J.b., Di Maira, G., Ramazzotti, M., Orlandi, Ivan, Chiarugi, P., and Marra, F.
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- 2020
219. Oxidation and tyrosine phosphorylation: synergistic or antagonistic cues in protein tyrosine phosphatases
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Chiarugi, P., Taddei, M. L., and Ramponi, G.
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- 2005
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220. LMW-PTP is a positive regulator of tumor onset and growth
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Chiarugi, Paola, Taddei, Maria Letizia, Schiavone, Nicola, Papucci, Laura, Giannoni, Elisa, Fiaschi, Tania, Capaccioli, Sergio, Raugei, Giovanni, and Ramponi, Giampietro
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- 2004
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221. Down-regulation of platelet-derived growth factor receptor signaling during myogenesis
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Fiaschi, T., Chiarugi, P., Buricchi, F., Giannoni, E., Taddei, M. L., Magnelli, L., Cozzi, G., Raugei, G., and Ramponi, G.
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- 2003
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222. ‘Reverse Warburg’ phenotype and PK-M2: regulation of pentose phoshate pathway and implications for chemoresistance: SW06.W30–13
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Marini, A., Taddei, M. L., Cavallini, L., Farini, V., Stinziani, S., Paoli, P., Pintus, G., and Chiarugi, P.
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- 2013
223. Cancer associated fibroblasts and M2 polarized macrophages synergize during prostate carcinoma progression: SW04.S17–8
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Comito, G., Giannoni, E., Segura, C. P., Barcellos-de-Souza, P., Raspollini, M. R., Baroni, G., Lanciotti, M., Serni, S., and Chiarugi, P.
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- 2013
224. Role of senescent stroma in prostate cancer progression: SW03.S13–71
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Taddei, M. L., Comito, G., Cavallini, L., Giannoni, E., and Chiarugi, P.
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- 2013
225. Brn-3a, a neuronal transcription factor of the POU gene family: Indications for its involvement in cancer and angiogenesis
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Chiarugi, Vincenzo, Del Rosso, Mario, and Magnelli, Lucia
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- 2002
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226. Low molecular weight protein tyrosine phosphatases: small, but smart
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Raugei, G., Ramponi, G., and Chiarugi, P.
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- 2002
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227. Angiogenesis and the unique nature of tumor matrix
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Chiarugi, Vincenzo, Ruggiero, Marco, and Magnelli, Lucia
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- 2002
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228. Apoptosis: Molecular regulation of cell death and hematologic malignancies
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Chiarugi, Vincenzo, Cinelli, Marina, Magnelli, Lucia, and Sbarba, Persio Dello
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- 2002
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229. Elective surgery system strengthening: development, measurement, and validation of the surgical preparedness index across 1632 hospitals in 119 countries
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Glasbey, James C, Abbott, Tom EF, Ademuyiwa, Adesoji, Adisa, Adewale, AlAmeer, Ehab, Alshryda, Sattar, Arnaud, Alexis P, Bankhead-Kendall, Brittany, Abou Chaar, M K, Chaudhry, Daoud, Costas-Chavarri, Ainhoa, Cunha, Miguel F, Davies, Justine I, Desai, Anant, Elhadi, Muhammed, Fiore, Marco, Fitzgerald, James Edward, Fourtounas, Maria, Fowler, Alex James, Futaba, Kay, Gallo, Gaetano, Ghosh, Dhruva, Gujjuri, Rohan R, Hamilton, Rebecca, Haque, Parvez, Harrison, Ewen M, Hutchinson, Peter, Hyman, Gabriella, Isik, Arda, Jayarajah, Umesh, Kaafarani, Haytham MA, Kadir, Bryar, Lawani, Ismail, Lederhuber, Hans, Li, Elizabeth, Löffler, Markus W, Lorena, Maria Aguilera, Mann, Harvinder, Martin, Janet, Mazingi, Dennis, McClain, Craig D, McLean, Kenneth A, Meara, John G, Ramos-De La Medina, Antonio, Mengesha, Mengistu, Minaya, Ana, Modolo, Maria Marta, Moore, Rachel, Morton, Dion, Nepogodiev, Dmitri, Ntirenganya, Faustin, Pata, Francesco, Pearse, Rupert, Picciochi, Maria, Pinkney, Thomas, Pockney, Peter, van Ramshorst, Gabrielle H, Richards, Toby, Roslani, April Camilla, Satoi, Sohei, Sayyed, Raza, Shaw, Richard, Simões, Joana FF, Smart, Neil, Sullivan, Richard, Sund, Malin, Sundar, Sudha, Tabiri, Stephen, Taylor, Elliott H, Venn, Mary L, Wickramasinghe, Dakshitha, Wright, Naomi, Yip, Sebastian Bernardo Shu, Bhangu, Aneel, Omar, Omar, Harrison, Ewen, Bhangu, Aneel A, Siaw-Acheampong, Kwabena, Benson, Ruth A, Bywater, Edward, Dawson, Brett E, Evans, Jonathan P, Heritage, Emily, Jones, Conor S, Kamarajah, Sivesh K, Khatri, Chetan, Khaw, Rachel A, Keatley, James M, Knight, Andrew, Lawday, Samuel, Mann, Harvinder S, Marson, Ella J, Mckay, Siobhan C, Mills, Emily C, Pellino, Gianluca, Tiwari, Abhinav, Trout, Isobel M, Wilkin, Richard JW, Abukhalaf, Sadi, Adamina, Michel, Ademuyiwa, Adesoji O, Agarwal, Arnav, Akkulak, Murat, Alameer, Ehab, Alderson, Derek, Alakaloko, Felix, Albertsmeier, Markus, Alser, Osaid, Alshaar, Muhammad, Augestad, Knut Magne, Ayasra, Faris, Azevedo, José, Bankhead-Kendall, Brittany K, Barlow, Emma, Beard, David, Blanco-Colino, Ruth, Brar, Amanpreet, Minaya-Bravo, Ana, Breen, Kerry A, Bretherton, Chris, Buarque, Igor Lima, Burke, Joshua, Caruana, Edward J, Chaar, Mohammad, Chakrabortee, Sohini, Christensen, Peter, Cox, Daniel, Cukier, Moises, Davidson, Giana H, Di Saverio, Salomone, Drake, Thomas M, Edwards, John G, Emile, Sameh, Farik, Shebani, Ford, Samuel, Garmanova, Tatiana, Gomes, Gustavo Mendonça Ataíde, Grecinos, Gustavo, Griffiths, Ewen A, Gruendl, Magdalena, Halkias, Constantine, Hisham, Intisar, Hutchinson, Peter J, Hwang, Shelley, Jenkinson, Michael D, Jonker, Pascal, Keller, Debby, Kolias, Angelos, Kruijff, Schelto, Leventoglu, Sezai, Litvin, Andrey, Loehrer, Andrew, Modolo, Maria Marta, Major, Piotr, Mashbari, Hassan N, Metallidis, Symeon, Mohan, Helen M, Moszkowicz, David, Moug, Susan, Ng-Kamstra, Joshua S, Maimbo, Mayaba, Negoi, Ionut, Niquen, Milagros, Olivos, Maricarmen, Oussama, Kacimi, Outani, Oumaima, Parreno-Sacdalanm, Marie Dione, Rivera, Carlos Jose Perez, Pinkney, Thomas D, Plas, Willemijn van der, Qureshi, Ahmad, Radenkovic, Dejan, Ramos-De La Medina, Antonio, Revell, Elliot J, Roberts, Keith, Roslani, April C, Rutegård, Martin, Segura-Sampedro, Juan José, Santos, Irène, Schache, Andrew, Schnitzbauer, Andreas A, Seyi-Olajide, Justina O, Sharma, Neil, Shaw, Catherine A, Shu, Sebastian, Soreide, Kjetil, Spinelli, Antonino, Stewart, Grant D, Townend, Philip, Tsoulfas, Georgios, Vidya, Raghavan, Vimalachandran, Dale, Warren, Oliver J, Wedderburn, Duane, EuroSurg, NA, European Society of Coloproctology (ESCP), NA, Global Initiative for Children's Surgery, NA, GlobalSurg, NA, GlobalPaedSurg, NA, ItSURG, NA, PTSurg, NA, SpainSurg, NA, Italian Society of Colorectal Surgery, NA, Association of Surgeons in Training, NA, Irish Surgical Research Collaborative (ISRC), NA, Transatlantic Australasian Retroperitoneal Sarcoma Working, NA, Italian Society of Surgical Oncology, NA, Booth, Lesley, Barker, Margaret, Barker, Neil, Cooke, Shirley, Doré, Suzanne, Horwood, Nigel, Runigamugabo, Emmy, Weir, Carrie Tierney, Bahrami-Hessari, Mike, Riaz, Asad, Shah, Jaffer, Safi, Mohammed, Thereska, Dariel, Dajti, Irida, Cheddadi, Riadh, Tidjane, Anisse, Quinteros, Carlos A, khelfaoui, Ahmed, Salem, Khalifa M, Riffi, Omar, Kacimi, Salah Eddine O, Loudjedi, Salim, Damerdji, Tidjani, Pantoja Pachajoa, Diana A, Palacios Huatuco, René M, Alvarez, Fernando A, Doniquian, Alejandro M, Abeldaño Zuñiga, Roberto A, Schlottmann, Francisco, Cobos, Carlos M, Gigena, Cecilia, Forneris, Agustin Albani, Duro, Agustin, García-Mansilla, Agustín M, Busnelli, Virginia Cano, Poggi, Catalina, Mercado, Pedro L, González, Marcos, Castro Lalin, Agustina F, Mayer, Horacio F, Brandariz, Rodrigo, Slullitel, Pablo A, Boudou, Rocio, Lobos, Pablo A, Uffelmann, María C, Petersen, Maria L, Luzzi, Emilia, Padilla Lichtenberger, Fernando L, Crespi Amor, María S, Zarratea, Celeste S, Esteves, Tomas A, Gemelli, Nicolas A, Tirapegui, Sebastián, Liyo, Juan, Scherñuk, Jordán, Boccalatte, Luis A, Balmaceda, Ruben D, D'Addino, Jose L, Caubet, María M, Calderón Arancibia, José A, Chwat, Carina, Morris, Brian, Avellaneda, Nicolas, Pedraza Salazar, Ivana I, Eskinazi, Diego G, Vargas, Lara, Muriel, María E, Lucchini, Sergio M, Gosselink, Martijn P, Davis, Amelia L, Barker, John C, Qin, Kirby R, Proud, David M, Cox, Daniel RA, Goh, Su Kah, Liu, David S, Wu, Damien M, Merrett, Neil D, Badiani, Sarit S, Sengupta, Shomik, Jain, Anshini, Steen, Christopher J, Wong, Enoch, Ip, Christopher CK, Leaning, Matthew G, McCartney, Conor B, Gananadha, Sivakumar, Yeap, Evie FW, Stevens, Sean G, Vu, Anh N, Martin, Sarah A, Stanley, Guy H M, Watson, David I, Townend, Philip J, Young, Thomas K, Cox, Georgia T, Dawson, Amanda C, Laura, Sharon E, Lun, Elizabeth W Y, Liang, Ina X, O'Neill, Christine J, Lott, Natalie J, Chuan, Alwin, Saravanan, SK, Gundara, Justin, Ong, Bee Shan, Nataraja, Ramesh M, Pacilli, Maurizio, Foley, Daniel M, Ooi, Geraldine J, Traeger, Luke, MacDermid, Ewan, Daruwalla, Jurstine, Hodgson, Russell, Heriot, Alexander G, Mulligan, Christopher S, Blefari, Nicholas D A, Purcell, Shaun S, Frankel, Adam J, Guerra, Glen R, Tefay, Joan S, Liang, Rhea W Y, Kroon, Hidde M, Farfus, Anthony W, Warren, Leigh R, Roy, Jennifer M, Whitfield, Robert J, Moller, Cea-Cea B, Davis, Sean S, Sammour, Tarik, Lam, Yick Ho, Kour, Kevin, Gan, Siang Wei, Coventry, Brendon J, Dawson, Joseph A, Batstone, Martin D, King, Sebastian K, Scott, Nathan J, Foo, Jonathan W, Shepherd, Talia, Page, Richard S, Choong, Peter F, Badgery, Henry E, Chong, Lynn, Taylor, Lillian, Hii, Michael W, Wright, Gavin M, Kong, Joseph CH, Watson, Matthew M, Bock, Jacob, Lidder, Surjit S, Elias, Patrick, Kanavathy, Sathisvaran, Koh, Cherry E, Chennakesavan, Srinivas Kondalsamy, Panuganti, Vishwakar, Latif, Haider, Yeung, Justin MC, Besson, Alex J, Tse, Eunice Q Y, Pitcher, Meron E, Taylor, Danielle L, Nahm, Christopher B, Lim, Alicia, Tree, Kevin, Aigner, Felix, Dawoud, Christopher, Foessleitner, Philipp, Zimmermann, Matthias, Wiedemann, Dominik, Findl, Oliver, Messner, Franka, Bauer, Marlies, Nägele, Felix, Kronberger, Irmgard E, Öfner, Dietmar, Härter, Bettina, Bicz, Nina Ru B, Zwittag, Paul M, Poier, Nikolaus, Navarro, Francisco Ruiz, Zebuhr, Yorck A, Köglberger, Paul, Wiesinger, Clemens G, Mathew, Erwin, Trivik-Barrientos, Felipe, Königsrainer, Ingmar, Djedovic, Gabriel, Cohnert, Tina U, Lumenta, David B, Singer, Georg, Leithner, Andreas, Kamolz, Lars-Peter, Andrianakis, Alexandros, Puchwein, Paul, Mikalauskas, Saulius, Kirchweger, Patrick, Függer, Reinhold, Mittermair, Christof, Russe, Elisabeth, Paal, Peter, Grünbart, Martin, de Cillia, Michael, Weiss, Helmut G, Steiner, Florian, Binder, Alf Dorian, Samadov, Elgun, Ibrahimli, Arturan, Muslumov, Gurbankhan, Bayramov, Nuru Y, Saunders, Jada M, Almoosa, Noora, Haj-Ibrahim, Huzifa, Maresch, Martin, Ezzdean, Weaam K, Juma, Isam M, Hasan, Layla H, Haider, Fayza HA, Alfaqawi, 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Blanco, Jose A, Chituku, Tsitsi G, Dixon, Oliver GB, sarveswaran, Janahan, Jones, Imogen S, Hammouche, Salah, Vijay, Vardhini, Ooi, Rucira, Karmarkar, Rahi, Khaleeq, Tahir, Bhatia, Mohit, Al-Khazaali, Badr L, Daadipour, Audrina, Mattar, Ahmed, Singhal, Tarun, Mahmoud, Moustafa Ibrahim, Glasbey, James, Nankivell, Paul C, Kalkat, Maninder S, Nour, Shahd, Beggs, Andrew D, Yershov, Danylo Y, Chughtai, Shafiq Ahmad, Youssef, Hesham, Norrish, Alan R, Mohammed, Mohammed M, Gwozdz, Adam M, Charalambous, Michalis P, Knight, Stephen R, McCaul, James A, Bridgman, Elsie A, El Sheikh, Mustafa, Ogunbowale, Akinsola, Wright, Evan O, Ahmed, Usama, Younus, Hafsa, Tincknell, Laura G, Weixing-Ho, Ken, Demetriou, Charis, Hussei, Mohammed, Reilly, John-Joe, Hormis, Anil P, Moug, Susan J, Anazor, Fitzgerald C, Horwell, Edward A, Neal-Smith, Gregory, McNamara, John M, Baryeh, Kwaku W, Bhatti, Khalid M, McKay, Joseph E, Cannoletta, Maria G, Perkins, Clare J, Gopalswamy, Sivakumar, Sheldon, Anna F, John, Joseph B, Mantle, Mark, Toia, Bogdan, Phillips, Andrew J, Al-Khyatt, Waleed, Lund, Jonathan N, Ammar, Ahmed Y, Lederhuber, Hans, Yim, Guang H, Huntley, Daniel A, Daniels, Ian R, Valverde, Joao, Lumley, Edward David John, Walton, Thomas J, Raptis, Dimitri A, Dimitrokallis, Nikolaos, Nathan, Arjun, Motallebzadeh, Reza, Chowdhury, Shihab, Ahmed, Rezwan F A, Mirnezami, Reza, Szakmany, Tamas, Knight, Dominic J, Al-Azzani, Waheeb, Davies, Huw R, Ooi, Setthasorn Zhi Yang, Oo, Khaing K, Cullis, Paul S, Peng, Ed, Demetriades, Andreas K, Tambyraja, Andrew L, Poon, Michael TC, Drake, Thomas M, Brennan, Paul M, Oikonomou, Dimitrios, Newman, Samuel E, Le Blevec, Louise, Otify, Mohamed, Szatmary, Peter, Devkaran, Bhavesh, Sochorova, Dana, Sohrabi, Catrin, Sivaprakasam, Rajesh, Goh, Mingzheng Aaron, Atkinson, Kate V, Soares, Delvene, Prce, Daniela, Cann, Johnathon P, Grobbelaar, Amy C, Bradley, Rebecca, Strauss, Helen J, Taha, Ahmed, Minicozzi, Annamaria, Venn, Mary L, Thakur, Bhaskar, Hanoun, Abdullah, Goru, Poornanand, Baumber, Rachel M, Sobti, Anshul S, Cross, George WV, Havenhand, Tom, Antoniou, George A, Chauhan, Govind Singh, Vokshi, Ismail, Mahmud, Ayesha, Albanese, Erminia, Evans, Daisy, Madhuri, Thumuluru Kavitha, Horsnell, Jonathan D, Zalmay, Pardis, Mohamed, Mazin, Davies, Angharad J, Aljanadi, Firas, Jeganathan, Reubendra, Jones, Mark, Kakos, Christos, vidya, Raghavan, El-Ghobashy, Alaa, Habib, Ahmed M, Reid, Jeremy P, Rajgor, Harshadkumar Dhirajlal, Ahmed, Omar, Branagan, Graham, Mohamedahmed, Ali Yasen Y, Nour, Shahd, Al-Sabbagh, Ali, Chetty, Govind, Kelty, Clive J, EL-Wajeh, Yasin A M, Tomlinson, James E, Edwards, John G, Rominiyi, Ola, Sinha, Saurabh, Saad, Sanad, Sahu, Banchhita, Charalampakis, Vasileios, Enemosah, Ibrahim, Williams, Simon J, Yaqoob, Hassan N, Laurent, Edward P, Moreau, Joshua L, Frostick, Rhiannon, Parwaiz, Hammad, Aboelmagd, Karim, Pournaras, Dimitri J, Hristova, Kalina H, Iyengar, Karthikeyan P, Mohamed, Muyed, Artioukh, Dmitri Y, Anwar, Sibtain, Hussein, Mostafa K A, Omogbehin, Tomisin S, Herron, Jonathan B T, Labib, Amir, Patel, Preemal, Marsden, Samuel C, Mehdian, Roshana, Santhirakumaran, Gowthanan, Smelt, Jeremy, Agarwal, Ketan, Athanasiou, Antonios, Lancerotto, Luca, Sahnan, Kapil, Shalhoub, Joseph, Donnelly, Liam J, Erridge, Simon, Chidambaram, Swathikan, Luo, Xun, Bansal, Sujesh, Ryan, Neil AJ, Smith, Alexander C D, Flatman, Michael, Wafaie, Imad, Malik, Muhammad Isfandyar Khan, Thumbadoo, Ruben P, Hussain, Shoaib F, Henein, Christin, Hamad, Yousif T, Belgaumkar, Ajay P, Bosanquet, David C, Kolias, Angelos G, Choi, David, Marcus, Hani J, Horsfall, Hugo RM Layard, Khan, Danyal Z, Sahni, Arun, Millward, Christopher P, Render, Luke, Truss, Adam, Elmoslemany, Tarek, Parmar, Chetan, Hanger, Joseph, Sheen, Jonathon, Rait, Jaideep S, Foreman, Jennifer, Marzouqa, Natalie, Fontalis, Andreas, Voulalas, Grigorios, CHEONG, Ryan Chin Taw, Dindyal, Sanjay, Arumugam, Sathyaseelan, Ward, Thomas R W, Stephens, Alastair S, Douka, Eleftheria, Mahmud, Ayesha, Abou-Foul, Ahmad K, McKay, Siobhan C, Kitchen, Mark O, Rees-Stoner, Oliver DJ, Balasubramanya, Supriya, Akhtar, Muhammad Adeel, Warwick, Andrew J, Pawar, Shweta, Dubey, Vivek, Al-Yaseen, Mustafa W, Williams, Christopher YK, Laird, Alexander, Krishna, Kandaswamy, Anyaugo, Ngozi S, Wuraola, Obafemi K, Odejinmi, Funlayo, Craven, Joanna M, West, Charlotte L, Barter, Reece A, Navaratnam, Devaraj M, Malik, Shahbaz S, Mahendran, Vimaladhithan, Zilvetti, Miguel, Lovegrove, Richard E, Board, Tim N, Zeiton, Moez, Sarwar, Safdar A, Duff, Sarah E, Hsabo, Elmuiz A, Goru, Poornanand, Nugur, Ashwani Kumar, Morris, Richard M, Lala, Anil K, Kwan-Feinberg, Rita O, Ross, Samuel W, Dressler, Jeremy A, McClain, Craig D, Evans, Faye M, Wason, Shaun E L, Vogel, Keianna R, Wang, Joanna C, Sulciner, Megan L, Hirji, Sameer, Raoof, Mustafa, Wolff, Christopher J, kent, Ilan, Turan, Alparslan, Teixeira, Pedro G, Olson, Kristofor A, Patel, Neil D, Krishnamoorthy, Vijay, Moris, Dimitrios, Rice, Henry E, Gabr, Hesham, Satoskar, Savni R, Castater, Christine A, Jmaileh, Manal, Payne, Rachel E, Kwon, David S, Aarabi, Shahram, Escobar, Pedro F, Kronenfeld, Joshua P, Dalton, Michael K, Etchill, Eric W, Haut, Elliott R, Vervoort, Dominique, Dehal, Ahmed, McKenney, Mark, Elkbuli, Adel, Gosain, Ankush, Abdelsattar, Zaid M, Naunheim, Matthew R, Burks, Ciersten A, Zhou, Allen S, Heng, Marilyn, Abohashem, Shady, Lozano-Calderón, Santiago A, Reisenauer, Janani S, Mouawad, Nicolas J, Diehl, Thomas M, Eriksson, Evert A, Marwaha, Jayson S, Schroeppel, Thomas J, LaRocca, Christopher J, Chang, Grace H, Hassan, Romana, Nosanov, Lauren B, Rickard, Jennifer L, Avraham, Jacob B, Petrone, Patrizio, Sferra, Joseph J, Hadaya, Joseph, Mead, Brittany S, Hauptman, Jason S, Ahmad, Maleeha, Meola, Antonio, Chang, Steven D, Ko, Ara, Specht, Katherine E, Choudhry, Asad, Encalada, Ronald Zerna, Poggio, Juan L, Xing, Hang, Glass, Nina E, Hooker, Robert, Martins, Paulo N, Scott, Erin M, Bankhead, Brittany K, Giorgakis, Emmanouil, Nigh, Joe, Osborn, Tamara, Tay Lasso, Erika L, Beswick, Daniel M, Berndtson, Allison E, Kaups, Krista L, Chen, Lee-lynn, Farrell, Michael S, Boeck, Marissa A, Vaysburg, Dennis M, Kassam, Al-Faraaz, Turner, Kevin M, Dyas, Adam R, Coleman, Julia R, Folsom, Megan, Lam, Christopher M, Kumer, Sean C, Larson, Kelsey, Turner, Scott, Guidry, Christopher, Reddy, Madhuri, Berbel, German, Findley, Austin, Beahm, David, Bur, Andres, Marlor, Derek, Houndschell, Corey, Carver, Shea, Ulrich, Alissa, Bhutiani, Neal, DiChiacchio, Laura, Abdou, Hossam, Napolitano, Lena M, Ghebre, Rahel, Bass, Gary Alan, Kaplan, Lewis J, Martin, Niels D, Duffy, Caoimhe C, Abdelhamid, Sultan S, Daley, Brian J, Roland, Christina L, Dumas, Ryan P, Ban, Vin Shen, Rajesh, Aashish, Davies, Mark G, Purudappa, Prabhudev P, Walters, Camila B, Lin, Nicole, Ruzgar, Nensi M, Ullrich, Sarah J, Trostchansky, Ivan, Bonilla-Cal, Fernando, Castedo, Fabiola, Sobrero, Helena, Acuña, Gastón, Álvarez, Sofía M, Tarigo, Josefina, Carbajal, Ana C, Carbajal, Ana, Reyes, Antonio R, Al-Eryani, Fatima A, Alqousi, Nardeen N, Alattas, Zainab, Al-Saban, Rafat A, Al-Shehari, Mohammed M, ALHammadi, Nawal T, Shream, Sarah A, Al-Naggar, Hamza M, Al-Qalisi, Lina M, Nadeesh, Areej E, Al-Samawi, Hytham H, Bajjah, Hadeel M, AL-Ameri, Saba A, Albably, Jamal F, Ghannam, Rana A, Shamsan, Amatallah H, Meead, Abdullah A, Al- Zubaidi, Riham Q, Zulait, Mohammed A, Najeeb, Halah, Alsayadi, Musaed M, Al-Mashreqi, Seham K, Al-Jomai, Najla A, Alsayadi, Ramzi A, Al-Naggar, Moath M, Almarashi, Hassan A, Musaeed, Hasna M, Al-Raimi, Ibrahim M, Ghanem, Hossam N, Al-Zazay, Karim A, AL-Mahdi, Shehab A, Almontaser, Amatalaleem S, Savopoulos, Vanessa A S, Munthali, James, Kabongo, Kizito M C, Mushiwokufa, Willard, Ngulube, Allan, Ntoto, Crispin, Magama, Praise T, Dzinotyiwei, Daniel, Chivanga, Shelton K, Dube, Ngqabutho S, Sanchez, Ernesto C, Moyo, Assel T, Chengahomwe, Antony, Chinyowa, Simbarashe, Siamuchembu, Maphios, Bondera, Tafadzwa, and Mushawarima, Trust
- Abstract
The 2015 LancetCommission on global surgery identified surgery and anaesthesia as indispensable parts of holistic health-care systems. However, COVID-19 exposed the fragility of planned surgical services around the world, which have also been neglected in pandemic recovery planning. This study aimed to develop and validate a novel index to support local elective surgical system strengthening and address growing backlogs.
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- 2022
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230. Mental pain as a global person-centered outcome measure
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Cosci, Fiammetta, Mansueto, Giovanni, Benemei, Silvia, Chiarugi, Alberto, De Cesaris, Francesco, and Sensky, Tom
- Abstract
AbstractBackgroundMental pain has been proposed as a global person-centered outcome measure. The aim of this cross-sectional study was to test an essential requisite of such a measure, namely that mental pain incorporates independent contributions from a range of discrete but disparate outcome measures.MethodsTwo hundred migraine patients were assessed concerning migraine disability, psychosomatic syndromes, mental pain, depression, anxiety, and psychosocial dimensions. General linear models were tested to verify which measures would individually make unique contributions to overall mental pain.ResultsThe final model, accounting for 44% of variance, identified that higher mental pain was associated with more severe depressive symptoms, higher migraine disability, lower well-being, and poorer quality of life.ConclusionIn this sample, mental pain was shown to behave as expected of a global outcome measure, since multiple measures of symptomatology and quality of life showed modest but significant bivariate correlations with mental pain and some of these measures individually made unique contributions to overall mental pain.
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- 2022
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231. Changes in Kynurenic, Anthranilic, and Quinolinic Acid Concentrations in Rat Brain Tissue During Development
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Cannazza, Giuseppe, Chiarugi, Alberto, Parenti, Carlo, Zanoli, Paola, and Baraldi, Mario
- Published
- 2001
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232. Tumor microenvironment and oxidative stress: involvement in metabolic reprogramming and chemo-resistance of prostate cancer cells: Cancer and Ageing 2
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Taddei, M. L., Fiaschi, T., Marini, A., Farini, V., Stinziani, S., and Chiarugi, P.
- Published
- 2012
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233. The pre-procedural platelet state predicts clinical recurrence after coronary angioplasty
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Capanni, M., Prisco, D., Antonucci, E., Chiarugi, L., Abbate, R., Giglioli, C., Dabizzi, R. P., Margheri, M., Simonetti, I., Gensini, G. F., and Boddi, V.
- Published
- 1999
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234. The influence of smoking on von Willebrand factor is already manifest in healthy adolescent females: the Floren-teen (Florence Teenager) Study
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Prisco, D., Fedi, S., Brunelli, T., Chiarugi, L., Lombardi, A., Pepe, G., Gensini, G. F., Abbate, R., Gianni, R., Santoro, E., Cappelletti, C., and Pepe, G.
- Published
- 1999
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235. Metabolic cell communication within tumour microenvironment: models, methods and perspectives
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Parri, M, primary, Ippolito, L, additional, Cirri, P, additional, Ramazzotti, M, additional, and Chiarugi, P, additional
- Published
- 2020
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236. Mitochondrial oxidative metabolism contributes to maintain a cancer stem cell phenotype in cholangiocarcinoma
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Raggi, C., primary, Taddei, M.L., additional, Sacco, E., additional, Navari, N., additional, Correnti, M., additional, Piombanti, B., additional, Pastore, M., additional, Iorio, J., additional, Lori, G., additional, Peano, C., additional, Cibella, J., additional, Lewinska, M., additional, Andersen, J.B., additional, Di Maira, G., additional, Ramazzotti, M., additional, Orlandi, Ivan, additional, Chiarugi, P., additional, and Marra, F., additional
- Published
- 2020
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237. Hepatocyte-specific deletion of ERK5 worsens insulin resistance in a murine model of nonalcoholic fatty liver disease (NAFLD)
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Di Maira, G., primary, Lori, G., additional, Piombanti, B., additional, Taddei, M.L., additional, Parri, M., additional, Chiarugi, P., additional, Tournier, C., additional, Rovida, E., additional, and Marra, F., additional
- Published
- 2020
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238. Streptococcus bovis endocarditis as first clinical expression of an occult colorectal neoplasm
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Fregoli, Lorenzo, Palmeri, Matteo, Palombo, Carlo, Pelosini, Marco, Taddei, Claudia, Miccoli, Paolo, and Chiarugi, Massimo
- Published
- 2015
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239. An in vitro molecular study of the Nicotiana tabacum L. genome in the presence or absence of the herbicide atrazine
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Bettini, P., Chiarugi, P., and Buiatti, M.
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- 1998
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240. Laparoscopically assisted abdominoperineal resection and simultaneous total anorectal reconstruction with electrostimulated static-dynamic graciloplasty
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Cavina, E., Seccia, M., Chiarugi, M., Banti, P., and Zocco, G.
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- 1997
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241. Regulation of p53 by protein kinase C during multi-stage carcinogenesis
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Magnelli, Lucia and Chiarugi, Vincenzo
- Published
- 1997
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242. Acquisition of stem-like features in human cholangiocarcinoma is associated with an oxidative metabolism
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Raggi, C., Navari, N., Taddei, M.l., Sacco, E., Correnti, M., Piombanti, B., Andersen, J.B., Ramazzotti, M., Orlandi, I., Chiarugi, P., Marra, F., Raggi, C., Navari, N., Taddei, M.l., Sacco, E., Correnti, M., Piombanti, B., Andersen, J.B., Ramazzotti, M., Orlandi, I., Chiarugi, P., and Marra, F.
- Published
- 2019
243. Perineal colostomy and electrostimulated gracilis “neosphincter” after abdomino-perineal resection of the colon and anorectum: a surgical experience and follow-up study in 47 cases
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Cavina, E., Seccia, M., Evangelista, G., Chiarugi, M., Buccianti, P., Tortora, A., and Chirico, A.
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- 1990
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244. Trocar site tumor recurrences: May pneumoperitoneum be responsible?
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Cavina, E., Goletti, O., Molea, N., Buccianti, P., Chiarugi, M., Boni, G., Lazzeri, E., and Bianchi, R.
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- 1998
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245. Oncogenes, p53, and tumor angiogenesis
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Chiarugi, Vincenzo, Magnelli, Lucia, Cinelli, Marina, and Ruggiero, Marco
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- 1998
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246. Erratum to: Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer (Nature Genetics, (2018), 50, 2, (219-228), 10.1038/s41588-017-0026-3)
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Chen, J., Guccini, I., Di Mitri, D., Brina, D., Revandkar, A., Sarti, M., Pasquini, E., Alajati, A., Pinton, S., Losa, M., Civenni, G., Catapano, C. V., Sgrignani, J., Cavalli, A., D'Antuono, R., Asara, J. M., Morandi, A., Chiarugi, P., Crotti, S., Agostini, M., Montopoli, M., Masgras, I., Rasola, A., Garcia-Escudero, R., Delaleu, N., Rinaldi, A., Bertoni, F., de Bono, J., Carracedo, A., and Alimonti, A.
- Published
- 2018
247. Hepatocyte expression of the protein kinase ERK5 regulates insulin sensitivity
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Di Maira, G., primary, Lori, G., additional, Piombanti, B., additional, Taddei, M.L., additional, Parri, M., additional, Rovida, E., additional, Chiarugi, P., additional, and Marra, F., additional
- Published
- 2019
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248. Acquisition of stem-like features in human cholangiocarcinoma is associated with an oxidative metabolism
- Author
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Raggi, C., primary, Navari, N., additional, Taddei, M.L., additional, Sacco, E., additional, Correnti, M., additional, Piombanti, B., additional, Andersen, J.B., additional, Ramazzotti, M., additional, Orlandi, I., additional, Chiarugi, P., additional, and Marra, F., additional
- Published
- 2019
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249. Laparoscopic versus open repair of perforated peptic ulcers: analysis of outcomes and identification of predictive factors of conversion
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Tartaglia, Dario, Strambi, Silvia, Coccolini, Federico, Mazzoni, Alessio, Miccoli, Mario, Cremonini, Camilla, Cicuttin, Enrico, and Chiarugi, Massimo
- Abstract
Background: The surgical treatment for perforated peptic ulcers (PPUs) can be safely performed laparoscopically. This study aimed to compare the outcomes of patients who received different surgical approaches for PPU and to identify the predictive factors for conversion to open surgery. Methods: This retrospective study analyzed patients treated for PPUs from 2002 to 2020. Three groups were identified: a complete laparoscopic surgery group (LG), a conversion to open group (CG), and a primary open group (OG). After univariate comparisons, a multivariate analysis was conducted to identify the predictive factors for conversion. Results: Of the 175 patients that underwent surgery for PPU, 104 (59.4%) received a laparoscopic-first approach, and 27 (25.9%) required a conversion to open surgery. Patients treated directly with an open approach were older (p< 0.0001), had more comorbidities (p< 0.0001), and more frequently had a previous laparotomy (p= 0.0001). In the OG group, in-hospital mortality and ICU need were significantly higher, while the postoperative stay was longer. Previous abdominal surgery (OR 0.086, 95% CI 0.012–0.626; p= 0.015), ulcer size (OR 0.045, 95% CI 0.010–0.210; p< 0.0001), and a posterior ulcer location (OR 0.015, 95% CI 0.001–0.400; p= 0.012) were predictive factors for conversion to an open approach. Conclusion: This study confirms the benefits of the laparoscopic approach for the treatment of PPUs. Previous laparotomies, a greater ulcer size, and a posterior location of the ulcer are risk factors for conversion to open surgery during laparoscopic repair.
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- 2022
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250. Escaping from, moving towards, following a path, squeezing through: lots of opportunities for moving cells
- Author
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Chiarugi Paola
- Subjects
Medicine ,Cytology ,QH573-671 - Published
- 2010
- Full Text
- View/download PDF
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