18,220 results on '"Cheng, Hao"'
Search Results
202. Recent progress in unraveling cardiovascular complications associated with primary aldosteronism: a succinct review
- Author
-
Wang, Wei-Ting, Wu, Tsung-Hui, Er, Leay-Kiaw, Huang, Chien-Wei, Tu, Kun-Hua, Fan, Kang-Chih, Tsai, Cheng-Hsuan, Wang, Shu-Yi, Wu, Chun-Yi, Huang, Shu-Heng, Liu, Han-Wen, Tseng, Fen-Yu, Wu, Wan-Chen, Chang, Chin-Chen, Cheng, Hao-Min, Lin, Liang-Yu, Chueh, Jeff S., Lin, Yen-Hung, Hwu, Chii-Min, and Wu, Vin-Cent
- Published
- 2024
- Full Text
- View/download PDF
203. Can cross-holdings benefit consumers?
- Author
-
Cheng, Hao, Wu, Xiaoting, and Zeng, Chenhang
- Published
- 2024
- Full Text
- View/download PDF
204. Study on the Purification Effect and Mechanism of Micro–Nano-Bubble-Based Two-Stage Air Floatation Method on the Raw Sugar Redissolved Syrup
- Author
-
Cheng, Hao, Tang, Tingfan, Meng, Qiubai, Zhang, Wenkang, and Li, Lijun
- Published
- 2024
- Full Text
- View/download PDF
205. Registered report adoption in academic journals: assessing rates in different research domains
- Author
-
Lin, Ting-Yu, Cheng, Hao-Chien, Cheng, Li-Fu, and Hung, Tsung-Min
- Published
- 2024
- Full Text
- View/download PDF
206. Optimum splitting computing for DNN training through next generation smart networks: a multi-tier deep reinforcement learning approach
- Author
-
Lien, Shao-Yu, Yeh, Cheng-Hao, and Deng, Der-Jiunn
- Published
- 2024
- Full Text
- View/download PDF
207. The costs and opportunities of overload: exploring the double-edged sword effect of unreasonable tasks on thriving at work
- Author
-
Li, Zhen, Cheng, Hao, Gao, Rong, Teng, Rongrong, Zhao, Junshu, Yue, Longhua, Li, Fangfang, and Liao, Qianyi
- Published
- 2024
- Full Text
- View/download PDF
208. Cation replacement method enables high-performance electrolytes for multivalent metal batteries
- Author
-
Li, Siyuan, Zhang, Jiahui, Zhang, Shichao, Liu, Qilei, Cheng, Hao, Fan, Lei, Zhang, Weidong, Wang, Xinyang, Wu, Qian, and Lu, Yingying
- Published
- 2024
- Full Text
- View/download PDF
209. Lattice-Aided Extraction of Spread-Spectrum Hidden Data
- Author
-
Yang, Fan, Lyu, Shanxiang, Cheng, Hao, Wen, Jinming, and Chen, Hao
- Subjects
Computer Science - Cryptography and Security - Abstract
This paper discusses the problem of extracting spread spectrum hidden data from the perspective of lattice decoding. Since the conventional blind extraction scheme multi-carrier iterative generalize least-squares (M-IGLS) and non-blind extraction scheme minimum mean square error (MMSE) suffer from performance degradation when the carriers lack sufficient orthogonality, we present two novel schemes from the viewpoint of lattice decoding, namely multi-carrier iterative successive interference cancellation (M-ISIC) and sphere decoding (SD). The better performance of M-ISIC and SD are confirmed by both theoretical justification and numerical simulations., Comment: 10 pages
- Published
- 2023
210. Self-Verification Improves Few-Shot Clinical Information Extraction
- Author
-
Gero, Zelalem, Singh, Chandan, Cheng, Hao, Naumann, Tristan, Galley, Michel, Gao, Jianfeng, and Poon, Hoifung
- Subjects
Computer Science - Computation and Language ,Computer Science - Machine Learning - Abstract
Extracting patient information from unstructured text is a critical task in health decision-support and clinical research. Large language models (LLMs) have shown the potential to accelerate clinical curation via few-shot in-context learning, in contrast to supervised learning which requires much more costly human annotations. However, despite drastic advances in modern LLMs such as GPT-4, they still struggle with issues regarding accuracy and interpretability, especially in mission-critical domains such as health. Here, we explore a general mitigation framework using self-verification, which leverages the LLM to provide provenance for its own extraction and check its own outputs. This is made possible by the asymmetry between verification and generation, where the latter is often much easier than the former. Experimental results show that our method consistently improves accuracy for various LLMs in standard clinical information extraction tasks. Additionally, self-verification yields interpretations in the form of a short text span corresponding to each output, which makes it very efficient for human experts to audit the results, paving the way towards trustworthy extraction of clinical information in resource-constrained scenarios. To facilitate future research in this direction, we release our code and prompts.
- Published
- 2023
211. Is Silent eHMI Enough? A Passenger-Centric Study on Effective eHMI for Autonomous Personal Mobility Vehicles in the Field
- Author
-
Liu, Hailong, Li, Yang, Zeng, Zhe, Cheng, Hao, Peng, Chen, and Wada, Takahiro
- Subjects
Computer Science - Human-Computer Interaction - Abstract
Autonomous Personal Mobility Vehicle (APMV) is a miniaturized autonomous vehicle designed to provide short-distance mobility to everyone in pedestrian-rich environments. By the characteristic of the open design, passengers on the APMV are exposed to the communication between the eHMI deployed on APMVs and pedestrians. Therefore, to ensure an optimal passenger experience, eHMI designs for APMVs must consider the potential impact of APMV-pedestrian communications on passengers' subjective feelings. To this end, this study discussed three external human-machine interface (eHMI) designs, i.e., 1) graphical user interface (GUI)-based eHMI with text message (eHMI-T), 2) multimodal user interface (MUI)-based eHMI with neutral voice (eHMI-NV), and 3) MUI-based eHMI with affective voice (eHMI-AV), from the perspective of APMV passengers in the communication between APMV and pedestrians. In the riding field experiment (N=24), we found that eHMI-T may be less suitable for APMVs. This conclusion was drawn based on passengers' feedback, as they expressed an awkward feeling during the "silent time" when the eHMI-T provided information only to pedestrians but not to passengers. Additionally, these two MUI-based eHMIs with voice cues had their own advantages, i.e., eHMI-NV has an advantage in pragmatic quality, while eHMI-AV has an advantage in hedonic quality. The study also highlights the necessity of considering passengers' personalities when desig
- Published
- 2023
- Full Text
- View/download PDF
212. Pre-training Multi-task Contrastive Learning Models for Scientific Literature Understanding
- Author
-
Zhang, Yu, Cheng, Hao, Shen, Zhihong, Liu, Xiaodong, Wang, Ye-Yi, and Gao, Jianfeng
- Subjects
Computer Science - Computation and Language ,Computer Science - Digital Libraries ,Computer Science - Information Retrieval ,Computer Science - Machine Learning - Abstract
Scientific literature understanding tasks have gained significant attention due to their potential to accelerate scientific discovery. Pre-trained language models (LMs) have shown effectiveness in these tasks, especially when tuned via contrastive learning. However, jointly utilizing pre-training data across multiple heterogeneous tasks (e.g., extreme multi-label paper classification, citation prediction, and literature search) remains largely unexplored. To bridge this gap, we propose a multi-task contrastive learning framework, SciMult, with a focus on facilitating common knowledge sharing across different scientific literature understanding tasks while preventing task-specific skills from interfering with each other. To be specific, we explore two techniques -- task-aware specialization and instruction tuning. The former adopts a Mixture-of-Experts Transformer architecture with task-aware sub-layers; the latter prepends task-specific instructions to the input text so as to produce task-aware outputs. Extensive experiments on a comprehensive collection of benchmark datasets verify the effectiveness of our task-aware specialization strategy, where we outperform state-of-the-art scientific pre-trained LMs. Code, datasets, and pre-trained models can be found at https://scimult.github.io/., Comment: 17 pages; Accepted to Findings of EMNLP 2023 (Project Page: https://scimult.github.io/)
- Published
- 2023
213. Chain-of-Skills: A Configurable Model for Open-domain Question Answering
- Author
-
Ma, Kaixin, Cheng, Hao, Zhang, Yu, Liu, Xiaodong, Nyberg, Eric, and Gao, Jianfeng
- Subjects
Computer Science - Computation and Language - Abstract
The retrieval model is an indispensable component for real-world knowledge-intensive tasks, e.g., open-domain question answering (ODQA). As separate retrieval skills are annotated for different datasets, recent work focuses on customized methods, limiting the model transferability and scalability. In this work, we propose a modular retriever where individual modules correspond to key skills that can be reused across datasets. Our approach supports flexible skill configurations based on the target domain to boost performance. To mitigate task interference, we design a novel modularization parameterization inspired by sparse Transformer. We demonstrate that our model can benefit from self-supervised pretraining on Wikipedia and fine-tuning using multiple ODQA datasets, both in a multi-task fashion. Our approach outperforms recent self-supervised retrievers in zero-shot evaluations and achieves state-of-the-art fine-tuned retrieval performance on NQ, HotpotQA and OTT-QA., Comment: ACL 2023
- Published
- 2023
214. Evaluating the Efficacy of Length-Controllable Machine Translation
- Author
-
Cheng, Hao, Zhang, Meng, Wang, Weixuan, Li, Liangyou, Liu, Qun, and Zhang, Zhihua
- Subjects
Computer Science - Computation and Language ,Computer Science - Artificial Intelligence - Abstract
Length-controllable machine translation is a type of constrained translation. It aims to contain the original meaning as much as possible while controlling the length of the translation. We can use automatic summarization or machine translation evaluation metrics for length-controllable machine translation, but this is not necessarily suitable and accurate. This work is the first attempt to evaluate the automatic metrics for length-controllable machine translation tasks systematically. We conduct a rigorous human evaluation on two translation directions and evaluate 18 summarization or translation evaluation metrics. We find that BLEURT and COMET have the highest correlation with human evaluation and are most suitable as evaluation metrics for length-controllable machine translation.
- Published
- 2023
215. End-to-end Training and Decoding for Pivot-based Cascaded Translation Model
- Author
-
Cheng, Hao, Zhang, Meng, Li, Liangyou, Liu, Qun, and Zhang, Zhihua
- Subjects
Computer Science - Computation and Language ,Computer Science - Artificial Intelligence - Abstract
Utilizing pivot language effectively can significantly improve low-resource machine translation. Usually, the two translation models, source-pivot and pivot-target, are trained individually and do not utilize the limited (source, target) parallel data. This work proposes an end-to-end training method for the cascaded translation model and configures an improved decoding algorithm. The input of the pivot-target model is modified to weighted pivot embedding based on the probability distribution output by the source-pivot model. This allows the model to be trained end-to-end. In addition, we mitigate the inconsistency between tokens and probability distributions while using beam search in pivot decoding. Experiments demonstrate that our method enhances the quality of translation.
- Published
- 2023
216. Improve Video Representation with Temporal Adversarial Augmentation
- Author
-
Duan, Jinhao, Fan, Quanfu, Cheng, Hao, Shi, Xiaoshuang, and Xu, Kaidi
- Subjects
Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Artificial Intelligence - Abstract
Recent works reveal that adversarial augmentation benefits the generalization of neural networks (NNs) if used in an appropriate manner. In this paper, we introduce Temporal Adversarial Augmentation (TA), a novel video augmentation technique that utilizes temporal attention. Unlike conventional adversarial augmentation, TA is specifically designed to shift the attention distributions of neural networks with respect to video clips by maximizing a temporal-related loss function. We demonstrate that TA will obtain diverse temporal views, which significantly affect the focus of neural networks. Training with these examples remedies the flaw of unbalanced temporal information perception and enhances the ability to defend against temporal shifts, ultimately leading to better generalization. To leverage TA, we propose Temporal Video Adversarial Fine-tuning (TAF) framework for improving video representations. TAF is a model-agnostic, generic, and interpretability-friendly training strategy. We evaluate TAF with four powerful models (TSM, GST, TAM, and TPN) over three challenging temporal-related benchmarks (Something-something V1&V2 and diving48). Experimental results demonstrate that TAF effectively improves the test accuracy of these models with notable margins without introducing additional parameters or computational costs. As a byproduct, TAF also improves the robustness under out-of-distribution (OOD) settings. Code is available at https://github.com/jinhaoduan/TAF., Comment: To be appeared in IJCAI 2023
- Published
- 2023
217. The Mutual Information In The Vicinity of Capacity-Achieving Input Distributions
- Author
-
Nakiboğlu, Barış and Cheng, Hao-Chung
- Subjects
Computer Science - Information Theory ,Quantum Physics - Abstract
The mutual information is bounded from above by a decreasing affine function of the square of the distance between the input distribution and the set of all capacity-achieving input distributions $\Pi_{\mathcal{A}}$, on small enough neighborhoods of $\Pi_{\mathcal{A}}$, using an identity due to Tops{\o}e and the Pinsker's inequality, assuming that the input set of the channel is finite and the constraint set $\mathcal{A}$ is polyhedral, i.e., can be described by (possibly multiple but) finitely many linear constraints. Counterexamples demonstrating nonexistence of such a quadratic bound are provided for the case of infinitely many linear constraints and the case of infinite input sets. Using Taylor's theorem with the remainder term, rather than the Pinsker's inequality and invoking Moreau's decomposition theorem the exact characterization of the slowest decrease of the mutual information with the distance to $\Pi_{\mathcal{A}}$ is determined on small neighborhoods of $\Pi_{\mathcal{A}}$. Corresponding results for classical-quantum channels are established under separable output Hilbert space assumption for the quadratic bound and under finite-dimensional output Hilbert space assumption for the exact characterization. Implications of these observations for the channel coding problem and applications of the proof techniques to related problems are discussed., Comment: 17 pages, presented at ISIT 2023, submitted to IEEE Transactions on Information Theory on June 13, 2023, revised on September 6, 2024
- Published
- 2023
218. Quantum Broadcast Channel Simulation via Multipartite Convex Splitting
- Author
-
Cheng, Hao-Chung, Gao, Li, and Berta, Mario
- Subjects
Quantum Physics ,Computer Science - Information Theory ,Mathematical Physics - Abstract
We show that the communication cost of quantum broadcast channel simulation under free entanglement assistance between the sender and the receivers is asymptotically characterized by an efficiently computable single-letter formula in terms of the channel's multipartite mutual information. Our core contribution is a new one-shot achievability result for multipartite quantum state splitting via multipartite convex splitting. As part of this, we face a general instance of the quantum joint typicality problem with arbitrarily overlapping marginals. The crucial technical ingredient to sidestep this difficulty is a conceptually novel multipartite mean-zero decomposition lemma, together with employing recently introduced complex interpolation techniques for sandwiched R\'enyi divergences. Moreover, we establish an exponential convergence of the simulation error when the communication costs are within the interior of the capacity region. As the costs approach the boundary of the capacity region moderately quickly, we show that the error still vanishes asymptotically., Comment: The idea of the mean-zero decomposition lemma is independently and concurrently discovered for multipartite decoupling by Pau Colomer Saus and Andreas Winter (arXiv:2304.12114). v2: References updated
- Published
- 2023
219. Tight One-Shot Analysis for Convex Splitting with Applications in Quantum Information Theory
- Author
-
Cheng, Hao-Chung and Gao, Li
- Subjects
Quantum Physics ,Computer Science - Information Theory ,Mathematical Physics - Abstract
Convex splitting is a powerful technique in quantum information theory used in proving the achievability of numerous information-processing protocols such as quantum state redistribution and quantum network channel coding. In this work, we establish a one-shot error exponent and a one-shot strong converse for convex splitting with trace distance as an error criterion. Our results show that the derived error exponent (strong converse exponent) is positive if and only if the rate is in (outside) the achievable region. This leads to new one-shot exponent results in various tasks such as communication over quantum wiretap channels, secret key distillation, one-way quantum message compression, quantum measurement simulation, and quantum channel coding with side information at the transmitter. We also establish a near-optimal one-shot characterization of the sample complexity for convex splitting, which yields matched second-order asymptotics. This then leads to stronger one-shot analysis in many quantum information-theoretic tasks., Comment: v2: Adding an additivity property (Proposition 23)
- Published
- 2023
220. Chameleon: Plug-and-Play Compositional Reasoning with Large Language Models
- Author
-
Lu, Pan, Peng, Baolin, Cheng, Hao, Galley, Michel, Chang, Kai-Wei, Wu, Ying Nian, Zhu, Song-Chun, and Gao, Jianfeng
- Subjects
Computer Science - Computation and Language ,Computer Science - Artificial Intelligence ,Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Machine Learning - Abstract
Large language models (LLMs) have achieved remarkable progress in solving various natural language processing tasks due to emergent reasoning abilities. However, LLMs have inherent limitations as they are incapable of accessing up-to-date information (stored on the Web or in task-specific knowledge bases), using external tools, and performing precise mathematical and logical reasoning. In this paper, we present Chameleon, an AI system that mitigates these limitations by augmenting LLMs with plug-and-play modules for compositional reasoning. Chameleon synthesizes programs by composing various tools (e.g., LLMs, off-the-shelf vision models, web search engines, Python functions, and heuristic-based modules) for accomplishing complex reasoning tasks. At the heart of Chameleon is an LLM-based planner that assembles a sequence of tools to execute to generate the final response. We showcase the effectiveness of Chameleon on two multi-modal knowledge-intensive reasoning tasks: ScienceQA and TabMWP. Chameleon, powered by GPT-4, achieves an 86.54% overall accuracy on ScienceQA, improving the best published few-shot result by 11.37%. On TabMWP, GPT-4-powered Chameleon improves the accuracy by 17.0%, lifting the state of the art to 98.78%. Our analysis also shows that the GPT-4-powered planner exhibits more consistent and rational tool selection via inferring potential constraints from instructions, compared to a ChatGPT-powered planner. The project is available at https://chameleon-llm.github.io., Comment: 32 pages, 10 figures, 24 tables. Accepted to NeurIPS 2023
- Published
- 2023
221. Pre-training Transformers for Knowledge Graph Completion
- Author
-
Chen, Sanxing, Cheng, Hao, Liu, Xiaodong, Jiao, Jian, Ji, Yangfeng, and Gao, Jianfeng
- Subjects
Computer Science - Computation and Language ,Computer Science - Machine Learning - Abstract
Learning transferable representation of knowledge graphs (KGs) is challenging due to the heterogeneous, multi-relational nature of graph structures. Inspired by Transformer-based pretrained language models' success on learning transferable representation for texts, we introduce a novel inductive KG representation model (iHT) for KG completion by large-scale pre-training. iHT consists of a entity encoder (e.g., BERT) and a neighbor-aware relational scoring function both parameterized by Transformers. We first pre-train iHT on a large KG dataset, Wikidata5M. Our approach achieves new state-of-the-art results on matched evaluations, with a relative improvement of more than 25% in mean reciprocal rank over previous SOTA models. When further fine-tuned on smaller KGs with either entity and relational shifts, pre-trained iHT representations are shown to be transferable, significantly improving the performance on FB15K-237 and WN18RR.
- Published
- 2023
222. Learning Fractals by Gradient Descent
- Author
-
Tu, Cheng-Hao, Chen, Hong-You, Carlyn, David, and Chao, Wei-Lun
- Subjects
Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Machine Learning - Abstract
Fractals are geometric shapes that can display complex and self-similar patterns found in nature (e.g., clouds and plants). Recent works in visual recognition have leveraged this property to create random fractal images for model pre-training. In this paper, we study the inverse problem -- given a target image (not necessarily a fractal), we aim to generate a fractal image that looks like it. We propose a novel approach that learns the parameters underlying a fractal image via gradient descent. We show that our approach can find fractal parameters of high visual quality and be compatible with different loss functions, opening up several potentials, e.g., learning fractals for downstream tasks, scientific understanding, etc., Comment: Accepted by AAAI 2023
- Published
- 2023
223. Global, regional, and national burden and trends of migraine among youths and young adults aged 15–39 years from 1990 to 2021: findings from the global burden of disease study 2021
- Author
-
Zhi-feng Chen, Xiang-meng Kong, Cheng-hao Yang, Xin-yu Li, Hong Guo, and Zhao-wei Wang
- Subjects
Migraine ,Global burden of disease ,Disability-adjusted life years ,Socio-demographic index ,Medicine - Abstract
Abstract Background Migraine, a widespread neurological condition, substantially affects the quality of life, particularly for adolescents and young adults. While its impact is significant, there remains a paucity of comprehensive global research on the burden of migraine in younger demographics. Our study sought to elucidate the global prevalence, incidence, and disability-adjusted life-years (DALYs) associated with migraine in the 15–39 age group from 1990 to 2021, utilizing data from the Global Burden of Disease (GBD) 2021 study. Methods Our comprehensive study analyzed migraine data from the GBD 2021 report, examining the prevalence, incidence, and DALYs across 204 countries and territories over a 32-year span. We stratified the information by age, sex, year, geographical region, and Socio-demographic Index (SDI). To evaluate temporal trends in these metrics, we employed the estimated annual percentage change (EAPC) calculation. Results Between 1990 and 2021, the worldwide prevalence of migraine among 15–39 year-olds increased substantially. By 2021, an estimated 593.8 million cases were reported, representing a 39.52% rise from 425.6 million cases in 1990. Global trends showed increases in age-standardized prevalence rate, incidence rate, and DALY rate for migraine during this period. The EAPC were positive for all three metrics: 0.09 for ASPR, 0.03 for ASIR, and 0.09 for DALY rate. Regions with medium SDI reported the highest absolute numbers of prevalent cases, incident cases, and DALYs in 2021. However, high SDI regions demonstrated the most elevated rates overall. Across the globe, migraine prevalence peaked in the 35–39 age group. Notably, female rates consistently exceeded male rates across all age categories. Conclusion The global impact of migraine on youths and young adults has grown considerably from 1990 to 2021, revealing notable variations across SDI regions, countries, age groups, and sexes. This escalating burden necessitates targeted interventions and public health initiatives, especially in areas and populations disproportionately affected by migraine.
- Published
- 2024
- Full Text
- View/download PDF
224. Global, regional, national epidemiology and trends of neglected tropical diseases in youths and young adults aged 15–39 years from 1990 to 2019: findings from the global burden of disease study 2019
- Author
-
Jia-jie Lv, Yi-chi Zhang, Xin-yu Li, Cheng-hao Yang, and Xuhui Wang
- Subjects
Global burden of disease ,Neglected tropical diseases ,Disability-adjusted life years ,Global Burden of Disease ,Social development index ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background In recent years, the escalating concern for neglected tropical diseases (NTDs) has been recognized as a pressing global health issue. This concern is acutely manifested in low- and middle-income countries, where there is an escalating prevalence among adolescents and young adults. The burgeoning of these conditions threatens to impair patients' occupational capabilities and overall life quality. Despite the considerable global impact of NTDs, comprehensive studies focusing on their impact in younger populations remain scarce. Our study aims to describe the global prevalence of neglected tropical diseases among people aged 15 to 39 years over the 30-year period from 1990 to 2019, and to project the disease burden of the disease up to 2040. Methods Annual data on incident cases, mortality, and disability-adjusted life years (DALYs) for NTDs were procured from the Global Burden of Disease Study 2019 (GBD 2019). These data were stratified by global and regional distribution, country, social development index (SDI), age, and sex. We computed age-standardized rates (ASRs) and the numbers of incident cases, mortalities, and DALYs from 1990 to 2019. The estimated annual percentage change (EAPC) in the ASRs was calculated to evaluate evolving trends. Results In 2019, it was estimated that there were approximately 552 million NTD cases globally (95% Uncertainty Interval [UI]: 519.9 million to 586.3 million), a 29% decrease since 1990. South Asia reported the highest NTD prevalence, with an estimated 171.7 million cases (95% UI: 150.4 million to 198.6 million). Among the five SDI categories, the prevalence of NTDs was highest in the moderate and low SDI regions in 1990 (approximately 270.5 million cases) and 2019 (approximately 176.5 million cases). Sub-Saharan Africa recorded the most significant decline in NTD cases over the past three decades. Overall, there was a significant inverse correlation between the disease burden of NTDs and SDI. Conclusion NTDs imposed over half a billion incident cases and 10.8 million DALYs lost globally in 2019—exerting an immense toll rivaling major infectious and non-communicable diseases. Encouraging declines in prevalence and disability burdens over the past three decades spotlight the potential to accelerate progress through evidence-based allocation of resources. Such strategic integration could substantially enhance public awareness about risk factors and available treatment options.
- Published
- 2024
- Full Text
- View/download PDF
225. Grain and chaff separation detection method based on machine vision
- Author
-
LI Xin, QI Jiamin, CHENG Hao, and WANG Yanchun
- Subjects
grain and chaff separation ,machine vision ,image processing ,feature extraction ,Food processing and manufacture ,TP368-456 - Abstract
[Objective] To solve the problem of poor manual detection accuracy of traditional grain and chaff separator and improve production efficiency. [Methods] An image detection method based on machine vision was proposed, which realized the feature recognition and separation of grain rough through multi-stage progressive fusion of different image algorithms. The acquired images were selected in the ROI region and enhanced by Retinex algorithm. The Otsu algorithm was used to segment the image, and then the median filtering wwas combined with morphology to remove the image noise. The improved Canny algorithm was used to detect edge features of binary images, and the position information of the contour of the valley rough image was extracted by combining the Hough transform. Finally, the state estimation of the position information was performed by using the Kalman filter, and the best predicted value of the separated position was obtained, while the position offset error was reduced. [Results] The average detection error of the system was 3.14 mm, a decrease of 1.82 mm compared to before filtering, and the average standard deviation of filtering error was 0.8 mm. [Conclusion] This method can effectively detect the grain rough feature information and improve the separation accuracy.
- Published
- 2024
- Full Text
- View/download PDF
226. The burden of non-alcoholic fatty liver disease among working-age people in the Western Pacific Region, 1990–2019: an age–period–cohort analysis of the Global Burden of Disease study
- Author
-
Jia-jie Lv, Yi-chi Zhang, Xin-yu Li, Hong Guo, and Cheng-hao Yang
- Subjects
Global burden of disease ,Non-alcoholic fatty liver disease ,Disability-adjusted life years ,Age-period-cohort analysis ,Trend analysis ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background The growing prevalence of non-alcoholic fatty liver disease (NAFLD) in younger populations, particularly those of working age (15–64 years), has become a public health concern. Being diagnosed at a younger age implies a greater likelihood of accruing disability-adjusted life years (DALYs) later in life due to potential progression to conditions such as cirrhosis or hepatocellular carcinoma. This study aims to analyze NAFLD prevalence trends over three decades globally, regionally, and nationally, with a focus on age, period, and birth cohort associations. Methods Global, regional, and country time trends in the prevalence of NAFLD among working-age people from 1990 to 2019: Age-period-cohort analysis based on Global Burden of Disease Study 2019 estimates and 95% uncertainty interval (UI) of NAFLD prevalence in the working age population was extracted from the Global Burden of Diseases, Injuries and Risk Factors Study 2019. Age-period-cohort models were used to estimate the prevalence within each age group from 1990 to 2019 (local drift, % per year), fitted longitudinal age-specific rates adjusted for period bias (age effect), and period/cohort relative risk (period/cohort effect). Results The global age-standardized prevalence (ASPR) of NAFLD increased significantly from 1990 (14,477.6 per 100 000) to 2019 (19,837.6 per 100 000). In the Western Pacific, there were 42,903.8 NAFLD cases in 2019, 54.15% higher than in 1990. The ASPR also increased significantly in the region over the past three decades. At the national level, Palau had the highest ASPR while Brunei Darussalam had the lowest. Age-period-cohort analysis showed that in the Western Pacific, unlike globally, the risk of NAFLD declined after age 60–64 years. Relative to 1980–1989, incidence and DALY risks decreased but prevalence increased in subsequent birth cohorts. Future predictions indicate an upward trend in NAFLD burden, especially among women and medium (SDI) regions like China. Conclusion Non-alcoholic fatty liver disease imparts an immense health burden that continues to grow globally and in the Asia Pacific region. Our work highlights working age adults as an at-risk group and calls attention to socioeconomic gradients within Western Pacific countries. Upward future projections demonstrate that NAFLD prevention is an urgent priority.
- Published
- 2024
- Full Text
- View/download PDF
227. Establishment of Typical Operating Conditions for Train Traction System Based on Short Trip Analysis Method
- Author
-
LU Xiulong, GUO Yidan, CHENG Hao, DENG Ming, and ZOU Xiaoyang
- Subjects
traction system ,energy efficiency ,typical operating conditions ,short trip analysis method ,nonparametric test ,Control engineering systems. Automatic machinery (General) ,TJ212-225 ,Technology - Abstract
This paper presents a method to establish typical operating conditions for train traction systems by combining site-based short trip analysis with nonparametric tests, in order to overcome various obstacles, such as inadequate efficiency testing results based on rated points of train traction systems, which often fail to accurately reflect the actual energy efficiency level of systems during long-distance operation under multiple conditions, and the existing absence of typical operating conditions essential for supporting the evaluation of traction systems' energy efficiency levels and guiding the energy-saving design of products. First, short trips were categorized, screened and randomly combined. Then, the optimal short-trip combination was identified through nonparametric tests. Subsequently, the typical operating conditions were developed, taking the traction system of an electric locomotive model as a case study. Furthermore, the proposed method was verified by analyzing errors in operating characteristic parameters and assessing the similarities in velocity-force (V-F) distribution probability two-dimensional matrix. The verification results revealed a deviation between the constructed typical operating conditions and the characteristic values derived from sampled data at 4.54%, and the consistency in V-F distribution probabilities at 98.06%. These findings indicate that the method proposed in this paper accurately reflects the actual operating characteristics of train traction systems, with the established typical operating conditions closely aligning with the actual operating conditions of train traction systems, underscoring their potential for aiding in energy-saving design and energy efficiency evaluation for train traction systems.
- Published
- 2024
- Full Text
- View/download PDF
228. SERS biosensors based on catalytic hairpin self-assembly and hybridization chain reaction cascade signal amplification strategies for ultrasensitive microRNA-21 detection
- Author
-
Chen, Qiying, Cao, Jinru, Kong, Hongxing, Chen, Ruijue, Wang, Ying, Zhou, Pei, Huang, Wenyi, Cheng, Hao, Li, Lijun, Gao, Si, and Feng, Jun
- Published
- 2024
- Full Text
- View/download PDF
229. Graphene oxide-templated biomineralization nanosystem enables multi-drug loading and controllable release
- Author
-
Fan, Zhechen, Chen, Yishan, Li, Qian, Gadora, Khalid, Ji, Zhongsheng, Wu, Dong, Zhou, Jianping, Ding, Yang, and Cheng, Hao
- Published
- 2024
- Full Text
- View/download PDF
230. LAformer: Trajectory Prediction for Autonomous Driving with Lane-Aware Scene Constraints
- Author
-
Liu, Mengmeng, Cheng, Hao, Chen, Lin, Broszio, Hellward, Li, Jiangtao, Zhao, Runjiang, Sester, Monika, and Yang, Michael Ying
- Subjects
Computer Science - Computer Vision and Pattern Recognition - Abstract
Trajectory prediction for autonomous driving must continuously reason the motion stochasticity of road agents and comply with scene constraints. Existing methods typically rely on one-stage trajectory prediction models, which condition future trajectories on observed trajectories combined with fused scene information. However, they often struggle with complex scene constraints, such as those encountered at intersections. To this end, we present a novel method, called LAformer. It uses a temporally dense lane-aware estimation module to select only the top highly potential lane segments in an HD map, which effectively and continuously aligns motion dynamics with scene information, reducing the representation requirements for the subsequent attention-based decoder by filtering out irrelevant lane segments. Additionally, unlike one-stage prediction models, LAformer utilizes predictions from the first stage as anchor trajectories and adds a second-stage motion refinement module to further explore temporal consistency across the complete time horizon. Extensive experiments on Argoverse 1 and nuScenes demonstrate that LAformer achieves excellent performance for multimodal trajectory prediction.
- Published
- 2023
231. Check Your Facts and Try Again: Improving Large Language Models with External Knowledge and Automated Feedback
- Author
-
Peng, Baolin, Galley, Michel, He, Pengcheng, Cheng, Hao, Xie, Yujia, Hu, Yu, Huang, Qiuyuan, Liden, Lars, Yu, Zhou, Chen, Weizhu, and Gao, Jianfeng
- Subjects
Computer Science - Computation and Language ,Computer Science - Artificial Intelligence - Abstract
Large language models (LLMs), such as ChatGPT, are able to generate human-like, fluent responses for many downstream tasks, e.g., task-oriented dialog and question answering. However, applying LLMs to real-world, mission-critical applications remains challenging mainly due to their tendency to generate hallucinations and their inability to use external knowledge. This paper proposes a LLM-Augmenter system, which augments a black-box LLM with a set of plug-and-play modules. Our system makes the LLM generate responses grounded in external knowledge, e.g., stored in task-specific databases. It also iteratively revises LLM prompts to improve model responses using feedback generated by utility functions, e.g., the factuality score of a LLM-generated response. The effectiveness of LLM-Augmenter is empirically validated on two types of scenarios, task-oriented dialog and open-domain question answering. LLM-Augmenter significantly reduces ChatGPT's hallucinations without sacrificing the fluency and informativeness of its responses. We make the source code and models publicly available., Comment: 15 pages
- Published
- 2023
232. Flexoelectricity-stabilized ferroelectric phase with enhanced reliability in ultrathin La:HfO2 films
- Author
-
Jiao, Peijie, Cheng, Hao, Li, Jiayi, Chen, Hongying, Liu, Zhiyu, Xi, Zhongnan, Ding, Wenjuan, Ma, Xingyue, Wang, Jian, Zheng, Ningchong, Nie, Yuefeng, Deng, Yu, Bellaiche, Laurent, Yang, Yurong, and Wu, Di
- Subjects
Condensed Matter - Materials Science - Abstract
Doped HfO2 thin films exhibit robust ferroelectric properties even for nanometric thicknesses, are compatible with current Si technology and thus have great potential for the revival of integrated ferroelectrics. Phase control and reliability are core issues for their applications. Here we show that, in (111)-oriented 5%La:HfO2 (HLO) epitaxial thin films deposited on (La0.3Sr0.7)(Al0.65Ta0.35)O3 substrates, the flexoelectric effect, arising from the strain gradient along the films normal, induces a rhombohedral distortion in the otherwise Pca21 orthorhombic structure. Density functional calculations reveal that the distorted structure is indeed more stable than the pure Pca21 structure, when applying an electric field mimicking the flexoelectric field. This rhombohedral distortion greatly improves the fatigue endurance of HLO thin films by further stabilizing the metastable ferroelectric phase against the transition to the thermodynamically stable non-polar monoclinic phase during repetitive cycling. Our results demonstrate that the flexoelectric effect, though negligibly weak in bulk, is crucial to optimize the structure and properties of doped HfO2 thin films with nanometric thicknesses for integrated ferroelectric applications.
- Published
- 2023
- Full Text
- View/download PDF
233. ForceFormer: Exploring Social Force and Transformer for Pedestrian Trajectory Prediction
- Author
-
Zhang, Weicheng, Cheng, Hao, Johora, Fatema T., and Sester, Monika
- Subjects
Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Multiagent Systems ,Computer Science - Robotics - Abstract
Predicting trajectories of pedestrians based on goal information in highly interactive scenes is a crucial step toward Intelligent Transportation Systems and Autonomous Driving. The challenges of this task come from two key sources: (1) complex social interactions in high pedestrian density scenarios and (2) limited utilization of goal information to effectively associate with past motion information. To address these difficulties, we integrate social forces into a Transformer-based stochastic generative model backbone and propose a new goal-based trajectory predictor called ForceFormer. Differentiating from most prior works that simply use the destination position as an input feature, we leverage the driving force from the destination to efficiently simulate the guidance of a target on a pedestrian. Additionally, repulsive forces are used as another input feature to describe the avoidance action among neighboring pedestrians. Extensive experiments show that our proposed method achieves on-par performance measured by distance errors with the state-of-the-art models but evidently decreases collisions, especially in dense pedestrian scenarios on widely used pedestrian datasets.
- Published
- 2023
234. Generating Evidential BEV Maps in Continuous Driving Space
- Author
-
Yuan, Yunshuang, Cheng, Hao, Yang, Michael Ying, and Sester, Monika
- Subjects
Computer Science - Computer Vision and Pattern Recognition - Abstract
Safety is critical for autonomous driving, and one aspect of improving safety is to accurately capture the uncertainties of the perception system, especially knowing the unknown. Different from only providing deterministic or probabilistic results, e.g., probabilistic object detection, that only provide partial information for the perception scenario, we propose a complete probabilistic model named GevBEV. It interprets the 2D driving space as a probabilistic Bird's Eye View (BEV) map with point-based spatial Gaussian distributions, from which one can draw evidence as the parameters for the categorical Dirichlet distribution of any new sample point in the continuous driving space. The experimental results show that GevBEV not only provides more reliable uncertainty quantification but also outperforms the previous works on the benchmarks OPV2V and V2V4Real of BEV map interpretation for cooperative perception in simulated and real-world driving scenarios, respectively. A critical factor in cooperative perception is the data transmission size through the communication channels. GevBEV helps reduce communication overhead by selecting only the most important information to share from the learned uncertainty, reducing the average information communicated by 87% with only a slight performance drop. Our code is published at https://github.com/YuanYunshuang/GevBEV.
- Published
- 2023
- Full Text
- View/download PDF
235. ShadowFormer: Global Context Helps Image Shadow Removal
- Author
-
Guo, Lanqing, Huang, Siyu, Liu, Ding, Cheng, Hao, and Wen, Bihan
- Subjects
Computer Science - Computer Vision and Pattern Recognition - Abstract
Recent deep learning methods have achieved promising results in image shadow removal. However, most of the existing approaches focus on working locally within shadow and non-shadow regions, resulting in severe artifacts around the shadow boundaries as well as inconsistent illumination between shadow and non-shadow regions. It is still challenging for the deep shadow removal model to exploit the global contextual correlation between shadow and non-shadow regions. In this work, we first propose a Retinex-based shadow model, from which we derive a novel transformer-based network, dubbed ShandowFormer, to exploit non-shadow regions to help shadow region restoration. A multi-scale channel attention framework is employed to hierarchically capture the global information. Based on that, we propose a Shadow-Interaction Module (SIM) with Shadow-Interaction Attention (SIA) in the bottleneck stage to effectively model the context correlation between shadow and non-shadow regions. We conduct extensive experiments on three popular public datasets, including ISTD, ISTD+, and SRD, to evaluate the proposed method. Our method achieves state-of-the-art performance by using up to 150X fewer model parameters., Comment: Accepted by AAAI2023
- Published
- 2023
236. GFlowNets for AI-Driven Scientific Discovery
- Author
-
Jain, Moksh, Deleu, Tristan, Hartford, Jason, Liu, Cheng-Hao, Hernandez-Garcia, Alex, and Bengio, Yoshua
- Subjects
Computer Science - Machine Learning - Abstract
Tackling the most pressing problems for humanity, such as the climate crisis and the threat of global pandemics, requires accelerating the pace of scientific discovery. While science has traditionally relied on trial and error and even serendipity to a large extent, the last few decades have seen a surge of data-driven scientific discoveries. However, in order to truly leverage large-scale data sets and high-throughput experimental setups, machine learning methods will need to be further improved and better integrated in the scientific discovery pipeline. A key challenge for current machine learning methods in this context is the efficient exploration of very large search spaces, which requires techniques for estimating reducible (epistemic) uncertainty and generating sets of diverse and informative experiments to perform. This motivated a new probabilistic machine learning framework called GFlowNets, which can be applied in the modeling, hypotheses generation and experimental design stages of the experimental science loop. GFlowNets learn to sample from a distribution given indirectly by a reward function corresponding to an unnormalized probability, which enables sampling diverse, high-reward candidates. GFlowNets can also be used to form efficient and amortized Bayesian posterior estimators for causal models conditioned on the already acquired experimental data. Having such posterior models can then provide estimators of epistemic uncertainty and information gain that can drive an experimental design policy. Altogether, here we will argue that GFlowNets can become a valuable tool for AI-driven scientific discovery, especially in scenarios of very large candidate spaces where we have access to cheap but inaccurate measurements or to expensive but accurate measurements. This is a common setting in the context of drug and material discovery, which we use as examples throughout the paper., Comment: 31 pages, 5 figures. Updated with camera-ready changes
- Published
- 2023
- Full Text
- View/download PDF
237. SupeRGB-D: Zero-shot Instance Segmentation in Cluttered Indoor Environments
- Author
-
Örnek, Evin Pınar, Krishnan, Aravindhan K, Gayaka, Shreekant, Kuo, Cheng-Hao, Sen, Arnie, Navab, Nassir, and Tombari, Federico
- Subjects
Computer Science - Computer Vision and Pattern Recognition - Abstract
Object instance segmentation is a key challenge for indoor robots navigating cluttered environments with many small objects. Limitations in 3D sensing capabilities often make it difficult to detect every possible object. While deep learning approaches may be effective for this problem, manually annotating 3D data for supervised learning is time-consuming. In this work, we explore zero-shot instance segmentation (ZSIS) from RGB-D data to identify unseen objects in a semantic category-agnostic manner. We introduce a zero-shot split for Tabletop Objects Dataset (TOD-Z) to enable this study and present a method that uses annotated objects to learn the ``objectness'' of pixels and generalize to unseen object categories in cluttered indoor environments. Our method, SupeRGB-D, groups pixels into small patches based on geometric cues and learns to merge the patches in a deep agglomerative clustering fashion. SupeRGB-D outperforms existing baselines on unseen objects while achieving similar performance on seen objects. We further show competitive results on the real dataset OCID. With its lightweight design (0.4 MB memory requirement), our method is extremely suitable for mobile and robotic applications. Additional DINO features can increase performance with a higher memory requirement. The dataset split and code are available at https://github.com/evinpinar/supergb-d., Comment: Accepted in Robotics and Automation Letters April 2023
- Published
- 2022
238. Language Models as Inductive Reasoners
- Author
-
Yang, Zonglin, Dong, Li, Du, Xinya, Cheng, Hao, Cambria, Erik, Liu, Xiaodong, Gao, Jianfeng, and Wei, Furu
- Subjects
Computer Science - Computation and Language ,Computer Science - Artificial Intelligence - Abstract
Inductive reasoning is a core component of human intelligence. In the past research of inductive reasoning within computer science, formal language is used as representations of knowledge (facts and rules, more specifically). However, formal language can cause systematic problems for inductive reasoning such as disability of handling raw input such as natural language, sensitiveness to mislabeled data, and incapacity to handle ambiguous input. To this end, we propose a new paradigm (task) for inductive reasoning, which is to induce natural language rules from natural language facts, and create a dataset termed DEER containing 1.2k rule-fact pairs for the task, where rules and facts are written in natural language. New automatic metrics are also proposed and analysed for the evaluation of this task. With DEER, we investigate a modern approach for inductive reasoning where we use natural language as representation for knowledge instead of formal language and use pretrained language models as ''reasoners''. Moreover, we provide the first and comprehensive analysis of how well pretrained language models can induce natural language rules from natural language facts. We also propose a new framework drawing insights from philosophy literature for this task, which we show in the experiment section that surpasses baselines in both automatic and human evaluations. We discuss about our future perspectives for inductive reasoning in Section 7. Dataset and code are available at https://github.com/ZonglinY/Inductive_Reasoning., Comment: Accepted by EACL 2024
- Published
- 2022
239. Visual Query Tuning: Towards Effective Usage of Intermediate Representations for Parameter and Memory Efficient Transfer Learning
- Author
-
Tu, Cheng-Hao, Mai, Zheda, and Chao, Wei-Lun
- Subjects
Computer Science - Machine Learning ,Computer Science - Artificial Intelligence ,Computer Science - Computer Vision and Pattern Recognition - Abstract
Intermediate features of a pre-trained model have been shown informative for making accurate predictions on downstream tasks, even if the model backbone is kept frozen. The key challenge is how to utilize these intermediate features given their gigantic amount. We propose visual query tuning (VQT), a simple yet effective approach to aggregate intermediate features of Vision Transformers. Through introducing a handful of learnable ``query'' tokens to each layer, VQT leverages the inner workings of Transformers to ``summarize'' rich intermediate features of each layer, which can then be used to train the prediction heads of downstream tasks. As VQT keeps the intermediate features intact and only learns to combine them, it enjoys memory efficiency in training, compared to many other parameter-efficient fine-tuning approaches that learn to adapt features and need back-propagation through the entire backbone. This also suggests the complementary role between VQT and those approaches in transfer learning. Empirically, VQT consistently surpasses the state-of-the-art approach that utilizes intermediate features for transfer learning and outperforms full fine-tuning in many cases. Compared to parameter-efficient approaches that adapt features, VQT achieves much higher accuracy under memory constraints. Most importantly, VQT is compatible with these approaches to attain even higher accuracy, making it a simple add-on to further boost transfer learning., Comment: Accepted by CVPR 2023. Cheng-Hao Tu and Zheda Mai contributed equally to this work
- Published
- 2022
240. Analysis of the Abasic Sites in Breast Cancer Patients With 5 Year Postoperative Treatment Without Recurrence in Taiwan
- Author
-
Che Lin MD-PhD, Chi-Yen Feng MD, Gilang P. Bahari MS, Sheng-Min Huang PhD, Cheng-Hao Wei MS, Qi Xu MS, Dat Thanh Dinh PhD, Dar-Ren Chen MD, and Po-Hsiung Lin PhD
- Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Purpose This prospective study aimed to investigate estrogen-induced carcinogenesis by assessing the background levels of abasic sites (apurinic/apyrimidinic sites, AP sites) in Taiwanese breast cancer patients following 5 years of postoperative treatment without recurrence (5-year survivors) (n = 70). The study also sought to compare the extent of these DNA lesions with those found in healthy controls and in breast cancer patients prior to treatment. Methods Abasic sites were measured using an aldehyde reactive probe and quantified as the total number of abasic sites per total nucleotides. Characterization of the abasic sites in subjects recruited for this study was conducted using the abasic site cleavage assay using putrescine or T7 exonuclease (T7 Exo) and/or exonuclease III (Exo III). Results The number of abasic sites detected in 5 year survivors (26.7 ± 10.2 per 10 6 total nucleotides, n = 70) was significantly reduced by 46.9% compared to those in breast cancer patients before treatment (50.3 ± 59.2 per 10 6 total nucleotides, P < 0.001), and was similar to the levels observed in healthy controls (23.3 ± 13.5 per 10 6 total nucleotides, P > 0.05). Further investigation into the specific types of abasic sites indicated that the number of abasic sites excisable by putrescine in controls, breast cancer patients, and 5-year survivors were 63.3%, 78.6%, and 67.7%, respectively. These findings suggest the involvement of oxidative stress rather than depurination/depyrimidination of DNA adducts in the formation of abasic sites. Further analyses were performed using exonuclease cleavage assay to characterize the specific types of abasic sites including 5′-cleaved, 3′-cleaved, intact, and residual abasic sites. Results demonstrated that the proportion of residual abasic sites detected in controls, breast cancer patients, and 5-year survivors were estimated to be 32.7%, 48.8%, and 34.0%, respectively. Conclusion Overall, these findings suggest clear evidence of treatment-related effects on the reduction of levels of abasic sites as well as on the profile of abasic sites in 5 year survivors.
- Published
- 2024
- Full Text
- View/download PDF
241. Immunoediting in acute myeloid leukemia: Reappraising T cell exhaustion and the aberrant antigen processing machinery in leukemogenesis
- Author
-
Ching-Yun Wang, Shiuan-Chen Lin, Kao-Jung Chang, Han-Ping Cheong, Sin-Rong Wu, Cheng-Hao Lee, Ming-Wei Chuang, Shih-Hwa Chiou, Chih-Hung Hsu, and Po-Shen Ko
- Subjects
Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
Acute myeloid leukemia (AML) establishes an immunosuppressive microenvironment that favors leukemic proliferation. The immune-suppressive cytokines altered antigen processing, and presentation collectively assist AML cells in escaping cytotoxic T-cell surveillance. These CD8+ T cell dysfunction features are emerging therapeutic targets in relapsed/refractory AML patients. Besides, CD8+ T cell exhaustion is a hotspot in recent clinical oncology studies, but its pathophysiology has yet to be elucidated in AML. In this review, we summarize high-quality original studies encompassing the phenotypic and genomic characteristics of T cell exhaustion events in the leukemia progression, emphasize the surface immuno-peptidome that dynamically tunes the fate of T cells to function or dysfunction states, and revisit the biochemical and biophysical properties of type 1 MHC antigen processing mechanism (APM) that pivots in the phenomenon of leukemia antigen dampening.
- Published
- 2024
- Full Text
- View/download PDF
242. Interferon-alpha and MxA inhibit BK polyomavirus replication by interaction with polyomavirus large T antigen
- Author
-
Hsin-Hsu Wu, Yi-Jung Li, Cheng-Hao Weng, Hsiang-Hao Hsu, Ming-Yang Chang, Huang-Yu Yang, Chih-Wei Yang, and Ya-Chung Tian
- Subjects
BK polyomavirus ,Kidney transplant ,Interferon ,MxA ,Medicine (General) ,R5-920 ,Biology (General) ,QH301-705.5 - Abstract
Introduction: BK Polyomavirus (BKPyV) infection is a common complication in kidney transplant recipients and can result in poor outcomes and graft failure. Currently, there is no known effective antiviral agent. This study investigated the possible antiviral effects of Interferon alpha (IFNα) and its induced protein, MxA, against BKPyV. Methods: In vitro cell culture experiments were conducted using human primary renal proximal tubular epithelial cells (HRPTECs). We also did animal studies using Balb/c mice with unilateral kidney ischemic reperfusion injury. Results: Our results demonstrated that IFNα effectively inhibited BKPyV in vitro and murine polyomavirus in animal models. Additionally, IFNα and MxA were found to suppress BKPyV TAg and VP1 production. Silencing MxA attenuated the antiviral efficacy of IFNα. We observed that MxA interacted with BKPyV TAg, causing it to remain in the cytosol and preventing its nuclear translocation. To determine MxA's essential domain for its antiviral activities, different mutant MxA constructs were generated. The MxA mutant K83A retained its interaction with BKPyV TAg, and its antiviral effects were intact. The MxA T103A mutant, on the other hand, abolished GTPase activity, lost its protein-protein interaction with BKPyV TAg, and lost its antiviral effect. Conclusion: IFNα and its downstream protein, MxA, have potent antiviral properties against BKPyV. Furthermore, our findings indicate that the interaction between MxA and BKVPyV TAg plays a crucial role in determining the anti-BKPyV effects of MxA.
- Published
- 2024
- Full Text
- View/download PDF
243. Brain imaging traits and epilepsy: Unraveling causal links via mendelian randomization
- Author
-
Fangyan Li, Maowen Tang, Cheng Hao, Menghua Yang, Yue Pan, and Pinggui Lei
- Subjects
epilepsy ,imaging‐derived phenotypes ,magnetic resonance imaging ,Mendelian randomization ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Abstract Background Epilepsy, a complex neurological disorder, is closely linked with structural and functional irregularities in the brain. However, the causal relationship between brain imaging‐derived phenotypes (IDPs) and epilepsy remains unclear. This study aimed to investigate this relationship by employing a two‐sample bidirectional Mendelian randomization (MR) approach. Methods The analysis involved 3935 cerebral IDPs from the UK Biobank and all documented cases of epilepsy (all epilepsies) cohorts from the International League Against Epilepsy, with further validation through replication and meta‐analyses using epilepsy Genome‐Wide Association Studies datasets from the FinnGen database. Additionally, a multivariate MR analysis framework was utilized to assess the direct impact of IDPs on all epilepsies. Furthermore, we performed a bidirectional MR analysis to investigate the relationship between the IDPs identified in all epilepsies and the 15 specific subtypes of epilepsy. Results The study identified significant causal links between four IDPs and epilepsy risk. Decreased fractional anisotropy in the left inferior longitudinal fasciculus was associated with a higher risk of epilepsy (odds ratio [OR]: 0.89, p = 3.31×10−5). Conversely, increased mean L1 in the left posterior thalamic radiation (PTR) was independently associated with a heightened epilepsy risk (OR: 1.14, p = 4.72×10−5). Elevated L3 in the left cingulate gyrus was also linked to an increased risk (OR: 1.09, p = .03), while decreased intracellular volume fraction in the corpus callosum was correlated with higher epilepsy risk (OR: 0.94, p = 1.15×10−4). Subtype analysis revealed that three of these IDPs are primarily associated with focal epilepsy (FE). Notably, increased L1 in the left PTR was linked to an elevated risk of hippocampal sclerosis (HS) and lesion‐negative FE, whereas elevated L3 in the left cingulate gyrus was associated with HS‐related FE. Conclusions Our research offers genetic evidence for a causal link between brain IDPs and epilepsy. These results enhance our understanding of the structural brain changes associated with the onset and progression of epilepsy.
- Published
- 2024
- Full Text
- View/download PDF
244. The association between brominated flame retardants exposure with Parkinson’s disease in US adults: a cross-sectional study of the National Health and Nutrition Examination Survey 2009–2016
- Author
-
Jia-jie Lv, Yi-chi Zhang, Xin-yu Li, Lin-jie Zhang, Zhuo-ma Yixi, Cheng-hao Yang, and Xu-hui Wang
- Subjects
brominated flame retardants ,Parkinson’s disease ,The National Health and Nutrition Examination Survey ,cross-sectional study ,BKMR analysis ,Public aspects of medicine ,RA1-1270 - Abstract
BackgroundIncreasing evidence suggests that environmental factors play a crucial role in the pathogenesis of Parkinson’s disease (PD). Humans are simultaneously exposed to multiple brominated flame retardants (BFRs) in the environment. However, the relationship between BFRs and PD remains unclear. This study was designed to investigate the overall association between BFRs and PD in a nationally representative US population and to further identify significant chemicals.MethodsThis study used data from 7,161 NHANES participants from 2009 through 2016. The serum BFRs registry included PBDE-28, PBDE-47, PBDE-85, PBDE-99, PBDE-100, PBDE-153, PBDE-154, PBDE-183, PBDE-209, and PBB-153. A survey-weighted generalized logistic regression model with restricted cubic splines (RCS) was used to evaluate the association between single BFRs exposure and periodontitis. Meanwhile, weighted quantile sum (WQS) regression and Bayesian kernel machine regression (BKMR) were used to evaluate the overall association of mixed frankincense powder with periodontitis and to identify significant chemicals. Sensitivity analysis was performed to evaluate the robustness of the results.ResultsAmong the 7,161 participants, 65 had PD. PD patients were older (mean age 57.79 vs. 46.57 years) and had a higher proportion of females (70.86%) compared to non-PD participants. Serum levels of PBB-153 were significantly higher in those with PD. Logistic regression analyses revealed a non-linear, inverted U-shaped relationship between serum PBB-153 and PD risk. The risk of PD increased with higher PBB-153 levels up to the 3rd quartile (Q3), beyond which the risk declined (Q3 vs. Q1: OR = 4.98, 95% CI = 1.79–13.86; Q4 vs. Q1: OR = 3.23, 95% CI = 1.03–10.08). PBB-153 (43.40%), PBDE-153 (24.75%), and PBDE-85 (19.51%) contributed most to the weighted quantile sum index associated with PD risk. Bayesian kernel machine regression confirmed the inverted U-shaped dose–response pattern for PBB-153 and the overall BFR mixture. Restricted cubic spline analyses corroborated the non-linear relationship between PBB-153 and PD, which was more pronounced among women and those aged 37–58 years. Sensitivity analyses substantiated these findings.ConclusionThis nationally representative cross-sectional study revealed a novel non-linear, inverted U-shaped relationship between serum levels of the brominated flame retardant PBB-153 and Parkinson’s disease risk in U.S. adults. The risk increased with higher PBB-153 exposure up to a point, beyond which it declined. This complex dose–response pattern highlights the importance of considering potential hormetic mechanisms and effect modifiers when evaluating environmental exposures and neurodegenerative diseases. Further research is warranted to elucidate the underlying biological pathways and inform risk mitigation strategies.
- Published
- 2024
- Full Text
- View/download PDF
245. Spectrochip-based Calibration Curve Modeling (CCM) for Rapid and Accurate Multiple Analytes Quantification in Urinalysis
- Author
-
Cheng-Hao Ko, Ashenafi Belihu Tadesse, and Abel Chernet Kabiso
- Subjects
Characteristic Wavelength (λc) ,Calibration Curve Modeling (CCM) ,Micro-electromechanical System (MEMS) ,Point-of-Care (POC) Testing ,Spectrochip ,Urinalysis ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
Most urine test strips are intended to enable the general population to rapidly and easily diagnose potential renal disorders. It is semi-quantitative in nature, and although the procedure is straightforward, certain factors will affect the judgmental outcomes. This study describes rapid and accurate quantification of twelve urine test strip parameters: leukocytes, nitrite, urobilinogen, protein, pH, occult blood, specific gravity, ketone, bilirubin, glucose, microalbumin, and creatinine using a micro-electromechanical system (MEMS)-based spectrophotometer, known as a spectrochip. For each parameter, absorption spectra were measured three times independently at eight different concentration levels of diluted standard solutions, and the average spectral intensities were calculated to establish the calibration curve under the characteristic wavelength (λc). Then, regression analysis on the calibration curve was performed with GraphPad Prism software, which revealed that the coefficient of determination (R2) of the modeled calibration curves was greater than 0.95. This result illustrates that the measurements exceed standard levels, confirming the importance of a spectrochip for routine multi-parameter urine analysis. Thus, it is possible to obtain the spectral signal strength for each parameter at its characteristic wavelength in order to compare directly with the calibration curves in the future, even in situations when sample concentration is unknown. Additionally, the use of large testing machines can be reduced in terms of cost, time, and space by adopting a micro urine testing platform based on spectrochip, which also improves operational convenience and effectively enables point-of-care (POC) testing in urinalysis.
- Published
- 2024
- Full Text
- View/download PDF
246. Global, regional, and national burden of ischemic stroke, 1990–2021: an analysis of data from the global burden of disease study 2021Research in context
- Author
-
Xin-yu Li, Xiang-meng Kong, Cheng-hao Yang, Zhi-feng Cheng, Jia-jie Lv, Hong Guo, and Xiao-hong Liu
- Subjects
Ischemic stroke ,Global burden of disease ,Disability-adjusted life years ,Incidence ,Prevalence ,Medicine (General) ,R5-920 - Abstract
Summary: Background: Ischemic stroke remains a major contributor to global mortality and morbidity. This study aims to provide an updated assessment of rates in ischemic stroke prevalence, incidence, mortality, and disability-adjusted life-years (DALYs) from 1990 to 2021, specifically focusing on including prevalence investigation alongside other measures. The analysis is stratified by sex, age, and socio-demographic index (SDI) at global, regional, and national levels. Methods: Data for this study was obtained from the 2021 Global Burden of Diseases, Injuries, and Risk Factors Study (GBD). To quantify temporal patterns and assess trends in age-standardized rates of ischemic stroke prevalence (ASPR), incidence (ASIR), mortality (ASDR), and DALYs, estimated annual percentage changes (EAPCs) were computed over the study period. The analyses were disaggregated by gender, 20 age categories, 21 GBD regions, 204 nations/territories, and 5 SDI quintiles. R statistical package V 4.4.2 was performed for statistical analyses and plot illustrations. Findings: In 2021, the global burden of ischemic stroke remained substantial, with a total of 69,944,884.8 cases with an ASPR of 819.5 cases per 100,000 individuals (95% UI: 760.3–878.7). The ASIR was 92.4 per 100,000 people (95% UI: 79.8–105.8), while the ASDR was 44.2 per 100,000 persons (95% UI: 39.3–47.8). Additionally, the age-standardized DALY rate was 837.4 per 100,000 individuals (95% UI: 763.7–905). Regionally, areas with high-middle SDI exhibited the greatest ASPR, ASIR, ASDR, and age-standardized DALY rates, whereas high SDI regions had the lowest rates. Geospatially, Southern Sub-Saharan Africa had the highest ASPR, while Eastern Europe showed the highest ASIR. The greatest ASDR and age-standardized DALY rates were observed in Eastern Europe, Central Asia, as well as North Africa, and the Middle East. Among countries, Ghana had the highest ASPR, and North Macedonia had both the highest ASIR and ASDR. Furthermore, North Macedonia also exhibited the highest age-standardized DALY rate. Interpretation: Regions with high-middle and middle SDI continued to experience elevated ASPR, ASIR, ASDR and age-standardized DALY rates. The highest ischemic stroke burden was observed in Southern Sub-Saharan Africa, Central Asia, Eastern Europe, and the Middle East. Funding: None.
- Published
- 2024
- Full Text
- View/download PDF
247. Phenolics from the Leaves and Stems of Caesalpinia enneaphylla
- Author
-
Sun, Qiong-Hui, Yang, Shun-Yi, Yu, Li-Mei, Yan, Wen, Cheng, Hao, Liu, Bo, Aisa, Haji Akber, and Chen, Ye-Gao
- Published
- 2024
- Full Text
- View/download PDF
248. GDA: Generalized Diffusion for Robust Test-Time Adaptation.
- Author
-
Yun-Yun Tsai, Fu-Chen Chen, Albert Y. C. Chen, Junfeng Yang, Che-Chun Su, Min Sun, and Cheng-Hao Kuo
- Published
- 2024
- Full Text
- View/download PDF
249. No More Ambiguity in 360° Room Layout via Bi-Layout Estimation.
- Author
-
Yu-Ju Tsai, Jin-Cheng Jhang, Jingjing Zheng, Wei Wang, Albert Y. C. Chen, Min Sun 0001, Cheng-Hao Kuo, and Ming-Hsuan Yang 0001
- Published
- 2024
- Full Text
- View/download PDF
250. Code Generation Using Self-Interactive Assistant.
- Author
-
Zixiao Zhao, Jing Sun 0002, Cheng-Hao Cai, and Zhiyuan Wei
- Published
- 2024
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.