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204. The role of ethnic retailing in retrofitting suburbia: case studies from Toronto, Canada.

Author

Zhuang, Zhixi Cecilia and Chen, Amanda Xiaoxuan

Abstract

Today’s immigrants to Canada are increasingly and directly settling into suburban areas of major cities; a trend that has resulted in new retail opportunities: suburban ethnic shopping centres are a growing phenomenon in areas with major immigrant settlement. This paper discusses the development and retrofitting processes of three suburban Chinese shopping malls in the Toronto area. The paper explores how these malls successfully regenerated areas once affected by business decline and how they can act as a catalyst to develop a new urban form that makes the suburban landscape less uniform and more sustainable. Various perspectives from key players involved in ethnic retail activities and developments were collected, including surveys with entrepreneurs and shoppers, and semi-structured interviews with city councillors, city planners, developers and an architect. The paper suggests that municipalities could invest in established ethnic retail places as an innovative means of “retrofitting suburbia.” [ABSTRACT FROM PUBLISHER]

Published
2017
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206. Can You Name These Cities?

Author

Chen, Amanda

Subjects
CITIES & towns, PUBLIC transit
Abstract

(Bloomberg Businessweek) -- This story is part of Businessweek's Cities issue, a collaboration with CityLab. Here are data profiles of six distinctive global cities. More Highlights From the Cities Issue The Stuff of Cities A (Mostly) Empty $100 Billion City Rising From the Sea The Electric Vehicle That Suburbia Needs Could Be a Golf Cart Nigeria's Train to Nowhere Shows How Not to Build Public Transit Luxury Villas Are Going Up in a Palestinian Boomtown Built on Shaky Peace The Pandemic Transformed America's Biggest Downtowns in Very Different Ways ©2023 Bloomberg L.P. [Extracted from the article]

Published
2023

207. Test of variables of attention (TOVA) as a predictor of early attention complaints, an antecedent to dementia

Author

Braverman,Eric R, Chen,Amanda Lih-Chuan, Chen,Thomas JH, Schoolfield,John D, Notaro,Alison, Braverman,Dasha, Kerner,Mallory, Blum,Seth H, Arcuri,Vanessa, Varshavskiy,Michael, Damle,Uma, Downs,B William, Waite,Roger L, Berman,Marlene Oscar, Giordano,John, Blum,Kenneth, Braverman,Eric R, Chen,Amanda Lih-Chuan, Chen,Thomas JH, Schoolfield,John D, Notaro,Alison, Braverman,Dasha, Kerner,Mallory, Blum,Seth H, Arcuri,Vanessa, Varshavskiy,Michael, Damle,Uma, Downs,B William, Waite,Roger L, Berman,Marlene Oscar, Giordano,John, and Blum,Kenneth

Abstract

Eric R Braverman1,5, Amanda Lih-Chuan Chen2, Thomas JH Chen3, John D Schoolfield4, Alison Notaro5, Dasha Braverman5, Mallory Kerner5, Seth H Blum6 , Vanessa Arcuri5, Michael Varshavskiy5, Uma Damle5 , B William Downs7, Roger L Waite7, Marlene Oscar-Berman8, John Giordano9 , Kenneth Blum5,6,7,101Division of Neurological Surgery, Weill Cornell College of Medicine, New York, NY, USA; 2Department of Engineering and Management of Advanced Technology, 3Department of Occupational Safety and Health, Chang Jung Christian University, Tainan, Taiwan Republic of China; 4Department of Periodontics, University of Texas, Health Science Center, San Antonio, TX, USA; 5PATH Research Foundation, New York, NY, USA; 6Department of Nutritional Genomics, Synaptamine, Inc., San Antonio, TX, USA; 7Department of Personalized Medicine, LifeGen, Inc., La Jolla, CA, USA; 8Boston University School of Medicine, Boston VA, Boston, MA, USA; 9Department of Holistic Medicine, G & G Holistic Addiction Treatment Center, North Miami Beach, FL, USA; 10Department of Physiology and Pharmacology, University of Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC, USAAbstract: The goal of this study was to determine if impairments detected by the test of variables of attention (TOVA) may be used to predict early attention complaints and memory impairments accurately in a clinical setting. We performed a statistical analysis of outcomes in a patient population screened for attention deficit hyperactivity disorder or attention complaints, processing errors as measured by TOVA and the Wechsler Memory Scale (WMS-III) results. Attention deficit disorder (ADD) checklists, constructed using the Diagnostic and Statistical Manual of Mental Disorders 4th Edition criteria, which were completed by patients at PATH Medical, revealed that 72.8% of the patients had more than one attention complaint out of a total of 16 complaints, and 41.5% had more than five complaints. For the 128 males wit

Published
2010

208. First-Principles Investigations of Interfacial Dynamics in Nano-Materials

Author

Chen, Amanda Amy

Subjects
Chemical engineering
Abstract

Most scenarios in our daily life can be related to thermodynamic principles. The investigation of thermodynamic phenomena, including heat transfer, chemical reactions, and dynamics, are explored to develop various appliances that play a fundamental role in our current lives. Therefore, thermodynamics are the foundation of our modern life framework. However, it is impractical to “manually” put all thermodynamic theories together to predict the outcomes. Therefore, computer simulations have been developed to simulate those complicated models for practical applications. In this research study, we used computer simulations with core thermodynamic disciplines to resolve the challenges encountered in the industry and also the threat from climate change. With the lab collaboration, this work provided not only the theoretical consequences but also the experimental supports in practical uses. Along with the computational and experimental bases, we explored the fields on generating the appropriate forcefield models, investigating the materials characteristics inside the Metal-Organic frameworks, and analyzing the curvature-selective ligand adsorption toward nanoparticles. Considerations of larger systems applied in real life are a natural extension, and insights on the behavior of theoretical functions are being explored.

Published
2023

209. Attention-deficit-hyperactivity disorder and reward deficiency syndrome

Author

Blum,Kenneth, Chen,Amanda Lih-Chuan, Braverman,Eric R, Comings,David E, Chen,Thomas JH, Arcuri,Vanessa, Blum,Seth H, Downs,Bernard W, Waite,Roger L, Notaro,Alison, Lubar,Joel, Williams,Lonna, Prihoda,Thomas J, Palomo,Tomas, Oscar-Berman,Marlene, Blum,Kenneth, Chen,Amanda Lih-Chuan, Braverman,Eric R, Comings,David E, Chen,Thomas JH, Arcuri,Vanessa, Blum,Seth H, Downs,Bernard W, Waite,Roger L, Notaro,Alison, Lubar,Joel, Williams,Lonna, Prihoda,Thomas J, Palomo,Tomas, and Oscar-Berman,Marlene

Abstract

Kenneth Blum1,6,7,8,9,10, Amanda Lih-Chuan Chen2, Eric R Braverman3,9, David E Comings4, Thomas JH Chen5, Vanessa Arcuri9, Seth H Blum6, Bernard W Downs7,8, Roger L Waite7, Alison Notaro9, Joel Lubar10, Lonna Williams7, Thomas J Prihoda11, Tomas Palomo12, Marlene Oscar-Berman131Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, NC; 2Department of Engineering and Management of Advanced Technology, Chang Jung University, Tainan, Taiwan, Republic of China; 3Department of Neurosurgery, Weill College of Medicine, New York, NY; 4Department of Medical Genetics, City of Hope Medical Center, Duarte, CA; 5Department of Occupational Safety and Health, Chang Jung University, Tainan, Taiwan, Republic of China; 6Department of Psychoneurogenetics, Synapatamine, Inc., San Antonio, TX; 7LifeGen, Inc., La Jolla, CA; 8Allied Nutraceutical Research, Lederach, PA; 9PATH Research Foundation, New York, NY; 10Department of Physiology, University of Tennessee, Knoxville, TN; 11Department of Pathology, University of Texas Health Science Center, San Antonio, TX; 12Hospital Universitario 12 de Octubre, Madrid, Spain; 13Boston University School of Medicine, and Boston VA Healthcare System, Boston, MAParts of this manuscript have been published in Theor Biol Med Model (Comings et al 2005), which is an open access journalAbstract: Molecular genetic studies have identified several genes that may mediate susceptibility to attention deficit hyperactivity disorder (ADHD). A consensus of the literature suggests that when there is a dysfunction in the “brain reward cascade,” especially in the dopamine system, causing a low or hypo-dopaminergic trait, the brain may require dopamine for individuals to avoid unpleasant feelings. This high-risk genetic trait leads to multiple drug-seeking behaviors, because the drugs activate release of dopamine, which can diminish abnormal cravings. Moreover, this genetic trait is due in part to a form

Published
2008

213. Characterization of resistance to multiple fungicides in Botrytis cinerea populations from Asian ginseng in northeastern China.

Author

Lu, Xiao, Jiao, Xiao, Hao, Jianjun, Chen, Amanda, and Gao, Wei

Abstract

Botrytis cinerea infects ginseng throughout the whole growing season and results in significant economic losses. Fungicides have been the primary strategy in disease control, but frequent applications can increase the risk of fungicide resistance. To determine the resistance of field populations, 76 B. cinerea isolates were collected from 10 ginseng fields in Northeastern China in 2012 and 2013. The sensitivities of these isolates were examined to carbendazim, iprodione, pyrimethanil and azoxystrobin by analyzing mycelial growth inhibition. Almost all test isolates were resistant to at least one fungicide. For example, 27.6 %, 49.9 % and 21.1 % of the population was resistant to one, two or three of four test fungicides, respectively. There was only one isolate that was sensitive to all four fungicides. However, none were simultaneously resistant to all of the four fungicides. Mutations for E198A in the β-tubulin gene and G143A in the cyt b gene were found in all carbendazim- and azoxystrobin-resistant isolates, respectively, indicating a high level of resistance. Various mutations in the bos1 gene were associated with iprodione resistance, among which two combined point mutations, D757N and E369P, could be a novel genotype. Gene structure analysis showed that 50 % of the isolates carried the Bcbi143/144 intron in cyt b, indicating a high inherent risk for the development of G143A-associated resistance to quinone outside inhibitor fungicides. Most resistant isolates did not show reduced compound fitness in mycelial growth, sclerotial and conidial production, aggressiveness and sensitivity to osmotic stress. In conclusion, multi-fungicide resistance of B. cinerea contributed to the inefficiency of current fungicides. [ABSTRACT FROM AUTHOR]

Published
2016
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214. Early Intervention of Intravenous KB220IV- Neuroadaptagen Amino-Acid Therapy (NAAT)™ Improves Behavioral Outcomes in a Residential Addiction Treatment Program: A Pilot Study

Author

Miller, Merlene, primary, Chen, Amanda LC, additional, Stokes, Stan D., additional, Silverman, Susan, additional, Bowirrat, Abdalla, additional, Manka, Matthew, additional, Manka, Debra, additional, Miller, David K., additional, Perrine, Kenneth, additional, Chen, Thomas JH, additional, Bailey, John A., additional, Downs, William, additional, Waite, Roger L., additional, Madigan, Margaret A., additional, Braverman, Eric R., additional, Damle, Uma, additional, Kerner, Mallory, additional, Giordano, John, additional, Morse, Siobhan, additional, Oscar-Berman, Marlene, additional, Barh, Debmalya, additional, and Blum, Kenneth, additional

Published
2012
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218. The Addictive Brain: All Roads Lead to Dopamine

Author

Blum, Kenneth, primary, Chen, Amanda LC, additional, Giordano, John, additional, Borsten, Joan, additional, Chen, Thomas JH, additional, Hauser, Mary, additional, Simpatico, Thomas, additional, Femino, John, additional, Braverman, Eric R., additional, and Barh, Debmalya, additional

Published
2012
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221. Chronic Abstinence Symptom Severity Scale--Revised

Author

Miller, Merlene, primary, Chen, Amanda L. C., additional, Stokes, Stan D., additional, Silverman, Susan, additional, Bowirrat, Abdalla, additional, Manka, Matthew, additional, Manka, Debra, additional, Miller, David K., additional, Perrine, Kenneth, additional, Chen, Thomas J. H., additional, Bailey, John A., additional, Downs, William, additional, Waite, Roger L., additional, Madigan, Margaret A., additional, Braverman, Eric R., additional, Damle, Uma, additional, Kerner, Mallory, additional, Giordano, John, additional, Morse, Siobhan, additional, Oscar-Berman, Marlene, additional, Barh, Debmalya, additional, and Blum, Kenneth, additional

Published
2012
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223. Generational Association Studies of Dopaminergic Genes in Reward Deficiency Syndrome (RDS) Subjects: Selecting Appropriate Phenotypes for Reward Dependence Behaviors

Author

Blum, Kenneth, primary, Chen, Amanda L. C., additional, Oscar-Berman, Marlene, additional, Chen, Thomas J. H., additional, Lubar, Joel, additional, White, Nancy, additional, Lubar, Judith, additional, Bowirrat, Abdalla, additional, Braverman, Eric, additional, Schoolfield, John, additional, Waite, Roger L., additional, Downs, Bernard W., additional, Madigan, Margaret, additional, Comings, David E., additional, Davis, Caroline, additional, Kerner, Mallory M., additional, Knopf, Jennifer, additional, Palomo, Tomas, additional, Giordano, John J., additional, Morse, Siobhan A., additional, Fornari, Frank, additional, Barh, Debmalya, additional, Femino, John, additional, and Bailey, John A., additional

Published
2011
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225. Neurogenetics and Clinical Evidence for the Putative Activation of the Brain Reward Circuitry by a Neuroadaptagen: Proposing an Addiction Candidate Gene Panel Map

Author

Chen, Thomas J.H., primary, Blum, Kenneth, additional, Chen, Amanda L.C., additional, Bowirrat, Abdalla, additional, Downs, William B., additional, Madigan, Margret A., additional, Waite, Roger L., additional, Bailey, John A., additional, Kerner, Mallory, additional, Yeldandi, Swetha, additional, Majmundar, Neil, additional, Giordano, John, additional, Morse, Siohban, additional, Miller, David, additional, Fornari, Frank, additional, and Braverman, Eric R., additional

Published
2011
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226. Neuro-psychopharmacogenetics and Neurological Antecedents of Posttraumatic Stress Disorder: Unlocking the Mysteries of Resilience and Vulnerability

Author

Bowirrat, Abdalla, primary, J.H. Chen, Thomas, additional, Blum, Kenneth, additional, Madigan, Margaret, additional, A. Bailey, John, additional, Lih Chuan Chen, Amanda, additional, William Downs, B., additional, R. Braverman, Eric, additional, Radi, Shahien, additional, L. Waite, Roger, additional, Kerner, Mallory, additional, Giordano, John, additional, Morse, Siohban, additional, Oscar-Berman, Marlene, additional, and Gold, Mark, additional

Published
2010
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228. Overcoming qEEG Abnormalities and Reward Gene Deficits during Protracted Abstinence in Male Psychostimulant and Polydrug Abusers Utilizing Putative Dopamine D2Agonist Therapy: Part 2

Author

Blum, Kenneth, primary, Chen, Thomas J. H., additional, Morse, Siobhan, additional, Giordano, John, additional, Chen, Amanda Lih Chaun, additional, Thompson, James, additional, Allen, Cameron, additional, Smolen, Andrew, additional, Lubar, Joel, additional, Stice, Eric, additional, Downs, B. William, additional, Waite, Roger L., additional, Madigan, Margaret A., additional, Kerner, Mallory, additional, Fornari, Frank, additional, and Braverman, Eric R., additional

Published
2010
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229. Do dopaminergic gene polymorphisms affect mesolimbic reward activation of music listening response? Therapeutic impact on Reward Deficiency Syndrome (RDS)

Author

Blum, Kenneth, primary, Chen, Thomas J.H., additional, Chen, Amanda L.H., additional, Madigan, Margaret, additional, Downs, B. William, additional, Waite, Roger L., additional, Braverman, Eric R., additional, Kerner, Mallory, additional, Bowirrat, Abdalla, additional, Giordano, John, additional, Henshaw, Harry, additional, and Gold, Mark S., additional

Published
2010
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230. Healing enhancement of chronic venous stasis ulcers utilizing H-WAVE®device therapy: a case series

Author

Blum, Kenneth, primary, Chen, Amanda LH, additional, Chen, Thomas JH, additional, Downs, B William, additional, Braverman, Eric R, additional, Kerner, Mallory, additional, Savarimuthu, Stella, additional, Bajaj, Anish, additional, Madigan, Margaret, additional, Blum, Seth H, additional, Reinl, Gary, additional, Giordano, John, additional, and DiNubile, Nicholas, additional

Published
2010
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231. Repetitive H-Wave® device stimulation and program induces significant increases in the range of motion of post operative rotator cuff reconstruction in a double-blinded randomized placebo controlled human study

Author

Blum, Kenneth, primary, Chen, Amanda LC, additional, Chen, Thomas JH, additional, Waite, Roger L, additional, Downs, B William, additional, Braverman, Eric R, additional, Kerner, Mallory M, additional, Savarimuthu, Stella M, additional, and DiNubile, Nicholas, additional

Published
2009
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235. Activation instead of blocking mesolimbic dopaminergic reward circuitry is a preferred modality in the long term treatment of reward deficiency syndrome (RDS): a commentary

Author

Blum, Kenneth, primary, Chen, Amanda LihChuan, additional, Chen, Thomas JH, additional, Braverman, Eric R, additional, Reinking, Jeffrey, additional, Blum, Seth H, additional, Cassel, Kimberly, additional, Downs, Bernard W, additional, Waite, Roger L, additional, Williams, Lonna, additional, Prihoda, Thomas J, additional, Kerner, Mallory M, additional, Palomo, Tomas, additional, Comings, David E, additional, Tung, Howard, additional, Rhoades, Patrick, additional, and Oscar-Berman, Marlene, additional

Published
2008
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236. Hypothesizing that Marijuana Smokers are at a Significantly Lower Risk of Carcinogenicity Relative to Tobacco-Non-Marijuana Smokers: Evidenced Based on Statistical Reevaluation of Current Literature

Author

Chen, Amanda L.C., primary, Chen, Thomas J.H., additional, Braverman, Eric R., additional, Acuri, Vanessa, additional, Kerner, Mallory, additional, Varshavskiy, Michael, additional, Braverman, Dasha, additional, Downs, William B., additional, Blum, Seth H., additional, Cassel, Kimberly, additional, and Blum, Kenneth, additional

Published
2008
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238. Mycobiota and Mycotoxins in Traditional Medicinal Seeds from China.

Author

Juan Chen, Amanda, Xiaolin Jiao, Yongjian Hu, Xiaohong Lu, and Weiwei Gao

Subjects
*FUNGI, *MYCOTOXINS, *TRADITIONAL medicine, *CHAETOMIUM globosum, *TOXIGENIC fungi
Abstract

The multi-mycotoxin occurrence for internal and superficial fungi contamination were comprehensively assessed in medicinal seeds used as food or beverage. Based on a polyphasic approach using morphological characters, β-tubulin and ITS gene blast, a total of 27 species belonging to 12 genera were identified from surface-sterilized seeds. Chaetomium globosporum was most predominant (23%), followed by Microascus trigonosporus (12%) and Alternaria alternata (9%). With respect to superficial mycobiota, thirty-four species belonging to 17 genera were detected. Aspergillus niger and Penicillium polonicum were predominant (12% and 15%, respectively). Medicinal seed samples and potential toxigenic fungi were tested for ochratoxin A (OTA) and aflatoxins (AFB1, AFB2, AFG1, AFG2) using UPLC-MS/MS. Platycladi seeds were contaminated with AFB1 (52.0 μg/kg) and tangerine seed was contaminated with OTA (92.3 μg/kg). Subsequent analysis indicated that one A. flavus strain isolated from platycladi seed was able to synthesize AFB1 (102.0 μg/kg) and AFB2 (15.3 μg/kg). Two P. polonicum strains isolated from tangerine and lychee seeds were able to synthesize OTA (4.1 μg/kg and 14.8 μg/kg, respectively). These results identify potential sources of OTA and aflatoxins in medicinal seeds and allude to the need to establish permitted limits for these mycotoxins in these seeds that are commonly consumed by humans. [ABSTRACT FROM AUTHOR]

Published
2015
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239. Effects of Fusarium solani and F. oxysporum Infection on the Metabolism of Ginsenosides in American Ginseng Roots.

Author

Xiaolin Jiao, Xiaohong Lu, Chen, Amanda Juan, Yi Luo, Hao, Jianjun J., and Weiwei Gao

Subjects
FUSARIUM solani, AMERICAN ginseng, FUSARIUM oxysporum, GINSENOSIDES, HERBAL medicine
Abstract

American ginseng (Panax quinquefolius L.) is a highly valuable herb widely used for medicinal treatments. Its pharmacologically important compounds are the ginsenosides, which are secondary metabolites in American ginseng root. The concentrations of ginsenoside in roots can be changed by fungal infection, but it is unclear what specific root tissues are impacted and whether the change is systemic. In this study, American ginseng roots were inoculated with two fungal pathogens (Fusarium solani or F. oxysporum) and the levels of six ginsenosides (Rb1, Rb2, Rc, Rd, Re, and Rg1) were then measured in the phloem and xylem around the discolored lesions and adjacent healthy areas of the root. Results indicated that the growth of Fusarium spp. was strictly limited to phloem, and correspondingly the ginsenoside concentration was only altered in this infected phloem. The concentration of Rg1, Rd, and Rc significantly changed in phloem tissues where F. solani was inoculated, while only Rg1 and Rd changed significantly after F. oxysporum inoculation. However, no changes of any ginsenoside occurred in either xylem or phloem tissue adjacent to the inoculation point. In addition, when two Fusarium spp. were grown on ginsenoside-amended Czapek medium, the majority of ginsenosides were depleted. Therefore, pathogenic Fusarium spp. may reduce ginsenoside levels by consuming them. [ABSTRACT FROM AUTHOR]

Published
2015
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240. Disruption of cell-cell contact-mediated notch signaling via hydrogel encapsulation reduces mesenchymal stem cell chondrogenic potential.

Author

Chen, Amanda X., Hoffman, Michael D., Chen, Caressa S., Shubin, Andrew D., Reynolds, Daniel S., and Benoit, Danielle S. W.

Abstract

Cell-cell contact-mediated Notch signaling is essential for mesenchymal stem cell (MSC) chondrogenesis during development. However, subsequent deactivation of Notch signaling is also required to allow for stem cell chondrogenic progression. Recent literature has shown that Notch signaling can also influence Wnt/β-catenin signaling, critical for MSC differentiation, through perturbations in cell-cell contacts. Traditionally, abundant cell-cell contacts, consistent with development, are emulated in vitro using pellet cultures for chondrogenesis. However, cells are often encapsulated within biomaterials-based scaffolds, such as hydrogels, to improve therapeutic cell localization in vivo. To explore the role of Notch and Wnt/β-catenin signaling in the context of hydrogel-encapsulated MSC chondrogenesis, we compared signaling and differentiation capacity of MSCs in both hydrogels and traditional pellet cultures. We demonstrate that encapsulation within poly(ethylene glycol) hydrogels reduces cell-cell contacts, and both Notch (7.5-fold) and Wnt/β-catenin (84.7-fold) pathway activation. Finally, we demonstrate that following establishment of cell-cell contacts and transient Notch signaling in pellet cultures, followed by Notch signaling deactivation, resulted in a 1.5-fold increase in MSC chondrogenesis. Taken together, these findings support that cellular condensation, and establishment of initial cell-cell contacts is critical for MSC chondrogenesis, and this process is inhibited by hydrogel encapsulation. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 1291-1302, 2015. [ABSTRACT FROM AUTHOR]

Published
2015
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241. The Promise of Higher Pay Woos MBAs, Yet Earnings Haven't Kept Up With Inflation.

Author

McIntyre, Alexander and Chen, Amanda

Subjects
PRICE inflation
Abstract

That's not surprising, given that the median gain in salary from students' pre-MBA jobs to their first jobs out of business school in 2022 was $85,000. The data below sheds light on 2022 MBA grads. (Bloomberg Businessweek) -- The reasons prospective MBA students consider attending business school are multifaceted, but one theme consistently stands above the rest: higher salaries. [Extracted from the article]

Published
2023

242. Unravelling Ultrafast Li Ion Transport in Functionalized Metal–Organic Framework-Based Battery Electrolytes

Author

Cai, Guorui, Chen, Amanda A., Lin, Sharon, Lee, Dong Ju, Yu, Kunpeng, Holoubek, John, Yin, Yijie, Mu, Anthony U., Meng, Ying Shirley, Liu, Ping, Cohen, Seth M., Pascal, Tod A., and Chen, Zheng

Abstract

Nonaqueous fluidic transport and ion solvation properties under nanoscale confinement are poorly understood, especially in ion conduction for energy storage and conversion systems. Herein, metal–organic frameworks (MOFs) and aprotic electrolytes are studied as a robust platform for molecular-level insights into electrolyte behaviors in confined spaces. By employing computer simulations, along with spectroscopic and electrochemical measurements, we demonstrate several phenomena that deviate from the bulk, including modulated solvent molecular configurations, aggregated solvation structures, and tunable transport mechanisms from quasi-solid to quasi-liquid in functionalized MOFs. Technologically, taking advantage of confinement effects may prove useful for addressing stability concerns associated with volatile organic electrolytes while simultaneously endowing ultrafast transport of solvates, resulting in improved battery performance, even at extreme temperatures. The molecular-level insights presented here further our understanding of structure–property relationships of complex fluids at the nanoscale, information that can be exploited for the predictive design of more efficient electrochemical systems.

Published
2023
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244. Acetylcholinesterase inhibition effects of marine fungi.

Author

Liu, Yu-Wei, Shi, Da-Hua, Chen, Amanda-Juan, Zhu, Qiang, Xu, Jia-Tao, and Zhang, Xin-Xin

Subjects
MARINE fungi, ACETYLCHOLINESTERASE inhibitors, ALZHEIMER'S disease treatment, ETHYL acetate, PLANT extracts, CENTRIFUGATION, MARINE sediments
Abstract

Context: To this day, there are no reports that marine compounds isolated from microorganisms of the Lianyungang area of China have been used for the treatment of Alzheimer's disease. Objective: The present study was to isolate fungi from the sea sediment of the Lianyungang area and screen for acetylcholineseterase inhibition activities of ethyl acetate extracts. Materials and methods: Fungi were isolated from the sea sediment and fermented. After centrifugation, the supernate was extracted with ethyl acetate. The ethyl acetate extract was then fractionated into five fractions. Acetylcholinesterase inhibition activities of the ethyl acetate extracts and five sub-fractions were tested at a concentration of 500 μg/mL with the Ellman's method. Results: Forty-three marine fungi were isolated; 15 extracts inhibited acetylcholinestrease >50% and 3 extracts inhibited the acetylcholinesterase >80% at the concentration of 500 μg/mL. The 3 extracts (L1705, S1101, SH0701) inhibited AChE dose-dependently with IC50 values of 11.3 ± 1.2, 72.1 ± 2.3, and 7.8 ± 2.8 μg/mL, respectively. After the extract of SH0701 was fractionated into five fractions, the ethyl acetate fraction possessed the highest acetylcholinesterase inhibitory activity with an inhibition rate of 71.55% at the concentration of 10 μg/mL. The fungus SH0701 was identified as Aspergillus ochraceus SH0701 according to morphology and molecular identification. Discussion and conclusion: The present results indicates that some ethyl acetate extracts of marine fungi isolated from Lianyungang area of China could inhibit AChE potently. Therefore, some novel AChE inhibitors might exist in those extracts. [ABSTRACT FROM AUTHOR]

Published
2014
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246. PROPHET: The Order of the Lyricist.

Author

Chen, Amanda

Subjects
LYRICISTS, PERFORMING arts, PROPHETS, ART centers
Abstract

Throughout the performance, Forté-Saunders often acts as Saunders's shadow, her background movement either offering nonverbal affirmations or subversions, alternate interpretations, to whatever is being spoken aloud. In the personal turned allegory, he and Forté-Saunders playfully take turns occupying the roles of various characters Saunders encounters along Girard Ave, all of whom share religious or spiritual proclivities. When they reposition so that Saunders is opposite Forté-Saunders, back-and-forth volleys of individual gestures, not quite in parallel nor exactly complimentary, reveal a tenderness and dynamic synthesis intrinsic to their personal and working relationship. [Extracted from the article]

Published
2022

247. Investigation of citrinin and monacolin K gene clusters variation among pigment producer Monascus species.

Author

Liu, Anan, Juan Chen, Amanda, Liu, Bingyu, Wei, Qian, Bai, Jian, and Hu, Youcai

Subjects
*GENE clusters, *MONASCUS, *CITRININ, *SPECIES, *FILAMENTOUS fungi, *PIGMENTS, *COLORING matter in food
Abstract

[Display omitted] • The genus Monascus can be delimited into three sections. • Each section has a specialized secondary metabolic gene cluster composition. • Sections A and B produce citrinin and monacolin K respectively. • Monascus sanguineus is genetically incapable of producing citrinin and monacolin K. • Monascus secondary metabolism gene clusters have undergone significant gene loss. The filamentous fungi Monascus spp. have been widely used in the production of food colorants. However, the presence of mycotoxin citrinin and the antihypercholestrolemia agent monacolin K in Monascus -fermented products (MFPs) has raised food safety concerns. Here we de novo -sequenced the genomes of 26 Monascus species and proposed an unprecedented classification system, consist of sections A, B and C, according to the biosynthetic gene clusters (BGCs) distribution and phylogeny results. Based on the absence of citrinin gene cluster, section B species were genetically incapable of synthesizing citrinin. A distinguished section A strain named Monascus sanguineus was believed to be a promising food-pigment-producer particularly owing to the simultaneous inactivation of citrinin and monacolin K clusters. Interestingly, gene losses within Monascus secondary metabolism gene clusters were broadly discovered, which may convey a selective advantage in nutrients and energy competition to support the strong pigment-producing ability. Overall, our sectional delimitation system will reshape the industrial strategies for this economically important fungus. [ABSTRACT FROM AUTHOR]

Published
2022
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248. 31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one: National Harbor, MD, USA. 9-13 November 2016

Author

Lundqvist, Andreas, van Hoef, Vincent, Zhang, Xiaonan, Wennerberg, Erik, Lorent, Julie, Witt, Kristina, Sanz, Laia Masvidal, Liang, Shuo, Murray, Shannon, Larsson, Ola, Kiessling, Rolf, Mao, Yumeng, Sidhom, John-William, Bessell, Catherine A., Havel, Jonathan, Schneck, Jonathan, Chan, Timothy A., Sachsenmeier, Eliot, Woods, David, Berglund, Anders, Ramakrishnan, Rupal, Sodre, Andressa, Weber, Jeffrey, Zappasodi, Roberta, Li, Yanyun, Qi, Jingjing, Wong, Philip, Sirard, Cynthia, Postow, Michael, Newman, Walter, Koon, Henry, Velcheti, Vamsidhar, Callahan, Margaret K., Wolchok, Jedd D., Merghoub, Taha, Lum, Lawrence G., Choi, Minsig, Thakur, Archana, Deol, Abhinav, Dyson, Gregory, Shields, Anthony, Haymaker, Cara, Uemura, Marc, Murthy, Ravi, James, Marihella, Wang, Daqing, Brevard, Julie, Monaghan, Catherine, Swann, Suzanne, Geib, James, Cornfeld, Mark, Chunduru, Srinivas, Agrawal, Sudhir, Yee, Cassian, Wargo, Jennifer, Patel, Sapna P., Amaria, Rodabe, Tawbi, Hussein, Glitza, Isabella, Woodman, Scott, Hwu, Wen-Jen, Davies, Michael A., Hwu, Patrick, Overwijk, Willem W., Bernatchez, Chantale, Diab, Adi, Massarelli, Erminia, Segal, Neil H., Ribrag, Vincent, Melero, Ignacio, Gangadhar, Tara C., Urba, Walter, Schadendorf, Dirk, Ferris, Robert L., Houot, Roch, Morschhauser, Franck, Logan, Theodore, Luke, Jason J., Sharfman, William, Barlesi, Fabrice, Ott, Patrick A., Mansi, Laura, Kummar, Shivaani, Salles, Gilles, Carpio, Cecilia, Meier, Roland, Krishnan, Suba, McDonald, Dan, Maurer, Matthew, Gu, Xuemin, Neely, Jaclyn, Suryawanshi, Satyendra, Levy, Ronald, Khushalani, Nikhil, Wu, Jennifer, Zhang, Jinyu, Basher, Fahmin, Rubinstein, Mark, Bucsek, Mark, Qiao, Guanxi, MacDonald, Cameron, Hylander, Bonnie, Repasky, Elizabeth, Chatterjee, Shilpak, Daenthanasanmak, Anusara, Chakraborty, Paramita, Toth, Kyle, Meek, Megan, Garrett-Mayer, Elizabeth, Nishimura, Michael, Paulos, Chrystal, Beeson, Craig, Yu, Xuezhong, Mehrotra, Shikhar, Zhao, Fei, Evans, Kathy, Xiao, Christine, Holtzhausen, Alisha, Hanks, Brent A., Scharping, Nicole, Menk, Ashley V., Moreci, Rebecca, Whetstone, Ryan, Dadey, Rebekah, Watkins, Simon, Ferris, Robert, Delgoffe, Greg M., Peled, Jonathan, Devlin, Sean, Staffas, Anna, Lumish, Melissa, Rodriguez, Kori Porosnicu, Ahr, Katya, Perales, Miguel, Giralt, Sergio, Taur, Ying, Pamer, Eric, van den Brink, Marcel R. M., Jenq, Robert, Annels, Nicola, Pandha, Hardev, Simpson, Guy, Mostafid, Hugh, Harrington, Kevin, Melcher, Alan, Grose, Mark, Davies, Bronwyn, Au, Gough, Karpathy, Roberta, Shafren, Darren, Ricca, Jacob, Zamarin, Dmitriy, Batista, Luciana, Marliot, Florence, Vasaturo, Angela, Carpentier, Sabrina, Poggionovo, Cécile, Frayssinet, Véronique, Fieschi, Jacques, Van den Eynde, Marc, Pagès, Franck, Galon, Jérôme, Hermitte, Fabienne, Smith, Sean G., Nguyen, Khue, Ravindranathan, Sruthi, Koppolu, Bhanu, Zaharoff, David, Schvartsman, Gustavo, Bassett, Roland, McQuade, Jennifer L., Haydu, Lauren E., Kline, Douglas, Chen, Xiufen, Fosco, Dominick, Kline, Justin, Overacre, Abigail, Chikina, Maria, Brunazzi, Erin, Shayan, Gulidanna, Horne, William, Kolls, Jay, Bruno, Tullia C., Workman, Creg, Vignali, Dario, Adusumilli, Prasad S., Ansa-Addo, Ephraim A, Li, Zihai, Gerry, Andrew, Sanderson, Joseph P., Howe, Karen, Docta, Roslin, Gao, Qian, Bagg, Eleanor A. L., Tribble, Nicholas, Maroto, Miguel, Betts, Gareth, Bath, Natalie, Melchiori, Luca, Lowther, Daniel E., Ramachandran, Indu, Kari, Gabor, Basu, Samik, Binder-Scholl, Gwendolyn, Chagin, Karen, Pandite, Lini, Holdich, Tom, Amado, Rafael, Zhang, Hua, Glod, John, Bernstein, Donna, Jakobsen, Bent, Mackall, Crystal, Wong, Ryan, Silk, Jonathan D., Adams, Katherine, Hamilton, Garth, Bennett, Alan D., Brett, Sara, Jing, Junping, Quattrini, Adriano, Saini, Manoj, Wiedermann, Guy, Brewer, Joanna, Duong, MyLinh, Lu, An, Chang, Peter, Mahendravada, Aruna, Shinners, Nicholas, Slawin, Kevin, Spencer, David M., Foster, Aaron E., Bayle, J. Henri, Bergamaschi, Cristina, Ng, Sinnie Sin Man, Nagy, Bethany, Jensen, Shawn, Hu, Xintao, Alicea, Candido, Fox, Bernard, Felber, Barbara, Pavlakis, George, Chacon, Jessica, Yamamoto, Tori, Garrabrant, Thomas, Cortina, Luis, Powell, Daniel J., Donia, Marco, Kjeldsen, Julie Westerlin, Andersen, Rikke, Westergaard, Marie Christine Wulff, Bianchi, Valentina, Legut, Mateusz, Attaf, Meriem, Dolton, Garry, Szomolay, Barbara, Ott, Sascha, Lyngaa, Rikke, Hadrup, Sine Reker, Sewell, Andrew Kelvin, Svane, Inge Marie, Fan, Aaron, Kumai, Takumi, Celis, Esteban, Frank, Ian, Stramer, Amanda, Blaskovich, Michelle A., Wardell, Seth, Fardis, Maria, Bender, James, Lotze, Michael T., Goff, Stephanie L., Zacharakis, Nikolaos, Assadipour, Yasmine, Prickett, Todd D., Gartner, Jared J., Somerville, Robert, Black, Mary, Xu, Hui, Chinnasamy, Harshini, Kriley, Isaac, Lu, Lily, Wunderlich, John, Robbins, Paul F., Rosenberg, Steven, Feldman, Steven A., Trebska-McGowan, Kasia, Malekzadeh, Parisa, Payabyab, Eden, Sherry, Richard, Gokuldass, Aishwarya, Kopits, Charlene, Rabinovich, Brian, Green, Daniel S., Kamenyeva, Olena, Zoon, Kathryn C., Annunziata, Christina M., Hammill, Joanne, Helsen, Christopher, Aarts, Craig, Bramson, Jonathan, Harada, Yui, Yonemitsu, Yoshikazu, Mwawasi, Kenneth, Denisova, Galina, Giri, Rajanish, Jin, Benjamin, Campbell, Tracy, Draper, Lindsey M., Stevanovic, Sanja, Yu, Zhiya, Weissbrich, Bianca, Restifo, Nicholas P., Trimble, Cornelia L., Hinrichs, Christian S., Tsang, Kwong, Fantini, Massimo, Hodge, James W., Fujii, Rika, Fernando, Ingrid, Jochems, Caroline, Heery, Christopher, Gulley, James, Soon-Shiong, Patrick, Schlom, Jeffrey, Jing, Weiqing, Gershan, Jill, Blitzer, Grace, Weber, James, McOlash, Laura, Johnson, Bryon D., Kiany, Simin, Gangxiong, Huang, Kleinerman, Eugenie S., Klichinsky, Michael, Ruella, Marco, Shestova, Olga, Kenderian, Saad, Kim, Miriam, Scholler, John, June, Carl H., Gill, Saar, Moogk, Duane, Zhong, Shi, Liadi, Ivan, Rittase, William, Fang, Victoria, Dougherty, Janna, Perez-Garcia, Arianne, Osman, Iman, Zhu, Cheng, Varadarajan, Navin, Frey, Alan, Krogsgaard, Michelle, Landi, Daniel, Fousek, Kristen, Mukherjee, Malini, Shree, Ankita, Joseph, Sujith, Bielamowicz, Kevin, Byrd, Tiara, Ahmed, Nabil, Hegde, Meenakshi, Lee, Sylvia, Byrd, David, Thompson, John, Bhatia, Shailender, Tykodi, Scott, Delismon, Judy, Chu, Liz, Abdul-Alim, Siddiq, Ohanian, Arpy, DeVito, Anna Marie, Riddell, Stanley, Margolin, Kim, Magalhaes, Isabelle, Mattsson, Jonas, Uhlin, Michael, Nemoto, Satoshi, Villarroel, Patricio Pérez, Nakagawa, Ryosuke, Mule, James J., Mailloux, Adam W., Mata, Melinda, Nguyen, Phuong, Gerken, Claudia, DeRenzo, Christopher, Gottschalk, Stephen, Mathieu, Mélissa, Pelletier, Sandy, Stagg, John, Turcotte, Simon, Minutolo, Nicholas, Sharma, Prannda, Tsourkas, Andrew, Mockel-Tenbrinck, Nadine, Mauer, Daniela, Drechsel, Katharina, Barth, Carola, Freese, Katharina, Kolrep, Ulrike, Schult, Silke, Assenmacher, Mario, Kaiser, Andrew, Mullinax, John, Hall, MacLean, Le, Julie, Kodumudi, Krithika, Royster, Erica, Richards, Allison, Gonzalez, Ricardo, Sarnaik, Amod, Pilon-Thomas, Shari, Nielsen, Morten, Krarup-Hansen, Anders, Hovgaard, Dorrit, Petersen, Michael Mørk, Loya, Anand Chainsukh, Junker, Niels, Rivas, Charlotte, Parihar, Robin, Rooney, Cliona M., Qin, Haiying, Nguyen, Sang, Su, Paul, Burk, Chad, Duncan, Brynn, Kim, Bong-Hyun, Kohler, M. Eric, Fry, Terry, Rao, Arjun A., Teyssier, Noam, Pfeil, Jacob, Sgourakis, Nikolaos, Salama, Sofie, Haussler, David, Richman, Sarah A., Nunez-Cruz, Selene, Gershenson, Zack, Mourelatos, Zissimos, Barrett, David, Grupp, Stephan, Milone, Michael, Rodriguez-Garcia, Alba, Robinson, Matthew K., Adams, Gregory P., Santos, João, Havunen, Riikka, Siurala, Mikko, Cervera-Carrascón, Víctor, Parviainen, Suvi, Antilla, Marjukka, Hemminki, Akseli, Sethuraman, Jyothi, Santiago, Laurelis, Chen, Jie Qing, Dai, Zhimin, Sha, Huizi, Su, Shu, Ding, Naiqing, Liu, Baorui, Pasetto, Anna, Helman, Sarah R., Rosenberg, Steven A., Burgess, Melissa, Zhang, Hui, Lee, Tien, Klingemann, Hans, Nghiem, Paul, Kirkwood, John M., Rossi, John M., Sherman, Marika, Xue, Allen, Shen, Yueh-wei, Navale, Lynn, Kochenderfer, James N., Bot, Adrian, Veerapathran, Anandaraman, Wiener, Doris, Waller, Edmund K., Li, Jian-Ming, Petersen, Christopher, Blazar, Bruce R., Li, Jingxia, Giver, Cynthia R., Wang, Ziming, Grossenbacher, Steven K., Sturgill, Ian, Canter, Robert J., Murphy, William J., Zhang, Congcong, Burger, Michael C., Jennewein, Lukas, Waldmann, Anja, Mittelbronn, Michel, Tonn, Torsten, Steinbach, Joachim P., Wels, Winfried S., Williams, Jason B., Zha, Yuanyuan, Gajewski, Thomas F., Williams, LaTerrica C., Krenciute, Giedre, Kalra, Mamta, Louis, Chrystal, Xin, Gang, Schauder, David, Jiang, Aimin, Joshi, Nikhil, Cui, Weiguo, Zeng, Xue, Zhao, Zeguo, Hamieh, Mohamad, Eyquem, Justin, Gunset, Gertrude, Bander, Neil, Sadelain, Michel, Askmyr, David, Abolhalaj, Milad, Lundberg, Kristina, Greiff, Lennart, Lindstedt, Malin, Angell, Helen K., Kim, Kyoung-Mee, Kim, Seung-Tae, Kim, Sung, Sharpe, Alan D., Ogden, Julia, Davenport, Anna, Hodgson, Darren R., Barrett, Carl, Lee, Jeeyun, Kilgour, Elaine, Hanson, Jodi, Caspell, Richard, Karulin, Alexey, Lehmann, Paul, Ansari, Tameem, Schiller, Annemarie, Sundararaman, Srividya, Roen, Diana, Ayers, Mark, Levitan, Diane, Arreaza, Gladys, Liu, Fang, Mogg, Robin, Bang, Yung-Jue, O’Neil, Bert, Cristescu, Razvan, Friedlander, Philip, Wassman, Karl, Kyi, Chrisann, Oh, William, Bhardwaj, Nina, Bornschlegl, Svetlana, Gustafson, Michael P., Gastineau, Dennis A., Parney, Ian F., Dietz, Allan B., Carvajal-Hausdorf, Daniel, Mani, Nikita, Schalper, Kurt, Rimm, David, Chang, Serena, Kurland, John, Ahlers, Christoph Matthias, Jure-Kunkel, Maria, Cohen, Lewis, Maecker, Holden, Kohrt, Holbrook, Chen, Shuming, Crabill, George, Pritchard, Theresa, McMiller, Tracee, Pardoll, Drew, Pan, Fan, Topalian, Suzanne, Danaher, Patrick, Warren, Sarah, Dennis, Lucas, White, Andrew M., D’Amico, Leonard, Geller, Melissa, Disis, Mary L., Beechem, Joseph, Odunsi, Kunle, Fling, Steven, Derakhshandeh, Roshanak, Webb, Tonya J., Dubois, Sigrid, Conlon, Kevin, Bryant, Bonita, Hsu, Jennifer, Beltran, Nancy, Müller, Jürgen, Waldmann, Thomas, Duhen, Rebekka, Duhen, Thomas, Thompson, Lucas, Montler, Ryan, Weinberg, Andrew, Kates, Max, Early, Brandon, Yusko, Erik, Schreiber, Taylor H., Bivalacqua, Trinity J., Lunceford, Jared, Nebozhyn, Michael, Murphy, Erin, Loboda, Andrey, Kaufman, David R., Albright, Andrew, Cheng, Jonathan, Kang, S. Peter, Shankaran, Veena, Piha-Paul, Sarina A., Yearley, Jennifer, Seiwert, Tanguy, Ribas, Antoni, McClanahan, Terrill K., Sher, Xinwei, Liu, Xiao Qiao, Joe, Andrew, Plimack, Elizabeth, Forrest-Hay, Alex, Guyre, Cheryl A., Narumiya, Kohei, Delcommenne, Marc, Hirsch, Heather A., Deshpande, Amit, Reeves, Jason, Shu, Jenny, Zi, Tong, Michaelson, Jennifer, Law, Debbie, Trehu, Elizabeth, Sathyanaryanan, Sriram, Hodkinson, Brendan P., Hutnick, Natalie A., Schaffer, Michael E., Gormley, Michael, Hulett, Tyler, Ballesteros-Merino, Carmen, Dubay, Christopher, Afentoulis, Michael, Reddy, Ashok, David, Larry, Jayant, Kumar, Agrawal, Swati, Agrawal, Rajendra, Jeyakumar, Ghayathri, Kim, Seongho, Kim, Heejin, Silski, Cynthia, Suisham, Stacey, Heath, Elisabeth, Vaishampayan, Ulka, Vandeven, Natalie, Viller, Natasja Nielsen, O’Connor, Alison, Chen, Hui, Bossen, Bolette, Sievers, Eric, Uger, Robert, Johnson, Lisa, Kao, Hsiang-Fong, Hsiao, Chin-Fu, Lai, Shu-Chuan, Wang, Chun-Wei, Ko, Jenq-Yuh, Lou, Pei-Jen, Lee, Tsai-Jan, Liu, Tsang-Wu, Hong, Ruey-Long, Kearney, Staci J., Black, Joshua C., Landis, Benjamin J., Koegler, Sally, Hirsch, Brooke, Gianani, Roberto, Kim, Jeffrey, He, Ming-Xiao, Zhang, Bingqing, Su, Nan, Luo, Yuling, Ma, Xiao-Jun, Park, Emily, Kim, Dae Won, Copploa, Domenico, Kothari, Nishi, doo Chang, Young, Kim, Richard, Kim, Namyong, Lye, Melvin, Wan, Ee, Knaus, Hanna A., Berglund, Sofia, Hackl, Hubert, Karp, Judith E., Gojo, Ivana, Luznik, Leo, Hong, Henoch S., Koch, Sven D., Scheel, Birgit, Gnad-Vogt, Ulrike, Kallen, Karl-Josef, Wiegand, Volker, Backert, Linus, Kohlbacher, Oliver, Hoerr, Ingmar, Fotin-Mleczek, Mariola, Billingsley, James M., Koguchi, Yoshinobu, Conrad, Valerie, Miller, William, Gonzalez, Iliana, Poplonski, Tomasz, Meeuwsen, Tanisha, Howells-Ferreira, Ana, Rattray, Rogan, Campbell, Mary, Bifulco, Carlo, Bahjat, Keith, Curti, Brendan, Vetsika, E-K, Kallergi, G., Aggouraki, Despoina, Lyristi, Z., Katsarlinos, P., Koinis, Filippos, Georgoulias, V., Kotsakis, Athanasios, Martin, Nathan T., Aeffner, Famke, Cerkovnik, Logan, Pratte, Luke, Kim, Rebecca, Krueger, Joseph, Martínez-Usatorre, Amaia, Jandus, Camilla, Donda, Alena, Carretero-Iglesia, Laura, Speiser, Daniel E., Zehn, Dietmar, Rufer, Nathalie, Romero, Pedro, Panda, Anshuman, Mehnert, Janice, Hirshfield, Kim M., Riedlinger, Greg, Damare, Sherri, Saunders, Tracie, Sokol, Levi, Stein, Mark, Poplin, Elizabeth, Rodriguez-Rodriguez, Lorna, Silk, Ann, Chan, Nancy, Frankel, Melissa, Kane, Michael, Malhotra, Jyoti, Aisner, Joseph, Kaufman, Howard L., Ali, Siraj, Ross, Jeffrey, White, Eileen, Bhanot, Gyan, Ganesan, Shridar, Monette, Anne, Bergeron, Derek, Amor, Amira Ben, Meunier, Liliane, Caron, Christine, Morou, Antigoni, Kaufmann, Daniel, Liberman, Moishe, Jurisica, Igor, Mes-Masson, Anne-Marie, Hamzaoui, Kamel, Lapointe, Rejean, Mongan, Ann, Ku, Yuan-Chieh, Tom, Warren, Sun, Yongming, Pankov, Alex, Looney, Tim, Au-Young, Janice, Hyland, Fiona, Conroy, Jeff, Morrison, Carl, Glenn, Sean, Burgher, Blake, Ji, He, Gardner, Mark, Omilian, Angela R., Bshara, Wiam, Angela, Omilian, Obeid, Joseph M., Erdag, Gulsun, Smolkin, Mark E., Deacon, Donna H., Patterson, James W., Chen, Lieping, Bullock, Timothy N., Slingluff, Craig L., Loffredo, John T., Vuyyuru, Raja, Beyer, Sophie, Spires, Vanessa M., Fox, Maxine, Ehrmann, Jon M., Taylor, Katrina A., Korman, Alan J., Graziano, Robert F., Page, David, Sanchez, Katherine, Martel, Maritza, De Macedo, Mariana Petaccia, Qin, Yong, Reuben, Alex, Spencer, Christine, Guindani, Michele, Racolta, Adriana, Kelly, Brian, Jones, Tobin, Polaske, Nathan, Theiss, Noah, Robida, Mark, Meridew, Jeffrey, Habensus, Iva, Zhang, Liping, Pestic-Dragovich, Lidija, Tang, Lei, Sullivan, Ryan J., Olencki, Thomas, Hutson, Thomas, Roder, Joanna, Blackmon, Shauna, Roder, Heinrich, Stewart, John, Amin, Asim, Ernstoff, Marc S., Clark, Joseph I., Atkins, Michael B., Sosman, Jeffrey, McDermott, David F., Kluger, Harriet, Halaban, Ruth, Snzol, Mario, Asmellash, Senait, Steingrimsson, Arni, Wang, Chichung, Roman, Kristin, Clement, Amanda, Downing, Sean, Hoyt, Clifford, Harder, Nathalie, Schmidt, Guenter, Schoenmeyer, Ralf, Brieu, Nicolas, Yigitsoy, Mehmet, Madonna, Gabriele, Botti, Gerardo, Grimaldi, Antonio, Ascierto, Paolo A., Huss, Ralf, Athelogou, Maria, Hessel, Harald, Buchner, Alexander, Stief, Christian, Binnig, Gerd, Kirchner, Thomas, Sellappan, Shankar, Thyparambil, Sheeno, Schwartz, Sarit, Cecchi, Fabiola, Nguyen, Andrew, Vaske, Charles, Hembrough, Todd, Spacek, Jan, Vocka, Michal, Zavadova, Eva, Skalova, Helena, Dundr, Pavel, Petruzelka, Lubos, Francis, Nicole, Tilman, Rau T., Hartmann, Arndt, Netikova, Irena, Stump, Julia, Tufman, Amanda, Berger, Frank, Neuberger, Michael, Hatz, Rudolf, Lindner, Michael, Sanborn, Rachel E., Handy, John, Huber, Rudolf M., Winter, Hauke, Reu, Simone, Sun, Cheng, Xiao, Weihua, Tian, Zhigang, Arora, Kshitij, Desai, Niyati, Kulkarni, Anupriya, Rajurkar, Mihir, Rivera, Miguel, Deshpande, Vikram, Ting, David, Tsai, Katy, Nosrati, Adi, Goldinger, Simone, Hamid, Omid, Algazi, Alain, Tumeh, Paul, Hwang, Jimmy, Liu, Jacqueline, Chen, Lawrence, Dummer, Reinhard, Rosenblum, Michael, Daud, Adil, Tsao, Tsu-Shuen, Ashworth-Sharpe, Julia, Johnson, Donald, Bhaumik, Srabani, Bieniarz, Christopher, Couto, Joseph, Farrell, Michael, Ghaffari, Mahsa, Hubbard, Antony, Kosmeder, Jerome, Lee, Cleo, Marner, Erin, Uribe, Diana, Zhang, Hongjun, Zhang, Jian, Zhang, Wenjun, Zhu, Yifei, Morrison, Larry, Tsujikawa, Takahiro, Borkar, Rohan N., Azimi, Vahid, Kumar, Sushil, Thibault, Guillaume, Mori, Motomi, El Rassi, Edward, Clayburgh, Daniel R., Kulesz-Martin, Molly F., Flint, Paul W., Coussens, Lisa M., Villabona, Lisa, Masucci, Giuseppe V., Geiss, Gary, Birditt, Brian, Mei, Qian, Huang, Alan, Eagan, Maribeth A., Ignacio, Eduardo, Elliott, Nathan, Dunaway, Dwayne, Jung, Jaemyeong, Merritt, Chris, Sprague, Isaac, Webster, Philippa, Liang, Yan, Wenthe, Jessica, Enblad, Gunilla, Karlsson, Hannah, Essand, Magnus, Savoldo, Barbara, Dotti, Gianpietro, Höglund, Martin, Brenner, Malcolm K., Hagberg, Hans, Loskog, Angelica, Bernett, Matthew J., Moore, Gregory L., Hedvat, Michael, Bonzon, Christine, Chu, Seung, Rashid, Rumana, Avery, Kendra N., Muchhal, Umesh, Desjarlais, John, Kraman, Matthew, Kmiecik, Katarzyna, Allen, Natalie, Faroudi, Mustapha, Zimarino, Carlo, Wydro, Mateusz, Doody, Jacqueline, Srinivasa, Sreesha P., Govindappa, Nagaraja, Reddy, Praveen, Dubey, Aparajita, Periyasamy, Sankar, Adekandi, Madhukara, Dey, Chaitali, Joy, Mary, van Loo, Pieter Fokko, Veninga, Henrike, Shamsili, Setareh, Throsby, Mark, Dolstra, Harry, Bakker, Lex, Alva, Ajjai, Gschwendt, Juergen, Loriot, Yohann, Bellmunt, Joaquim, Feng, Dai, Poehlein, Christian, Powles, Thomas, Antonarakis, Emmanuel S., Drake, Charles G., Wu, Haiyan, De Bono, Johann, Bannerji, Rajat, Byrd, John, Gregory, Gareth, Opat, Stephen, Shortt, Jake, Yee, Andrew J., Raje, Noopur, Thompson, Seth, Balakumaran, Arun, Kumar, Shaji, Rini, Brian I., Choueiri, Toni K., Mariani, Mariangela, Albiges, Laurence, Haanen, John B., Larkin, James, Schmidinger, Manuela, Magazzù, Domenico, di Pietro, Alessandra, Motzer, Robert J., Borch, Troels Holz, Kongsted, Per, Pedersen, Magnus, Met, Özcan, Boudadi, Karim, Wang, Hao, Vasselli, James, Baughman, Jan E., Wigginton, Jon, Abdallah, Rehab, Ross, Ashley, Park, Jiwon, Grossenbacher, Steven, Luna, Jesus I., Withers, Sita, Culp, William, Chen, Mingyi, Monjazeb, Arta, Kent, Michael S., Chandran, Smita, Danforth, David, Yang, James, Klebanoff, Christopher, Goff, Stephanie, Paria, Biman, Sabesan, Arvind, Srivastava, Abhishek, Kammula, Udai, Richards, Jon, Faries, Mark, Andtbacka, Robert H. I., Diaz, Luis A., Le, Dung T., Yoshino, Takayuki, André, Thierry, Bendell, Johanna, Koshiji, Minori, Zhang, Yayan, Kang, S Peter, Lam, Bao, Jäger, Dirk, Bauer, Todd M., Wang, Judy S., Lee, Jean K., Manji, Gulam A., Kudchadkar, Ragini, Kauh, John S., Tang, Shande, Laing, Naomi, Falchook, Gerald, Garon, Edward B., Halmos, Balazs, Rina, Hui, Leighl, Natasha, Lee, Sung Sook, Walsh, William, Dragnev, Konstanin, Piperdi, Bilal, Rodriguez, Luis Paz-Ares, Shinwari, Nabeegha, Wei, Ziewn, Maas, Mary L, Deeds, Michael, Armstrong, Adam, Peterson, Tim, Steinmetz, Sue, Herzog, Thomas, Backes, Floor J., Copeland, Larry, Del Pilar Estevez Diz, Maria, Hare, Thomas W., Huh, Warner, Kim, Byoung-Gie, Moore, Kathleen M., Oaknin, Ana, Small, William, Tewari, Krishnansu S., Monk, Bradley J., Kamat, Ashish M., Nam, Kijoeng, De Santis, Maria, Dreicer, Robert, Hahn, Noah M., Perini, Rodolfo, Siefker-Radtke, Arlene, Sonpavde, Guru, de Wit, Ronald, Witjes, J. Alfred, Keefe, Stephen, Bajorin, Dean, Armand, Philippe, Kuruvilla, John, Moskowitz, Craig, Hamadani, Mehdi, Zinzani, Pier Luigi, Chlosta, Sabine, Bartlett, Nancy, Sabado, Rachel, Saenger, Yvonne, William, Loging, Donovan, Michael Joseph, Sacris, Erlinda, Mandeli, John, Salazar, Andres M., Powderly, John, Brody, Joshua, Nemunaitis, John, Emens, Leisha, Patnaik, Amita, McCaffery, Ian, Miller, Richard, Laport, Ginna, Coveler, Andrew L., Smith, David C., Grilley-Olson, Juneko E., Goel, Sanjay, Gardai, Shyra J., Law, Che-Leung, Means, Gary, Manley, Thomas, Marrone, Kristen A., Rosner, Gary, Anagnostou, Valsamo, Riemer, Joanne, Wakefield, Jessica, Zanhow, Cynthia, Baylin, Stephen, Gitlitz, Barbara, Brahmer, Julie, Signoretti, Sabina, Li, Wenting, Schloss, Charles, Michot, Jean-Marie, Ding, Wei, Christian, Beth, Marinello, Patricia, Shipp, Margaret, Najjar, Yana G., Lin, Butterfield, Lisa H., Tarhini, Ahmad A., Davar, Diwakar, Zarour, Hassane, Rush, Elizabeth, Sander, Cindy, Fu, Siqing, Bauer, Todd, Molineaux, Chris, Bennett, Mark K., Orford, Keith W., Papadopoulos, Kyriakos P., Padda, Sukhmani K., Shah, Sumit A., Colevas, A Dimitrios, Narayanan, Sujata, Fisher, George A., Supan, Dana, Wakelee, Heather A., Aoki, Rhonda, Pegram, Mark D., Villalobos, Victor M., Liu, Jie, Takimoto, Chris H., Chao, Mark, Volkmer, Jens-Peter, Majeti, Ravindra, Weissman, Irving L., Sikic, Branimir I., Yu, Wendy, Conlin, Alison, Ruzich, Janet, Lewis, Stacy, Acheson, Anupama, Kemmer, Kathleen, Perlewitz, Kelly, Moxon, Nicole M., Mellinger, Staci, McArthur, Heather, Juhler-Nøttrup, Trine, Desai, Jayesh, Markman, Ben, Sandhu, Shahneen, Gan, Hui, Friedlander, Michael L., Tran, Ben, Meniawy, Tarek, Lundy, Joanne, Colyer, Duncan, Ameratunga, Malaka, Norris, Christie, Yang, Jason, Li, Kang, Wang, Lai, Luo, Lusong, Qin, Zhen, Mu, Song, Tan, Xuemei, Song, James, Millward, Michael, Katz, Matthew H. G., Bauer, Todd W., Varadhachary, Gauri R., Acquavella, Nicolas, Merchant, Nipun, Petroni, Gina, Rahma, Osama E., Chen, Mei, Song, Yang, Puhlmann, Markus, Khattri, Arun, Brisson, Ryan, Harvey, Christopher, Shah, Jatin, Mateos, Maria Victoria, Matsumoto, Morio, Blacklock, Hilary, Rocafiguera, Albert Oriol, Goldschmidt, Hartmut, Iida, Shinsuke, Yehuda, Dina Ben, Ocio, Enrique, Rodríguez-Otero, Paula, Jagannath, Sundar, Lonial, Sagar, Kher, Uma, San-Miguel, Jesus, de Oliveira, Moacyr Ribeiro, Yimer, Habte, Rifkin, Robert, Schjesvold, Fredrik, Ghori, Razi, Spreafico, Anna, Lee, Victor, Ngan, Roger K. C., To, Ka Fai, Ahn, Myung Ju, Ng, Quan Sing, Lin, Jin-Ching, Swaby, Ramona F., Gause, Christine, Saraf, Sanatan, Chan, Anthony T. 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Published
2016
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250. The Marc Pro Device Improves Muscle Performance and Recovery from Concentric and Eccentric Exercise Induced Muscle Fatigue in Humans: A Pilot Study.

Author

Westcott, Wayne L., Chen, Thomas, Neric, Francis B., DiNubile, Nicholas, Bowirrat, Abdalla, Madigan, Margaret, Downs, B. William, Giordano, John, Morse, Siobhan, Chen, Amanda L.C., Bajaj, Anish, Kerner, Mallory, Braverman, Eric, Reinl, Gary, Blakemore, Max, Whitehead, Scott, Sacks, Lester, and Blum, Kenneth

Subjects
MEDICAL equipment, EXERCISE physiology, FATIGUE (Physiology), DELAYED onset muscle soreness, PILOT projects, PHYSICAL fitness, MUSCLE contraction
Abstract

Westcott WL, Chen T, Neric FB, DiNubile N, Bowirrat A, Madigan M, Downs BW, Giordano J, Morse S, LC Chen A, Bajaj A, Kerner M, Braverman E, Reinl G, Blakemore M, Whitehead S, Sacks L, Blum K. The Marc Pro™ Device Improves Muscle Performance and Recovery from Concentric and Eccentric Exercise Induced Muscle Fatigue in Humans: A Pilot Study. JEPonline 2011;14(2):55-67. To date, a product or routine that consistently relieves delayed onset muscle soreness (DOMS) caused by eccentric exercise has yet to be identified. Our latest research results indicate that a new device called Marc Pro™ (MPD) significantly improves muscle recovery and muscle endurance from combined concentric and eccentric exercise in healthy recreational exercisers. In the first study, 14 subjects (no prior soreness upon study entry) performed strength training activity (leg extension exercise with eccentric emphasis) to produce DOMS in the quadriceps muscles. All participants received one-hour of MPD stimulation on the right leg only following the exercise session whereby each participant served as their own control. One day later, assessment of muscle soreness revealed significantly less discomfort in the right leg (MPD) than in the left leg (no MPD) in all subjects and in responders, respectively ( p < 0.008; p < 0.002 ). The number of repetitions completed with the right leg (MPD) was significantly greater than the number of repetitions completed with the left leg (no MPD) in all subjects and in responders, respectively (p < 0.03; p < 0.008). In the second experiment, 13 subjects (no prior soreness upon study entry) utilized a modestly challenging uphill/downhill hike to produce DOMS in the quadriceps muscles. Following the hike the subjects' right leg received MPD stimulation for 60 minutes, whereas the left leg received no MPD application. Reported soreness was significantly less in the right leg (MPD) than in the left leg (no MPD) in all participants and in responders, respectively (p < 0.0008; p < 0.0002). These results suggest that MPD stimulation results in a significant reduction in DOMS following strenuous unaccustomed eccentric exercise and significantly greater muscle endurance performance, as measured by leg extension repetitions. Investigation of Marc Pro in a larger population is underway and must await confirmation. [ABSTRACT FROM AUTHOR]

Published
2011

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