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Aim: To evaluate whether the application of sorafenib during the peri-operative period of liver transplantation improves prognosis in liver cancer patients., Methods: We searched PubMed, EMBASE and MEDLINE for eligible articles. A total of 4 studies were found that fulfilled the previously agreed-upon standards. We then performed a systematic review and meta-analysis on the enrolled trials that met the inclusion criteria., Results: Out of the 104 studies identified in the database, 82 were not clinical experiments, and 18 did not fit the inclusion standards. Among the remaining 4 articles, only 1 was related to the preoperative use of sorafenib, whereas the other 3 were related to its postoperative use. As the heterogeneity among the 4 studies was high, with an I(2) of 86%, a randomized effect model was applied to pool the data. The application of sorafenib before liver transplantation had a hazard ratio (HR) of 3.29 with a 95% confidence interval (CI) of 0.33-32.56. The use of sorafenib after liver transplantation had an HR of 1.44 (95%CI: 0.27-7.71). The overall pooled HR was 1.68 (95%CI: 0.41-6.91)., Conclusion: The results showed that the use of sorafenib during the peri-operative period of liver transplantation did not improve patient survival significantly. In fact, sorafenib could even lead to a worse prognosis, as its use may increase the hazard of poor survival.

In order to study the influencing factors on Raman spectroscopy, we research a series of comparative Raman spectroscopy of multi-walled carbon nanotubes (MWCNT) with different tube diameter and length. The results suggest that the G peak and D peak of MWCNT are all red-shifted as compared to that of polycrystalline graphite; In the same conditions, the peak intensity (G peak and D peak) is directly proportional to the diameter of the MWCNT, and inversely proportional to the length of the MWCNT; G peak frequency shift is closely related to the MWCNT diameter and length, which are inversely proportional to the diameter (with identical results of the single-walled carbon nanotube radial breathing modes) and direct proportional to the length. While, the influences of the diameter and length on D peak frequency shift are weak, and future analysis for the reason of this kind of phenomenon is as follows. Subsequently, we investigated the relation between D peak frequency shift and MWCNT aspect ratio, the relationship between G peak frequency shift and aspect ratio is nearly linear increase. Using the same analysis method, we plotted the different graphs of G peak and D peak intensity vs the aspect ratio of MWCNT, respectively. As the expected, the linear degression relation are existent in the two relationships.

We report on a case of a 65-year-old Chinese male with locally advanced gastric adenocarcinoma achieving pathological complete response after neoadjuvant chemotherapy with capecitabine and oxaliplatin (XELOX) regimen. He underwent esophagogastroduodenoscopy, which revealed a 6x5cm gastric ulcer. Biopsy of gastric ulcer revealed adenocarcinoma. Further workups with abdominal enhancement computed tomography (CT) staged his cancer as T4N2M0. He received 2 cycles of neoadjuvant chemotherapy with XELOX without severe toxicity. Afterwards, he underwent curative surgery consisting of total gastrectomy with extended D2 lymph node dissections and a Roux-en-Y esophagojejunostomy. On microscopic examination, no tumor cells were detected in the ulcer scar of the resected stomach and in the regional lymph nodes. The benefit of XELOX regimen as neoadjuvant chemotherapy in gastric cancer is worth further investigation.

Raman spectrum was applied to analyze the synthesis mechanism of nanostructure porous ZnO microspheres prepared via hydrothermal method assisted with trisodium citrate. The Raman spectrum characteristics of the sample revealed that the ZnO microspheres contained Zn-citrate complex, which was the complex of citrate acid group and Zn2+ in the reaction solution. The complex was chemisorbed on (204) and (503) faces of the Zn(OH)2 crystallite in the reacting solution, resulting in Zn(OH)2 nanosheet from the crystallite. Large quantities of Zn(OH)2 nanosheets aggregated as porous microspheres in hydrothermal process. Zn-citrate complex chemisorbed on the nanosheet improved the thermal stability of Zn(OH)2, which means a decomposition temperature over 200 degrees C. Nanostructure porous ZnO microspheres were obtained by heating Zn(OH)2 microspheres at 300 degrees C and the nanosheet structure was maintained.

Remote sensing spectrometers were widely used in the fields such as spectral measure and trace gas supervision in atmosphere. The instrument response functions should be measured to eliminate the effect of the spectrometer. The instrument response functions of MCT detector and InSb detector in BLUKER TENSOR 37 passive FTIR spectrometer were measured in the present paper. The instrument response functions and background functions were offered with different temperature interval. The instrument response functions of MCT detector increased with temperature, but it was the reverse for InSb detector. The background functions of InSb detector increased with temperature, and the reverse for MCT detector.