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201. Efficacy of etravirine combined with darunavir or other ritonavir-boosted protease inhibitors in HIV-1-infected patients:an observational study using pooled European cohort data

Author: Vingerhoets, J, Calvez, V, Flandre, P, Marcelin, A-G, Ceccherini-Silberstein, F, Perno, C-F, Mercedes Santoro, M, Bateson, R, Nelson, M, Cozzi-Lepri, A, Grarup, J, Lundgren, J, Incardona, F, Kaiser, R, Sonnerborg, A, Clotet, B, Paredes, R, Günthard, H F, Ledergerber, B, Hoogstoel, A, Nijs, S, Tambuyzer, L, Lavreys, L, Opsomer, M, Vingerhoets, J, Calvez, V, Flandre, P, Marcelin, A-G, Ceccherini-Silberstein, F, Perno, C-F, Mercedes Santoro, M, Bateson, R, Nelson, M, Cozzi-Lepri, A, Grarup, J, Lundgren, J, Incardona, F, Kaiser, R, Sonnerborg, A, Clotet, B, Paredes, R, Günthard, H F, Ledergerber, B, Hoogstoel, A, Nijs, S, Tambuyzer, L, Lavreys, L, and Opsomer, M
Abstract: OBJECTIVES: This observational study in antiretroviral treatment-experienced, HIV-1-infected adults explored the efficacy of etravirine plus darunavir/ritonavir (DRV group; n = 999) vs. etravirine plus an alternative boosted protease inhibitor (other PI group; n = 116) using pooled European cohort data.METHODS: Two international (EuroSIDA; EUResist Network) and five national (France, Italy, Spain, Switzerland and UK) cohorts provided data (collected in 2007-2012). Stratum-adjusted (for confounding factors) Mantel-Haenszel differences in virological responses (viral load < 50 HIV-1 RNA copies/mL) and odds ratios (ORs) with 95% confidence intervals (CIs) were derived.RESULTS: Baseline characteristics were balanced between groups except for previous use of antiretrovirals (≥ 10: 63% in the DRV group vs. 49% in the other PI group), including previous use of at least three PIs (64% vs. 53%, respectively) and mean number of PI resistance mutations (2.3 vs. 1.9, respectively). Week 24 responses were 73% vs. 75% (observed) and 49% vs. 43% (missing = failure), respectively. Week 48 responses were 75% vs. 73% and 32% vs. 30%, respectively. All 95% CIs around unadjusted and adjusted differences encompassed 0 (difference in responses) or 1 (ORs). While ORs by cohort indicated heterogeneity in response, for pooled data the difference between unadjusted and adjusted for cohort ORs was small.CONCLUSIONS: These data do not indicate a difference in response between the DRV and other PI groups, although caution should be applied given the small size of the other PI group and the lack of randomization. This suggests that the efficacy and virology results from DUET can be extrapolated to a regimen of etravirine with a boosted PI other than darunavir/ritonavir.
Published: 2015

202. Evaluation of the prognostic value of impaired renal function on clinical progression in a large cohort of HIV-infected people seen for care in Italy

Author: Bandera, A, Gori, A, Sabbatini, F, Madeddu, G, Bonora, S, Libertone, R, Mastroianni, C, Bonfanti, P, Monforte, A, Cozzi Lepri, A, Giacometti, A, Costantini, A, Mazzoccato, S, Angarano, G, Monno, L, Santoro, C, Maggiolo, F, Suardi, C, Viale, P, Borderi, M, Vanino, E, Verucchi, G, Castelli, F, Roldan, E, Minardi, C, Quirino, T, Abeli, C, Manconi, P, Piano, P, Vecchiet, J, Falasca, K, Sighinolfi, L, Segala, D, Mazzotta, F, Lo Caputo, S, Cassola, G, Viscoli, C, Di Biagio, A, Alessandrini, A, Piscopo, R, Mazzarello, G, Belvisi, V, Caramma, I, Chiodera, A, Castelli, P, Moroni, M, Puoti, M, Galli, M, Lazzarin, A, Rizzardini, G, Ridolfo, A, Piolini, R, Rusconi, S, Balotta, C, Castagna, A, Marchetti, G, Tincati, C, Cicconi, P, Moioli, M, Cinque, P, Gianotti, N, Salpietro, S, Galli, L, Carenzi, L, Iardino, R, Tavelli, A, Mussini, C, Guaraldi, G, Marcotullio, S, Puzzolante, C, Lapadula, G, Abrescia, N, Chirianni, A, Borgia, G, Maddaloni, A, Gargiulo, M, Gentile, I, Orlando, R, Baldelli, F, Francisci, D, Parruti, G, Ursini, T, Magnani, G, Ursitti, M, Cauda, R, Antinori, A, Andreoni, M, Vullo, V, Ceccherini Silberstein, F, Cingolani, A, Girardi, E, D'Avino, A, Fanti, I, Gallo, L, Ippolito, G, Perno, C, Lichtner, M, Capobianchi, M, Nicastri, E, Acinapura, R, Ammassari, A, Capozzi, M, Tebano, G, Lorenzini, P, Von Schloesser, F, Zaccarelli, M, Viviani, F, Sasset, L, Mura, M, De Luca, A, Rossetti, B, Caramello, P, Di Perri, G, Orofino, G, Sciandra, M, Bassetti, M, Londero, A, Pellizzer, G, Manfrin, V, Manfrin, V., GORI, ANDREA, Bandera, A, Gori, A, Sabbatini, F, Madeddu, G, Bonora, S, Libertone, R, Mastroianni, C, Bonfanti, P, Monforte, A, Cozzi Lepri, A, Giacometti, A, Costantini, A, Mazzoccato, S, Angarano, G, Monno, L, Santoro, C, Maggiolo, F, Suardi, C, Viale, P, Borderi, M, Vanino, E, Verucchi, G, Castelli, F, Roldan, E, Minardi, C, Quirino, T, Abeli, C, Manconi, P, Piano, P, Vecchiet, J, Falasca, K, Sighinolfi, L, Segala, D, Mazzotta, F, Lo Caputo, S, Cassola, G, Viscoli, C, Di Biagio, A, Alessandrini, A, Piscopo, R, Mazzarello, G, Belvisi, V, Caramma, I, Chiodera, A, Castelli, P, Moroni, M, Puoti, M, Galli, M, Lazzarin, A, Rizzardini, G, Ridolfo, A, Piolini, R, Rusconi, S, Balotta, C, Castagna, A, Marchetti, G, Tincati, C, Cicconi, P, Moioli, M, Cinque, P, Gianotti, N, Salpietro, S, Galli, L, Carenzi, L, Iardino, R, Tavelli, A, Mussini, C, Guaraldi, G, Marcotullio, S, Puzzolante, C, Lapadula, G, Abrescia, N, Chirianni, A, Borgia, G, Maddaloni, A, Gargiulo, M, Gentile, I, Orlando, R, Baldelli, F, Francisci, D, Parruti, G, Ursini, T, Magnani, G, Ursitti, M, Cauda, R, Antinori, A, Andreoni, M, Vullo, V, Ceccherini Silberstein, F, Cingolani, A, Girardi, E, D'Avino, A, Fanti, I, Gallo, L, Ippolito, G, Perno, C, Lichtner, M, Capobianchi, M, Nicastri, E, Acinapura, R, Ammassari, A, Capozzi, M, Tebano, G, Lorenzini, P, Von Schloesser, F, Zaccarelli, M, Viviani, F, Sasset, L, Mura, M, De Luca, A, Rossetti, B, Caramello, P, Di Perri, G, Orofino, G, Sciandra, M, Bassetti, M, Londero, A, Pellizzer, G, Manfrin, V, Manfrin, V., and GORI, ANDREA
Abstract: Whilst renal dysfunction, especially mild impairment (60 die;ve (Icona) Foundation Study collected between January 2000 and February 2014 with at least two creatinine values available. eGFR (CKD-epi) and renal dysfunction defined using a priori cut-offs of 60 (severely impaired) and 90 ml/min/1.73m2 (mildly impaired). Characteristics of patients were described after stratification in these groups and compared using chi-square test (categorical variables) or Kruskal Wallis test comparing median values. Follow-up accrued from baseline up to the date of the CCVD or AIDS related events or death or last available visit. Kaplan Meier curves were used to estimate the cumulative probability of occurrence of the events over time. Adjusted analysis was performed using a proportional hazards Cox regression model. We included 7,385 patients, observed for a median follow-up of 43 months (interquartile range [IQR]: 21-93 months). Over this time, 130 cerebro-cardiovascular events (including 11 deaths due to CCVD) and 311 AIDS-related events (including 45 deaths) were observed. The rate of CCVD events among patients with eGFR >90, 60-89, <60 ml/min, was 2.91 (95% CI 2.30-3.67), 4.63 (95% CI 3.51-6.11) and 11.9 (95% CI 6.19-22.85) per 1,000 PYFU respectively, with an unadjusted hazard ratio (HR) of 4.14 (95%CI 2.07-8.29) for patients with eGFR <60 ml/min and 1.58 (95%CI 1.10-2.27) for eGFR 60-89 compared to those with eGFR ≥90. Of note, these estimates are adjusted for traditional cardiovascular risk factors (e.g. smoking, diabetes, hypertension, dyslipidemia). Incidence of AIDS-related events was 9.51 (95%CI 8.35-10.83), 6.04 (95%CI 4.74-7.71) and 25.0 (95% CI 15.96-39.22) per 1,000 PYFU, among patients with eGFR >90, 60-89, <60 ml/min, respectively, with an unadjusted HR of 2.49 (95%CI 1.56-3.97) for patients with eGFR <60 ml/min and 0.68 (95%CI 0.52-0.90) for eGFR 60-89. The risk of AIDS events was significantly lower in mild renal dysfunction group even after adjustment for HIV
Published: 2015

203. CD4/CD8 ratio normalisation and non-AIDS-related events in individuals with HIV who achieve viral load suppression with antiretroviral therapy: An observational cohort study

Author: Mussini, Cristina, Lorenzini, Patrizia, Cozzi Lepri, Alessandro, Lapadula, Giuseppe, Marchetti, Giulia, Nicastri, Emanuele, Cingolani, Antonella, Lichtner, Miriam, Antinori, Andrea, Gori, Andrea, Monforte, Antonella d'Arminio, Moroni, M., Andreoni, M., Angarano, G., Antinori, A., d'Arminio Monforte, A., Castelli, F., Cauda, Roberto, Di Perri, G., Galli, M., Iardino, R., Ippolito, G., Lazzarin, A., Perno, C. F., von Schloesser, F., Viale, P., Castagna, A., Ceccherini Silberstein, F., Cozzi Lepri, A., Girardi, E., Lo Caputo, S., Mussini, C., Puoti, M., Ammassari, A., Balotta, C., Bonfanti, P., Bonora, S., Borderi, M., Capobianchi, M. R., Cingolani, A., Cinque, P., De Luca, Andrea, Di Biagio, A., Gianotti, N., Gori, A., Guaraldi, G., Lapadula, G., Lichtner, M., Madeddu, Giordano, Maggiolo, F., Marchetti, G., Marcotullio, S., Monno, L., Quiros Roldan, E., Rusconi, S., Saracino, A., Cicconi, P., Fanti Galli, I., Lorenzini, P., Tavelli, A., Giacometti, A., Costantini, A., Mazzoccato, S., Santoro, C., Suardi, C., Vanino, E., Verucchi, G., Minardi, C., Quirino, T., Abeli, C., E. Manconi, P., Piano, P., Vecchiet, J., Falasca, K., Sighinolfi, L., Segala, D., Mazzotta, F., Cassola, G., Viscoli, C., Alessandrini, A., Piscopo, R., Mazzarello, G., Mastroianni, C., Belvisi, V., Caramma, I., Chiodera, A., Castelli, A. P., Rizzardini, G., Ridolfo, A. L., Piolini, R., Salpietro, S., Carenzi, L., Moioli, M. C., Tincati, C., Puzzolante, C., Abrescia, N., Chirianni, A., Guida, M. G., Gargiulo, M., Baldelli, F., Francisci, D., Parruti, G., Ursini, T., Magnani, G., Ursitti, M. A., Cauda, R., Vullo, V., D'Avino, A., Gallo, L., Nicastri, E., Acinapura, R., Capozzi, M., Libertone, R., Tebano, G., Cattelan, A., Sasset, L., Mura, M. S., De Luca, A., Rossetti, B., Caramello, P., Orofino, G. C., Sciandra, M., Bassetti, M., Londero, A., Pellizzer, G., Manfrin, V., Cingolani, Antonella (ORCID:0000-0002-3793-2755), Cauda, Roberto (ORCID:0000-0002-1498-4229), De Luca, Andrea (ORCID:0000-0002-8311-6935), Mussini, Cristina, Lorenzini, Patrizia, Cozzi Lepri, Alessandro, Lapadula, Giuseppe, Marchetti, Giulia, Nicastri, Emanuele, Cingolani, Antonella, Lichtner, Miriam, Antinori, Andrea, Gori, Andrea, Monforte, Antonella d'Arminio, Moroni, M., Andreoni, M., Angarano, G., Antinori, A., d'Arminio Monforte, A., Castelli, F., Cauda, Roberto, Di Perri, G., Galli, M., Iardino, R., Ippolito, G., Lazzarin, A., Perno, C. F., von Schloesser, F., Viale, P., Castagna, A., Ceccherini Silberstein, F., Cozzi Lepri, A., Girardi, E., Lo Caputo, S., Mussini, C., Puoti, M., Ammassari, A., Balotta, C., Bonfanti, P., Bonora, S., Borderi, M., Capobianchi, M. R., Cingolani, A., Cinque, P., De Luca, Andrea, Di Biagio, A., Gianotti, N., Gori, A., Guaraldi, G., Lapadula, G., Lichtner, M., Madeddu, Giordano, Maggiolo, F., Marchetti, G., Marcotullio, S., Monno, L., Quiros Roldan, E., Rusconi, S., Saracino, A., Cicconi, P., Fanti Galli, I., Lorenzini, P., Tavelli, A., Giacometti, A., Costantini, A., Mazzoccato, S., Santoro, C., Suardi, C., Vanino, E., Verucchi, G., Minardi, C., Quirino, T., Abeli, C., E. Manconi, P., Piano, P., Vecchiet, J., Falasca, K., Sighinolfi, L., Segala, D., Mazzotta, F., Cassola, G., Viscoli, C., Alessandrini, A., Piscopo, R., Mazzarello, G., Mastroianni, C., Belvisi, V., Caramma, I., Chiodera, A., Castelli, A. P., Rizzardini, G., Ridolfo, A. L., Piolini, R., Salpietro, S., Carenzi, L., Moioli, M. C., Tincati, C., Puzzolante, C., Abrescia, N., Chirianni, A., Guida, M. G., Gargiulo, M., Baldelli, F., Francisci, D., Parruti, G., Ursini, T., Magnani, G., Ursitti, M. A., Cauda, R., Vullo, V., D'Avino, A., Gallo, L., Nicastri, E., Acinapura, R., Capozzi, M., Libertone, R., Tebano, G., Cattelan, A., Sasset, L., Mura, M. S., De Luca, A., Rossetti, B., Caramello, P., Orofino, G. C., Sciandra, M., Bassetti, M., Londero, A., Pellizzer, G., Manfrin, V., Cingolani, Antonella (ORCID:0000-0002-3793-2755), Cauda, Roberto (ORCID:0000-0002-1498-4229), and De Luca, Andrea (ORCID:0000-0002-8311-6935)
Abstract: Background: In patients with HIV, immune reconstitution after antiretroviral therapy (ART) is often incomplete. We assessed the probability of patients reaching a CD4/CD8 ratio of 1 or more after the start of ART and its association with the onset of non-AIDS-defining events and death. Methods: We did an analysis of the ICONA cohort, which recruited treatment-naive patients with HIV in Italy. We included participants in the cohort who started ART, reached an undetectable viral load (≤80 copies per mL), and had a CD4/CD8 ratio of less than 0·8 at the time of an undetectable viral load. We defined ratio normalisation in patients as two consecutive values of 1 or more. We used Kaplan-Meier curves to estimate the cumulative probability of ratio normalisation. We then used Poisson regression models to identify factors independently associated with normalisation and with progression to non-AIDS-defining events or death. Findings: We included 3236 participants, enrolled between Jan 22, 1997, and Feb 25, 2013. At the start of ART, median CD4/CD8 ratio in our population was 0·39 (IQR 0·26-0·55). 458 (14%) patients reached a CD4/CD8 ratio of 1 or more; the estimated probability of normalisation was 4·4% (95% CI 3·7-5·2) by 1 year from baseline, 11·5% (10·2-13·0) by 2 years, and 29·4% (26·7-32·4) by 5 years. Factors associated with normalisation were high pre-ART CD4 cell counts, a high CD4/CD8 ratio at baseline, and negative cytomegalovirus serological findings. The incidence rate of non-AIDS-defining events for patients with a CD4/CD8 ratio of less than 0·30 (4·2 per 100 patient-years, 95% CI 3·4-5·3) was double that for those with a ratio of 0·30-0·45 (2·3, 2·1-2·5) or more than 0·45 (2·2, 1·7-2·9). A ratio of less than 0·30 was independently associated with an increased risk of non-AIDS-defining events or death compared with one of more than 0·45. Interpretation: Few patients had normalised CD4/CD8 ratios, even though they had viral suppression. Low ratios were associated
Published: 2015

204. Drug-resistance development differs between HIV-1-infected patients failing first-line antiretroviral therapy containing nonnucleoside reverse transcriptase inhibitors with and without thymidine analogues

Author: Santoro, M, Sabin, C, Forbici, F, Bansi, L, Dunn, D, Fearnhill, E, Boumis, E, Nicastri, E, Antinori, A, Palamara, G, Callegaro, A, Francisci, Daniela, Zoncada, A, Maggiolo, F, Zazzi, M, Perno, C, Ceccherini Silberstein, F, and Mussini, C.
Subjects: Adult, Male, genotypic resistance test, Anti-HIV Agents, Drug Resistance, Organophosphonates, Antiretroviral Therapy, HIV Infections, Deoxycytidine, Antiretroviral Therapy, Highly Active, Drug Resistance, Viral, Emtricitabine, Humans, Highly Active, Viral, Treatment Failure, Tenofovir, virological failure, resistance to reverse transcriptase inhibitors, Adenine, Middle Aged, Viral Load, Settore MED/07 - Microbiologia e Microbiologia Clinica, Dideoxynucleosides, HIV Reverse Transcriptase, CD4 Lymphocyte Count, Drug Combinations, first-line regimen, Female, HIV-1, Lamivudine, Thymidine, Zidovudine
Abstract: We evaluated the emergence of drug resistance in patients failing first-line regimens containing one nonnucleoside reverse transcriptase inhibitor (NNRTI) administered with zidovudine (ZDV) + lamivudine (the ZDV group) or non-thymidine analogues (non-TAs) (tenofovir or abacavir, + lamivudine or emtricitabine; the non-TA group).Three hundred HIV-1-infected patients failing a first-line NNRTI-containing regimen (nevirapine, n = 148; efavirenz, n = 152) were included in the analysis. Virological failure was defined as viraemia ≥ 400 HIV-1 RNA copies/mL for the first time at least 6 months after starting the NNRTI-based regimen. For each patient, a genotypic resistance test at failure was available. The presence of drug-resistance mutations in HIV-1 reverse transcriptase was evaluated by comparing patients treated with NNRTI + zidovudine + lamivudine vs. those treated with NNRTI + non-TA.A total of 208 patients were failing with NNRTI + zidovudine + lamivudine and 92 with NNRTI + non-TA. No significant differences were observed between the non-TA group and the ZDV group regarding the time of virological failure [median (interquartile range): 12 (8-25) vs. 13 (9-32) months, respectively; P = 0.119] and viraemia [median (interquartile range): 4.0 (3.2-4.9) vs. 4.0 (3.3-4.7) log₁₀ copies/mL, respectively; P = 0.894]. Resistance to reverse transcriptase inhibitors (RTIs) occurred at a significant lower frequency in the non-TA group than in the ZDV group (54.3 vs. 75.5%, respectively; P = 0.001). This difference was mainly attributable to a significantly lower prevalence of NNRTI resistance (54.3 vs. 74.0%, respectively; P = 0.002) and of the nucleoside reverse transcriptase inhibitor (NRTI) mutation M184V (23.9 vs. 63.5%, respectively; P 0.001) in the non-TA group compared with the ZDV group. As expected, the mutation K65R was found only in the non-TA group (18.5%; P 0.001).At first-line regimen failure, a lower prevalence of RTI resistance was found in patients treated with NNRTI + non-TA compared with those treated with NNRTI + zidovudine + lamivudine. These results confirm that the choice of backbone may influence the prevalence of drug resistance at virological failure.
Published: 2013

205. Key genetic signatures in the whole pre-S1/Pre-S2/s gene correlate eith HBV-induced carcinogenesis by affecting HBsAG secretion and release

Author: Andreoni, M., Sarrecchia, C., Cento, V., Bertoli, A., Angelico, M., Vecchiet, J., Mari, T., Iapadre, N., Salpini, R., Verheyen, Jens, Aragri, M., Alteri, C., Pasquazzi, C., Svicher, V., Gori, C., Gubertini, G., Fleury, H., Perno, C.-F., Neumann-Fraune, M., Barlattani, A., Trimoulet, P., Di Maio, V.-C., Mirabelli, C., Ceccherini-Silberstein, F., and Micheli, V.
Subjects: Medizin
Published: 2013

206. TB Meningitis in HIV-Positive Patients in Europe and Argentina: Clinical Outcome and Factors Associated with Mortality

Author: Efsen, A. M. W., Panteleev, A. M., Grint, D., Podlekareva, D. N., Vassilenko, A., Rakhmanova, A., Zeltina, I., Losso, M. H., Miller, R. F., Girardi, E., Cayla, J., Post, F. A., Miro, J. M., Bruyand, M., Furrer, H., Obel, N., Lundgren, J. D., Mocroft, A., Kirk, O., Toibaro, J. J., Warley, E., Tamayo, N., Cristina Ortiz, M., Scapelatto, P., Bottaro, E., Murano, F., Miachans, M., Contarelli, J., Massera, L., Corral, J., Hualde, M., Miglioranza, C., Corti, M., Metta, H., Casiro, A., Cuini, R., Laplume, H., David, D., Marson, C., Lupo, S., Trape, L., Garcia Messina, O., Gear, O., Bruguera, J. M., Karpov, I., Skrahina, E., Skrahin, A., Zhavoronok, S., Mitsura, V., Ruzanov, D., Bondarenko, V., Suetnov, O., Paduto, D., Gerstoft, J., Kronborg, G., Pedersen, C., Larsen, C. S., Pedersen, G., Laursen, A. L., Nielsen, L., Jensen, J., Dabis, F., Chene, G., Lawson-Ayayi, S., Thiebaut, R., Wittkop, L., Morlat, P., Bonnet, F., Bernard, N., Hessamfar, M., Lacoste, D., Vandenhende, M. A., Dupon, M., Dauchy, F. A., Dutronc, H., Longy-Boursier, M., Mercie, P., Duffau, P., Roger Schmeltz, J., Malvy, D., Pistone, T., Receveur, M. C., Neau, D., Cazanave, C., Ochoa, A., Vareil, M. O., Pellegrin, J. L., Viallard, J. F., Greib, C., Lazaro, E., Fleury, H., Lafon, M. E., Reigadas, S., Trimoulet, P., Breilh, D., Molimard, M., Bouchet, S., Titier, K., Moreau, J. F., Pellegrin, I., Haramburu, F., Arcachon, G., Dupont, A., Gerard, Y., Caunegre, L., Andre, K., Bonnal, F., Farbos, S., Gemain, M. C., Ceccaldi, J., Tchamgoue, S., De Witte, S., Courtault, K., Monlun, E., Gaborieau, V., Lataste, P., Meraud, J. P., Chossat, I., Carvalho, A. C., Basche, R., Hamad, I. E., Ricci, B. A., Maggiolo, F., Ravasio, V., Mussini, C., Prati, F., Castelletti, S., Ammassari, A., Antinori, A., Bellagamba, R., Busi Rizzi, E., Cicalini, S., Corpolongo, A., Capaldo, A., Di Caro, A., Goletti, D., Grisetti, S., Gualano, G., Lauria, F. N., Parracino, L., Palmieri, F., Petrosillo, N., Pinetti, C., Sampaolesi, A., Moroni, M., Angarano, G., Armignacco, O., d'Arminio Monforte, A., Castelli, F., Cauda, R., Di Perri, G., Galli, M., Iardino, R., Guzzinati, Ippolito, Lazzarin, A., Perno, C. F., von Schloesser, F., Viale, P., Castagna, A., Ceccherini-Silberstein, F., Cozzi-Lepri, A., Lo Caputo, S., Puoti, M., Andreoni, M., Balotta, C., Bonfanti, P., Bonora, S., Borderi, M., Capobianchi, M. R., Cingolani, A., Cinque, P., De Luca, A., Di Biagio, A., Gianotti, N., Gori, A., Guaraldi, G., Lapadula, G., Lichtner, M., Madeddu, G., Marchetti, G., Marcotullio, S., Monno, L., Quiros Roldan, E., Rusconi, S., Cicconi, P., Fanti, I., Formenti, T., Galli, L., Lorenzini, P., Giacometti, A., Costantini, A., Carrisa, C., Suardi, C., Vanino, E., Verucchi, G., Minardi, C., Quirino, T., Abeli, C., Manconi, P. E., Piano, P., Vecchiet, J., Falasca, K., Sighinolfi, L., Segala, D., Mazzotta, F., Cassola, G., Viscoli, G., Alessandrini, A., Piscopo, R., Mazzarello, G., Mastroianni, C., Belvisi, V., Caramma, I., Castelli, A. P., Rizzardini, G., Ridolfo, A. L., Piolini, R., Salpietro, S., Carenzi, L., Moioli, M. C., Puzzolante, C., Abrescia, N., Chirianni, A., Guida, M. G., Gargiulo, M., Baldelli, F., Francisci, D., Parruti, G., Ursini, T., Magnani, G., Ursitti, M. A., Vullo, V., D'Avino, A., Gallo, L., Nicastri, E., Acinapura, R., Capozzi, M., Libertone, R., Tebano, G., Cattelan, A., Mura, M. S., Caramello, P., Orofino, G. C., Sciandra, M., Pellizzer, G., Manfrin, V., Riekstina, V., Aldins, P., Duiculescu, D., Malashenkov, E., Kozlov, A., Buzunova, S., Garcia-Goez, J. F., Moreno Camacho, A., Martinez, J. A., Gonzalez, J., Garcia-Alcaide, F., de Lazzari, E., Gatell, J. M., Sanchez, P., Lopezcolomes, J. L., Martinez-Lacasa, X., Falco, V., Imaz, A., Ocana, I., Vidal, R., Sambeat, M. A., Moreno-Martinez, A., Orcau, A., Weber, R., Battegay, M., Hirschel, B., Cavassini, M., Bernasconi, E., Schmid, P., Rickenbach, M., Campbell, L., Arenas-Pinto, A., Chentsova, N., Kjaer, J., Efsen, Anne Marie W., Panteleev, Alexander M., Grint, Daniel, Podlekareva, Daria N., Vassilenko, Anna, Rakhmanova, Aza, Zeltina, Indra, Losso, Marcelo H., Miller, Robert F., Girardi, Enrico, Caylã¡, Joan, Post, Frank A., Miro, Jose M., Bruyand, Mathia, Furrer, Hansjakob, Obel, Niel, Lundgren, Jens D., Mocroft, Amanda, Kirk, Ole, Hiv/tb Study, Group, Castagna, Antonella, Efsen, A, Panteleev, A, Grint, D, Podlekareva, D, Vassilenko, A, Rakhmanova, A, Zeltina, I, Losso, M, Miller, R, Girardi, E, Caylá, J, Post, F, Miro, J, Bruyand, M, Furrer, H, Obel, N, Lundgren, J, Mocroft, A, Kirk, O, and Gori, A
Subjects: Genetics and Molecular Biology (all), Male, Pediatrics, Meningeal, Immunology and Microbiology (all), lcsh:Medicine, HIV Infections, Kaplan-Meier Estimate, Rate ratio, Biochemistry, Risk Factors, Adult, Argentina, CD4 Lymphocyte Count, Europe, Female, HIV, Humans, Treatment Outcome, Tuberculosis, Meningeal, Biochemistry, Genetics and Molecular Biology (all), HIV Infection, Mortality rate, General Medicine, symbols, Meningitis, Human, Research Article, medicine.medical_specialty, Tuberculosis, Settore MED/17 - Malattie Infettive, Article Subject, General Biochemistry, Genetics and Molecular Biology, Tuberculous meningitis, NO, symbols.namesake, Pharmacotherapy, medicine, Poisson regression, General Immunology and Microbiology, business.industry, Public health, Risk Factor, lcsh:R, medicine.disease, Immunology, business
Abstract: Objectives.The study aimed at describing characteristics and outcome of tuberculous meningitis (TBM) in HIV-positive patients and comparing these parameters with those of extrapulmonary TB (TBEP) and pulmonary TB (TBP).Methods.Kaplan-Meier estimation and Poisson regression models were used to assess the mortality following TB diagnosis and to evaluate potential prognostic factors for the 3 groups of TB patients separately.Results.A total of 100 patients with TBM, 601 with TBEP, and 371 TBP were included. Patients with TBM had lower CD4 cell counts and only 17.0% received antiretroviral therapy (ART) at TB diagnosis. The cumulative probability of death at 12 months following TB was 51.2% for TBM (95% CI 41.4–61.6%), 12.3% for TBP (8.9–15.7%), and 19.4% for TBEP (16.1–22.6) (P<0.0001; log-rank test). For TBM, factors associated with a poorer prognosis were not being on ART (adjusted incidence rate ratio (aIRR) 4.00 (1.72–9.09), a prior AIDS diagnosis (aIRR=4.82(2.61–8.92)), and receiving care in Eastern Europe (aIRR=5.41(2.58–11.34))).Conclusions.TBM among HIV-positive patients was associated with a high mortality rate, especially for patients from Eastern Europe and patients with advanced HIV-infection, which urgently calls for public health interventions to improve both TB and HIV aspects of patient management.
Published: 2013
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207. Overlapping structure of HBV genome and immune selection pressure are critical forces modulating HBV evolution

Author: Cento, V, Mirabelli, C, Dimonte, S, Salpini, R, Han, Y, Trimoulet, P, Bertoli, A, Micheli, V, Gubertini, G, Cappiello, G, Spano, A, Longo, R, Bernassola, M, Mazzotta, F, De Sanctis, G, Zhang, X, Verheyen, J, D'Arminio Monforte, A, CECCHERINI SILBERSTEIN, F, Perno, Cf, and Svicher, V
Subjects: Settore MED/07 - Microbiologia e Microbiologia Clinica
Published: 2012

208. Role of serum free light chains in predicting HIV-associated non-Hodgkin lymphoma and Hodgkin's lymphoma and its correlation with antiretroviral therapy

Author: Bibas, M, Trotta, Mp, Cozzi Lepri, A, Lorenzini, P, Pinnetti, C, Rizzardini, G, Angarano, G, Caramello, P, Sighinolfi, L, Mastroianni, Cm, Mazzarello, G, Di Caro, A, Di Giacomo, C, d'Arminio Monforte, A, Antinori, A, Collaborators: Moroni M, ICONA Foundation Study G. r. o. u. p., Carosi, G, Cauda, R, Chiodo, F, Di Perri, G, Galli, M, Iardino, R, Ippolito, G, Lazzarin, A, Panebianco, R, Pastore, G, Perno, Cf, Ammassari, A, Arici, C, Balotta, C, Bonfanti, P, Capobianchi, Mr, Castagna, A, Ceccherini Silberstein, F, De Luca, A, Gervasoni, C, Girardi, E, Lo Caputo, S, Murri, R, Mussini, C, Puoti, M, Torti, Carlo, Montroni, M, Costantini, A, Frontini, F, Giacometti, A, Riva, A, Carrisa, C, Maggiolo, F, Lazzari, G, Viale, P, Verucchi, G, Vanini, E, Torti, C, Minardi, C, Quirino, T, Abeli, C, Manconi, Pe, Piano, P, Vecchiet, J, Falasca, K, Sighinolﬁ, L, Segala, D, Mazzotta, F, Cassola, G, Piscopo, R, Viscoli, C, Alessandrini, A, Mastroianni, C, Belvisi, V, Caremma, I, Chiodera, A, Castelli, P, Ridolfo, A, Piolini, R, Zucchi, P, Formenti, T, Salpietro, S, Moioli, C, Esposito, R, Bisio, L, Gori, A, Lapadula, G, Chirianni, A, Abrescia, N, De Marco, M, Baldelli, F, Belﬁori, B, Parruti, G, Sozio, F, Magnani, G, Ursitti, M, Marzocchetti, A, Narciso, P, Gallo, L, Acinapura, R, Vullo, V, Lichtner, M, Tebano, G, Andreoni, M, Capozzi, M, Tozzi, V, Libertone, R, Cerilli, S, Cattelan, Am, Mura, Ms, Madeddu, G, Bonora, S, Sciandra, M, Guastavigna, M, Pellizzer, G, and Manfrin, V.
Published: 2012

209. Performance of genotypic tropism testing on proviral DNAin clinical practice: results from the DIVA Study Group

Author: Svicher, V, Alteri, C, Montano, M, D'Arrigo, R, Andreoni, M, Angarano, G, Antinori, A, Antonelli, G, Allice, T, Bagnarelli, P, Baldanti, F, Bertoli, A, Borderi, M, Boeri, E, Bon, I, Bruzzone, B, Callegaro, Ap, Capobianchi, Mr, Carosi, G, Cauda, R, Ceccherini Silberstein, F, Clementi, M, Chirianni, A, Colafigli, M, D'Arminio Monforte, A, De Luca, A, Di Biagio, A, Di Nicuolo, G, Di Perri, G, Di Pietro, M, Di Santo, F, Fabeni, L, Fadda, G, Galli, M, Gennari, W, Ghisetti, V, Giacometti, A, Gori, C, Gori, A, Gulminetti, R, Leoncini, F, Maffongelli, G, Maggiolo, F, Manca, G, Gargiulo, F, Martinelli, C, Maserati, R, Mazzotta, F, Meini, G, Micheli, V, Monno, L, Mussini, C, Narciso, P, Nozza, S, Paolucci, S, Pal, G, Parisi, S, Parruti, G, Pignataro, Ar, Pollicita, M, Quirino, T, Re, Mc, Rizzardini, G, Santangelo, R, Scaggiante, R, Sterrantino, G, Turriziani, O, Vatteroni, Ml, Vecchi, L, Viscoli, Claudio, Vullo, V, Zazzi, M, Lazzarini, A, and Perno, Cf
Subjects: HIV, Proviral DNA, Tropism
Published: 2012

210. Viral tropism by geno2pheno as a tool for predicting CD4 decrease in HIV-1-infected naive patients with high CD4 counts

Author: Nozza, S, Canducci, F, Galli, L, Cozzi Lepri, A, Capobianchi, Mr, Ceresola, Er, Narciso, P, Libertone, R, Castelli, P, Moioli, M, D'Arminio Monforte, A, Castagna, A, Collaborators: Moroni M, ICONA F. o. u. n. d. a. t. i. o. n., Carosi, Giampiero, Cauda, R, Chiodo, F, d'Arminio Monforte, A, Di Perri, G, Galli, M, Iardino, R, Ippolito, G, Lazzarin, A, Panebianco, R, Pastore, G, Perno, C, Ammassari, A, Antinori, A, Arici, C, Balotta, C, Bonfanti, P, Capobianchi, M, Ceccherini Silberstein, F, De Luca, A, Gervasoni, C, Girardi, E, Lo Caputo, S, Murri, R, Mussini, C, Puoti, M, Torti, Carlo, Montroni, M, Scalise, G, Braschi, M, Riva, A, Tirelli, U, Martellotta, F, Ladisa, N, Suter, F, Colangeli, V, Fiorini, C, Coronado, O, Carosi, G, Cristini, G, Torti, C, Minardi, C, Bertelli, D, Quirino, T, Manconi, P, Piano, P, Pizzigallo, E, D'Alessandro, M, Ghinelli, F, Sighinolfi, L, Leoncini, F, Mazzotta, F, Pozzi, M, Grisorio, B, Ferrara, S, Pagano, G, Cassola, G, Alessandrini, A, Piscopo, R, Soscia, F, Tacconi, L, Orani, A, Perini, P, Chiodera, F, Moroni, M, Rizzardini, G, Caggese, L, Galli, A, Merli, S, Pastecchia, C, Esposito, R, Abrescia, N, Chirianni, A, De Marco, M, Viglietti, R, Ferrari, C, Pizzaferri, P, Filice, G, Bruno, R, Magnani, G, Ursitti, M, Arlotti, M, Ortolani, P, Antonucci, G, Vullo, V, Zaccarelli, M, Acinapura, R, De Longis, P, Trotta, M, Lichtner, M, Carletti, F, Mura, M, Mannazzu, M, Caramello, P, Orofino, G, Sciandra, M, Raise, E, Ebo, F, Pellizzer, G, and Buonfrate, D.
Published: 2012

211. Key genetic elements in HIV-1 gp120 V1,V2 and C4 domains tightly and differentially modulate gp120 interaction with the CCR5 and CXCR4 N terminus and HIV-1 antigenetic Potential

Author: Svicher, V, Chen, M, Alteri, C, Costa, G, Dimonte, S, Chang, L, Parrotta, L, Dimaio, C, Surdo, M, Saccomandi, P, Alcaro, S, CECCHERINI SILBERSTEIN, F, Artese, A, Zhang, J, and Perno, Cf
Subjects: Settore MED/07 - Microbiologia e Microbiologia Clinica
Published: 2011

212. Evaluation of glomerular filtration rate in HIV-1-infected patients before and after combined antiretroviral therapy exposure

Author: Tordato, F, Cozzi Lepri, A, Cicconi, P, De Luca, A, Antinori, A, Colangeli, V, Castagna, A, Nasta, P, Ladisa, N, Giacometti, A, d'Arminio Monforte, A, Gori, A, ICONA Foundation Study Group: Ammassari, A, Arici, C, Balotta, C, Bonfanti, P, Capobianchi, Mr, Ceccherini Silberstein, F, Gervasoni, C, Girardi, E, Lo Caputo, S, Murri, R, Mussini, C, Puoti, M, Torti, Carlo, Montroni, M, Scalise, G, Braschi, Mc, Riva, A, Tirelli, U, Martellotta, F, Pastore, G, Suter, F, Chiodo, F, Fiorini, C, Coronado, O, Carosi, G, Cristini, G, Torti, C, Minardi, C, Bertelli, D, Quirino, T, Manconi, Pe, Piano, P, Pizzigallo, E, D'Alessandro, M, Ghinelli, F, Sighinolfi, L, Leoncini, F, Mazzotta, F, Pozzi, M, Grisorio, B, Ferrara, S, Pagano, G, Cassola, G, Alessandrini, A, Piscopo, R, Soscia, F, Tacconi, L, Orani, A, Perini, P, Chiodera, F, Castelli, P, Moroni, M, Lazzarin, A, Rizzardini, G, Caggese, L, Galli, A, Merli, S, Pastecchia, C, Moioli, Mc, Esposito, R, Abrescia, N, Chirianni, A, De Marco, M, Viglietti, R, Ferrari, C, Pizzaferri, P, Filice, G, Bruno, R, Magnani, G, Ursitti, Ma, Arlotti, M, Ortolani, P, Cauda, R, Antonucci, G, Narciso, P, Vullo, V, Zaccarell, M, Acinapura, R, De Longis, P, Trotta, Mp, Lichtner, M, Carletti, F, Mura, Ms, Mannazzu, M, Caramello, P, Di Perri, G, Orofino, Gc, Sciandra, M, Raise, E, Ebo, F, Pellizzer, G, and Buonfrate, D.
Published: 2011

213. Prevalence of hypovitaminosis D and factors associated with vitamin D deficiency and morbidity among HIV-infected patients enrolled in a large Italian cohort

Author: Vescini, F, Cozzi Lepri, A, Borderi, M, Re, Mc, Maggiolo, F, De Luca, A, Cassola, G, Vullo, V, Carosi, Giampiero, Antinori, A, Tozzi, V, Monforte, Ad, Icona Foundation Study Group: Moroni, M, Angarano, G, Carosi, G, Cauda, R, d'Arminio Monforte, A, Di Perri, G, Galli, M, Iardino, R, Ippolito, G, Lazzarin, A, Perno, Cf, Viale, Pl, Von Schlosser, F, Ammassari, A, Andreoni, M, Balotta, C, Bonfanti, P, Bonora, S, Capobianchi, Mr, Castagna, A, Ceccherini Silberstein, F, Gargiulo, M, Gervasoni, C, Girardi, E, Lichtner, M, Lo Caputo, S, Madeddu, G, Marcotullio, S, Monno, L, Murri, R, Mussini, C, Puoti, M, Torti, Carlo, Fanti, I, Formenti, T, Montroni, M, Giacometti, A, Costantini, A, Riva, A, Tirelli, U, Martellotta, F, Ladisa, N, Suter, F, Verucchi, G, Piergentili, B, Cristini, G, Torti, C, Minardi, C, Bertelli, D, Quirino, T, Abeli, C, Manconi, Pe, Piano, P, Vecchiet, J, Falasca, K, Carnevale, G, Lorenzotti, S, Sighinolfi, L, Leoncini, F, Mazzotta, F, Pozzi, M, Viscoli, G, Alessandrini, A, Piscopo, R, Mazzarello, G, Mastroianni, C, Belvisi, V, Molteni, C, Chiodera, A, Castelli, P, Rizzardini, G, Ridolfo, Al, Foschi, A, Salpietro, S, Merli, S, Carenzi, L, Moioli, Mc, Cicconi, P, Esposito, R, Gori, A, Pastore, V, Abrescia, N, Chirianni, A, De Marco, M, Ferrari, C, Borghi, R, Baldelli, F, Belfiori, B, Parruti, G, Sozio, F, Magnani, G, Ursitti, Ma, Emilia, R, Arlotti, M, Ortolani, P, Antonucci, G, Narciso, P, Zaccarelli, M, Gallo, L, Acinapura, R, De Longis, P, Ceccarelli, L, Libertone, R, Trotta, Mp, Miccoli, A, Cattelan, Am, Mura, Ms, Caramello, P, Orofino, Gc, Sciandra, M, Raise, E, Ebo, F, Pellizzer, G, and Buonfrate, D.
Published: 2011

214. Microbial translocation predicts disease progression of HIV-infected antiretroviral-naive patients with high CD4+ cell count

Author: Marchetti, G, Cozzi Lepri, A, Merlini, E, Bellistrì, Gm, Castagna, A, Galli, M, Verucchi, G, Antinori, A, Costantini, A, Giacometti, A, di Caro, A, D'arminio Monforte, A, ICONA Foundation Study Group: Moroni, M, Angarano, G, Carosi, G, Cauda, R, d'Arminio Monforte, A, Di Perri, G, Iardino, R, Ippolito, G, Lazzarin, A, Perno, Cf, Viale, Pl, Von Schlosser, F, Ammassari, A, Andreoni, M, Balotta, C, Bonfanti, P, Bonora, S, Borderi, M, Capobianchi, Mr, Ceccherini Silberstein, F, De Luca, A, Gargiulo, M, Gervasoni, C, Girardi, E, Lichtner, M, Lo Caputo, S, Madeddu, G, Maggiolo, F, Marcotullio, S, Monno, L, Murri, R, Mussini, C, Puoti, M, Torti, Carlo, Fanti, I, Formenti, T, Montroni, M, Riva, A, Tirelli, U, Martellotta, F, Ladisa, N, Suter, F, Piergentili, B, Cristini, G, Torti, C, Minardi, C, Bertelli, D, Quirino, T, Abeli, C, Manconi, Pe, Piano, P, Vecchiet, J, Falasca, K, Carnevale, G, Lorenzotti, S, Sighinolfi, L, Leoncini, F, Mazzotta, F, Pozzi, M, Cassola, G, Viscoli, G, Alessandrini, A, Piscopo, R, Mazzarello, G, Mastroianni, C, Belvisi, V, Molteni, C, Chiodera, A, Castelli, P, Rizzardini, G, Ridolfo, Al, Foschi, A, Salpietro, S, Merli, S, Carenzi, L, Moioli, Mc, Cicconi, P, Esposito, R, Gori, A, Pastore, V, Abrescia, N, Chirianni, A, De Marco, M, Ferrari, C, Borghi, R, Baldelli, F, Belfiori, B, Parruti, G, Sozio, F, Magnani, G, Ursitti, Ma, Emilia, R, Arlotti, M, Ortolani, P, Antonucci, G, Narciso, P, Tozzi, V, Vullo, V, Zaccarelli, M, Gallo, L, Acinapura, R, De Longis, P, Ceccarelli, L, Libertone, R, Trotta, Mp, Miccoli, A, Cattelan, Am, Mura, Ms, Caramello, P, Orofino, Gc, Sciandra, M, Raise, E, Ebo, F, Pellizzer, G, and Buonfrate, D.
Published: 2011

215. Evaluation of glomerular filtration rate in HIV-1-infected patients before and after combined antiretroviral therapy exposure

Author: Tordato, F1, Cozzi Lepri, A, Cicconi, P, De Luca, A, Antinori, A, Colangeli, V, Castagna, A, Nasta, P, Ladisa, N, Giacometti, A, d'Arminio Monforte, A, Gori, A, Collaborators Ammassari A, ICONA Foundation Study G. r. o. u. p., Arici, C, Balotta, C, Bonfanti, P, Capobianchi, Mr, Ceccherini Silberstein, F, Gervasoni, C, Girardi, E, Lo Caputo, S, Murri, R, Mussini, C, Puoti, M, Torti, C, Montroni, M, Scalise, G, Braschi, Mc, Riva, A, Tirelli, U, Martellotta, F, Pastore, G, Suter, F, Chiodo, F, Fiorini, C, Coronado, O, Carosi, G, Cristini, G, Minardi, C, Bertelli, D, Quirino, T, Manconi, Pe, Piano, P, Pizzigallo, E, D'Alessandro, M, Ghinelli, F, Sighinolfi, L, Leoncini, F, Mazzotta, F, Pozzi, M, Grisorio, B, Ferrara, S, Pagano, G, Cassola, G, Alessandrini, A, Piscopo, R, Soscia, F, Tacconi, L, Orani, A, Perini, P, Chiodera, F, Castelli, P, Moroni, M, Lazzarin, A, Rizzardini, G, Caggese, L, Galli, A, Merli, S, Pastecchia, C, Moioli, Mc, Esposito, R, Abrescia, N, Chirianni, A, De Marco, M, Viglietti, R, Ferrari, C, Pizzaferri, P, Filice, G, Bruno, R, Magnani, G, Ursitti, Ma, Arlotti, M, Ortolani, P, Cauda, R, Antonucci, G, Narciso, P, Vullo, Vincenzo, Zaccarell, M, Acinapura, R, De Longis, P, Trotta, Mp, Carletti, F, Mura, Ms, Mannazzu, M, Caramello, P, Di Perri, G, Orofino, Gc, Sciandra, M, Raise, E, Ebo, F, Pellizzer, G, and Buonfrate, D.
Published: 2011

216. HIV-1 R5+ /X4- tropic viruses can be inhibited in vitro as well as in vivo by maraviroc: a refined analysis of patients enrolled in the Phase IIb study A4001029

Author: CECCHERINI SILBERSTEIN, F, Surdo, M, Alteri, C, Puertas, M, Saccomandi, P, Artese, A, Balestra, E, Chapman, D, Lewis, M, Valdez, H, Clotet, B, Alcaro, S, Santoro, M, Svicher, V, Martinez Picado, J, and Perno, Cf
Subjects: Settore MED/07 - Microbiologia e Microbiologia Clinica
Published: 2011

217. The Lowest X4 Geno2Pheno-False Positive Rate Is Associated with Greater CD4-Depletion

Author: Santoro, M. M., Armenia, D., Fabeni, L., Santoro, M., Gori, C., Forbici, F., Valeria Cento, Svicher, V., Bertoli, A., Dori, L., Andreoni, M., Narciso, P., Antinori, A., Ceccherini-Silberstein, F., and Perno, C. F.
Subjects: Settore MED/07 - Microbiologia e Microbiologia Clinica
Published: 2011

218. Signature mutations in V3 and bridging sheet domain of HIV-1 gp120 are specifically associated with dual tropism and modulate the interaction with CCR5 N-terminus

Author: Alteri, C, Artese, A, Zang, J, Mercurio, F, Costa, G, Stazi, F, Fabeni, L, Bertoli, A, Forbici, F, Salpini, R, Dimonte, S, Alcaro, S, CECCHERINI SILBERSTEIN, F, Perno, Cf, and Svicher, V
Subjects: Settore MED/07 - Microbiologia e Microbiologia Clinica
Published: 2011

219. The Genotypic False Positive Rate Determined by Population V3-Sequencing can Predict the Burden of X4 Quasispecies Detected by Pyrosequencing

Author: Cento, V, Svicher, V, Rozera, G, Abbate, I, Santoro, M, Armenia, D, Fabeni, L, Palamara, G, Latini, A, Rizzardini, G, Micheli, V, Buonomini, A, Antinori, A, Andreoni, M, Perno, Cf, Capobianchi, M, and CECCHERINI SILBERSTEIN, F
Subjects: Settore MED/07 - Microbiologia e Microbiologia Clinica
Published: 2011

220. Specific HBSAG Genetic- Determinants are associated with occult HBV-infection in vivo and HBSAG detection

Author: Svicher, V, Cento, V, Bernassola, M, Neumann Fraune, M, Salpini, R, Longo, R, Visca, M, Romano, S, Michieli, V, Bertoli, A, Gubertini, G, Marino, N, Mazzotta, F, Sarrecchia, C, Andreoni, M, Angelico, M, Ursitti, A, Spanò, A, CECCHERINI SILBERSTEIN, F, Verheyen, J, Cappiello, G, and Perno, Cf
Subjects: Settore MED/07 - Microbiologia e Microbiologia Clinica
Published: 2011

221. Dual mixed (but not X4) tropic-HIV-1 isolates can replicate in human primary macrophages and are inhibited by CCR5- inhibitors

Author: Surdo, M, Balestra, E, Saccomandi, P, Di Santo, F, Svicher, V, Alteri, C, Cento, V, Pollicita, M, Scopelliti, F, Andreoni, M, Aquaro, S, CECCHERINI SILBERSTEIN, F, and Perno, Cf
Subjects: Settore MED/07 - Microbiologia e Microbiologia Clinica
Published: 2011

222. HCV NS3 sequencing as a reliable and clinically useful tool for the assessment of genotype and resistance mutations for clinical samples with different HCV-RNA levels

Author: Di Maio, V. C., primary, Cento, V., additional, Di Paolo, D., additional, Aragri, M., additional, De Leonardis, F., additional, Tontodonati, M., additional, Micheli, V., additional, Bellocchi, M. C., additional, Antonucci, F. P., additional, Bertoli, A., additional, Lenci, I., additional, Milana, M., additional, Gianserra, L., additional, Melis, M., additional, Di Biagio, A., additional, Sarrecchia, C., additional, Sarmati, L., additional, Landonio, S., additional, Francioso, S., additional, Lambiase, L., additional, Nicolini, L. A., additional, Marenco, S., additional, Nosotti, L., additional, Giannelli, V., additional, Siciliano, M., additional, Romagnoli, D., additional, Pellicelli, A., additional, Vecchiet, J., additional, Magni, C. F., additional, Babudieri, S., additional, Mura, M. S., additional, Taliani, G., additional, Mastroianni, C., additional, Vespasiani-Gentilucci, U., additional, Romano, M., additional, Morisco, F., additional, Gasbarrini, A., additional, Vullo, V., additional, Bruno, S., additional, Baiguera, C., additional, Pasquazzi, C., additional, Tisone, G., additional, Picciotto, A., additional, Andreoni, M., additional, Parruti, G., additional, Rizzardini, G., additional, Angelico, M., additional, Perno, C. F., additional, and Ceccherini-Silberstein, F., additional
Published: 2015
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223. P0903 : Slow HCV kinetics following sofosbuvir + ribavirin administration in real-life setting of liver transplant recipients with severe recurrent hepatitis C

Author: Cento, V., primary, Donato, M.F., additional, Lenci, I., additional, Rendina, M., additional, Milana, M., additional, Di Maio, V.C., additional, Monico, S., additional, Aragri, M., additional, Alfieri, R., additional, Abedrabbo, A., additional, Sforza, D., additional, Manuelli, M., additional, Mameli, L., additional, Sorbo, M.C., additional, Canu, R., additional, Ponti, M.L., additional, Chialà, C., additional, Malinverno, F., additional, Marenco, S., additional, Milanesi, L., additional, Picciotto, A., additional, Rossi, G., additional, Di Leo, A., additional, Tisone, G., additional, Zamboni, F., additional, Ganga, R., additional, Colombo, M., additional, Perno, C.F., additional, Angelico, M., additional, and Ceccherini-Silberstein, F., additional
Published: 2015
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224. P0915 : Clinical relevance of baseline/early detection and persistence of resistant associated variants in HCV-1 patients treated with protease-inhibitors assessed by ultra-deep sequencing

Author: Di Maio, V.C., primary, Armenia, D., additional, Bellocchi, M.C., additional, Di Paolo, D., additional, Cento, V., additional, Tontodonati, M., additional, Micheli, V., additional, Carioti, L., additional, De Leonardis, F., additional, Aragri, M., additional, Polilli, E., additional, Manunta, A., additional, Magni, C., additional, Antonucci, F.P., additional, De Luca, F., additional, Sarrecchia, C., additional, Bertoli, A., additional, Lenci, I., additional, Francioso, S., additional, Santoro, M.M., additional, Vecchiet, J., additional, De Maria, A., additional, Picciotto, A., additional, Nosotti, L., additional, Morisco, F., additional, Bruno, S., additional, Puoti, M., additional, Babudieri, S., additional, Mura, M.S., additional, Taliani, G., additional, Andreoni, M., additional, Rizzardini, G., additional, Parruti, G., additional, Angelico, M., additional, Perno, C.F., additional, and Ceccherini-Silberstein, F., additional
Published: 2015
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225. P0912 : Early-phase HCV kinetics and role of pre-existing resistance in cirrhotic or interferon-insensitive patients on daclatasvir plus asunaprevir

Author: Cento, V., primary, Calvaruso, V., additional, Marenco, S., additional, Alfieri, R., additional, Aragri, M., additional, Antonucci, F.P., additional, Di Maio, V.C., additional, Petta, S., additional, Mazzola, A., additional, Milanesi, L., additional, Picciotto, A., additional, Ceccherini-Silberstein, F., additional, Craxì, A., additional, and Perno, C.F., additional
Published: 2015
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226. P0614 : Key HBsAg mutations significantly correlate with HCC, hamper HBsAg secretion and promote cell proliferation in vitro

Author: Surdo, M., primary, Salpini, R., additional, Warner, N., additional, Cortese, M.F., additional, Mirabelli, C., additional, Colledge, D., additional, Soppe, S., additional, Pollicita, M., additional, Longo, R., additional, Romano, S., additional, Cappiello, G., additional, Spanò, A., additional, Trimoulet, P., additional, Fleury, H., additional, Vecchiet, J., additional, Iapadre, N., additional, Barlattani, A., additional, Bertoli, A., additional, Mari, T., additional, Pasquazzi, C., additional, Missale, G., additional, Sarrecchia, C., additional, Orecchini, E., additional, Michienzi, A., additional, Andreoni, M., additional, Francioso, S., additional, Angelico, M., additional, Ceccherini-Silberstein, F., additional, Locarnini, S., additional, Perno, C.-F., additional, and Svicher, V., additional
Published: 2015
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227. Clinical relevance of next generation sequencing on baseline detection of minority resistance associated variants in HCV-1 patients treated with protease inhibitors

Author: Armenia, D., primary, Carioti, L., additional, Di Maio, V.C., additional, Bellocchi, M.C., additional, Di Paolo, D., additional, Guerrieri, F., additional, Calvo, L., additional, Cento, V., additional, Tontodonati, M., additional, Micheli, V., additional, De Leonardis, F., additional, Aragri, M., additional, Polilli, E., additional, Manunta, A., additional, Magni, C., additional, Antonucci, F.P., additional, De Luca, F., additional, Sarrecchia, C., additional, Bertoli, A., additional, Lenci, I., additional, Francioso, S., additional, Santoro, M.M., additional, Vecchiet, J., additional, Marenco, S., additional, Picciotto, A., additional, Nosotti, L., additional, Morisco, F., additional, Bruno, S., additional, Puoti, M., additional, Babudieri, S., additional, Mura, M.S., additional, Andreoni, M., additional, Rizzardini, G., additional, Parruti, G., additional, Levrero, M., additional, Angelico, M., additional, Perno, C.F., additional, and Ceccherini-Silberstein, F., additional
Published: 2015
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228. Slow achievement of HCV-RNA undetectability in cirrhotic patients treated with sofosbuvir+ribavirin: possible clinical implications in the liver transplant list management

Author: Lenci, I., primary, Cento, V., additional, Rendina, M., additional, Donato, M.F., additional, Milana, M., additional, Sforza, D., additional, Manuelli, M., additional, Aragri, M., additional, Di Maio, V.C., additional, Abedrabbo, A., additional, Castellaneta, A., additional, Malinverno, F., additional, Monico, S., additional, Ponti, M.L., additional, Canu, R., additional, Ganga, R., additional, Alfieri, R., additional, Milanesi, L., additional, Di Leo, A., additional, Tisone, G., additional, Perno, C.F., additional, Ceccherini-Silberstein, F., additional, Colombo, M., additional, and Angelico, M., additional
Published: 2015
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229. Effect of maraviroc on non-R5 tropic HIV-1: refined analysis of subjects from the phase IIb study A4001029

Author: Surdo, M., primary, Alteri, C., additional, Puertas, M.C., additional, Saccomandi, P., additional, Parrotta, L., additional, Swenson, L., additional, Chapman, D., additional, Costa, G., additional, Artese, A., additional, Balestra, E., additional, Aquaro, S., additional, Alcaro, S., additional, Lewis, M., additional, Clotet, B., additional, Harrigan, R., additional, Valdez, H., additional, Svicher, V., additional, Perno, C.F., additional, Martinez-Picado, J., additional, and Ceccherini-Silberstein, F., additional
Published: 2015
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230. Incidence of malignancies in HIV-infected patients and prognostic role of current CD4 cell count: evidence from a large Italian cohort study

Author: Prosperi, Mc, Cozzi Lepri, A, Castagna, A, Mussini, C, Murri, R, Giacometti, A, Torti, Carlo, Costantini, A, Narciso, P, Ghinelli, F, Antinori, A, d'Arminio Monforte, A, Icona Foundation Study Group, Moroni, M, Carosi, Giampiero, Cauda, R, Di Perri, G, Galli, M, Iardino, R, Ippolito, G, Lazzarin, A, Mazzotta, F, Panebianco, R, Pastore, G, Perno, Cf, Ammassari, A, Arici, C, Balotta, C, Bonfanti, P, Capobianchi, Mr, Ceccherini Silberstein, F, De Luca, A, Gervasoni, C, Girardi, E, Lo Caputo, S, Maggiolo, F, Puoti, Massimo, Torti, C, Fanti, I, Formenti, T, Montroni, M, Riva, A, Tirelli, U, Martellotta, F, Ladisa, N, Pierri, A, Suter, F, Borderi, M, Verucchi, G, Piergentili, B, Carosi, G, Cristini, G, Minardi, C, Bertelli, D, Quirino, D, Abeli, C, Manconi, Pe, Piano, P, Vecchiet, J, Falasca, K, Carnevale, G, Lorenzotti, S, Sighinolfi, L, Leoncini, F, Pozzi, M, Pagano, G, Cassola, G, Viscoli, G, Alessandrini, A, Piscopo, R, Mazzarello, G, Soscia, F, Tacconi, L, Orani, A, Rossotti, R, Tommasi, D, Congedo, P, Chiodera, A, Castelli, P, Rizzardini, G, Schlacht, I, Ridolfo, Al, Foschi, A, Salpietro, S, Merli, S, Melzi, S, Moioli, Mc, Cicconi, P, Esposito, R, Gori, A, Fiorino, M, Abrescia, N, Chirianni, A, Izzo, Cm, De Marco, M, Viglietti, R, Manzillo, E, Ferrari, C, Pizzaferri, P, Baldelli, F, Belfiori, B, Magnani, G, Ursitti, Ma, Arlotti, M, Ortolani, P, Andreoni, M, Antonucci, G, Tozzi, V, Vullo, V, Zaccarelli, M, Acinapura, R, De Longis, P, Trotta, Mp, Calbi, M, Gallo, L, Miccoli, A, Carletti, F, Mura, Ms, Madeddu, G, Caramello, P, Orofino, Gc, Sciandra, M, Raise, E, Ebo, F, Pellizzer, G, and Buonfrate, D.
Published: 2010

231. Insights into reasons for discontinuation according to year of starting first regimen of highly active antiretroviral therapy in a cohort of antiretroviral-naïve patients

Author: Cicconi, P, Cozzi Lepri, A, Castagna, A, Trecarichi, Em, Antinori, A, Gatti, F, Cassola, G, Sighinolfi, L, Castelli, P, d'Arminio Monforte, A, Collaborators: Moroni M, ICoNA Foundation Study G. r. o. u. p., Carosi, G, Cauda, R, Chiodo, F, Di Perri, G, Galli, M, Iardino, R, Ippolito, G, Lazzarin, A, Mazzotta, F, Panebianco, R, Panebianco, G, Perno, Cf, Ammassari, A, Arici, C, Balotta, C, Bonfanti, P, Capobianchi, Mr, Ceccherini Silberstein, F, De Luca, A, Gervasoni, C, Girardi, E, Lo Caputo, S, Maggiolo, F, Murri, R, Mussini, C, Puoti, M, Torti, Carlo, Montroni, M, Scalise, G, Costantini, A, Riva, A, Tirelli, U, Martellotta, F, Martellotta, G, Ladisa, N, Suter, F, Verucchi, G, Fiorini, C, Cristini, G, Torti, C, Minardi, C, Bertelli, D, Quirino, T, Manconi, Pe, Piano, P, Pizzigallo, E, D'Alessandro, M, Carnevale, G, Lorenzotti, S, Ghinelli, F, Leoncini, F, Pozzi, M, Pagano, G, Viscoli, G, Alessandrini, A, Piscopo, R, Soscia, F, Tacconi, L, Orani, A, Perini, P, Tommasi, D, Congedo, P, Chiodera, A, Moroni, M, Rizzardini, G, Galli, A, Merli, S, Pastecchia, C, Moioli, Mc, Esposito, R, Gori, A, Cagni, S, Abrescia, N, Chirianni, A, Izzo, Cm, De Marco, M, Viglietti, R, Manzillo, E, Ferrari, C, Pizzaferri, P, Filice, G, Bruno, R, Baldelli, F, Camanni, G, Magnani, G, Ursitti, Ma, Arlotti, M, Ortolani, P, Andreoni, M, Antonucci, G, Narciso, P, Tozzi, V, Vullo, V, Zaccarelli, M, Acinapura, R, De Longis, P, Trotta, Mp, Lichtner, M, Carletti, F, Mura, Ms, Madeddu, G, Caramello, P, Orofino, Gc, Sciandra, M, Sciandra, E, Ebo, F, Pellizzer, G, and Buonfrate, D.
Subjects: antiretroviral-naïve patients, discontinuation of HAART
Published: 2010

232. Death rates in HIV-positive antiretroviral-naive patients with CD4 count greater than 350 cells per microL in Europe and North America: a pooled cohort observational study

Author: Study Group on Death Rates at High CD4 Count in Antiretroviral Naive Patients, Lodwick, Rk, Sabin, Ca, Porter, K, Ledergerber, B, van Sighem, A, Cozzi Lepri, A, Khaykin, P, Mocroft, A, Jacobson, L, De Wit, S, Obel, N, Castagna, A, Wasmuth, Jc, Gill, J, Klein, Mb, Gange, S, Riera, M, Mussini, C, Gutiérrez, F, Touloumi, G, Carrieri, P, Guest, Jl, Brockmeyer, Nh, Collaborators: Antoniadou A, Phillips A. N., Gargalianos Kakolyris, P, Katsarou, O, Kordossis, T, Lazanas, M, Panos, G, Paparizos, V, Paraskevis, D, Petrikkos, G, Sambatakou, H, Skoutelis, A, Pantazis, N, Bakoyannis, G, Gioukari, V, de Wolf, F, Bezemer, Do, Gras, La, Kesselring, Am, van Sighem AI, Smit, C, Zhang, S, Zaheri, S, Prins, Jm, Schreij, G, Bravenboer, B, van der Ende ME, Kauffmann, Rh, ten Kate RW, Kroon, Fp, Bronsveld, W, Vriesendorp, R, van Houte, D, ten Napel CH, Brinkman, K, van Eeden, A, Mulder, Jw, Juttmann, Jr, Veenstra, J, Koopmans, Pp, Sprenger, Hg, Hoepelman, Im, Danner, Sa, Richter, C, Tanis, Aa, Clumeck, N, Delforge, M, Necsoi, C, Demeester, R, Gennotte, Af, Gerard, M, Guillaume, Mp, Hermans, P, Kabeya, K, Konopnicki, D, Martin, C, Libois, A, Payen, Mc, Semaille, P, Van Laethem, Y, Del Amo, J, Meyer, L, Bucher, Hc, Chêne, G, Pillay, D, Prins, M, Rosinska, M, Sabin, C, Lodi, S, Coughlin, K, Walker, S, Babiker, A, Bucher, H, de Luca, A, Fisher, M, Muga, R, Fätkenheuer, G, Rockstroh, J, Vehreschild, J, Hertenstein, C, Berenguer, J, del Amo, J, García, F, Labarga, P, Moreno, S, Angeles Muñoz, M, Caro Murillo AM, Sobrino, P, Pérez Cachafeiro, S, Jarrín, I, Alejos, B, García, I, Gómez Sirvent, J, Soriano, V, Pulido, F, Iribarren, J, Masiá, M, Vidal, F, Sanz, J, Blanco, Ja, Sola, J, Gerstoft, J, Kronborg, G, Røge, B, Larsen, Cs, Pedersen, G, Laursen, Al, Nielsen, L, Jensen, J, Babacan, E, Bickel, M, Bodtländer, A, Brodt, Hr, Carlebach, A, Gute, P, Haberl, A, Helm, E, Klauke, S, Knecht, G, Lennemann, T, Locher, L, Lutz, T, Mösch, M, Müller, A, Nisius, G, Staszewski, S, Stephan, C, Stürmer, M, von Hentig, N, Wolf, T, Rimland, D, Moanna, A, Moorfield, M, Dorsey, M, Desilva, Ke, Schlueter Wirtz, S, Mindley, R, Dozier, R, Robinson, Y, Brown, P, Moroni, M, Angarano, G, Antinori, A, Carosi, G, Cauda, R, d'Arminio Monforte, A, Di Perri, G, Galli, M, Ghinelli, G, Iardino, R, Ippolito, G, Lazzarin, A, Mazzotta, F, Perno, Cf, Viale, Pl, Von Schlosser, F, Ammassari, A, Balotta, C, Bonfanti, P, Capobianchi, Mr, Ceccherini Silberstein, F, De Luca, A, Gervasoni, C, Girardi, E, Lo Caputo, S, Maggiolo, F, Murri, R, Puoti, M, Torti, Carlo, Salpietro, S, Marangione, M, Galli, L, Gianotti, N, Cossarini, F, Spagnuolo, V, Arendt, G, Esser, S, Jäger, H, Schwarze, S, Stoll, M, Wolf, H, Jansen, K, Michalik, C, Skaletz Rorowski, A, Königs, C, Gingelmaier, A, Margolick, Jb, Jacobson, Lp, Phair, Jp, Wolinsky, Sm, Detels, R, Rinaldo, Cr, Boirot, C, Bouhnik, Ad, Carrieri, Mp, Cassuto, Jp, Chesney, M, Cohen, J, Dellamonica, P, Dujardin, P, Gallais, H, Gastaut, Ja, Kurkdji, P, Lepeu, G, Mechali, D, Moatti, Jp, Moreau, J, Nègre, M, Obadia, Y, Poizot Martin, I, Pradier, C, Préau, M, Rey, D, Roux, P, Rouzioux, C, Sobel, A, Spire, B, Trémolières, F, Villes, V, Vincent, E, Vlahov, D, Borghi, V, Casabona, J, Miró, Jm, Gatell, Jm, López Dieguez Puerta, M, Tural, C, Clotet, B, Podzamczer, D, Ferrer, E, Murillas, J, Segura, F, Navarro, G, Force, L, Vilaró, J, Masabeu, A, Guadarrama, M, Betancourt, Aj, Romero, A, Agustí, C, Battegay, M, Bernasconi, E, Böni, J, Bürgisser, P, Calmy, A, Cavassini, M, Dubs, R, Egger, M, Elzi, L, Fischer, M, Flepp, M, Fontana, A, Francioli, P, Furrer, H, Fux, Ca, Gorgievski, M, Günthard, Hf, Hirsch, Hh, Hirschel, B, Hösli, I, Kahlert, C, Kaiser, L, Karrer, U, Kind, C, Klimkait, T, Martinetti, G, Martinez, B, Müller, N, Nadal, D, Paccaud, F, Pantaleo, G, Rauch, A, Regenass, S, Rickenbach, M, Rudin, C, Schmid, P, Schultze, D, Schöni, F, Schüpbach, J, Speck, R, Taffé, P, Telenti, A, Trkola, A, Vernazza, P, Weber, R, Yerly, S, Ainsworth, J, Anderson, J, Delpech, V, Dunn, D, Easterbrook, P, Gazzard, B, Gilson, R, Gompels, M, Hill, T, Johnson, M, Leen, C, Nelson, M, Orkin, C, Palfreeman, A, Phillips, A, Post, F, Schwenk, A, Walsh, J, Bansi, L, Huntington, S, Glabay, A, Anastos, K, Minkoff, H, Young, M, Greenblatt, R, Levine, A, Cohen, M, and Gange, S.
Published: 2010

233. Rate of CD4+ cell count increase over periods of viral load suppression: relationship with the number of previous virological failures

Author: Trotta, Mp, Cozzi Lepri, A, Ammassari, A, Vecchiet, J, Cassola, G, Caramello, P, Vullo, V, Soscia, F, Chiodera, A, Ladisa, N, Abeli, C, Cauda, R, Buonuomi, Ar, Antinori, A, d'Arminio Monforte, A, Collaborators: Moroni M, ICONA Foundation S. t. u. d. y., Carosi, Giampiero, Chiodo, F, Di Perri, G, Galli, M, Iardino, R, Ippolito, G, Lazzarin, A, Panebianco, R, Pastore, G, Perno, Cf, Arici, C, Balotta, C, Bonfanti, P, Capobianchi, Mr, Castagna, A, Ceccherini Silberstein, F, De Luca, A, Gervasoni, C, Girardi, E, Lo Caputo, S, Murri, R, Mussini, C, Puoti, M, Torti, Carlo, Montroni, M, Scalise, G, Braschi, Mc, Riva, A, Tirelli, U, Martellotta, F, Suter, F, Colangeli, V, Fiorini, C, Coronado, O, Carosi, G, Cristini, G, Torti, C, Minardi, C, Bertelli, D, Quirino, T, Manconi, Pe, Piano, P, Pizzigallo, E, D'Alessandro, M, Ghinelli, F, Sighinolfi, L, Leoncini, F, Mazzotta, F, Pozzi, M, Grisorio, B, Ferrara, S, Pagano, G, Alessandrini, A, Piscopo, R, Tacconi, L, Orani, A, Perini, P, Chiodera, F, Castelli, P, Moroni, M, Rizzardini, G, Caggese, L, Galli, A, Merli, S, Pastecchia, C, Moioli, Mc, Esposito, R, Abrescia, N, Chirianni, A, De Marco, M, Viglietti, R, Ferrari, C, Pizzaferri, P, Filice, G, Bruno, R, Magnani, G, Ursitti, Ma, Arlotti, M, Ortolani, P, Antonucci, G, Narciso, P, Zaccarelli, M, Acinapura, R, De Longis, P, Lichtner, M, Carletti, F, Mura, Ms, Mannazzu, M, Orofino, Gc, Sciandra, M, Raise, E, Ebo, F, Pellizzer, G, and Buonfrate, D.
Published: 2010

234. High prevalence of the metabolic syndrome in HIV-infected patients: impact of different definitions of the metabolic syndrome

Author: de Wolf, F, Zaheri, S, Gras, L, Bronsveld, W, Hillebrand Haverkort, Me, Prins, Jm, Bos, Jc, Eeftinck Schattenkerk, Jk, Geerlings, Se, Godfried, Mh, Lange, Jm, van Leth, Fc, Lowe, Sh, van der Meer, Jt, Nellen, Fj, Pogány, K, van der Poll, T, Reiss, P, Ruys, Ta, Steingrover, R, van Twillert, G, van der Valk, M, van Vonderen, Mg, Vrouenraets, Sm, van Vugt, M, Wit, Fw, van Eeden, A, ten Veen, Jh, van Dam, Ps, Roos, Jc, Brinkman, K, Frissen, Ph, Weigel, Hm, Mulder, Jw, van Gorp, Ec, Meenhorst, Pl, Mairuhu, At, Veenstra, J, Danner, Sa, Van Agtmael, Ma, Claessen, Fa, Perenboom, Rm, Rijkeboer, A, van Vonderen, M, Richter, C, van der Berg, J, van Leusen, R, Vriesendorp, R, Jeurissen, Fj, Kauffmann, Rh, Koger, El, Bravenboer, B, ten Napel, Ch, Kootstra, Gj, Sprenger, Hg, Miesen, Wm, Doedens, R, Scholvinck, Eh, ten Kate, Rw, van Houte, Dp, Polee, M, Kroon, Fp, van Dissel, Jt, Schippers, Ef, Schreij, G, van de Geest, S, Verbon, A, Koopmans, Pp, Keuter, M, Post, F, van der Ven, Aj, van der Ende, Me, Gyssens, Ic, van der Feltz, M, den Hollander, Jg, de Marie, S, Nouwen, Jl, Rijnders, Bj, de Vries, Te, Juttmann, Jr, van de Heul, C, van Kasteren, Me, Elisabeth, S, Schneider, Mm, Bonten, Mj, Borleffs, Jc, Ellerbroek, Pm, Hoepelman, Im, Jaspers, Ca, Schouten, I, Schurink, Ca, Blok, Wl, Tanis, Aa, Groeneveld, Ph, Salamon, R, Beylot, J, Dupon, M, Le Bras, M, Pellegrin, Jl, Ragnaud, Jm, Dabis, F, Chêne, G, Jacqmin Gadda, H, Thiébaut, R, Lawson Ayayi, S, Lavignolle, V, Balestre, E, Blaizeau, Mj, Decoin, M, Formaggio, Am, Delveaux, S, Labarerre, S, Uwamaliya, B, Vimard, E, Merchadou, L, Palmer, G, Touchard, D, Dutoit, D, Pereira, F, Boulant, B, Morlat, P, Bernard, N, Bonarek, M, Bonnet, F, Coadou, B, Gelie, P, Jaubert, D, Nouts, C, Lacoste, D, Dutronc, H, Cipriano, G, Lafarie, S, Chossat, I, Lacut, Jy, Leng, B, Mercie, P, Viallard, Jf, Faure, I, Rispal, P, Cipriano, C, Tchamgoué, S, Djossou, F, Malvy, D, Pivetaud, Jp, Chambon, D, De La Taille, C, Galperine, T, Neau, D, Ochoa, A, Beylot, C, Doutre, Ms, Bezian, Jh, Moreau, Jf, Taupin, Jl, Conri, C, Constans, J, Couzigou, P, Castera, L, Fleury, H, Lafon, Me, Masquelier, B, Pellegrin, I, Trimoulet, P, Moreau, F, Mestre, C, Series, C, Taytard, A, Law, M, Petoumenos, K, Anderson, J, Cortossis, P, Hoy, J, Watson, K, Roth, N, Nicholson, J, Bloch, M, Franic, T, Baker, D, Mcfarlane, R, Carr, A, Cooper, D, Chuah, J, Fankhauser, W, Mallal, S, Forsdyke, C, Calvo, G, Torres, F, Mateu, S, Domingo, P, Sambeat, Ma, Gatell, J, Del Cacho, E, Cadafalch, J, Fuster, M, Codina, C, Sirera, G, Vaqué, A, Clumeck, N, De Wit, S, Gerard, M, Kabeya, K, Konopnicki, D, Libois, A, Payen, Mc, Poll, B, Van Laethem, Y, Neaton, J, Bartsch, G, El Sadr, Wm, Krum, E, Thompson, G, Wentworth, D, Luskin Hawk, R, Telzak, E, Abrams, Di, Cohn, D, Markowitz, N, Arduino, R, Mushatt, D, Friedland, G, Perez, G, Tedaldi, E, Fisher, E, Gordin, F, Crane, Lr, Sampson, J, Baxter, J, Kirk, O, Mocroft, A, Ellefson, M, Phillips, An, Lundgren, Jd, Losso, M, Elias, C, Vetter, N, Zangerle, R, Karpov, I, Vassilenko, A, Mitsura, Vm, Suetnov, O, Colebunders, R, Vandekerckhove, L, Hadziosmanovic, V, Kostov, K, Begovac, I, Machala, L, Rozsypal, H, Sedlacek, D, Nielsen, J, Kronborg, G, Benfield, T, Larsen, M, Gerstoft, J, Katzenstein, T, Hansen, Ab, Skinhøj, P, Pedersen, C, Oestergaard, L, Zilmer, K, Ristola, M, Katlama, C, Viard, Jp, Girard, Pm, Livrozet, Jm, Vanhems, P, Pradier, C, Rockstroh, J, Schmidt, R, van Lunzen, J, Degen, O, Stellbrink, Hj, Staszewski, S, Bogner, J, Fätkenheuer, G, Gargalianos, P, Xylomenos, G, Perdios, J, Panos, G, Filandras, A, Karabatsaki, E, Sambatakou, H, Banhegyi, D, Mulcahy, F, Yust, I, Turner, D, Burke, M, Pollack, S, Hassoun, G, Maayan, S, Chiesi, A, Esposito, R, Mazeu, I, Mussini, C, Arici, C, Pristera, R, Mazzotta, F, Gabbuti, A, Vullo, V, Lichtner, M, Chirianni, A, Montesarchio, E, Gargiulo, M, Antonucci, G, Iacomi, F, Narciso, P, Vlassi, C, Zaccarelli, M, Lazzarin, A, Finazzi, R, Galli, M, Ridolfo, A, d'Arminio Monforte, A, Rozentale, B, Aldins, P, Chaplinskas, S, Hemmer, R, Staub, T, Bruun, J, Maeland, A, Ormaasen, V, Knysz, B, Gasiorowski, J, Horban, A, Bakowska, E, Prokopowicz, D, Flisiak, R, Boron Kaczmarska, A, Pynka, M, Beniowski, M, Mularska, E, Trocha, H, Jablonowska, E, Malolepsza, E, Wojcik, K, Antunes, F, Valadas, E, Maltez, F, Duiculescu, D, Rakhmanova, A, Vinogradova, E, Buzunova, S, Jevtovic, D, Mokrás, M, Staneková, D, Tomazic, J, González Lahoz, J, Soriano, V, Martin Carbonero, L, Labarga, P, Clotet, B, Jou, A, Paredes, R, Tural, C, Puig, J, Bravo, I, Gatell, Jm, Miró, Jm, Gutierrez, M, Mateo, G, Karlsson, A, Persson, Po, Flamholc, L, Ledergerber, B, Weber, R, Cavassini, M, Hirschel, B, Boffi, E, Furrer, H, Battegay, M, Elzi, L, Kravchenko, E, Chentsova, N, Kutsyna, G, Servitskiy, S, Antoniak, S, Krasnov, M, Barton, S, Johnson, Am, Mercey, D, Phillips, A, Johnson, Ma, Murphy, M, Weber, J, Scullard, G, Fisher, M, Leen, C, Morfeldt, L, Thulin, G, Sundström, A, Akerlund, B, Koppel, K, Håkangård, C, Moroni, M, Carosi, Giampiero, Cauda, R, Chiodo, F, Di Perri, G, Iardino, R, Ippolito, G, Panebianco, R, Pastore, G, Perno, Cf, Ammassari, A, Antinori, A, Balotta, C, Bonfanti, P, Capobianchi, Mr, Castagna, A, Ceccherini Silberstein, F, Cozzi Lepri, A, De Luca, A, Gervasoni, C, Girardi, E, Maggiolo, F, Murri, R, Puoti, M, Torti, C, Fanti, I, Formenti, T, Prosperi, M, Montroni, M, Giacometti, A, Costantini, A, Riva, A, Tirelli, U, Martellotta, F, Ladisa, N, Suter, F, Verucchi, G, Fiorini, C, Carosi, G, Cristini, G, Minardi, C, Bertelli, D, Quirino, T, Abeli, C, Manconi, Pe, Piano, P, Vecchiet, J, Farenga, M, Carnevale, G, Lorenzotti, S, Ghinelli, F, Sighinolfi, L, Leoncini, F, Pozzi, M, Pagano, G, Cassola, G, Viscoli, G, Alessandrini, A, Piscopo, R, Soscia, F, Tacconi, L, Orani, A, Rossotto, R, Tommasi, D, Congedo, P, Chiodera, A, Castelli, P, Rizzardini, G, Schlacht, I, Ridolfo, Al, Foschi, A, Salpietro, S, Merli, S, Melzi, S, Moioli, Mc, Cicconi, P, Gori, A, Abrescia, N, Izzo, Cm, De Marco, M, Viglietti, R, Manzillo, E, Ferrari, C, Pizzaferri, P, Baldelli, F, Camanni, G, Magnani, G, Ursitti, Ma, Arlotti, M, Ortolani, P, Andreoni, M, Tozzi, V, Acinapura, R, De Longis, P, Trotta, Mp, Carletti, F, Mura, Ms, Madeddu, G, Caramello, P, Orofino, Gc, Raise, E, Ebo, F, Pellizzer, G, Buonfrate, D, Fontas, E, Caissotti, C, Dellamonica, P, Bentz, L, Bernard, E, Cua, E, De Salvador Guillouet, F, Durant, J, Farhad, R, Ferrando, S, Mondain Miton, V, Perbost, I, Prouvost Keller, B, Pugliese, P, Rahelinirina, V, Roger, Pm, Vassallo, M, Baëz, E, Bernasconi, E, Böni, J, Bucher, H, Bürgisser, P, Cattacin, S, Dubs, R, Egger, M, Erb, P, Fischer, M, Flepp, M, Fontana, A, Francioli, P, Furrer, Hj, Gorgievski, M, Günthard, H, Kaiser, L, Kind, C, Klimkait, T, Lauper, U, Opravil, M, Paccaud, F, Pantaleo, G, Perrin, L, Piffaretti, Jc, Rickenbach, M, Rudin, C, Schmid, P, Schüpbach, J, Speck, R, Telenti, A, Trkola, A, Vernazza, P, and Yerly, S.
Subjects: HIV, metabolic syndrome
Published: 2010

235. Improved weighted darunavir genotypic mutation score predicting treatment response for HIV-1 subtype B and non-B infected patients receiving darunavir in a salvage regimen

Author: De Luca, A., Flandre, P., Castagna, A., Ceccherini-Silberstein, F., Cozzi-Lepri, A., Churchill, D., De Wit, S., Dunn, D., Fuchs, W., Garcia, F., Guenthard, H., Imaz, A., Kordossis, T., Mussini, C., Obel, N., Roca, B., Santoro, M. M., Schuelter, E., Torti, C., van Sighem, A., Wensing, A. M., Wittkop, L., Zangerle, R., Zazzi, M., Descamps, D., De Luca, A., Flandre, P., Castagna, A., Ceccherini-Silberstein, F., Cozzi-Lepri, A., Churchill, D., De Wit, S., Dunn, D., Fuchs, W., Garcia, F., Guenthard, H., Imaz, A., Kordossis, T., Mussini, C., Obel, N., Roca, B., Santoro, M. M., Schuelter, E., Torti, C., van Sighem, A., Wensing, A. M., Wittkop, L., Zangerle, R., Zazzi, M., and Descamps, D.
Published: 2014

236. KEY GENETIC MARKERS IN THE FULL-LENGTH HBSAG GENE CORRELATE WITH HBV-DRIVEN CARCINOGENESIS BY AFFECTING HBSAG SECRETION AND RELEASE

Author: Svicher, V., Neumann-Fraunea, M., Mirabelli, C., Salpini, R., Cento, V., Di Maio, V. C., Pollicita, M., Bertoli, A., Alteri, C., Aragri, M., Gori, C., Santoro, M. M., Salso, A., Rizzardini, G., Gubertini, G., Micheli, V., Niero, F., Magni, C., Trimoulet, P., Fleury, H., Vecchiet, J., Iapadre, N., Barlattani, A., Mario, T., Pasquazzi, C., Missale, G., Sarrecchia, C., Ceccherini-Silberstein, F., Andreoni, M., Angelico, M., Verhejen, J., Perno, C. F., Svicher, V., Neumann-Fraunea, M., Mirabelli, C., Salpini, R., Cento, V., Di Maio, V. C., Pollicita, M., Bertoli, A., Alteri, C., Aragri, M., Gori, C., Santoro, M. M., Salso, A., Rizzardini, G., Gubertini, G., Micheli, V., Niero, F., Magni, C., Trimoulet, P., Fleury, H., Vecchiet, J., Iapadre, N., Barlattani, A., Mario, T., Pasquazzi, C., Missale, G., Sarrecchia, C., Ceccherini-Silberstein, F., Andreoni, M., Angelico, M., Verhejen, J., and Perno, C. F.
Published: 2014

237. Longitudinal analysis of HIV-1 coreceptor tropism by single and triplicate HIV-1 RNA and DNA sequencing in patients undergoing successful first-line antiretroviral therapy

Author: Meini, G, Rossetti, B, Bianco, C, Ceccherini Silberstein, F, Di Giambenedetto, S, Sighinolfi, L, Monno, L, Castagna, A, Rozera, G, D'arminio Monforte, A, Zazzi, M, De Luca, A, Moroni, M, Armignacco, O, Iardino, R, Ippolito, G, Perno, C, Von Schloesser, F, Cozzi Lepri, A, Girardi, E, Balotta, C, Borderi, M, Capobianchi, M, Cinque, P, Di Biagio, A, Gianotti, N, Guaraldi, G, Lichtner, M, Marcotullio, S, Rusconi, S, Formenti, T, Galli, L, Lorenzini, P, Giacometti, A, Costantini, A, Angarano, G, Santoro, C, Maggiolo, F, Suardi, C, Viale, P, Vanino, E, Verucchi, G, Castelli, F, Quiros Roldan, E, Minardi, C, Quirino, T, Abeli, C, Manconi, P, Piano, P, Vecchiet, J, Falasca, K, Segala, D, Mazzotta, F, Lo Caputo, S, Cassola, G, Viscoli, G, Alessandrini, A, Piscopo, R, Mazzarello, G, Mastroianni, C, Belvisi, V, Bonfanti, P, Caramma, I, Castelli, A, Galli, M, Lazzarin, A, Rizzardini, G, Puoti, M, Ridolfo, A, Piolini, R, Salpietro, S, Carenzi, L, Moioli, M, Cicconi, P, Marchetti, G, Mussini, C, Puzzolante, C, Gori, A, Lapadula, G, Abrescia, N, Chirianni, A, Guida, M, Gargiulo, M, Baldelli, F, Francisci, D, Parruti, G, Ursini, T, Magnani, G, Ursitti, M, Cauda, R, Andreoni, M, Antinori, A, Vullo, V, Cingolani, A, D'Avino, A, Ammassari, A, Gallo, L, Nicastri, E, Acinapura, R, Capozzi, M, Libertone, R, Tebano, G, Cattelan, A, Mura, M, Madeddu, G, Caramello, P, Di Perri, G, Orofino, G, Bonora, S, Sciandra, M, Pellizzer, G, Manfrin, V, Manfrin, V., GORI, ANDREA, Meini, G, Rossetti, B, Bianco, C, Ceccherini Silberstein, F, Di Giambenedetto, S, Sighinolfi, L, Monno, L, Castagna, A, Rozera, G, D'arminio Monforte, A, Zazzi, M, De Luca, A, Moroni, M, Armignacco, O, Iardino, R, Ippolito, G, Perno, C, Von Schloesser, F, Cozzi Lepri, A, Girardi, E, Balotta, C, Borderi, M, Capobianchi, M, Cinque, P, Di Biagio, A, Gianotti, N, Guaraldi, G, Lichtner, M, Marcotullio, S, Rusconi, S, Formenti, T, Galli, L, Lorenzini, P, Giacometti, A, Costantini, A, Angarano, G, Santoro, C, Maggiolo, F, Suardi, C, Viale, P, Vanino, E, Verucchi, G, Castelli, F, Quiros Roldan, E, Minardi, C, Quirino, T, Abeli, C, Manconi, P, Piano, P, Vecchiet, J, Falasca, K, Segala, D, Mazzotta, F, Lo Caputo, S, Cassola, G, Viscoli, G, Alessandrini, A, Piscopo, R, Mazzarello, G, Mastroianni, C, Belvisi, V, Bonfanti, P, Caramma, I, Castelli, A, Galli, M, Lazzarin, A, Rizzardini, G, Puoti, M, Ridolfo, A, Piolini, R, Salpietro, S, Carenzi, L, Moioli, M, Cicconi, P, Marchetti, G, Mussini, C, Puzzolante, C, Gori, A, Lapadula, G, Abrescia, N, Chirianni, A, Guida, M, Gargiulo, M, Baldelli, F, Francisci, D, Parruti, G, Ursini, T, Magnani, G, Ursitti, M, Cauda, R, Andreoni, M, Antinori, A, Vullo, V, Cingolani, A, D'Avino, A, Ammassari, A, Gallo, L, Nicastri, E, Acinapura, R, Capozzi, M, Libertone, R, Tebano, G, Cattelan, A, Mura, M, Madeddu, G, Caramello, P, Di Perri, G, Orofino, G, Bonora, S, Sciandra, M, Pellizzer, G, Manfrin, V, Manfrin, V., and GORI, ANDREA
Abstract: Objectives: Maraviroc has been shown to be effective in patients harbouring CCR5-tropic HIV-1. While this CCR5 antagonist has initially been used in salvage therapy, its excellent safety profile makes it ideal for antiretroviral treatment simplification strategies in patients with suppressed plasma viraemia. The aim of this study was to compare HIV-1 tropism as detected in baseline plasma RNA and peripheral blood mononuclear cell (PBMC) DNA prior to first-line therapy and to analyse tropism evolution while on successful treatment. Methods: HIV-1 tropism was determined using triplicate genotypic testing combined with geno2pheno[coreceptor] analysis at a 10% false positive rate in 42 patients. Paired pre-treatment plasma RNA and PBMC DNA and two subsequent PBMC DNA samples (the first obtained after reaching undetectable plasma HIV-1 RNA and the second after at least 2 years of suppression of plasma viraemia) were evaluated. Results: Coreceptor tropism was completely concordant in paired pre-treatment RNA and DNA, with 26.2% of HIV-1 sequences predicted to be non-CCR5-tropic. During follow-up, coreceptor tropism switches were detected in 4 (9.5%) patients without any preferential direction. Although false positive rate discrepancies within triplicates were common, the rate of discordance of coreceptor tropism assignment among triplicate results in this mostly CCR5-tropic dataset was only 2.1%, questioning the added value of triplicate testing compared with single testing. Conclusions: HIV-1 coreceptor tropism changes during virologically successful first-line treatment are infrequent. HIV-1 DNA analysis may thus support the choice of a CCR5 antagonist in treatment switch strategies; however, maraviroc treatment outcome data are required to confirm this option. © The Author 2013. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved
Published: 2014

238. Durability of lopinavir/ritonavir dual-therapies in individuals with viral load <50 copies/mL in the observational setting

Author: Gianotti, N, Cozzi Lepri, A, Antinori, A, Di Biagio, A, Moioli, Mc, Nozza, S, Cingolani, Antonella, De Luca, Andrea, Madeddu, G, Bonora, S, Ceccherini Silberstein, F, Monforte, Ad, Cingolani, Antonella (ORCID:0000-0002-3793-2755), De Luca, Andrea (ORCID:0000-0002-8311-6935), Gianotti, N, Cozzi Lepri, A, Antinori, A, Di Biagio, A, Moioli, Mc, Nozza, S, Cingolani, Antonella, De Luca, Andrea, Madeddu, G, Bonora, S, Ceccherini Silberstein, F, Monforte, Ad, Cingolani, Antonella (ORCID:0000-0002-3793-2755), and De Luca, Andrea (ORCID:0000-0002-8311-6935)
Abstract: We aimed at evaluating the efficacy and durability of a lopinavir/ritonavir-based dual regimen (LPV/r-DR) in virologically controlled HIV-infected individuals in current clinical practice.
Published: 2014

239. Evolution of HIV-1 tropism at quasispecies level after 5 years of combination antiretroviral therapy in patients always suppressed or experiencing episodes of virological failure

Author: Rozera, G, Abbate, I, Giombini, E, Castagna, A, De Luca, A, Ceccherini-Silberstein, F, Cozzi Lepri, A, Cassola, G, Torti, C, d'Arminio Monforte, A, Ippolito, G, Capobianchi, M, Gori, A, Lapadula, G, Rozera, G, Abbate, I, Giombini, E, Castagna, A, De Luca, A, Ceccherini-Silberstein, F, Cozzi Lepri, A, Cassola, G, Torti, C, d'Arminio Monforte, A, Ippolito, G, Capobianchi, M, Gori, A, and Lapadula, G
Abstract: OBJECTIVES: Tropism evolution of HIV-1 quasispecies was analysed by ultra-deep pyrosequencing (UDPS) in patients on first-line combination antiretroviral therapy (cART) always suppressed or experiencing virological failure episodes.METHODS: Among ICONA patients, two groups of 20 patients on cART for ≥5 years, matched for baseline viraemia and therapy duration, were analysed [Group I, patients always suppressed; and Group II, patients experiencing episode(s) of virological failure]. Viral tropism was assessed by V3 UDPS on plasma RNA before therapy (T0) and on peripheral blood mononuclear cell proviral DNA before-after therapy (T0-T1), using geno2pheno false positive rate (FPR) (threshold for X4: 5.75). For each sample, quasispecies tropism was assigned according to X4 variant frequency: R5, <0.3% X4; minority X4, 0.3%-19.9% X4; and X4, ≥20% X4. An R5-X4 switch was defined as a change from R5/minority X4 in plasma/proviral genomes at T0 to X4 in provirus at T1.RESULTS: At baseline, mean FPR and %X4 of viral RNA were positively correlated with those of proviral DNA. After therapy, proviral DNA load significantly decreased in Group I; mean FPR of proviral quasispecies significantly decreased and %X4 increased in Group II. An R5-X4 switch was observed in five patients (two in Group I and three in Group II), all harbouring minority X4 variants at T0.CONCLUSIONS: UDPS analysis reveals that the tropism switch is not an 'on-off' phenomenon, but may result from a profound re-shaping of viral quasispecies, even under suppressive cART. However, episodes of virological failure seem to prevent reduction of proviral DNA and to accelerate viral evolution, as suggested by decreased FPR and increased %X4 at T1 in Group II patients
Published: 2014

240. Trends and correlates of HIV-1 resistance among subjects failing an antiretroviral treatment over the 2003-2012 decade in Italy

Author: Franzetti, M, Violin, M, Antinori, A, De Luca, Andrea, Ceccherini Silberstein, F, Gianotti, N, Torti, C, Bonora, S, Zazzi, M, Balotta, C., De Luca, Andrea (ORCID:0000-0002-8311-6935), Franzetti, M, Violin, M, Antinori, A, De Luca, Andrea, Ceccherini Silberstein, F, Gianotti, N, Torti, C, Bonora, S, Zazzi, M, Balotta, C., and De Luca, Andrea (ORCID:0000-0002-8311-6935)
Abstract: Despite a substantial reduction in virological failures following introduction of new potent antiretroviral therapies in the latest years, drug resistance remains a limitation for the control of HIV-1 infection. We evaluated trends and correlates of resistance in treatment failing patients in a comprehensive database over a time period of relevant changes in prescription attitudes and treatment guidelines.
Published: 2014

241. Immune activation and microbial translocation in liver disease progression in HIV/hepatitis co-infected patients: results from the Icona Foundation study

Author: Marchetti, G, Cozzi Lepri, A, Tincati, C, Calcagno, A, Ceccherini Silberstein, F, De Luca, Andrea, Antinori, A, Castagna, A, Puoti, M, Monforte, Ad, De Luca, Andrea (ORCID:0000-0002-8311-6935), Marchetti, G, Cozzi Lepri, A, Tincati, C, Calcagno, A, Ceccherini Silberstein, F, De Luca, Andrea, Antinori, A, Castagna, A, Puoti, M, Monforte, Ad, and De Luca, Andrea (ORCID:0000-0002-8311-6935)
Abstract: We evaluated whether immune activation (IA) and microbial translocation (MT) might play a role in accelerating liver disease progression in HIV-HBV/HCV co-infected patients.
Published: 2014

242. Genotypic testing on HIV-1 DNA as a tool to assess HIV-1 co-receptor usage in clinical practice: results from the DIVA study group

Author: Svicher, V, Alteri, C, Montano, M, Nori, A, D'Arrigo, R, Andreoni, M, Angarano, G, Antinori, A, Antonelli, G, Allice, T, Bagnarelli, P, Baldanti, F, Bertoli, A, Borderi, M, Boeri, E, Bon, I, Bruzzone, B, Barresi, R, Calderisi, S, Callegaro, Ap, Capobianchi, Mr, Gargiulo, F, Castelli, F, Cauda, Roberto, Ceccherini Silberstein, F, Clementi, M, Chirianni, A, Colafigli, Manuela, D'Arminio Monforte, A, De Luca, Andrea, Di Biagio, A, Di Nicuolo, G, Di Perri, G, Di Santo, F, Fadda, G, Galli, M, Gennari, W, Ghisetti, V, Costantini, A, Gori, A, Gulminetti, R, Leoncini, F, Maffongelli, G, Maggiolo, F, Maserati, R, Mazzotta, F, Meini, G, Micheli, V, Monno, L, Mussini, C, Nozza, S, Paolucci, S, Palù, G, Parisi, S, Parruti, G, Pignataro, Ar, Quirino, T, Re, Mc, Rizzardini, G, Sanguinetti, Maurizio, Santangelo, Rosaria, Scaggiante, R, Sterrantino, G, Turriziani, O, Vatteroni, Ml, Viscoli, C, Vullo, V, Zazzi, M, Lazzarin, A, Perno, Cf, Cauda, Roberto (ORCID:0000-0002-1498-4229), De Luca, Andrea (ORCID:0000-0002-8311-6935), Sanguinetti, Maurizio (ORCID:0000-0002-9780-7059), Santangelo, Rosaria (ORCID:0000-0002-8056-218X), Svicher, V, Alteri, C, Montano, M, Nori, A, D'Arrigo, R, Andreoni, M, Angarano, G, Antinori, A, Antonelli, G, Allice, T, Bagnarelli, P, Baldanti, F, Bertoli, A, Borderi, M, Boeri, E, Bon, I, Bruzzone, B, Barresi, R, Calderisi, S, Callegaro, Ap, Capobianchi, Mr, Gargiulo, F, Castelli, F, Cauda, Roberto, Ceccherini Silberstein, F, Clementi, M, Chirianni, A, Colafigli, Manuela, D'Arminio Monforte, A, De Luca, Andrea, Di Biagio, A, Di Nicuolo, G, Di Perri, G, Di Santo, F, Fadda, G, Galli, M, Gennari, W, Ghisetti, V, Costantini, A, Gori, A, Gulminetti, R, Leoncini, F, Maffongelli, G, Maggiolo, F, Maserati, R, Mazzotta, F, Meini, G, Micheli, V, Monno, L, Mussini, C, Nozza, S, Paolucci, S, Palù, G, Parisi, S, Parruti, G, Pignataro, Ar, Quirino, T, Re, Mc, Rizzardini, G, Sanguinetti, Maurizio, Santangelo, Rosaria, Scaggiante, R, Sterrantino, G, Turriziani, O, Vatteroni, Ml, Viscoli, C, Vullo, V, Zazzi, M, Lazzarin, A, Perno, Cf, Cauda, Roberto (ORCID:0000-0002-1498-4229), De Luca, Andrea (ORCID:0000-0002-8311-6935), Sanguinetti, Maurizio (ORCID:0000-0002-9780-7059), and Santangelo, Rosaria (ORCID:0000-0002-8056-218X)
Abstract: We have developed a sequencing assay for determining the usage of the genotypic HIV-1 co-receptor using peripheral blood mononuclear cell (PBMC) DNA in virologically suppressed HIV-1 infected patients. Our specific aims were to (1) evaluate the efficiency of V3 sequences in B versus non-B subtypes, (2) compare the efficiency of V3 sequences and tropism prediction using whole blood and PBMCs for DNA extraction, (3) compare the efficiency of V3 sequences and tropism prediction using a single versus a triplicate round of amplification.
Published: 2014

243. Characterization of the patterns of drug-resistance mutations in newly diagnosed HIV-1 infected patients naïve to the antiretroviral drugs

Author: Alteri, C, Svicher, V, Gori, C, D'Arrigo, R, Ciccozzi, M, CECCHERINI SILBERSTEIN, F, Selleri, M, Bardacci, S, Giuliani, M, Elia, P, Scognamiglio, P, Balzano, R, Orchi, N, Girardi, E, Perno, Cf, Capobianchi, M, De Carli, G, Galati, V, Grisetti, S, Navarra, A, Nicastri, E, Pittalis, S, Puro, V, Sampaolesi, A, Nurra, G, Zaccarelli, M, Zaniratti, M, Di Carlo, A, De Filippis, A, Brancatella, R, Maggi, T, Gattari, P, Spizzichino, L, Schito, S, Sarmati, L, Battagin, G, Tacconi, L, Gallo, I, Anzalone, E, Pitorri, A, Caterini, A, and Barbacci, S
Subjects: virus strain, Male, genotype, Drug Resistance, Human immunodeficiency virus 1, Etravirine, RNA directed DNA polymerase inhibitor, HIV Infections, Drug resistance, RNA directed DNA polymerase, HIV Antibodies, Cohort Studies, Medical microbiology, binding affinity, Prevalence, HIV Protease Inhibitor, genetics, Viral, Phylogeny, virus mutation, drug effect, article, virus diseases, homosexuality, Middle Aged, cohort analysis, Infectious Diseases, Italy, virus resistance, Cohort, RNA, Viral, Reverse Transcriptase Inhibitors, proteinase, Female, Research Article, medicine.drug, Cohort study, Adult, medicine.medical_specialty, Settore MED/17 - Malattie Infettive, Evolution, proteinase inhibitor, Human immunodeficiency virus antibody, virus RNA, adult, antiviral resistance, codon, DNA polymorphism, female, human, Human immunodeficiency virus 1 infection, major clinical study, male, phylogeny, prevalence, virus carrier, virus load, blood, Human immunodeficiency virus infection, middle aged, molecular evolution, mutation, sequence alignment, statistical model, Drug Resistance, Viral, Evolution, Molecular, HIV Protease Inhibitors, HIV-1, Humans, Logistic Models, Mutation, Sequence Alignment, Biology, lcsh:Infectious and parasitic diseases, medicine, lcsh:RC109-216, Molecular, Virology, Reverse transcriptase, Drug-naïve, Immunology, RNA
Abstract: BackgroundThe transmission of HIV-1 drug-resistant strains in drug naive patients may seriously compromise the efficacy of a first-line antiretroviral treatment. To better define this problem, a study in a cohort of newly diagnosed HIV-1 infected individuals has been conducted. This study is aimed to assess the prevalence and the patterns of the mutations recently associated with transmitted drug resistance in the reverse transcriptase (RT) and in protease (PR) of HIV-1.MethodsPrevalence of transmitted drug resistant strains is determined in 255 newly diagnosed HIV-1 infected patients enrolled in different counselling and testing (CT) centres in Central Italy; the Avidity Index (AI) on the first available serum sample is also used to estimate time since infection. Logistic regression models are used to determine factors associated with infection by drug resistant HIV-1 strains.ResultsThe prevalence of HIV-1 strains with at least one major drug resistance mutation is 5.9% (15/255); moreover, 3.9% (10/255) of patients is infected with HIV nucleoside reverse transcriptase inhibitor (NRTI)-resistant viruses, 3.5% (9/255) with HIV non-NRTI-resistant viruses and 0.4% (1/255) with HIV protease inhibitor (PI)-resistant viruses. Most importantly, almost half (60.0%) of patients carries HIV-1 resistant strains with more than one major drug resistance mutation. In addition, patients who had acquired HIV through homosexual intercourses are more likely to harbour a virus with at least one primary resistance mutation (OR 7.7; 95% CI: 1.7–35.0, P = 0.008).ConclusionThe prevalence of drug resistant HIV-1 strains among newly diagnosed individuals in Central Italy is consistent with the data from other European countries. Nevertheless, the presence of drug-resistance HIV-1 mutations in complex patterns highlights an additional potential risk for public health and strongly supports the extension of wide genotyping to newly diagnosed HIV-1 infected patients.
Published: 2009
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244. Risk of developing specific AIDS-defining illnesses in patients coinfected with HIV and hepatitis C virus with or without liver cirrhosis

Author: d'Arminio Monforte, A, Cozzi Lepri, A, Castagna, A, Antinori, A, De Luca, A, Mussini, C, Caputo, Sl, Arlotti, M, Magnani, G, Pellizzer, G, Maggiolo, F, Puoti, M, Collaborators: Moroni M, Icona Foundation Study G. r. o. u. p., Carosi, Giampiero, Cauda, R, Cauda, F, Di Perri, G, Galli, M, Iardino, R, Ippolito, G, Lazzarin, A, Mazzotta, F, Panebianco, R, Pastore, G, Perno, Cf, Ammassari, A, Balotta, C, Bonfanti, P, Capobianchi, Mr, Ceccherini Silberstein, F, Cozzi Lepri, C, Gervasoni, C, Girardi, E, Lo Caputo, S, Murri, R, Torti, Carlo, Fanti, I, Formenti, T, Prosperi, M, Montroni, M, Giacometti, A, Costantini, A, Riva, A, Tirelli, U, Martellotta, F, Ladisa, N, Suter, F, Chiodo, F, Verucchi, G, Fiorini, C, Carosi, G, Cristini, C, Minardi, C, Bertelli, D, Quirino, T, Abeli, C, Manconi, Pe, Piano, P, Pizzigallo, E, Dalessandro, M, Carnevale, G, Lorenzotti, S, Ghinelli, F, Sighinolfi, L, Leoncini, F, Pozzi, M, Pagano, G, Cassola, G, Viscoli, G, Alessandrini, A, Piscopo, R, Soscia, F, Tacconi, L, Orani, A, Rossotto, R, Tommasi, D, Congedo, P, Chiodera, A, Castelli, P, Rizzardini, G, Schlacht, I, Ridolfo, Al, Foschi, A, Salpietro, S, Merli, S, Melzi, S, Moioli, Mc, Cicconi, P, Esposito, R, Gori, A, Borrello, A, Abrescia, N, Chirianni, A, Izzo, Cm, De Marco, M, Viglietti, R, Manzillo, E, Ferrari, C, Pizzaferri, P, Baldelli, F, Camanni, G, Ursitti, Ma, Ortolani, P, Andreoni, M, Antonucci, G, Narciso, P, Tozzi, V, Vullo, V, Zaccarelli, M, Acinapura, R, De Longis, P, Trotta, Mp, Lichtner, M, Carletti, F, Mura, Ms, Madeddu, G, Caramello, P, Orofino, G, Raise, E, Ebo, F, and Buonfrate, D.
Published: 2009

245. The Treatment with the Fusion Inhibitor Enfuvirtide Influences the Appearance of Mutations in the HIV-1 Regulatory Protein Rev

Author: Svicher, V., Alteri, C., Darrigo, R., Laganà, A., Trignetti, M., LO CAPUTO, S., Callegaro, A. P., Maggiolo, F., Mazzotta, F., Ferro, Alfredo, Dimonte, S., Aquaro, S., DI PERRI, G., Bonora, S., Tommasi, C., Trotta, M. P., Narciso, P., Antinori, A., Perno, C. F., and CECCHERINI SILBERSTEIN, F.
Published: 2009

246. Viral interference between hepatitis B, C, and D viruses in dual and triple infections in HIV-positive patients

Author: Ancarani, F, Antinori, A, Antonucci, G, Bruno, R, Capobianchi, M, Cingolani, A, Cozzi Lepri, A, d'Arminio Monforte, A, Galli, M, Girardi, E, Marino, N, Morsica, G, Narciso, P, Pastecchia, C, Pizzaferri, P, Puoti, M, Santantonio, T, Verucchi, G, Ammassari, A, Arici, C, Balotta, C, Bonfanti, P, Capobianchi, Mr, Castagna, A, Ceccherini Silberstein, F, De Luca, A, Gervasoni, C, Lo Caputo, S, Murri, R, Mussini, C, Torti, C, Moroni, M, Carosi, Giampiero, Cauda, R, Chiodo, F, Di Perri, G, Iardino, R, Ippolito, G, Lazzarin, A, Mazzotta, F, Panebianco, R, Pastore, G, Perno, Cf, Montroni, M, Scalise, G, Costantini, A, Riva, A, Tirelli, U, Martellotta, F, Ladisa, N, Suter, F, Maggiolo, F, Colangeli, V, Fiorini, C, Carosi, G, Cristini, G, Minardi, C, Bertelli, D, Quirino, T, Manconi, P, Piano, P, Pizzigallo, E, Dalessandro, M, Carnevale, G, Zoncada, A, Ghinelli, F, Sighinolfi, L, Leoncini, F, Pozzi, M, Grisorio, B, Ferrara, S, Pagano, G, Cassola, G, Alessandrini, A, Piscopo, R, Soscia, F, Tacconi, L, Orani, A, Perini, P, Tommasi, D, Congedo, P, Chiodera, F, Castelli, P, Rizzardini, G, Caggese, L, Galli, A, Merli, S, Moioli, M, Esposito, R, Gori, A, Cagni, S, Abrescia, N, Chirianni, A, Izzo, Cm, De Marco, M, Viglietti, R, Manzillo, E, Ferrari, C, Filice, G, Magnani, G, Ursitti, M, Arlotti, M, Ortolani, P, Andreoni, M, Tozzi, V, Vullo, V, Zaccarelli, M, Acinapura, R, De Longis, P, Trotta, M, Lichtner, M, Carletti, F, Mura, M, Mannazzu, M, Caramello, P, Orofino, G, Sciandra, M, Raise, E, Ebo, F, Pellizzer, G, and Buonfrate, D.
Subjects: HDV, HCV, HBV, HIV
Published: 2009

247. Mortality from HIV and TB coinfections is higher in Eastern Europe than in Western Europe and Argentina

Author: Podlekareva, Dn, Mocroft, A, Post, Fa, Riekstina, V, Miro, Jm, Furrer, H, Bruyand, M, Panteleev, Am, Rakhmanova, Ag, Girardi, E, Losso, Mh, Toibaro, Jj, Caylá, J, Miller, Rf, Obel, N, Skrahina, A, Chentsova, N, Lundgren, Jd, Kirk, O, Collaborators: Losso MH, HIV/TB Study Writing G. r. o. u. p., Warley, E, Tamayo, N, Cristina Ortiz, M, Santojanni, F, Scapelatto, P, Bottaro, E, Murano, F, Miachans, M, Contarelli, J, Massera, L, Corral, J, Hualde, M, Miglioranza, C, Corti, M, Metta, H, Casiró, A, Cuini, R, Laplume, H, David, D, Marson, C, Lupo, S, Trape, L, Garcia Messina, O, Gear, O, Ramos Mejía JM, Bruguera, Jm, Karpov, I, Vasilenko, A, Skrahina, E, Skrahin, A, Zhavoronok, S, Mitsura, V, Ruzanov, D, Bondarenko, V, Suetnov, O, Paduto, D, Gerstoft, J, Kronborg, G, Pedersen, C, Larsen, Cs, Pedersen, G, Laursen, Al, Nielsen, L, Jensen, J, Dabis, F, Chêne, G, Lawson Ayayi, S, Thiébaut, R, Winnock, M, Bernard, N, Dupon, M, Lacoste, D, Malvy, D, Mercié, P, Morlat, P, Neau, D, Pellegrin, Jl, Ragnaud, Jm, Moreau, Jf, Blanco, P, Fleury, H, Lafon, Me, Masquelier, B, Pellegrin, I, Blaizeau, Mj, Decoin, M, Delveaux, S, Dutoit, D, Geffard, S, Hannapier, C, Houinou, L, Labarrère, S, Lavignolle Aurillac, V, Palmer, G, Touchard, D, Bonarek, M, Bonnet, F, Lacombe, K, Gellie, P, Paccalin, F, Pertusa, Mc, Dutronc, H, Dauchy, F, Lafarie, S, Longy Boursier, M, Pistonne, T, Receveur, Mc, Thibaut, P, Cazorla, C, Chambon, D, De La Taille, C, Galpérine, T, Ochoa, A, Viallard, Jf, Caubet, O, Nouts, C, Couzigou, P, Castera, L, Loste, P, Caunègre, L, Bonnal, F, Farbos, S, Gemain, Mc, Ceccaldi, J, Tchamgoue, S, Witte, Sd, Carvalho, Ac, Basché, R, Hamad, Ie, Ricci, Ba, Maggiolo, F, Ravasio, V, Mussini, C, Prati, F, Castelletti, S, Spallanzani, L, Antinori, A, Antonucci, G, Bibbolino, C, Bove, G, Busi Rizzi, E, Cicalini, S, Conte, A, Cuzzi, G, De Mori, P, Festa, A, Goletti, D, Grisetti, S, Gualano, G, Lauria, Fn, Maddaluno, R, Migliorisi Ramazzini, P, Narciso, P, Parracino, L, Palmieri, F, Petrosillo, N, Pucillo, L, Puro, V, Vanacore, P, Urso, R, Moroni, M, Carosi, Giampiero, Cauda, R, Chiodo, F, d'Arminio Monforte, A, Di Perri, G, Galli, M, Iardino, R, Ippolito, G, Lazzarin, A, Mazzotta, F, Panebianco, R, Pastore, G, Perno, Cf, Ammassari, A, Arici, C, Balotta, C, Bonfanti, P, Capobianchi, Mr, Castagna, A, Ceccherini Silberstein, F, Cozzi Lepri, A, De Luca, A, Gervasoni, C, Lo Caputo, S, Murri, R, Puoti, Massimo, Torti, Carlo, Fanti, I, Formenti, T, Prosperi, M, Montroni, M, Giacoemtti, A, Costantini, A, Riva, A, Tirelli, U, Martellotta, F, Ladisa, N, Suter, F, Verucchi, G, Fiorini, C, Carosi, G, Cristini, G, Torti, C, Minardi, C, Bertelli, D, Quirino, T, Abeli, C, Manconi, Pe, Piano, P, Pizzigallo, E, Dalessandro, M, Carnevale, G, Lorenzotti, S, Ghinelli, F, Sighinolfi, L, Leoncini, F, Pozzi, M, Pagano, G, Cassola, G, Viscoli, G, Alessandrini, A, Piscopo, R, Soscia, F, Tacconi, L, Orani, A, Rossotto, R, Tommasi, D, Congedo, P, Chiodera, A, Castelli, P, Rizzardini, G, Schlacht, I, Ridolfo, Al, Foschi, A, Salpietro, S, Merli, S, Melzi, S, Moioli, Mc, Cicconi, P, Esposito, R, Gori, A, Borrello, A, Abrescia, N, Chirianni, A, Izzo, Cm, De Marco, M, Viglietti, R, Manzillo, E, Ferrari, C, Pizzaferri, P, Baldelli, F, Camanni, G, Magnani, G, Ursitti, Ma, Arlotti, M, Ortolani, P, Andreoni, M, Tozzi, V, Vullo, V, Zaccarelli, M, Acinapura, R, De Longis, P, Trotta, Mp, Lichtner, M, Carletti, F, Mura, Ms, Madeddu, G, Caramello, P, Orofino, Gc, Raise, E, Ebo, F, Pellizzer, G, Buonfrate, D, Aldins, P, Duiculescu, D, Rakhmanova, A, Malashenkov, E, Kozlov, A, Panteleev, A, Buzunova, S, García Goez JF, Moreno Camacho, A, Martínez, Ja, González, J, García Alcaide, F, de Lazzari, E, Gatell, Jm, Sanchez, P, Lopez Colomes JL, Martínez Lacasa, X, Falcó, V, Imaz, A, Ocaña, I, Vidal, R, Sambeat, Ma, Caylà, J, Moreno Martínez, A, Orcau, A, Weber, R, Battegay, M, Hirschel, B, Cavassini, M, Bernasconi, E, Schmid, P, Rickenbach, M, Post, F, Campbell, L, Miller, R, Arenas Pinto, A, Podlekareva, D, Kjaer, J, Ellefson, M, and Toibaro, J. J.
Subjects: HIV/TB coinfection, Eastern Europe, Western Europe, Argentina
Published: 2009

248. Characterization of drug-resistance mutations in HIV type 1 isolates from drug-naive and ARV-treated patients in Bulgaria

Author: Santoro, M, Ciccozzi, M, Alteri, C, Montieri, S, Alexiev, I, Dimova, I, CECCHERINI SILBERSTEIN, F, Beshkov, D, Rezza, G, and Perno, Cf
Subjects: Male, Molecular Sequence Data, HIV Protease Inhibitors, Plasma, Humans, Sequence Analysis, DNA, RNA, Viral, Mutation, Missense, HIV-1, Reverse Transcriptase Inhibitors, Drug Resistance, Viral, Anti-Retroviral Agents, HIV Infections, HIV Reverse Transcriptase, Bulgaria, HIV Protease, Amino Acid Substitution, Female, Drug Resistance, DNA, Settore MED/07 - Microbiologia e Microbiologia Clinica, Mutation, RNA, Viral, Missense, Sequence Analysis
Published: 2008

249. HIV-induced immunodeficiency and mortality from AIDS-defining and non-AIDS-defining malignancies

Author: Monforte, A, Abrams, D, Pradier, C, Weber, R, Reiss, P, Bonnet, F, Kirk, O, Law, M, De Wit, S, Friis Møller, N, Phillips, An, Sabin, Ca, Lundgren, Jd, Collaborators: Collins S, Data Collection on Adverse Events of Anti HIV Drugs Study G. r. o. u. p., Loeliger, E, Tressler, R, Weller, I, Worm, Sw, Sjøl, A, Sawitz, A, Rickenbach, M, Pezzotti, P, Krum, E, Gras, L, Balestre, E, Sundström, A, Poll, B, Fontas, E, Torres, F, Petoumenos, K, Kjaer, J, de Wolf, F, Zaheri, S, Bronsveld, W, Hillebrand Haverkort ME, Prins, Jm, Bos, Jc, Schattenkerk, Jk, Geerlings, Se, Godfried, Mh, Lange, Jm, van Leth FC, Lowe, Sh, van der Meer JT, Nellen, Fj, Pogány, K, van der Poll, T, Ruys, Ta, Sankatsing, Sr, van Twillert, G, van der Valk, M, van Vonderen MG, Vrouenraets, Sm, van Vugt, M, Wit, Fw, van Eeden, A, ten Veen JH, van Dam PS, Roos, Jc, Brinkman, K, Frissen, Ph, Weigel, Hm, Mulder, Jw, van Gorp EC, Meenhorst, Pl, Mairuhu, At, Veenstra, J, Danner, Sa, Van Agtmael MA, Claessen, Fa, Perenboom, Rm, Rijkeboer, A, van Vonderen, M, Richter, C, van der Berg, J, van Leusen, R, Vriesendorp, R, Jeurissen, Fj, Kauffmann, Rh, Koger, El, Bravenboer, B, ten Napel CH, Kootstra, Gj, Sprenger, Hg, Miesen, Wm, Doedens, R, Scholvinck, Eh, ten Kate RW, van Houte DP, Polee, M, Kroon, Fp, van den Broek, van Dissel JT, Schippers, Ef, Schreij, G, van de Geest, S, Verbon, A, Koopmans, Pp, Keuter, M, Post, F, van der Ven AJ, van der Ende ME, Gyssens, Ic, van der Feltz, M, den Hollander JG, de Marie, S, Nouwen, Jl, Rijnders, Bj, de Vries TE, Juttmann, Jr, van de Heul, C, van Kasteren ME, St Elisabeth SM, Bonten, Mj, Borleffs, Jc, Ellerbroek, Pm, Hoepelman, Im, Jaspers, Ca, Schouten, I, Schurink, Ca, Blok, Wl, Tanis, Aa, Groeneveld, Ph, Salamon, R, Beylot, J, Dupon, M, Le Bras, M, Pellegrin, Jl, Ragnaud, Jm, Dabis, F, Chêne, G, Jacqmin Gadda, H, Thiébaut, R, Lawson Ayayi, S, Lavignolle, V, Blaizeau, Mj, Decoin, M, Formaggio, Am, Delveaux, S, Labarerre, S, Uwamaliya, B, Vimard, E, Merchadou, L, Palmer, G, Touchard, D, Dutoit, D, Pereira, F, Boulant, B, Morlat, P, Bernard, N, Bonarek, M, Coadou, B, Gelie, P, Jaubert, D, Nouts, C, Lacoste, D, Dutronc, H, Cipriano, G, Lafarie, S, Chossat, I, Lacut, Jy, Leng, B, Mercié, P, Viallard, Jf, Faure, I, Rispal, P, Cipriano, C, Tchamgoué, S, Djossou, F, Malvy, D, Pivetaud, Jp, Chambon, D, De La Taille, C, Galperine, T, Neau, D, Ochoa, A, Beylot, C, Doutre, Ms, Bezian, Jh, Moreau, Jf, Taupin, Jl, Conri, C, Constans, J, Couzigou, P, Castera, L, Fleury, H, Lafon, Me, Masquelier, B, Pellegrin, I, Trimoulet, P, Moreau, F, Mestre, C, Series, C, Taytard, A, Glenday, K, Anderson, J, Cortissos, P, Mijch, A, Watson, K, Roth, N, Nicolson, J, Bloch, M, Agrawal, S, Franic, T, Baker, D, Vale, R, Carr, A, Cooper, D, Lacey, M, Hesse, K, Chuah, J, Lester, D, Fankhauser, W, Mallal, S, Forsdyke, C, Bulgannawar, S, Calvo, G, Mateu, S, Domingo, P, Sambeat, Ma, Gatell, J, Del Cacho, E, Cadafalch, J, Fuster, M, Codina, C, Sirera, G, Vaqué, A, Clumeck, N, Gerard, M, Kabeya, K, Konopnicki, D, Libois, A, Payen, Mc, Van Laethem, Y, Neaton, J, Bartsch, G, El Sadr WM, Thompson, G, Wentworth, D, Luskin Hawk, R, Telzak, E, Abrams, Di, Cohn, D, Markowitz, N, Arduino, R, Mushatt, D, Friedland, G, Perez, G, Tedaldi, E, Fisher, E, Gordin, F, Crane, Rl, Sampson, J, Baxter, J, Olsen, Ch, Mocroft, A, Vetter, N, Karpov, I, Vassilenko, A, Colebunders, R, Machala, L, Rozsypal, H, Sedlacek, D, Nielsen, J, Benfield, T, Gerstoft, J, Katzenstein, T, Hansen, Ab, Skinhøj, P, Pedersen, C, Zilmer, K, Katlama, C, Viard, Jp, Girard, Pm, Saint Marc, T, Vanhems, P, Dietrich, M, Manegold, C, van Lunzen, J, Stellbrink, Hj, Staszewski, S, Bieckel, M, Goebel, Fd, Fätkenheuer, C, Rockstroh, J, Schmidt, Re, Kosmidis, J, Gargalianos, P, Sambatakou, H, Perdios, J, Panos, G, Filandras, A, Banhegyi, D, Mulcahy, F, Yust, I, Burke, M, Turner, D, Pollack, S, Hassoun, J, Sthoeger, Z, Maayan, S, Vella, S, Chiesi, A, Arici, C, Pristerá, R, Mazzotta, F, Gabbuti, A, Esposito, R, Bedini, A, 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Manzillo, E, Ferrari, C, Pizzaferri, P, Filice, G, Bruno, R, Magnani, G, Ursitti, Ma, Arlotti, M, Ortolani, P, Andreoni, M, Antonucci, G, Tozzi, V, Acinapura, R, De Longis, P, Trotta, Mp, Lichtner, M, Carletti, F, Mura, Mc, Mannazzu, M, Caramello, P, Orofino, Gc, Sciandra, M, Raise, E, Ebo, F, Pellizzer, G, Buonfrate, D, Caissotti, C, Dellamonica, P, Bentz, L, Bernard, E, De Salvador Guillouet, F, Durant, J, Mondain Miton, V, Perbost, I, Prouvost Keller, B, Pugliese, P, Rahelinirina, V, Roger, Pm, Vandenbos, F, Battegay, M, Bernasconi, E, Böni, J, Bucher, H, Bürgisser, P, Cattacin, S, Cavassini, M, Dubs, R, Egger, M, Elzi, L, Erb, P, Fischer, M, Flepp, M, Fontana, A, Furrer, Hj, Gorgievski, M, Günthard, H, Kaiser, L, Kind, C, Klimkait, T, Lauper, U, Opravil, M, Paccaud, F, Pantaleo, G, Perrin, L, Piffaretti, Jc, Schmid, Cr, Schüpbach, J, Speck, R, Trkola, A, Vernazza, P, and Yerly, S.
Published: 2008

250. Synonymous Mutations are Involved in the Highly Ordered Regulation of NRTI Resistance

Author: Svicher, V, Alteri, C, Laganà, A, Pigola, G, Dimonte, S, Mussini, C, Forbici, F, Ferro, Alfredo, Narciso, P, Antinori, A, CECCHERINI SILBERSTEIN, F, and Perno, C. F.
Published: 2008

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