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4,049 results on '"Carroll, Thomas"'

201. Deletion of Lats1/2 in adult kidney epithelia leads to renal cell carcinoma

Author

Carter, Phoebe, Schnell, Ulrike, Chaney, Christopher, Tong, Betty, Pan, Xinchao, Ye, Jianhua, Mernaugh, Glenda, Cotton, Jennifer L., Margulis, Vitaly, Mao, Junhao, Zent, Roy, Evers, Bret M., Kapur, Payal, and Carroll, Thomas J.

Subjects
Epithelium -- Genetic aspects -- Health aspects, Tumor suppressor genes -- Health aspects, Kidneys -- Genetic aspects -- Health aspects, Carcinoma, Renal cell -- Risk factors -- Genetic aspects, Health care industry
Abstract

Renal cell carcinoma (RCC) is the most common kidney cancer in humans. Misregulation of the Hippo/Warts pathway is frequently reported in RCC, suggesting a role in disease formation/progression. Paradoxically, misregulation of this pathway is also observed in non-tumorigenic kidney diseases, raising questions as to its specific role in RCC. Here, we show that ablation of the Warts kinases Lats1 and Lats2 in mature renal epithelia was sufficient to cause metastatic RCC in mice. Distinct tumors with sarcomatoid histology were present in mutant kidneys 3 months after genetic ablation. Tumor formation required the downstream effectors Yap and Taz, and treatment with verteporfin, a drug that inhibits Yap activity, could slow progression of the disease. Examination of human tissues showed that among histological subtypes of RCC, nuclear YAP was most commonly observed in sarcomatoid RCC. However, analysis of transcriptomic data from human RCC revealed a unique subset with a molecular signature that closely resembled the transcriptome of Lats mutants. Together, these findings show that misregulation of the Warts pathway is sufficient to drive renal tumor formation in mice and suggest that human tumors with active YAP may represent a unique subset of RCCs that can be therapeutically targeted., Introduction The Hippo/Warts (Mst/Lats) pathway is one of the major signaling pathways regulating organ size and tissue growth during embryonic development (1). The pathway controls the activity of several genes [...]

Published
2021
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204. Reactive oxygen species regulate axonal regeneration through the release of exosomal NADPH oxidase 2 complexes into injured axons

Author

Hervera, Arnau, De Virgiliis, Francesco, Palmisano, Ilaria, Zhou, Luming, Tantardini, Elena, Kong, Guiping, Hutson, Thomas, Danzi, Matt C., Perry, Rotem Ben-Tov, Santos, Celio X. C., Kapustin, Alexander N., Fleck, Roland A., Del Río, José Antonio, Carroll, Thomas, Lemmon, Vance, Bixby, John L., Shah, Ajay M., Fainzilber, Mike, and Di Giovanni, Simone

Published
2018
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205. Genetically engineering endothelial niche in human kidney organoids enables multilineage maturation, vascularization, and de novo cell types

Author

Maggiore, Joseph C, primary, LeGraw, Ryan, additional, Przepiorski, Aneta, additional, Velazquez, Jeremy, additional, Chaney, Christopher, additional, Streeter, Evan, additional, Silva-Barbosa, Anne, additional, Franks, Jonathan, additional, Hislop, Joshua, additional, Hill, Alex, additional, Wu, Haojia, additional, Pfister, Katherine, additional, Howden, Sara E, additional, Watkins, Simon C, additional, Little, Melissa, additional, Humphreys, Benjamin, additional, Watson, Alan, additional, Stolz, Donna B, additional, Kiani, Samira, additional, Davidson, Alan J, additional, Carroll, Thomas J., additional, Cleaver, Ondine J., additional, Sims-Lucas, Sunder, additional, Ebrahimkhani, Mo R, additional, and Hukriede, Neil A, additional

Published
2023
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208. Functional characterization of C21ORF2 association with the NEK1 kinase mutated in human in diseases

Author

Gregorczyk, Mateusz, primary, Pastore, Graziana, additional, Muñoz, Ivan, additional, Carroll, Thomas, additional, Streubel, Johanna, additional, Munro, Meagan, additional, Lis, Pawel, additional, Lange, Sven, additional, Lamoliatte, Frederic, additional, Macartney, Thomas, additional, Toth, Rachel, additional, Brown, Fiona, additional, Hastie, James, additional, Pereira, Gislene, additional, Durocher, Daniel, additional, and Rouse, John, additional

Published
2023
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214. Abstract LB131: Association between epigenetic heterogeneity of esophageal adenocarcinoma and response to first-line immunochemotherapy in LUD2015-005 Trial

Author

Xie, Phil F., primary, Chang, Jaeho, additional, Siejka-Zielińska, Paulina, additional, Inoue, Masato, additional, Drożdż, Magdalena, additional, Chadwick, Joseph A., additional, Carroll, Thomas M., additional, Owen, Richard P., additional, White, Michael J., additional, Kaplinsky, Joseph, additional, Amess, Robert, additional, Middleton, Mark, additional, Kriaucionis, Skirmantas, additional, Song, Chunxiao, additional, Schuster-Böckler, Benjamin, additional, and Lu, Xin, additional

Published
2023
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215. Supplementary Table 3 from A Molecular Switch between Mammalian MLL Complexes Dictates Response to Menin–MLL Inhibition

Author

Soto-Feliciano, Yadira M., primary, Sánchez-Rivera, Francisco J., primary, Perner, Florian, primary, Barrows, Douglas W., primary, Kastenhuber, Edward R., primary, Ho, Yu-Jui, primary, Carroll, Thomas, primary, Xiong, Yijun, primary, Anand, Disha, primary, Soshnev, Alexey A., primary, Gates, Leah, primary, Beytagh, Mary Clare, primary, Cheon, David, primary, Gu, Shengqing, primary, Liu, X. Shirley, primary, Krivtsov, Andrei V., primary, Meneses, Maximiliano, primary, de Stanchina, Elisa, primary, Stone, Richard M., primary, Armstrong, Scott A., primary, Lowe, Scott W., primary, and Allis, C. David, primary

Published
2023
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216. Data from A Molecular Switch between Mammalian MLL Complexes Dictates Response to Menin–MLL Inhibition

Author

Soto-Feliciano, Yadira M., primary, Sánchez-Rivera, Francisco J., primary, Perner, Florian, primary, Barrows, Douglas W., primary, Kastenhuber, Edward R., primary, Ho, Yu-Jui, primary, Carroll, Thomas, primary, Xiong, Yijun, primary, Anand, Disha, primary, Soshnev, Alexey A., primary, Gates, Leah, primary, Beytagh, Mary Clare, primary, Cheon, David, primary, Gu, Shengqing, primary, Liu, X. Shirley, primary, Krivtsov, Andrei V., primary, Meneses, Maximiliano, primary, de Stanchina, Elisa, primary, Stone, Richard M., primary, Armstrong, Scott A., primary, Lowe, Scott W., primary, and Allis, C. David, primary

Published
2023
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217. Supplementary Table 2 from A Molecular Switch between Mammalian MLL Complexes Dictates Response to Menin–MLL Inhibition

Author

Soto-Feliciano, Yadira M., primary, Sánchez-Rivera, Francisco J., primary, Perner, Florian, primary, Barrows, Douglas W., primary, Kastenhuber, Edward R., primary, Ho, Yu-Jui, primary, Carroll, Thomas, primary, Xiong, Yijun, primary, Anand, Disha, primary, Soshnev, Alexey A., primary, Gates, Leah, primary, Beytagh, Mary Clare, primary, Cheon, David, primary, Gu, Shengqing, primary, Liu, X. Shirley, primary, Krivtsov, Andrei V., primary, Meneses, Maximiliano, primary, de Stanchina, Elisa, primary, Stone, Richard M., primary, Armstrong, Scott A., primary, Lowe, Scott W., primary, and Allis, C. David, primary

Published
2023
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218. Supplementary Table 4 from A Molecular Switch between Mammalian MLL Complexes Dictates Response to Menin–MLL Inhibition

Author

Soto-Feliciano, Yadira M., primary, Sánchez-Rivera, Francisco J., primary, Perner, Florian, primary, Barrows, Douglas W., primary, Kastenhuber, Edward R., primary, Ho, Yu-Jui, primary, Carroll, Thomas, primary, Xiong, Yijun, primary, Anand, Disha, primary, Soshnev, Alexey A., primary, Gates, Leah, primary, Beytagh, Mary Clare, primary, Cheon, David, primary, Gu, Shengqing, primary, Liu, X. Shirley, primary, Krivtsov, Andrei V., primary, Meneses, Maximiliano, primary, de Stanchina, Elisa, primary, Stone, Richard M., primary, Armstrong, Scott A., primary, Lowe, Scott W., primary, and Allis, C. David, primary

Published
2023
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219. Supplementary Table 1 from A Molecular Switch between Mammalian MLL Complexes Dictates Response to Menin–MLL Inhibition

Author

Soto-Feliciano, Yadira M., primary, Sánchez-Rivera, Francisco J., primary, Perner, Florian, primary, Barrows, Douglas W., primary, Kastenhuber, Edward R., primary, Ho, Yu-Jui, primary, Carroll, Thomas, primary, Xiong, Yijun, primary, Anand, Disha, primary, Soshnev, Alexey A., primary, Gates, Leah, primary, Beytagh, Mary Clare, primary, Cheon, David, primary, Gu, Shengqing, primary, Liu, X. Shirley, primary, Krivtsov, Andrei V., primary, Meneses, Maximiliano, primary, de Stanchina, Elisa, primary, Stone, Richard M., primary, Armstrong, Scott A., primary, Lowe, Scott W., primary, and Allis, C. David, primary

Published
2023
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220. Supplementary Figures from A Molecular Switch between Mammalian MLL Complexes Dictates Response to Menin–MLL Inhibition

Author

Soto-Feliciano, Yadira M., primary, Sánchez-Rivera, Francisco J., primary, Perner, Florian, primary, Barrows, Douglas W., primary, Kastenhuber, Edward R., primary, Ho, Yu-Jui, primary, Carroll, Thomas, primary, Xiong, Yijun, primary, Anand, Disha, primary, Soshnev, Alexey A., primary, Gates, Leah, primary, Beytagh, Mary Clare, primary, Cheon, David, primary, Gu, Shengqing, primary, Liu, X. Shirley, primary, Krivtsov, Andrei V., primary, Meneses, Maximiliano, primary, de Stanchina, Elisa, primary, Stone, Richard M., primary, Armstrong, Scott A., primary, Lowe, Scott W., primary, and Allis, C. David, primary

Published
2023
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222. Supplementary Figure 1 from Salt-Inducible Kinase 2 Regulates Mitotic Progression and Transcription in Prostate Cancer

Author

Bon, Hélène, primary, Wadhwa, Karan, primary, Schreiner, Alexander, primary, Osborne, Michelle, primary, Carroll, Thomas, primary, Ramos-Montoya, Antonio, primary, Ross-Adams, Helen, primary, Visser, Matthieu, primary, Hoffmann, Ralf, primary, Ahmed, Ahmed Ashour, primary, Neal, David E., primary, and Mills, Ian G., primary

Published
2023
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223. Supplementary Table S1 from Salt-Inducible Kinase 2 Regulates Mitotic Progression and Transcription in Prostate Cancer

Author

Bon, Hélène, primary, Wadhwa, Karan, primary, Schreiner, Alexander, primary, Osborne, Michelle, primary, Carroll, Thomas, primary, Ramos-Montoya, Antonio, primary, Ross-Adams, Helen, primary, Visser, Matthieu, primary, Hoffmann, Ralf, primary, Ahmed, Ahmed Ashour, primary, Neal, David E., primary, and Mills, Ian G., primary

Published
2023
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224. Data from Spatiotemporal Loss of NF1 in Schwann Cell Lineage Leads to Different Types of Cutaneous Neurofibroma Susceptible to Modification by the Hippo Pathway

Author

Chen, Zhiguo, primary, Mo, Juan, primary, Brosseau, Jean-Philippe, primary, Shipman, Tracey, primary, Wang, Yong, primary, Liao, Chung-Ping, primary, Cooper, Jonathan M., primary, Allaway, Robert J., primary, Gosline, Sara J.C., primary, Guinney, Justin, primary, Carroll, Thomas J., primary, and Le, Lu Q., primary

Published
2023
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225. Supplementary Figure 8 from Salt-Inducible Kinase 2 Regulates Mitotic Progression and Transcription in Prostate Cancer

Author

Bon, Hélène, primary, Wadhwa, Karan, primary, Schreiner, Alexander, primary, Osborne, Michelle, primary, Carroll, Thomas, primary, Ramos-Montoya, Antonio, primary, Ross-Adams, Helen, primary, Visser, Matthieu, primary, Hoffmann, Ralf, primary, Ahmed, Ahmed Ashour, primary, Neal, David E., primary, and Mills, Ian G., primary

Published
2023
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226. Supplementary Figure Legend from Salt-Inducible Kinase 2 Regulates Mitotic Progression and Transcription in Prostate Cancer

Author

Bon, Hélène, primary, Wadhwa, Karan, primary, Schreiner, Alexander, primary, Osborne, Michelle, primary, Carroll, Thomas, primary, Ramos-Montoya, Antonio, primary, Ross-Adams, Helen, primary, Visser, Matthieu, primary, Hoffmann, Ralf, primary, Ahmed, Ahmed Ashour, primary, Neal, David E., primary, and Mills, Ian G., primary

Published
2023
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227. Supplementary Figure 3 from Salt-Inducible Kinase 2 Regulates Mitotic Progression and Transcription in Prostate Cancer

Author

Bon, Hélène, primary, Wadhwa, Karan, primary, Schreiner, Alexander, primary, Osborne, Michelle, primary, Carroll, Thomas, primary, Ramos-Montoya, Antonio, primary, Ross-Adams, Helen, primary, Visser, Matthieu, primary, Hoffmann, Ralf, primary, Ahmed, Ahmed Ashour, primary, Neal, David E., primary, and Mills, Ian G., primary

Published
2023
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228. Supplemental Figures and Table from Spatiotemporal Loss of NF1 in Schwann Cell Lineage Leads to Different Types of Cutaneous Neurofibroma Susceptible to Modification by the Hippo Pathway

Author

Chen, Zhiguo, primary, Mo, Juan, primary, Brosseau, Jean-Philippe, primary, Shipman, Tracey, primary, Wang, Yong, primary, Liao, Chung-Ping, primary, Cooper, Jonathan M., primary, Allaway, Robert J., primary, Gosline, Sara J.C., primary, Guinney, Justin, primary, Carroll, Thomas J., primary, and Le, Lu Q., primary

Published
2023
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229. Supplementary Figure 5 from Salt-Inducible Kinase 2 Regulates Mitotic Progression and Transcription in Prostate Cancer

Author

Bon, Hélène, primary, Wadhwa, Karan, primary, Schreiner, Alexander, primary, Osborne, Michelle, primary, Carroll, Thomas, primary, Ramos-Montoya, Antonio, primary, Ross-Adams, Helen, primary, Visser, Matthieu, primary, Hoffmann, Ralf, primary, Ahmed, Ahmed Ashour, primary, Neal, David E., primary, and Mills, Ian G., primary

Published
2023
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230. Supplementary Figure 4 from Salt-Inducible Kinase 2 Regulates Mitotic Progression and Transcription in Prostate Cancer

Author

Bon, Hélène, primary, Wadhwa, Karan, primary, Schreiner, Alexander, primary, Osborne, Michelle, primary, Carroll, Thomas, primary, Ramos-Montoya, Antonio, primary, Ross-Adams, Helen, primary, Visser, Matthieu, primary, Hoffmann, Ralf, primary, Ahmed, Ahmed Ashour, primary, Neal, David E., primary, and Mills, Ian G., primary

Published
2023
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231. Supplementary Figure 6 from Salt-Inducible Kinase 2 Regulates Mitotic Progression and Transcription in Prostate Cancer

Author

Bon, Hélène, primary, Wadhwa, Karan, primary, Schreiner, Alexander, primary, Osborne, Michelle, primary, Carroll, Thomas, primary, Ramos-Montoya, Antonio, primary, Ross-Adams, Helen, primary, Visser, Matthieu, primary, Hoffmann, Ralf, primary, Ahmed, Ahmed Ashour, primary, Neal, David E., primary, and Mills, Ian G., primary

Published
2023
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232. Supplementary Figure 7 from Salt-Inducible Kinase 2 Regulates Mitotic Progression and Transcription in Prostate Cancer

Author

Bon, Hélène, primary, Wadhwa, Karan, primary, Schreiner, Alexander, primary, Osborne, Michelle, primary, Carroll, Thomas, primary, Ramos-Montoya, Antonio, primary, Ross-Adams, Helen, primary, Visser, Matthieu, primary, Hoffmann, Ralf, primary, Ahmed, Ahmed Ashour, primary, Neal, David E., primary, and Mills, Ian G., primary

Published
2023
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233. Supplementary Figure 2 from Salt-Inducible Kinase 2 Regulates Mitotic Progression and Transcription in Prostate Cancer

Author

Bon, Hélène, primary, Wadhwa, Karan, primary, Schreiner, Alexander, primary, Osborne, Michelle, primary, Carroll, Thomas, primary, Ramos-Montoya, Antonio, primary, Ross-Adams, Helen, primary, Visser, Matthieu, primary, Hoffmann, Ralf, primary, Ahmed, Ahmed Ashour, primary, Neal, David E., primary, and Mills, Ian G., primary

Published
2023
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234. Chemo-phosphoproteomic profiling with ATR inhibitors berzosertib and gartisertib uncovers new biomarkers and DNA damage response regulators

Author

Jadav, Rathan Singh, primary, Weiland, Florian, additional, Noordermeer, Sylvie M, additional, Carroll, Thomas, additional, Gao, Yuandi, additional, Wang, Jianming, additional, Zhou, Houjiang, additional, Lamoliatte, Frederic, additional, Munoz, Ivan, additional, Toth, Rachel, additional, Macartney, Thomas, additional, Brown, Fiona, additional, Hastie, Christopher J, additional, Alabert, Constance, additional, van Attikum, Haico, additional, Zenke, Frank, additional, Masson, Jean-Yves, additional, and Rouse, John, additional

Published
2023
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235. Reservoir computing with noise

Author

Nathe, Chad, primary, Pappu, Chandra, additional, Mecholsky, Nicholas A., additional, Hart, Joe, additional, Carroll, Thomas, additional, and Sorrentino, Francesco, additional

Published
2023
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237. 128 A single-arm pilot study of an adapted Serious Illness Care Program for older patients with acute myeloid leukemia and myelodysplastic syndromes

Author

LoCastro, Marissa, primary, Mendler, Jason, additional, Norton, Sally, additional, Bernacki, Rachelle, additional, Carroll, Thomas, additional, Klepin, Heidi, additional, Mortaz-Hedjri, Soroush, additional, Jensen-Battaglia, Marielle, additional, Liesveld, Jane, additional, Huselton, Eric, additional, O’Dwyer, Kristen, additional, Baran, Andrea, additional, Flannery, Marie, additional, Kluger, Benzi, additional, and Loh, Kah Poh, additional

Published
2023
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241. ATR phosphoproteomics - DHX9 validation

Author

Jadav, Rathan S, Weiland, Florian, Carroll, Thomas, Gao, Yuandi, Wang, Jianming, Zhou, Houjiang, Lamoliatte, Frederic, Muñoz, Ivan, Toth, Rachel, Macartney, Thomas, van Attikum, Haico, Brown, Fiona, Hastie, James, Alabert, Constance, Zenke, Frank, Noordermeer, Sylvie, Masson, Jean-Yves, and Rouse, John

Abstract

Data analysis scripts for the validation of DHX9 as ATR substrate

Published
2023
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242. ATR: SCAF1 immunoprecipitation

Author

Jadav, Rathan S, Weiland, Florian, Carroll, Thomas, Gao, Yuandi, Wang, Jianming, Zhou, Houjiang, Lamoliatte, Frederic, Muñoz, Ivan, Toth, Rachel, Macartney, Thomas, van Attikum, Haico, Brown, Fiona, Hastie, James, Alabert, Constance, Zenke, Frank, Noordermeer, Sylvie, Masson, Jean-Yves, and Rouse, John

Abstract

R scripts for the analysis of endogenous SCAF1 immunoprecipitation data.

Published
2023
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244. Hosea, Amos, Micah

Author

M. Daniel Carroll, Thomas E. McComiskey, Tremper Longman III, David E. Garland

Published
2017

245. Using Phase Space Methods for Target Identification

Author

Carroll, Thomas L., Rachford, Frederic J., Abarbanel, Henry, Series editor, Braha, Dan, Series editor, Érdi, Péter, Series editor, Friston, Karl, Series editor, Haken, Hermann, Series editor, Jirsa, Viktor, Series editor, Kacprzyk, Janusz, Series editor, Kaneko, Kunihiko, Series editor, Kelso, Scott, Series editor, Kirkilionis, Markus, Series editor, Kurths, Jürgen, Series editor, Nowak, Andrzej, Series editor, Reichl, Linda, Series editor, Schuster, Peter, Series editor, Schweitzer, Frank, Series editor, Sornette, Didier, Series editor, Thurner, Stefan, Series editor, In, Visarath, editor, Palacios, Antonio, editor, and Longhini, Patrick, editor

Published
2014
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246. VCP/p97-associated proteins are binders and debranching enzymes of K48–K63-branched ubiquitin chains

Author

Lange, Sven M., McFarland, Matthew R., Lamoliatte, Frederic, Carroll, Thomas, Krshnan, Logesvaran, Pérez-Ràfols, Anna, Kwasna, Dominika, Shen, Linnan, Wallace, Iona, Cole, Isobel, Armstrong, Lee A., Knebel, Axel, Johnson, Clare, De Cesare, Virginia, and Kulathu, Yogesh

Abstract

Branched ubiquitin (Ub) chains constitute a sizable fraction of Ub polymers in human cells. Despite their abundance, our understanding of branched Ub function in cell signaling has been stunted by the absence of accessible methods and tools. Here we identify cellular branched-chain-specific binding proteins and devise approaches to probe K48–K63-branched Ub function. We establish a method to monitor cleavage of linkages within complex Ub chains and unveil ATXN3 and MINDY as debranching enzymes. We engineer a K48–K63 branch-specific nanobody and reveal the molecular basis of its specificity in crystal structures of nanobody-branched Ub chain complexes. Using this nanobody, we detect increased K48–K63-Ub branching following valosin-containing protein (VCP)/p97 inhibition and after DNA damage. Together with our discovery that multiple VCP/p97-associated proteins bind to or debranch K48–K63-linked Ub, these results suggest a function for K48–K63-branched chains in VCP/p97-related processes.

Published
2024
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248. STATegra, a comprehensive multi-omics dataset of B-cell differentiation in mouse

Author

Gomez-Cabrero, David, Tarazona, Sonia, Ferreirós-Vidal, Isabel, Ramirez, Ricardo N., Company, Carlos, Schmidt, Andreas, Reijmers, Theo, Paul, Veronica von Saint, Marabita, Francesco, Rodríguez-Ubreva, Javier, Garcia-Gomez, Antonio, Carroll, Thomas, Cooper, Lee, Liang, Ziwei, Dharmalingam, Gopuraja, van der Kloet, Frans, Harms, Amy C., Balzano-Nogueira, Leandro, Lagani, Vincenzo, Tsamardinos, Ioannis, Lappe, Michael, Maier, Dieter, Westerhuis, Johan A., Hankemeier, Thomas, Imhof, Axel, Ballestar, Esteban, Mortazavi, Ali, Merkenschlager, Matthias, Tegner, Jesper, and Conesa, Ana

Published
2019
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249. Diagnosis of vocal cord dysfunction/inducible laryngeal obstruction: An International Delphi Consensus Study.

Author

Leong, Paul, Vertigan, Anne E., Hew, Mark, Baxter, Malcolm, Phyland, Debra, Hull, James H., Carroll, Thomas L., Gibson, Peter G., McDonald, Vanessa M., Halvorsen, Thomas, Clemm, Hege Havstad, Vollsæter, Maria, Røksund, Ola Drange, and Bardin, Philip G.

Abstract

Vocal cord dysfunction/inducible laryngeal obstruction (VCD/ILO) is characterized by breathing difficulties in association with excessive supraglottic or glottic laryngeal narrowing. The condition is common and can occur independently; however, it may also be comorbid with other disorders or mimic them. Presentations span multiple specialties and misdiagnosis or delayed diagnosis is commonplace. Group-consensus methods can efficiently generate internationally accepted diagnostic criteria and descriptions to increase clinical recognition, enhance clinical service availability, and catalyze research. We sought to establish consensus-based diagnostic criteria and methods for VCD/ILO. We performed a modified 2-round Delphi study between December 7, 2021, and March 14, 2022. The study was registered at ANZCTR (Australian New Zealand Clinical Trials Registry; ACTRN12621001520820p). In round 1, experts provided open-ended statements that were categorized, deduplicated, and amended for clarity. These were presented to experts for agreement ranking in round 2, with consensus defined as ≥70% agreement. Both rounds were completed by 47 international experts. In round 1, 1102 qualitative responses were received. Of the 200 statements presented to experts across 2 rounds, 130 (65%) reached consensus. Results were discussed at 2 international subject-specific conferences in June 2022. Experts agreed on a diagnostic definition for VCD/ILO and endorsed the concept of VCD/ILO phenotypes and clinical descriptions. The panel agreed that laryngoscopy with provocation is the gold standard for diagnosis and that ≥50% laryngeal closure on inspiration or Maat grade ≥2 define abnormal laryngeal closure indicative of VCD/ILO. This Delphi study reached consensus on multiple aspects of VCD/ILO diagnosis and can inform clinical practice and facilitate research. [ABSTRACT FROM AUTHOR]

Published
2023
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