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992 results on '"Carreras, Enric"'

202. Feasibility and Outcome of Allogeneic Hematopoietic Stem-Cell Transplantation in High-Risk AML: Real-Life Perspective from a Single Institution

Author

Diaz-Beya, Marina, primary, Torrente, Miguel Angel, additional, Ardilla, Alfonso, additional, Serra, Carles, additional, Martinez, Nuria, additional, Suarez-Lledo, Maria, additional, Martinez, Carmen, additional, Fernandez, Francesc, additional, Rosiñol, Laura, additional, Gutierrez, Gonzalo, additional, Marin, Pedro, additional, Pratcorona, Marta, additional, Mariegues, Nuria, additional, Llobet, Noemi, additional, Bistagne, Marta, additional, Carreras, Enric, additional, Urbano-Ispizua, Alvaro, additional, Rovira, Montserrat, additional, and Esteve, Jordi, additional

Published
2015
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203. Improving safety of autologous haematopoietic stem cell transplantation in patients with Crohn's disease

Author

Jauregui-Amezaga, Aranzazu, primary, Rovira, Montserrat, additional, Marín, Pedro, additional, Salas, Azucena, additional, Pinó-Donnay, Susana, additional, Feu, Faust, additional, Elizalde, J Ignasi, additional, Fernández-Avilés, Francesc, additional, Martínez, Carmen, additional, Gutiérrez, Gonzalo, additional, Rosiñol, Laura, additional, Carreras, Enric, additional, Urbano, Alvaro, additional, Lozano, Miguel, additional, Cid, Joan, additional, Suárez-Lledó, María, additional, Mensa, Josep, additional, Rimola, Jordi, additional, Rodríguez, Sonia, additional, Masamunt, Mari Carme, additional, Comas, Dolors, additional, Ruíz, Irene, additional, Ramírez-Morros, Anna, additional, Gallego, Marta, additional, Ordás, Ingrid, additional, Panés, Julian, additional, and Ricart, Elena, additional

Published
2015
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207. Biomarkers for Diagnosis and Prognosis of Sinusoidal Obstruction Syndrome after Hematopoietic Stem Cell Transplantation

Author

Mumaw, Christen L, primary, Akil, Ayman, additional, Velez de Mendizabal, Nieves, additional, Zhang, Qing, additional, Raiker, Nisha, additional, Yu, Jeffrey, additional, Diaz-Ricart, Maribel, additional, Carreras, Enric, additional, Haneline, Laura S., additional, Robertson, Kent A., additional, Elmore, Lindsey, additional, Case, Rose, additional, Renbarger, Jamie, additional, Hanash, Samir, additional, Bies, Robert R., additional, and Paczesny, Sophie, additional

Published
2014
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212. Common variants in NLRP2 and NLRP3 genes are strong prognostic factors for the outcome of HLA-identical sibling allogeneic stem cell transplantation

Author

Universitat Politècnica de Catalunya. Departament de Llenguatges i Sistemes Informàtics, Universitat Politècnica de Catalunya. ALBCOM - Algorismia, Bioinformàtica, Complexitat i Mètodes Formals, Gaya, Anna, Granell, Miquel, Urbano-Ispiuza, Álvaro, Pons, Aina, Aróstigui, Juan Ignacio, Gel Moreno, Bernat, Navarro, Alfons, Jansana, Sonia, Artells, Rosa, Monzó, Mariano, Montserrat, Emili, Yagüe, Jordi, Juan, Manel, Rozman, Ciril, Carreras, Enric, Rovira, Montserrat, Martínez, Carmen, Fernández-Avilés, Francesc, Talarn, Carme, Universitat Politècnica de Catalunya. Departament de Llenguatges i Sistemes Informàtics, Universitat Politècnica de Catalunya. ALBCOM - Algorismia, Bioinformàtica, Complexitat i Mètodes Formals, Gaya, Anna, Granell, Miquel, Urbano-Ispiuza, Álvaro, Pons, Aina, Aróstigui, Juan Ignacio, Gel Moreno, Bernat, Navarro, Alfons, Jansana, Sonia, Artells, Rosa, Monzó, Mariano, Montserrat, Emili, Yagüe, Jordi, Juan, Manel, Rozman, Ciril, Carreras, Enric, Rovira, Montserrat, Martínez, Carmen, Fernández-Avilés, Francesc, and Talarn, Carme

Abstract

The inflammasomes are macromolecular cytosolic complexes involved in the production of interleukin-1beta (IL-1beta) and IL-18 in response to several pathogen-derived stimuli. Such interleukins have been implicated in the origin of severe allogeneic stem cell transplant (allo-SCT) complications. We analyzed the relationship between the interindividual variability in inflammasome protein-encoding genes in donors and patients and clinical outcome after allo-SCT. Fourteen common genetic variants in 5 genes of the inflammasome, namely, NLRP1, NLRP2, NLRP3, CARD8, and CASP5, were genotyped in 133 human leukocyte antigen-identical sibling pairs undergoing allo-SCT. In the multivariate analysis, donor variants in NLRP2 and NLRP3 were the most important prognostic factors for the clinical outcome after allo-SCT. Thus, donor TT genotype at rs10925027 in NLRP3 was associated with disease relapse (odds ratio (OR) = 6.3, P = 1 x 10(-7)), and donor GG genotype at rs1043684 in NLRP2 was associated with nonrelapse mortality (OR = 4.4, P = 6 x 10(-4)) and overall survival (OR = 3.1, P = .001). In addition, patient AA genotype at rs5862 in NLRP1 was associated with nonrelapse mortality (OR = 2.8, P = .005) and overall survival (OR = 2.0, P = .009). These results suggest that inflammasome genetic variants are important prognostic factors for the outcome of allo-SCT. If validated in larger studies, including unrelated allo-SCT, NLRPs genotype would become an important factor in donor selection., Peer Reviewed, Postprint (published version)

Published
2008

215. Fatal Immune Hemolytic Anemia Following Allogeneic Stem Cell Transplantation: Report of 2 Cases and Review of Literature

Author

Rovira, Jordina, primary, Cid, Joan, additional, Gutiérrez-García, Gonzalo, additional, Pereira, Arturo, additional, Fernández-Avilés, Francesc, additional, Rosiñol, Laura, additional, Martínez, Carmen, additional, Carreras, Enric, additional, Urbano, Álvaro, additional, Rovira, Montserrat, additional, and Lozano, Miguel, additional

Published
2013
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216. Impact of Hyperferritinemia on the Outcome of Reduced-Intensity Conditioning Allogeneic Hematopoietic Cell Transplantation for Lymphoid Malignancies

Author

Barba, Pere, primary, Valcárcel, David, additional, Pérez-Simón, José Antonio, additional, Fernández-Avilés, Francesc, additional, Piñana, José Luis, additional, Martino, Rodrigo, additional, López-Anglada, Lucía, additional, Rovira, Montserrat, additional, Garcia-Cadenas, Irene, additional, Novelli, Silvana, additional, Carreras, Enric, additional, López Corral, Lucía, additional, and Sierra, Jorge, additional

Published
2013
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217. Stem cell transplantation can provide durable disease control in blastic plasmacytoid dendritic cell neoplasm: a retrospective study from the European Group for Blood and Marrow Transplantation

Author

Roos-Weil, Damien, primary, Dietrich, Sascha, additional, Boumendil, Ariane, additional, Polge, Emmanuelle, additional, Bron, Dominique, additional, Carreras, Enric, additional, Iriondo Atienza, Arturo, additional, Arcese, William, additional, Beelen, Dietrich W., additional, Cornelissen, Jan J., additional, Kröger, Nicolaus, additional, Milone, Giuseppe, additional, Rossi, Giuseppe, additional, Jardin, Fabrice, additional, Peters, Christina, additional, Rocha, Vanderson, additional, Sureda, Anna, additional, Mohty, Mohamad, additional, and Dreger, Peter, additional

Published
2013
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218. Defibrotide for the Treatment of Hepatic Veno-Occlusive Disease: Final Results From the International Compassionate-Use Program.

Author

Corbacioglu, Selim, Carreras, Enric, Mohty, Mohamad, Pagliuca, Antonio, Boelens, Jaap Jan, Damaj, Gandhi, Iacobelli, Massimo, Niederwieser, Dietger, Olavarría, Eduardo, Suarez, Felipe, Ruutu, Tapani, Verdonck, Leo, Hume, Robin, Nejadnik, Bijan, Lai, Chinglin, Finetto, Giorgia, and Richardson, Paul

Subjects
*HEPATIC veno-occlusive disease, *HEMATOPOIETIC stem cell transplantation, *GRAFT versus host disease, *KAPLAN-Meier estimator, *DEMOGRAPHY, *THERAPEUTICS
Abstract

Hepatic veno-occlusive disease, also called sinusoidal obstruction syndrome (VOD/SOS), is an unpredictable and potentially fatal complication of hematopoietic cell transplantation (HCT) or nontransplantation-associated chemotherapy/radiotherapy. In cases of severe hepatic VOD/SOS, typically defined by associated multiorgan failure (MOF, also known as multiorgan dysfunction ), mortality exceeds 80%. Preclinical and early clinical data have provided a rationale for defibrotide treatment in hepatic VOD/SOS. Based on this evidence and in recognition of the dismal prognosis for these patients, defibrotide was made available through an international multicenter compassionate-use program conducted from December 1998 to March 2009. Physicians participating in the program voluntarily provided demographic and outcome data for patients given defibrotide. Efficacy and safety analyses were performed using the data received for 710 treated patients. Defibrotide was given at 10, 25, 40, 60, or 80 mg/kg/day for a median of 15 days (range, 1 to 119 days). By Kaplan-Meier analysis, the estimated overall day +100 survival was 54% (58% in the 25 mg/kg/day dose group). Adverse events (AEs) were reported in 53% of patients. The most common AEs were MOF, progression of hepatic VOD/SOS, sepsis, and graft-versus-host disease, which were consistent with the AEs expected for this patient population. No clinically meaningful trends in AEs were identified by gender, age, or dose group. Safety and efficacy resultswere consistent with prior studies of defibrotide in hepatic VOD/SOS, and subgroup analyses lend support to the use of the 25 mg/kg/day dose. [ABSTRACT FROM AUTHOR]

Published
2016
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219. Improving safety of autologous haematopoietic stem cell transplantation in patients with Crohn's disease.

Author

Jauregui-Amezaga, Aranzazu, Rovira, Montserrat, Marín, Pedro, Salas, Azucena, Pinó-Donnay, Susana, Faust Feu, Elizalde, J. Ignasi, Fernández-Avilés, Francesc, Martínez, Carmen, Gutiérrez, Gonzalo, Rosiñol, Laura, Carreras, Enric, Urbano, Alvaro, Lozano, Miguel, Cid, Joan, Suárez-Lledó, María, Mensa, Josep, Rimola, Jordi, Rodríguez, Sonia, and Masamunt, Mari Carme

Subjects
HEMATOPOIETIC stem cell transplantation, CROHN'S disease, LONGITUDINAL method, ENTEROBACTERIACEAE diseases, ANTIBIOTIC prophylaxis, CYTOMEGALOVIRUS diseases, PATIENTS
Published
2016
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221. Allogeneic and syngeneic hematopoietic cell transplantation in patients with amyloid light-chain amyloidosis: a report from the European Group for Blood and Marrow Transplantation.

Author

UCL - MED - Sciences médicales, Schönland, Stefan O, Lokhorst, Henk, Buzyn, Agnes, Leblond, Veronique, Hegenbart, Ute, Bandini, Giuseppe, Campbell, Andrew, Carreras, Enric, Ferrant, Augustin, Grommisch, Leanthe, Jacobs, Peter, Kröger, Nicolaus, La Nasa, Giorgio, Russell, Nigel, Zachee, Pierre, Goldschmidt, Hartmut, Iacobelli, Simona, Niederwieser, Dietger, Gahrton, Gösta, UCL - MED - Sciences médicales, Schönland, Stefan O, Lokhorst, Henk, Buzyn, Agnes, Leblond, Veronique, Hegenbart, Ute, Bandini, Giuseppe, Campbell, Andrew, Carreras, Enric, Ferrant, Augustin, Grommisch, Leanthe, Jacobs, Peter, Kröger, Nicolaus, La Nasa, Giorgio, Russell, Nigel, Zachee, Pierre, Goldschmidt, Hartmut, Iacobelli, Simona, Niederwieser, Dietger, and Gahrton, Gösta

Abstract

Using the European Group for Blood and Marrow Transplantation (EBMT) registry, we retrospectively studied 19 patients with AL (amyloid light-chain) amyloidosis who underwent allogeneic (allo; n = 15) or syngeneic (syn; n = 4) hematopoietic stem cell transplantation (SCT) between 1991 and 2003. For allo-SCT, full-intensity conditioning was used in 7 patients and reduced-intensity conditioning (RIC) in 8 patients. Engraftment was durable in 12 of those 15 patients. The median follow-up time is 19 months. Kaplan-Meier probabilities of overall and progression-free survival were 60% and 53% at 1 year, respectively. Overall, 40% of patients died of transplant-related mortality (TRM). Best hematologic response after SCT was complete remission (CR) and partial remission (PR) in 8 and 2 patients, respectively, leading to an organ response in 8 of these patients. Seven of the 10 patients in remission are long-term survivors. In 5 of 7 evaluable patients in CR, chronic graft-versus-host disease (GvHD) was observed, indicating the contribution of immune effects to disease control. The main clinical problem was cardiac failure in patients with poor performance status due to amyloidosis or in combination with severe infections. These data suggest that allo-SCT might be a promising and potentially curative treatment modality for selected patients with AL amyloidosis.

Published
2006

222. Drug safety evaluation of defibrotide

Author

Richardson, Paul G, primary, Corbacioglu, Selim, additional, Ho, Vincent Trien-Vinh, additional, Kernan, Nancy A, additional, Lehmann, Leslie, additional, Maguire, Craig, additional, Maglio, Michelle, additional, Hoyle, Margaret, additional, Sardella, Marco, additional, Giralt, Sergio, additional, Holler, Ernst, additional, Carreras, Enric, additional, Niederwieser, Dietger, additional, and Soiffer, Robert, additional

Published
2012
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223. The Combination of the EBMT Score and the HCT-CI Is Not Better Than the HCT-CI Alone in the Prediction of NRM and OS in Patients Undergoing Allogeneic Hematopoietic Transplantation with Reduced-Toxicity Conditioning

Author

Barba, Pere, primary, Valcarcel, David, additional, López-Corral, Lucía, additional, fernandez-Aviles, Francesc, additional, Martino, Rodrigo, additional, Cabrero, Monica, additional, Rovira, Montserrat, additional, Pinana, jose Luis, additional, Brunet, Salut, additional, Carreras, Enric, additional, Caballero, maria Dolores, additional, and Sierra, Jorge, additional

Published
2012
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226. Safety and efficacy of defibrotide for the treatment of severe hepatic veno-occlusive disease

Author

Richardson, Paul G., primary, Ho, Vincent T., additional, Giralt, Sergio, additional, Arai, Sally, additional, Mineishi, Shin, additional, Cutler, Corey, additional, Antin, Joseph H., additional, Stavitzski, Nicole, additional, Niederwieser, Dietger, additional, Holler, Ernst, additional, Carreras, Enric, additional, and Soiffer, Robert, additional

Published
2012
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227. Outcome of Second Allogeneic SCT Following Relapse of Hematological Malignancies After a First Allogeneic SCT

Author

Orti, Guillermo, primary, Sanz, Jaime, additional, Bermudez, Arancha, additional, Caballero, Dolores, additional, Martinez, Carmen, additional, Sierra, Jordi, additional, Marin, José R. Cabrera, additional, Espigado, Ildefonso, additional, Solano, Carlos, additional, Ferrà, Christelle, additional, García-Noblejas, Ana, additional, Jimenez, Santiago, additional, Sampol, Antonia, additional, Duarte, Monica Lopez, additional, Garcia, Valentin, additional, Pascual, Maria Jesus, additional, Jurado, Manuel, additional, Moraleda, José M., additional, Sanz, Miguel A., additional, Carreras, Enric, additional, and Duarte, Rafael F., additional

Published
2011
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228. Stem Cell Transplantation Can Provide Durable Disease Control in Blastic Plasmacytoid Dendritic Cell Neoplasia (BPDC): A Retrospective Study From the European Group for Blood and Marrow Transplantation (EBMT)

Author

Dietrich, Sascha, primary, Roos-Weil, Damien, additional, Boumendil, Ariane, additional, Polge, Emanuelle, additional, Luan, Jian-Jian, additional, Bron, Dominique, additional, Carreras, Enric, additional, Atienza, Arturo Iriondo, additional, Arcese, William, additional, Beelen, Dietrich, additional, Cornelissen, Jan J, additional, Kröger, Nicolaus, additional, Milone, Giuseppe, additional, Rossi, Giuseppe, additional, Tilly, Herve, additional, Vernant, Jean Paul, additional, Rocha, Vanderson, additional, Sureda, Anna, additional, Mohty, Mohamad, additional, and Dreger, Peter, additional

Published
2011
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232. Pretransplantation Liver Function Impacts on the Outcome of Allogeneic Hematopoietic Stem Cell Transplantation: A Study of 455 Patients

Author

Barba, Pere, primary, Piñana, José Luis, additional, Fernández-Avilés, Francesc, additional, Perez-Simón, Jose Antonio, additional, Martino, Rodrigo, additional, López-Guerrero, Eva, additional, Valcárcel, David, additional, Rovira, Montserrat, additional, Novelli, Silvana, additional, Campos-Varela, Isabel, additional, López-Anglada, Lucía, additional, Vidal, Xavier, additional, López Corral, Lucía, additional, Carreras, Enric, additional, and Sierra, Jorge, additional

Published
2011
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233. Liquid pearls

Author

Bremond, Nicolas, primary, Santanach-Carreras, Enric, additional, and Bibette, Jérôme, additional

Published
2011
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236. Update on fungemia in oncology and hematology

Author

Carreras, Enric, primary, Vázquez, Lourdes, additional, Rodríguez Tudela, José Luis, additional, Pahisa, Albert, additional, Azanza, José Ramón, additional, Rovira, Montserrat, additional, and de la Cámara, Rafael, additional

Published
2011
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237. Hepatic Toxicity After Reduced-Intensity Conditioning Allogeneic Stem Cell Transplantation: Incidence, Characteristics and Risk Factors In a Cohort of 452 Patients.

Author

Barba, Pere, primary, Martino, Rodrigo, additional, Pinana, jose Luis, additional, Perez-Simon, Jose Antonio, additional, fernandez-Aviles, Francesc, additional, Valcarcel, David, additional, Rovira, Montserrat, additional, Lopez-Anglada, Lucia, additional, Novelli, Silvana, additional, Carreras, Enric, additional, and Sierra, Jorge, additional

Published
2010
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238. Incidence and Risk Factors for Secondary Autoimmune Diseases (AD) After Hematopoietic Stem Cell Transplantation (HSCT) for a Severe Autoimmune Disease-A Retrospective EBMT WP AD Study

Author

Daikeler, Thomas, primary, Labopin, Myriam, additional, di Gioia, Massimo, additional, Abinun, Mario, additional, Alexander, Tobias, additional, Miniati, Irene, additional, Gualandi, Francesca, additional, Fassas, Athanasios, additional, Martin, Thierry, additional, Schwarze, Carl-Philipp, additional, Wulffraat, Nico, additional, Buch, Maya, additional, Sampol, Antonia, additional, Carreras, Enric, additional, Dubois, Benedict, additional, Gruhn, Bernd, additional, Güngör, Tayfun, additional, Pohlreich, David, additional, Schuerwegh, Annemie, additional, Snarsky, Emilian, additional, Snowden, John, additional, Veys, Paul, additional, Fasth, Anders, additional, Lenhoff, Stig, additional, Messina, Chiara, additional, Voswinkel, Jan, additional, Badoglio, Manuela, additional, Henes, Jörg, additional, Launay, David, additional, Tyndall, Alan, additional, Gluckman, Eliane, additional, and Farge, Dominique, additional

Published
2010
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240. 148-P: Populations

Author

Klitz, William, primary, Gragert, Loren, additional, Martin, Maiers, additional, and Carreras, Enric, additional

Published
2010
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242. Unrelated Transplantation for Poor-Prognosis Adult Acute Lymphoblastic Leukemia: Long-Term Outcome Analysis and Study of the Impact of Hematopoietic Graft Source

Author

Ferrá, Christelle, primary, Sanz, Jaime, additional, de la Cámara, Rafael, additional, Sanz, Guillermo, additional, Bermúdez, Arancha, additional, Valcárcel, David, additional, Rovira, Montserrat, additional, Serrano, David, additional, Caballero, Dolores, additional, Espigado, Ildefonso, additional, Morgades, Mireia, additional, Heras, Inmaculada, additional, Solano, Carlos, additional, Duarte, Rafael, additional, Barrenetxea, Cristina, additional, García-Noblejas, Ana, additional, Díez-Martin, José L., additional, Iriondo, Arturo, additional, Carreras, Enric, additional, Sierra, Jordi, additional, Sanz, Miguel-Ángel, additional, and Ribera, Josep-Maria, additional

Published
2010
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244. Hepatic Veno-Occlusive Disease following Stem Cell Transplantation: Incidence, Clinical Course, and Outcome

Author

Coppell, Jason A., primary, Richardson, Paul G., additional, Soiffer, Robert, additional, Martin, Paul L., additional, Kernan, Nancy A., additional, Chen, Allen, additional, Guinan, Eva, additional, Vogelsang, Georgia, additional, Krishnan, Amrita, additional, Giralt, Sergio, additional, Revta, Carolyn, additional, Carreau, Nicole A., additional, Iacobelli, Massimo, additional, Carreras, Enric, additional, Ruutu, Tapani, additional, Barbui, Tiziano, additional, Antin, Joseph H., additional, and Niederwieser, Dietger, additional

Published
2010
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247. Unrelated Cord Blood Transplantation (UCBT) in Adults with MDS or Secondary Acute Myeloblastic Leukemia (sAML): a Survey On Behalf of Eurocord and CLWP of EBMT.

Author

Robin, Marie, primary, Sanz, Guillermo, additional, Ionescu, Irina, additional, Rio, Bernard, additional, Sirvent, Anne, additional, Renaud, Marc, additional, Carreras, Enric, additional, Milpied, Noel-Jean, additional, de Witte, T. M., additional, Picardi, Alessandra, additional, Gluckman, Eliane, additional, Kroger, Nicolaus, additional, and Rocha, Vanderson, additional

Published
2009
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249. Beta-2 Microglobulin Is a Strong Prognostic Marker in Patients with Chronic Lymphocytic Leukemia Submitted to Allogeneic Stem Cell Transplantation.

Author

Moreno, Carol, primary, Hodgson, Kate E, additional, Rovira, Montserrat, additional, Esteve, Jordi, additional, Martinez, Carmen, additional, Fernandez, Francesc, additional, Ferrer, Gerardo, additional, Gel, Bernat, additional, Carreras, Enric, additional, Bosch, Francesc, additional, and Montserrat, Emili, additional

Published
2009
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250. The Release of Soluble Factors Contributing to Endothelial Activation and Damage after Hematopoietic Stem Cell Transplantation Is Not Limited to the Allogeneic Setting and Involves Several Pathogenic Mechanisms

Author

Palomo, Marta, primary, Diaz-Ricart, Maribel, additional, Carbo, Carla, additional, Rovira, Montserrat, additional, Fernandez-Aviles, Francesc, additional, Escolar, Gines, additional, Eissner, Günther, additional, Holler, Ernst, additional, and Carreras, Enric, additional

Published
2009
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