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Item does not contain fulltext, OBJECTIVE: To develop new composite disease activity indices for psoriatic arthritis (PsA). METHODS: Data from routine clinic visits at multiple centres were collected in a systematic manner. Data included all domains identified as important in randomised controlled trials in PsA. Decisions to change treatment were used as surrogates for high disease activity. New indices were developed by multiple linear regression (psoriatic arthritis disease activity score: PASDAS) and empirically, utilising physician-defined cut-offs for disease activity (arithmetic mean of desirability functions: AMDF). These were compared with existing composite measures: Composite Psoriatic arthritis Disease Activity Index (CPDAI), Disease Activity for PSoriatic Arthritis (DAPSA), and Disease Activity Score for rheumatoid arthritis (DAS28). RESULTS: 161/503 (32%) subjects had treatment changes. Although all measures performed well, compared with existing indices, PASDAS was better able to discriminate between high and low disease activity (area under receiver operating curves (ROC)) curve with 95% CI: PASDAS 0.773 (0.723, 0.822); AMDF 0.730 (0.680, 0.780); CPDAI 0.719 (0.668, 0.770); DAPSA 0.710 (0.654, 0.766); DAS28 0.736 (0.680, 0.792). All measures were able to discriminate between disease activity states in patients with oligoarthritis, although area under the receiver operating curves (AUC) were generally smaller. In patients with severe skin disease (psoriasis area and severity index >10) both nonparametric and AUC curve statistics were nonsignificant for all measures. CONCLUSIONS: Two new composite measures to assess disease activity in PsA have been developed. Further testing in other datasets, including comparison with existing measures, is required to validate these instruments.

The split of a generalised Chaplygin gas with an equation of state p = -A/\rho^{\alpha} into an interacting mixture of pressureless matter and a dark-energy component with equation of state p_{\Lambda} = - \rho_{\Lambda} implies the existence of non-adiabatic pressure perturbations. We demonstrate that the square of the effective (non-adiabatic) sound speed c_s of the medium is proportional to the ratio of the perturbations of the dark energy to those of the dark matter. Since, as demonstrated explicitly for the particular case \alpha = -1/2, dark-energy perturbations are negligible compared with dark-matter perturbations on scales that are relevant for structure formation, we find |c_s^2| << 1. Consequently, there are no oscillations or instabilities which have plagued previous adiabatic Chaplygin-gas models., Comment: Version to appear in Physics Letters B

In this paper we study an anisotropic model generated from a particular Bianchi type-III metric, which is a generalization of G\"odel's metric and an exact solution of Einstein's field equations. We analyse type Ia supernova data, namely the SDSS sample calibrated with the MLCS2k2 fitter, and we verify in which ranges of distances and redshifts the anisotropy could be observed. We also consider, in a joint analysis, the position of the first peak in the CMB anisotropy spectrum, as well as current observational constraints on the Hubble constant. We conclude that a small anisotropy is permitted by the data, and that more accurate measurements of supernova distances above z = 2 might indicate the existence of such anisotropy in the universe., Comment: Revised version, to appear in JCAP

We demonstrate that creation of dark-matter particles at a constant rate implies the existence of a cosmological term that decays linearly with the Hubble rate. We discuss the cosmological model that arises in this context and test it against observations of the first acoustic peak in the cosmic microwave background (CMB) anisotropy spectrum, the Hubble diagram for supernovas of type Ia (SNIa), the distance scale of baryonic acoustic oscillations (BAO) and the distribution of large scale structures (LSS). We show that a good concordance is obtained, albeit with a higher value of the present matter abundance than in the \Lambda CDM model. We also comment on general features of the CMB anisotropy spectrum and on the cosmic coincidence problem., Comment: Revised version. Accepted for publication in Physics Letters B

We investigate a spatially flat Friedmann-Lema\^itre-Robertson-Walker cosmology in which a decaying vacuum term causes matter production at late times. Assuming a decay proportional to the Hubble rate, the ratio of the background energy densities of dark matter and dark energy changes with the cosmic scale factor as $a^{-3/2}$. The intrinsically non-adiabatic two-component perturbation dynamics of this model is reduced to a single second-order equation. Perturbations of the vacuum term are shown to be negligible on scales that are relevant for structure formation. On larger scales, dark-energy perturbations give a somewhat higher contribution but remain always smaller than the dark-matter perturbations., Comment: 13 pages, 4 figures, discussion of initial conditions enlarged, accepted for publication in JCAP

We investigate the observational viability of a class of cosmological models in which the vacuum energy density decays linearly with the Hubble parameter, resulting in a production of cold dark matter particles at late times. Similarly to the flat \Lambda CDM case, there is only one free parameter to be adjusted by the data in this class of \Lambda(t)CDM scenarios, namely, the matter density parameter. To perform our analysis we use three of the most recent SNe Ia compilation sets (Union2, SDSS and Constitution) along with the current measurements of distance to the BAO peaks at z = 0.2 and z = 0.35 and the position of the first acoustic peak of the CMB power spectrum. We show that in terms of $\chi^2$ statistics both models provide good fits to the data and similar results. A quantitative analysis discussing the differences in parameter estimation due to SNe light-curve fitting methods (SALT2 and MLCS2k2) is studied using the current SDSS and Constitution SNe Ia compilations. A matter power spectrum analysis using the 2dFGRS is also performed, providing a very good concordance with the constraints from the SDSS and Constitution MLCS2k2 data., Comment: Revised version, to appear in JCAP

We extend the results of a previous paper where a model of interacting dark energy, with a cosmological term decaying linearly with the Hubble parameter, is tested against the observed mass power spectrum. In spite of the agreement with observations of type Ia supernovas, baryonic acoustic oscillations and the cosmic microwave background, we had shown previously that no good concordance is achieved if we include the mass power spectrum. However, our analysis was based on the ad hoc assumption that the interacting cosmological term is strictly homogeneous. Now we perform a more complete analysis, by perturbing such a term. Although our conclusions are still based on a particular, scale invariant choice of the primordial spectrum of dark energy perturbations, we show that a cosmological term decaying linearly with the Hubble parameter is indeed disfavored as compared to the standard model., Comment: Version accepted for publication in Physical Review D

We study cosmological perturbations in the context of an interacting dark energy model, in which the cosmological term decays linearly with the Hubble parameter, with concomitant matter production. A previous joint analysis of the redshift-distance relation for type Ia supernovas, baryonic acoustic oscillations, and the position of the first peak in the anisotropy spectrum of the cosmic microwave background has led to acceptable values for the cosmological parameters. Here we present our analysis of small perturbations, under the assumption that the cosmological term, and therefore the matter production, are strictly homogeneous. Such a homogeneous production tends to dilute the matter contrast, leading to a late-time suppression in the power spectrum. Nevertheless, an excellent agreement with the observational data can be achieved by using a higher matter density as compared to the concordance value previously obtained. This may indicate that our hypothesis of homogeneous matter production must be relaxed by allowing perturbations in the interacting cosmological term., Comment: Revised version. To appear in Physical Review D

The cosmological constant, i.e., the energy density stored in the true vacuum state of all existing fields in the Universe, is the simplest and the most natural possibility to describe the current cosmic acceleration. However, despite its observational successes, such a possibility exacerbates the well known cosmological constant problem, requiring a natural explanation for its small, but nonzero, value. In this paper we study cosmological consequences of a scenario driven by a varying cosmological term, in which the vacuum energy density decays linearly with the Hubble parameter. We test the viability of this scenario and study a possible way to distinguish it from the current standard cosmological model by using recent observations of type Ia supernova (Supernova Legacy Survey Collaboration), measurements of the baryonic acoustic oscillation from the Sloan Digital Sky Survey and the position of the first peak of the cosmic microwave background angular spectrum from the three-year Wilkinson Microwave Anisotropy Probe., Comment: Some important revisions. To appear in Physical Review D

We investigate cosmological solutions of Brans-Dicke theory with both the vacuum energy density and the gravitational constant decaying linearly with the Hubble parameter. A particular class of them, with constant deceleration factor, sheds light on the cosmological constant problems, leading to a presently small vacuum term, and to a constant ratio between the vacuum and matter energy densities. By fixing the only free parameter of these solutions, we obtain cosmological parameters in accordance with observations of both the relative matter density and the universe age. In addition, we have three other solutions, with Brans-Dicke parameter w = -1 and negative cosmological term, two of them with a future singularity of big-rip type. Although interesting from the theoretical point of view, two of them are not in agreement with the observed universe. The third one leads, in the limit of large times, to a constant relative matter density, being also a possible solution to the cosmic coincidence problem., Comment: Minor changes, references added. Version accepted for publication in Classical and Quantum Gravity

There is mounting observational evidence that the expansion of our Universe is undergoing a late-time acceleration. Among many proposals to describe this phenomenon, the cosmological constant seems to be the simplest and the most natural explanation. However, despite its observational successes, such a possibility exacerbates the well known cosmological constant problem, requiring a natural explanation for its small, but nonzero, value. In this paper we consider a cosmological scenario driven by a varying cosmological term, in which the vacuum energy density decays linearly with the Hubble parameter. We show that this model is indistinguishable from the standard one in that the early radiation phase is followed by a long dust-dominated era, and only recently the varying cosmological term becomes dominant, accelerating the cosmic expansion. In order to test the viability of this scenario we have used the most recent type Ia supernova data, i.e., the High-Z SN Search (HZS) Team and the Supernova Legacy Survey (SNLS) Collaboration data. In particular, for the SNLS sample we have found the present matter density and Hubble parameters in the intervals [0.27, 0.37] and [0.68, 0.72], respectively (at 95% c.l.), which is in good agreement with the currently accepted estimates for these parameters., Comment: Version accepted for publication in Physical Review D

Among the several proposals to solve the incompatibility between the observed small value of the cosmological constant and the huge value obtained by quantum field theories, we can find the idea of a decaying vacuum energy density, leading from high values at early times of universe evolution to the small value observed nowadays. In this paper we consider a variation law for the vacuum density recently proposed by Schutzhold on the basis of quantum field estimations in the curved, expanding background, characterized by a vacuum density proportional to the Hubble parameter. We show that, in the context of an isotropic and homogeneous, spatially flat model, the corresponding solutions retain the well established features of the standard cosmology, and, in addition, are in accordance with the observed cosmological parameters. Our scenario presents an initial phase dominated by radiation, followed by a dust era long enough to permit structure formation, and by an epoch dominated by the cosmological term, which tends asymptotically to a de Sitter universe. Taking the matter density equals to half of the vacuum energy density, as suggested by observation, we obtain a universe age given by Ht = 1.1, and a decelerating parameter equals to -1/2., Comment: Accepted for publication in General Relativity and Gravitation

We present some cosmological solutions of Brans-Dicke theory, characterized by a decaying vacuum energy density and by a constant relative matter density. With these features, they shed light on the cosmological constant problems, leading to a presently small vacuum term, and to a constant ratio between the vacuum and matter energy densities. By fixing the only free parameter of our solutions, we obtain cosmological parameters in accordance with observations of the relative matter density, the universe age and redshift-distance relations., Comment: To appear in Brazilian Journal of Physics (proceedings of the conference 100 Years of Relativity, Sao Paulo, August 2005)

In the present contribution we show that the introduction of a conserved axial current in electrodynamics can explain the quantization of electric charge, inducing at the same time a dynamical quantization of spacetime., Comment: To appear in Chaos Solitons & Fractals

We discuss a class of uniform and isotropic, spatially flat, decaying Lambda cosmologies, in the realm of a model where the gravitation constant G is a function of the cosmological time. Besides the usual de Sitter solution, the models at late times are characterized by a constant ratio between the matter and total energy densities. One of them presents a coasting expansion where the matter density parameter is equal to 1/3, and the age of the universe satisfies Ht = 1. From considerations in line with the holographic conjecture, it is argued that, among the non-decelerating solutions, the coasting expansion is the only acceptable from a thermodynamic viewpoint, and that the time varying cosmological term must be proportional to the square of the Hubble parameter, a result earlier obtained using different arguments., Comment: Minor changes. A short version will appear in the Int. J. Mod. Phys. A (Proceedings of the Sixth Alexander Friedmann International Seminar on Gravitation and Cosmology, Cargese, 2004)

In the present work we show that planetary mean distances can be calculated with the help of a Schrodinger-type diffusion equation. The obtained results are shown to agree with the observed orbits of all the planets and of the asteroid belt in the solar system, with only three empty states. Furthermore, the equation solutions predict a fundamental orbit at 0.05 AU from solar-type stars, a result confirmed by recent discoveries. In contrast to other similar approaches previously presented in the literature, we take into account the flatness of the solar system, by considering the flat solutions of the Schrodinger-type equation. The model has just one input parameter, given by the mean distance of Mercury., Comment: 6 pages. Version accepted for publication in Chaos, Solitons & Fractals