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1,068 results on '"Carbone S."'

206. Ruolo della nicotina

Author

Carbone, S. and Gumina, Stefano

Subjects
ruolo patologico della nicotina, fattori predisponenti rottura cuffia rotatori
Published
2012

219. Trattamento artroscopico: 'relive'

Author

Gumina, Stefano and Carbone, S.

Subjects
trattamento instabilità spalla, tecnica relive instabilità spalla
Published
2011

226. Comparative safety of interleukin-1 blockade with anakinra in patients with ST-segment elevation acute myocardial infarction (from the VCU-ART and VCU-ART2 pilot studies)

Author

Abbate, A., Kontos, M.C., Abouzaki, N.A., Melchior, R.D., Thomas, C., Tassell, B.W. Van, Oddi, C., Carbone, S., Trankle, C.R., Roberts, C.S., Mueller, G.H., Gambill, M.L., Christopher, S., Markley, R., Vetrovec, G.W., Dinarello, C.A., Biondi-Zoccai, G., Abbate, A., Kontos, M.C., Abouzaki, N.A., Melchior, R.D., Thomas, C., Tassell, B.W. Van, Oddi, C., Carbone, S., Trankle, C.R., Roberts, C.S., Mueller, G.H., Gambill, M.L., Christopher, S., Markley, R., Vetrovec, G.W., Dinarello, C.A., and Biondi-Zoccai, G.

Abstract

Item does not contain fulltext, Two pilot studies of interleukin-1 (IL-1) blockade in ST-segment elevation myocardial infarction (STEMI) showed blunted acute inflammatory response and overall favorable outcomes at 3 months follow-up. We hereby present a patient-level pooled analysis with extended follow-up of 40 patients with clinically stable STEMI randomized to anakinra, a recombinant IL-1 receptor antagonist, 100 mg/day for 14 days or placebo in a double-blinded fashion. End points included death, cardiac death, recurrent acute myocardial infarction (AMI), stroke, unstable angina, and symptomatic heart failure. Median follow-up was 28 (interquartile range 3 to 38) months. Sixteen patients (40%) had a total of 22 adverse cardiovascular events: 1 cardiac death, 4 recurrent AMI, 5 episodes of unstable angina pectoris requiring hospitalization and/or urgent revascularization, and 11 new diagnoses of heart failure. Treatment with anakinra was associated with a hazard ratio of 1.08 (95% confidence interval 0.31 to 3.74, p = 0.90) for the combined end point of death, recurrent AMI, unstable angina pectoris, or stroke and a hazard ratio of 0.16 (95% confidence interval 0.03 to 0.76, p = 0.008) for death or heart failure. In conclusion, IL-1 blockade with anakinra for 2 weeks appears, therefore, to have a neutral effect on recurrent ischemic events, whereas it may prevent new-onset heart failure long term after STEMI.

Published
2015

227. Effects of Prolastin C (Plasma-Derived Alpha-1 Antitrypsin) on the acute inflammatory response in patients with ST-segment elevation myocardial infarction (from the VCU-alpha 1-RT pilot study)

Author

Abbate, A., Tassell, B.W. Van, Christopher, S., Abouzaki, N.A., Sonnino, C., Oddi, C., Carbone, S., Melchior, R.D., Gambill, M.L., Roberts, C.S., Kontos, M.C., Peberdy, M.A., Toldo, S., Vetrovec, G.W., Biondi-Zoccai, G., Dinarello, C.A., Abbate, A., Tassell, B.W. Van, Christopher, S., Abouzaki, N.A., Sonnino, C., Oddi, C., Carbone, S., Melchior, R.D., Gambill, M.L., Roberts, C.S., Kontos, M.C., Peberdy, M.A., Toldo, S., Vetrovec, G.W., Biondi-Zoccai, G., and Dinarello, C.A.

Abstract

Item does not contain fulltext, Alpha-1 antitrypsin (AAT) has broad anti-inflammatory and immunomodulating properties in addition to inhibiting serine proteases. Administration of human plasma-derived AAT is protective in models of acute myocardial infarction in mice. The objective of this study was to determine the safety and tolerability of human plasma-derived AAT and its effects on the acute inflammatory response in non-AAT deficient patients with ST-segment elevation myocardial infarction (STEMI). Ten patients with acute STEMI were enrolled in an open-label, single-arm treatment study of AAT at 60 mg/kg infused intravenously within 12 hours of admission and following standard of care treatment. C-reactive protein (CRP) and plasma AAT levels were determined at admission, 72 hours, and 14 days, and patients were followed clinically for 12 weeks for the occurrence of new onset heart failure, recurrent myocardial infarction, or death. Twenty patients with STEMI enrolled in previous randomized trials with identical inclusion and/or exclusion criteria, but who received placebo, served as historical controls. Prolastin C was well tolerated and there were no in-hospital adverse events. Compared with historical controls, the area under the curve of CRP levels was significantly lower 14 days after admission in the Prolastin C group (75.9 [31.4 to 147.8] vs 205.6 [78.8 to 410.9] mg/l, p = 0.048), primarily due to a significant blunting of the increase occurring between admission and 72 hours (delta CRP +1.7 [0.2 to 9.4] vs +21.1 [3.1 to 38.0] mg/l, p = 0.007). Plasma AAT levels increased from admission (149 [116 to 189]) to 203 ([185 to 225] mg/dl) to 72 hours (p = 0.005). In conclusion, a single administration of Prolastin C in patients with STEMI is well tolerated and is associated with a blunted acute inflammatory response.

Published
2015

228. Characterization of trace metals on soot aerosol particles with the SP-AMS

Author

University of Helsinki, Department of Physics (-2009), University of Helsinki, Department of Physics, Carbone, S., Onasch, T., Saarikoski, S., Timonen, H., Saarnio, K., Sueper, D., Ronkko, T., Pirjola, L., Häyrinen, A., Worsnop, D., Hillamo, R., University of Helsinki, Department of Physics (-2009), University of Helsinki, Department of Physics, Carbone, S., Onasch, T., Saarikoski, S., Timonen, H., Saarnio, K., Sueper, D., Ronkko, T., Pirjola, L., Häyrinen, A., Worsnop, D., and Hillamo, R.

Abstract

A method to detect and quantify mass concentrations of trace metals on soot particles by the Aerodyne soot-particle aerosol mass spectrometer (SP-AMS) was developed and evaluated in this study. The generation of monodisperse Regal black (RB) test particles with trace amounts of 13 different metals (Na, Al, Ca, V, Cr, Mn, Fe, Ni, Cu, Zn, Rb, Sr and Ba) allowed for the determination of the relative ionization efficiency of each metal relative to black carbon (RIEmeas). The observed RIEmeas/RIEtheory values were larger than unity for Na, Rb, Ca, Sr and Ba due to thermal surface ionization (TSI) on the surface of the laser-heated RB particles. Values closer to unity were obtained for the transition metals Zn, Cu, V and Cr. Mn, Fe, and Ni presented the lowest RIEmeas/RIEtheory ratios and highest deviation from unity. The latter discrepancy is unexplained; however it may be related to problems with our calibration method and/or the formation of metal complexes that were not successfully quantified. The response of the metals to the laser power was investigated and the results indicated that a minimum pump laser current of 0.6 A was needed in order to vaporize the metals and the refractory black carbon (rBC). Isotopic patterns of metals were resolved from high-resolution mass spectra, and the mass-weighted size distributions for each individual metal ion were obtained using the high-resolution particle time-of-flight (HR-PToF) method. The RIEmeas values obtained in this study were applied to the data of emission measurements in a heavy-fuel-oil-fired heating station. Emission measurements revealed a large number of trace metals, including evidence for metal oxides and metallic salts, such as vanadium sulfate, calcium sulfate, iron sulfate and barium sulfate, which were identified in the SP-AMS high-resolution mass spectra. SP-AMS measurements of Ba, Fe, and V agreed with ICP-MS analyzed filter samples within a factor of 2 when emitted rBC mass loadings were elevated.

Published
2015

229. A new methodology to assess the performance and uncertainty of source apportionment models II: The results of two European intercomparison exercises

Author

Belis, C, Karagulian, F, Amato, F, Almeida, M, Artaxo, P, Beddows, D, Bernardoni, V, Bove, M, Carbone, S, Cesari, D, Contini, D, Cuccia, E, Diapouli, E, Eleftheriadis, K, Favez, O, El Haddad, I, Harrison, R, Hellebust, S, Hovorka, J, Jang, E, Jorquera, H, Kammermeier, T, Karl, M, Lucarelli, F, Mooibroek, D, Nava, S, Nøjgaard, J, Paatero, P, Pandolfi, M, Perrone, M, Petit, J, Pietrodangelo, A, Pokorná, P, Prati, P, Prevot, A, Quass, U, Querol, X, Saraga, D, Sciare, J, Sfetsos, A, Valli, G, Vecchi, R, Vestenius, M, Yubero, E, Hopke, P, Belis, CA, Beddows, D. C. S, Bove, MC, Harrison, RM, Nøjgaard, J. K, PERRONE, MARIA GRAZIA, Petit, JE, Prevot, ASH, Hopke, PK, Belis, C, Karagulian, F, Amato, F, Almeida, M, Artaxo, P, Beddows, D, Bernardoni, V, Bove, M, Carbone, S, Cesari, D, Contini, D, Cuccia, E, Diapouli, E, Eleftheriadis, K, Favez, O, El Haddad, I, Harrison, R, Hellebust, S, Hovorka, J, Jang, E, Jorquera, H, Kammermeier, T, Karl, M, Lucarelli, F, Mooibroek, D, Nava, S, Nøjgaard, J, Paatero, P, Pandolfi, M, Perrone, M, Petit, J, Pietrodangelo, A, Pokorná, P, Prati, P, Prevot, A, Quass, U, Querol, X, Saraga, D, Sciare, J, Sfetsos, A, Valli, G, Vecchi, R, Vestenius, M, Yubero, E, Hopke, P, Belis, CA, Beddows, D. C. S, Bove, MC, Harrison, RM, Nøjgaard, J. K, PERRONE, MARIA GRAZIA, Petit, JE, Prevot, ASH, and Hopke, PK

Abstract

The performance and the uncertainty of receptor models (RMs) were assessed in intercomparison exercises employing real-world and synthetic input datasets. To that end, the results obtained by different practitioners using ten different RMs were compared with a reference. In order to explain the differences in the performances and uncertainties of the different approaches, the apportioned mass, the number of sources, the chemical profiles, the contribution-to-species and the time trends of the sources were all evaluated using the methodology described in Belis et al. (2015). In this study, 87% of the 344 source contribution estimates (SCEs) reported by participants in 47 different source apportionment model results met the 50% standard uncertainty quality objective established for the performance test. In addition, 68% of the SCE uncertainties reported in the results were coherent with the analytical uncertainties in the input data. The most used models, EPA-PMF v.3, PMF2 and EPA-CMB 8.2, presented quite satisfactory performances in the estimation of SCEs while unconstrained models, that do not account for the uncertainty in the input data (e.g. APCS and FA-MLRA), showed below average performance. Sources with well-defined chemical profiles and seasonal time trends, that make appreciable contributions (>10%), were those better quantified by the models while those with contributions to the PM mass close to 1% represented a challenge. The results of the assessment indicate that RMs are capable of estimating the contribution of the major pollution source categories over a given time window with a level of accuracy that is in line with the needs of air quality management.

Published
2015

230. Supplementary material to "European air quality modelled by CAMx including the volatility basis set scheme"

Author

Ciarelli, G., primary, Aksoyoglu, S., additional, Crippa, M., additional, Jimenez, J. L., additional, Nemitz, E., additional, Sellegri, K., additional, Äijälä, M., additional, Carbone, S., additional, Mohr, C., additional, O'Dowd, C., additional, Poulain, L., additional, Baltensperger, U., additional, and Prévôt, A. S. H., additional

Published
2015
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233. Characterization of a real-time tracer for isoprene epoxydiols-derived secondary organic aerosol (IEPOX-SOA) from aerosol mass spectrometer measurements

Author

Hu, W. W., primary, Campuzano-Jost, P., additional, Palm, B. B., additional, Day, D. A., additional, Ortega, A. M., additional, Hayes, P. L., additional, Krechmer, J. E., additional, Chen, Q., additional, Kuwata, M., additional, Liu, Y. J., additional, de Sá, S. S., additional, McKinney, K., additional, Martin, S. T., additional, Hu, M., additional, Budisulistiorini, S. H., additional, Riva, M., additional, Surratt, J. D., additional, St. Clair, J. M., additional, Isaacman-Van Wertz, G., additional, Yee, L. D., additional, Goldstein, A. H., additional, Carbone, S., additional, Brito, J., additional, Artaxo, P., additional, de Gouw, J. A., additional, Koss, A., additional, Wisthaler, A., additional, Mikoviny, T., additional, Karl, T., additional, Kaser, L., additional, Jud, W., additional, Hansel, A., additional, Docherty, K. S., additional, Alexander, M. L., additional, Robinson, N. H., additional, Coe, H., additional, Allan, J. D., additional, Canagaratna, M. R., additional, Paulot, F., additional, and Jimenez, J. L., additional

Published
2015
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237. The Amazon Tall Tower Observatory (ATTO) in the remote Amazon Basin: overview of first results from ecosystem ecology, meteorology, trace gas, and aerosol measurements

Author

Andreae, M. O., primary, Acevedo, O. C., additional, Araùjo, A., additional, Artaxo, P., additional, Barbosa, C. G. G., additional, Barbosa, H. M. J., additional, Brito, J., additional, Carbone, S., additional, Chi, X., additional, Cintra, B. B. L., additional, da Silva, N. F., additional, Dias, N. L., additional, Dias-Júnior, C. Q., additional, Ditas, F., additional, Ditz, R., additional, Godoi, A. F. L., additional, Godoi, R. H. M., additional, Heimann, M., additional, Hoffmann, T., additional, Kesselmeier, J., additional, Könemann, T., additional, Krüger, M. L., additional, Lavric, J. V., additional, Manzi, A. O., additional, Moran-Zuloaga, D., additional, Nölscher, A. C., additional, Santos Nogueira, D., additional, Piedade, M. T. F., additional, Pöhlker, C., additional, Pöschl, U., additional, Rizzo, L. V., additional, Ro, C.-U., additional, Ruckteschler, N., additional, Sá, L. D. A., additional, Sá, M. D. O., additional, Sales, C. B., additional, Santos, R. M. N. D., additional, Saturno, J., additional, Schöngart, J., additional, Sörgel, M., additional, de Souza, C. M., additional, de Souza, R. A. F., additional, Su, H., additional, Targhetta, N., additional, Tóta, J., additional, Trebs, I., additional, Trumbore, S., additional, van Eijck, A., additional, Walter, D., additional, Wang, Z., additional, Weber, B., additional, Williams, J., additional, Winderlich, J., additional, Wittmann, F., additional, Wolff, S., additional, and Yáñez-Serrano, A. M., additional

Published
2015
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238. Supplementary material to "Characterization of a real-time tracer for Isoprene Epoxydiols-derived Secondary Organic Aerosol (IEPOX-SOA) from aerosol mass spectrometer measurements"

Author

Hu, W. W., primary, Campuzano-Jost, P., additional, Palm, B. B., additional, Day, D. A., additional, Ortega, A. M., additional, Hayes, P. L., additional, Krechmer, J. E., additional, Chen, Q., additional, Kuwata, M., additional, Liu, Y. J., additional, de Sá, S. S., additional, Martin, S. T., additional, Hu, M., additional, Budisulistiorini, S. H., additional, Riva, M., additional, Surratt, J. D., additional, St. Clair, J. M., additional, Isaacman-Van Wertz, G., additional, Yee, L. D., additional, Goldstein, A. H., additional, Carbone, S., additional, Artaxo, P., additional, de Gouw, J. A., additional, Koss, A., additional, Wisthaler, A., additional, Mikoviny, T., additional, Karl, T., additional, Kaser, L., additional, Jud, W., additional, Hansel, A., additional, Docherty, K. S., additional, Robinson, N. H., additional, Coe, H., additional, Allan, J. D., additional, Canagaratna, M. R., additional, Paulot, F., additional, and Jimenez, J. L., additional

Published
2015
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