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1,332 results on '"Can G"'

204. AB0482 Similar efficacy of tofacitinib on disease activity in rheumatoid arthritis patients with and without previous biologicals; results from the turkbio registry

Author

Zengin, B., primary, Inanç, N., additional, Akar, S., additional, Can, G., additional, Dalkilic, E., additional, Tufan, A., additional, Senel, S., additional, Serdar Koca, S., additional, Capar, S., additional, Yarkan Tugsal, H., additional, Birlik, M., additional, Akkoc, N., additional, and Onen, F., additional

Published
2018
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206. FRI0105 Concomitant use of corticosteroids at the baseline does not affect the drug survival of abatacept in rheumatoid arthritis

Author

KOCA, S.S., primary, Öz, B., additional, Karatas, A., additional, Dalkılıç, H.E., additional, Can, G., additional, Pehlivan, Y., additional, Senel, S., additional, Yazıcı, A., additional, İnanç, N., additional, Çefle, A., additional, Ertürk, Z., additional, Akar, S., additional, Yagiz, B., additional, Göker, B., additional, Birlik, A.M., additional, and Önen, F., additional

Published
2018
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208. FRI0134 Is there any difference in ra patients for methotrexate use vs. leflunomide use as a concomitant treatment with biological and targeted synthetic dmards in turkbio registry?

Author

Inanc, N., primary, Ozen, G., additional, Yalcinkaya, Y., additional, Dalkilic, E., additional, Koca, S.S., additional, Can, G., additional, Karataş, A., additional, Pehlivan, Y., additional, Yazıcı, A., additional, Cefle, A., additional, Tufan, A., additional, Akar, S., additional, Senel, S., additional, Oz, B., additional, Akkoc, N., additional, and Onen, F., additional

Published
2018
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210. Worldwide trends in blood pressure from 1975 to 2015:a pooled analysis of 1479 population-based measurement studies with 19.1 million participants

Author

Zhou, B. (Bin), Bentham, J. (James), Di Cesare, M. (Mariachiara), Bixby, H. (Honor), Danaei, G. (Goodarz), Cowan, M. J. (Melanie J.), Paciorek, C. J. (Christopher J.), Singh, G. (Gitanjali), Hajifathalian, K. (Kaveh), Bennett, J. E. (James E.), Taddei, C. (Cristina), Bilano, V. (Ver), Carrillo-Larco, R. M. (Rodrigo M.), Djalalinia, S. (Shirin), Khatibzadeh, S. (Shahab), Lugero, C. (Charles), Peykari, N. (Niloofar), Zhang, W. Z. (Wan Zhu), Lu, Y. (Yuan), Stevens, G. A. (Gretchen A.), Riley, L. M. (Leanne M.), Bovet, P. (Pascal), Elliott, P. (Paul), Gu, D. (Dongfeng), Ikeda, N. (Nayu), Jackson, R. T. (Rod T.), Joffres, M. (Michel), Kengne, A. P. (Andre Pascal), Laatikainen, T. (Tiina), Lam, T. H. (Tai Hing), Laxmaiah, A. (Avula), Liu, J. (Jing), Miranda, J. J. (J. Jaime), Mondo, C. K. (Charles K.), Neuhauser, H. K. (Hannelore K.), Sundstrom, J. (Johan), Smeeth, L. (Liam), Soric, M. (Maroje), Woodward, M. (Mark), Ezzati, M. (Majid), Abarca-Gomez, L. (Leandra), Abdeen, Z. A. (Ziad A.), Rahim, H. A. (Hanan Abdul), Abu-Rmeileh, N. M. (Niveen M.), Acosta-Cazares, B. (Benjamin), Adams, R. (Robert), Aekplakorn, W. (Wichai), Afsana, K. (Kaosar), Aguilar-Salinas, C. A. (Carlos A.), Agyemang, C. (Charles), Ahmadvand, A. (Alireza), Ahrens, W. (Wolfgang), Al Raddadi, R. (Rajaa), Al Woyatan, R. (Rihab), Ali, M. M. (Mohamed M.), Alkerwi, A. (Ala'a), Aly, E. (Eman), Amouyel, P. (Philippe), Amuzu, A. (Antoinette), Andersen, L. B. (Lars Bo), Anderssen, S. A. (Sigmund A.), Angquist, L. (Lars), Anjana, R. M. (Ranjit Mohan), Ansong, D. (Daniel), Aounallah-Skhiri, H. (Hajer), Araujo, J. (Joana), Ariansen, I. (Inger), Aris, T. (Tahir), Arlappa, N. (Nimmathota), Aryal, K. (Krishna), Arveiler, D. (Dominique), Assah, F. K. (Felix K.), Assuncao, M. C. (Maria Cecilia F.), Avdicova, M. (Maria), Azevedo, A. (Ana), Azizi, F. (Fereidoun), Babu, B. V. (Bontha V.), Bahijri, S. (Suhad), Balakrishna, N. (Nagalla), Bandosz, P. (Piotr), Banegas, J. R. (Jose R.), Barbagallo, C. M. (Carlo M.), Barcelo, A. (Alberto), Barkat, A. (Amina), Barros, A. J. (Aluisio J. D.), Barros, M. V. (Mauro V.), Bata, I. (Iqbal), Batieha, A. M. (Anwar M.), Baur, L. A. (Louise A.), Beaglehole, R. (Robert), Ben Romdhane, H. (Habiba), Benet, M. (Mikhail), Benson, L. S. (Lowell S.), Bernabe-Ortiz, A. (Antonio), Bernotiene, G. (Gailute), Bettiol, H. (Heloisa), Bhagyalaxmi, A. (Aroor), Bharadwaj, S. (Sumit), Bhargava, S. K. (Santosh K.), Bi, Y. (Yufang), Bikbov, M. (Mukharram), Bjerregaard, P. (Peter), Bjertness, E. (Espen), Bjokelund, C. (Cecilia), Blokstra, A. (Anneke), Bo, S. (Simona), Bobak, M. (Martin), Boeing, H. (Heiner), Boggia, J. G. (Jose G.), Boissonnet, C. P. (Carlos P.), Bongard, V. (Vanina), Braeckman, L. (Lutgart), Brajkovich, I. (Imperia), Branca, F. (Francesco), Breckenkamp, J. (Juergen), Brenner, H. (Hermann), Brewster, L. M. (Lizzy M.), Bruno, G. (Graziella), Bueno-de-Mesquita, H. B. (H. B. (as)), Bugge, A. (Anna), Burns, C. (Con), Bursztyn, M. (Michael), de Leon, A. C. (Antonio Cabrera), Cameron, C. (Christine), Can, G. (Gunay), Candido, A. P. (Ana Paula C.), Capuano, V. (Vincenzo), Cardoso, V. C. (Viviane C.), Carlsson, A. C. (Axel C.), Carvalho, M. J. (Maria J.), Casanueva, F. F. (Felipe F.), Casas, J.-P. (Juan-Pablo), Caserta, C. A. (Carmelo A.), Chamukuttan, S. (Snehalatha), Chan, A. W. (Angelique W.), Chan, Q. (Queenie), Chaturvedi, H. K. (Himanshu K.), Chaturvedi, N. (Nishi), Chen, C.-J. (Chien-Jen), Chen, F. (Fangfang), Chen, H. (Huashuai), Chen, S. (Shuohua), Chen, Z. (Zhengming), Cheng, C.-Y. (Ching-Yu), Dekkaki, I. C. (Imane Cherkaoui), Chetrit, A. (Angela), Chiolero, A. (Arnaud), Chiou, S.-T. (Shu-Ti), Chirita-Emandi, A. (Adela), Cho, B. (Belong), Cho, Y. (Yumi), Chudek, J. (Jerzy), Cifkova, R. (Renata), Claessens, F. (Frank), Clays, E. (Els), Concin, H. (Hans), Cooper, C. (Cyrus), Cooper, R. (Rachel), Coppinger, T. C. (Tara C.), Costanzo, S. (Simona), Cottel, D. (Dominique), Cowell, C. (Chris), Craig, C. L. (Cora L.), Crujeiras, A. B. (Ana B.), Cruz, J. J. (Juan J.), D'Arrigo, G. (Graziella), d'Orsi, E. (Eleonora), Dallongeville, J. (Jean), Damasceno, A. (Albertino), Dankner, R. (Rachel), Dantoft, T. M. (Thomas M.), Dauchet, L. (Luc), De Backer, G. (Guy), de Gaetano, G. (Giovanni), De Henauw, S. (Stefaan), De Smedt, D. (Delphine), Deepa, M. (Mohan), Dehghan, A. (Abbas), Delisle, H. (Helene), Deschamps, V. (Valerie), Dhana, K. (Klodian), Di Castelnuovo, A. F. (Augusto F.), Dias-da-Costa, J. S. (Juvenal Soares), Diaz, A. (Alejandro), Dickerson, T. T. (Ty T.), Do, H. T. (Ha T. P.), Dobson, A. J. (Annette J.), Donfrancesco, C. (Chiara), Donoso, S. P. (Silvana P.), Doering, A. (Angela), Doua, K. (Kouamelan), Drygas, W. (Wojciech), Dulskiene, V. (Virginija), Dzakula, A. (Aleksandar), Dzerve, V. (Vilnis), Dziankowska-Zaborszczyk, E. (Elzbieta), Eggertsen, R. (Robert), Ekelund, U. (Ulf), El Ati, J. (Jalila), Ellert, U. (Ute), Elosua, R. (Roberto), Erasmus, R. T. (Rajiv T.), Erem, C. (Cihangir), Eriksen, L. (Louise), Escobedo-de la Pena, J. (Jorge), Evans, A. (Alun), Faeh, D. (David), Fall, C. H. (Caroline H.), Farzadfar, F. (Farshad), Felix-Redondo, F. J. (Francisco J.), Ferguson, T. S. (Trevor S.), Fernandez-Berges, D. (Daniel), Ferrante, D. (Daniel), Ferrari, M. (Marika), Ferreccio, C. (Catterina), Ferrieres, J. (Jean), Finn, J. D. (Joseph D.), Fischer, K. (Krista), Foeger, B. (Bernhard), Foo, L. H. (Leng Huat), Forslund, A.-S. (Ann-Sofie), Forsner, M. (Maria), Fortmann, S. P. (Stephen P.), Fouad, H. M. (Heba M.), Francis, D. K. (Damian K.), Franco, M. d. (Maria do Carmo), Franco, O. H. (Oscar H.), Frontera, G. (Guillermo), Fuchs, F. D. (Flavio D.), Fuchs, S. C. (Sandra C.), Fujita, Y. (Yuki), Furusawa, T. (Takuro), Gaciong, Z. (Zbigniew), Gareta, D. (Dickman), Garnett, S. P. (Sarah P.), Gaspoz, J.-M. (Jean-Michel), Gasull, M. (Magda), Gates, L. (Louise), Gavrila, D. (Diana), Geleijnse, J. M. (Johanna M.), Ghasemian, A. (Anoosheh), Ghimire, A. (Anup), Giampaoli, S. (Simona), Gianfagna, F. (Francesco), Giovannelli, J. (Jonathan), Goldsmith, R. A. (Rebecca A.), Goncalves, H. (Helen), Gonzalez Gross, M. (Marcela), Gonzalez Rivas, J. P. (Juan P.), Gottrand, F. (Frederic), Graff-Iversen, S. (Sidsel), Grafnetter, D. (Dusan), Grajda, A. (Aneta), Gregor, R. D. (Ronald D.), Grodzicki, T. (Tomasz), Grontved, A. (Anders), Gruden, G. (Grabriella), Grujic, V. (Vera), Guan, O. P. (Ong Peng), Gudnason, V. (Vilmundur), Guerrero, R. (Ramiro), Guessous, I. (Idris), Guimaraes, A. L. (Andre L.), Gulliford, M. C. (Martin C.), Gunnlaugsdottir, J. (Johanna), Gunter, M. (Marc), Gupta, P. C. (Prakash C.), Gureje, O. (Oye), Gurzkowska, B. (Beata), Gutierrez, L. (Laura), Gutzwiller, F. (Felix), Hadaegh, F. (Farzad), Halkjaer, J. (Jytte), Hambleton, I. R. (Ian R.), Hardy, R. (Rebecca), Harikumar, R. (Rachakulla), Hata, J. (Jun), Hayes, A. J. (Alison J.), He, J. (Jiang), Hendriks, M. E. (Marleen Elisabeth), Henriques, A. (Ana), Hernandez Cadena, L. (Leticia), . (), Herrala, S. (Sauli), Heshmat, R. (Ramin), Hihtaniemi, I. T. (Ilpo Tapani), Ho, S. Y. (Sai Yin), Ho, S. C. (Suzanne C.), Hobbs, M. (Michael), Hofman, A. (Albert), Dinc, G. H. (Gonul Horasan), Hormiga, C. M. (Claudia M.), Horta, B. L. (Bernardo L.), Houti, L. (Leila), Howitt, C. (Christina), Htay, T. T. (Thein Thein), Htet, A. S. (Aung Soe), Hu, Y. (Yonghua), Maria Huerta, J. (Jose), Husseini, A. S. (Abdullatif S.), Huybrechts, I. (Inge), Hwalla, N. (Nahla), Iacoviello, L. (Licia), Iannone, A. G. (Anna G.), Ibrahim, M. M. (M. Mohsen), Ikram, M. A. (M. Arfan), Irazola, V. E. (Vilma E.), Islam, M. (Muhammad), Ivkovic, V. (Vanja), Iwasaki, M. (Masanori), Jacobs, J. M. (Jeremy M.), Jafar, T. (Tazeen), Jamrozik, K. (Konrad), Janszky, I. (Imre), Jasienska, G. (Grazyna), Jelakovic, B. (Bojan), Jiang, C. Q. (Chao Qiang), Johansson, M. (Mattias), Jonas, J. B. (Jost B.), Jorgensen, T. (Torben), Joshi, P. (Pradeep), Juolevi, A. (Anne), Jurak, G. (Gregor), Juresa, V. (Vesna), Kaaks, R. (Rudolf), Kafatos, A. (Anthony), Kalter-Leibovici, O. (Ofra), Kamaruddin, N. A. (Nor Azmi), Kasaeian, A. (Amir), Katz, J. (Joanne), Kauhanen, J. (Jussi), Kaur, P. (Prabhdeep), Kavousi, M. (Maryam), Kazakbaeva, G. (Gyulli), Keil, U. (Ulrich), Boker, L. K. (Lital Keinan), Keinanen-Kiukaanniemi, S. (Sirkka), Kelishadi, R. (Roya), Kemper, H. C. (Han C. G.), Kersting, M. (Mathilde), Key, T. (Timothy), Khader, Y. S. (Yousef Saleh), Khalili, D. (Davood), Khang, Y.-H. (Young-Ho), Khaw, K.-T. (Kay-Tee), Kiechl, S. (Stefan), Killewo, J. (Japhet), Kim, J. (Jeongseon), Klumbiene, J. (Jurate), Kolle, E. (Elin), Kolsteren, P. (Patrick), Korrovits, P. (Paul), Koskinen, S. (Seppo), Kouda, K. (Katsuyasu), Koziel, S. (Slawomir), Kristensen, P. L. (Peter Lund), Krokstad, S. (Steinar), Kromhout, D. (Daan), Kruger, H. S. (Herculina S.), Kubinova, R. (Ruzena), Kuciene, R. (Renata), Kuh, D. (Diana), Kujala, U. M. (Urho M.), Kula, K. (Krzysztof), Kulaga, Z. (Zbigniew), Kumar, R. K. (R. Krishna), Kurjata, P. (Pawel), Kusuma, Y. S. (Yadlapalli S.), Kuulasmaa, K. (Kari), Kyobutungi, C. (Catherine), Lachat, C. (Carl), Landrove, O. (Orlando), Lanska, V. (Vera), Lappas, G. (Georg), Larijani, B. (Bagher), Laugsand, L. E. (Lars E.), Le, T. D. (Tuyen D.), Leclercq, C. (Catherine), Lee, J. (Jeannette), Lee, J. (Jeonghee), Lehtimaki, T. (Terho), Lekhraj, R. (Rampal), Leon-Munoz, L. M. (Luz M.), Levitt, N. S. (Naomi S.), Li, Y. (Yanping), Lilly, C. L. (Christa L.), Lim, W.-Y. (Wei-Yen), Fernanda Lima-Costa, M. (M.), Lin, H.-H. (Hsien-Ho), Lin, X. (Xu), Linneberg, A. (Allan), Lissner, L. (Lauren), Litwin, M. (Mieczyslaw), Lorbeer, R. (Roberto), Lotufo, P. A. (Paulo A.), Eugenio Lozano, J. (Jose), Luksiene, D. (Dalia), Lundqvist, A. (Annamari), Lunet, N. (Nuno), Lytsy, P. (Per), Ma, G. (Guansheng), Ma, J. (Jun), Machado-Coelho, G. L. (George L. L.), Machi, S. (Suka), Maggi, S. (Stefania), Magliano, D. J. (Dianna J.), Majer, M. (Marjeta), Makdisse, M. (Marcia), Malekzadeh, R. (Reza), Malhotra, R. (Rahul), Rao, K. M. (Kodavanti Mallikharjuna), Malyutina, S. (Sofia), Manios, Y. (Yannis), Mann, J. I. (Jim I.), Manzato, E. (Enzo), Margozzini, P. (Paula), Marques-Vidal, P. (Pedro), Marrugat, J. (Jaume), Martorell, R. (Reynaldo), Mathiesen, E. B. (Ellisiv B.), Matijasevich, A. (Alicia), Matsha, T. E. (Tandi E.), Mbanya, J. C. (Jean Claude N.), Posso, A. J. (Anselmo J. Mc Donald), McFarlane, S. R. (Shelly R.), McGarvey, S. T. (Stephen T.), McLachlan, S. (Stela), McLean, R. M. (Rachael M.), McNulty, B. A. (Breige A.), Khir, A. S. (Amir Sharifuddin Md), Mediene-Benchekor, S. (Sounnia), Medzioniene, J. (Jurate), Meirhaeghe, A. (Aline), Meisinger, C. (Christa), Menezes, A. M. (Ana Maria B.), Menon, G. R. (Geetha R.), Meshram, I. I. (Indrapal I.), Metspalu, A. (Andres), Mi, J. (Jie), Mikkel, K. (Kairit), Miller, J. C. (Jody C.), Francisco Miquel, J. (Juan), Jaime Miranda, J. (J.), Misigoj-Durakovic, M. (Marjeta), Mohamed, M. K. (Mostafa K.), Mohammad, K. (Kazem), Mohammadifard, N. (Noushin), Mohan, V. (Viswanathan), Yusoff, M. F. (Muhammad Fadhli Mohd), Moller, N. C. (Niels C.), Molnar, D. (Denes), Momenan, A. (Amirabbas), Monyeki, K. D. (Kotsedi Daniel K.), Moreira, L. B. (Leila B.), Morejon, A. (Alain), Moreno, L. A. (Luis A.), Morgan, K. (Karen), Moschonis, G. (George), Mossakowska, M. (Malgorzata), Mostafa, A. (Aya), Mota, J. (Jorge), Motlagh, M. E. (Mohammad Esmaeel), Motta, J. (Jorge), Muiesan, M. L. (Maria L.), Mueller-Nurasyid, M. (Martina), Murphy, N. (Neil), Mursu, J. (Jaakko), Musil, V. (Vera), Nagel, G. (Gabriele), Naidu, B. M. (Balkish M.), Nakamura, H. (Harunobu), Namsna, J. (Jana), Nang, E. E. (Ei Ei K.), Nangia, V. B. (Vinay B.), Narake, S. (Sameer), Maria Navarrete-Munoz, E. (Eva), Ndiaye, N. C. (Ndeye Coumba), Neal, W. A. (William A.), Nenko, I. (Ilona), Nervi, F. (Flavio), Nguyen, N. D. (Nguyen D.), Nieto-Martinez, R. E. (Ramfis E.), Niiranen, T. J. (Teemu J.), Ning, G. (Guang), Ninomiya, T. (Toshiharu), Nishtar, S. (Sania), Noale, M. (Marianna), Noboa, O. A. (Oscar A.), Noorbala, A. A. (Ahmad Ali), Norat, T. (Teresa), Noto, D. (Davide), Al Nsour, M. (Mohannad), O'Reilly, D. (Dermot), Oh, K. (Kyungwon), Olinto, M. T. (Maria Teresa A.), Oliveira, I. O. (Isabel O.), Omar, M. A. (Mohd Azahadi), Onat, A. (Altan), Ordunez, P. (Pedro), Osmond, C. (Clive), Ostojic, S. M. (Sergej M.), Otero, J. A. (Johanna A.), Overvad, K. (Kim), Owusu-Dabo, E. (Ellis), Paccaud, F. M. (Fred Michel), Padez, C. (Cristina), Pahomova, E. (Elena), Pajak, A. (Andrzej), Palli, D. (Domenico), Palmieri, L. (Luigi), Panda-Jonas, S. (Songhomitra), Panza, F. (Francesco), Papandreou, D. (Dimitrios), Parnell, W. R. (Winsome R.), Parsaeian, M. (Mahboubeh), Pecin, I. (Ivan), Pednekar, M. S. (Mangesh S.), Peer, N. (Nasheeta), Peeters, P. H. (Petra H.), Peixoto, S. V. (Sergio Viana), Pelletier, C. (Catherine), Peltonen, M. (Markku), Pereira, A. C. (Alexandre C.), Marina Perez, R. (Rosa), Peters, A. (Annette), Petkeviciene, J. (Janina), Pigeot, I. (Iris), Pikhart, H. (Hynek), Pilav, A. (Aida), Pilotto, L. (Lorenza), Pitakaka, F. (Freda), Plans-Rubio, P. (Pedro), Polakowska, M. (Maria), Polasek, O. (Ozren), Porta, M. (Miquel), Portegies, M. L. (Marileen L. P.), Pourshams, A. (Akram), Pradeepa, R. (Rajendra), Prashant, M. (Mathur), Price, J. F. (Jacqueline F.), Puiu, M. (Maria), Punab, M. (Margus), Qasrawi, R. F. (Radwan F.), Qorbani, M. (Mostafa), Radic, I. (Ivana), Radisauskas, R. (Ricardas), Rahman, M. (Mahfuzar), Raitakari, O. (Olli), Raj, M. (Manu), Rao, S. R. (Sudha Ramachandra), Ramos, E. (Elisabete), Rampal, S. (Sanjay), Rangel Reina, D. A. (Daniel A.), Rasmussen, F. (Finn), Redon, J. (Josep), Reganit, P. F. (Paul Ferdinand M.), Ribeiro, R. (Robespierre), Riboli, E. (Elio), Rigo, F. (Fernando), de Wit, T. F. (Tobias F. Rinke), Ritti-Dias, R. M. (Raphael M.), Robinson, S. M. (Sian M.), Robitaille, C. (Cynthia), Rodriguez-Artalejo, F. (Fernando), Rodriguez-Villamizar, L. A. (Laura A.), Rojas-Martinez, R. (Rosalba), Rosengren, A. (Annika), Rubinstein, A. (Adolfo), Rui, O. (Ornelas), Sandra Ruiz-Betancourt, B. (Blanca), Russo Horimoto, A. R. (Andrea R. V.), Rutkowski, M. (Marcin), Sabanayagam, C. (Charumathi), Sachdev, H. S. (Harshpal S.), Saidi, O. (Olfa), Sakarya, S. (Sibel), Salanave, B. (Benoit), Salazar Martinez, E. (Eduardo), Salmeron, D. (Diego), Salomaa, V. (Veikko), Salonen, J. T. (Jukka T.), Salvetti, M. (Massimo), Sanchez-Abanto, J. (Jose), Sans, S. (Susana), Santos, D. (Diana), Santos, I. S. (Ina S.), dos Santos, R. N. (Renata Nunes), Santos, R. (Rute), Saramies, J. L. (Jouko L.), Sardinha, L. B. (Luis B.), Margolis, G. S. (Giselle Sarganas), Sarrafzadegan, N. (Nizal), Saum, K.-U. (Kai-Uwe), Savva, S. C. (Savvas C.), Scazufca, M. (Marcia), Schargrodsky, H. (Herman), Schneider, I. J. (Ione J.), Schultsz, C. (Constance), Schutte, A. E. (Aletta E.), Sen, A. (Abhijit), Senbanjo, I. O. (Idowu O.), Sepanlou, S. G. (Sadaf G.), Sharma, S. K. (Sanjib K.), Shaw, J. E. (Jonathan E.), Shibuya, K. (Kenji), Shin, D. W. (Dong Wook), Shin, Y. (Youchan), Siantar, R. (Rosalynn), Sibai, A. M. (Abla M.), Santos Silva, D. A. (Diego Augusto), Simon, M. (Mary), Simons, J. (Judith), Simons, L. A. (Leon A.), Sjotrom, M. (Michael), Skovbjerg, S. (Sine), Slowikowska-Hilczer, J. (Jolanta), Slusarczyk, P. (Przemyslaw), Smith, M. C. (Margaret C.), Snijder, M. B. (Marieke B.), So, H.-K. (Hung-Kwan), Sobngwi, E. (Eugene), Soderberg, S. (Stefan), Solfrizzi, V. (Vincenzo), Sonestedt, E. (Emily), Song, Y. (Yi), Sorensen, T. I. (Thorkild I. A.), Jerome, C. S. (Charles Sossa), Soumare, A. (Aicha), Staessen, J. A. (Jan A.), Starc, G. (Gregor), Stathopoulou, M. G. (Maria G.), Stavreski, B. (Bill), Steene-Johannessen, J. (Jostein), Stehle, P. (Peter), Stein, A. D. (Aryeh D.), Stergiou, G. S. (George S.), Stessman, J. (Jochanan), Stieber, J. (Jutta), Stoeckl, D. (Doris), Stocks, T. (Tanja), Stokwiszewski, J. (Jakub), Stronks, K. (Karien), Strufaldi, M. W. (Maria Wany), Sun, C.-A. (Chien-An), Sung, Y.-T. (Yn-Tz), Suriyawongpaisal, P. (Paibul), Sy, R. G. (Rody G.), Tai, E. S. (E. Shyong), Tammesoo, M.-L. (Mari-Liis), Tamosiunas, A. (Abdonas), Tang, L. (Line), Tang, X. (Xun), Tanser, F. (Frank), Tao, Y. (Yong), Tarawneh, M. R. (Mohammed Rasoul), Tarqui-Mamani, C. B. (Carolina B.), Taylor, A. (Anne), Theobald, H. (Holger), Thijs, L. (Lutgarde), Thuesen, B. H. (Betina H.), Tjonneland, A. (Anne), Tolonen, H. K. (Hanna K.), Topbas, M. (Murat), Topor-Madry, R. (Roman), Jose Tormo, M. (Maria), Torrent, M. (Maties), Traissac, P. (Pierre), Trichopoulos, D. (Dimitrios), Trichopoulou, A. (Antonia), Trinh, O. T. (Oanh T. H.), Trivedi, A. (Atul), Tshepo, L. (Lechaba), Tulloch-Reid, M. K. (Marshall K.), Tuomainen, T.-P. (Tomi-Pekka), Turley, M. L. (Maria L.), Tynelius, P. (Per), Tzourio, C. (Christophe), Ueda, P. (Peter), Ugel, E. (Eunice), Ulmer, H. (Hanno), Uusitalo, H. M. (Hannu M. T.), Valdivia, G. (Gonzalo), Valvi, D. (Damaskini), van der Schouw, Y. T. (Yvonne T.), Van Herck, K. (Koen), van Rossem, L. (Lenie), van Valkengoed, I. G. (Irene G. M.), Vanderschueren, D. (Dirk), Vanuzzo, D. (Diego), Vatten, L. (Lars), Vega, T. (Tomas), Velasquez-Melendez, G. (Gustavo), Veronesi, G. (Giovanni), Verschuren, W. M. (W. M. Monique), Verstraeten, R. (Roosmarijn), Victora, C. G. (Cesar G.), Viet, L. (Lucie), Viikari-Juntura, E. (Eira), Vineis, P. (Paolo), Vioque, J. (Jesus), Virtanen, J. K. (Jyrki K.), Visvikis-Siest, S. (Sophie), Viswanathan, B. (Bharathi), Vollenweider, P. (Peter), Vrdoljak, A. (Ana), Vrijheid, M. (Martine), Wade, A. N. (Alisha N.), Wagner, A. (Aline), Walton, J. (Janette), Mohamud, W. N. (Wan Nazaimoon Wan), Wang, M.-D. (Ming-Dong), Wang, Q. (Qian), Wang, Y. X. (Ya Xing), Wannamethee, S. G. (S. Goya), Wareham, N. (Nicholas), Wederkopp, N. (Niels), Weerasekera, D. (Deepa), Whincup, P. H. (Peter H.), Widhalm, K. (Kurt), Widyahening, I. S. (Indah S.), Wiecek, A. (Andrzej), Wijga, A. H. (Alet H.), Wilks, R. J. (Rainford J.), Willeit, P. (Peter), Williams, E. A. (Emmanuel A.), Wilsgaard, T. (Tom), Wojtyniak, B. (Bogdan), Wong, T. Y. (Tien Yin), Wong-McClure, R. A. (Roy A.), Woo, J. (Jean), Wu, A. G. (Aleksander Giwercman), Wu, F. C. (Frederick C.), Wu, S. L. (Shou Ling), Xu, H. (Haiquan), Yan, W. (Weili), Yang, X. (Xiaoguang), Ye, X. (Xingwang), Yiallouros, P. K. (Panayiotis K.), Yoshihara, A. (Akihiro), Younger-Coleman, N. O. (Novie O.), Yusoff, A. F. (Ahmad F.), Zambon, S. (Sabina), Zdrojewski, T. (Tomasz), Zeng, Y. (Yi), Zhao, D. (Dong), Zhao, W. (Wenhua), Zheng, Y. (Yingffeng), Zhu, D. (Dan), Zimmermann, E. (Esther), Zuniga Cisneros, J. (Julio), Zhou, B. (Bin), Bentham, J. (James), Di Cesare, M. (Mariachiara), Bixby, H. (Honor), Danaei, G. (Goodarz), Cowan, M. J. (Melanie J.), Paciorek, C. J. (Christopher J.), Singh, G. (Gitanjali), Hajifathalian, K. (Kaveh), Bennett, J. E. (James E.), Taddei, C. (Cristina), Bilano, V. (Ver), Carrillo-Larco, R. M. (Rodrigo M.), Djalalinia, S. (Shirin), Khatibzadeh, S. (Shahab), Lugero, C. (Charles), Peykari, N. (Niloofar), Zhang, W. Z. (Wan Zhu), Lu, Y. (Yuan), Stevens, G. A. (Gretchen A.), Riley, L. M. (Leanne M.), Bovet, P. (Pascal), Elliott, P. (Paul), Gu, D. (Dongfeng), Ikeda, N. (Nayu), Jackson, R. T. (Rod T.), Joffres, M. (Michel), Kengne, A. P. (Andre Pascal), Laatikainen, T. (Tiina), Lam, T. H. (Tai Hing), Laxmaiah, A. (Avula), Liu, J. (Jing), Miranda, J. J. (J. Jaime), Mondo, C. K. (Charles K.), Neuhauser, H. K. (Hannelore K.), Sundstrom, J. (Johan), Smeeth, L. (Liam), Soric, M. (Maroje), Woodward, M. (Mark), Ezzati, M. (Majid), Abarca-Gomez, L. (Leandra), Abdeen, Z. A. (Ziad A.), Rahim, H. A. (Hanan Abdul), Abu-Rmeileh, N. M. (Niveen M.), Acosta-Cazares, B. (Benjamin), Adams, R. (Robert), Aekplakorn, W. (Wichai), Afsana, K. (Kaosar), Aguilar-Salinas, C. A. (Carlos A.), Agyemang, C. (Charles), Ahmadvand, A. (Alireza), Ahrens, W. (Wolfgang), Al Raddadi, R. (Rajaa), Al Woyatan, R. (Rihab), Ali, M. M. (Mohamed M.), Alkerwi, A. (Ala'a), Aly, E. (Eman), Amouyel, P. (Philippe), Amuzu, A. (Antoinette), Andersen, L. B. (Lars Bo), Anderssen, S. A. (Sigmund A.), Angquist, L. (Lars), Anjana, R. M. (Ranjit Mohan), Ansong, D. (Daniel), Aounallah-Skhiri, H. (Hajer), Araujo, J. (Joana), Ariansen, I. (Inger), Aris, T. (Tahir), Arlappa, N. (Nimmathota), Aryal, K. (Krishna), Arveiler, D. (Dominique), Assah, F. K. (Felix K.), Assuncao, M. C. (Maria Cecilia F.), Avdicova, M. (Maria), Azevedo, A. (Ana), Azizi, F. (Fereidoun), Babu, B. V. (Bontha V.), Bahijri, S. (Suhad), Balakrishna, N. (Nagalla), Bandosz, P. (Piotr), Banegas, J. R. (Jose R.), Barbagallo, C. M. (Carlo M.), Barcelo, A. (Alberto), Barkat, A. (Amina), Barros, A. J. (Aluisio J. D.), Barros, M. V. (Mauro V.), Bata, I. (Iqbal), Batieha, A. M. (Anwar M.), Baur, L. A. (Louise A.), Beaglehole, R. (Robert), Ben Romdhane, H. (Habiba), Benet, M. (Mikhail), Benson, L. S. (Lowell S.), Bernabe-Ortiz, A. (Antonio), Bernotiene, G. (Gailute), Bettiol, H. (Heloisa), Bhagyalaxmi, A. (Aroor), Bharadwaj, S. (Sumit), Bhargava, S. K. (Santosh K.), Bi, Y. (Yufang), Bikbov, M. (Mukharram), Bjerregaard, P. (Peter), Bjertness, E. (Espen), Bjokelund, C. (Cecilia), Blokstra, A. (Anneke), Bo, S. (Simona), Bobak, M. (Martin), Boeing, H. (Heiner), Boggia, J. G. (Jose G.), Boissonnet, C. P. (Carlos P.), Bongard, V. (Vanina), Braeckman, L. (Lutgart), Brajkovich, I. (Imperia), Branca, F. (Francesco), Breckenkamp, J. (Juergen), Brenner, H. (Hermann), Brewster, L. M. (Lizzy M.), Bruno, G. (Graziella), Bueno-de-Mesquita, H. B. (H. B. (as)), Bugge, A. (Anna), Burns, C. (Con), Bursztyn, M. (Michael), de Leon, A. C. (Antonio Cabrera), Cameron, C. (Christine), Can, G. (Gunay), Candido, A. P. (Ana Paula C.), Capuano, V. (Vincenzo), Cardoso, V. C. (Viviane C.), Carlsson, A. C. (Axel C.), Carvalho, M. J. (Maria J.), Casanueva, F. F. (Felipe F.), Casas, J.-P. (Juan-Pablo), Caserta, C. A. (Carmelo A.), Chamukuttan, S. (Snehalatha), Chan, A. W. (Angelique W.), Chan, Q. (Queenie), Chaturvedi, H. K. (Himanshu K.), Chaturvedi, N. (Nishi), Chen, C.-J. (Chien-Jen), Chen, F. (Fangfang), Chen, H. (Huashuai), Chen, S. (Shuohua), Chen, Z. (Zhengming), Cheng, C.-Y. (Ching-Yu), Dekkaki, I. C. (Imane Cherkaoui), Chetrit, A. (Angela), Chiolero, A. (Arnaud), Chiou, S.-T. (Shu-Ti), Chirita-Emandi, A. (Adela), Cho, B. (Belong), Cho, Y. (Yumi), Chudek, J. (Jerzy), Cifkova, R. (Renata), Claessens, F. (Frank), Clays, E. (Els), Concin, H. (Hans), Cooper, C. (Cyrus), Cooper, R. (Rachel), Coppinger, T. C. (Tara C.), Costanzo, S. (Simona), Cottel, D. (Dominique), Cowell, C. (Chris), Craig, C. L. (Cora L.), Crujeiras, A. B. (Ana B.), Cruz, J. J. (Juan J.), D'Arrigo, G. (Graziella), d'Orsi, E. (Eleonora), Dallongeville, J. (Jean), Damasceno, A. (Albertino), Dankner, R. (Rachel), Dantoft, T. M. (Thomas M.), Dauchet, L. (Luc), De Backer, G. (Guy), de Gaetano, G. (Giovanni), De Henauw, S. (Stefaan), De Smedt, D. (Delphine), Deepa, M. (Mohan), Dehghan, A. (Abbas), Delisle, H. (Helene), Deschamps, V. (Valerie), Dhana, K. (Klodian), Di Castelnuovo, A. F. (Augusto F.), Dias-da-Costa, J. S. (Juvenal Soares), Diaz, A. (Alejandro), Dickerson, T. T. (Ty T.), Do, H. T. (Ha T. P.), Dobson, A. J. (Annette J.), Donfrancesco, C. (Chiara), Donoso, S. P. (Silvana P.), Doering, A. (Angela), Doua, K. (Kouamelan), Drygas, W. (Wojciech), Dulskiene, V. (Virginija), Dzakula, A. (Aleksandar), Dzerve, V. (Vilnis), Dziankowska-Zaborszczyk, E. (Elzbieta), Eggertsen, R. (Robert), Ekelund, U. (Ulf), El Ati, J. (Jalila), Ellert, U. (Ute), Elosua, R. (Roberto), Erasmus, R. T. (Rajiv T.), Erem, C. (Cihangir), Eriksen, L. (Louise), Escobedo-de la Pena, J. (Jorge), Evans, A. (Alun), Faeh, D. (David), Fall, C. H. (Caroline H.), Farzadfar, F. (Farshad), Felix-Redondo, F. J. (Francisco J.), Ferguson, T. S. (Trevor S.), Fernandez-Berges, D. (Daniel), Ferrante, D. (Daniel), Ferrari, M. (Marika), Ferreccio, C. (Catterina), Ferrieres, J. (Jean), Finn, J. D. (Joseph D.), Fischer, K. (Krista), Foeger, B. (Bernhard), Foo, L. H. (Leng Huat), Forslund, A.-S. (Ann-Sofie), Forsner, M. (Maria), Fortmann, S. P. (Stephen P.), Fouad, H. M. (Heba M.), Francis, D. K. (Damian K.), Franco, M. d. (Maria do Carmo), Franco, O. H. (Oscar H.), Frontera, G. (Guillermo), Fuchs, F. D. (Flavio D.), Fuchs, S. C. (Sandra C.), Fujita, Y. (Yuki), Furusawa, T. (Takuro), Gaciong, Z. (Zbigniew), Gareta, D. (Dickman), Garnett, S. P. (Sarah P.), Gaspoz, J.-M. (Jean-Michel), Gasull, M. (Magda), Gates, L. (Louise), Gavrila, D. (Diana), Geleijnse, J. M. (Johanna M.), Ghasemian, A. (Anoosheh), Ghimire, A. (Anup), Giampaoli, S. (Simona), Gianfagna, F. (Francesco), Giovannelli, J. (Jonathan), Goldsmith, R. A. (Rebecca A.), Goncalves, H. (Helen), Gonzalez Gross, M. (Marcela), Gonzalez Rivas, J. P. (Juan P.), Gottrand, F. (Frederic), Graff-Iversen, S. (Sidsel), Grafnetter, D. (Dusan), Grajda, A. (Aneta), Gregor, R. D. (Ronald D.), Grodzicki, T. (Tomasz), Grontved, A. (Anders), Gruden, G. (Grabriella), Grujic, V. (Vera), Guan, O. P. (Ong Peng), Gudnason, V. (Vilmundur), Guerrero, R. (Ramiro), Guessous, I. (Idris), Guimaraes, A. L. (Andre L.), Gulliford, M. C. (Martin C.), Gunnlaugsdottir, J. (Johanna), Gunter, M. (Marc), Gupta, P. C. (Prakash C.), Gureje, O. (Oye), Gurzkowska, B. (Beata), Gutierrez, L. (Laura), Gutzwiller, F. (Felix), Hadaegh, F. (Farzad), Halkjaer, J. (Jytte), Hambleton, I. R. (Ian R.), Hardy, R. (Rebecca), Harikumar, R. (Rachakulla), Hata, J. (Jun), Hayes, A. J. (Alison J.), He, J. (Jiang), Hendriks, M. E. (Marleen Elisabeth), Henriques, A. (Ana), Hernandez Cadena, L. (Leticia), . (), Herrala, S. (Sauli), Heshmat, R. (Ramin), Hihtaniemi, I. T. (Ilpo Tapani), Ho, S. Y. (Sai Yin), Ho, S. C. (Suzanne C.), Hobbs, M. (Michael), Hofman, A. (Albert), Dinc, G. H. (Gonul Horasan), Hormiga, C. M. (Claudia M.), Horta, B. L. (Bernardo L.), Houti, L. (Leila), Howitt, C. (Christina), Htay, T. T. (Thein Thein), Htet, A. S. (Aung Soe), Hu, Y. (Yonghua), Maria Huerta, J. (Jose), Husseini, A. S. (Abdullatif S.), Huybrechts, I. (Inge), Hwalla, N. (Nahla), Iacoviello, L. (Licia), Iannone, A. G. (Anna G.), Ibrahim, M. M. (M. Mohsen), Ikram, M. A. (M. Arfan), Irazola, V. E. (Vilma E.), Islam, M. (Muhammad), Ivkovic, V. (Vanja), Iwasaki, M. (Masanori), Jacobs, J. M. (Jeremy M.), Jafar, T. (Tazeen), Jamrozik, K. (Konrad), Janszky, I. (Imre), Jasienska, G. (Grazyna), Jelakovic, B. (Bojan), Jiang, C. Q. (Chao Qiang), Johansson, M. (Mattias), Jonas, J. B. (Jost B.), Jorgensen, T. (Torben), Joshi, P. (Pradeep), Juolevi, A. (Anne), Jurak, G. (Gregor), Juresa, V. (Vesna), Kaaks, R. (Rudolf), Kafatos, A. (Anthony), Kalter-Leibovici, O. (Ofra), Kamaruddin, N. A. (Nor Azmi), Kasaeian, A. (Amir), Katz, J. (Joanne), Kauhanen, J. (Jussi), Kaur, P. (Prabhdeep), Kavousi, M. (Maryam), Kazakbaeva, G. (Gyulli), Keil, U. (Ulrich), Boker, L. K. (Lital Keinan), Keinanen-Kiukaanniemi, S. (Sirkka), Kelishadi, R. (Roya), Kemper, H. C. (Han C. G.), Kersting, M. (Mathilde), Key, T. (Timothy), Khader, Y. S. (Yousef Saleh), Khalili, D. (Davood), Khang, Y.-H. (Young-Ho), Khaw, K.-T. (Kay-Tee), Kiechl, S. (Stefan), Killewo, J. (Japhet), Kim, J. (Jeongseon), Klumbiene, J. (Jurate), Kolle, E. (Elin), Kolsteren, P. (Patrick), Korrovits, P. (Paul), Koskinen, S. (Seppo), Kouda, K. (Katsuyasu), Koziel, S. (Slawomir), Kristensen, P. L. (Peter Lund), Krokstad, S. (Steinar), Kromhout, D. (Daan), Kruger, H. S. (Herculina S.), Kubinova, R. (Ruzena), Kuciene, R. (Renata), Kuh, D. (Diana), Kujala, U. M. (Urho M.), Kula, K. (Krzysztof), Kulaga, Z. (Zbigniew), Kumar, R. K. (R. Krishna), Kurjata, P. (Pawel), Kusuma, Y. S. (Yadlapalli S.), Kuulasmaa, K. (Kari), Kyobutungi, C. (Catherine), Lachat, C. (Carl), Landrove, O. (Orlando), Lanska, V. (Vera), Lappas, G. (Georg), Larijani, B. (Bagher), Laugsand, L. E. (Lars E.), Le, T. D. (Tuyen D.), Leclercq, C. (Catherine), Lee, J. (Jeannette), Lee, J. (Jeonghee), Lehtimaki, T. (Terho), Lekhraj, R. (Rampal), Leon-Munoz, L. M. (Luz M.), Levitt, N. S. (Naomi S.), Li, Y. (Yanping), Lilly, C. L. (Christa L.), Lim, W.-Y. (Wei-Yen), Fernanda Lima-Costa, M. (M.), Lin, H.-H. (Hsien-Ho), Lin, X. (Xu), Linneberg, A. (Allan), Lissner, L. (Lauren), Litwin, M. (Mieczyslaw), Lorbeer, R. (Roberto), Lotufo, P. A. (Paulo A.), Eugenio Lozano, J. (Jose), Luksiene, D. (Dalia), Lundqvist, A. (Annamari), Lunet, N. (Nuno), Lytsy, P. (Per), Ma, G. (Guansheng), Ma, J. (Jun), Machado-Coelho, G. L. (George L. L.), Machi, S. (Suka), Maggi, S. (Stefania), Magliano, D. J. (Dianna J.), Majer, M. (Marjeta), Makdisse, M. (Marcia), Malekzadeh, R. (Reza), Malhotra, R. (Rahul), Rao, K. M. (Kodavanti Mallikharjuna), Malyutina, S. (Sofia), Manios, Y. (Yannis), Mann, J. I. (Jim I.), Manzato, E. (Enzo), Margozzini, P. (Paula), Marques-Vidal, P. (Pedro), Marrugat, J. (Jaume), Martorell, R. (Reynaldo), Mathiesen, E. B. (Ellisiv B.), Matijasevich, A. (Alicia), Matsha, T. E. (Tandi E.), Mbanya, J. C. (Jean Claude N.), Posso, A. J. (Anselmo J. Mc Donald), McFarlane, S. R. (Shelly R.), McGarvey, S. T. (Stephen T.), McLachlan, S. (Stela), McLean, R. M. (Rachael M.), McNulty, B. A. (Breige A.), Khir, A. S. (Amir Sharifuddin Md), Mediene-Benchekor, S. (Sounnia), Medzioniene, J. (Jurate), Meirhaeghe, A. (Aline), Meisinger, C. (Christa), Menezes, A. M. (Ana Maria B.), Menon, G. R. (Geetha R.), Meshram, I. I. (Indrapal I.), Metspalu, A. (Andres), Mi, J. (Jie), Mikkel, K. (Kairit), Miller, J. C. (Jody C.), Francisco Miquel, J. (Juan), Jaime Miranda, J. (J.), Misigoj-Durakovic, M. (Marjeta), Mohamed, M. K. (Mostafa K.), Mohammad, K. (Kazem), Mohammadifard, N. (Noushin), Mohan, V. (Viswanathan), Yusoff, M. F. (Muhammad Fadhli Mohd), Moller, N. C. (Niels C.), Molnar, D. (Denes), Momenan, A. (Amirabbas), Monyeki, K. D. (Kotsedi Daniel K.), Moreira, L. B. (Leila B.), Morejon, A. (Alain), Moreno, L. A. (Luis A.), Morgan, K. (Karen), Moschonis, G. (George), Mossakowska, M. (Malgorzata), Mostafa, A. (Aya), Mota, J. (Jorge), Motlagh, M. E. (Mohammad Esmaeel), Motta, J. (Jorge), Muiesan, M. L. (Maria L.), Mueller-Nurasyid, M. (Martina), Murphy, N. (Neil), Mursu, J. (Jaakko), Musil, V. (Vera), Nagel, G. (Gabriele), Naidu, B. M. (Balkish M.), Nakamura, H. (Harunobu), Namsna, J. (Jana), Nang, E. E. (Ei Ei K.), Nangia, V. B. (Vinay B.), Narake, S. (Sameer), Maria Navarrete-Munoz, E. (Eva), Ndiaye, N. C. (Ndeye Coumba), Neal, W. A. (William A.), Nenko, I. (Ilona), Nervi, F. (Flavio), Nguyen, N. D. (Nguyen D.), Nieto-Martinez, R. E. (Ramfis E.), Niiranen, T. J. (Teemu J.), Ning, G. (Guang), Ninomiya, T. (Toshiharu), Nishtar, S. (Sania), Noale, M. (Marianna), Noboa, O. A. (Oscar A.), Noorbala, A. A. (Ahmad Ali), Norat, T. (Teresa), Noto, D. (Davide), Al Nsour, M. (Mohannad), O'Reilly, D. (Dermot), Oh, K. (Kyungwon), Olinto, M. T. (Maria Teresa A.), Oliveira, I. O. (Isabel O.), Omar, M. A. (Mohd Azahadi), Onat, A. (Altan), Ordunez, P. (Pedro), Osmond, C. (Clive), Ostojic, S. M. (Sergej M.), Otero, J. A. (Johanna A.), Overvad, K. (Kim), Owusu-Dabo, E. (Ellis), Paccaud, F. M. (Fred Michel), Padez, C. (Cristina), Pahomova, E. (Elena), Pajak, A. (Andrzej), Palli, D. (Domenico), Palmieri, L. (Luigi), Panda-Jonas, S. (Songhomitra), Panza, F. (Francesco), Papandreou, D. (Dimitrios), Parnell, W. R. (Winsome R.), Parsaeian, M. (Mahboubeh), Pecin, I. (Ivan), Pednekar, M. S. (Mangesh S.), Peer, N. (Nasheeta), Peeters, P. H. (Petra H.), Peixoto, S. V. (Sergio Viana), Pelletier, C. (Catherine), Peltonen, M. (Markku), Pereira, A. C. (Alexandre C.), Marina Perez, R. (Rosa), Peters, A. (Annette), Petkeviciene, J. (Janina), Pigeot, I. (Iris), Pikhart, H. (Hynek), Pilav, A. (Aida), Pilotto, L. (Lorenza), Pitakaka, F. (Freda), Plans-Rubio, P. (Pedro), Polakowska, M. (Maria), Polasek, O. (Ozren), Porta, M. (Miquel), Portegies, M. L. (Marileen L. P.), Pourshams, A. (Akram), Pradeepa, R. (Rajendra), Prashant, M. (Mathur), Price, J. F. (Jacqueline F.), Puiu, M. (Maria), Punab, M. (Margus), Qasrawi, R. F. (Radwan F.), Qorbani, M. (Mostafa), Radic, I. (Ivana), Radisauskas, R. (Ricardas), Rahman, M. (Mahfuzar), Raitakari, O. (Olli), Raj, M. (Manu), Rao, S. R. (Sudha Ramachandra), Ramos, E. (Elisabete), Rampal, S. (Sanjay), Rangel Reina, D. A. (Daniel A.), Rasmussen, F. (Finn), Redon, J. (Josep), Reganit, P. F. (Paul Ferdinand M.), Ribeiro, R. (Robespierre), Riboli, E. (Elio), Rigo, F. (Fernando), de Wit, T. F. (Tobias F. Rinke), Ritti-Dias, R. M. (Raphael M.), Robinson, S. M. (Sian M.), Robitaille, C. (Cynthia), Rodriguez-Artalejo, F. (Fernando), Rodriguez-Villamizar, L. A. (Laura A.), Rojas-Martinez, R. (Rosalba), Rosengren, A. (Annika), Rubinstein, A. (Adolfo), Rui, O. (Ornelas), Sandra Ruiz-Betancourt, B. (Blanca), Russo Horimoto, A. R. (Andrea R. V.), Rutkowski, M. (Marcin), Sabanayagam, C. (Charumathi), Sachdev, H. S. (Harshpal S.), Saidi, O. (Olfa), Sakarya, S. (Sibel), Salanave, B. (Benoit), Salazar Martinez, E. (Eduardo), Salmeron, D. (Diego), Salomaa, V. (Veikko), Salonen, J. T. (Jukka T.), Salvetti, M. (Massimo), Sanchez-Abanto, J. (Jose), Sans, S. (Susana), Santos, D. (Diana), Santos, I. S. (Ina S.), dos Santos, R. N. (Renata Nunes), Santos, R. (Rute), Saramies, J. L. (Jouko L.), Sardinha, L. B. (Luis B.), Margolis, G. S. (Giselle Sarganas), Sarrafzadegan, N. (Nizal), Saum, K.-U. (Kai-Uwe), Savva, S. C. (Savvas C.), Scazufca, M. (Marcia), Schargrodsky, H. (Herman), Schneider, I. J. (Ione J.), Schultsz, C. (Constance), Schutte, A. E. (Aletta E.), Sen, A. (Abhijit), Senbanjo, I. O. (Idowu O.), Sepanlou, S. G. (Sadaf G.), Sharma, S. K. (Sanjib K.), Shaw, J. E. (Jonathan E.), Shibuya, K. (Kenji), Shin, D. W. (Dong Wook), Shin, Y. (Youchan), Siantar, R. (Rosalynn), Sibai, A. M. (Abla M.), Santos Silva, D. A. (Diego Augusto), Simon, M. (Mary), Simons, J. (Judith), Simons, L. A. (Leon A.), Sjotrom, M. (Michael), Skovbjerg, S. (Sine), Slowikowska-Hilczer, J. (Jolanta), Slusarczyk, P. (Przemyslaw), Smith, M. C. (Margaret C.), Snijder, M. B. (Marieke B.), So, H.-K. (Hung-Kwan), Sobngwi, E. (Eugene), Soderberg, S. (Stefan), Solfrizzi, V. (Vincenzo), Sonestedt, E. (Emily), Song, Y. (Yi), Sorensen, T. I. (Thorkild I. A.), Jerome, C. S. (Charles Sossa), Soumare, A. (Aicha), Staessen, J. A. (Jan A.), Starc, G. (Gregor), Stathopoulou, M. G. (Maria G.), Stavreski, B. (Bill), Steene-Johannessen, J. (Jostein), Stehle, P. (Peter), Stein, A. D. (Aryeh D.), Stergiou, G. S. (George S.), Stessman, J. (Jochanan), Stieber, J. (Jutta), Stoeckl, D. (Doris), Stocks, T. (Tanja), Stokwiszewski, J. (Jakub), Stronks, K. (Karien), Strufaldi, M. W. (Maria Wany), Sun, C.-A. (Chien-An), Sung, Y.-T. (Yn-Tz), Suriyawongpaisal, P. (Paibul), Sy, R. G. (Rody G.), Tai, E. S. (E. Shyong), Tammesoo, M.-L. (Mari-Liis), Tamosiunas, A. (Abdonas), Tang, L. (Line), Tang, X. (Xun), Tanser, F. (Frank), Tao, Y. (Yong), Tarawneh, M. R. (Mohammed Rasoul), Tarqui-Mamani, C. B. (Carolina B.), Taylor, A. (Anne), Theobald, H. (Holger), Thijs, L. (Lutgarde), Thuesen, B. H. (Betina H.), Tjonneland, A. (Anne), Tolonen, H. K. (Hanna K.), Topbas, M. (Murat), Topor-Madry, R. (Roman), Jose Tormo, M. (Maria), Torrent, M. (Maties), Traissac, P. (Pierre), Trichopoulos, D. (Dimitrios), Trichopoulou, A. (Antonia), Trinh, O. T. (Oanh T. H.), Trivedi, A. (Atul), Tshepo, L. (Lechaba), Tulloch-Reid, M. K. (Marshall K.), Tuomainen, T.-P. (Tomi-Pekka), Turley, M. L. (Maria L.), Tynelius, P. (Per), Tzourio, C. (Christophe), Ueda, P. (Peter), Ugel, E. (Eunice), Ulmer, H. (Hanno), Uusitalo, H. M. (Hannu M. T.), Valdivia, G. (Gonzalo), Valvi, D. (Damaskini), van der Schouw, Y. T. (Yvonne T.), Van Herck, K. (Koen), van Rossem, L. (Lenie), van Valkengoed, I. G. (Irene G. M.), Vanderschueren, D. (Dirk), Vanuzzo, D. (Diego), Vatten, L. (Lars), Vega, T. (Tomas), Velasquez-Melendez, G. (Gustavo), Veronesi, G. (Giovanni), Verschuren, W. M. (W. M. Monique), Verstraeten, R. (Roosmarijn), Victora, C. G. (Cesar G.), Viet, L. (Lucie), Viikari-Juntura, E. (Eira), Vineis, P. (Paolo), Vioque, J. (Jesus), Virtanen, J. K. (Jyrki K.), Visvikis-Siest, S. (Sophie), Viswanathan, B. (Bharathi), Vollenweider, P. (Peter), Vrdoljak, A. (Ana), Vrijheid, M. (Martine), Wade, A. N. (Alisha N.), Wagner, A. (Aline), Walton, J. (Janette), Mohamud, W. N. (Wan Nazaimoon Wan), Wang, M.-D. (Ming-Dong), Wang, Q. (Qian), Wang, Y. X. (Ya Xing), Wannamethee, S. G. (S. Goya), Wareham, N. (Nicholas), Wederkopp, N. (Niels), Weerasekera, D. (Deepa), Whincup, P. H. (Peter H.), Widhalm, K. (Kurt), Widyahening, I. S. (Indah S.), Wiecek, A. (Andrzej), Wijga, A. H. (Alet H.), Wilks, R. J. (Rainford J.), Willeit, P. (Peter), Williams, E. A. (Emmanuel A.), Wilsgaard, T. (Tom), Wojtyniak, B. (Bogdan), Wong, T. Y. (Tien Yin), Wong-McClure, R. A. (Roy A.), Woo, J. (Jean), Wu, A. G. (Aleksander Giwercman), Wu, F. C. (Frederick C.), Wu, S. L. (Shou Ling), Xu, H. (Haiquan), Yan, W. (Weili), Yang, X. (Xiaoguang), Ye, X. (Xingwang), Yiallouros, P. K. (Panayiotis K.), Yoshihara, A. (Akihiro), Younger-Coleman, N. O. (Novie O.), Yusoff, A. F. (Ahmad F.), Zambon, S. (Sabina), Zdrojewski, T. (Tomasz), Zeng, Y. (Yi), Zhao, D. (Dong), Zhao, W. (Wenhua), Zheng, Y. (Yingffeng), Zhu, D. (Dan), Zimmermann, E. (Esther), and Zuniga Cisneros, J. (Julio)

Abstract

Background: Raised blood pressure is an important risk factor for cardiovascular diseases and chronic kidney disease. We estimated worldwide trends in mean systolic and mean diastolic blood pressure, and the prevalence of, and number of people with, raised blood pressure, defined as systolic blood pressure of 140 mm Hg or higher or diastolic blood pressure of 90 mm Hg or higher. Methods: For this analysis, we pooled national, subnational, or community population-based studies that had measured blood pressure in adults aged 18 years and older. We used a Bayesian hierarchical model to estimate trends from 1975 to 2015 in mean systolic and mean diastolic blood pressure, and the prevalence of raised blood pressure for 200 countries. We calculated the contributions of changes in prevalence versus population growth and ageing to the increase in the number of adults with raised blood pressure. Findings: We pooled 1479 studies that had measured the blood pressures of 19.1 million adults. Global age-standardised mean systolic blood pressure in 2015 was 127.0 mm Hg (95% credible interval 125.7–128.3) in men and 122.3 mm Hg (121.0–123.6) in women; age-standardised mean diastolic blood pressure was 78.7 mm Hg (77.9–79.5) for men and 76.7 mm Hg (75.9–77.6) for women. Global age-standardised prevalence of raised blood pressure was 24.1% (21.4–27.1) in men and 20.1% (17.8–22.5) in women in 2015. Mean systolic and mean diastolic blood pressure decreased substantially from 1975 to 2015 in high-income western and Asia Pacific countries, moving these countries from having some of the highest worldwide blood pressure in 1975 to the lowest in 2015. Mean blood pressure also decreased in women in central and eastern Europe, Latin America and the Caribbean, and, more recently, central Asia, Middle East, and north Africa, but the estimated trends in these super-regions had larger uncertainty than in high-income super-regions. By contrast, mean blood pressure might have increased in

Published
2017

211. STING mediates hepatocyte pyroptosis in liver fibrosis by Epigenetically activating the NLRP3 inflammasome

Author

Yang Xiao, Chong Zhao, Yang Tai, Bei Li, Tian Lan, Enjiang Lai, Wenting Dai, Yangkun Guo, Can Gan, Enis Kostallari, Chengwei Tang, and Jinhang Gao

Subjects
Liver cirrhosis, GSDMD, IRF3, Histone methylation, Oxidative stress, Metabolic reprogramming, Medicine (General), R5-920, Biology (General), QH301-705.5
Abstract

The activation of stimulator of interferon genes (STING) and NOD-like receptor protein 3 (NLRP3) inflammasome-mediated pyroptosis signaling pathways represent two distinct central mechanisms in liver disease. However, the interconnections between these two pathways and the epigenetic regulation of the STING-NLRP3 axis in hepatocyte pyroptosis during liver fibrosis remain unknown. STING and NLRP3 inflammasome signaling pathways are activated in fibrotic livers but are suppressed by Sting knockout. Sting knockout ameliorated hepatic pyroptosis, inflammation, and fibrosis. In vitro, STING induces pyroptosis in primary murine hepatocytes by activating the NLRP3 inflammasome. H3K4-specific histone methyltransferase WD repeat-containing protein 5 (WDR5) and DOT1-like histone H3K79 methyltransferase (DOT1L) are identified to regulate NLRP3 expression in STING-overexpressing AML12 hepatocytes. WDR5/DOT1L-mediated histone methylation enhances interferon regulatory transcription factor 3 (IRF3) binding to the Nlrp3 promoter and promotes STING-induced Nlrp3 transcription in hepatocytes. Moreover, hepatocyte-specific Nlrp3 deletion and downstream Gasdermin D (Gsdmd) knockout attenuate hepatic pyroptosis, inflammation, and fibrosis. RNA-sequencing and metabolomics analysis in murine livers and primary hepatocytes show that oxidative stress and metabolic reprogramming might participate in NLRP3-mediated hepatocyte pyroptosis and liver fibrosis. The STING-NLRP3-GSDMD axis inhibition suppresses hepatic ROS generation. In conclusion, this study describes a novel epigenetic mechanism by which the STING-WDR5/DOT1L/IRF3-NLRP3 signaling pathway enhances hepatocyte pyroptosis and hepatic inflammation in liver fibrosis.

Published
2023
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212. Socialization, Professional Identity Formation and Training for Uncertainty

Author

Stefan Reinsch, Juliane Walther, Stefanie Oess, Wiebke Tschorr, Jonathan Nübel, Jannis Schwanemann, and Can Gero Leineweber

Subjects
Special aspects of education, LC8-6691
Abstract

Clinical knowledge, group facilitation skills, and cognitive congruence are considered important factors for the successful tutoring of Problem Based Learning sessions. In addition, the theory of Community of Practice has become an important tool to approach social learning and knowledge integration in medical education and organizational studies. More research is needed to link these two strands of research. We look at novice medical students’ experiences and comparative reflections on student-tutors and clinician-tutors as facilitators of PBL sessions in a participatory, randomized cross-over design. Qualitative methodologies were used to probe the experiences of participants. In this study, the main factor for successful PBL sessions for first-year students was the creation of a non-hierarchical learning atmosphere, which starkly differentiated itself from the rigidity of a PBL structure organized around clinician-tutors and their hierarchically-imparted knowledge. In contrast, a more flexible strategy of student tutors and their constructive management of “not-knowing” enabled novice students to take steps on their own — of which they were highly appreciative, stressing how it allowed them to develop earlier autonomy with regard to PBL methodology, manage uncertainty, and create a shared identity as a community of learners.

Published
2023
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213. Metabolic rewiring in keratinocytes by miR‐31‐5p identifies therapeutic intervention for psoriasis

Author

Mao‐Jie Wang, Huan‐Jie Huang, Yong‐Yue Xu, Harmjan Vos, Can Gulersonmez, Edwin Stigter, Johan Gerritsen, Marc Pages Gallego, Robert vanEs, Li Li, Hao Deng, Lin Han, Run‐Yue Huang, Chuan‐Jian Lu, and Boudewijn MT Burgering

Subjects
glutaminolysis, metabolism reprogramming, miR‐31, psoriasis, T helper 17 cells, Medicine (General), R5-920, Genetics, QH426-470
Abstract

Abstract Besides genetic alterations, the cellular environment also determines disease onset and progression. When different cell types contribute to disease outcome, this imposes environmental challenges as different cell types likely differ in their extracellular dependencies. Hsa‐microRNA‐31‐5p (miR‐31) is highly expressed in keratinocytes of psoriatic skin, and we show that expression in keratinocytes is induced by limited glucose availability and enables increased survival under limiting glucose conditions by increasing glutamine metabolism. In addition, miR‐31 expression results in not only secretion of specific metabolites (aspartate and glutamate) but also secretion of immunomodulatory factors. We show that this miR‐31‐induced secretory phenotype is sufficient to induce Th17 cell differentiation, a hallmark of psoriasis. Inhibitors of miR31‐induced metabolic rewiring and metabolic crosstalk with immune cells alleviate psoriasis pathology in a mouse model of psoriasis. Together our data illustrate an emerging concept of metabolic interaction across cell compartments that characterizes disease development, which can be employed to design effective treatment options for disease, as shown here for psoriasis.

Published
2023
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216. Glycated hemoglobin measurement and prediction of cardiovascular disease

Author

Emerging Risk Factors Collaboration, Di Angelantonio E, Gao P, Khan H, Butterworth AS, Wormser D, Kaptoge S, Kondapally Seshasai SR, Thompson A, Sarwar N, Willeit P, Ridker PM, Barr EL, Khaw KT, Psaty BM, Brenner H, Balkau B, Dekker JM, Lawlor DA, Daimon M, Willeit J, Njølstad I, Nissinen A, Brunner EJ, Kuller LH, Price JF, Sundström J, Knuiman MW, Feskens EJ, Verschuren WM, Wald N, Bakker SJ, Whincup PH, Ford I, Goldbourt U, Gómez de la Cámara A, Gallacher J, Simons LA, Rosengren A, Sutherland SE, Björkelund C, Blazer DG, Wassertheil Smoller S, Onat A, Marín Ibañez A, Casiglia E, Jukema JW, Simpson LM, Giampaoli S, Nordestgaard BG, Selmer R, Wennberg P, Kauhanen J, Salonen JT, Dankner R, Barrett Connor E, Kavousi M, Gudnason V, Evans D, Wallace RB, Cushman M, D'Agostino RB Sr, Umans JG, Kiyohara Y, Nakagawa H, Sato S, Gillum RF, Folsom AR, van der Schouw YT, Moons KG, Griffin SJ, Sattar N, Wareham NJ, Selvin E, Thompson SG, Danesh J. Collaborators Simpson LM, Coresh J, Wagenknecht L, Shaw JE, Zimmet PZ, Magliano D, Wannamethee SG, Morris RW, Kiechl S, Santer P, Bonora E, Casas JP, Ebrahim S, Ben Shlomo Y, Yarnell JW, Elwood P, Bachman DL, Nietert PJ, Håheim LL, Søgaard AJ, Tybjaerg Hansen A, Frikke Schmidt R, Benn M, Palmieri L, Vanuzzo D, Bonnet F, Copin N, Roussel R, Gómez Gerique JA, Rubio Herrera MA, Gutiérrez Fuentes JA, Friedlander Y, McCallum J, Simons J, Lee AJ, McLachlan S, Taylor JO, Guralnik JM, Phillips CL, Evans DA, Kohout F, Cohen H, George L, Fillenbaum G, McGloin JM, Khaw K., Schöttker B, Müller H, Rothenbacher D, Jansson J., Hallmans G, Tuomilehto J, Donfrancesco C, Woodward M, Oizumi T, Kayama T, Kato T, Danker R, Chetrit A, Wilhelmsen L, Eriksson H, Lappas G, Bengtsson C, Lissner L, Skoog I, Cremer P, Arima H, Ninomiya T, Hata J, Nijpels G, Stehouwer CD, Tuomainen T., Voutilainen S, Kurl S, de Boer IH, Bertoni AG, Veschuren WM, Dullaart RP, Lambers Heerspink HJ, Hilege HL, Trompet S, Stott DJ, Dagenais GR, Cantin B, Dehghan D, Hofman A, Franco OH, Tunstall Pedoe H, Lee E, Best L, Howard BV, Can G, Ademoğlu E, Sakurai M, Nakamura K, Morikawa Y, Løchen M., Mathiesen EB, Wilsgaard T, Byberg L, Cederholm T, Olsson E, Pradhan AD, Cook NR, Kromhout D, Walker M, Watson S, Burgess S, Gregson J, Harshfield E, Pennells L, Spackman S, Warnakula S, Wood AM, Danesh J., PANICO, SALVATORE, Emerging Risk Factors, Collaboration, Di Angelantonio, E, Gao, P, Khan, H, Butterworth, A, Wormser, D, Kaptoge, S, Kondapally Seshasai, Sr, Thompson, A, Sarwar, N, Willeit, P, Ridker, Pm, Barr, El, Khaw, Kt, Psaty, Bm, Brenner, H, Balkau, B, Dekker, Jm, Lawlor, Da, Daimon, M, Willeit, J, Njølstad, I, Nissinen, A, Brunner, Ej, Kuller, Lh, Price, Jf, Sundström, J, Knuiman, Mw, Feskens, Ej, Verschuren, Wm, Wald, N, Bakker, Sj, Whincup, Ph, Ford, I, Goldbourt, U, Gómez de la Cámara, A, Gallacher, J, Simons, La, Rosengren, A, Sutherland, Se, Björkelund, C, Blazer, Dg, Wassertheil Smoller, S, Onat, A, Marín Ibañez, A, Casiglia, E, Jukema, Jw, Simpson, Lm, Giampaoli, S, Nordestgaard, Bg, Selmer, R, Wennberg, P, Kauhanen, J, Salonen, Jt, Dankner, R, Barrett Connor, E, Kavousi, M, Gudnason, V, Evans, D, Wallace, Rb, Cushman, M, D'Agostino RB, Sr, Umans, Jg, Kiyohara, Y, Nakagawa, H, Sato, S, Gillum, Rf, Folsom, Ar, van der Schouw, Yt, Moons, Kg, Griffin, Sj, Sattar, N, Wareham, Nj, Selvin, E, Thompson, Sg, Danesh J., Collaborators Simpson LM, Coresh, J, Wagenknecht, L, Shaw, Je, Zimmet, Pz, Magliano, D, Wannamethee, Sg, Morris, Rw, Kiechl, S, Santer, P, Bonora, E, Casas, Jp, Ebrahim, S, Ben Shlomo, Y, Yarnell, Jw, Elwood, P, Bachman, Dl, Nietert, Pj, Håheim, Ll, Søgaard, Aj, Tybjaerg Hansen, A, Frikke Schmidt, R, Benn, M, Palmieri, L, Vanuzzo, D, Panico, Salvatore, Bonnet, F, Copin, N, Roussel, R, Gómez Gerique, Ja, Rubio Herrera, Ma, Gutiérrez Fuentes, Ja, Friedlander, Y, Mccallum, J, Simons, J, Lee, Aj, Mclachlan, S, Taylor, Jo, Guralnik, Jm, Phillips, Cl, Evans, Da, Kohout, F, Cohen, H, George, L, Fillenbaum, G, Mcgloin, Jm, Khaw, K., Schöttker, B, Müller, H, Rothenbacher, D, Jansson, J., Hallmans, G, Tuomilehto, J, Donfrancesco, C, Woodward, M, Oizumi, T, Kayama, T, Kato, T, Danker, R, Chetrit, A, Wilhelmsen, L, Eriksson, H, Lappas, G, Bengtsson, C, Lissner, L, Skoog, I, Cremer, P, Arima, H, Ninomiya, T, Hata, J, Nijpels, G, Stehouwer, Cd, Tuomainen, T., Voutilainen, S, Kurl, S, de Boer, Ih, Bertoni, Ag, Veschuren, Wm, Dullaart, Rp, Lambers Heerspink, Hj, Hilege, Hl, Trompet, S, Stott, Dj, Dagenais, Gr, Cantin, B, Dehghan, D, Hofman, A, Franco, Oh, Tunstall Pedoe, H, Lee, E, Best, L, Howard, Bv, Can, G, Ademoğlu, E, Sakurai, M, Nakamura, K, Morikawa, Y, Løchen, M., Mathiesen, Eb, Wilsgaard, T, Byberg, L, Cederholm, T, Olsson, E, Pradhan, Ad, Cook, Nr, Kromhout, D, Walker, M, Watson, S, Burgess, S, Gregson, J, Harshfield, E, Pennells, L, Spackman, S, Warnakula, S, Wood, Am, and Danesh, J.

Published
2014

217. The relationships between humor styles, shyness and automatic thoughts among university students

Author

Başak, B.E., Can, G., Başak, B.E., Can, G., and Yeditepe Üniversitesi

Subjects
fluids and secretions, genetic structures, education, Shyness, sense organs, Automatic thoughths, eye diseases, Humor styles, University students
Abstract

This study aimed to investigate the relationships between humor styles, shyness and automatic thoughts among university students. The sample of the study consisted of 422 university students. In order to obtain the research data, the humor styles questionnaire. The Shyness Scale and the Automatic Thoughts Scale were used. The data were analyzed using SPSS 15.0 package program; via t-test, correlation analysis and regression analysis methods. The results indicated that negative humor styles of the male students were significantly higher than those of the female students, while there were no significant differences according to gender in terms of positive humor styles. Additionally, it was found that positive humor styles negatively correlated with shyness and automatic thoughts, self defeating humor positively related with automatic thoughts; and aggressive humor positively related with two subscales of automatic thoughts. Other findings of the study indicated that shyness, personal adjustment and desire for change predicted together affiliative humor; shyness and hopelessness predicted together self-enhancing humor; negative feelings and thoughts towards oneself predicted aggressive humor; and negative feelings , thoughts towards oneself personal adjustment and desire for change predicted together self-defeating humor.

Published
2014

218. Comparison of Effectiveness regarding a Culinary Medicine Elective for Medical Students in Germany Delivered Virtually versus In-Person

Author

Selina Böttcher, Louisa Josefa Schonebeck, Laura Drösch, Anna Manuela Plogmann, Can Gero Leineweber, Seraphina Puderbach, Charlotte Buhre, Christoph Schmöcker, Uwe Neumann, and Thomas Ellrott

Subjects
culinary medicine, teaching kitchen, nutrition education for health professionals, hands-on cooking instructions, interprofessional education, nutrition knowledge, Nutrition. Foods and food supply, TX341-641
Abstract

(1) Background: The Culinary Medicine elective at the German medical schools of the universities of Göttingen, Giessen, and Brandenburg is a teaching kitchen-based elective aimed at training medical students on how to improve patient counselling on nutrition and lifestyle medicine topics. This curriculum was either delivered virtually (2021) or in-person (2022/2023). Changes in teaching effectiveness were evaluated. (2) Methods: The elective included seven modules in the teaching kitchen for 3 h each. It consisted of a short introduction and a hands-on interactive cooking part illustrating important dietary principles in different disease groups. The elective was conducted virtually in 2021 in a fully interactive setup using videoconference tools. Students in this cohort attended from their private kitchens whereas students in the in-person cohort (2022/2023) attended the same classes in the teaching kitchen. Standardized comparative self-assessment questionnaires on counselling competencies, nutrition knowledge, eating habits, and mental well-being (WHO-5) before and after the elective were used to determine teaching effectiveness. Paired and unpaired t-tests were performed to evaluate results. (3) Results: A total of 70 students (mean semester 6.3) were included in the virtual cohort, and 80 students (mean semester 6.3) were in the in-person cohort. In both, counselling competencies on 25 nutrition and lifestyle medicine topics increased significantly. Significant changes also occurred in most nutrition knowledge categories. Subjective well-being as well as personal attitudes towards nutrition counselling in medical practice improved significantly during the elective. Healthy eating habits improved in both groups as students ate significantly less unfavourable foods. There were no significant differences between the two groups apart from minor differences in nutrition knowledge. (4) Conclusions: The elective in Culinary Medicine improved students counselling competencies, nutrition knowledge, attitudes, well-being, and eating habits with no relevant difference between virtual and in-person teaching.

Published
2023
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219. Mechanistically distinct cancer-associated mTOR activation clusters predict sensitivity to rapamycin

Author

Steven K. Albanese, Song Han, Vanessa Rodrik-Outmezguine, James J. Hsieh, David J. Chen, Zhan Yao, Daniel L. Parton, Jianing Xu, Yiyu Dong, Toshinao Oyama, John D. Chodera, Chung-Han Lee, Emily H. Cheng, Neal Rosen, and Can G. Pham

Subjects
0301 basic medicine, Male, Mutation, Missense, mTORC1, Mice, SCID, Biology, Molecular Dynamics Simulation, DEPTOR, medicine.disease_cause, 03 medical and health sciences, Mice, Protein Domains, medicine, Animals, Humans, Kinase activity, RNA, Small Interfering, Carcinoma, Renal Cell, PI3K/AKT/mTOR pathway, Sirolimus, Mutation, Antibiotics, Antineoplastic, Kinase, Genome, Human, TOR Serine-Threonine Kinases, RPTOR, General Medicine, Kidney Neoplasms, 3. Good health, Kinetics, 030104 developmental biology, Von Hippel-Lindau Tumor Suppressor Protein, Cancer research, Female, medicine.drug, DNA Damage, Plasmids, Research Article
Abstract

Genomic studies have linked mTORC1 pathway-activating mutations with exceptional response to treatment with allosteric inhibitors of mTORC1 called rapalogs. Rapalogs are approved for selected cancer types, including kidney and breast cancers. Here, we used sequencing data from 22 human kidney cancer cases to identify the activating mechanisms conferred by mTOR mutations observed in human cancers and advance precision therapeutics. mTOR mutations that clustered in focal adhesion kinase targeting domain (FAT) and kinase domains enhanced mTORC1 kinase activity, decreased nutrient reliance, and increased cell size. We identified 3 distinct mechanisms of hyperactivation, including reduced binding to DEP domain-containing MTOR-interacting protein (DEPTOR), resistance to regulatory associated protein of mTOR-mediated (RAPTOR-mediated) suppression, and altered kinase kinetics. Of the 28 mTOR double mutants, activating mutations could be divided into 6 complementation groups, resulting in synergistic Rag- and Ras homolog enriched in brain-independent (RHEB-independent) mTORC1 activation. mTOR mutants were resistant to DNA damage-inducible transcript 1-mediated (REDD1-mediated) inhibition, confirming that activating mutations can bypass the negative feedback pathway formed between HIF1 and mTORC1 in the absence of von Hippel-Lindau (VHL) tumor suppressor expression. Moreover, VHL-deficient cells that expressed activating mTOR mutants grew tumors that were sensitive to rapamycin treatment. These data may explain the high incidence of mTOR mutations observed in clear cell kidney cancer, where VHL loss and HIF activation is pathognomonic. Our study provides mechanistic and therapeutic insights concerning mTOR mutations in human diseases.

Published
2015

221. Observation of the B0 → ρ0ρ0 decay from an amplitude analysis of B0 → (π+π−)(π+π−) decays

Author

Aaij, R., Adeva, B., Adinolfi, M., Affolder, A., Ajaltouni, Z., Akar, S., Albrecht, J., Alessio, F., Alexander, M., Ali, S., Alkhazov, G., Alvarez Cartelle, P., Alves, A.A., Jr, Amato, S., Amerio, S., Amhis, Y., An, L., Anderlini, L., Anderson, J., Andreotti, M., Andrews, J.E., Appleby, R.B., Aquines Gutierrez, O., Archilli, F., Artamonov, A., Artuso, M., Aslanides, E., Auriemma, G., Baalouch, M., Bachmann, S., Back, J.J., Badalov, A., Baesso, C., Baldini, W., Barlow, R.J., Barschel, C., Barsuk, S., Barter, W., Batozskaya, V., Battista, V., Bay, A., Beaucourt, L., Beddow, J., Bedeschi, F., Bediaga, I., Bel, L.J., Belyaev, I., Ben-Haim, E., Bencivenni, G., Benson, S., Benton, J., Berezhnoy, A., Bernet, R., Bertolin, A., Bettler, M.-O., van Beuzekom, M., Bien, A., Bifani, S., Bird, T., Bizzeti, A., Blake, T., Blanc, F., Blouw, J., Blusk, S., Bocci, V., Bondar, A., Bondar, N., Bonivento, W., Borghi, S., Borsato, M., Bowcock, T.J.V., Bowen, E., Bozzi, C., Braun, S., Brett, D., Britsch, M., Britton, T., Brodzicka, J., Brook, N.H., Bursche, A., Buytaert, J., Cadeddu, S., Calabrese, R., Calvi, M., Calvo Gomez, M., Campana, P., Campora Perez, D., Capriotti, L., Carbone, A., Carboni, G., Cardinale, R., Cardini, A., Carniti, P., Carson, L., Carvalho Akiba, K., Casanova Mohr, R., Can, G., Cassina, L., Castillo Garcia, L., Cattaneo, M., Cauet, Ch., Cavallero, G., Cenci, R., Charles, M., Charpentier, Ph., Chefdeville, M., Chen, S., Cheung, S.-F., Chiapolini, N., Chrzaszcz, M., Cid Vidal, X., Ciezarek, G., Clarke, P.E.L., Clemencic, M., Cliff, H.V., Closier, J., Coco, V., Cogan, J., Cogneras, E., Cogoni, V., Cojocariu, L., Collazuol, G., Collins, P., Comerma-Montells, A., Contu, A., Cook, A., Coombes, M., Coquereau, S., Corti, G., Corvo, M., Counts, I., Couturier, B., Cowan, G.A., Craik, D.C., Crocombe, A.C., Cruz Torres, M., Cunliffe, S., Currie, R., D'Ambrosio, C., Dalseno, J., David, P.N.Y., Davis, A., De Bruyn, K., De Capua, S., De Cian, M., De Miranda, J.M., De Paula, L., De Silva, W., De Simone, P., Dean, C.-T., Decamp, D., Deckenhoff, M., Del Buono, L., Déléage, N., Derkach, D., Deschamps, O., Dettori, F., Dey, B., Di Canto, A., Di Ruscio, F., Dijkstra, H., Donleavy, S., Dordei, F., Dorigo, M., Dosil Suárez, A., Dossett, D., Dovbnya, A., Dreimanis, K., Dujany, G., Dupertuis, F., Durante, P., Dzhelyadin, R., Dziurda, A., Dzyuba, A., Easo, S., Egede, U., Egorychev, V., Eidelman, S., Eisenhardt, S., Eitschberger, U., Ekelhof, R., Eklund, L., El Rifai, I., Elsasser, Ch., Ely, S., Esen, S., Evans, H.M., Evans, T., Falabella, A., Färber, C., Farinelli, C., Farley, N., Farry, S., Fay, R., Ferguson, D., Fernandez Albor, V., Ferrari, F., Ferreira Rodrigues, F., Ferro-Luzzi, M., Filippov, S., Fiore, M., Fiorini, M., Firlej, M., Fitzpatrick, C., Fiutowski, T., Fol, P., Fontana, M., Fontanelli, F., Forty, R., Francisco, O., Frank, M., Frei, C., Frosini, M., Fu, J., Furfaro, E., Gallas Torreira, A., Galli, D., Gallorini, S., Gambetta, S., Gandelman, M., Gandini, P., Gao, Y., García Pardiñas, J., Garofoli, J., Garra Tico, J., Garrido, L., Gascon, D., Gaspar, C., Gastaldi, U., Gauld, R., Gavardi, L., Gazzoni, G., Geraci, A., Gerick, D., Gersabeck, E., Gersabeck, M., Gershon, T., Ghez, Ph., Gianelle, A., Gianì, S., Gibson, V., Giubega, L., Gligorov, V.V., Göbel, C., Golubkov, D., Golutvin, A., Gomes, A., Gotti, C., Grabalosa Gándara, M., Graciani Diaz, R., Granado Cardoso, L.A., Graugés, E., Graverini, E., Graziani, G., Grecu, A., Greening, E., Gregson, S., Griffith, P., Grillo, L., Grünberg, O., Gui, B., Gushchin, E., Guz, Yu., Gys, T., Hadjivasiliou, C., Haefeli, G., Haen, C., Haines, S.C., Hall, S., Hamilton, B., Hampson, T., Han, X., Hansmann-Menzemer, S., Harnew, N., Harnew, S.T., Harrison, J., He, J., Head, T., Heijne, V., Hennessy, K., Henrard, P., Henry, L., Hernando Morata, J.A., van Herwijnen, E., Heß, M., Hicheur, A., Hill, D., Hoballah, M., Hombach, C., Hulsbergen, W., Humair, T., Hussain, N., Hutchcroft, D., Hynds, D., Idzik, M., Ilten, P., Jacobsson, R., Jaeger, A., Jalocha, J., Jans, E., Jawahery, A., Jing, F., John, M., Johnson, D., Jones, C.R., Joram, C., Jost, B., Jurik, N., Kandybei, S., Kanso, W., Karacson, M., Karbach, T.M., Karodia, S., Kelsey, M., Kenyon, I.R., Kenzie, M., Ketel, T., Khanji, B., Khurewathanakul, C., Klaver, S., Klimaszewski, K., Kochebina, O., Kolpin, M., Komarov, I., Koopman, R.F., Koppenburg, P., Korolev, M., Kravchuk, L., Kreplin, K., Kreps, M., Krocker, G., Krokovny, P., Kruse, F., Kucewicz, W., Kucharczyk, M., Kudryavtsev, V., Kurek, K., Kvaratskheliya, T., La Thi, V.N., Lacarrere, D., Lafferty, G., Lai, A., Lambert, D., Lambert, R.W., Lanfranchi, G., Langenbruch, C., Langhans, B., Latham, T., Lazzeroni, C., Le Gac, R., van Leerdam, J., Lees, J.-P., Lefèvre, R., Leflat, A., Lefrançois, J., Leroy, O., Lesiak, T., Leverington, B., Li, Y., Likhomanenko, T., Liles, M., Lindner, R., Linn, C., Lionetto, F., Liu, B., Lohn, S., Longstaff, I., Lopes, J.H., Lowdon, P., Lucchesi, D., Luo, H., Lupato, A., Luppi, E., Lupton, O., Machefert, F., Maciuc, F., Maev, O., Malde, S., Malinin, A., Manca, G., Mancinelli, G., Manning, P., Mapelli, A., Maratas, J., Marchand, J.F., Marconi, U., Marin Benito, C., Marino, P., Märki, R., Marks, J., Martellotti, G., Martinelli, M., Martinez Santos, D., Martinez Vidal, F., Martins Tostes, D., Massafferri, A., Matev, R., Mathad, A., Mathe, Z., Matteuzzi, C., Mauri, A., Maurin, B., Mazurov, A., McCann, M., McCarthy, J., McNab, A., McNulty, R., Meadows, B., Meier, F., Meissner, M., Merk, M., Milanes, D.A., Minard, M.-N., Mitzel, D.S., Molina Rodriguez, J., Monteil, S., Morandin, M., Morawski, P., Mordà, A., Morello, M.J., Moron, J., Morris, A.-B., Mountain, R., Muheim, F., Müller, K., Mussini, M., Muster, B., Naik, P., Nakada, T., Nandakumar, R., Nasteva, I., Needham, M., Neri, N., Neubert, S., Neufeld, N., Neuner, M., Nguyen, A.D., Nguyen, T.D., Nguyen-Mau, C., Niess, V., Niet, R., Nikitin, N., Nikodem, T., Novoselov, A., O'Hanlon, D.P., Oblakowska-Mucha, A., Obraztsov, V., Ogilvy, S., Okhrimenko, O., Oldeman, R., Onderwater, C.J.G., Osorio Rodrigues, B., Otalora Goicochea, J.M., Otto, A., Owen, P., Oyanguren, A., Palano, A., Palombo, F., Palutan, M., Panman, J., Papanestis, A., Pappagallo, M., Pappalardo, L.L., Parkes, C., Passaleva, G., Patel, G.D., Patel, M., Patrignani, C., Pearce, A., Pellegrino, A., Penso, G., Pepe Altarelli, M., Perazzini, S., Perret, P., Pescatore, L., Petridis, K., Petrolini, A., Picatoste Olloqui, E., Pietrzyk, B., Pilař, T., Pinci, D., Pistone, A., Playfer, S., Plo Casasus, M., Poikela, T., Polci, F., Poluektov, A., Polyakov, I., Polycarpo, E., Popov, A., Popov, D., Popovici, B., Potterat, C., Price, E., Price, J.D., Prisciandaro, J., Pritchard, A., Prouve, C., Pugatch, V., Puig Navarro, A., Punzi, G., Qian, W., Quagliani, R., Rachwal, B., Rademacker, J.H., Rakotomiaramanana, B., Rama, M., Rangel, M.S., Raniuk, I., Rauschmayr, N., Raven, G., Redi, F., Reichert, S., Reid, M.M., dos Reis, A.C., Ricciardi, S., Richards, S., Rihl, M., Rinnert, K., Rives Molina, V., Robbe, P., Rodrigues, A.B., Rodrigues, E., Rodriguez Lopez, J.A., Rodriguez Perez, P., Roiser, S., Romanovsky, V., Romero Vidal, A., Rotondo, M., Rouvinet, J., Ruf, T., Ruiz, H., Ruiz Valls, P., Saborido Silva, J.J., Sagidova, N., Sail, P., Saitta, B., Salustino Guimaraes, V., Sanchez Mayordomo, C., Sanmartin Sedes, B., Santacesaria, R., Santamarina Rios, C., Santovetti, E., Sarti, A., Satriano, C., Satta, A., Saunders, D.M., Savrina, D., Schiller, M., Schindler, H., Schlupp, M., Schmelling, M., Schmidt, B., Schneider, O., Schopper, A., Schune, M.-H., Schwemmer, R., Sciascia, B., Sciubba, A., Semennikov, A., Sepp, I., Serra, N., Serrano, J., Sestini, L., Seyfert, P., Shapkin, M., Shapoval, I., Shcheglov, Y., Shears, T., Shekhtman, L., Shevchenko, V., Shires, A., Silva Coutinho, R., Simi, G., Sirendi, M., Skidmore, N., Skillicorn, I., Skwarnicki, T., Smith, N.A., Smith, E., Smith, J., Smith, M., Snoek, H., Sokoloff, M.D., Soler, F.J.P., Soomro, F., Souza, D., Souza De Paula, B., Spaan, B., Spradlin, P., Sridharan, S., Stagni, F., Stahl, M., Stahl, S., Steinkamp, O., Stenyakin, O., Sterpka, F., Stevenson, S., Stoica, S., Stone, S., Storaci, B., Stracka, S., Straticiuc, M., Straumann, U., Stroili, R., Sun, L., Sutcliffe, W., Swientek, K., Swientek, S., Syropoulos, V., Szczekowski, M., Szczypka, P., Szumlak, T., T'Jampens, S., Teklishyn, M., Tellarini, G., Teubert, F., Thomas, C., Thomas, E., van Tilburg, J., Tisserand, V., Tobin, M., Todd, J., Tolk, S., Tomassetti, L., Tonelli, D., Topp-Joergensen, S., Torr, N., Tournefier, E., Tourneur, S., Trabelsi, K., Tran, M.T., Tresch, M., Trisovic, A., Tsaregorodtsev, A., Tsopelas, P., Tuning, N., Ukleja, A., Ustyuzhanin, A., Uwer, U., Vacca, C., Vagnoni, V., Valenti, G., Vallier, A., Vazquez Gomez, R., Vazquez Regueiro, P., Vázquez Sierra, C., Vecchi, S., Velthuis, J.J., Veltri, M., Veneziano, G., Vesterinen, M., Viana Barbosa, J.V., Viaud, B., Vieira, D., Vieites Diaz, M., Vilasis-Cardona, X., Vollhardt, A., Volyanskyy, D., Voong, D., Vorobyev, A., Vorobyev, V., Voß, C., de Vries, J.A., Waldi, R., Wallace, C., Wallace, R., Walsh, J., Wandernoth, S., Wang, J., Ward, D.R., Watson, N.K., Websdale, D., Weiden, A., Whitehead, M., Wiedner, D., Wilkinson, G., Wilkinson, M., Williams, M., Williams, M.P., Wilson, F.F., Wimberley, J., Wishahi, J., Wislicki, W., Witek, M., Wormser, G., Wotton, S.A., Wright, S., Wyllie, K., Xie, Y., Xu, Z., Yang, Z., Yuan, X., Yushchenko, O., Zangoli, M., Zavertyaev, M., Zhang, L., Zhang, Y., Zhelezov, A., Zhokhov, A., and Zhong, L.

Published
2015
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222. Regulatory pathways and drugs associated with ferroptosis in tumors

Author

Dan Wang, Le Tang, Yijie Zhang, Guili Ge, Xianjie Jiang, Yongzhen Mo, Pan Wu, Xiangying Deng, Lvyuan Li, Sicheng Zuo, Qijia Yan, Shanshan Zhang, Fuyan Wang, Lei Shi, Xiayu Li, Bo Xiang, Ming Zhou, Qianjin Liao, Can Guo, Zhaoyang Zeng, Wei Xiong, and Zhaojian Gong

Subjects
Cytology, QH573-671
Abstract

Abstract Ferroptosis is a type of cell death that depends on iron and reactive oxygen species (ROS). The accumulation of iron and lipid peroxidation primarily initiates oxidative membrane damage during ferroptosis. The core molecular mechanism of ferroptosis includes the regulation of oxidation and the balance between damage and antioxidant defense. Tumor cells usually contain a large amount of H2O2, and ferrous/iron ions will react with excessive H2O2 in cells to produce hydroxyl radicals and induce ferroptosis in tumor cells. Here, we reviewed the latest studies on the regulation of ferroptosis in tumor cells and introduced the tumor-related signaling pathways of ferroptosis. We paid particular attention to the role of noncoding RNA, nanomaterials, the role of drugs, and targeted treatment using ferroptosis drugs for mediating the ferroptosis process in tumor cells. Finally, we discussed the currently unresolved problems and future research directions for ferroptosis in tumor cells and the prospects of this emerging field. Therefore, we have attempted to provide a reference for further understanding of the pathogenesis of ferroptosis and proposed new targets for cancer treatment.

Published
2022
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223. Sustainability of the rice–crayfish farming model in waterlogged land: A case study in Qianjiang County, Hubei Province, China

Author

Peng-li YUAN, Jin-ping WANG, Can GUO, Zi-yuan GUO, Yao GUO, and Cou-gui CAO

Subjects
rice–crayfish, benefit–cost ratio, lodging, nitrogen application, Agriculture (General), S1-972
Abstract

The rice–crayfish farming model has been rapidly developed and become an economically viable method to supply food in China in recent years. However, its environmental and economic sustainability has not been thoroughly investigated. This study uses a survey in 2016 and a field experiment in 2017 in Qianjiang, Hubei Province, China to assess the relative economics of concurrent rice–wheat (RW), rice–crayfish (RC), and crayfish monoculture (CM) models in waterlogged land areas. The field survey indicated that the RC model had a higher benefit–cost ratio (3.5:1) than the RW (2.0:1) and CM (3.1:1) models and the RC model protected farmers’ enthusiasm for grain production facing unfavourable weather conditions. The field experiment aimed to explore nitrogen management strategies in RC fields. In the experiment, four levels of nitrogen concentration gradient - 0 kg N ha−1 (0 N), 75 kg N ha−1 (75 N), 150 kg N ha−1 (150 N) and 225 kg N ha−1 (225 N), were set in a 2-year-old rice–crayfish (RC2) field, an 8-year-old rice–crayfish (RC8) field, and a RW field as a control. The field experiment results suggested that the peak rice yield in RW, RC2, and RC8 occurred when 225 N, 150 N and 75 N were used, respectively. In RC2 and RC8, however, residual feed-nitrogen that was not used by crayfish was utilized by rice plants. Thus, an optimal amount of nitrogen in RC fields was proposed to improve the nitrogen use efficiency and reduce environmental pollution by nitrogen fertilizer. Farmers use less nitrogen but have higher net income in RC than in RW and CM. It is necessary to sustainably develop integrated farming technologies (i.e., proper field configurations for rice fields) to effectively sustain rice production. The results also showed that the RC farming model was a viable diversification option for rice farmers in waterlogged land.

Published
2022
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224. FOLDED ANGLE DEPENDENT MODAL ANALYSIS OF THE FLAT AND FOLDED PLATES

Author

Can Gönenli

Subjects
büküm açısı, serbest titreşim analizi, sonlu elemanlar yöntemi, i̇nce plaka, modal analiz, folded angle, free vibration analysis, finite element method, thin plate, modal analysis, Technology, Engineering (General). Civil engineering (General), TA1-2040
Abstract

The effect of folded angle and boundary condition differences on the natural frequency, which is one of the dynamic characteristics of isotropic thin plates, is investigated. Modal analyzes of flat and folded structures are performed with ANSYS under cantilever and two-side-fixed boundary conditions. The validation of the free vibration results of the structures is performed with Solidworks. The first five natural frequencies of each structure are obtained, and the values in terms of non-dimensional natural frequency parameters are interpreted with the tables and graphics. While both an increase and a decrease can be observed depending on the increase in the folded angle in the first five natural frequencies for the cantilever boundary condition, the effect of the increase in the folded angle on the natural frequencies in the two-sided-fixed structures is much less in the higher folded angle values. It is seen that the reason for the sudden changes in the folded angle - non-dimensional natural frequency graphs is the mode shape change.

Published
2022
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231. The SWI/SNF Protein PBRM1 Restrains VHL-Loss-Driven Clear Cell Renal Cell Carcinoma

Author

Nargund, Amrita M., primary, Pham, Can G., additional, Dong, Yiyu, additional, Wang, Patricia I., additional, Osmangeyoglu, Hatice U., additional, Xie, Yuchen, additional, Aras, Omer, additional, Han, Song, additional, Oyama, Toshinao, additional, Takeda, Shugaku, additional, Ray, Chelsea E., additional, Dong, Zhenghong, additional, Berge, Mathieu, additional, Hakimi, A. Ari, additional, Monette, Sebastien, additional, Lekaye, Carl L., additional, Koutcher, Jason A., additional, Leslie, Christina S., additional, Creighton, Chad J., additional, Weinhold, Nils, additional, Lee, William, additional, Tickoo, Satish K., additional, Wang, Zhong, additional, Cheng, Emily H., additional, and Hsieh, James J., additional

Published
2017
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232. Individual and combined effects of arbuscular mycorrhizal fungi and phytohormones on the growth and physiobiochemical characteristics of tea cutting seedlings

Author

Xiubing GAO, Yan LIU, Chunyan LIU, Can GUO, Yuan ZHANG, Chiyu MA, and Xueyi DUAN

Subjects
Camellia sinensis, mycorrhiza, antioxidase, polyamines, strigolactone, Plant culture, SB1-1110
Abstract

Both arbuscular mycorrhizal fungi (AMF) and phytohormones collectively regulate plant growth and root development, but their individual and combined effects on tea [Camellia sinensis (L.) O. Kuntze] cutting seedings remain unclear. This study examined the individual and combined effects of two species of AMF (Rhizophagus intraradices, RI and Funneliformis mosseae, FM) and two types of palnt hormones (strigolactones, SLs; polyamines, PAs) on tea cutting seedings, by evaluating the growth and physiobiochemical characteristics of plants treated with the AMFs and/or hormones. The results showed that inoculation with either AMF individually or hormones treatment alone could significantly enhanced mycorrhizal colonization, growth target and physiobiochemical characteristics of tea cutting seedlings. Interestingly, the addition of a combination of AMFs and hormones showed superior effects, while SL and RI exhibited the most improvements to the colonization rate, plant growth, root-morphological traits, root DHA activity, photosynthesis, chlorophyll content, soluble sugar content in leaves, and the activities of antioxidant enzymes (SOD, POD, and CAT), compared to other treatment combinations (SL + FM, PA + RI, and PA + FM). Correlation analyses revealed a significantly (p < 0.05) positive correlation of root AMF colonization with root-related traits (e.g., DHA, root total length, surface area, and volume) and leaf-related traits (e.g., leaf area, shoot biomass, total chlorophyll, and antioxidant enzyme activities). This study demonstrated that while the apllication of individual AMF or plant hormones had a certain good effects on most growth and physiobiochemical characteristics parameters of tea cutting seedings, the additive effect was from specific combined of AMF and plant hormones. These results highlight the possibility for combined of AMF and plant hormones to improve the asexual reproduction of tea plants via cuttings.

Published
2023
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233. Data processing pipeline for cardiogenic shock prediction using machine learning

Author

Nikola Jajcay, Branislav Bezak, Amitai Segev, Shlomi Matetzky, Jana Jankova, Michael Spartalis, Mohammad El Tahlawi, Federico Guerra, Julian Friebel, Tharusan Thevathasan, Imrich Berta, Leo Pölzl, Felix Nägele, Edita Pogran, F. Aaysha Cader, Milana Jarakovic, Can Gollmann-Tepeköylü, Marta Kollarova, Katarina Petrikova, Otilia Tica, Konstantin A. Krychtiuk, Guido Tavazzi, Carsten Skurk, Kurt Huber, and Allan Böhm

Subjects
classification, machine learning, missing data imputation, processing pipeline, prediction model, cardiogenic shock, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

IntroductionRecent advances in machine learning provide new possibilities to process and analyse observational patient data to predict patient outcomes. In this paper, we introduce a data processing pipeline for cardiogenic shock (CS) prediction from the MIMIC III database of intensive cardiac care unit patients with acute coronary syndrome. The ability to identify high-risk patients could possibly allow taking pre-emptive measures and thus prevent the development of CS.MethodsWe mainly focus on techniques for the imputation of missing data by generating a pipeline for imputation and comparing the performance of various multivariate imputation algorithms, including k-nearest neighbours, two singular value decomposition (SVD)—based methods, and Multiple Imputation by Chained Equations. After imputation, we select the final subjects and variables from the imputed dataset and showcase the performance of the gradient-boosted framework that uses a tree-based classifier for cardiogenic shock prediction.ResultsWe achieved good classification performance thanks to data cleaning and imputation (cross-validated mean area under the curve 0.805) without hyperparameter optimization.ConclusionWe believe our pre-processing pipeline would prove helpful also for other classification and regression experiments.

Published
2023
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234. Prefabricated platinum nanomaterial matrix for MALDI-MS imaging of oligosaccharides and lipids in plant tissues

Author

Yu-Lin Shen, Si-Jia Zhuang, Fan Yang, Can Gong, and Xu Xu

Subjects
matrix-assisted laser desorption ionization mass spectrometry imaging, matrix, platinum nanomaterials, plant tissue, oligosaccharide, lipid, Plant culture, SB1-1110
Abstract

Matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI-MSI) can visualize the spatial distribution characteristics of molecules in tissues in situ, in which the matrix plays a key role. In this paper, we propose a platinum nanomaterial pre-coated matrix, which can be prepared in bulk by sputtering platinum nanoparticles onto slides using an ion sputterer and then used for MALDI-MS analysis by placing tissue sections on the matrix. We used this matrix for MALDI-MS imaging analysis of corn kernels and germinated wheat sections, and the results show that triacylglycerides were mainly distributed in the embryo of corn kernels and germinated wheat, and sugars were mainly distributed in the endosperm, with the highest content of disaccharides.It provides a simple and reliable experimental condition for analyzing the distribution of oligosaccharide and lipid components in plant tissues.

Published
2023
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236. Ferritin heavy chain upregulation by NF-KappaB inhibits TNF alpha-induced apoptosis by suppressing reactive oxygen species

Author

Can G. Pham, Bubici, Concetta, Zazzeroni, Francesca, Jones, Joy, Papa, Salvatore, Alvarez, Kellean, Jayawardena, Shanthi, De Smaele, Enrico, Beaumont, Carole, Rong Cong, Torti, Frank M., Franzoso, Guido, and Torti, Suzy V.

Subjects
Tumor necrosis factor -- Research, Genetic transcription -- Research, Genetic research, Biological sciences
Abstract

A ferritin heavy chain (FHC), the primary iron storage factor, is identified in a study as an essential mediator of the antioxidant and protective activities of NF-KappaB. The antiapoptotic activity of FHC functions to inhibit induction of reactive oxygen species (ROS) and, thereby, activation of c-Jun N-terminal kinase (JNK) by tumor necrosis factor (TNF)alpha.

Published
2004

237. The opinions of adults about the ban on cigarette sales to minors

Author

Ozcebe, H., primary, Bilir, N., additional, Inal, E., additional, Unlu, H., additional, Beser, E., additional, Can, G., additional, Evci Kiraz, E. D., additional, Okyay, P., additional, Arslantas, D., additional, Abacigil, F., additional, Senol, V., additional, Turhan, E., additional, Gokgoz, S., additional, Calıkoglu, E. O., additional, and Kocan, Z., additional

Published
2016
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239. Provision of spiritual care to advanced cancer patients by doctors and nurses in the Middle East

Author

Bar-Sela, G., primary, Schultz, M., additional, Khader, K., additional, Rassouli, M., additional, Doumit, M., additional, Ghrayeb, I., additional, Kebudi, R., additional, Elshamy, K., additional, Al-Jadiry, M. Faisal, additional, Fahmi, R., additional, Charalambous, H., additional, Razaq, S., additional, Gafer, N., additional, Can, G., additional, Obeidat, R., additional, Punjwani, R., additional, Ayyash, H., additional, Khleif, M., additional, Najajreh, M., additional, and Silbermann, M., additional

Published
2016
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240. Observation of the → Decay From an Amplitude Analysis of → ( )( ) Decays

Author

Aaij, R., Adeva, B., Adinolfi, M., Affolder, A., Ajaltouni, Z., Akar, S., Albrecht, J., Alessio, F., Alexander, M., Ali, S., Alkhazov, G., Alvarez Cartelle, P., Alves, A.A., Amato, S., Amerio, S., Amhis, Y., An, L., Anderlini, L., Anderson, J., Andreotti, M., Andrews, J.E., Appleby, R.B., Aquines Gutierrez, O., Archilli, F., Artamonov, A., Artuso, M., Aslanides, E., Auriemma, G., Baalouch, M., Bachmann, S., Back, J.J., Badalov, A., Baesso, C., Baldini, W., Barlow, R.J., Barschel, C., Barsuk, S., Barter, W., Batozskaya, V., Battista, V., Bay, A., Beaucourt, L., Beddow, J., Bedeschi, F., Bediaga, I., Bel, L.J., Belyaev, I., Ben-Haim, E., Bencivenni, G., Benson, S., Benton, J., Berezhnoy, A., Bernet, R., Bertolin, A., Bettler, M.O., van Beuzekom, M., Bien, A., Bifani, S., Bird, T., Bizzeti, A., Blake, T., Blanc, F., Blouw, J., Blusk, S., Bocci, V., Bondar, A., Bondar, N., Bonivento, W., Borghi, S., Borsato, M., Bowcock, T.J.V., Bowen, E., Bozzi, C., Braun, S., Brett, D., Britsch, M., Britton, T., Brodzicka, J., Brook, N.H., Bursche, A., Buytaert, J., Cadeddu, S., Calabrese, R., Calvi, M., Calvo Gomez, M., Campana, P., Campora Perez, D., Capriotti, L., Carbone, A., Carboni, G., Cardinale, R., Cardini, A., Carniti, P., Carson, L., Carvalho Akiba, K., Casanova Mohr, R., Can, G., Cassina, L., Castillo Garcia, L., Cattaneo, M., Cauet, Ch., Cavallero, G., Cenci, R., Charles, M., Charpentier, Ph., Chefdeville, M., Chen, S., Cheung, S.F., Chiapolini, N., Chrzaszcz, M., Cid Vidal, X., Ciezarek, G., Clarke, P.E.L., Clemencic, M., Cliff, H.V., Closier, J., Coco, V., Cogan, J., Cogneras, E., Cogoni, V., Cojocariu, L., Collazuol, G., Collins, P., Comerma-Montells, A., Contu, A., Cook, A., Coombes, M., Coquereau, S., Corti, G., Corvo, M., Counts, I., Couturier, B., Cowan, G.A., Craik, D.C., Crocombe, A.C., Cruz Torres, M., Cunliffe, S., Currie, R., D'Ambrosio, C., Dalseno, J., David, P.N.Y., Davis, A., De Bruyn, K., De Capua, S., De Cian, M., De Miranda, J.M., De Paula, L., De Silva, W., De Simone, P., Dean, C.T., Decamp, D., Deckenhoff, M., Del Buono, L., Déléage, N., Derkach, D., Deschamps, O., Dettori, F., Dey, B., Di Canto, A., Di Ruscio, F., Dijkstra, H., Donleavy, S., Dordei, F., Dorigo, M., Dosil Suárez, A., Dossett, D., Dovbnya, A., Dreimanis, K., Dujany, G., Dupertuis, F., Durante, P., Dzhelyadin, R., Dziurda, A., Dzyuba, A., Easo, S., Egede, U., Egorychev, V., Eidelman, S., Eisenhardt, S., Eitschberger, U., Ekelhof, R., Eklund, L., El Rifai, I., Elsasser, Ch., Ely, S., Esen, S., Evans, H.M., Evans, T., Falabella, A., Färber, C., Farinelli, C., Farley, N., Farry, S., Fay, R., Ferguson, D., Fernandez Albor, V., Ferrari, F., Ferreira Rodrigues, F., Ferro-Luzzi, M., Filippov, S., Fiore, M., Fiorini, M., Firlej, M., Fitzpatrick, C., Fiutowski, T., Fol, P., Fontana, M., Fontanelli, F., Forty, R., Francisco, O., Frank, M., Frei, C., Frosini, M., Fu, J., Furfaro, E., Gallas Torreira, A., Galli, D., Gallorini, S., Gambetta, S., Gandelman, M., Gandini, P., Gao, Y., García Pardiñas, J., Garofoli, J., Garra Tico, J., Garrido, L., Gascon, D., Gaspar, C., Gastaldi, U., Gauld, R., Gavardi, L., Gazzoni, G., Geraci, A., Gerick, D., Gersabeck, E., Gersabeck, M., Gershon, T., Ghez, Ph., Gianelle, A., Gianì, S., Gibson, V., Giubega, L., Gligorov, V.V., Göbel, C., Golubkov, D., Golutvin, A., Gomes, A., Gotti, C., Grabalosa Gándara, M., Graciani Diaz, R., Granado Cardoso, L.A., Graugés, E., Graverini, E., Graziani, G., Grecu, A., Greening, E., Gregson, S., Griffith, P., Grillo, L., Grünberg, O., Gui, B., Gushchin, E., Guz, Yu., Gys, T., Hadjivasiliou, C., Haefeli, G., Haen, C., Haines, S.C., Hall, S., Hamilton, B., Hampson, T., Han, X., Hansmann-Menzemer, S., Harnew, N., Harnew, S.T., Harrison, J., He, J., Head, T., Heijne, V., Hennessy, K., Henrard, P., Henry, L., Hernando Morata, J.A., van Herwijnen, E., Heß, M., Hicheur, A., Hill, D., Hoballah, M., Hombach, C., Hulsbergen, W., Humair, T., Hussain, N., Hutchcroft, D., Hynds, D., Idzik, M., Ilten, P., Jacobsson, R., Jaeger, A., Jalocha, J., Jans, E., Jawahery, A., Jing, F., John, M., Johnson, D., Jones, C.R., Joram, C., Jost, B., Jurik, N., Kandybei, S., Kanso, W., Karacson, M., Karbach, T.M., Karodia, S., Kelsey, M., Kenyon, I.R., Kenzie, M., Ketel, T., Khanji, B., Khurewathanakul, C., Klaver, S., Klimaszewski, K., Kochebina, O., Kolpin, M., Komarov, I., Koopman, R.F., Koppenburg, P., Korolev, M., Kravchuk, L., Kreplin, K., Kreps, M., Krocker, G., Krokovny, P., Kruse, F., Kucewicz, W., Kucharczyk, M., Kudryavtsev, V., Kurek, K., Kvaratskheliya, T., La Thi, V.N., Lacarrere, D., Lafferty, G., Lai, A., Lambert, D., Lambert, R.W., Lanfranchi, G., Langenbruch, C., Langhans, B., Latham, T., Lazzeroni, C., Le Gac, R., van Leerdam, J., Lees, J.P., Lefèvre, R., Leflat, A., Lefrançois, J., Leroy, O., Lesiak, T., Leverington, B., Li, Y., Likhomanenko, T., Liles, M., Lindner, R., Linn, C., Lionetto, F., Liu, B., Lohn, S., Longstaff, I., Lopes, J.H., Lowdon, P., Lucchesi, D., Luo, H., Lupato, A., Luppi, E., Lupton, O., Machefert, F., Maciuc, F., Maev, O., Malde, S., Malinin, A., Manca, G., Mancinelli, G., Manning, P., Mapelli, A., Maratas, J., Marchand, J.F., Marconi, U., Marin Benito, C., Marino, P., Märki, R., Marks, J., Martellotti, G., Martinelli, M., Martinez Santos, D., Martinez Vidal, F., Martins Tostes, D., Massafferri, A., Matev, R., Mathad, A., Mathe, Z., Matteuzzi, C., Mauri, A., Maurin, B., Mazurov, A., McCann, M., McCarthy, J., McNab, A., McNulty, R., Meadows, B., Meier, F., Meissner, M., Merk, M., Milanes, D.A., Minard, M.N., Mitzel, D.S., Molina Rodriguez, J., Monteil, S., Morandin, M., Morawski, P., Mordà, A., Morello, M.J., Moron, J., Morris, A.B., Mountain, R., Muheim, F., Müller, K., Mussini, M., Muster, B., Naik, P., Nakada, T., Nandakumar, R., Nasteva, I., Needham, M., Neri, N., Neubert, S., Neufeld, N., Neuner, M., Nguyen, A.D., Nguyen, T.D., Nguyen-Mau, C., Niess, V., Niet, R., Nikitin, N., Nikodem, T., Novoselov, A., O'Hanlon, D.P., Oblakowska-Mucha, A., Obraztsov, V., Ogilvy, S., Okhrimenko, O., Oldeman, R., Onderwater, C.J.G., Osorio Rodrigues, B., Otalora Goicochea, J.M., Otto, A., Owen, P., Oyanguren, A., Palano, A., Palombo, F., Palutan, M., Panman, J., Papanestis, A., Pappagallo, M., Pappalardo, L.L., Parkes, C., Passaleva, G., Patel, G.D., Patel, M., Patrignani, C., Pearce, A., Pellegrino, A., Penso, G., Pepe Altarelli, M., Perazzini, S., Perret, P., Pescatore, L., Petridis, K., Petrolini, A., Picatoste Olloqui, E., Pietrzyk, B., Pilař, T., Pinci, D., Pistone, A., Playfer, S., Plo Casasus, M., Poikela, T., Polci, F., Poluektov, A., Polyakov, I., Polycarpo, E., Popov, A., Popov, D., Popovici, B., Potterat, C., Price, E., Price, J.D., Prisciandaro, J., Pritchard, A., Prouve, C., Pugatch, V., Puig Navarro, A., Punzi, G., Qian, W., Quagliani, R., Rachwal, B., Rademacker, J.H., Rakotomiaramanana, B., Rama, M., Rangel, M.S., Raniuk, I., Rauschmayr, N., Raven, G., Redi, F., Reichert, S., Reid, M.M., dos Reis, A.C., Ricciardi, S., Richards, S., Rihl, M., Rinnert, K., Rives Molina, V., Robbe, P., Rodrigues, A.B., Rodrigues, E., Rodriguez Lopez, J.A., Rodriguez Perez, P., Roiser, S., Romanovsky, V., Romero Vidal, A., Rotondo, M., Rouvinet, J., Ruf, T., Ruiz, H., Ruiz Valls, P., Saborido Silva, J.J., Sagidova, N., Sail, P., Saitta, B., Salustino Guimaraes, V., Sanchez Mayordomo, C., Sanmartin Sedes, B., Santacesaria, R., Santamarina Rios, C., Santovetti, E., Sarti, A., Satriano, C., Satta, A., Saunders, D.M., Savrina, D., Schiller, M., Schindler, H., Schlupp, M., Schmelling, M., Schmidt, B., Schneider, O., Schopper, A., Schune, M.H., Schwemmer, R., Sciascia, B., Sciubba, A., Semennikov, A., Sepp, I., Serra, N., Serrano, J., Sestini, L., Seyfert, P., Shapkin, M., Shapoval, I., Shcheglov, Y., Shears, T., Shekhtman, L., Shevchenko, V., Shires, A., Silva Coutinho, R., Simi, G., Sirendi, M., Skidmore, N., Skillicorn, I., Skwarnicki, T., Smith, N.A., Smith, E., Smith, J., Smith, M., Snoek, H., Sokoloff, M.D., Soler, F.J.P., Soomro, F., Souza, D., Souza De Paula, B., Spaan, B., Spradlin, P., Sridharan, S., Stagni, F., Stahl, M., Stahl, S., Steinkamp, O., Stenyakin, O., Sterpka, F., Stevenson, S., Stoica, S., Stone, S., Storaci, B., Stracka, S., Straticiuc, M., Straumann, U., Stroili, R., Sun, L., Sutcliffe, W., Swientek, K., Swientek, S., Syropoulos, V., Szczekowski, M., Szczypka, P., Szumlak, T., T'Jampens, S., Teklishyn, M., Tellarini, G., Teubert, F., Thomas, C., Thomas, E., van Tilburg, J., Tisserand, V., Tobin, M., Todd, J., Tolk, S., Tomassetti, L., Tonelli, D., Topp-Joergensen, S., Torr, N., Tournefier, E., Tourneur, S., Trabelsi, K., Tran, M.T., Tresch, M., Trisovic, A., Tsaregorodtsev, A., Tsopelas, P., Tuning, N., Ukleja, A., Ustyuzhanin, A., Uwer, U., Vacca, C., Vagnoni, V., Valenti, G., Vallier, A., Vazquez Gomez, R., Vazquez Regueiro, P., Vázquez Sierra, C., Vecchi, S., Velthuis, J.J., Veltri, M., Veneziano, G., Vesterinen, M., Viana Barbosa, J.V., Viaud, B., Vieira, D., Vieites Diaz, M., Vilasis-Cardona, X., Vollhardt, A., Volyanskyy, D., Voong, D., Vorobyev, A., Vorobyev, V., Voß, C., de Vries, J.A., Waldi, R., Wallace, C., Wallace, R., Walsh, J., Wandernoth, S., Wang, J., Ward, D.R., Watson, N.K., Websdale, D., Weiden, A., Whitehead, M., Wiedner, D., Wilkinson, G., Wilkinson, M., Williams, M., Williams, M.P., Wilson, F.F., Wimberley, J., Wishahi, J., Wislicki, W., Witek, M., Wormser, G., Wotton, S.A., Wright, S., Wyllie, K., Xie, Y., Xu, Z., Yang, Z., Yuan, X., Yushchenko, O., Zangoli, M., Zavertyaev, M., Zhang, L., Zhang, Y., Zhelezov, A., Zhokhov, A., and Zhong, L.

Abstract

Proton–proton collision data recorded in 2011 and 2012 by the LHCb experiment, corresponding to an integrated luminosity of 3.0 fb−1, are analysed to search for the charmless B0→ρ0ρ0 decay. More than 600 B0→(π+π−)(π+π−) signal decays are selected and used to perform an amplitude analysis, under the assumption of no CP violation in the decay, from which the B0→ρ0ρ0 decay is observed for the first time with 7.1 standard deviations significance. The fraction of B0→ρ0ρ0 decays yielding a longitudinally polarised final state is measured to be fL=0.745−0.058+0.048(stat)±0.034(syst). The B0→ρ0ρ0 branching fraction, using the B0→ϕK⁎(892)0 decay as reference, is also reported as B(B0→ρ0ρ0)=(0.94±0.17(stat)±0.09(syst)±0.06(BF))×10−6.

Published
2015

243. PBRM1: A Critical Subunit of the SWI/SNF Chromatin Remodeling Complex

Author

Chung-Han Lee, James J. Hsieh, and Can G. Pham

Subjects
BAP1, medicine, Cancer, Genomics, Computational biology, Biology, Carcinogenesis, medicine.disease_cause, medicine.disease, Chromatin remodeling, Exome sequencing, SWI/SNF, PBRM1
Abstract

Rapid advances in genomics have altered the landscape of oncology by accelerating the identification of disease-related oncogenes and tumor suppressors. It has become increasingly evident that even within specific cancer types there is incredible genetic diversity and heterogeneity, which may help explain the variability of responses to therapy. Greater understanding of these genetic changes will help the development of personalized, targeted care for patients. Large-scale sequencing projects, surveying whole exomes of clear cell renal cell carcinoma (ccRCC) tumors, have recently identified several important tumor suppressor genes, including PBRM1, SETD2, BAP1, and KDM5C. These genes are guiding new directions for oncology research and providing intriguing insights into ccRCC tumorigenesis. Specifically, the identification of these genes has heightened interest over discovering clinically useful kidney cancer biomarkers. Also, they have triggered intensive efforts in basic science laboratories to elucidate the biological function behind each enigmatic gene, with a view toward refining paradigms that more accurately reflect ccRCC formation and disease progression, and for developing better strategies for patient care.

Published
2014

245. EBV miRNAs BART11 and BART17-3p promote immune escape through the enhancer-mediated transcription of PD-L1

Author

Jie Wang, Junshang Ge, Yian Wang, Fang Xiong, Jiayue Guo, Xianjie Jiang, Lishen Zhang, Xiangying Deng, Zhaojian Gong, Shanshan Zhang, Qijia Yan, Yi He, Xiayu Li, Lei Shi, Can Guo, Fuyan Wang, Zheng Li, Ming Zhou, Bo Xiang, Yong Li, Wei Xiong, and Zhaoyang Zeng

Subjects
Science
Abstract

Epstein-Barr virus (EBV)-encoded latent genes are reported to regulate PD-L1 expression to promote immune escape. Here, the authors show that EBV-encoded miRNAs EBV-miR-BART11 and EBV-miR-BART17-3p upregulate PD-L1 expression in nasopharyngeal carcinoma and gastric cancer by targeting FOXP1 and PBRM1.

Published
2022
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246. Splicing factor derived circular RNA circCAMSAP1 accelerates nasopharyngeal carcinoma tumorigenesis via a SERPINH1/c-Myc positive feedback loop

Author

Yian Wang, Qijia Yan, Yongzhen Mo, Yuhang Liu, Yumin Wang, Shanshan Zhang, Can Guo, Fuyan Wang, Guiyuan Li, Zhaoyang Zeng, and Wei Xiong

Subjects
Nasopharyngeal carcinoma, circCAMSAP1, SERPINH1, c-Myc, SRSF10, Proliferation, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Circular RNAs play an important role in tumor genesis and progression, but they have not been sufficiently studied in patients with nasopharyngeal carcinoma (NPC). Methods The circular RNA, circCAMSAP1, was screened in NPC cells by RNA sequencing analysis. The expression of circCAMSAP1 in NPC tissues was examined by real-time quantitative polymerase chain reaction (RT-qPCR) and in situ hybridization. Wound-healing, transwell, MTT and flow cytometry assays, and nude mouse tumor models were used to explore the effect of circCAMSAP1 on proliferation and metastasis of NPC in vitro or in vivo. The downstream proteins regulated by circCAMSAP1 were screened using mass spectrometry. The interaction between circCAMSAP1 and the SERPINH1 mRNA was identified using the circular RNA immunoprecipitation method and the luciferase reporter assay. The interaction between SERPINH1 and transcription factor c-Myc was verified through Co-immunoprecipitation (Co-IP) and immunofluorescence. The effect of c-Myc on the generation of circCAMSAP1 was examined through RT-qPCR and chromatin immunoprecipitation. Finally, the splicing factors that promote the production of circCAMSAP1 were explored by RT-qPCR and RNA immunoprecipitation (RIP). Results We found that circCAMSAP1 was highly expressed in NPC tissues and promoted NPC proliferation and metastasis. Additionally, circCAMSAP1 promoted SERPINH1 expression through improved SERPINH1 mRNA stability by binding to the 3′-untranslated region (3’UTR) of SERPINH1. Highly expressed SERPINH1 reduced the ubiquitination-degradation rate of c-Myc, causing increased tumorigenesis. Meanwhile, c-Myc, cooperating with splicing factor 10 (SRSF10), could also promote CAMSAP1 pre-mRNA transcription and back-splicing, forming a positive feedback of circCAMSAP1 production, resulting in the proliferation and metastasis of NPC. Conclusions Our findings revealed that circCAMSAP1 promotes NPC proliferation and metastasis by binding to the 3’UTR of SERPINH1, suggesting that the positive feedback of circCAMSAP1-SERPINH1-c-Myc may serve as a prognostic biomarker or therapeutic target in patients with NPC.

Published
2022
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247. Effect of harvest time on the chemical composition and antioxidant capacity of Gannan navel orange (Citrus sinensis L. Osbeck ‘Newhall’ juice

Author

Jun ZHANG, Jing-yi ZHANG, You-xia SHAN, Can GUO, Lian HE, Lin-yan ZHANG, Wei LING, Yan LIANG, and Ba-lian ZHONG

Subjects
navel orange, antioxidant, harvest time, chemical composition, Agriculture (General), S1-972
Abstract

The present study investigates the chemical composition and antioxidant capacity of juice from the Gannan navel orange, which is harvested at one- to two-week intervals during the ripening period. The total soluble solid (TSS), total polyphenol content (TPC), total flavonoid content (TFC), sucrose and hesperidin contents gradually increase with the ripening of the fruit, followed by slight declines at the late maturity stage. Contrary to these observations, the contents of titratable acid (TA), vitamin C (Vc), and limonin trend downward throughout the ripening period. However, the contents of fructose, glucose, and narirutin fluctuate throughout the harvest time. Three in vitro antioxidant assays consistently indicate that the harvest time exerts no significant influence (P>0.01) on the antioxidant capacity. Furthermore, principal component analysis (PCA) and Pearson's correlation test are performed to provide an overview of the complete dataset. This study provides valuable information for evaluating the fruit quality and determining when to harvest the fruit in order to meet the preferences of consumers. Meanwhile, our observations suggest that the fruits subjected to juice processing should be harvested at the late maturity stage to alleviate the “delayed bitterness” problem without compromising the antioxidant capacity and the flavonoid content in the juice.

Published
2022
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248. In the Crosshairs: NF-κB Targets the JNK Signaling Cascade

Author

Concetta Bubici, Can G. Pham, Salvatore Papa, Guido Franzoso, and Francesca Zazzeroni

Subjects
Pharmacology, chemistry.chemical_classification, Reactive oxygen species, Programmed cell death, medicine.medical_treatment, Immunology, NF-κB, Biology, Proinflammatory cytokine, XIAP, Cell biology, chemistry.chemical_compound, Cytokine, chemistry, Downregulation and upregulation, medicine, Immunology and Allergy, Transcription factor
Abstract

NF-κB/Rel transcription factors are well-known for their roles in the regulation of inflammation and immunity. NF-κB also blocks programmed cell death (PCD) or apoptosis triggered by proinflammatory cytokine, tumor necrosis factor (TNF)α. Through transcriptional induction of distinct subsets of cyto-protective target genes, NF-κB inhibits the execution of apoptosis activated by this cytokine. This protective action is mediated, in part, by factors (such as A20, GADD45β, and XIAP) that downregulate the pro-apoptotic c-Jun-N-terminal (JNK) pathway. A suppression of reactive oxygen species (ROS), which are themselves major cell death-inducing elements activated by TNFα, is an additional protective function recently ascribed to NF-κB. This function of NF-κB involves an induction of mitochondrial anti-oxidant enzyme, manganese superoxide dismutase (Mn-SOD), and a control of cellular iron availability through upregulation of Ferritin heavy chain - one of two subunits of Ferritin, the major iron storage protein complex of the cell. An emerging view of NF-κB is that, while integrated, its actions in immunity and in promoting cell survival are executed through upregulation of distinct subsets of target genes. Thus, these inducible blockers of apoptosis may provide potential new targets to inhibit specific functions of NF-κB. In the future, this might allow for a better treatment of complex human diseases involving dysregulated NF-κB activity, including chronic inflammatory conditions and cancer.

Published
2005

249. NF-κB meets ROS: an ‘iron-ic’ encounter

Author

Salvatore Papa, Can G. Pham, Guido Franzoso, Concetta Bubici, and Francesca Zazzeroni

Subjects
chemistry.chemical_classification, Oxidative damage, Reactive oxygen species, chemistry.chemical_compound, chemistry, chemistry.chemical_element, NF-κB, Cell Biology, Biology, Molecular Biology, Oxygen, Potential toxicity, Cell biology
Abstract

Since becoming abundant in the atmosphere approximately 2.3 billion years ago, oxygen has been a defining element for life on our planet. One needs not be a biologist to know the importance of oxygen for sustaining life – termed in fact 'aerobic' life. Our body is built around the need to maximize exploitation of oxygen for the production of energy. The respiratory and cardiovascular systems are exemplary illustrations of this need. Like all good things, however, oxygen can also be extremely harmful. Its original accumulation on Earth caused the extinction of most existing life forms, defenseless against oxidative damage. Even a layperson is aware of this potential toxicity of oxygen. Indeed, nowadays antioxidants are among the most heavily advertised dietary supplements on the market. Yet, it would surprise most to know that the potent reactivity of oxygen and its products – so-called reactive oxygen species (ROS) – is purposefully used by nature to transduce signals that actively trigger cell suicide or programmed cell death (PCD), as well as other biological responses.

Published
2005

250. Worldwide trends in diabetes since 1980: A pooled analysis of 751 population-based studies with 4.4 million participants

Author

Zhou, B. (Bin), Lu, Y. (Yuan), Hajifathalian, K. (Kaveh), Bentham, J. (James), Di Cesare, M. (Mariachiara), Danaei, G. (Goodarz), Bixby, H. (Honor), Cowan, M.J. (Melanie J.), Ali, M.K. (Mohammed), Taddei, C. (Cristina), Lo, W.-C. (Wei-Cheng), Reis-Santos, B. (Barbara), Stevens, G.A. (Gretchen A.), Riley, L.M. (Leanne M.), Miranda, J.J. (J. Jaime), Bjerregaard, P. (Peter), Rivera, J.A. (Juan A.), Fouad, H.M. (Heba M.), Ma, G. (Guansheng), Mbanya, J.C.N. (Jean Claude N.), McGarvey, S.T. (Stephen T.), Mohan, V. (Viswanathan), Onat, A. (Altan), Pilav, A. (Aida), Ramachandran, A. (Ambady), Ben Romdhane, H. (Habiba), Paciorek, C.J. (Christopher J.), Bennett, J.E. (James E.), Ezzati, M. (Majid), Abdeen, Z.A. (Ziad A.), Kadir, K.A. (Khalid Abdul), Abu-Rmeileh, N.M. (Niveen M.), Acosta-Cazares, B. (Benjamin), Adams, R. (Robert), Aekplakorn, W. (Wichai), Aguilar-Salinas, C.A. (Carlos), Agyemang, C.O. (Charles), Ahmadvand, A. (Alireza), Al-Othman, A.R. (Amani Rashed), Alkerwi, A. (Ala'a), Amouyel, P. (Philippe), Amuzu, A. (Antoinette), Bo Andersen, L. (Lars), Anderssen, S.A. (Sigmund A.), Anjana, R.M. (Ranjit Mohan), Aounallah-Skhiri, H. (Hajer), Aris, T. (Tahir), Arlappa, N. (Nimmathota), Arveiler, D. (Dominique), Assah, F.K. (Felix K.), Avdicová, M. (Mária), Azizi, J. (Joshan), Balakrishna, N. (Nagalla), Bandosz, P. (Piotr), Barbagallo, C.M. (Carlo M.), Barceló, A. (Alberto), Batieha, A.M. (Anwar M.), Baur, L.A. (Louise A.), Benet, M. (Mikhail), Bernabe-Ortiz, A. (Antonio), Bharadwaj, S. (Sumit), Bhargava, S.K. (Santosh K.), Bi, Y. (Yufang), Bjertness, E. (Espen), Bjertness, M.B. (Marius B.), Björkelund, C. (Cecilia), Blokstra, A. (Anneke), Bo, S. (Simona), Boehm, B.O. (Bernhard), Boissonnet, C.P. (Carlos P.), Bovet, P. (Pascal), Brajkovich, I. (Imperia), Breckenkamp, J. (Juergen), Brenner, H. (Hermann), Brewster, L.M. (Lizzy), Brian, G.R. (Garry R.), Bruno, G. (Graziella), Bugge, A. (Anna), De León, A.C. (Antonio Cabrera), Can, G. (Günay), Cåndido, A.P.C. (Ana Paula C.), Capuano, V. (Vincenzo), Carlsson, A.C. (Axel C.), Carvalho, M.J. (Maria J.), Casanueva, F.F. (Felipe F.), Casas, J.P. (Juan Pablo), Caserta, C.A. (Carmelo A.), Castetbon, K., Chamukuttan, S. (Snehalatha), Chaturvedi, N. (Nishi), Chen, C.-J. (Chien-Jen), Chen, F. (Fangfang), Chen, S. (Shuohua), Cheng, C.-Y. (Ching-Yu), Chetrit, A. (Angela), Chiou, S.-T. (Shu-Ti), Cho, Y. (Yumi), Chudek, J. (Jerzy), Cifkova, R. (Renata), Claessens, F., Concin, H. (Hans), Cooper, C. (Charles), Cooper, R. (Rachel), Costanzo, S. (Simona), Cottel, D. (Dominique), Cowell, C. (Chris), Crujeiras, A.B. (Ana B.), D'Arrigo, G. (Graziella), Dallongeville, J., Dankner, R. (Rachel), Dauchet, L. (Luc), De Gaetano, G. (Giovanni), De Henauw, S. (Stefaan), Deepa, M. (Mohan), Dehghan, A. (Abbas), Deschamps, V. (Valerie), Dhana, K. (Klodian), Di Castelnuovo, A.F. (Augusto F.), Djalalinia, S. (Shirin), Doua, K. (Kouamelan), Drygas, W. (Wojciech), Du, Y. (Yong), Dzerve, V. (Vilnis), Egbagbe, E.E. (Eruke E.), Eggertsen, R. (Robert), El Ati, J. (Jalila), Elosua, R. (Roberto), Erasmus, R.T. (Rajiv T.), Erem, C. (Cihangir), Ergor, G. (Gul), Eriksen, L. (Louise), Escobedo-De La Peña, J. (Jorge), Fall, C.H. (Caroline H.), Farzadfar, F. (Farshad), Felix-Redondo, F.J. (Francisco J.), Ferguson, T.S. (Trevor S.), Fernández-Bergés, D. (Daniel), Ferrari, M. (Marika), Ferreccio, C. (Catterina), Feskens, E.J.M. (Edith), Finn, J.D. (Joseph D.), Föger, B. (Bernhard), Foo, L.H. (Leng Huat), Forslund, A.-S. (Ann-Sofie), Francis, D.K. (Damian K.), Do Carmo Franco, M. (Maria), Franco, O.H. (Oscar), Frontera, G. (Guillermo), Furusawa, T. (Takuro), Gaciong, Z. (Zbigniew), Garnett, S.P. (Sarah P.), Gaspoz, J.-M. (Jean-Michel), Gasull, M. (Magda), Gates, L. (Louise), Geleijnse, J.M. (Marianne), Ghasemian, A. (Anoosheh), Ghimire, A. (Anup), Giampaoli, S. (Simona), Gianfagna, F. (Francesco), Giovannelli, J. (Jonathan), Giwercman, A. (Aleksander), Gross, M., Rivas, J.P.G. (Juan P. González), Gorbea, M.B. (Mariano Bonet), Gottrand, F. (Frederic), Grafnetter, D. (Dušan), Grodzicki, T. (Tomasz), Grøntved, A. (Anders), Gruden, G. (Grabriella), Gu, D. (Dongfeng), Guan, O.P. (Ong Peng), Guerrero, R. (Ramiro), Guessous, I. (Idris), Guimaraes, A.L. (Andre L.), Gutierrez, L. (Laura), Hambleton, I.R. (Ian R.), Hardy, R., Kumar, R.H. (Rachakulla Hari), Hata, J. (Jun), He, J. (Jiang), Heidemann, C. (Christin), Herrala, S. (Sauli), Hihtaniemi, I.T. (Ilpo Tapani), Ho, S.Y. (Sai Yin), Ho, S.C. (Suzanne C.), Hofman, A. (Albert), Hormiga, C.M. (Claudia M.), Horta, B.L. (Bernardo L.), Houti, L. (Leila), Howitt, C. (Christina), Htay, T.T. (Thein Thein), Htet, A.S. (Aung Soe), Htike, M.M.T. (Maung Maung Than), Hu, Y. (Yang), Hussieni, A.S. (Abdullatif S.), Huybrechts, I. (Inge), Hwalla, N. (Nahla), Iacoviello, L. (Licia), Iannone, A.G. (Anna G.), Ibrahim, M.M. (M. Mohsen), Ikeda, N. (Nayu), Ikram, M.A. (M. Arfan), Irazola, V. (Vilma), Islam, M. (Muhammad), Iwasaki, M. (Masanori), Jacobs, J.M. (Jeremy M.), Jafar, T.H. (Tazeen), Jamil, K.M. (Kazi M.), Jasienska, G. (Grazyna), Jiang, C.Q. (Chao Qiang), Jonas, J.B., Joshi, P. (Pradeep), Kafatos, A. (Anthony), Kalter-Leibovici, O. (Ofra), Kasaeian, A. (Amir), Katz, J. (Joanne), Kaur, P. (Prabhdeep), Kavousi, M. (Maryam), Keinanen-Kiukaanniemi, S. (Sirkka), Kelishadi, R. (Roya), Kengne, A.P. (Andre Pascal), Kersting, M. (Mathilde), Khader, Y.S. (Yousef Saleh), Khalili, D. (Davood), Khang, Y.-H. (Young-Ho), Kiechl, S. (Stefan), Kim, J. (Jeongseon), Kolsteren, P. (Patrick), Korrovits, P. (Paul), Kratzer, W. (Wolfgang), Kromhout, D. (Daan), Kujala, U.M. (Urho), Kula, K. (Krzysztof), Kyobutungi, C. (Catherine), Laatikainen, T. (Tiina), Lachat, C. (Carl), Laid, Y. (Youcef), Lam, T.H. (Tai Hing), Landrove, O. (Orlando), Lanska, V. (Vera), Lappas, G. (Georg), Laxmaiah, A. (Avula), Leclercq, C. (Catherine), Lee, J. (Jeannette), Lee, J. (Jeonghee), Lehtimäki, T. (Terho), Lekhraj, R. (Rampal), León-Muñoz, L.M. (Luz M.), Li, Y. (Yanping), Lim, W.-Y. (Wei-Yen), Lima-Costa, M.F. (M. Fernanda), Lin, H.-H. (Hsien-Ho), Lin, X. (Xu), Lissner, L. (Lauren), Lorbeer, R. (Roberto), Lozano, J.E. (José Eugenio), Luksiene, D. (Dalia), Lundqvist, A. (Annamari), Lytsy, P. (Per), Machado-Coelho, G.L.L. (George L.L.), Machi, S. (Suka), Maggi, S. (Stefania), Magliano, D.J., Makdisse, M. (Marcia), Rao, K.M. (Kodavanti Mallikharjuna), Manios, Y., Manzato, E. (Enzo), Margozzini, P. (Paula), Marques-Vidal, P. (Pedro), Martorell, R. (Reynaldo), Masoodi, S.R. (Shariq R.), Mathiesen, E.B. (Ellisiv), Matsha, T.E. (Tandi E.), McFarlane, S.R. (Shelly R.), McLachlan, S. (Stela), McNulty, B.A. (Breige A.), Mediene-Benchekor, S. (Sounnia), Meirhaeghe, A. (Aline), Menezes, A.M.B. (Ana Maria B.), Merat, S. (Shahin), Meshram, I.I. (Indrapal I.), Mi, J. (Jie), Miquel, J.F. (Juan Francisco), Mohamed, M.K. (Mostafa K.), Mohammad, K. (Kazem), Mohammadifard, N. (Noushin), Mohd Yusoff, M.F. (Muhammad Fadhli), Møller, N.C. (Niels C.), Molnár, D. (Dénes), Mondo, C.K. (Charles K.), Morejon, A. (Alain), Moreno, L.A. (Luis A.), Morgan, K. (Karen), Moschonis, G., Mossakowska, M. (Malgorzata), Mostafa, A. (Aya), Mota, J. (Jorge), Motta, J. (Jorge), Mu, T.T. (Thet Thet), Muiesan, M.L. (Maria Lorenza), Müller-Nurasyid, M. (Martina), Mursu, J. (Jaakko), Nagel, G. (Gabriele), Námešná, J. (Jana), Nang, E.E.K. (Ei Ei K.), Nangia, M. (Monika), Navarrete-Muñoz, E.M., Ndiaye, N.C. (Ndeye Coumba), Nenko, I. (Ilona), Nervi, F. (Flavio), Nguyen, N.D. (Nguyen D.), Nguyen, Q.N. (Quang Ngoc), Nieto-Martínez, R.E. (Ramfis E.), Ning, G. (Guang), Ninomiya, T. (Toshiharu), Noale, M. (Marianna), Noto, D. (Davide), Al Nsour, M. (Mohannad), Ochoa-Avilés, A.M. (Angélica M.), Oh, K. (Kyungwon), Ordunez, P. (Pedro), Osmond, C. (Clive), Otero, J.A. (Johanna A.), Owusu-Dabo, E. (Ellis), Pahomova, E. (Elena), Palmieri, L. (Luigi), Panda-Jonas, S. (Songhomitra), Panza, F. (Francesco), Parsaeian, M. (Mahboubeh), Peixoto, S.V. (Sergio Viana), Peltonen, M. (Markku), Peters, A., Peykari, N. (Niloofar), Pham, S.T. (Son Thai), Pitakaka, F. (Freda), Piwonska, A. (Aleksandra), Piwonski, J. (Jerzy), Plans-Rubió, P. (Pedro), Porta, M., Portegies, M.L.P. (Marileen), Poustchi, H. (Hossein), Pradeepa, R. (Rajendra), Price, J.F. (Jackie F.), Punab, M. (Margus), Qasrawi, R.F. (Radwan F.), Qorbani, M. (Mostafa), Radisauskas, R. (Ricardas), Rahman, M. (Mahmudur), Raitakari, O. (Olli), Rao, S.R. (Sudha Ramachandra), Ramke, J. (Jacqueline), Ramos, R. (Rafel), Rampal, S. (Sanjay), Rathmann, W. (Wolfgang), Redón, J. (Josep), Reganit, P.F.M. (Paul Ferdinand M.), Rigo, F. (Fernando), Robinson, S.M. (Siân), Robitaille, C. (Cynthia), Rodríguez Artalejo, F. (Fernando), Del CristoRodriguez-Perez, M. (María), Rodríguez-Villamizar, L.A. (Laura A.), Rojas-Martinez, R. (Rosalba), Ronkainen, K. (Kimmo), Rosengren, A. (Annika), Rubinstein, A. (Adolfo), Rui, O. (Ornelas), Ruiz-Betancourt, B.S. (Blanca Sandra), Horimoto, A.R.V.R. (Andrea R.V. Russo), Rutkowski, M. (Marcin), Sabanayagam, C. (Charumathi), Sachdev, H.S. (Harshpal S.), Saidi, O. (Olfa), Sakarya, S. (Sibel), Salanave, B. (Benoit), Salonen, J.T. (Jukka T.), Salvetti, M. (Massimo), Sánchez-Abanto, J. (Jose), Santos, D. (Diana), Dos Santos, R.N. (Renata Nunes), Santos, R. (Rute), Saramies, J. (Jouko), Sardinha, L.B. (Luis B.), Sarrafzadegan, N. (Nizal), Saum, K.-U. (Kai-Uwe), Scazufca, M. (Marcia), Schargrodsky, H. (Herman), Scheidt-Nave, C. (C.), Sein, A.A. (Aye Aye), Sharma, S.K. (Sanjb K.), Shaw, J.E., Shibuya, K. (Kenji), Shin, Y. (Youchan), Shiri, R. (Rahman), Siantar, R. (Rosalynn), Sibai, A.M. (Abla M.), Simon, M. (Mary), Simons, J. (Judith), Simons, L.A. (Leon A.), Sjostrom, M. (Michael), Slowikowska-Hilczer, J. (Jolanta), Slusarczyk, P. (Przemyslaw), Smeeth, L. (Liam), Snijder, M.B. (Marieke), So, H.-K. (Hung-Kwan), Sobngwi, E. (Eugène), Söderberg, S. (Stefan), Solfrizzi, V. (Vincenzo), Sonestedt, E. (Emily), Soumare, A. (Aicha), Staessen, J.A. (Jan A.), Stathopoulou, M.G. (Maria G.), Steene-Johannessen, J. (Jostein), Stehle, P. (Peter), Stein, A.D. (Aryeh D.), Stessman, J. (Jochanan), Stöckl, D. (Doris), Stokwiszewski, J. (Jakub), Stronks, K. (Karien), Strufaldi, M.W. (Maria Wany), Sun, C.-A. (Chien-An), Sundstrom, J. (Johan), Sung, Y.-T. (Yn-Tz), Suriyawongpaisal, P. (Paibul), Sy, R.G. (Rody G.), Tai, E.S. (E. Shyong), Tamosiunas, A. (Abdonas), Tang, L. (Line), Tarawneh, M. (Mohammed), Tarqui-Mamani, C.B. (Carolina B), Taylor, A. (Anne), Theobald, H. (Holger), Thijs, L. (Lutgarde), Thuesen, L. (Leif), Tolonen, H.K. (Hanna K.), Tolstrup, J.S. (Janne S.), Topbas, M. (Murat), Torrent, M. (Maties), Traissac, P. (Pierre), Trinh, O.T.H. (Oanh T.H.), Tulloch-Reid, M.K. (Marshall K.), Tuomainen, T.-P. (Tomi-Pekka), Turley, M.L. (Maria L.), Tzourio, C. (Christophe), Ueda, P. (Peter), Ukoli, F.A.M. (Flora A.M.), Ulmer, H. (Hanno), Uusitalo, H.M.T. (Hannu M.T.), Valdivia, G. (Gonzalo), Valvi, D. (Damaskini), Rossem, L. (Lenie) van, Valkengoed, I. (Irene) van, Vanderschueren, D. (Dirk), Vanuzzo, D. (Diego), Vega, T. (Tomas), Velasquez-Melendez, G. (Gustavo), Veronesi, G. (Giovanni), Verschuren, W.M.M. (W.M. Monique), Verstraeten, R. (Roosmarijn), Viet, L. (Lucie), Vioque, J. (Jesus), Virtanen, J.K. (Jyrki K.), Visvikis-Siest, S. (Sophie), Viswanathan, B. (Bharathi), Vollenweider, P. (Peter), Voutilainen, S. (Sari), Vrijheid, M. (Martine), Wade, A.N. (Alisha N.), Wagner, A. (Aline), Walton, J. (Janette), Wan Mohamud, W.N. (Wan Nazaimoon), Wang, F. (Feng), Wang, M.-D. (Ming-Dong), Wang, Q. (Qian), Wang, Y. (Ying), Wannamethee, S.G. (Goya), Weerasekera, D. (Deepa), Whincup, P.H. (Peter), Widhalm, K. (Kurt), Wiecek, A. (Andrzej), Wijga, A.H. (Alet), Wilks, R.J. (Rainford J.), Willeit, J. (Johann), Wilsgaard, T. (Tom), Wojtyniak, B. (Bogdan), Wong, T.Y. (Tien Yin), Woo, J. (Jean), Woodward, M. (Mark), Wu, F.C. (Frederick C.), Wu, S.L. (Shou Ling), Xu, H. (Haiquan), Yan, W. (Weili), Yang, X. (Xiaoguang), Ye, X. (Xingwang), Yoshihara, A. (Akihiro), Younger-Coleman, N.O. (Novie O.), Zambon, S. (Sabina), Zargar, A.H. (Abdul Hamid), Zdrojewski, T. (T.), Zhao, W. (Wenhua), Zheng, Y. (Yingfeng), Cisneros, J.Z. (Julio Zuñiga), Zhou, B. (Bin), Lu, Y. (Yuan), Hajifathalian, K. (Kaveh), Bentham, J. (James), Di Cesare, M. (Mariachiara), Danaei, G. (Goodarz), Bixby, H. (Honor), Cowan, M.J. (Melanie J.), Ali, M.K. (Mohammed), Taddei, C. (Cristina), Lo, W.-C. (Wei-Cheng), Reis-Santos, B. (Barbara), Stevens, G.A. (Gretchen A.), Riley, L.M. (Leanne M.), Miranda, J.J. (J. Jaime), Bjerregaard, P. (Peter), Rivera, J.A. (Juan A.), Fouad, H.M. (Heba M.), Ma, G. (Guansheng), Mbanya, J.C.N. (Jean Claude N.), McGarvey, S.T. (Stephen T.), Mohan, V. (Viswanathan), Onat, A. (Altan), Pilav, A. (Aida), Ramachandran, A. (Ambady), Ben Romdhane, H. (Habiba), Paciorek, C.J. (Christopher J.), Bennett, J.E. (James E.), Ezzati, M. (Majid), Abdeen, Z.A. (Ziad A.), Kadir, K.A. (Khalid Abdul), Abu-Rmeileh, N.M. (Niveen M.), Acosta-Cazares, B. (Benjamin), Adams, R. (Robert), Aekplakorn, W. (Wichai), Aguilar-Salinas, C.A. (Carlos), Agyemang, C.O. (Charles), Ahmadvand, A. (Alireza), Al-Othman, A.R. (Amani Rashed), Alkerwi, A. (Ala'a), Amouyel, P. (Philippe), Amuzu, A. (Antoinette), Bo Andersen, L. (Lars), Anderssen, S.A. (Sigmund A.), Anjana, R.M. (Ranjit Mohan), Aounallah-Skhiri, H. (Hajer), Aris, T. (Tahir), Arlappa, N. (Nimmathota), Arveiler, D. (Dominique), Assah, F.K. (Felix K.), Avdicová, M. (Mária), Azizi, J. (Joshan), Balakrishna, N. (Nagalla), Bandosz, P. (Piotr), Barbagallo, C.M. (Carlo M.), Barceló, A. (Alberto), Batieha, A.M. (Anwar M.), Baur, L.A. (Louise A.), Benet, M. (Mikhail), Bernabe-Ortiz, A. (Antonio), Bharadwaj, S. (Sumit), Bhargava, S.K. (Santosh K.), Bi, Y. (Yufang), Bjertness, E. (Espen), Bjertness, M.B. (Marius B.), Björkelund, C. (Cecilia), Blokstra, A. (Anneke), Bo, S. (Simona), Boehm, B.O. (Bernhard), Boissonnet, C.P. (Carlos P.), Bovet, P. (Pascal), Brajkovich, I. (Imperia), Breckenkamp, J. (Juergen), Brenner, H. (Hermann), Brewster, L.M. (Lizzy), Brian, G.R. (Garry R.), Bruno, G. (Graziella), Bugge, A. (Anna), De León, A.C. (Antonio Cabrera), Can, G. (Günay), Cåndido, A.P.C. (Ana Paula C.), Capuano, V. (Vincenzo), Carlsson, A.C. (Axel C.), Carvalho, M.J. (Maria J.), Casanueva, F.F. (Felipe F.), Casas, J.P. (Juan Pablo), Caserta, C.A. (Carmelo A.), Castetbon, K., Chamukuttan, S. (Snehalatha), Chaturvedi, N. (Nishi), Chen, C.-J. (Chien-Jen), Chen, F. (Fangfang), Chen, S. (Shuohua), Cheng, C.-Y. (Ching-Yu), Chetrit, A. (Angela), Chiou, S.-T. (Shu-Ti), Cho, Y. (Yumi), Chudek, J. (Jerzy), Cifkova, R. (Renata), Claessens, F., Concin, H. (Hans), Cooper, C. (Charles), Cooper, R. (Rachel), Costanzo, S. (Simona), Cottel, D. (Dominique), Cowell, C. (Chris), Crujeiras, A.B. (Ana B.), D'Arrigo, G. (Graziella), Dallongeville, J., Dankner, R. (Rachel), Dauchet, L. (Luc), De Gaetano, G. (Giovanni), De Henauw, S. (Stefaan), Deepa, M. (Mohan), Dehghan, A. (Abbas), Deschamps, V. (Valerie), Dhana, K. (Klodian), Di Castelnuovo, A.F. (Augusto F.), Djalalinia, S. (Shirin), Doua, K. (Kouamelan), Drygas, W. (Wojciech), Du, Y. (Yong), Dzerve, V. (Vilnis), Egbagbe, E.E. (Eruke E.), Eggertsen, R. (Robert), El Ati, J. (Jalila), Elosua, R. (Roberto), Erasmus, R.T. (Rajiv T.), Erem, C. (Cihangir), Ergor, G. (Gul), Eriksen, L. (Louise), Escobedo-De La Peña, J. (Jorge), Fall, C.H. (Caroline H.), Farzadfar, F. (Farshad), Felix-Redondo, F.J. (Francisco J.), Ferguson, T.S. (Trevor S.), Fernández-Bergés, D. (Daniel), Ferrari, M. (Marika), Ferreccio, C. (Catterina), Feskens, E.J.M. (Edith), Finn, J.D. (Joseph D.), Föger, B. (Bernhard), Foo, L.H. (Leng Huat), Forslund, A.-S. (Ann-Sofie), Francis, D.K. (Damian K.), Do Carmo Franco, M. (Maria), Franco, O.H. (Oscar), Frontera, G. (Guillermo), Furusawa, T. (Takuro), Gaciong, Z. (Zbigniew), Garnett, S.P. (Sarah P.), Gaspoz, J.-M. (Jean-Michel), Gasull, M. (Magda), Gates, L. (Louise), Geleijnse, J.M. (Marianne), Ghasemian, A. (Anoosheh), Ghimire, A. (Anup), Giampaoli, S. (Simona), Gianfagna, F. (Francesco), Giovannelli, J. (Jonathan), Giwercman, A. (Aleksander), Gross, M., Rivas, J.P.G. (Juan P. González), Gorbea, M.B. (Mariano Bonet), Gottrand, F. (Frederic), Grafnetter, D. (Dušan), Grodzicki, T. (Tomasz), Grøntved, A. (Anders), Gruden, G. (Grabriella), Gu, D. (Dongfeng), Guan, O.P. (Ong Peng), Guerrero, R. (Ramiro), Guessous, I. (Idris), Guimaraes, A.L. (Andre L.), Gutierrez, L. (Laura), Hambleton, I.R. (Ian R.), Hardy, R., Kumar, R.H. (Rachakulla Hari), Hata, J. (Jun), He, J. (Jiang), Heidemann, C. (Christin), Herrala, S. (Sauli), Hihtaniemi, I.T. (Ilpo Tapani), Ho, S.Y. (Sai Yin), Ho, S.C. (Suzanne C.), Hofman, A. (Albert), Hormiga, C.M. (Claudia M.), Horta, B.L. (Bernardo L.), Houti, L. (Leila), Howitt, C. (Christina), Htay, T.T. (Thein Thein), Htet, A.S. (Aung Soe), Htike, M.M.T. (Maung Maung Than), Hu, Y. (Yang), Hussieni, A.S. (Abdullatif S.), Huybrechts, I. (Inge), Hwalla, N. (Nahla), Iacoviello, L. (Licia), Iannone, A.G. (Anna G.), Ibrahim, M.M. (M. Mohsen), Ikeda, N. (Nayu), Ikram, M.A. (M. Arfan), Irazola, V. (Vilma), Islam, M. (Muhammad), Iwasaki, M. (Masanori), Jacobs, J.M. (Jeremy M.), Jafar, T.H. (Tazeen), Jamil, K.M. (Kazi M.), Jasienska, G. (Grazyna), Jiang, C.Q. (Chao Qiang), Jonas, J.B., Joshi, P. (Pradeep), Kafatos, A. (Anthony), Kalter-Leibovici, O. (Ofra), Kasaeian, A. (Amir), Katz, J. (Joanne), Kaur, P. (Prabhdeep), Kavousi, M. (Maryam), Keinanen-Kiukaanniemi, S. (Sirkka), Kelishadi, R. (Roya), Kengne, A.P. (Andre Pascal), Kersting, M. (Mathilde), Khader, Y.S. (Yousef Saleh), Khalili, D. (Davood), Khang, Y.-H. (Young-Ho), Kiechl, S. (Stefan), Kim, J. (Jeongseon), Kolsteren, P. (Patrick), Korrovits, P. (Paul), Kratzer, W. (Wolfgang), Kromhout, D. (Daan), Kujala, U.M. (Urho), Kula, K. (Krzysztof), Kyobutungi, C. (Catherine), Laatikainen, T. (Tiina), Lachat, C. (Carl), Laid, Y. 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Abstract

Background: One of the global targets for non-communicable diseases is to halt, by 2025, the rise in the age standardised adult prevalence of diabetes at its 2010 levels. We aimed to estimate worldwide trends in diabetes, how likely it is for countries to achieve the global target, and how changes in prevalence, together with population growth and ageing, are aff ecting the number of adults with diabetes. Methods: We pooled data from population-based studies that had collected data on diabetes through measurement of its biomarkers. We used a Bayesian hierarchical model to estimate trends in diabetes prevalence-defined as fasting plasma glucose of 7.0 mmol/L or higher, or history of diagnosis with diabetes, or use of insulin or oral hypoglycaemic drugs-in 200 countries and territories in 21 regions, by sex and from 1980 to 2014. We also calculated the posterior probability of meeting the global diabetes target if post-2000 trends continue. Findings: We used data from 751 studies including 4372000 adults from 146 of the 200 countries we make estimates for. Global age-standardised diabetes prevalence increased from 4.3% (95% credible interval 2.4-17.0) in 1980 to 9.0% (7.2-11.1) in 2014 in

Published
2016
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