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202. Shpol'skii spectroscopy of metabolites of polycyclic aromatic hydrocarbons in primary alcohols at 77 K and 4.2 K

Author

Chehelamirani, Mohammadreza, Wang, Huiyong, Santana, Anthony, and Campiglia, Andrés D.

Abstract

We present for the first time experimental evidence on the line-narrowing effect caused by primary alcohols on the spectral features of metabolites of polycyclic aromatic hydrocarbons at 77 K and 4.2 K. The investigated metabolites include 1-hydroxypyrene, 2-hydroxyfluorene, 9-hydroxyphenanthrene, 3-hydroxybenzo[a]pyrene, 4-hydroxybenzo[a]pyrene, 5-hydroxybenzo[a]pyrene, B[a]P-trans-7,8-dihydrodiol (±), B[a]P-trans-9,10-dihydrodiol (±), B[a]P-r-7,t-8-dihydrodiol-c-9,10-epoxide (±) and B[a]P-r-7,t-8-dihydrodiol-t-9,10-epoxide(±). The narrowest spectra and highest fluorescence enhancements were observed by matching the length of the alcohol to the length of the n-alkane that best fits the molecular dimensions of the parent polycyclic aromatic hydrocarbons. The analytical figures of merit show potential for the qualitative and quantitative analysis of PAH metabolites viaShpol'skii Spectroscopy.

Published
2020
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203. Novel Potent Decameric Peptide of Spirulina platensis Reduces Blood Pressure Levels Through a PI3K/AKT/eNOS-Dependent Mechanism.

Author

Carrizzo, Albino, Damato, Antonio, Ambrosio, Mariateresa, De Lucia, Massimiliano, Madonna, Michele, Campiglia, Pietro, Vecchione, Carmine, Sciarretta, Sebastiano, Frati, Giacomo, Sommella, Eduardo, Sala, Marina, Scala, Maria Carmina, Aquino, Rita Patrizia, Sansone, Francesca, Conte, Giulio Maria, Ostacolo, Carmine, Capunzo, Mario, and Migliarino, Serena

Abstract

Considered as a superfood of the future, Spirulina platensis matrix has been extensively used because of its beneficial effect on the management of cardiovascular diseases. However, its nutraceutical properties, bioactive compounds, and molecular mechanisms are unknown. Here, we demonstrate that S platensis matrix processed in vitro by simulated gastrointestinal digestion induces direct endothelial nitric oxide (NO)-mediated vasorelaxation of resistance vessels in mice. To gain insight into the bioactive compounds responsible for this effect, we used a complex multistep peptidomic approach to fractionate the crude digest: of the 5 peptide fractions identified (A-E), only fraction E evoked vasorelaxation. High-resolution mass spectrometry-based screening revealed in E the presence of 4 main peptides (SP3-SP6 [spirulina peptides]), of which only SP6 (GIVAGDVTPI) exerted direct endothelium-dependent vasodilation of ex vivo vessels, an effect occurring via a PI3K (phosphoinositide-3-kinase)/AKT (serine/threonine kinase Akt) pathway converging on NO release. In vivo, administration of SP6 evoked a significant hemodynamic effect, reducing blood pressure, an action absent in eNOS (endothelial NO synthase)-deficient mice. Of note, although lower doses of SP6 had no hemodynamic effects, it still enhanced endothelial NO vasorelaxation. Finally, in an experimental model of arterial hypertension, SP6 exerted an antihypertensive effect, improving endothelial vasorelaxation associated with enhanced serum nitrite levels. Based on our results, this novel decameric peptide may extend the possible fields of application for spirulina-derived peptides and could be developed into a promising nonpharmacological approach for the containment of pathologies associated with vascular NO misregulation. [ABSTRACT FROM AUTHOR]

Published
2019
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204. Identification of the Spiro(oxindole-3,3′-thiazolidine)-Based Derivatives as Potential p53 Activity Modulators

Author

Gomez-Monterrey, Isabel, Bertamino, Alessia, Porta, Amalia, Carotenuto, Alfonso, Musella, Simona, Aquino, Claudio, Granata, Ilaria, Sala, Marina, Brancaccio, Diego, Picone, Delia, Ercole, Carmine, Stiuso, Paola, Campiglia, Pietro, Grieco, Paolo, Ianelli, Pio, Maresca, Bruno, and Novellino, Ettore

Abstract

Here, we report the design of new analogues of spirooxoindolepyrrolidine nucleus as modulators of p53 activity. Compounds (3R,7aR)-6-(4-chlorobenzyl)-1H-spiro[imidazo[1,5-c]thiazole-3,3′-indoline]-2′,5,7(6H,7aH)-trione (9c) and (3R,7aR)-5′-methyl-6-(3,4,5-trimethoxybenzyl)-1H-spiro[imidazo[1,5-c]thiazole-3,3′-indoline]-2′,5,7(6H,7aH)-trione (10d) are the most potent compounds of this series, inhibiting cell growth of different human tumor cells at submicromolar and micromolar concentrations, respectively. Compound 9cinduces apoptotic cell death in human melanoma cell line M14 at 24 h, while in the same condition, treatment with 10dshowes a clear arrest at G2/M phase inducing delay of cell cycle progression. Possibly, these activities may be due to inhibition of p53−MDM2 interaction and subsequent p53 release and activation.

Published
2024
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205. A Comprehensive In VitroCharacterization of a New Class of Indole-Based Compounds Developed as Selective Haspin Inhibitors

Author

Vestuto, Vincenzo, Ciaglia, Tania, Musella, Simona, Di Sarno, Veronica, Smaldone, Gerardina, Di Matteo, Francesca, Scala, Maria Carmina, Napolitano, Valeria, Miranda, Maria Rosaria, Amodio, Giuseppina, Novi, Sara, Pepe, Giacomo, Basilicata, Manuela Giovanna, Gazzillo, Erica, Pace, Simona, Gomez-Monterrey, Isabel M., Sala, Marina, Bifulco, Giuseppe, Tecce, Mario Felice, Campiglia, Pietro, Ostacolo, Carmine, Lauro, Gianluigi, Manfra, Michele, and Bertamino, Alessia

Abstract

Haspin is an emerging, but rather unexplored, divergent kinase involved in tumor growth by regulating the mitotic phase. In this paper, the in-silicodesign, synthesis, and biological characterization of a new series of substituted indoles acting as potent Haspin inhibitors are reported. The synthesized derivatives have been evaluated by FRET analysis, showing very potent Haspin inhibition. Then, a comprehensive in-cell investigation highlighted compounds 47and 60as the most promising inhibitors. These compounds were challenged for their synergic activity with paclitaxel in 2D and 3D cellular models, demonstrating a twofold improvement of the paclitaxel antitumor activity. Compound 60also showed remarkable selectivity when tested in a panel of 70 diverse kinases. Finally, in-silicostudies provided new insight about the chemical requirements useful to develop new Haspin inhibitors. Biological results, together with the drug-likeness profile of 47and 60, make these derivatives deserving further studies.

Published
2024
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206. In SilicoAssisted Identification, Synthesis, and In VitroPharmacological Characterization of Potent and Selective Blockers of the Epilepsy-Associated KCNT1 Channel

Author

Iraci, Nunzio, Carotenuto, Lidia, Ciaglia, Tania, Belperio, Giorgio, Di Matteo, Francesca, Mosca, Ilaria, Carleo, Giusy, Giovanna Basilicata, Manuela, Ambrosino, Paolo, Turcio, Rita, Puzo, Deborah, Pepe, Giacomo, Gomez-Monterrey, Isabel, Soldovieri, Maria Virginia, Di Sarno, Veronica, Campiglia, Pietro, Miceli, Francesco, Bertamino, Alessia, Ostacolo, Carmine, and Taglialatela, Maurizio

Abstract

Gain-of-function (GoF) variants in KCNT1 channels cause severe, drug-resistant forms of epilepsy. Quinidine is a known KCNT1 blocker, but its clinical use is limited due to severe drawbacks. To identify novel KCNT1 blockers, a homology model of human KCNT1 was built and used to screen an in-house library of compounds. Among the 20 molecules selected, five (CPK4, 13, 16, 18, and 20) showed strong KCNT1-blocking ability in an in vitrofluorescence-based assay. Patch-clamp experiments confirmed a higher KCNT1-blocking potency of these compounds when compared to quinidine, and their selectivity for KCNT1 over hERG and Kv7.2 channels. Among identified molecules, CPK20displayed the highest metabolic stability; this compound also blocked KCNT2 currents, although with a lower potency, and counteracted GoF effects prompted by 2 recurrent epilepsy-causing KCNT1 variants (G288S and A934T). The present results provide solid rational basis for future design of novel compounds to counteract KCNT1-related neurological disorders.

Published
2024
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207. Antioxidant Profile and in Vitro Cardiac Radical-Scavenging versus Pro-oxidant Effects of Commercial Red Grape Juices ( Vitis vinifera L. cv. Aglianico N.)

Author

Tenore GC, Manfra M, Coppola L, Russo M, Gomez Monterrey IM, Campiglia P., STIUSO, Paola, Tenore, Gc, Manfra, M, Stiuso, Paola, Coppola, L, Russo, M, Gomez Monterrey, Im, and Campiglia, P.

Abstract

Several works have reported on the pharmaceutical usefulness of grape phytochemicals. Nevertheless, the scientific literature needs further studies to consider grape extracts as useful dietary supplements. The aim of the present work was to hypothesize for the first time the use of whole commercial red grape juices as food supplements potentially useful against both physiological and induced cardiac oxidative stress. First of all, the results indicated a good antioxidant stability of the juice sample to lyophilization that may be reasonably regarded as a suitable process for the formulation of food supplements. Then, the processed sample (lioRGJ) was tested on cardiac-derived H9C2 myocytes to ascertain its effects on reactive oxygen species (ROS) generation and caspase-3 activity incubating cardiomyocytes with lioRGJ at increasing doses (0.01-1 μg). Experiments showed an appreciable direct radical-scavenging activity at a maximum sample dose of 0.01 μg that made the caspase-3 activity decrease by about 47% (P < 0.001). Cardiac cells were exposed to 1 μM doxorubicin and its combination with different doses of lioRGJ. A maximum sample aliquot of 0.01 μg seemed to effectively contrast the induced oxidant injury, decreasing the ROS levels by about 31% and depressing the caspase-3 activity by about 60% (P < 0.001). In both assays, pro-oxidant effects at higher sample concentrations were detected as indicated by the increase in both ROS generation and apoptotic activity. The data suggested the possible employment of the juice sample as a food supplement with prospective cardioprotective benefits, although further studies are needed to optimize its dosages to avoid harmful pro-oxidant effects.

Published
2012

208. DESIGN AND SYNTHESIS OF N-METHYL DERIVATIVES OF UROTENSIN-II

Author

MERLINO, FRANCESCO, DI MARO, SALVATORE, YOUSIF, ALI MUNAIM, Campiglia P., Meini S., Santicioli P., Maggi C. A., NOVELLINO, ETTORE, GRIECO, PAOLO, Kokotos G., Cordopatis P., Merlino, Francesco, DI MARO, Salvatore, Yousif, ALI MUNAIM, Campiglia, P., Meini, S., Santicioli, P., Maggi, C. A., Novellino, Ettore, and Grieco, Paolo

Subjects
Urotensin II, METHYLATION, Peptide Synthesi
Abstract

Human Urotensin-II is an undecapeptide (hUT-II, H-Glu-Thr-Pro-Asp-[Cys-Phe-Trp-Lys-Tyr-Cys]-Val-OH) which was identified as a potent vasoconstrictor that binds with high affinity to UT receptor. The cysteine-linked cyclic region, hUT-II(4-11), is responsible for the biological activity and has been widely used to elucidate the Structure-Activity Relationship of hUT-II. With the aim to investigate the role of hydrogen bond and the effects of a peptide backbone constraint on binding affinity and biological activity, we have designed and synthesized new analogues by multiple N-Methylation of hUT-II(4-11) backbone amide bonds. All the peptides were performed by a novel synthetic approach, in which the introduction of N-methyl groups occur during regular solid-phase peptide synthesis. On these new ligands we evaluated the binding affinity and biological activity at the UT receptor and performed preliminary NMR conformational studies.

Published
2012

213. Peptides from Royal Jelly: studies on the antimicrobial activity of jelleins, jelleins analogs and synergy with temporins

Author

ROMANELLI, ALESSANDRA, IANNACCONE, MARCO, PEDONE, CARLO, CAPPARELLI, ROSANNA, Moggio L., Montella R. C., Campiglia P., Capuano F., Romanelli, Alessandra, Moggio, L., Montella, R. C., Campiglia, P., Iannaccone, Marco, Capuano, F., Pedone, Carlo, and Capparelli, Rosanna

Subjects
jellein, antimicrobial, temporins, royal jelly
Abstract

Peptides isolated from natural fonts are the object of several studies aimed at finding new molecules possessing antibacterial activity. We focused our studies on peptides originally isolated from the Royal Jelly, the jelleins and on some analogs having a UV reporter at the N- or C-terminus. We found that jelleins are mainly active against gram-positive bacteria; interestingly, they act in synergy with peptides belonging to the family of temporins such as temporin A and temporin B against Staphylococcus aureus A170 and Listeria monocytogenes.

Published
2011

214. Alanine scanning analysis and structure-function relationships of the frog-skin antimicrobial peptide temporin-1Ta

Author

GRIECO, PAOLO, CAROTENUTO, ALFONSO, NOVELLINO, ETTORE, Luca V., Auriemma L., Saviello M. R., Campiglia P., Barra D., Mangoni M. L., Grieco, Paolo, Luca, V., Auriemma, L., Carotenuto, Alfonso, Saviello, M. R., Campiglia, P., Barra, D., Novellino, Ettore, and Mangoni, M. L.

Subjects
antimicrobial peptide, temporin-1Ta
Abstract

The increasing resistance of bacteria and fungi to the available antibiotic/antimycotic drugs urges for a search for new anti-infective compounds with new modes of action. In line of this, natural CAMPs represent promising and attractive candidates. Special attention has been devoted to frog-skin temporins, because of their short size (10-14 residues long) and their unique features. In particular, temporin-1Ta has the following properties: (i) it is mainly active on Gram-positive bacteria; (ii) it can synergize, when combined with temporin-1Tl, in inhibiting both gram-negative bacterial growth and the toxic effect of LPS; (iii) it preserves biological activity in the presence of serum; and (iv) it is practically not hemolytic. Rational design of CAMPs represents a straightforward approach to obtain a peptide with a better therapeutic index. Here, we used alanine scanning analogs to elucidate the contribution of the side chains of each amino acid residue to the peptide's antimicrobial and hemolytic activity. Beside providing insight into the biophysical attributes and the critical positions within the peptide sequence, which govern the antimicrobial/hemolytic activity of this temporin isoform, our studies assist in optimizing the design of temporin-based lead structures for the production of new anti-infective agents. Copyright © 2011 European Peptide Society and John Wiley & Sons, Ltd

Published
2011

215. Microwave-assisted synthesis of KN-93, a potent and selective inhibitor of Ca2+/calmoduline-dependent protein kinase II

Author

Bruno C., Lentini G., Catalano A., Carocci A., Lovece A., Di Mola A., Cavalluzzi M. M., Tortorella P., Loiodice F., Iaccarino G., Campiglia P., Novellino E., Franchini C., Bruno, C., Lentini, G., Catalano, A., Carocci, A., Lovece, A., Di Mola, A., Cavalluzzi, M. M., Tortorella, P., Loiodice, F., Iaccarino, G., Campiglia, P., Novellino, E., and Franchini, C.

Subjects
enzyme, Heck reaction, multicomponent reaction, medicinal chemistry, sulfonamides
Abstract

Convenient synthetic routes to KN-93, N-(2-{[[(2E)-3-(4-chlorophenyl)prop- 2-enyl](methyl)amino]methyl}phenyl)-N-(2-hydroxyethyl)-4- methoxybenzenesulfonamide, a well-known Ca2+/calmoduline-dependent protein kinase II (CaMKII) inhibitor, are described. The methods proposed start from easily available reagents- and allow ready preparation of the final compound in moderate- overall yields. Most of the synthetic steps proposed were microwave assisted. © 2010 Georg Thieme Verlag Stuttgart, New York.

Published
2010

218. P5U and urantide modifi ed at position 7 with TPI

Author

Auriemma L., Campiglia P., Monterrey Gomez I., Santicioli P., Maggi C. A., Sala M., Rovero P., d'Emmanuele diVilla Bianca R., CAROTENUTO, ALFONSO, NOVELLINO, ETTORE, SORRENTINO, RAFFAELLA, GRIECO, PAOLO, Auriemma, L., Campiglia, P., Monterrey Gomez, I., Santicioli, P., Maggi, C. A., Sala, M., Rovero, P., Carotenuto, Alfonso, Novellino, Ettore, d'Emmanuele diVilla Bianca, R., Sorrentino, Raffaella, and Grieco, Paolo

Published
2008

220. Conformational analysis of the new temporin analogues: Gln3TA and Pro3TL

Author

Saviello M. R., Cavalli A., Malfi S., Campiglia P., Gomez Monterrey M. I., NOVELLINO, ETTORE, GRIECO, PAOLO, CAROTENUTO, ALFONSO, Saviello, M. R., Cavalli, A., Malfi, S., Campiglia, P., Gomez Monterrey, M. I., Novellino, Ettore, Grieco, Paolo, and Carotenuto, Alfonso

Published
2008

221. Design, synthesis and biological activities of temporin A and temporin L analogues

Author

L. Auriemma, Saviello M. R., Marcozzi C., Campiglia P., Gomez Monterrey M. I., Mangoni M. L., Malfi S., CAROTENUTO, ALFONSO, NOVELLINO, ETTORE, GRIECO, PAOLO, L., Auriemma, Saviello, M. R., Marcozzi, C., Carotenuto, Alfonso, Campiglia, P., Gomez Monterrey, M. I., Mangoni, M. L., Novellino, Ettore, Grieco, Paolo, and Malfi, S.

Published
2008

224. Poster session 1Cell growth, differentiation and stem cells - Heart72Understanding the metabolism of cardiac progenitor cells: a first step towards controlling their proliferation and differentiation?73Expression of pw1/peg3 identifies a new cardiac adult stem cell population involved in post-myocardial infarction remodeling74Long-term stimulation of iPS-derived cardiomyocytes using optogenetic techniques to promote phenotypic changes in E-C coupling75Benefits of electrical stimulation on differentiation and maturation of cardiomyocytes from human induced pluripotent stem cells76Constitutive beta-adrenoceptor-mediated cAMP production controls spontaneous automaticity of human induced pluripotent stem cell-derived cardiomyocytes77Formation and stability of T-tubules in cardiomyocytes78Identification of miRNAs promoting human cardiomyocyte proliferation by regulating Hippo pathway79A direct comparison of foetal to adult epicardial cell activation reveals distinct differences relevant for the post-injury response80Role of neuropilins in zebrafish heart regeneration81Highly efficient immunomagnetic purification of cardiomyocytes derived from human pluripotent stem cells82Cardiac progenitor cells posses a molecular circadian clock and display large 24-hour oscillations in proliferation and stress tolerance83Influence of sirolimus and everolimus on bone marrow-derived mesenchymal stem cell biology84Endoglin is important for epicardial behaviour following cardiac injuryCell death and apoptosis - Heart87Ultrastructural alterations reflecting Ca2+ handling and cell-to-cell coupling disorders precede occurrence of severe arrhythmias in intact animal heart88Urocortin-1 promotes cardioprotection through ERK1/2 and EPAC pathways: role in apoptosis and necrosis89Expression p38 MAPK and Cas-3 in myocardium LV of rats with experimental heart failure at melatonin and enalapril introductionTranscriptional control and RNA species - Heart92Accumulation of beta-amyloid 1-40 in HF patients: the role of lncRNA BACE1-AS93Role of miR-182 in zebrafish and mouse models of Holt-Oram syndrome94Mir-27 distinctly regulates muscle-enriched transcription factors and growth factors in cardiac and skeletal muscle cells95AF risk factors impair PITX2 expression leading to Wnt-microRNA-ion channel remodelingCytokines and cellular inflammation - Heart98Post-infarct survival depends on the interplay of monocytes, neutrophils and interferon gamma in a mouse model of myocardial Infarction99Inflammatory cd11b/c cells play a protective role in compensated cardiac hypertrophy by promoting an orai3-related pro-survival signal100Anti-inflammatory effects of endothelin receptor blockade in the atrial tissue of spontaneously hypertensive rats101Mesenchymal stromal cells reduce NLRP3 inflammasome activity in Coxsackievirus B3-induced myocarditis102Mesenchymal stromal cells modulate monocytes trafficking in Coxsackievirus B3-induced myocarditis103The impact of regulatory T lymphocytes on long-term mortality in patients with chronic heart failure104Temporal dynamics of dendritic cells after ST-elevation myocardial infarction relate with improvement of myocardial functionGrowth factors and neurohormones - Heart107Preconditioning of hypertrophied heart: miR-1 and IGF-1 crosstalk108Modulation of catecholamine secretion from human adrenal chromaffin cells by manipulation of G protein-coupled receptor kinase-2 activity109Evaluation of cyclic adenosin-3,5- monophosphate and neurohormones in patients with chronic heart failureNitric oxide and reactive oxygen species - Heart112Hydrogen sulfide donor inhibits oxidative and nitrosative stress, cardiohemodynamics disturbances and restores cNOS coupling in old rats113Role and mechanisms of action of aldehydes produced by monoamine oxidase A in cardiomyocyte death and heart failure114Exercise training has contrasting effects in myocardial infarction and pressure-overload due to different endothelial nitric oxide synthase regulation115S-Nitroso Human Serum Albumin dose-dependently leads to vasodilation and alters reactive hyperaemia in coronary arteries of an isolated mouse heart model116Modulating endothelial nitric oxide synthase with folic acid attenuates doxorubicin-induced cardiomyopathy119Effects of long-term very high intensity exercise on aortic structure and function in an animal model120Electron paramagnetic resonance spectroscopy quantification of nitrosylated hemoglobin (HbNO) as an index of vascular nitric oxide bioavailability in vivo121Deletion of repressor activator protein 1 impairs acetylcholine-induced relaxation due to production of reactive oxygen speciesExtracellular matrix and fibrosis - Heart124MicroRNA-19b is associated with myocardial collagen cross-linking in patients with severe aortic stenosis. Potential usefulness as a circulating biomarker125A new ex vivo model to study cardiac fibrosis126Heterogeneity of fibrosis and fibroblast differentiation in the left ventricle after myocardial infarction127Effect of carbohydrate metabolism degree compensation to the level of galectin-3 changes in hypertensive patients with chronic heart failure and type 2 diabetes mellitus128Statin paradox in association with calcification of bicuspid aortic valve interstitial cells129Cardiac function remains impaired despite reversible cardiac fibrosis after healed experimental viral myocarditisIon channels, ion exchangers and cellular electrophysiology - Heart132Identifying a novel role for PMCA1 (Atp2b1) in heart rhythm instability133Mutations of the caveolin-3 gene as a predisposing factor for cardiac arrhythmias134The human sinoatrial node action potential: time for a computational model135iPSC-derived cardiomyocytes as a model to dissect ion current alterations of genetic atrial fibrillation136Postextrasystolic potentiation in healthy and diseased hearts: effects of the site of origin and coupling interval of the preceding extrasystole137Absence of Nav1.8-based (late) sodium current in rabbit cardiomyocytes and human iPSC-CMs138hiPSC-derived cardiomyocytes from Brugada Syndrome patients without identified mutations do not exhibit cellular electrophysiological abnormalitiesMicrocirculation141Atherogenic indices, collagen type IV turnover and the development of microvascular complications- study in diabetics with arterial hypertension142Changes in the microvasculature and blood viscosity in women with rheumatoid arthritis, hypercholesterolemia and hypertensionAtherosclerosis145Shear stress regulates endothelial autophagy: consequences on endothelial senescence and atherogenesis146Obstructive sleep apnea causes aortic remodeling in a chronic murine model147Aortic perivascular adipose tissue displays an aged phenotype in early and late atherosclerosis in ApoE-/- mice148A systematic evaluation of the cellular innate immune response during the process of human atherosclerosis149Inhibition of Coagulation factor Xa increases plaque stability and attenuates the onset and progression of atherosclerotic plaque in apolipoprotein e-deficient mice150Regulatory CD4+ T cells from patients with atherosclerosis display pro-inflammatory skewing and enhanced suppression function151Hypoxia-inducible factor (HIF)-1alpha regulates macrophage energy metabolism by mediating miRNAs152Extracellular S100A4 is a key player of smooth muscle cell phenotypic transition: implications in atherosclerosis153Microparticles of healthy origins improve atherosclerosis-associated endothelial progenitor cell dysfunction via microRNA transfer154Arterial remodeling and metabolism impairment in early atherosclerosis155Role of pannexin1 in atherosclerotic plaque formationCalcium fluxes and excitation-contraction coupling158Amphiphysin II induces tubule formation in cardiac cells159Interleukin 1 beta regulation of connexin 43 in cardiac fibroblasts and the effects of adult cardiac myocyte:fibroblast co-culture on myocyte contraction160T-tubular electrical defects contribute to blunted beta-adrenergic response in heart failure161Beat-to-beat variability of intracellular Ca2+ dynamics of Purkinje cells in the infarct border zone of the mouse heart revealed by rapid-scanning confocal microscopy162The efficacy of late sodium current blockers in hypertrophic cardiomyopathy is dependent on genotype: a study on transgenic mouse models with different mutations163Synthesis of cADPR and NAADP by intracellular CD38 in heart: role in inotropic and arrhythmogenic effects of beta-adrenoceptor signalingContractile apparatus166Towards an engineered heart tissue model of HCM using hiPSC expressing the ACTC E99K mutation167Diastolic mechanical load delays structural and functional deterioration of ultrathin adult heart slices in culture168Structural investigation of the cardiac troponin complex by molecular dynamics169Exercise training restores myocardial and oxidative skeletal muscle function from myocardial infarction heart failure ratsOxygen sensing, ischaemia and reperfusion172A novel antibody specific to full-length stromal derived factor-1 alpha reveals that remote conditioning induces its cleavage by endothelial dipeptidyl peptidase 4173Attenuation of myocardial and vascular arginase activity by vagal nerve stimulation via a mechanism involving alpha-7 nicotinic receptor during cardiac ischemia and reperfusion174Novel nanoparticle-mediated medicine for myocardial ischemia-reperfusion injury simultaneously targeting mitochondrial injury and myocardial inflammation175Acetylcholine plays a key role in myocardial ischaemic preconditioning via recruitment of intrinsic cardiac ganglia176The role of nitric oxide and VEGFR-2 signaling in post ischemic revascularization and muscle recovery in aged hypercholesterolemic mice177Efficacy of ischemic preconditioning to protect the human myocardium: the role of clinical conditions and treatmentsCardiomyopathies and fibrosis180Plakophilin-2 haploinsufficiency leads to impaired canonical Wnt signaling in ARVC patient181Improved technique for customized, easier, safer and more reliable transverse aortic arch banding and debanding in mice as a model of pressure overload hypertrophy182Late sodium current inhibitors for the treatment of inducible obstruction and diastolic dysfunction in hypertrophic cardiomyopathy: a study on human myocardium183Angiotensin II receptor antagonist fimasartan has protective role of left ventricular fibrosis and remodeling in the rat ischemic heart184Role of High-Mobility Group Box 1 (HMGB1) redox state on cardiac fibroblasts activities and heart function after myocardial infarction185Atrial remodeling in hypertrophic cardiomyopathy: insights from mouse models carrying different mutations in cTnT186Electrophysiological abnormalities in ventricular cardiomyocytes from a Maine Coon cat with hypertrophic cardiomyopathy: effects of ranolazine187ZBTB17 is a novel cardiomyopathy candidate gene and regulates autophagy in the heart188Inhibition of SRSF4 in cardiomyocytes induces left ventricular hypertrophy189Molecular characterization of a novel cardiomyopathy related desmin frame shift mutation190Autonomic characterisation of electro-mechanical remodeling in an in-vitro leporine model of heart failure191Modulation of Ca2+-regulatory function by three novel mutations in TNNI3 associated with severe infant restrictive cardiomyopathyAging194The aging impact on cardiac mesenchymal like stromal cells (S+P+)195Reversal of premature aging markers after bariatric surgery196Sex-associated differences in vascular remodeling during aging: role of renin-angiotensin system197Role of the receptor for advanced glycation end-products (RAGE) in age dependent left ventricle dysfunctionsGenetics and epigenetics200hsa-miR-21-5p as a key factor in aortic remodeling during aneurysm formation201Co-inheritance of mutations associated with arrhythmogenic and hypertrophic cardiomyopathy in two Italian families202Lamin a/c hot spot codon 190: form various amino acid substitutions to clinical effects203Treatment with aspirin and atorvastatin attenuate cardiac injury induced by rat chest irradiation: Implication of myocardial miR-1, miR-21, connexin-43 and PKCGenomics, proteomics, metabolomics, lipidomics and glycomics206Differential phosphorylation of desmin at serines 27 and 31 drives the accumulation of preamyloid oligomers in heart failure207Potential role of kinase Akt2 in the reduced recovery of type 2 diabetic hearts subjected to ischemia / reperfusion injury208A proteomics comparison of extracellular matrix remodelling in porcine coronary arteries upon stent implantationMetabolism, diabetes mellitus and obesity211Targeting grk2 as therapeutic strategy for cancer associated to diabetes212Effects of salbutamol on large arterial stiffness in patients with metabolic syndrome213Circulating microRNA-1 and microRNA-133a: potential biomarkers of myocardial steatosis in type 2 diabetes mellitus214Anti-inflammatory nutrigenomic effects of hydroxytyrosol in human adipocytes - protective mechanisms of mediterranean diets in obesity-related inflammation215Alterations in the metal content of different cardiac regions within a rat model of diabetic cardiomyopathyTissue engineering218A novel conductive patch for application in cardiac tissue engineering219Establishment of a simplified and improved workflow from neonatal heart dissociation to cardiomyocyte purification and characterization220Effects of flexible substrate on cardiomyocytes cell culture221Mechanical stretching on cardiac adipose progenitors upregulates sarcomere-related genes

Author

Andre, E, primary, Yaniz-Galende, E, primary, Hamilton, C, primary, Dusting, G J, primary, Hellen, N, primary, Poulet, CE, primary, Diez Cunado, M, primary, Smits, AM, primary, Lowe, V, primary, Eckardt, D, primary, Du Pre, B, primary, Sanz Ruiz, R, primary, Moerkamp, A T, primary, Tribulova, N, primary, Smani, T, primary, Liskova, Y V, primary, Greco, S, primary, Guzzolino, E, primary, Franco, D, primary, Lozano-Velasco, E, primary, Knorr, M, primary, Pavoine, C, primary, Bukowska, A, primary, Van Linthout, S, primary, Miteva, K, primary, Sulzgruber, P, primary, Latet, S C, primary, Portnychenko, A, primary, Cannavo, A, primary, Kamilova, U, primary, Sagach, VF, primary, Santin, Y, primary, Octavia, Y, primary, Haller, PM, primary, Rubies, C, primary, Dei Zotti, F, primary, Wong, KHK, primary, Gonzalez Miqueo, A, primary, Kruithof, BPT, primary, Kadur Nagaraju, C, primary, Shaposhnikova, Y, primary, Songia, P, primary, Lindner, D, primary, Wilson, C, primary, Benzoni, P, primary, Fabbri, A, primary, Campostrini, G, primary, Jorge, E, primary, Casini, S, primary, Mengarelli, I, primary, Nikolov, A, primary, Bublikov, DS, primary, Kheloufi, M, primary, Walker, R E, primary, Van Dijk, RA, primary, Posthuma, JJ, primary, Dumitriu, I E, primary, Karshovska, E, primary, Sakic, A, primary, Alexandru, N, primary, Martin-Lorenzo, M, primary, Molica, F, primary, Taylor, RF, primary, Mcarthur, L, primary, Crocini, C, primary, Matsuyama, T-A, primary, Mazzoni, L, primary, Lin, W K, primary, Owen, TJ, primary, Scigliano, M, primary, Sheehan, A, primary, Bezerra Gurgel, A R, primary, Bromage, DI, primary, Kiss, A, primary, Ikeda, G, primary, Pickard, J M J, primary, Wirth, G, primary, Casos, K, primary, Khudiakov, A, primary, Nistal, JF, primary, Ferrantini, C, primary, Park, S-J, primary, Di Maggio, S, primary, Gentile, F, primary, Dini, L, primary, Buyandelger, B, primary, Larrasa-Alonso, J, primary, Schirmer, I, primary, Chin, SH, primary, Cimiotti, D, primary, Martini, 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2016
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225. Poster session 2Morphogenetic mechanisms290MiR-133 regulates retinoic acid pathway during early cardiac chamber specification291Bmp2 regulates atrial differentiation through miR-130 during early heart looping formationDevelopmental genetics294Association of deletion allele of insertion/deletion polymorphism in alpha 2B adrenoceptor gene and hypertension with or without type 2 diabetes mellitus295Association of G1359A polymorphism of the endocannabinoid type 1 receptor (CNR1) with coronary artery disease (CAD) with type 2 diabetes mellitusCell growth, differentiation and stem cells - Vascular298Gamma-secretase inhibitor prevents proliferation and migration of ductus arteriosus smooth muscle cells: a role of Notch signaling in postnatal closure of ductus arteriosus299Mesenchymal stromal-like cells (MLCs) derived from induced pluripotent stem (iPS) cells: a promising therapeutic option to promote neovascularization300Sonic Hedgehog promotes mesenchymal stem cell differentiation to vascular smooth muscle cells in cardiovacsular disease301Proinflammatory cytokine secretion and epigenetic modification in endothelial cells treated LPS-GinfivalisCell death and apoptosis - Vascular304Mitophagy acts as a safeguard mechanism against human vascular smooth muscle cell apoptosis induced by atherogenic lipidsTranscriptional control and RNA species - Vascular307MicroRNA-34a role in vascular calcification308Local delivery of a miR-146a inhibitor utilizing a clinically applicable approach attenuates neointima formation after vascular injury309Long noncoding RNA landscape of hypoxic endothelial cells310Specific circulating microRNAs levels associate with hypertension, hyperglycemia and dysfunctional HDL in acute coronary syndrome patientsCytokines and cellular inflammation - Vascular313Phosphodiesterase5A up-regulation in vascular endothelium under pro-inflammatory conditions: a newly disclosed anti-inflammatory activity for the omega-3polyunsaturated aatty acid docosahexaenoic acid314Cardiovascular risk modifying with extra-low dose anticytokine drugs in rhematoid arthritis315Conversion of human M-CSF macrophages into foam cells reduces their proinflammatory responses to classical M1-polarizing activation316Lymphocytic myocarditis coincides with increased plaque inflammation and plaque hemorrhage in coronary arteries, facilitating myocardial infarction317Serum osteoprotegerin level predictsdeclined numerous of circulating endothelial- derived and mononuclear-derived progenitor cells in patients with metabolic syndromeGrowth factors and neurohormones - Vascular320Effect of gastrin-releasing peptide (GRP) on vascular inflammationSignal transduction - Heart323A new synthetic peptide regulates hypertrophy in vitro through means of the inhibition of nfkb324Inducible fibroblast-specific knockout of p38 alpha map kinase is cardioprotective in a mouse model of isoproterenol-induced cardiac hypertrophy325Regulation of beta-adrenoceptor-evoked inotropic responses by inhibitory G protein, adenylyl cyclase isoforms 5 and 6 and phosphodiesterases326Binding to RGS3 and stimulation of M2 muscarinic acetylcholine receptors modulates the substrate specificity of p190RhoGAP in cardiac myocytes327Cardiac regulation of post-translational modifications, parylation and deacetylation in LMNA dilated cardiomyopathy mouse model328Beta-adrenergic regulation of the b56delta/pp2a holoenzyme in cardiac myocytes through b56delta phosphorylation at serine 573Nitric oxide and reactive oxygen species - Vascular331Oxidative stress-induced miR-200c disrupts the regulatory loop among SIRT1, FOXO1 and eNOS332Antioxidant therapy prevents oxidative stress-induced endothelial dysfunction and Enhances Wound Healing333Morphological and biochemical characterization of red blood cell in coronary artery diseaseCytoskeleton and mechanotransduction - Heart336Novel myosin activator, JSH compounds, increased myocardial contractility without chronotropic effect in ratsExtracellular matrix and fibrosis - Vascular339Ablation of Toll-like receptor 9 causes cardiac rupture after myocardial infarction by attenuating proliferation and differentiation of cardiac fibroblasts340Altered vascular remodeling in the mouse hind limb ischemia model in Factor VII activating protease (FSAP) deficiencyVasculogenesis, angiogenesis and arteriogenesis343Pro-angiogenic effects of proly-hydroxylase inhibitors and their potential for use in a novel strategy of therapeutic angiogenesis for coronary total occlusion344Nrf2 drives angiogenesis in transcription-independent manner: new function of the master regulator of oxidative stress response345Angiogenic gene therapy, despite efficient vascular growth, is not able to improve muscle function in normoxic or chronically ischemic rabbit hindlimbs -role of capillary arterialization and shunting346Effect of PAR-1 inhibition on collateral vessel growth in the murine hind limb model347Quaking is a key regulator of endothelial cell differentiation, neovascularization and angiogenesis348"Emerging angiogenesis" in the chick chorioallantoic membrane (CAM). An in vivo study349Exosomes from cardiomyocyte progenitor cells and mesenchymal stem cells stimulate angiogenesis in vitro and in vivo via EMMPRINEndothelium352Reciprocal regulation of GRK2 and bradykinin receptor stimulation modulate Ca2+ intracellular level in endothelial cells353The roles of bone morphogenetic proteins 9 and 10 in endothelial inflammation and atherosclerosis354The contribution of GPR55 to the L-alpha-lysophosphatidylinositol-induced vasorelaxation in isolated human pulmonary arteries355The endothelial protective ACE inhibitor Zofenoprilat exerts anti-inflammatory activities through H2S production356A new class of glycomimetic drugs to prevent free fatty acid-induced endothelial dysfunction357Endothelial progenitor cells to apoptotic endothelial cell-derived microparticles ration differentiatesas preserved from reduced ejection fractionheart failure358Proosteogenic genes are activated in endothelial cells of patients with thoracic aortic aneurysm359Endothelin ETB receptors mediate relaxing responses to insulin in pericardial resistance arteries from patients with cardiovascular disease (CVD)Smooth muscle and pericytes362CX3CR1 positive myeloid cells regulate vascular smooth muscle tone by inducing calcium oscillations via activation of IP3 receptors363A novel function of PI3Kg on cAMP regulation, role in arterial wall hyperplasia through modulation of smooth muscle cells proliferation364NRP1 and NRP2 play important roles in the development of neointimal hyperplasia in vivo365Azithromycin induces autophagy in aortic smooth muscle cellsCoagulation, thrombosis and platelets368The real time in vivo evaluation of platelet-dependent aldosterone prothrombotic action in mice369Development of a method for in vivo detection of active thrombi in mice370The antiplatelet effects of structural analogs of the taurine chloramine371The influence of heparin anticoagulant drugs on functional state of human platelets372Regulation of platelet aggregation and adenosine diphosphate release by d dimer in acute coronary syndrome (in vitro study)Oxygen sensing, ischaemia and reperfusion375Sirtuin 5 mediates brain injury in a mouse model of cerebral ischemia-reperfusion376Abscisic acid: a new player in cardiomyocyte protection from ischaemia?377Protective effects of ultramicronized palmitoylethanolamide (PEA-um) in myocardial ischaemia and reperfusion injury in vivo378Identification of stem cell-derived cardiomyocytes using cardiac specific markers and additional testing of these cells in simulated ischemia/reperfusion system379Single-dose intravenous metformin treatment could afford significant protection of the injured rat kidney in an experimental model of ischemia-reperfusion380Cardiotoxicity of long acting muscarinic receptor antagonists used for chronic obstructive pulmonary disease381Dependence antioxidant potential on the concentration of amino acids382The impact of ischemia-reperfusion on physiological parameters,apoptosis and ultrastructure of rabbit myocardium with experimental aterosclerosisMitochondria and energetics385MicroRNA-1 dependent regulation of mitochondrial calcium uniporter (MCU) in normal and hypertrophied hearts386Mitochondrial homeostasis and cardioprotection: common targets for desmin and aB-crystallin387Overexpression of mitofusin-2 (Mfn2) and associated mitochondrial dysfunction in the diabetic heart388NO-dependent prevention of permeability transition pore (MPTP) opening by H2S and its regulation of Ca2+ accumulation in rat heart mitochondria389G protein coupled receptor kinase 2 (GRK2) is fundamental in recovering mitochondrial morphology and function after exposure to ionizing radiation (IR)Gender issues392Sex differences in pulmonary vascular control; focus on the nitric oxide pathwayAging395Heart failure with preserved ejection fraction develops when feeding western diet to senescence-accelerated mice396Cardiovascular markers as predictors of cognitive decline in elderly hypertensive patients397Changes in connexin43 in old rats with volume overload chronic heart failureGenetics and epigenetics400Calcium content in the aortic valve is associated with 1G>2G matrix metalloproteinase 1 polymorphism401Neuropeptide receptor gene s (NPSR1) polymorphism and sleep disturbances402Endothelin-1 gene Lys198Asn polymorphism in men with essential hypertension complicated and uncomplicated with chronic heart failure403Association of common polymorphisms of the lipoprotein lipase and pon1 genes with the metabolic syndrome in a sample of community participantsGenomics, proteomics, metabolomics, lipidomics and glycomics405Gene expression quantification using multiplexed color-coded probe pairs to determine RNA content in sporadic cardiac myxoma406Large-scale phosphorylation study of the type 2 diabetic heart subjected to ischemia / reperfusion injury407Transcriptome-based identification of new anti-inflammatory properties of the olive oil hydroxytyrosol in vascular endothelial cell under basal and proinflammatory conditions408Gene polymorphisms combinations and risk of myocardial infarctionComputer modelling, bioinformatics and big data411Comparison of the repolarization reserve in three state-of-the-art models of the human ventricular action potentialMetabolism, diabetes mellitus and obesity414Endothelial monocyte-activating polypeptide-II improves heart function in type -I Diabetes mellitus415Admission glucose level is independent predictor of impaired left ventricular function in patients with acute myocardial infarction: a two dimensional speckle-tracking echocardiography study416Association between biochemical markers of lipid profile and inflammatory reaction and stiffness of the vascular wall in hypertensive patients with abdominal obesity417Multiple common co-morbidities produce left ventricular diastolic dysfunction associated with coronary microvascular dysfunction, oxidative stress and myocardial stiffening418Investigating the cardiovascular effects of antiretroviral drugs in a lean and high fat/sucrose diet rat model of obesity419Statins in the treatment of non-alcoholic steatohepatitis (NASH). Our experience from a 2-year prospective study in Constanta County, Romania420Epicardial adipose tissue as a predictor of cardiovascular outcome in patients with ACS undergoing PCI?Arterial and pulmonary hypertension423Dependence between heart rhythm disorers and ID polymorphism of ACE gene in hypertensive patients424Molecular mechanisms underlying the beneficial effects of Urocortin 2 in pulmonary arterial hypertension425Inhibition of TGf-b axis and action of renin-angiotensin system in human ascending aorta aneurysms426Early signs of microcirculation and macrocirculation abnormalities in prehypertension427Vascular smooth muscle cell-expressed Tie-2 controls vascular tone428Cardiac and vascular remodelling in the development of chronic thrombo-embolic pulmonary hypertension in a novel swine modelBiomarkers431Arrhythmogenic cardiomyopathy: a new, non invasive biomarker432Can circulating microRNAs distinguish type 1 and type 2 myocardial infarction?433Design of a high-throughput multiplex proteomics assay to identify left ventricular diastolic dysfunction in diabetes434Monocyte-derived and P-selectin-carrying microparticles are differently modified by a low fat diet in patients with cardiovascular risk factors who will and who will not develop a cardiovascular event435Red blood cell distribution width assessment by polychromatic interference microscopy of thin films in chronic heart failure436Invasive and noninvasive evaluation of quality of radiofrequency-induced cardiac denervation in patients with atrial fibrillation437The effect of therapeutic hypothermia on the level of brain derived neurotrophic factor (BDNF) in sera following cardiopulmonary resustitation438Novel biomarkers to predict outcome in patients with heart failure and severe aortic stenosis439Biological factors linking depression and anxiety to cardiovascular disease440Troponins and myoglobin dynamic at coronary arteries graftingInvasive, non-invasive and molecular imaging443Diet composition effects on the genetic typing of the mouse ob mutation: a micro-ultrasound characterization of cardiac function, macro and micro circulation and liver steatosis444Characterization of pig coronary and rabbit aortic lesions using IV-OCT quantitative analysis: correlations with histologyGene therapy and cell therapy447Enhancing the survival and angiogenic potential of mouse atrial mesenchymal cells448VCAM-1 expression in experimental myocardial infarction and its relation to bone marrow-derived mononuclear cell retentionTissue engineering451Advanced multi layered scaffold that increases the maturity of stem cell-derived human cardiomyocytes452Response of engineered heart tissue to simulated ischemia/reperfusion in the presence of acute hyperglycemic conditions453Serum albumin hydrogels prevent de-differentiation of neonatal cardiomyocytes454A novel paintbrush technique for transfer of low viscosity ultraviolet light curable cyan methacrylate on saline immersed in-vitro sheep heart

Author

Garcia-Martinez, V, primary, Lopez Sanchez, C, primary, Hamed, W, primary, Hsu, JH, primary, Ferrer-Lorente, R, primary, Alshamrani, Maryam, primary, Pizzicannella, J, primary, Vindis, C, primary, Badi, I, primary, Korte, L, primary, Voellenkle, C, primary, Niculescu, L S, primary, Massaro, M, primary, Babaeva, AR, primary, Da Silva, F, primary, Woudstra, L, primary, Berezin, A, primary, Bae, MK, primary, Del Giudice, C, primary, Bageghni, S A, primary, Krobert, K, primary, Levay, M, primary, Vignier, N, primary, Ranieri, A, primary, Magenta, A, primary, Orlandi, A, primary, Porro, B, primary, Jeon, E-S, primary, Omori, Y, primary, Herold, J, primary, Barnett, G A, primary, Grochot-Przeczek, A, primary, Korpisalo, P, primary, Deffge, C, primary, Margariti, A, primary, Rong, W, primary, Maring, JA, primary, Gambardella, J, primary, Mitrofan, CG, primary, Karpinska, O, primary, Morbidelli, L, primary, Wilkinson, FL, primary, Kostina, AS, primary, De Mey, J G R, primary, Kumar, A, primary, Lupieri, A, primary, Pellet-Many, C, primary, Stamatiou, R, primary, Gromotowicz, A, primary, Dickhout, A, primary, Murina, M, primary, Roka-Moiia, YM, primary, Malinova, L, primary, Diaz-Canestro, C, primary, Vigliarolo, T, primary, Cuzzocrea, S, primary, Szantai, A, primary, Medic, B, primary, Cassambai, S, primary, Korda, A, primary, Revnic, C R, primary, Borile, G, primary, Diokmetzidou, A, primary, Murfitt, L, primary, Budko, A, primary, Fiordelisi, A, primary, De Wijs-Meijler, DPM, primary, Gevaert, AB, primary, Noriega De La Colina, A, primary, Benes, J, primary, Guillermo Solache Berrocal, GSB, primary, Gafarov, V, primary, Zhebel, VM, primary, Prakaschandra, R, primary, Stepien, E L, primary, Smith, LE, primary, Carluccio, MA, primary, Timasheva, Y, primary, Paci, M, primary, Dorofeyeva, N A, primary, Chimed, CH, primary, Petelina, TI, primary, Sorop, O, primary, Genis, A, primary, Parepa, I R, primary, Tscharre, M, primary, Krestjyaninov, MV, primary, Maia-Rocha, C, primary, Borges, L, primary, Sasonko, M L, primary, Kapel, SS, primary, Stam, K, primary, Sommariva, E, primary, Stojkovic, S, primary, O'reilly, J, primary, Chiva-Blanch, G, primary, Evtushenko, A, primary, Skopal, J, primary, Sunderland, N, primary, Gegenava, T, primary, Charnaia, MA, primary, Di Lascio, N, primary, Tarvainen, SJ, primary, Malandraki-Miller, S, primary, Uitterdijk, A, primary, Benzoni, P, primary, Ruivo, E, primary, Humphrey, E J, primary, Arokiaraj, MC, primary, Franco, D, additional, Garcia-Lopez, V, additional, Aranega, A, additional, Lopez-Sanchez, C, additional, Garcia-Martinez, V, additional, Tayel, S, additional, Khader, H, additional, El-Helbawy, N, additional, Alrefai, A, additional, El-Barbary, H, additional, Wu, JR, additional, Dai, ZK, additional, Yeh, JL, additional, Sanjurjo-Rodriguez, C, additional, Richaud-Patin, Y, additional, Blanco, FJ, additional, Badimon, L, additional, Raya, A, additional, Cahill, Paul A, additional, Diomede, F, additional, Merciaro, I, additional, Trubiani, O, additional, Nahapetyan, H, additional, Swiader, A, additional, Faccini, J, additional, Boya, P, additional, Elbaz, M, additional, Zeni, F, additional, Burba, I, additional, Bertolotti, M, additional, Capogrossi, MC, additional, Pompilio, G, additional, Raucci, A, additional, Widmer-Teske, R, additional, Dutzmann, J, additional, Bauersachs, J, additional, Donde, K, additional, Daniel, JM, additional, Sedding, DG, additional, Simionescu, N, additional, Sanda, GM, additional, Carnuta, MG, additional, Stancu, CS, additional, Popescu, AC, additional, Popescu, MR, additional, Vlad, A, additional, Dimulescu, DR, additional, Sima, AV, additional, Scoditti, E, additional, Pellegrino, M, additional, Calabriso, N, additional, Carluccio, MA, additional, Storelli, C, additional, De Caterina, R, additional, Solodenkova, KS, additional, Kalinina, EV, additional, Usachiova, MN, additional, Lappalainen, J, additional, Lee-Rueckert, M DE C, additional, Kovanen, PT, additional, Biesbroek, PS, additional, Emmens, RWE, additional, Van Rossum, AC, additional, Juffermans, LJM, additional, Niessen, JWM, additional, Krijnen, PAJ, additional, Kremzer, A, additional, Samura, T, additional, Berezina, T, additional, Gronenko, E, additional, Kim, MK, additional, Park, HJ, additional, Bae, SK, additional, Sorriento, D, additional, Ciccarelli, M, additional, Vernieri, E, additional, Campiglia, P, additional, Trimarco, B, additional, Iaccarino, G, additional, Hemmings, K E, additional, Porter, K E, additional, Ainscough, J F, additional, Drinkhill, M J, additional, Turner, N A, additional, Hiis, HG, additional, Cosson, MV, additional, Levy, FO, additional, Wieland, T, additional, Macquart, C, additional, Chatzifrangkeskou, M, additional, Evans, A, additional, Bonne, G, additional, Muchir, A, additional, Kemp, E, additional, Avkiran, M, additional, Carlomosti, F, additional, D'agostino, M, additional, Beji, S, additional, Zaccagnini, G, additional, Maimone, B, additional, Di Stefano, V, additional, De Santa, F, additional, Cordisco, S, additional, Antonini, A, additional, Ciarapica, R, additional, Dellambra, E, additional, Martelli, F, additional, Avitabile, D, additional, Scioli, MG, additional, Bielli, A, additional, Agostinelli, S, additional, Tarquini, C, additional, Tarallo, V, additional, De Falco, S, additional, Zaninoni, A, additional, Fiorelli, S, additional, Bianchi, P, additional, Teruzzi, G, additional, Squellerio, I, additional, Turnu, L, additional, Lualdi, A, additional, Tremoli, E, additional, Cavalca, V, additional, Lee, YJ, additional, Ju, ES, additional, Choi, JO, additional, Lee, GY, additional, Lim, BK, additional, Manickam, MANOJ, additional, Jung, S-H, additional, Omiya, S, additional, Otsu, K, additional, Deffge, C, additional, Nowak, S, additional, Wagner, M, additional, Braun-Dullaeus, RC, additional, Kostin, S, additional, Francke, A, additional, Subramaniam, S, additional, Kanse, SM, additional, Al-Lamee, K, additional, Schofield, CJ, additional, Egginton, S, additional, Gershlick, AH, additional, Kloska, D, additional, Kopacz, A, additional, Augustyniak, A, additional, Dulak, J, additional, Jozkowicz, A, additional, Hytonen, J, additional, Halonen, P, additional, Taavitsainen, J, additional, Tarvainen, S, additional, Hiltunen, T, additional, Liimatainen, T, additional, Kalliokoski, K, additional, Knuuti, J, additional, Yla-Herttuala, S, additional, Weinert, S, additional, Isermann, B, additional, Lee, J, additional, Herold, J, additional, Cochrane, A, additional, Kelaini, S, additional, Bojdo, J, additional, Vila Gonzalez, M, additional, Hu, Y, additional, Grieve, D, additional, Stitt, A W, additional, Zeng, L, additional, Xu, Q, additional, Margariti, A, additional, Reglin, B, additional, Xiang, W, additional, Nitzsche, B, additional, Maibier, M, additional, Pries, AR, additional, Vrijsen, KR, additional, Chamuleau, SAJ, additional, Verhage, V, additional, Metz, CHG, additional, Lodder, K, additional, Van Eeuwijk, ECM, additional, Van Dommelen, SM, additional, Doevendans, PA, additional, Smits, AM, additional, Goumans, MJ, additional, Sluijter, JPG, additional, Bova, M, additional, Loffredo, S, additional, Appleby, S, additional, Morrell, N, additional, Baranowska-Kuczko, M, additional, Kloza, M, additional, Ambrozewicz, E, additional, Kozlowski, M, additional, Malinowska, B, additional, Kozlowska, H, additional, Monti, M, additional, Terzuoli, E, additional, Ziche, M, additional, Mahmoud, AM, additional, Jones, AM, additional, Wilkinson, JA, additional, Romero, M, additional, Duarte, J, additional, Alexander, MY, additional, Faggian, G, additional, Kostareva, AA, additional, Malashicheva, AB, additional, Leurgans, TM, additional, Nguyen, TN, additional, Irmukhamedov, A, additional, Riber, LP, additional, Mcgeogh, R, additional, Comer, S, additional, Blanco Fernandez, A, additional, Ghigo, A, additional, Blaise, R, additional, Smirnova, NF, additional, Malet, N, additional, Vincent, P, additional, Limon, I, additional, Gayral, S, additional, Hirsch, E, additional, Laffargue, M, additional, Mehta, V, additional, Zachary, I, additional, Aidonidis, I, additional, Kramkowski, K, additional, Miltyk, W, additional, Kolodziejczyk, P, additional, Gradzka, A, additional, Szemraj, J, additional, Chabielska, E, additional, Dijkgraaf, I, additional, Bitsch, N, additional, Van Hoof, S, additional, Verhaegen, F, additional, Koenen, R, additional, Hackeng, TM, additional, Roshchupkin, D I, additional, Buravleva, K V, additional, Sergienko, VI, additional, Zhernossekov, DD, additional, Rybachuk, VM, additional, Grinenko, TV, additional, Furman, N, additional, Dolotovskaya, P, additional, Shamyunov, M, additional, Denisova, T, additional, Reiner, M, additional, Akhmedov, A, additional, Keller, S, additional, Miranda, M, additional, Briand, S, additional, Barile, L, additional, Kullak-Ublick, G, additional, Luscher, T, additional, Camici, G, additional, Guida, L, additional, Magnone, M, additional, Ameri, P, additional, Lazzarini, E, additional, Fresia, C, additional, Bruzzone, S, additional, Zocchi, E, additional, Di Paola, R, additional, Cordaro, M, additional, Crupi, R, additional, Siracusa, R, additional, Campolo, M, additional, Bruschetta, G, additional, Fusco, R, additional, Pugliatti, P, additional, Esposito, E, additional, Paloczi, J, additional, Ruivo, E, additional, Gaspar, R, additional, Dinnyes, A, additional, Kobolak, J, additional, Ferdinandy, P, additional, Gorbe, A, additional, Todorovic, Z, additional, Krstic, D, additional, Savic Vujovic, K, additional, Jovicic, D, additional, Basta Jovanovic, G, additional, Radojevic Skodric, S, additional, Prostran, M, additional, Dean, S, additional, Mee, CJ, additional, Harvey, KL, additional, Hussain, A, additional, Pena, C, additional, Paltineanu, B, additional, Voinea, S, additional, Revnic, F, additional, Ginghina, C, additional, Zaglia, T, additional, Ceriotti, P, additional, Campo, A, additional, Carullo, P, additional, Armani, A, additional, Coppini, R, additional, Vida, V, additional, Olivotto, I, additional, Stellin, G, additional, Rizzuto, R, additional, De Stefani, D, additional, Sandri, M, additional, Catalucci, D, additional, Mongillo, M, additional, Soumaka, E, additional, Kloukina, I, additional, Tsikitis, M, additional, Makridakis, M, additional, Varela, A, additional, Davos, C, additional, Vlachou, A, additional, Capetanaki, Y, additional, Iqbal, MM, additional, Bennett, H, additional, Davenport, B, additional, Pinali, C, additional, Cooper, G, additional, Cartwright, E, additional, Kitmitto, A, additional, Strutynska, NA, additional, Mys, LA, additional, Sagach, VF, additional, Franco, A, additional, Verzijl, A, additional, Stam, K, additional, Van Duin, R, additional, Reiss, IKM, additional, Duncker, DJ, additional, Merkus, D, additional, Shakeri, H, additional, Orije, M, additional, Leloup, AJ, additional, Van Hove, CE, additional, Van Craenenbroeck, EM, additional, De Meyer, GRY, additional, Vrints, CJ, additional, Lemmens, K, additional, Desjardins-Creapeau, L, additional, Wu, R, additional, Lamarre-Cliche, M, additional, Larochelle, P, additional, Bherer, L, additional, Girouard, H, additional, Melenovsky, M, additional, Kvasilova, A, additional, Benes, J, additional, Ruskova, K, additional, Sedmera, D, additional, Ana Barral, ABV, additional, Martin Fernandez, M, additional, Pablo Roman Garcia, PRG, additional, Juan Carlos Llosa, JCLL, additional, Manuel Naves Diaz, MND, additional, Cesar Moris, CM, additional, Jorge B Cannata-Andia, JBCA, additional, Isabel Rodriguez, IR, additional, Voevoda, M, additional, Gromova, E, additional, Maximov, V, additional, Panov, D, additional, Gagulin, I, additional, Gafarova, A, additional, Palahniuk, H, additional, Pashkova, IP, additional, Zhebel, NV, additional, Starzhynska, OL, additional, Naidoo, DP, additional, Rawojc, K, additional, Enguita, F J, additional, Grudzien, G, additional, Cordwell, SJ, additional, White, MY, additional, Massaro, M, additional, Martinelli, R, additional, Gatta, V, additional, Nasibullin, TR, additional, Erdman, VV, additional, Tuktarova, IA, additional, Mustafina, OE, additional, Hyttinen, J, additional, Severi, S, additional, Vorobyov, GG, additional, Batmyagmar, KH, additional, Lkhagvasuren, Z, additional, Gapon, LI, additional, Musikhina, NA, additional, Avdeeva, KS, additional, Dyachkov, SM, additional, Heinonen, I, additional, Van Kranenburg, M, additional, De Beer, VJ, additional, Octavia, Y, additional, Van Geuns, RJ, additional, Van Den Meiracker, AH, additional, Van Der Velden, J, additional, Everson, FP, additional, Ogundipe, T, additional, Grandjean, T, additional, De Boever, P, additional, Goswami, N, additional, Strijdom, H, additional, Suceveanu, A I, additional, Suceveanu, A P, additional, Mazilu, L, additional, Tofoleanu, D E, additional, Catrinoiu, D, additional, Rohla, M, additional, Hauser, C, additional, Huber, K, additional, Wojta, H, additional, Weiss, TW, additional, Melnikova, MA, additional, Olezov, NV, additional, Gimaev, RH, additional, Khalaf, H, additional, Ruzov, VI, additional, Adao, R, additional, Mendes-Ferreira, P, additional, Santos-Ribeiro, D, additional, Rademaker, M, additional, Leite-Moreira, AF, additional, Bras-Silva, C, additional, Alvarenga, LAA, additional, Falcao, RSP, additional, Dias, RR, additional, Lacchini, S, additional, Gutierrez, PS, additional, Michel, JB, additional, Gurfinkel, YU I, additional, Atkov, O YU, additional, Teichert, M, additional, Korn, C, additional, Mogler, C, additional, Hertel, S, additional, Arnold, C, additional, Korff, T, additional, Augustin, HG, additional, Van Duin, RWB, additional, De Wijs-Meijler, DPM, additional, D'alessandra, Y, additional, Farina, F M, additional, Casella, M, additional, Catto, V, additional, Carbucicchio, C, additional, Dello Russso, A, additional, Stadiotti, I, additional, Brambilla, S, additional, Chiesa, M, additional, Giacca, M, additional, Colombo, G I, additional, Tondo, C, additional, Ahlin, F, additional, Andric, T, additional, Tihanyi, D, additional, Wojta, J, additional, O'connell, E, additional, Butt, A, additional, Murphy, L, additional, Pennington, S, additional, Ledwidge, M, additional, Mcdonald, K, additional, Baugh, J, additional, Watson, C, additional, Suades, R, additional, Crespo, J, additional, Estruch, R, additional, Dyachenko, A, additional, Ryabukho, V, additional, Evtushenko, V, additional, Saushkina, YU, additional, Lishmanov, YU, additional, Smyshlyaev, K, additional, Bykov, A, additional, Popov, S, additional, Pavlyukova, E, additional, Anfinogenova, Y, additional, Szigetfu, E, additional, Kapornai, B, additional, Forizs, E, additional, Jenei, ZS, additional, Nagy, Z, additional, Merkely, B, additional, Zima, E, additional, Cai, A, additional, Dworakowski, R, additional, Gibbs, T, additional, Piper, S, additional, Jegard, N, additional, Mcdonagh, T, additional, Gegenava, M, additional, Dementieva, II, additional, Morozov, YUA, additional, Barsanti, C, additional, Stea, F, additional, Lenzarini, F, additional, Kusmic, C, additional, Faita, F, additional, Halonen, PJ, additional, Puhakka, PH, additional, Hytonen, JP, additional, Taavitsainen, JM, additional, Supit, E A, additional, Carr, C A, additional, Groenendijk, BCW, additional, Gorsse-Bakker, C, additional, Panasewicz, A, additional, Sneep, S, additional, Tempel, D, additional, Van Der Giessen, WJ, additional, Rys, J, additional, Daraio, C, additional, Dell'era, P, additional, Pigler, J, additional, Eder, A, additional, Eschenhagen, T, additional, Mazo, M M, additional, Amdursky, N, additional, Peters, N S, additional, Stevens, M M, additional, and Terracciano, C M, additional

Published
2016
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227. A novel route to synthesize Freidinger lactams by microwave irradiation

Author

LAMA, T, CAMPIGLIA, P, AURIEMMA, L, GOMEZ MONTERREY, CAROTENUTO, ALFONSO, NOVELLINO, ETTORE, GRIECO, PAOLO, Lama, T, Campiglia, P, Carotenuto, Alfonso, Auriemma, L, Gomez, Monterrey, Novellino, Ettore, and Grieco, Paolo

Subjects
chemistry.chemical_classification, Alkylation, Lactams, Molecular Structure, Stereochemistry, Chemistry, Molecular Conformation, Biochemistry, Amino acid, chemistry.chemical_compound, Endocrinology, Solid-phase synthesis, Electrophile, Peptide synthesis, Lactam, Side chain, Molecule, Amino Acids, Microwaves
Abstract

The incorporation of a Freidinger-like lactam structure into the backbone of peptides has been proven to be an useful strategy in the design of a variety of conformationally restricted targets. Several different strategies have been developed toward Freidinger lactams but no one resulted to be completely facile. Here, we report an efficient strategy that involves the iodo-derivatives in side chain of an appropriate amino acid used as electrophilic agent, and the standard solid phase peptide synthesis assisted by microwave irradiation. The methodology developed could be useful to perform Freidinger-like lactams with defined stereochemistry for routine use in solid phase peptide chemistry.

Published
2005

229. UT RECEPTOR LIGANDS. SWITCHING FROM AGONIST TO ANTAGONIST ACTIVITY

Author

CAROTENUTO, ALFONSO, GRIECO, PAOLO, MARINELLI, LUCIANA, NOVELLINO, ETTORE, Campiglia P, Rovero P., M. Flegel, M. Fridkin, C. Gilon, Carotenuto, Alfonso, Grieco, Paolo, Campiglia, P, Marinelli, Luciana, Novellino, Ettore, and Rovero, P.

Published
2004

230. UROTENSIN-II PEPTIDE AGONISTS AND ANTAGONISTS: A COMPREHENSIVE SAR STUDY

Author

GRIECO, PAOLO, NOVELLINO, ETTORE, MARINELLI, LUCIANA, CAROTENUTO, ALFONSO, Campiglia P., Rovero P., Patacchini R., Maggi C. A., Grieco, Paolo, Campiglia, P., Novellino, Ettore, Marinelli, Luciana, Rovero, P., Patacchini, R., Maggi, C. A., and Carotenuto, Alfonso

Published
2004

235. An antibody-free strategy for screening putative HDM2 inhibitors using crude bacterial lysates expressing GST-HDM2 recombinant protein

Author

Costa, Barbara, Grillone, Af, Salvetti, Alessandra, Rocchiccioli, S, Iacopetti, Paola, Daniele, Simona, DA POZZO, Eleonora, Campiglia, P, Novellino, E, Martini, Claudia, Rossi, Leonardo, B., Costa, A. F., Grillone, A., Salvetti, S., Rocchiccioli, P., Iacopetti, S., Daniele, E., Da Pozzo, P., Campiglia, Novellino, Ettore, C., Martini, and L., Rossi

Published
2013

237. Identification of a Potent Tryptophan-Based TRPM8 Antagonist With in Vivo Analgesic Activity.

Author

Bertamino, Alessia, Iraci, Nunzio, Ostacolo, Carmine, Ambrosino, Paolo, Musella, Simona, Di Sarno, Veronica, Ciaglia, Tania, Pepe, Giacomo, Sala, Marina, Soldovieri, Maria Virginia, Mosca, Ilaria, Gonzalez-Rodriguez, Sara, Fernandez-Carvajal, Asia, Ferrer-Montiel, Antonio, Novellino, Ettore, Taglialatela, Maurizio, Campiglia, Pietro, and Gomez-Monterrey, Isabel

Published
2018
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239. Solid State Multicolor Emission in Substitutional Solid Solutions of Metal–Organic Frameworks

Author

Newsome, Wesley J., Ayad, Suliman, Cordova, Jesus, Reinheimer, Eric W., Campiglia, Andres D., Harper, James K., Hanson, Kenneth, and Uribe-Romo, Fernando J.

Abstract

Preparing crystalline materials that produce tunable organic-based multicolor emission is a challenge due to the inherent inability to control the packing of organic molecules in the solid state. Utilizing multivariate, high-symmetry metal–organic frameworks, MOFs, as matrices for organic-based substitutional solid solutions allows for the incorporation of multiple fluorophores with different emission profiles into a single material. By combining nonfluorescent links with dilute mixtures of red, green, and blue fluorescent links, we prepared zirconia-type MOFs and found that the bulk materials exhibit features of solution-like fluorescence. Our study found that MOFs with a fluorophore link concentration of around 1 mol % exhibit fluorescence with decreased inner filtering, demonstrated by changes in spectral profiles, increased quantum yields, and lifetime dynamics expected for excited-state proton-transfer emitters. Our findings enabled us to prepare organic-based substitutional solid solutions with tunable chromaticity regulated only by the initial amounts of fluorophores. These materials emit multicolor and white light with high quantum yields (∼2–14%), high color-rendering indices (>93), long shelf life, and superb hydrolytic stability at ambient conditions.

Published
2019
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246. Peptides from Royal Jelly: studies on the antimicrobial activity of jelleins, jelleins analogs and synergy with temporins

Author

Romanelli A, Moggio L, Montella RC, Campiglia P, Iannaccone M, Capuano F, Pedone C, and Capparelli R.

Abstract

Peptides isolated from natural fonts are the object of several studies aimed at finding new molecules possessing antibacterial activity. We focused our studies on peptides originally isolated from the Royal Jelly, the jelleins and on some analogs having a UV reporter at the N- or C-terminus. We found that jelleins are mainly active against gram-positive bacteria; interestingly, they act in synergy with peptides belonging to the family of temporins such as temporin A and temporin B against Staphylococcus aureus A170 and Listeria monocytogenes.

Published
2011
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