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1,300 results on '"Cai, Kaiyong"'

206. Co‐Assembly Induced Solid‐State Stacking Transformation in Amino Acid‐Based Crystals with Enhanced Physical Properties

Author

Ji, Wei, primary, Yuan, Hui, additional, Xue, Bin, additional, Guerin, Sarah, additional, Li, Hui, additional, Zhang, Lei, additional, Liu, Yanqing, additional, Shimon, Linda J. W., additional, Si, Mingsu, additional, Cao, Yi, additional, Wang, Wei, additional, Thompson, Damien, additional, Cai, Kaiyong, additional, Yang, Rusen, additional, and Gazit, Ehud, additional

Published
2022
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207. Enhanced Immunogenic Cell Death and Antigen Presentation viaEngineered Bifidobacterium bifidumto Boost Chemo-immunotherapy

Author

He, Tingting, Wang, Lu, Gou, Shuangquan, Lu, Lu, Liu, Genhua, Wang, Kui, Yang, Yulu, Duan, Qiaojian, Geng, Wenbo, Zhao, Peng, Luo, Zhong, and Cai, Kaiyong

Abstract

The immunogenic cell death (ICD) of tumor cells has aroused great interest in the field of immunotherapy, mainly due to the production of plentiful tumor-associated antigens (TAAs) and damage-associated molecule patterns. However, doxorubicin (DOX)-induced tumor-specific T-cell-mediated immune response is usually very weak because of antigen presentation deficiency and the immunosuppressive tumor microenvironment (ITME). Herein, the probiotic Bifidobacterium bifidum(Bi) was covalently modified with DOX-loaded CaP/SiO2nanoparticles (DNPs@Bi) for tumor therapy. On one hand, the pH-responsive release of DOX could induce chemotherapy and ICD in the ITME. On the other hand, tumor-targeting Bi is able to significantly enhance the presentation of TAAs from B16F10 cells to DCs viaCx43-dependent gap junctions. Due to the combination of enhanced ICD and TAAs presentation, the maturation of DCs and the infiltration of cytotoxic T lymphocytes in the ITME were stimulated. As a result, in vivoantitumor experiments demonstrated that DNPs@Bi prolonged the survival rate and significantly inhibited the tumor progression and metastasis. This strategy of bacterial-driven hypoxia-targeting delivery systems offers a promising approach to tumor chemo-immunotherapy.

Published
2023
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211. Multienzyme-like Reactivity Cooperatively Impairs Glutathione Peroxidase 4 and Ferroptosis Suppressor Protein 1 Pathways in Triple-Negative Breast Cancer for Sensitized Ferroptosis Therapy

Author

Li, Ke, primary, Lin, Chuanchuan, additional, Li, Menghuan, additional, Xu, Kun, additional, He, Ye, additional, Mao, Yulan, additional, Lu, Lu, additional, Geng, Wenbo, additional, Li, Xuemin, additional, Luo, Zhong, additional, and Cai, Kaiyong, additional

Published
2022
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222. A Transferrin-Conjugated Hollow Nanoplatform for Redox-Controlled and Targeted Chemotherapy of Tumor with Reduced Inflammatory Reactions: Erratum

Author

Zhou, Jun, primary, Li, Menghuan, additional, Lim, Wei Qi, additional, Luo, Zhong, additional, Phua, Soo Zeng Fiona, additional, Huo, Runlan, additional, Li, Liqi, additional, Li, Ke, additional, Dai, Liangliang, additional, Liu, Junjie, additional, Cai, Kaiyong, additional, and Zhao, Yanli, additional

Published
2022
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235. Calcium Peroxide Nanoparticles‐Embedded Coatings on Anti‐Inflammatory TiO 2 Nanotubes for Bacteria Elimination and Inflammatory Environment Amelioration

Author

He, Ye, primary, Li, Ke, additional, Yang, Xin, additional, Leng, Jin, additional, Xu, Kun, additional, Yuan, Zhang, additional, Lin, Chuanchuan, additional, Tao, Bailong, additional, Li, Xuan, additional, Hu, Jingwei, additional, Dai, Liangliang, additional, Becker, Ryan, additional, Huang, Tony Jun, additional, and Cai, Kaiyong, additional

Published
2021
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237. Polydopamine Nanosheets Doped Injectable Hydrogel with Nitric Oxide Release and Photothermal Effects for Bacterial Ablation and Wound Healing

Author

Liu, Genhua, primary, Wang, Lu, additional, He, Ye, additional, Wang, Liucan, additional, Deng, Zhiwen, additional, Liu, Junjie, additional, Peng, Dan, additional, Ding, Tao, additional, Lu, Lu, additional, Ding, Yao, additional, Zhang, Jixi, additional, Liu, Peng, additional, and Cai, Kaiyong, additional

Published
2021
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243. Surface modification of titanium implant for repairing/improving microenvironment of bone injury and promoting osseointegration.

Author

Ding, Yao, Tao, Bailong, Ma, Ruichen, Zhao, Xin, Liu, Peng, and Cai, Kaiyong

Subjects
OSSEOINTEGRATION, TITANIUM, BONE injuries, MESENCHYMAL stem cell differentiation, ORTHOPEDIC implants, SPRAGUE Dawley rats, BONE regeneration
Abstract

• A coating consist of MnO 2 nanoenzyme and Sr ions was fabricated on Ti implant. • MnO 2 nanoenzyme alleviated OA and O 2 deficiency at the injury site. • Sr ions released from the surface of implant promoted the growth of MSCs. • The modified Ti implant significantly accelerate bone regeneration in vivo. Bone injury and implantation operation are often accompanied by microenvironment damage of bone tissue, which seriously affects the process of osseointegration of implants, especially for titanium (Ti)-based bioinert materials. Thus, repairing or improving the microenvironment of damaged bone tissue is of great significance for bone rescue, reconstruction, and regeneration, which is still a major medical challenge. Oxidative stress (OS) and oxygen (O 2) deficiency are considered to be specific physiological signals of the bone-injury microenvironment. From the above background, a coating consisting of manganese dioxide (MnO 2) nanoenzyme and strontium (Sr) ions was fabricated on the surface of the Ti implant via a one-step hydrothermal treatment. MnO 2 nanoenzyme presented in the coating alleviated OS and O 2 deficiency at the injury site by catalyzing the decomposition of abundant endogenous H 2 O 2 around the modified Ti implants into O 2. In addition, Sr ions were released from the surface of the implant at a certain rate in a body-fluid environment, further promoting the adhesion, growth, and osteogenic differentiation of mesenchymal stem cells. More importantly, a Sprague Dawley rat femur model demonstrated that the modified Ti implant showed significant potential to accelerate bone tissue reconstruction in vivo. In summary, the present system provides a new idea for the treatment of bone injury and the development of new orthopedic implants. [ABSTRACT FROM AUTHOR]

Published
2023
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244. A HAase/NIR responsive surface on titanium implants for treating bacterial infection and improving osseointegration.

Author

Li, Dan, Wang, Danyang, He, Ye, Tao, Bailong, Liu, Xiaoxia, Yang, Yulu, Tan, Lu, Zhang, Yuchen, Hu, Jingwei, Yang, Weihu, Tang, Yu, and Cai, Kaiyong

Subjects
BACTERIAL diseases, PHOTOTHERMAL effect, OSSEOINTEGRATION, BACTERIAL adhesion, TITANIUM
Abstract

• A mild antibacterial system for S. aureus and MRSA was constructed based on the synergistic effect of photothermal and antibiotic. • Antibiotic in MPDA can be sealed with HAc, which can avoid the damage to normal tissue caused by the burst release CIP and inhibit the early adhesion of bacteria. • Bacteria can secrete bacterial hyaluronidase to accelerate the degradation of HAc, realizing the smart enzyme-triggered release of antimicrobials at the site of infection on demand. • NIR light irradiation can not only accelerate the CIP release but also activate the photothermotherapy of MPDA nanoparticles. Bacterial infection and insufficient osseointegration are critical factors affecting the long-term success of titanium-based implants. Unfortunately, the direct application of antibiotic on Ti implants easily leads to poor cytocompatibility, as well as the production of drug-resistant bacteria. So, in this work, we designed a prospective antibacterial strategy by combining photothermal and ciprofloxacin (CIP). The synergistic effect of photothermal and antibiotic may provide an effective bacteriostatic efficacy without sacrificing osteogenesis at a mild condition of moderate temperature and less antibiotic. Herein, CIP was loaded into mesoporous polydopamine (MPDA) nanoparticles (MPDA@CIP), which were anchored on the surface of titanium and finally covered with sodium hyaluronate-catechol (HAc) coating. The hydrophilic HAc layer could inhibit the early adhesion of bacteria, and some bacteria could secrete bacterial hyaluronidase to accelerate the degradation of HAc. This enabled smart enzyme-triggered release of antimicrobials at the site of infection on-demand and avoided unwanted side effects on normal tissues. In addition, NIR light irradiation had a positive influence on both CIP release and MPDA nanoparticle's photothermal effect. Moreover, before anchoring MPDA@CIP, by the construction of hydroxyapatite microstructure on Ti surface with micro-arc oxidation and alkali heat treatment, the ability of bone formation of Ti could be promoted also. Both in vitro as well as in vivo assays demonstrated that functional Ti has an excellent antibacterial effect and osteogenic ability. [ABSTRACT FROM AUTHOR]

Published
2023
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246. Combination wound healing using polymer entangled porous nanoadhesive hybrids with robust ROS scavenging and angiogenesis properties.

Author

Huang, Jixi, Wang, Shuai, Wang, Xiaoping, Zhu, Jing, Wang, Zhenqiang, Zhang, Ximu, Cai, Kaiyong, and Zhang, Jixi

Subjects
POROUS polymers, WOUND healing, HEALING, NEOVASCULARIZATION, SILICA nanoparticles, MESOPOROUS silica, POLYMERS, POLYVINYL alcohol
Abstract

Nanoadhesives can achieve tight wound closure by connecting biomacromolecules from both sides. However, previously developed adhesive systems suffered from suboptimal wound healing efficiency due to the lack of interparticle cohesion, sufficient reactive oxygen species (ROS)-scavenging sites, and angiogenesis consideration. Herein, we developed a polymer entangled porous nanoadhesive system to address the above challenge by synergy of three functional components. Firstly, hybrid mesoporous silica nanoparticles with highly integrated polydopamine (MS-PDA) were prepared by templated synthesis. The entangling between PVA polymer and MS-PDA contributed to much stronger cohesion between nanoparticles, which led to 75% larger adhesion strength. As confirmed by in vitro and in vivo evaluations, the highly exposed catechol groups boosted the scavenging activity of ROS (1.8–4.1 fold enhancement as compared with nonporous counterpart). Consequently, more macrophages exhibited anti-inflammatory phenotype, leading to 2–2.6 fold lower pro-inflammatory cytokine levels. Moreover, the sustained release of bioactive SiO 4 4− by the disintegration of nanoparticles contributed to ∼3-fold higher expression of VEGF and enhanced new blood vessel formation, as well as better wound repair. This platform can provide a new paradigm for developing multifunctional nanoadhesive systems in treating skin wounds. PVA polymer entangled mesoporous nanoadhesives of polydopamine (PDA)/silica hybrids with the combination of excellent wound closure effect, boosted ROS-scavenging activity, and significant angiogenesis ability were developed for improving the suboptimal skin wound healing efficiency. This strategy not only greatly advances our ability to rationally integrate repairing elements in nanoadhesives for manipulating combined processes of interfacial events during wound healing, but also offers general implications toward application of polymers to reinforce the adhesion strength in nanoadhesive systems. In addition, our findings on the impacts of pore effects mediated ROS species conversion and polymer entanglement may also trigger great interests and facilitate the development/broad application of therapeutic adhesives. [Display omitted] [ABSTRACT FROM AUTHOR]

Published
2022
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247. A protein-based cGAS-STING nanoagonist enhances T cell-mediated anti-tumor immune responses.

Author

Wang, Xuan, Liu, Yingqi, Xue, Chencheng, Hu, Yan, Zhao, Yuanyuan, Cai, Kaiyong, Li, Menghuan, and Luo, Zhong

Subjects
IMMUNE response, FERRITIN, DENDRITIC cells, SERUM albumin, TUMOR microenvironment, MANGANESE, ANIMAL models in research
Abstract

cGAS-STING pathway is a key DNA-sensing machinery and emerges as a promising target to overcome the immunoresistance of solid tumors. Here we describe a bovine serum albumin (BSA)/ferritin-based nanoagonist incorporating manganese (II) ions and β-lapachone, which cooperatively activates cGAS-STING signaling in dendritic cells (DCs) to elicit robust adaptive antitumor immunity. Mn2+-anchored mannose-modified BSAs and β-lapachone-loaded ferritins are crosslinked to afford bioresponsive protein nanoassemblies, which dissociate into monodispersive protein units in acidic perivascular tumor microenvironment (TME), thus enabling enhanced tumor penetration and spatiotemporally controlled Mn2+ and β-lapachone delivery to DCs and tumor cells, respectively. β-lapachone causes immunogenic tumor cell apoptosis and releases abundant dsDNA into TME, while Mn2+ enhances the sensitivity of cGAS to dsDNA and augments STING signaling to trigger downstream immunostimulatory signals. The cGAS-STING nanoagonist enhances the tumor-specific T cell-mediated immune response against poorly immunogenic solid tumors in vivo, offering a robust approach for immunotherapy in the clinics. Manganese has a crucial role in cGAS-STING-mediated DNA sensing and has emerged as a STING agonist. Here the authors report the design and characterization of a nanosystem incorporating manganese ions and the chemotherapeutic drug β-lapachone, inducing T-cell mediated anti-tumor immune responses in preclinical cancer models. [ABSTRACT FROM AUTHOR]

Published
2022
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