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Das Standardwerk für alle in der Geburtshilfe und Perinatalmedizin tätigen Ärztinnen und Ärzte und Interessierte liegt nun unter neuer Herausgeberschaft vor. In der 6. Auflage komplett aktualisiert und dem aktuellen evidenzbasierten Wissen und Methoden angepasst. Mehr als die Hälfte der Kapitel mit neuer Autorenschaft und erweitert um neue Themen, u.a. Adipositas und Schwangerschaft, Geburtsmodus bei fetalen Fehlbildungen, Management von Placenta increta, Patient Blood Management. Plus: Von der Evidenz zur Handlungsempfehlung, praktisches geburtshilfliches multiprofessionelles Traning. „Die Geburtshilfe“ beantwortet die zahlreichen Fragen, die sich Ärztinnen und Ärzte und Hebammen rund um die Themen Schwangerschaft, Geburt und Perinatalmedizin stellen. Verständlich, klar strukturiert und an der Praxis orientiert mit eindeutigen Angaben zur Dosierung von Medikamenten, Algorithmen und Hinweisen auf Komplikationen. Als ebook und Live-Reference ermöglicht es den direkten Zugriff zu jeder Zeit sowie auf Links zu wichtigen Websites. Für eine kompetente und einfühlsame Betreuung und Begleitung der werdenden Mutter von der Schwangerschaft bis nach der Entbindung.

Methotrexat ist bereits Mitte der 1980er Jahre als neues Basistherapeutikum der rheumatoiden Arthritis verbreitet eingeführt worden, in der Entzündungsmedizin aber trotz oder gerade wegen der zahlreichen inzwischen zugelassenen Medikamente nach wie vor hochaktuell. Neben der Behandlung rheumatologischer Krankheitsbilder kann es auch in der Dermatologie und in der Therapie chronisch entzündlicher Darmerkrankungen eingesetzt werden. Die mittlerweile 3. Auflage dieses Buches ist ein umfassendes Werk rings um Methotrexat als Monotherapie und als Kombinationspartner, welches alle Fragen für die klinische Praxis nach aktuellem Stand des Wissens beantwortet und dem Leser als täglicher Begleiter dienen soll.

Eine umfassende und fundierte Hebammenbetreuung wirkt sich protektiv auf die Schwangerschaft und auf eine physiologische Geburt aus. Das Praxisbuch zeigt den evidenten Rahmen und die Grenzen von Hebammenarbeit im Kontext der Schwangerenvorsorge und -beratung auf. Konkrete Arbeitsweisen einer Hebamme, z. B. zur Sicherstellung eines zeitgerechten fetalen Wachstums, werden ebenso behandelt wie frühe Hinweise auf Frühgeburtsbestrebungen oder hypertensive Komplikationen. Besondere Erfordernisse von Frauen mit ausgewählten chronischen Erkrankungen werden ebenfalls vorgestellt. Beratungsinhalte zu einem gesundheitsförderlichen Lebensstil werden u. a. am Beispiel der schwangeren Gewichtsentwicklung, Ernährung und Bewegungsförderung, der Rauchentwöhnung, der Anleitung zu geburtsvorbereitenden Maßnahmen sowie bei Leistungsabfall und Schlafstörungen erläutert, wobei klare Empfehlungen ausgesprochen werden. Die 2. Auflage berücksichtigt die aktualisierten Aussagen und Evidenzen zu den genannten Inhalten, wodurch ein sicherer Rahmen für die Betreuung, Beratung und Vorsorge von Schwangeren geschaffen wird.

Essential for ob/gyn physicians, primary care physicians, and any health care provider working with pregnant or postpartum women, Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk, 12th Edition, puts must-know information at your fingertips in seconds. An easy A-to-Z format lists more than 1,400 of the most commonly prescribed drugs taken during pregnancy and lactation, with detailed monographs designed to provide the most essential information on possible effects on the mother, embryo, fetus, and nursing infant.

Comprehensive Pharmacology, Seven Volume Set is organized into twelve sections that explore therapeutic areas, with a total of 320 comprehensive articles and 6,800 pages of important findings. Sections contain highly detailed coverage of information that has been overseen by an editorial board made up of well-respected, field leading experts. The content in this book offers readers an in-depth and easily accessible reference work on every aspect of pharmacological research surrounding the pharmacology of all therapeutic applications of drugs, their mechanism of action and their therapeutic values. These elements are essential as drugs are almost never tested and developed in the actual therapeutic system, but rather in test systems from which parameters must be determined to predict activity in systems of varying ambient physiology. As different technologies rapidly evolve, there is an ever-increasing level of knowledge about the pharmacology of known drugs, along with increasing capability to utilize pharmacological systems to predict new drug activity, all of which must be communicated to professionals in varying fields. - Contains chapters that follow a consistent and templated approach, resulting in well-structured content that enhances user experience and appeal - Offers a comprehensive review on a wealth of information on pharmacology and how it utilizes concepts and techniques from a broad array of sciences, ranging from chemistry to physiology to medicine - Includes a wider use of color and multimedia content, with interactive features, links, computational modeling and animations to illustrate the effects of toxic substances in various contexts

Reproductive Immunology: Basic Concepts gives a holistic insight into the understanding of the complex interactions between the maternal immune system and the fetal/placental unit necessary for the success of pregnancy. This interaction is critical for the support of the human fetal semiallograft and the protection against infections. The book covers various topics such as B cells, macrophages, T cells, discussion on fetal signals and their impact on maternal reproductive cells such as endometrial cells, mast cells, and the role of fetal Hofbauer cells, the immune regulatory role of glucorticoids, and many other novel topics within the field of reproductive immunology. Edited and written by experts in the field, this book introduces the up-to-date knowledge of the role of the immune system during pregnancy and provides the necessary background to understand pregnancy complications associated with alterations in the functioning of the immune system. The book provides a complete discussion on the immunological aspects of pregnancy and serves as a great tool for research scientists, students, reproductive immunologists and OBGYNs. - Shows the detailed evaluation of the knowledge related to each immune cell type in the pregnant and not pregnant uterus - Evaluates each immune cell type and its function during specific reproductive events - Provides the biological background for understanding the clinical aspects that will be discussed in subsequent volumes in the series

Infections in Systemic Autoimmune Diseases: Risk Factors and Management, Volume Sixteen describes the state-of-the-art of the risk factors and management treating the most common systemic autoimmune diseases (SADS). This updated volume consists of an introductory chapter that provides a brief overview of what different types of infectious diseases exist, followed by eight chapters detailing risk factors, guidelines and recommendations per different disease and bacterial infections. International in scope, the list of more than 20 contributors from Europa and America reads like a who's who of clinical researchers in the field. - Written by leading international clinical/surgical and scientific experts on Infection problems in systemic autoimmune diseases - Provides a practical guide to the safer treatment of infections in patients with autoimmune diseases - Includes a number of problems and recommendation that cannot be found in other books - Designed as a'guide to clinical practice'for management and risk interventions required by patients with SAD's

Surgery in Systemic Autoimmune Disease, Volume 15, describes the state-of-the-art of the use of surgery in treating the most common systemic autoimmune diseases (SADS). The volume consists of an introductory chapter concerning the impact of surgery on SADs, follow by eight chapters describing the use of surgery in the treatment of specific diseases in various areas (cardiology, gastroenterology, orthopedics, neurology. etc.) and the possible difficulties and complications. The final five chapters deal with the possible complications arising during the course of biological and non-biological treatment, also providing recommendation concerning their management. International in scope, the list of more than 20 contributors from Europa and America reads like a who's who of clinical researchers in the field. - Written by leading international clinical/surgical and scientific experts on surgical problems in SADs - Provides a practical guide to the safer use of surgery in patients with autoimmune diseases - Includes a number of problems and recommendations that cannot be found in other books - Designed as a'guide to clinical practice'for surgical interventions required by patients with SADs - Gives a comprehensive review of the available surgical options

​Dieses Buch erleichtert dem Leser den Weg vom Symptom zur Diagnose bei rheumatischen Krankheitsbildern: Abgebildet ist das gesamte Spektrum der international den rheumatischen Erkrankungen zugeordneten muskuloskelettalen Schmerzen und Krankheiten in ihren differenzialdiagnostischen Aspekten. Einer ausführlichen Darstellung der Grundlagen folgt eine detaillierte Beschreibung aller wichtigen Differenzialdiagnosen mit über 200 Tabellen und Übersichten. Die fünfte Auflage dieses Standardwerks wurde von neuen Autoren komplett überarbeitet und aktualisiert.

This special supplement to the Key Indicators for Asia and the Pacific 2018 showcases the role that technology can play in improving the quality, timeliness, and frequency of agricultural statistics. The first part presents a summary of existing methods for collecting land area, production, and yield data in the region. The second part discusses measurement errors associated with the existing data collection methods. The third part presents ways to address these measurement errors using remote sensing technology by showcasing results from three methodological research activities undertaken by the Asian Development Bank in three countries: the Lao People's Democratic Republic, Thailand, and Viet Nam. This report concludes with a summary of how other innovations, such as drones, computer-assisted personal interviewing, and artificial intelligence hold promise in transforming the field of agricultural statistics.

Put essential information at your fingertips – before you prescribe. The updated 11th edition of Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk lists more than 1,200 commonly prescribed drugs taken during pregnancy and lactation, with detailed monographs that provide the information you need on known or possible effects on the mother, embryo, fetus, and nursing infant. For the 11th edition, this bestselling reference has two new authors, both highly knowledgeable on the effects of drugs on the embryo-fetus and nursing infant: Craig V. Towers, a maternal-fetal medicine specialist, and Alicia B. Forinash, a clinical pharmacologist specialist in obstetrics.

The Heart in Systemic Autoimmune Diseases, Second Edition, provides an overview on our current understanding of major complications relating to the heart and autoimmune diseases. It includes the latest information on the new pathogenetic mechanisms involved, along with clinical manifestations of these important comortbidities. Mortality in autoimmune diseases, in particular, rheumatoid arthritis and SLE, has increased when compared with the general population. This excess mortality is largely due to cardiovascular diseases (CVDs)-particularly those of atherosclerotic origin, such as ischemic heart disease-and is gaining recognition in all branches of medicine, from cardiology, to internal medicine, and from rheumatologists to orthopedics. - Presents an impressive body of well ordered information on the topic of cardiovascular diseases and their relationship to autoimmune illness - Highlights key references - Summarizes the experience of a selected panel of distinguished physician-scientists who are actively involved in the field of cardiovascular disease and systemic autoimmunity

Ten years ago, the first edition of Graves'Orbitopathy: A Multidisciplinary Approach was published. Since then, the book has become very popular and much has happened in the field to warrant a third edition. What has not changed is the successful and attractive question-and-answer format of the book. In the 3rd, revised and expanded edition, new chapters have been added on co-morbidity, local treatment modalities, novel immunosuppressive therapy, detailed protocols, and questions frequently asked by patients. All chapters of the previous edition have been thoroughly updated. Subjects covered then include the pathology of Graves'Orbitopathy (GO) and the controversial views on its pathogenesis; assessment of changes using reliable measuring techniques; medical management of GO including established and alternative treatment options; technical explanations and illustrations of various surgical procedures; and finally, the molecular, immunologic, and clinical aspects of this complex disorder. Additionally, ample consideration is given to the new 2016 ETA/EUGOGO guidelines on the management of GO.

This book explores comorbidity in patients with rheumatic diseases and details both care and treatment options in standard clinical practice. Patients with rheumatic diseases are clinically complex, and the interplay of their disease activity with associated conditions may lead to increased morbidity and mortality. Recently there have been major advances in the management of rheumatic diseases, however, without addressing the potential comorbid conditions, including cardiovascular disease; pulmonary disease; and depression; outcomes remain poor. ​​​ With its 19 chapters, covering the management of major rheumatic diseases (e.g. rheumatoid arthritis, systemic lupus erythematosus, and osteoarthritis), potential comorbidities and treatment recommendations, as well as possible interactions between conditions; this book addresses the gap between textbook medicine and day to day patients'care. Authors also discuss the new hot issue of the comorbidity index, comparing the standard tools to the recently developed indices and how they can assist the rheumatologists in determining disease burden, prognosis, and comorbidity probability. This book is an ideal clinical guide and reference that enables rheumatologists, internal medicine physicians, and residents to address the full clinical expression of these rheumatic diseases with views towards prevention or early management of comorbid conditions.

Este manual, que surgen de la mano de la Sociedad Española de Reumatología (SER), ha sido elaborado por profesionales de reconocido prestigio dentro del ámbito de la reumatología. Todos ellos son miembros de la SER y cuentan con una amplia trayectoria clínica. La sexta edición del Manual SER de Enfermedades Reumáticas tiene como principal objetivo propiciar una consulta ágil y fiable, por lo que es una obra de gran utilidad, tanto en la práctica clínica como en la docencia de las enfermedades reumáticas. La obra recoge las últimas novedades del campo de la Reumatología. Por ello, se ha llevado a cabo la necesaria actualización del contenido científico, surgido a consecuencia del rápido aumento del conocimiento que se ha dado en los últimos tiempos sobre todos los aspectos relacionados con el cuidado, en el más amplio sentido de la palabra, de los pacientes reumáticos.La obra no sólo está dirigida a reumatólogos sino también a especialistas afines y a cualquier profesional sanitario interesado en el conocimiento de las enfermedades reumáticas.

This comprehensive volume provides current state of the art of the use of corticosteroids in the pediatric patient. It consists of 14 chapters written by leading authors from different countries. The first chapters cover historical notes, general concepts on treatment with corticosteroids with regard to indications and side effects, and basic pharmacologic properties of these compounds. The rest of the book is devoted to the specific use of steroids in the different pediatric subspecialties. Despite advances with newer effective immunosuppressive and anti-inflammatory drugs, corticosteroids still remain the mainstay of therapy for many disorders. Leading authors in their field have summarized these concepts to provide an authoritative, comprehensive guide to help clinicians safely and effectively use corticosteroids in their pediatric patients.

This book offers a comprehensive guide to total knee arthroplasty (TKA) that will assist in achieving excellent outcomes based on a sound understanding and technique. After an introductory section on the native knee that covers the anatomy, physiology, biomechanics, and patterns of disease, all aspects of primary knee arthroplasty are discussed in detail. Individual chapters are devoted to topics such as acute pain management, the role of technological aids, prosthetic kinematics, alignment targets, unicompartmental arthroplasty, patellar resurfacing, outcome measures, and cost-effectiveness. An extensive section explains the causes and management of potential complications, including aseptic failure, infections, and periprosthetic fracture. The surgical techniques appropriate for revision knee arthroplasty are described separately, and guidelines on how to deal with bone loss, instability, and extensor mechanism failure are provided. The authors are all respected experts from the United Kingdom, United States, Australia and Europe.

The Side Effects of Drugs Annual was first published in 1977. It has been continually published since then as a yearly update to the voluminous encyclopedia, Meyler's Side Effects of Drugs. Each new Annual continues to provide clinicians and medical investigators with a reliable and critical yearly survey of new data and trends in the area of adverse drug reactions and interactions. An international team of specialists has contributed to the informative Annual by critically interpreting it and by pointing to whatever is misleading. - Provides a critical yearly survey of new data and trends - Special reviews in this Annual include, among other topics, epidemiology of the use of ecstasy, paracetamol and the risk of asthma, combination vaccines/multiple immunizations, interactions of herbal medicines with warfarin, and tyrosine kinase inhibitors

This continuing series gathers and presents original research results on the leading edge of medicine and biology. Each article has been carefully selected in an attempt to present substantial topical data across a broad spectrum. Topics discussed in this compilation include a review on the optimization of the formulations of metronidazole through a different administration route; the use of metronidazole in cancer gene therapy and targeted cell ablation; protective roles of glutathione peroxidases in diabetes; stem cell disorders and bone marrow transplantation; catalase gene mutant mice; what animal models of inflammatory arthritis teach us about bone damage; methylprednisolone use in autoimmune diseases; the clinical use of methylprednisolone in oncology; how pretreatment with methylprednisolone reduces adverse clinical effects of inflammatory response induced by heart surgery and cardiopulmonary bypass; and the potential side effects of methylprednisolone.

Die Krankheiten des rheumatischen Formenkreises werden immer bedeutsamer. Die Kenntnisse über Molekularbiologie, Immunologie, medikamentöse und chirurgische Therapie haben rasant zugenommen. Umfassend und praxisnah präsentiert dieses Buch die Rheumatologie mit all ihren Randgebieten. Im allgemeinen Teil wird u.a. auf die Bausteine des Bindegewebes, Immunologie, Genetik und Epidemiologie eingegangen, gefolgt von einem Teil über Diagnostik und Krankheitsbilder und einem therapeutischen Teil, der alle medikamentösen, nicht-medikamentösen und chirurgisch-orthopädischen Aspekte beinhaltet. In den klinischen Kapiteln wird durchgehend eine übersichtliche Gliederung eingehalten. Die fünfte Auflage wurde um aktuelle Themen, wie Biologika in die Therapie der entzündlichen rheumatischen Erkrankungen, die intensive Behandlung der Früharthritis und besserer Therapieerfolg durch Einführung einheitlicher klinischer Messkriterien erweitert. Eine geglückte Synthese von fundiertem Handbuch und praktischer Checkliste.

This book is one of the first to evaluate the role of Steroids in autoimmune rheumatic diseases from the basic mechanisms to the clinical involvements and focuses on the importance of steroidal hormones in the pathogenesis and therapeutic management of the autoimmune rheumatic diseases. In particular, the chapters analyze the mechanisms of action and the involvement of adrenal steroids (glucocorticoids) in the neuroendocrine immune system, including effects on the elderly. The perturbations of the HPA axis as a source of altered steroidal synthesis will be discussed and related to some interesting pathological conditions that commonly complicate the autoimmune rheumatic diseases such as psychosis or fibromyalgia. Concerning the role of gonadal steroids (sex hormones), several chapters will discuss clinical and epidemiological evidences of their role, as well as their effects as risk factors in autoimmune rheumatic diseases, including a section on pediatrics. - The premier issue evaluating the role of steroids in autoimmune rheumatic diseases from the basic mechanisms to the clinical involvements - Documents the latest research and indicate recent and coming new therapeutic-biological approaches to the therapy - The book will present therapeutic perspectives concerning the new glucocorticoids, and the effects of biological drugs on their synthesis