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816 results on '"Buatti, John M"'

206. Paddle-based rotating-shield brachytherapy.

Author

Yunlong Liu, Flynn, Ryan T., Dadkhah, Hossein, Bhatia, Sudershan K., Buatti, John M., Weiyu Xu, and Xiaodong Wu

Subjects
RADIOISOTOPE brachytherapy, COLLIMATORS, CERVICAL cancer patients, INTENSITY modulated radiotherapy, CANCER radiotherapy, RADIATION doses
Abstract

Purpose: The authors present a novel paddle-based rotating-shield brachytherapy (P-RSBT) method, whose radiation-attenuating shields are formed with a multileaf collimator (MLC), consisting of retractable paddles, to achieve intensity modulation in high-dose-rate brachytherapy. Methods: Five cervical cancer patients using an intrauterine tandem applicator were considered to assess the potential benefit of the P-RSBT method. The P-RSBT source used was a 50 kV electronic brachytherapy source (Xoft Axxent™). The paddles can be retracted independently to form multiple emission windows around the source for radiation delivery. The MLC was assumed to be rotatable. P-RSBT treatment plans were generated using the asymmetric dose–volume optimization with smoothness control method [Liu et al., Med. Phys. 41(11), 111709 (11pp.) (2014)] with a delivery time constraint, different paddle sizes, and different rotation strides. The number of treatment fractions (fx) was assumed to be five. As brachytherapy is delivered as a boost for cervical cancer, the dose distribution for each case includes the dose from external beam radiotherapy as well, which is 45 Gy in 25 fx. The high-risk clinical target volume (HR-CTV) doses were escalated until the minimum dose to the hottest 2 cm³ (D2cm³) of either the rectum, sigmoid colon, or bladder reached their tolerance doses of 75, 75, and 90 Gy3, respectively, expressed as equivalent doses in 2 Gy fractions (EQD2 with α/β = 3 Gy). Results: P-RSBT outperformed the two other RSBT delivery techniques, single-shield RSBT (S-RSBT) and dynamic-shield RSBT (D-RSBT), with a properly selected paddle size. If the paddle size was angled at 60°, the average D 90 increases for the delivery plans by P-RSBT on the five cases, compared to S-RSBT, were 2.2, 8.3, 12.6, 11.9, and 9.1 Gy10, respectively, with delivery times of 10, 15, 20, 25, and 30 min/fx. The increases in HR-CTV D 90, compared to D-RSBT, were 16.6, 12.9, 7.2, 3.7, and 1.7 Gy10, respectively. P-RSBT HR-CTV D 90-values were insensitive to the paddle size for paddles angled at less than 60°. Increasing the paddle angle from 5° to 60° resulted in only a 0.6 Gy10 decrease in HR-CTV D 90 on average for five cases when the delivery times were set to 15 min/fx. The HR-CTV D 90 decreased to 2.5 and 11.9 Gy10 with paddle angles of 90° and 120°, respectively. Conclusions: P-RSBT produces treatment plans that are dosimetrically and temporally superior to those of S-RSBT and D-RSBT, although P-RSBT systems may be more mechanically challenging to develop than S-RSBT or D-RSBT. A P-RSBT implementation with 4–6 shield paddles would be sufficient to outperform S-RSBT and D-RSBT if delivery times are constrained to less than 15 min/fx. [ABSTRACT FROM AUTHOR]

Published
2015
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208. Promise and pitfalls of quantitative imaging in oncology clinical trials

Author

Kurland, Brenda F., primary, Gerstner, Elizabeth R., additional, Mountz, James M., additional, Schwartz, Lawrence H., additional, Ryan, Christopher W., additional, Graham, Michael M., additional, Buatti, John M., additional, Fennessy, Fiona M., additional, Eikman, Edward A., additional, Kumar, Virendra, additional, Forster, Kenneth M., additional, Wahl, Richard L., additional, and Lieberman, Frank S., additional

Published
2012
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211. Gleason Score ≤ 6 Prostate Cancer at Radical Prostatectomy: Does a High-Risk Setting Truly Exist? A Recursive Partitioning Analysis

Author

Watkins, John M., Mitchell, Darrion L., Russo, J. Kyle, Mott, Sarah L., Tracy, Chad R., Smith, Mark C., and Buatti, John M.

Abstract

Many patients with Gleason score ≤6 prostate cancer (G6PC) are observed after prostatectomy demonstrating high-risk pathologic features, owing to perceived low recurrence risk. In the present investigation, we examined 284 patients with G6PC; using a recursive partitioning analysis, a high-risk subset was identified. Specifically, the 8-year prostate-specific antigen failure rates for margin-positive versus -negative cases were 26% versus 5%, respectively.

Published
2017
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217. Kinetic Analysis of 3′-Deoxy-3′-18F-Fluorothymidine (18F-FLT) in Head and Neck Cancer Patients Before and Early After Initiation of Chemoradiation Therapy

Author

Menda, Yusuf, primary, Boles Ponto, Laura L., additional, Dornfeld, Kenneth J., additional, Tewson, Timothy J., additional, Watkins, G. Leonard, additional, Schultz, Michael K., additional, Sunderland, John J., additional, Graham, Michael M., additional, and Buatti, John M., additional

Published
2009
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225. Enhanced Response of Human Head and Neck Cancer Xenograft Tumors to Cisplatin Combined With 2-Deoxy-d-Glucose Correlates With Increased 18F-FDG Uptake as Determined by PET Imaging

Author

Simons, Andrean L., primary, Fath, Melissa A., additional, Mattson, David M., additional, Smith, Brian J., additional, Walsh, Susan A., additional, Graham, Michael M., additional, Hichwa, Richard D., additional, Buatti, John M., additional, Dornfeld, Ken, additional, and Spitz, Douglas R., additional

Published
2007
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230. Changing Failure Patterns in Oropharyngeal Squamous Cell Carcinoma Treated With Intensity Modulated Radiotherapy and Implications for Future Research

Author

Yao, Min, primary, Nguyen, Thanh, additional, Buatti, John M., additional, Dornfeld, Kenneth J., additional, Tan, Huaming, additional, Wacha, Judith, additional, Bayouth, John E., additional, Clamon, Gerald H., additional, Funk, Gerry F., additional, Smith, Russell B., additional, Chang, Kristi, additional, and Hoffman, Henry T., additional

Published
2006
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232. Serial Therapy-Induced Changes in Tumor Shape in Cervical Cancer and Their Impact on Assessing Tumor Volume and Treatment Response

Author

Mayr, Nina A., primary, Yuh, William T. C., additional, Taoka, Toshiaki, additional, Wang, Jian Z., additional, Wu, Dee H., additional, Montebello, Joseph F., additional, Meeks, Sanford L., additional, Paulino, Arnold C., additional, Magnotta, Vincent A., additional, Adli, Mustafa, additional, Sorosky, Joel I., additional, Knopp, Michael V., additional, and Buatti, John M., additional

Published
2006
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234. Optically Guided Patient Positioning Techniques

Author

Meeks, Sanford L., primary, Tomé, Wolfgang A., additional, Willoughby, Tywla R., additional, Kupelian, Patrick A., additional, Wagner, Thomas H., additional, Buatti, John M., additional, and Bova, Francis J., additional

Published
2005
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235. Merkel Cell Carcinoma

Author

Yao, Min, primary, Smith, Russell B., additional, Hoffman, Henry T., additional, Funk, Gerry F., additional, Graham, Michael M., additional, and Buatti, John M., additional

Published
2005
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247. Intracranial Ependymomas

Author

Paulino, Arnold C., primary, Wen, B.-Chen, additional, Buatti, John M., additional, Hussey, David H., additional, Zhen, Weining K., additional, Mayr, Nina A., additional, and Menezes, Arnold H., additional

Published
2002
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248. The Matrix Orthogonal Decomposition Problem in Intensity-Modulated Radiation Therapy.

Author

Chen, Danny Z., Lee, D. T., Dou, Xin, Wu, Xiaodong, Bayouth, John E., and Buatti, John M.

Abstract

In this paper, we study an interesting matrix decomposition problem that seeks to decompose a "complicated" matrix into two "simpler" matrices while minimizing the sum of the horizontal complexity of the first sub-matrix and the vertical complexity of the second sub-matrix. The matrix decomposition problem is crucial for improving the "step-and-shoot" delivery efficiency in Intensity-Modulated Radiation Therapy, which aims to deliver a highly conformal radiation dose to a target tumor while sparing the surrounding normal tissues. Our algorithm is based on a non-trivial graph construction scheme, which enables us to formulate the decomposition problem as computing a minimum s-t cut in a 3-D geometric multi-pillar graph. Experiments on randomly generated intensity map matrices and on clinical data demonstrated the efficiency of our algorithm. [ABSTRACT FROM AUTHOR]

Published
2006
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