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202. Prognostic factors for neutrophil engraftment after haploidentical cell transplantation with PT-Cy in patients with acute myeloid leukemia in complete remission, on behalf of the ALWP-EBMT

Author

Ruggeri, Annalisa, primary, Labopin, Myriam, additional, Angelucci, Emanuele, additional, Blaise, Didier, additional, Ciceri, Fabio, additional, Koc, Yener, additional, Chiusolo, Patrizia, additional, Diez-Martin, Jose Luiz, additional, Gülbas, Zafer, additional, Castagna, Luca, additional, Bruno, Benedetto, additional, Arat, Mutlu, additional, Martino, Massimo, additional, Nagler, Arnon, additional, and Mohty, Mohamad, additional

Published
2021
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203. Non-T-Cell Depleted Haploidentical Stem Cell Transplantation (haploHCT) with Post Transplantation Cyclophosphamide (PTCy)- the Role of Donor Kinship: From the ALWP of the EBMT

Author

Danylesko, Ivetta, primary, Peczynski, Christophe, additional, Labopin, Myriam, additional, Polge, Emmanuelle, additional, Tischer, Johanna, additional, Blaise, Didier, additional, Koc, Yener, additional, Gülbas, Zafer, additional, Ciceri, Fabio, additional, Arat, Mutlu, additional, Castagna, Luca, additional, Bruno, Benedetto, additional, Angelucci, Emanuele, additional, Milpied, Noel, additional, Savani, Bipin, additional, Piemontese, Simon, additional, Ruggeri, Annalisa, additional, Nagler, Arnon, additional, and Mohty, Mohamad, additional

Published
2021
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205. Addition of Rituximab in Reduced Intensity Conditioning Regimens for B-Cell Malignancies Does Not Influence Transplant Outcomes: EBMT Registry Analyses Following Allogeneic Stem Cell Transplantation for B-Cell Malignancies

Author

Tomaszewska, Agnieszka, primary, Jagasia, Madan, additional, Beohou, Eric, additional, van der Werf, Steffie, additional, Blaise, Didier, additional, Kanfer, Edward, additional, Milpied, Noel, additional, Reményi, Péter, additional, Ciceri, Fabio, additional, Bourhis, Jean H., additional, Chevallier, Patrice, additional, Solano, Carlos, additional, Socié, Gerard, additional, Bruno, Benedetto, additional, Rambaldi, Alessandro, additional, Castagna, Luca, additional, Kröger, Nicolaus, additional, Corradini, Paolo, additional, Afanasyev, Boris, additional, Ladetto, Marco, additional, Niederwieser, Dietger, additional, Scheid, Christof, additional, Sengeloev, Henrik, additional, Kroschinsky, Frank, additional, Yakoub-Agha, Ibrahim, additional, Schoemans, Helene, additional, Koenecke, Christian, additional, Penack, Olaf, additional, Perić, Zinaida, additional, Greinix, Hildegard, additional, Duarte, Rafael F., additional, and Basak, Grzegorz W., additional

Published
2021
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206. Haplotype Motif-Based Models for KIR-Genotype Informed Selection of Hematopoietic Cell Donors Fail to Predict Outcome of Patients With Myelodysplastic Syndromes or Secondary Acute Myeloid Leukemia

Author

Schetelig, Johannes, primary, Baldauf, Henning, additional, Koster, Linda, additional, Kuxhausen, Michelle, additional, Heidenreich, Falk, additional, de Wreede, Liesbeth C., additional, Spellman, Stephen, additional, van Gelder, Michel, additional, Bruno, Benedetto, additional, Onida, Francesco, additional, Lange, Vinzenz, additional, Massalski, Carolin, additional, Potter, Victoria, additional, Ljungman, Per, additional, Schaap, Nicolaas, additional, Hayden, Patrick, additional, Lee, Stephanie J., additional, Kröger, Nicolaus, additional, Hsu, Kathy, additional, Schmidt, Alexander H., additional, Yakoub-Agha, Ibrahim, additional, and Robin, Marie, additional

Published
2021
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207. Related and unrelated nonmyeloablative hematopoietic stem cell transplantation for malignant diseases

Author

Georges, George E., Maris, Michael, Sandmaier, Brenda M., Maloney, David G., LyleFeinstein, Niederweiser, Dietger, Shizuru, Judith A., McSweeney, Peter A., Chauncey, Thomas R., Agura, Edward, Little, Marie-Trse, Sahebi, Firoozeh, Hegenbart, Ute, Pulsipher, Michael A., Bruno, Benedetto, Forman, Stephen, Woolfrey, Ann E., Radich, Jerald P., Blume, Karl G., and Storb, Rainer

Published
2002
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208. Impact of second-degree related donor on the outcomes of T cell-replete haploidentical transplantation with post-transplant cyclophosphamide

Author

Mariotti, Jacopo, Raiola, Anna Maria, Evangelista, Andrea, Harbi, Samia, Patriarca, Francesca, Carella, Michele Angelo, Martino, Massimo, Risitano, Antonio, Busca, Alessandro, Giaccone, Luisa, Brunello, Lucia, Merla, Emanuela, Savino, Lucia, Loteta, Barbara, Console, Giuseppe, Fanin, Renato, Sperotto, Alessandra, Marano, Luana, Marotta, Serena, Frieri, Camilla, Sica, Simona, Chiusolo, Patrizia, Chabannon, Christian, Furst, Sabine, Santoro, Armando, Bacigalupo, Andrea, Bruno, Benedetto, Blaise, Didier, Mavilio, Domenico, Bramanti, Stefania, Devillier, Raynier, Angelucci, Emanuele, and Castagna, Luca

Abstract

Donor selection may contribute to improve clinical outcomes of T cell-replete haploidentical stem cell transplantation (Haplo-SCT) with post-transplant cyclophosphamide (PT-Cy). Impact of second-degree related donor (SRD) was not fully elucidated in this platform. We retrospectively compared the outcome of patients receiving Haplo-SCT either from a SRD (n= 31) or a first-degree related donor (FRD, n= 957). Median time to neutrophil and platelet recovery did not differ between a SRD and a FRD transplant (p= 0.599 and 0.587). Cumulative incidence of grade II–IV acute graft-versus host disease (GVHD) and moderate-severe chronic GVHD was 13% and 19% after SRD vs 24% (p= 0.126) and 13% (p= 0.395) after FRD transplant. One-year cumulative incidence of non-relapse mortality (NRM) was 19% for SRD and 20% for FRD (p= 0.435) cohort. The 3-year probability of overall survival (OS) and progression-free survival (PFS) was 42% vs 55% (p= 0.273) and 49% vs 35% (p= 0.280) after SRD and FRD transplant, respectively. After propensity score adjustment or matched pair analysis, the outcome of patients receiving Haplo-SCT from a SRD or a FRD did not differ in terms of NRM, OS, PFS, acute and chronic GVHD. Our results suggest that a SRD is a viable option for Haplo-SCT with PT-Cy when a FRD is not available.

Published
2022
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210. Unrelated Donor Granulocyte Colony-Stimulating Factor–Mobilized Peripheral Blood Mononuclear Cell Transplantation after Nonmyeloablative Conditioning: The Effect of Postgrafting Mycophenolate Mofetil Dosing

Author

Maris, Michael B., Sandmaier, Brenda M., Storer, Barry E., Maloney, David G., Shizuru, Judith A., Agura, Edward, Kliem, Constanze, Pulsipher, Michael, Maziarz, Richard T., McSweeney, Peter A., Wade, James, Langston, Amelia A., Chauncey, Thomas R., Bruno, Benedetto, Blume, Karl G., and Storb, Rainer

Published
2006
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212. Long-term Outcomes Among Older Patients Following Nonmyeloablative Conditioning and Allogeneic Hematopoietic Cell Transplantation for Advanced Hematologic Malignancies

Author

Sorror, Mohamed L., Sandmaier, Brenda M., Storer, Barry E., Franke, Georg N., Laport, Ginna G., Chauncey, Thomas R., Agura, Edward, Maziarz, Richard T., Langston, Amelia, Hari, Parameswaran, Pulsipher, Michael A., Bethge, Wolfgang, Sahebi, Firoozeh, Bruno, Benedetto, Maris, Michael B., Yeager, Andrew, Petersen, Finn Bo, Vindeløv, Lars, McSweeney, Peter A., Hübel, Kai, Mielcarek, Marco, Georges, George E., Niederwieser, Dietger, Blume, Karl G., Maloney, David G., and Storb, Rainer

Published
2011
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213. Biomarkers for acute and chronic graft versus host disease: state of the art

Author

Giaccone, Luisa, primary, Faraci, Danilo Giuseppe, additional, Butera, Sara, additional, Lia, Giuseppe, additional, Di Vito, Clara, additional, Gabrielli, Giulia, additional, Cerrano, Marco, additional, Mariotti, Jacopo, additional, Dellacasa, Chiara, additional, Felicetti, Francesco, additional, Brignardello, Enrico, additional, Mavilio, Domenico, additional, and Bruno, Benedetto, additional

Published
2020
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214. Personalized Risk-Profiling for Acute Leukemia Patients Undergoing Haploidentical Allogeneic Hematopoietic Stem Cell Transplantation: A Study on Behalf of the Acute Leukemia Working Party of the EBMT

Author

Fein, Joshua A, primary, Shouval, Roni, additional, Labopin, Myriam, additional, Ciceri, Fabio, additional, Angelucci, Emanuele, additional, Blaise, Didier, additional, Tischer, Johanna, additional, Arcese, William, additional, Koc, Yener, additional, Bruno, Benedetto, additional, Diez-Martin, Jose L., additional, Santarone, Stella, additional, Sica, Simona, additional, Versluis, Jurjen, additional, Mohty, Mohamad, additional, and Nagler, Arnon, additional

Published
2020
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215. Use of Post-Transplant Cyclophosphamide in One-Antigen Mismatched Unrelated Donor Transplantation Results in Similar Transplant Outcomes Than Haploidentical Hransplantation: A Retrospective Study on Behalf of the Acute Leukemia Working Party of the EBMT

Author

Battipaglia, Giorgia, primary, Galimard, Jacques-Emmanuel, additional, Labopin, Myriam, additional, Angelucci, Emanuele, additional, Blaise, Didier, additional, Ruggeri, Annalisa, additional, Gulbas, Zafer, additional, Díez-Martín, José Luis, additional, Koc, Yener, additional, Castagna, Luca, additional, Vitek, Antonin, additional, Sica, Simona, additional, Bruno, Benedetto, additional, Moiseev, Ivan S., additional, Rovira, Montserrat, additional, Martino, Massimo, additional, Araujo, Mercedes Colorado, additional, Arat, Mutlu, additional, Grillo, Giovanni, additional, Martin, Hans, additional, Corral, Lucía López, additional, Pane, Fabrizio, additional, Ciceri, Fabio, additional, Nagler, Arnon, additional, and Mohty, Mohamad, additional

Published
2020
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216. Reduced Intensity Vs. Non-Myeloablative Conditioning Regimens for Haploidentical Transplantation in Complete Remission Acute Myeloid Leukemia: A Study from the ALWP of the EBMT

Author

Devillier, Raynier, primary, Galimard, Jacques-Emmanuel, additional, Labopin, Myriam, additional, Blaise, Didier, additional, Angelucci, Emanuele, additional, Castagna, Luca, additional, Pavlu, Jiri, additional, Socie, Gerard, additional, Martino, Massimo, additional, Stoelzel, Friedrich, additional, Bug, Gesine, additional, Chalandon, Yves, additional, Bruno, Benedetto, additional, Potter, Victoria, additional, Brissot, Eolia, additional, Savani, Bipin N., additional, Nagler, Arnon, additional, and Mohty, Mohamad, additional

Published
2020
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218. Donor Lymphocyte Infusions After Allogeneic Stem Cell Transplantation in Acute Leukemia: A Survey From the Gruppo Italiano Trapianto Midollo Osseo (GITMO)

Author

Patriarca, Francesca, primary, Sperotto, Alessandra, additional, Lorentino, Francesca, additional, Oldani, Elena, additional, Mammoliti, Sonia, additional, Isola, Miriam, additional, Picardi, Alessandra, additional, Arcese, William, additional, Saporiti, Giorgia, additional, Sorasio, Roberto, additional, Mordini, Nicola, additional, Cavattoni, Irene, additional, Musso, Maurizio, additional, Borghero, Carlo, additional, Micò, Caterina, additional, Fanin, Renato, additional, Bruno, Benedetto, additional, Ciceri, Fabio, additional, and Bonifazi, Francesca, additional

Published
2020
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219. Timing of Post-Transplantation Cyclophosphamide Administration in Haploidentical Transplantation: A Comparative Study on Behalf of the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation

Author

Ruggeri, Annalisa, primary, Labopin, Myriam, additional, Battipaglia, Giorgia, additional, Chiusolo, Patrizia, additional, Tischer, Johanna, additional, Diez-Martin, Jean Luiz, additional, Bruno, Benedetto, additional, Castagna, Luca, additional, Moiseev, Ivan Sergeevich, additional, Vitek, Antonin, additional, Rovira, Montserrat, additional, Ciceri, Fabio, additional, Bacigalupo, Andrea, additional, Nagler, Arnon, additional, and Mohty, Mohamad, additional

Published
2020
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220. Impact of donor age and kinship on clinical outcomes after T-cell–replete haploidentical transplantation with PT-Cy

Author

Mariotti, Jacopo, primary, Raiola, Anna Maria, additional, Evangelista, Andrea, additional, Carella, Angelo Michele, additional, Martino, Massimo, additional, Patriarca, Francesca, additional, Risitano, Antonio, additional, Bramanti, Stefania, additional, Busca, Alessandro, additional, Giaccone, Luisa, additional, Brunello, Lucia, additional, Merla, Emanuela, additional, Savino, Lucia, additional, Loteta, Barbara, additional, Console, Giuseppe, additional, Fanin, Renato, additional, Sperotto, Alessandra, additional, Marano, Luana, additional, Marotta, Serena, additional, Frieri, Camilla, additional, Sica, Simona, additional, Chiusolo, Patrizia, additional, Harbi, Samia, additional, Furst, Sabine, additional, Santoro, Armando, additional, Bacigalupo, Andrea, additional, Blaise, Didier, additional, Angelucci, Emanuele, additional, Mavilio, Domenico, additional, Castagna, Luca, additional, and Bruno, Benedetto, additional

Published
2020
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221. Impact of total body irradiation‐ vs chemotherapy‐based myeloablative conditioning on outcomes of haploidentical hematopoietic cell transplantation for acute myelogenous leukemia

Author

Dholaria, Bhagirathbhai, primary, Labopin, Myriam, additional, Angelucci, Emanuele, additional, Ciceri, Fabio, additional, Diez‐Martin, Jose L., additional, Bruno, Benedetto, additional, Sica, Simona, additional, Koc, Yener, additional, Gülbas, Zafer, additional, Schmid, Christoph, additional, Blaise, Didier, additional, Carella, Angelo Michele, additional, Visani, Guiseppe, additional, Savani, Bipin N., additional, Nagler, Arnon, additional, and Mohty, Mohamad, additional

Published
2020
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222. Immunomodulatory and clinical effects of daratumumab in T‐cell acute lymphoblastic leukaemia

Author

Cerrano, Marco, primary, Castella, Barbara, additional, Lia, Giuseppe, additional, Olivi, Matteo, additional, Faraci, Danilo G., additional, Butera, Sara, additional, Martella, Federica, additional, Scaldaferri, Matilde, additional, Cattel, Francesco, additional, Boccadoro, Mario, additional, Massaia, Massimo, additional, Ferrero, Dario, additional, Bruno, Benedetto, additional, and Giaccone, Luisa, additional

Published
2020
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223. Organ Stiffness in the Work-Up of Myelofibrosis and Philadelphia-Negative Chronic Myeloproliferative Neoplasms

Author

Benedetti, Edoardo, primary, Tavarozzi, Rita, additional, Morganti, Riccardo, additional, Bruno, Benedetto, additional, Bramanti, Emilia, additional, Baratè, Claudia, additional, Balducci, Serena, additional, Iovino, Lorenzo, additional, Ricci, Federica, additional, Ricchiuto, Vittorio, additional, Buda, Gabriele, additional, and Galimberti, Sara, additional

Published
2020
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224. The outcome of two or more HLA loci mismatched unrelated donor hematopoietic cell transplantation for acute leukemia: an ALWP of the EBMT study

Author

Nagler, Arnon, primary, Dholaria, Bhagirathbhai, additional, Labopin, Myriam, additional, Bruno, Benedetto, additional, Rambaldi, Alessandro, additional, Pioltelli, Pietro, additional, La Nasa, Giorgio, additional, Socié, Gerard, additional, Mielke, Stephan, additional, Ruggeri, Marco, additional, Saccardi, Riccardo, additional, Franke, Georg-Nikolaus, additional, Finke, Jürgen, additional, Savani, Bipin N., additional, Ruggeri, Annalisa, additional, and Mohty, Mohamad, additional

Published
2020
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225. The Advent of CAR T-Cell Therapy for Lymphoproliferative Neoplasms: Integrating Research Into Clinical Practice

Author

Cerrano, Marco, primary, Ruella, Marco, additional, Perales, Miguel-Angel, additional, Vitale, Candida, additional, Faraci, Danilo Giuseppe, additional, Giaccone, Luisa, additional, Coscia, Marta, additional, Maloy, Molly, additional, Sanchez-Escamilla, Miriam, additional, Elsabah, Hesham, additional, Fadul, Afraa, additional, Maffini, Enrico, additional, Pittari, Gianfranco, additional, and Bruno, Benedetto, additional

Published
2020
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226. Effect of the Thiotepa Dose in the TBF Conditioning Regimen in Patients Undergoing Allogeneic Stem Cell Transplantation for Acute Myeloid Leukemia in Complete Remission: A Report From the EBMT Acute Leukemia Working Party

Author

El-Cheikh, Jean, primary, Labopin, Myriam, additional, Al-Chami, Farouk, additional, Bazarbachi, Ali, additional, Angelucci, Emanuele, additional, Santarone, Stella, additional, Bonifazi, Francesca, additional, Carella, Angelo Michele, additional, Castagna, Luca, additional, Bruno, Benedetto, additional, Iori, Anna Paola, additional, La Nasa, Giorgio, additional, Savani, Bipin, additional, Nagler, Arnon, additional, and Mohty, Mohamad, additional

Published
2020
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227. Long-term survival of 1338 MM patients treated with tandem autologous vs. autologous-allogeneic transplantation

Author

Costa, Luciano J., primary, Iacobelli, Simona, additional, Pasquini, Marcelo C., additional, Modi, Riddhi, additional, Giaccone, Luisa, additional, Blade, Joan, additional, Schonland, Stefan, additional, Evangelista, Andrea, additional, Perez-Simon, Jose A., additional, Hari, Parameswaran, additional, Brown, Elizabeth E., additional, Giralt, Sergio A., additional, Patriarca, Francesca, additional, Stadtmauer, Edward A., additional, Rosinol, Laura, additional, Krishnan, Amrita Y., additional, Gahrton, Gösta, additional, and Bruno, Benedetto, additional

Published
2020
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228. Allogeneic Hemopoietic Stem Cell Transplants in Patients with Acute Myeloid Leukemia (AML) Prepared with Busulfan and Fludarabine (BUFLU) or Thiotepa, Busulfan, and Fludarabine (TBF): A Retrospective Study

Author

Sora, Federica, primary, Grazia, Carmen Di, additional, Chiusolo, Patrizia, additional, Raiola, Anna Maria, additional, Bregante, Stefania, additional, Mordini, Nicola, additional, Olivieri, Attilio, additional, Iori, Anna Paola, additional, Patriarca, Francesca, additional, Grisariu, Sigal, additional, Terruzzi, Elisabetta, additional, Rambaldi, Alessandro, additional, Sica, Simona, additional, Bruno, Benedetto, additional, Angelucci, Emanuele, additional, and Bacigalupo, Andrea, additional

Published
2020
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230. Outcomes of Acute Myelogenous Leukemia Patients Undergoing Haploidentical Hematopoietic Cell Transplantation with Post-Transplant Cyclophosphamide: Impact of Total Body Irradiation Versus Chemotherapy-Based Myeloablative Conditioning

Author

Dholaria, Bhagirathbhai, primary, Labopin, Myriam, additional, Angelucci, Emanuele, additional, Ciceri, Fabio, additional, Diez-Martin, José Luis, additional, Bruno, Benedetto, additional, Sica, Simona, additional, Koc, Yener, additional, Gulbas, Zafer, additional, Schmid, Christoph, additional, Blaise, Didier, additional, Carella, Angelo, additional, Visani, Giuseppe, additional, Savani, Bipin, additional, Nagler, Arnon, additional, and Mohty, Mohamad, additional

Published
2020
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231. Allogeneic Stem Cell Transplantation from Two Loci Mismatched (≤6/8) Unrelated Donors in Acute Leukemia: On Behalf of the ALWP of the EBMT

Author

Nagler, Arnon, primary, Labopin, Myriam, additional, Bruno, Benedetto, additional, Rambaldi, Alessandro, additional, Pioltelli, Pietro, additional, la Nasa, Giorgio, additional, Socié, Gerard, additional, Mielke, Stephan, additional, Ruggeri, Marco, additional, Saccardi, Riccardo, additional, Platzbecker, Uwe, additional, Finke, Jürgen, additional, Ruggeri, Annalisa, additional, Savani, Bipin, additional, and Mohty, Mohamad, additional

Published
2020
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232. Antiemetic prophylaxis in patients undergoing hematopoietic stem cell transplantation: a multicenter survey of the Gruppo Italiano Trapianto Midollo Osseo (GITMO) transplant programs

Author

Pastore, Domenico, primary, Bruno, Benedetto, additional, Carluccio, Paola, additional, De Candia, Maria Stella, additional, Mammoliti, Sonia, additional, Borghero, Carlo, additional, Chierichini, Anna, additional, Pavan, Fabio, additional, Casini, Marco, additional, Pini, Massimo, additional, Nassi, Luca, additional, Greco, Raffaella, additional, Tambaro, Francesco Paolo, additional, Stefanoni, Paola, additional, Console, Giuseppe, additional, Marchesi, Francesco, additional, Facchini, Luca, additional, Mussetti, Alberto, additional, Cimminiello, Michele, additional, Saglio, Francesco, additional, Vincenti, Daniele, additional, Falcioni, Sadia, additional, Chiusolo, Patrizia, additional, Olivieri, Jacopo, additional, Natale, Annalisa, additional, Faraci, Maura, additional, Cesaro, Simone, additional, Marotta, Serena, additional, Proia, Anna, additional, Donnini, Irene, additional, Caravelli, Daniela, additional, Zuffa, Eliana, additional, Iori, Anna Paola, additional, Soncini, Elena, additional, Bozzoli, Valentina, additional, Pisapia, Giovanni, additional, Scalone, Renato, additional, Villani, Oreste, additional, Prete, Arcangelo, additional, Ferrari, Antonella, additional, Menconi, Mariacristina, additional, Mancini, Giorgia, additional, Gigli, Federica, additional, Gargiulo, Gianpaolo, additional, Bruno, Barbara, additional, Patriarca, Francesca, additional, and Bonifazi, Francesca, additional

Published
2020
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234. CMV retinitis in a stem cell transplant recipient treated with foscarnet intravitreal injection and CMV specific immunoglobulins

Author

Vassallo, Francesco, primary, Nuzzi, Raffaele, additional, Cattani, Ilaria, additional, Dellacasa, Chiara, additional, Giaccone, Luisa, additional, De Rosa, Francesco Giuseppe, additional, Cavallo, Rossana, additional, Iovino, Giorgia, additional, Brunello, Lucia, additional, Bruno, Benedetto, additional, and Busca, Alessandro, additional

Published
2020
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236. Bone marrow versus mobilized peripheral blood stem cells in haploidentical transplants using posttransplantation cyclophosphamide

Author

Ruggeri, Annalisa, Labopin, Myriam, Bacigalupo, Andrea, Gülbas, Zafer, Koc, Yener, Blaise, Didier, Bruno, Benedetto, Irrera, Giuseppe, Tischer, Johanna, Diez-Martin, Jose Luiz, Castagna, Luca, Ciceri, Fabio, Mohty, Mohamad, Nagler, Arnon, Ruggeri, Annalisa, Labopin, Myriam, Bacigalupo, Andrea, Gülbas, Zafer, Koc, Yener, Blaise, Didier, Bruno, Benedetto, Irrera, Giuseppe, Tischer, Johanna, Diez-Martin, Jose Luiz, Castagna, Luca, Ciceri, Fabio, Mohty, Mohamad, and Nagler, Arnon

Subjects
Adult, Male, Cancer Research, Transplantation Conditioning, Adolescent, Haploidentical transplantation, Stem cell source, Graft vs Host Disease, Posttransplantation cyclophosphamide, Young Adult, Humans, acute graft-versus-host disease, acute leukemia, haploidentical transplantation, posttransplantation cyclophosphamide, stem cell source, Cyclophosphamide, Aged, Bone Marrow Transplantation, Retrospective Studies, Peripheral Blood Stem Cell Transplantation, Acute leukemia, Acute graft-versus-host disease, Middle Aged, Myeloablative Agonists, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Prognosis, Combined Modality Therapy, Survival Rate, Leukemia, Myeloid, Acute, Oncology, Transplantation, Haploidentical, Female, Follow-Up Studies
Abstract

BACKGROUND: Incidence of graft-versus-host disease (GVHD) in haploidentical bone marrow (BM) transplants using posttransplantion cyclophosphamide (PT-Cy) is low, whereas GVHD using mobilized peripheral blood stem cells (PBSC) ranges between 30% and 40%. METHODS: To evaluate the effect of stem cell source in haploidentical transplantation with PT-Cy, we analyzed 451 patients transplanted for acute myeloid leukemia or acute lymphoblastic leukemia reported to the European Society for Blood and Marrow Transplantation. RESULTS: BM was used in 260 patients, and PBSC were used in 191 patients. The median follow-up was 21 months. Engraftment was lower in BM (92% vs 95%, P < 0.001). BM was associated with a lower incidence of stage II-IV and stage III-IV acute GVHD (21% vs 38%, P ≤ .01; and 4% vs 14%, P < .01, respectively). No difference in chronic GVHD, relapse, or nonrelapse mortality were found for PBSC or BM. The 2-year overall survival (OS) was 55% versus 56% (P = .57) and leukemia-free survival (LFS) was 49% versus 54% (P = .74) for BM and PBSC, respectively. On multivariate analysis, PBSC were associated with an increased risk of stage II-IV (hazard ratio [HR], 2.1; P < .001) and stage III-IV acute GVHD (HR, 3.8; P < .001). For LFS and OS, reduced intensity conditioning was the only factor associated with treatment failure (LFS: HR, 1.40; P = .04) and relapse (HR, 1.62; P = .02). CONCLUSION: In patients with acute leukemia in first or second remission receiving haploidentical transplantation with PT-Cy, the use of PBSC increases the risk of acute GVHD, whereas survival outcomes are comparable.

Published
2018
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238. Reduced intensity versus non-myeloablative conditioning regimen for haploidentical transplantation and post-transplantation cyclophosphamide in complete remission acute myeloid leukemia: a study from the ALWP of the EBMT

Author

Devillier, Raynier, Galimard, Jacques-Emmanuel, Labopin, Myriam, Blaise, Didier, Raiola, Anna Maria, Pavlu, Jiri, Castagna, Luca, Socié, Gerard, Chalandon, Yves, Martino, Massimo, Stölzel, Friedrich, Bug, Gesine, Bruno, Benedetto, Vrhovac, Radovan, Charbonnier, Amandine, Olivieri, Attilio, Bay, Jacques-Olivier, Arroyo, Herrera, Yakoub-Agha, Ibrahim, Avenoso, Daniele, Neubauer, Andreas, Nguyen, Stéphanie, Forcade, Edouard, Brissot, Eolia, Savani, Bipin, Nagler, Arnon, and Mohty, Mohamad

Abstract

The optimal conditioning regimen prior haploidentical stem cell transplantation (Haplo-SCT) with post transplantation cyclophosphamide (PT-Cy) for acute myeloid leukemia (AML) remains unknown. A non-myeloablative conditioning (NMAC) regimen (cyclophosphamide + fludarabine + TBI 2 Gy [CyFluTBI]) is a safe approach, but relapse incidence remains high in this setting. Alternatively, a reduced intensity conditioning (RIC) regimen combining thiotepa and reduced-dose busulfan with fludarabine (TBF) may decrease AML relapse. However, an excess of toxicity may counterbalance this potential benefit. We retrospectively compared CyFluTBI vs. TBF in CR AML patients who underwent Haplo-SCT with PT-Cy, in two different populations based on age. We analyzed 490 patients. In patients aged <60 years (n= 203), we observed a higher RI (HR = 3.59, 95% CI = 1.75–7.37, p< 0.01), lower LFS (HR = 1.98, 95% CI = 1.22–3.22, p< 0.01) and lower OS (HR = 1.73, 95% CI = 1.04–2.88, p= 0.04) in the CyFluTBI group, without significant difference in NRM. In older patients (n= 287), we observed that conditioning regimen did not significantly influence LFS (HR = 0.90, 95% CI = 0.56–1.44, p= 0.65), OS (HR = 0.81, 95% CI = 0.49–1.32, p= 0.39) and RI (HR = 1.78, 95% CI = 0.90–3.50, p= 0.10), but showed that CyFluTBI was associated with a significantly lower risk of NRM (HR = 0.48, 95% CI = 0.25–0.92, p= 0.03). Thus, younger patients seem to benefit from conditioning intensification from CyFluTBI to TBF regimens prior PT-Cy Haplo-SCT for CR AML, while older ones do not.

Published
2022
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239. Multiple Myeloma

Author

Joan, Bladé, Bruno, Benedetto, and Mohamad, Mohty.

Subjects
Multiple myeloma
Published
2019

240. Additional file 2: of Leukemia relapse following unmanipulated haploidentical transplantation: a risk factor analysis on behalf of the ALWP of the EBMT

Author

Piemontese, Simona, Boumendil, Ariane, Labopin, Myriam, Schmid, Christoph, Ciceri, Fabio, Arcese, William, Koc, Yener, Gulbas, Zafar, Tischer, Johanna, Bruno, Benedetto, Depei Wu, Blaise, Didier, Beelen, Dietrich, Irrera, Giuseppe, Ruggeri, Annalisa, Houhou, Mohamed, Mohty, Mohamad, and Nagler, Arnon

Abstract

Table S2. Characteristics of relapsed patients. (DOCX 25 kb)

Published
2019
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241. Additional file 3: of Leukemia relapse following unmanipulated haploidentical transplantation: a risk factor analysis on behalf of the ALWP of the EBMT

Author

Piemontese, Simona, Boumendil, Ariane, Labopin, Myriam, Schmid, Christoph, Ciceri, Fabio, Arcese, William, Koc, Yener, Gulbas, Zafar, Tischer, Johanna, Bruno, Benedetto, Depei Wu, Blaise, Didier, Beelen, Dietrich, Irrera, Giuseppe, Ruggeri, Annalisa, Houhou, Mohamed, Mohty, Mohamad, and Nagler, Arnon

Abstract

Table S3. Univariate analysis for RI in ALL and AML. (DOCX 21 kb)

Published
2019
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242. Additional file 1: of Leukemia relapse following unmanipulated haploidentical transplantation: a risk factor analysis on behalf of the ALWP of the EBMT

Author

Piemontese, Simona, Boumendil, Ariane, Labopin, Myriam, Schmid, Christoph, Ciceri, Fabio, Arcese, William, Koc, Yener, Gulbas, Zafar, Tischer, Johanna, Bruno, Benedetto, Depei Wu, Blaise, Didier, Beelen, Dietrich, Irrera, Giuseppe, Ruggeri, Annalisa, Houhou, Mohamed, Mohty, Mohamad, and Nagler, Arnon

Abstract

Table S1. Characteristic of the 587 patients included in our analysis and the 1065 patients transplanted in the same years in the EBMT centres but not included in the final analysis due to incomplete data. (DOCX 19 kb)

Published
2019
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243. Additional file 5: of Leukemia relapse following unmanipulated haploidentical transplantation: a risk factor analysis on behalf of the ALWP of the EBMT

Author

Piemontese, Simona, Boumendil, Ariane, Labopin, Myriam, Schmid, Christoph, Ciceri, Fabio, Arcese, William, Koc, Yener, Gulbas, Zafar, Tischer, Johanna, Bruno, Benedetto, Depei Wu, Blaise, Didier, Beelen, Dietrich, Irrera, Giuseppe, Ruggeri, Annalisa, Houhou, Mohamed, Mohty, Mohamad, and Nagler, Arnon

Abstract

Table S5. EBMT participating centers. (DOCX 20 kb)

Published
2019
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247. Unrelated donor haematopoietic cell transplantation after non-myeloablative conditioning for patients with high-risk multiple myeloma

Author

Bruno, Benedetto, Sorasio, Roberto, Patriarca, Francesca, Montefusco, Vittorio, Guidi, Stefano, Busca, Alessandro, Scimé, Rosanna, Console, Giuseppe, Milone, Giuseppe, Marotta, Giuseppe, Dominietto, Alida, Giaccone, Luisa, Rotta, Marcello, Falda, Michele, Bacigalupo, Andrea, Bosi, Alberto, Corradini, Paolo, Fanin, Renato, Pollichieni, Simona, and Boccadoro, Mario

Published
2007

248. European Myeloma Network Guidelines for the Management of Multiple Myeloma-related Complications

Author

Terpos, Evangelos, Kleber, Martina, Engelhardt, Monika, Zweegman, Sonja, Gay, Francesca, Kastritis, Efstathios, van de Donk, Niels W C J, Bruno, Benedetto, Sezer, Orhan, Broijl, Annemiek, Bringhen, Sara, Beksac, Meral, Larocca, Alessandra, Hajek, Roman, Musto, Pellegrino, Johnsen, Hans Erik, Morabito, Fortunato, Ludwig, Heinz, Cavo, Michele, Einsele, Hermann, Sonneveld, Pieter, Dimopoulos, Meletios A, Palumbo, Antonio, Hematology, CCA - Innovative therapy, European Myeloma Network, Radiology & Nuclear Medicine, Terpos, Evangelo, Kleber, Martina, Engelhardt, Monika, Zweegman, Sonja, Gay, Francesca, Kastritis, Efstathio, van de Donk, Niels W C J, Bruno, Benedetto, Sezer, Orhan, Broijl, Annemiek, Bringhen, Sara, Beksac, Meral, Larocca, Alessandra, Hajek, Roman, Musto, Pellegrino, Johnsen, Hans Erik, Morabito, Fortunato, Ludwig, Heinz, Cavo, Michele, Einsele, Hermann, Sonneveld, Pieter, Dimopoulos, Meletios A, and Palumbo, Antonio

Subjects
medicine.medical_specialty, Bone disease, Anemia, Infections, Asymptomatic, Guideline Article, SDG 3 - Good Health and Well-being, Internal medicine, medicine, Humans, Pain Management, ddc:610, Multiple myeloma, European Myeloma Network, recommendations, Hematology, business.industry, Bortezomib, Disease Management, Peripheral Nervous System Diseases, Venous Thromboembolism, medicine.disease, Surgery, Zoledronic acid, Kidney Diseases, medicine.symptom, Bone Diseases, business, Multiple Myeloma, Hemophilus, medicine.drug
Abstract

The European Myeloma Network provides recommendations for the management of the most common complications of multiple myeloma. Whole body low-dose computed tomography is more sensitive than conventional radiography in depicting osteolytic disease and thus we recommend it as the novel standard for the detection of lytic lesions in myeloma (grade 1A). Myeloma patients with adequate renal function and bone disease at diagnosis should be treated with zoledronic acid or pamidronate (grade 1A). Symptomatic patients without lytic lesions on conventional radiography can be treated with zoledronic acid (grade 1B), but its advantage is not clear for patients with no bone involvement on computed tomography or magnetic resonance imaging. In asymptomatic myeloma, bisphosphonates are not recommended (grade 1A). Zoledronic acid should be given continuously, but it is not clear if patients who achieve at least a very good partial response benefit from its continuous use (grade 1B). Treatment with erythropoietic-stimulating agents may be initiated in patients with persistent symptomatic anemia (hemoglobin

Published
2015
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249. Factors Associated With Outcomes in Allogeneic Hematopoietic Cell Transplantation With Nonmyeloablative Conditioning After Failed Myeloablative Hematopoietic Cell Transplantation

Author

Baron, Frédéric, Storb, Rainer, Storer, Barry E., Maris, Michael B., Niederwieser, Dietger, Shizuru, Judith A., Chauncey, Thomas R., Bruno, Benedetto, Forman, Stephen J., McSweeney, Peter A., Maziarz, Richard T., Pulsipher, Michael A., Agura, Edward D., Wade, James, Sorror, Mohamed, Maloney, David G., and Sandmaier, Brenda M.

Published
2006
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250. Time to first disease progression, but not (beta)2-microglobulin, predicts outcome in myeloma patients who receive thalidomide as salvage therapy

Author

Palumbo, Antonio, Bringhen, Sara, Falco, Patrizia, Cavallo, Federica, Ambrosini, Maria Teresa, Avonto, Ilaria, Gay, Francesca, Caravita, Tommaso, Bruno, Benedetto, and Boccadoro, Mario

Subjects
Prognosis -- Research, Outcome and process assessment (Health Care) -- Research, Thalidomide -- Dosage and administration, Beta globulins -- Physiological aspects, Multiple myeloma -- Patient outcomes, Multiple myeloma -- Development and progression, Multiple myeloma -- Diagnosis, Multiple myeloma -- Care and treatment, Health
Published
2007

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