765 results on '"Brumpton, Ben"'
Search Results
202. Asthma, asthma control and risk of ischemic stroke: The HUNT study
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Cepelis, Aivaras, primary, Brumpton, Ben M., additional, Laugsand, Lars E., additional, Langhammer, Arnulf, additional, Janszky, Imre, additional, and Strand, Linn B., additional
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- 2020
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203. Parallel gradients in FENO and in the prevalences of asthma and atopy in adult general populations of Sweden, Finland and Estonia — A Nordic EpiLung study
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Lassmann-Klee, Paul G., primary, Piirilä, Päivi L., additional, Brumpton, Ben, additional, Larsson, Matz, additional, Sundblad, Britt-Marie, additional, Põlluste, Jaak, additional, Juusela, Maria, additional, Rouhos, Annamari, additional, Meren, Mari, additional, Lindqvist, Ari, additional, Kankaanranta, Hannu, additional, Backman, Helena, additional, Langhammer, Arnulf, additional, Rönmark, Eva, additional, Lundbäck, Bo, additional, and Sovijärvi, Anssi R.A., additional
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- 2020
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204. Genome-wide association study of over 40,000 bipolar disorder cases provides new insights into the underlying biology
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Mullins, Niamh, primary, Forstner, Andreas J., additional, O’Connell, Kevin S., additional, Coombes, Brandon, additional, Coleman, Jonathan R. I., additional, Qiao, Zhen, additional, Als, Thomas D., additional, Bigdeli, Tim B., additional, Børte, Sigrid, additional, Bryois, Julien, additional, Charney, Alexander W., additional, Drange, Ole Kristian, additional, Gandal, Michael J., additional, Hagenaars, Saskia P., additional, Ikeda, Masashi, additional, Kamitaki, Nolan, additional, Kim, Minsoo, additional, Krebs, Kristi, additional, Panagiotaropoulou, Georgia, additional, Schilder, Brian M., additional, Sloofman, Laura G., additional, Steinberg, Stacy, additional, Trubetskoy, Vassily, additional, Winsvold, Bendik S., additional, Won, Hong-Hee, additional, Abramova, Liliya, additional, Adorjan, Kristina, additional, Agerbo, Esben, additional, Al Eissa, Mariam, additional, Albani, Diego, additional, Alliey-Rodriguez, Ney, additional, Anjorin, Adebayo, additional, Antilla, Verneri, additional, Antoniou, Anastasia, additional, Awasthi, Swapnil, additional, Baek, Ji Hyun, additional, Bækvad-Hansen, Marie, additional, Bass, Nicholas, additional, Bauer, Michael, additional, Beins, Eva C., additional, Bergen, Sarah E., additional, Birner, Armin, additional, Bøcker Pedersen, Carsten, additional, Bøen, Erlend, additional, Boks, Marco P., additional, Bosch, Rosa, additional, Brum, Murielle, additional, Brumpton, Ben M., additional, Brunkhorst-Kanaan, Nathalie, additional, Budde, Monika, additional, Bybjerg-Grauholm, Jonas, additional, Byerley, William, additional, Cairns, Murray, additional, Casas, Miquel, additional, Cervantes, Pablo, additional, Clarke, Toni-Kim, additional, Cruceanu, Cristiana, additional, Cuellar-Barboza, Alfredo, additional, Cunningham, Julie, additional, Curtis, David, additional, Czerski, Piotr M., additional, Dale, Anders M., additional, Dalkner, Nina, additional, David, Friederike S., additional, Degenhardt, Franziska, additional, Djurovic, Srdjan, additional, Dobbyn, Amanda L., additional, Douzenis, Athanassios, additional, Elvsåshagen, Torbjørn, additional, Escott-Price, Valentina, additional, Ferrier, I. Nicol, additional, Fiorentino, Alessia, additional, Foroud, Tatiana M., additional, Forty, Liz, additional, Frank, Josef, additional, Frei, Oleksandr, additional, Freimer, Nelson B., additional, Frisén, Louise, additional, Gade, Katrin, additional, Garnham, Julie, additional, Gelernter, Joel, additional, Giørtz Pedersen, Marianne, additional, Gizer, Ian R., additional, Gordon, Scott D., additional, Gordon-Smith, Katherine, additional, Greenwood, Tiffany A., additional, Grove, Jakob, additional, Guzman-Parra, José, additional, Ha, Kyooseob, additional, Haraldsson, Magnus, additional, Hautzinger, Martin, additional, Heilbronner, Urs, additional, Hellgren, Dennis, additional, Herms, Stefan, additional, Hoffmann, Per, additional, Holmans, Peter A., additional, Huckins, Laura, additional, Jamain, Stéphane, additional, Johnson, Jessica S., additional, Kalman, Janos L., additional, Kamatani, Yoichiro, additional, Kennedy, James L., additional, Kittel-Schneider, Sarah, additional, Knowles, James A., additional, Kogevinas, Manolis, additional, Koromina, Maria, additional, Kranz, Thorsten M., additional, Kranzler, Henry R., additional, Kubo, Michiaki, additional, Kupka, Ralph, additional, Kushner, Steven A., additional, Lavebratt, Catharina, additional, Lawrence, Jacob, additional, Leber, Markus, additional, Lee, Heon-Jeong, additional, Lee, Phil H., additional, Levy, Shawn E., additional, Lewis, Catrin, additional, Liao, Calwing, additional, Lucae, Susanne, additional, Lundberg, Martin, additional, MacIntyre, Donald J., additional, Magnusson, Sigurdur H., additional, Maier, Wolfgang, additional, Maihofer, Adam, additional, Malaspina, Dolores, additional, Maratou, Eirini, additional, Martinsson, Lina, additional, Mattheisen, Manuel, additional, McCarroll, Steven A., additional, McGregor, Nathaniel W., additional, McGuffin, Peter, additional, McKay, James D., additional, Medeiros, Helena, additional, Medland, Sarah E., additional, Millischer, Vincent, additional, Montgomery, Grant W., additional, Moran, Jennifer L., additional, Morris, Derek W., additional, Mühleisen, Thomas W., additional, O’Brien, Niamh, additional, O’Donovan, Claire, additional, Loohuis, Loes M. Olde, additional, Oruc, Lilijana, additional, Papiol, Sergi, additional, Pardiñas, Antonio F., additional, Perry, Amy, additional, Pfennig, Andrea, additional, Porichi, Evgenia, additional, Potash, James B., additional, Quested, Digby, additional, Raj, Towfique, additional, Rapaport, Mark H., additional, DePaulo, J. Raymond, additional, Regeer, Eline J., additional, Rice, John P., additional, Rivas, Fabio, additional, Rivera, Margarita, additional, Roth, Julian, additional, Roussos, Panos, additional, Ruderfer, Douglas M., additional, Sánchez-Mora, Cristina, additional, Schulte, Eva C., additional, Senner, Fanny, additional, Sharp, Sally, additional, Shilling, Paul D., additional, Sigurdsson, Engilbert, additional, Sirignano, Lea, additional, Slaney, Claire, additional, Smeland, Olav B., additional, Smith, Daniel J., additional, Sobell, Janet L., additional, Søholm Hansen, Christine, additional, Artigas, Maria Soler, additional, Spijker, Anne T., additional, Stein, Dan J., additional, Strauss, John S., additional, Świątkowska, Beata, additional, Terao, Chikashi, additional, Thorgeirsson, Thorgeir E., additional, Toma, Claudio, additional, Tooney, Paul, additional, Tsermpini, Evangelia-Eirini, additional, Vawter, Marquis P., additional, Vedder, Helmut, additional, Walters, James T. R., additional, Witt, Stephanie H., additional, Xi, Simon, additional, Xu, Wei, additional, Yang, Jessica Mei Kay, additional, Young, Allan H., additional, Young, Hannah, additional, Zandi, Peter P., additional, Zhou, Hang, additional, Zillich, Lea, additional, Psychiatry, HUNT All-In, additional, Adolfsson, Rolf, additional, Agartz, Ingrid, additional, Alda, Martin, additional, Alfredsson, Lars, additional, Babadjanova, Gulja, additional, Backlund, Lena, additional, Baune, Bernhard T., additional, Bellivier, Frank, additional, Bengesser, Susanne, additional, Berrettini, Wade H., additional, Blackwood, Douglas H. R., additional, Boehnke, Michael, additional, Børglum, Anders D., additional, Breen, Gerome, additional, Carr, Vaughan J., additional, Catts, Stanley, additional, Corvin, Aiden, additional, Craddock, Nicholas, additional, Dannlowski, Udo, additional, Dikeos, Dimitris, additional, Esko, Tõnu, additional, Etain, Bruno, additional, Ferentinos, Panagiotis, additional, Frye, Mark, additional, Fullerton, Janice M., additional, Gawlik, Micha, additional, Gershon, Elliot S., additional, Goes, Fernando S., additional, Green, Melissa J., additional, Grigoroiu-Serbanescu, Maria, additional, Hauser, Joanna, additional, Henskens, Frans, additional, Hillert, Jan, additional, Hong, Kyung Sue, additional, Hougaard, David M., additional, Hultman, Christina M., additional, Hveem, Kristian, additional, Iwata, Nakao, additional, Jablensky, Assen V., additional, Jones, Ian, additional, Jones, Lisa A., additional, S. Kahn, René, additional, Kelsoe, John R., additional, Kirov, George, additional, Landén, Mikael, additional, Leboyer, Marion, additional, Lewis, Cathryn M., additional, Li, Qingqin S., additional, Lissowska, Jolanta, additional, Lochner, Christine, additional, Loughland, Carmel, additional, Martin, Nicholas G., additional, Mathews, Carol A., additional, Mayoral, Fermin, additional, McElroy, Susan L., additional, McIntosh, Andrew M., additional, McMahon, Francis J., additional, Melle, Ingrid, additional, Michie, Patricia, additional, Milani, Lili, additional, Mitchell, Philip B., additional, Morken, Gunnar, additional, Mors, Ole, additional, Mortensen, Preben Bo, additional, Mowry, Bryan, additional, Müller-Myhsok, Bertram, additional, Myers, Richard M., additional, Neale, Benjamin M., additional, Nievergelt, Caroline M., additional, Nordentoft, Merete, additional, Nöthen, Markus M., additional, O’Donovan, Michael C., additional, Oedegaard, Ketil J., additional, Olsson, Tomas, additional, Owen, Michael J., additional, Paciga, Sara A., additional, Pantelis, Chris, additional, Pato, Carlos, additional, Pato, Michele T., additional, Patrinos, George P., additional, Perlis, Roy H., additional, Posthuma, Danielle, additional, Ramos-Quiroga, Josep Antoni, additional, Reif, Andreas, additional, Reininghaus, Eva Z., additional, Ribasés, Marta, additional, Rietschel, Marcella, additional, Ripke, Stephan, additional, Rouleau, Guy A., additional, Saito, Takeo, additional, Schall, Ulrich, additional, Schalling, Martin, additional, Schofield, Peter R., additional, Schulze, Thomas G., additional, Scott, Laura J., additional, Scott, Rodney J., additional, Serretti, Alessandro, additional, Weickert, Cynthia Shannon, additional, Smoller, Jordan W., additional, Stefansson, Hreinn, additional, Stefansson, Kari, additional, Stordal, Eystein, additional, Streit, Fabian, additional, Sullivan, Patrick F., additional, Turecki, Gustavo, additional, Vaaler, Arne E., additional, Vieta, Eduard, additional, Vincent, John B., additional, Waldman, Irwin D., additional, Weickert, Thomas W., additional, Werge, Thomas, additional, Wray, Naomi R., additional, Zwart, John-Anker, additional, Biernacka, Joanna M., additional, Nurnberger, John I., additional, Cichon, Sven, additional, Edenberg, Howard J., additional, Stahl, Eli A., additional, McQuillin, Andrew, additional, Di Florio, Arianna, additional, Ophoff, Roel A., additional, and Andreassen, Ole A., additional
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- 2020
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205. A genome-wide association study of asthma-COPD overlap syndrome (ACOS)
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John, Catherine, primary, Guyatt, Anna L, additional, Shrine, Nick, additional, Olafsdottir, Thorunn, additional, Liu, Jiangyuan, additional, Hayden, Lystra, additional, Chu, Su H, additional, Koskela, Jukka, additional, Luan, Jian'An, additional, Li, Xingnan, additional, Terzikhan, Natalie, additional, Xu, Hanfei, additional, Bartz, Traci M, additional, Petersen, Hans, additional, Leng, Shuguang, additional, Thorleifsson, Gudmar, additional, Meyers, Deborah A, additional, Bleecker, Eugene R, additional, Sakoda, Lori C, additional, Iribarren, Carlos, additional, Tesfaigzi, Yohannes, additional, Gharib, Sina A, additional, Dupuis, Josee, additional, Lahousse, Lies, additional, Ortega, Victor E, additional, Stefansson, Kari, additional, Sayers, Ian, additional, Hall, Ian P, additional, Langenberg, Claudia, additional, Ripatti, Samuli, additional, Laitinen, Tarja, additional, Wu, Ann C, additional, Lasky-Su, Jessica, additional, Hayward, Caroline, additional, Brumpton, Ben, additional, Langhammer, Arnulf, additional, Jonsdottir, Ingileif, additional, Cho, Michael H, additional, Wain, Louise V, additional, and Tobin, Martin D, additional
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- 2020
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206. Respiratory symptoms as risk factors for mortality – the Nordic EpiLung Study
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Backman, Helena, primary, Bhatta, Laxmi, additional, Hedman, Linnea, additional, Brumpton, Ben, additional, Vähätalo, Iida, additional, Lassman-Klee, Paul G, additional, Nwaru, Bright, additional, Mai, Xiao-Mei, additional, Vikjord, Sigrid Anna, additional, Lindberg, Anne, additional, Lundbäck, Bo, additional, Rönmark, Eva, additional, and Langhammer, Arnulf, additional
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- 2020
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207. Trans-ethnic Mendelian randomization study reveals causal relationships between cardio-metabolic factors and chronic kidney disease
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Zheng, Jie, primary, Zhang, YueMiao, additional, Rasheed, Humaira, additional, Walker, Venexia, additional, Sugawara, Yuka, additional, Li, JiaChen, additional, Leng, Yue, additional, Elsworth, Benjamin, additional, Wootton, Robyn E., additional, Fang, Si, additional, Yang, Qian, additional, Burgess, Stephen, additional, Haycock, Philip C., additional, Borges, Maria Carolina, additional, Cho, Yoonsu, additional, Carnegie, Rebecca, additional, Howell, Amy, additional, Robinson, Jamie, additional, Thomas, Laurent F, additional, Brumpton, Ben Michael, additional, Hveem, Kristian, additional, Hallan, Stein, additional, Franceschini, Nora, additional, Morris, Andrew P., additional, Köttgen, Anna, additional, Pattaro, Cristian, additional, Wuttke, Matthias, additional, Yamamoto, Masayuki, additional, Kashihara, Naoki, additional, Akiyama, Masato, additional, Kanai, Masahiro, additional, Matsuda, Koichi, additional, Kamatani, Yoichiro, additional, Okada, Yukinori, additional, Xu, Min, additional, Bi, YuFang, additional, Ning, Guang, additional, Smith, George Davey, additional, Barbour, Sean, additional, Yu, CanQing, additional, Åsvold, Bjørn Olav, additional, Zhang, Hong, additional, and Gaunt, Tom R., additional
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- 2020
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208. Lung function and exercise capacity in COPD phenotypes with and without emphysema
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Rasch-Halvorsen, Øystein, primary, Hassel, Erlend, additional, Brumpton, Ben, additional, Jenssen, Haldor, additional, Spruit, Martijn, additional, Langhammer, Arnulf, additional, and Steinshamn, Sigurd, additional
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- 2020
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209. Using human genetics to understand the causes and consequences of circulating cardiac troponin I in the general population
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Moksnes, Marta R, primary, Røsjø, Helge, additional, Richmond, Anne, additional, Lyngbakken, Magnus N, additional, Graham, Sarah E, additional, Hansen, Ailin Falkmo, additional, Wolford, Brooke N, additional, Taliun, Sarah A Gagliano, additional, LeFaive, Jonathon, additional, Rasheed, Humaira, additional, Thomas, Laurent F, additional, Zhou, Wei, additional, Surakka, Ida, additional, Douville, Nicholas J, additional, Campbell, Archie, additional, Porteous, David J, additional, Welsh, Paul, additional, Sattar, Naveed, additional, Smith, George Davey, additional, Fritsche, Lars G, additional, Nielsen, Jonas B, additional, Åsvold, Bjørn Olav, additional, Hveem, Kristian, additional, Hayward, Caroline, additional, Willer, Cristen J, additional, Brumpton, Ben M, additional, and Omland, Torbjørn, additional
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- 2020
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210. Genome-wide association study of skin and soft tissue infection susceptibility
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Rogne, Tormod, primary, Liyanarachi, Kristin V, additional, Rasheed, Humaira, additional, Thomas, Laurent F, additional, Flatby, Helene M, additional, Løset, Mari, additional, Gill, Dipender, additional, Burgess, Stephen, additional, Willer, Cristen J, additional, Hveem, Kristian, additional, Åsvold, Bjørn O, additional, Brumpton, Ben M, additional, DeWan, Andrew T, additional, Solligård, Erik, additional, and Damås, Jan K, additional
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- 2020
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211. Cardiometabolic traits, sepsis and severe covid-19: a Mendelian randomization investigation
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Ponsford, Mark J, primary, Gkatzionis, Apostolos, additional, Walker, Venexia M, additional, Grant, Andrew J, additional, Wootton, Robyn E, additional, Moore, Luke S P, additional, Fatumo, Segun, additional, Mason, Amy M, additional, Zuber, Verena, additional, Willer, Cristen, additional, Rasheed, Humaira, additional, Brumpton, Ben, additional, Hveem, Kristian, additional, Damås, Jan Kristian, additional, Davies, Neil, additional, Åsvold, Bjørn Olav, additional, Solligård, Erik, additional, Jones, Simon, additional, Burgess, Stephen, additional, Rogne, Tormod, additional, and Gill, Dipender, additional
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- 2020
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212. Variants associated with HHIP expression have sex-differential effects on lung function
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Fawcett, Katherine A., primary, Obeidat, Ma'en, additional, Melbourne, Carl, additional, Shrine, Nick, additional, Guyatt, Anna L., additional, John, Catherine, additional, Luan, Jian'an, additional, Richmond, Anne, additional, Moksnes, Marta R., additional, Granell, Raquel, additional, Weiss, Stefan, additional, Imboden, Medea, additional, May-Wilson, Sebastian, additional, Hysi, Pirro, additional, Boutin, Thibaud S., additional, Portas, Laura, additional, Flexeder, Claudia, additional, Harris, Sarah E., additional, Wang, Carol A., additional, Lyytikäinen, Leo-Pekka, additional, Palviainen, Teemu, additional, Foong, Rachel E., additional, Keidel, Dirk, additional, Minelli, Cosetta, additional, Langenberg, Claudia, additional, Bossé, Yohan, additional, Van den Berge, Maarten, additional, Sin, Don D., additional, Hao, Ke, additional, Campbell, Archie, additional, Porteous, David, additional, Padmanabhan, Sandosh, additional, Smith, Blair H., additional, Evans, David M., additional, Ring, Sue, additional, Langhammer, Arnulf, additional, Hveem, Kristian, additional, Willer, Cristen, additional, Ewert, Ralf, additional, Stubbe, Beate, additional, Pirastu, Nicola, additional, Klaric, Lucija, additional, Joshi, Peter K., additional, Patasova, Karina, additional, Massimo, Mangino, additional, Polasek, Ozren, additional, Starr, John M., additional, Karrasch, Stefan, additional, Strauch, Konstantin, additional, Meitinger, Thomas, additional, Rudan, Igor, additional, Rantanen, Taina, additional, Pietiläinen, Kirsi, additional, Kähönen, Mika, additional, Raitakari, Olli T., additional, Hall, Graham L., additional, Sly, Peter D., additional, Pennell, Craig E., additional, Kaprio, Jaakko, additional, Lehtimäki, Terho, additional, Vitart, Veronique, additional, Deary, Ian J., additional, Jarvis, Debbie, additional, Wilson, James F., additional, Spector, Tim, additional, Probst-Hensch, Nicole, additional, Wareham, Nicholas J., additional, Völzke, Henry, additional, Henderson, John, additional, Strachan, David P., additional, Brumpton, Ben M., additional, Hayward, Caroline, additional, Hall, Ian P., additional, Tobin, Martin D., additional, and Wain, Louise V., additional
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- 2020
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213. Is disrupted sleep a risk factor for Alzheimer’s disease? Evidence from a two-sample Mendelian randomization analysis
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Anderson, Emma L, primary, Richmond, Rebecca C, additional, Jones, Samuel E, additional, Hemani, Gibran, additional, Wade, Kaitlin H, additional, Dashti, Hassan S, additional, Lane, Jacqueline M, additional, Wang, Heming, additional, Saxena, Richa, additional, Brumpton, Ben, additional, Korologou-Linden, Roxanna, additional, Nielsen, Jonas B, additional, Åsvold, Bjørn Olav, additional, Abecasis, Gonçalo, additional, Coulthard, Elizabeth, additional, Kyle, Simon D, additional, Beaumont, Robin N, additional, Tyrrell, Jessica, additional, Frayling, Timothy M, additional, Munafò, Marcus R, additional, Wood, Andrew R, additional, Ben-Shlomo, Yoav, additional, Howe, Laura D, additional, Lawlor, Deborah A, additional, Weedon, Michael N, additional, and Davey Smith, George, additional
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- 2020
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214. Do maternal intrauterine environmental influences that lower offspring birthweight causally increase offspring cardiometabolic risk factors in later life? A Mendelian randomization study of 45,849 genotyped parent offspring pairs in the HUNT study
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Moen, Gunn-Helen, primary, Brumpton, Ben, additional, Willer, Cristen, additional, Åsvold, Bjørn Olav, additional, Birkeland, Kåre, additional, Neale, Michael C, additional, Freathy, Rachel M, additional, Smith, George Davey, additional, Lawlor, Deborah A, additional, Kirkpatrick, Robert M, additional, Warrington, Nicole M, additional, and Evans, David M, additional
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- 2020
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215. The association between normal lung function and peak oxygen uptake in patients with exercise intolerance and coronary artery disease
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Rasch-Halvorsen, Øystein, primary, Hassel, Erlend, additional, Brumpton, Ben M., additional, Jenssen, Haldor, additional, Spruit, Martijn A., additional, Langhammer, Arnulf, additional, and Steinshamn, Sigurd, additional
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- 2020
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216. Mitochondrial genome-wide association study of migraine – the HUNT Study
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Børte, Sigrid, primary, Zwart, John-Anker, additional, Skogholt, Anne Heidi, additional, Gabrielsen, Maiken Elvestad, additional, Thomas, Laurent F, additional, Fritsche, Lars G, additional, Surakka, Ida, additional, Nielsen, Jonas B, additional, Zhou, Wei, additional, Wolford, Brooke N, additional, Vigeland, Magnus D, additional, Hagen, Knut, additional, Kristoffersen, Espen Saxhaug, additional, Nyholt, Dale R, additional, Chasman, Daniel I, additional, Brumpton, Ben M, additional, Willer, Cristen J, additional, and Winsvold, Bendik S, additional
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- 2020
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217. Joint Effect of Multiple Prothrombotic Genotypes and Obesity on the Risk of Incident Venous Thromboembolism.
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Frischmuth, Tobias, Hindberg, Kristian, Gabrielsen, Maiken E., Brumpton, Ben, Hveem, Kristian, Brækkan, Sigrid K., Hansen, John-Bjarne, and Morelli, Vânia M.
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- 2022
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218. Investigating obesity‐related risk factors for childhood asthma.
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Chen, Yang‐Ching, Su, Ming‐Wei, Brumpton, Ben M., Lee, Yungling L., and Kalayci, Ömer
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ASTHMA in children ,WHEEZE ,CARDIOPULMONARY fitness ,PHYSICAL fitness ,CHILDREN'S health ,SURVIVAL analysis (Biometry) - Abstract
Background: We tested the hypothesis that multiple obesity‐related risk factors (obesity, physical activity, cardiopulmonary physical fitness, sleep‐disorder breathing (SDB), and sleep quality) are associated with childhood asthma using a Mendelian randomization (MR) design. Furthermore, we aim to investigate whether these risk factors were associated with incident asthma prospectively. Methods: In total, 7069 children aged 12 from the Taiwan Children Health Study were enrolled in the current study. Cross‐sectional logistic regression, one‐sample MR, summary‐level MR sensitivity analyses, and prospective survival analyses were used to investigate each causal pathway. Results: In MR analysis, three of the five risk factors (obesity, SDB, and sleep quality) were associated with asthma, with the highest effect sizes per inter‐quartile range (IQR) increase observed for sleep quality (odds ratio [OR] = 1.42; 95% confidence interval [CI]: 1.06 to 1.92) and the lowest for obesity (OR = 1.08; 95% CI: 1.00–1.16). In the prospective survival analysis, obesity showed the highest risk of incident asthma per IQR increase (hazard ratio [HR] = 1.28; 95% CI: 1.05 to 1.56), followed by SDB (HR = 1.18; 95% CI: 1.08 to 1.29) and sleep quality (HR = 1.10; 95% CI: 1.03 to 1.17). Conclusion: Among the examined factors, the most plausible risk factors for asthma were obesity, SDB, and poor sleep quality. For the prevention of childhood asthma, relevant stakeholders should prioritize improving children's sleep quality and preventing obesity comorbidities such as SDB. [ABSTRACT FROM AUTHOR]
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- 2022
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219. Multi‐phenotype analyses of hemostatic traits with cardiovascular events reveal novel genetic associations
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Temprano‐Sagrera, Gerard, Sitlani, Colleen M., Bone, William P., Martin‐Bornez, Miguel, Voight, Benjamin F., Morrison, Alanna C., Damrauer, Scott M., de Vries, Paul S., Smith, Nicholas L., Sabater‐Lleal, Maria, Dehghan, Abbas, Heath, Adam S, Morrison, Alanna C, Reiner, Alex P, Johnson, Andrew, Richmond, Anne, Peters, Annette, van Hylckama Vlieg, Astrid, McKnight, Barbara, Psaty, Bruce M, Hayward, Caroline, Ward‐Caviness, Cavin, O’Donnell, Christopher, Chasman, Daniel, Strachan, David P, Tregouet, David A, Mook‐Kanamori, Dennis, Gill, Dipender, Thibord, Florian, Asselbergs, Folkert W, Leebeek, Frank W.G., Rosendaal, Frits R, Davies, Gail, Homuth, Georg, Temprano, Gerard, Campbell, Harry, Taylor, Herman A, Bressler, Jan, Huffman, Jennifer E, Rotter, Jerome I, Yao, Jie, Wilson, James F, Bis, Joshua C, Hahn, Julie M, Desch, Karl C, Wiggins, Kerri L, Raffield, Laura M, Bielak, Lawrence F, Yanek, Lisa R, Kleber, Marcus E, Sabater‐Lleal, Maria, Mueller, Martina, Kavousi, Maryam, Mangino, Massimo, Liu, Melissa, Brown, Michael R, Conomos, Matthew P, Jhun, Min‐A, Chen, Ming‐Huei, de Maat, Moniek P.M., Pankratz, Nathan, Smith, Nicholas L, Peyser, Patricia A, Elliot, Paul, de Vries, Paul S, Wei, Peng, Wild, Philipp S, Morange, Pierre E, van der Harst, Pim, Yang, Qiong, Le, Ngoc‐Quynh, Marioni, Riccardo, Li, Ruifang, Damrauer, Scott M, Cox, Simon R, Trompet, Stella, Felix, Stephan B, Völker, Uwe, Tang, Weihong, Koenig, Wolfgang, Jukema, J. Wouter, Guo, Xiuqing, Lindstrom, Sara, Wang, Lu, Smith, Erin N, Gordon, William, van Hylckama Vlieg, Astrid, de Andrade, Mariza, Brody, Jennifer A, Pattee, Jack W, Haessler, Jeffrey, Brumpton, Ben M, Chasman, Daniel I, Suchon, Pierre, Chen, Ming‐Huei, Turman, Constance, Germain, Marine, Wiggins, Kerri L, MacDonald, James, Braekkan, Sigrid K, Armasu, Sebastian M, Pankratz, Nathan, Jackson, Rabecca D, Nielsen, Jonas B, Giulianini, Franco, Puurunen, Marja K, Ibrahim, Manal, Heckbert, Susan R, Bammler, Theo K, Frazer, Kelly A, McCauley, Bryan M, Taylor, Kent, Pankow, James S, Reiner, Alexander P, Gabrielsen, Maiken E, Deleuze, Jean‐François, O’Donnell, Chris J, Kim, Jihye, McKnight, Barbara, Kraft, Peter, Hansen, John‐Bjarne, Rosendaal, Frits R, Heit, John A, Psaty, Bruce M, Tang, Weihong, Kooperberg, Charles, Hveem, Kristian, Ridker, Paul M, Morange, Pierre‐Emmanuel, Johnson, Andrew D, Kabrhel, Christopher, Trégouët, David‐Alexandre, Smith, Nicholas L, Malik, Rainer, Chauhan, Ganesh, Traylor, Matthew, Sargurupremraj, Muralidharan, Okada, Yukinori, Mishra, Aniket, Rutten‐Jacobs, Loes, Giese, Anne‐Katrin, van der Laan, Sander W, Gretarsdottir, Solveig, Anderson, Christopher D, Chong, Michael, Adams, Hieab HH, Ago, Tetsuro, Almgren, Peter, Amouyel, Philippe, Ay, Hakan, Bartz, Traci M, Benavente, Oscar R, Bevan, Steve, Boncoraglio, Giorgio B, Brown, Robert D, Butterworth, Adam S, Carrera, Caty, Carty, Cara L, Chasman, Daniel I, Chen, Wei‐Min, Cole, John W, Correa, Adolfo, Cotlarciuc, Ioana, Cruchaga, Carlos, Danesh, John, de Bakker, Paul IW, DeStefano, Anita L, den Hoed, Marcel, Duan, Qing, Engelter, Stefan T, Falcone, Guido J, Gottesman, Rebecca F, Grewal, Raji P, Gudnason, Vilmundur, Gustafsson, Stefan, Haessler, Jeffrey, Harris, Tamara B, Hassan, Ahamad, Havulinna, Aki S, Heckbert, Susan R, Holliday, Elizabeth G, Howard, George, Hsu, Fang‐Chi, Hyacinth, Hyacinth I, Arfan Ikram, M, Ingelsson, Erik, Irvin, Marguerite R, Jian, Xueqiu, Jiménez‐Conde, Jordi, Johnson, Julie A, Jukema, J Wouter, Kanai, Masahiro, Keene, Keith L, Kissela, Brett M, Kleindorfer, Dawn O, Kooperberg, Charles, Kubo, Michiaki, Lange, Leslie A, Langefeld, Carl D, Langenberg, Claudia, Launer, Lenore J, Lee, Jin‐Moo, Lemmens, Robin, Leys, Didier, Lewis, Cathryn M, Lin, Wei‐Yu, Lindgren, Arne G, Lorentzen, Erik, Magnusson, Patrik K, Maguire, Jane, Manichaikul, Ani, McArdle, Patrick F, Meschia, James F, Mitchell, Braxton D, Mosley, Thomas H, Nalls, Michael A, Ninomiya, Toshiharu, O’Donnell, Martin J, Psaty, Bruce M, Pulit, Sara L, Rannikmäe, Kristiina, Reiner, Alexander P, Rexrode, Kathryn M, Rice, Kenneth, Rich, Stephen S, Ridker, Paul M, Rost, Natalia S, Rothwell, Peter M, Rotter, Jerome I, Rundek, Tatjana, Sacco, Ralph L, Sakaue, Saori, Sale, Michele M, Salomaa, Veikko, Sapkota, Bishwa R, Schmidt, Reinhold, Schmidt, Carsten O, Schminke, Ulf, Sharma, Pankaj, Slowik, Agnieszka, Sudlow, Cathie LM, Tanislav, Christian, Tatlisumak, Turgut, Taylor, Kent D, Thijs, Vincent NS, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Tiedt, Steffen, Trompet, Stella, Tzourio, Christophe, van Duijn, Cornelia M, Walters, Matthew, Wareham, Nicholas J, Wassertheil‐Smoller, Sylvia, Wilson, James G, Wiggins, Kerri L, Yang, Qiong, Yusuf, Salim, Amin, Najaf, Aparicio, Hugo S, Arnett, Donna K, Attia, John, Beiser, Alexa S, Berr, Claudine, Buring, Julie E, Bustamante, Mariana, Caso, Valeria, Cheng, Yu‐Ching, Hoan Choi, Seung, Chowhan, Ayesha, Cullell, Natalia, Dartigues, Jean‐François, Delavaran, Hossein, Delgado, Pilar, Dörr, Marcus, Engström, Gunnar, Ford, Ian, Gurpreet, Wander S, Hamsten, Anders, Heitsch, Laura, Hozawa, Atsushi, Ibanez, Laura, Ilinca, Andreea, Ingelsson, Martin, Iwasaki, Motoki, Jackson, Rebecca D, Jood, Katarina, Jousilahti, Pekka, Kaffashian, Sara, Kalra, Lalit, Kamouchi, Masahiro, Kitazono, Takanari, Kjartansson, Olafur, Kloss, Manja, Koudstaal, Peter J, Krupinski, Jerzy, Labovitz, Daniel L, Laurie, Cathy C, Levi, Christopher R, Li, Linxin, Lind, Lars, Lindgren, Cecilia M, Lioutas, Vasileios, Mei Liu, Yong, Lopez, Oscar L, Makoto, Hirata, Martinez‐Majander, Nicolas, Matsuda, Koichi, Minegishi, Naoko, Montaner, Joan, Morris, Andrew P, Muiño, Elena, Müller‐Nurasyid, Martina, Norrving, Bo, Ogishima, Soichi, Parati, Eugenio A, Reddy Peddareddygari, Leema, Pedersen, Nancy L, Pera, Joanna, Perola, Markus, Pezzini, Alessandro, Pileggi, Silvana, Rabionet, Raquel, Riba‐Llena, Iolanda, Ribasés, Marta, Romero, Jose R, Roquer, Jaume, Rudd, Anthony G, Sarin, Antti‐Pekka, Sarju, Ralhan, Sarnowski, Chloe, Sasaki, Makoto, Satizabal, Claudia L, Satoh, Mamoru, Sattar, Naveed, Sawada, Norie, Sibolt, Gerli, Sigurdsson, Ásgeir, Smith, Albert, Sobue, Kenji, Soriano‐Tárraga, Carolina, Stanne, Tara, Colin Stine, O, Stott, David J, Strauch, Konstantin, Takai, Takako, Tanaka, Hideo, Tanno, Kozo, Teumer, Alexander, Tomppo, Liisa, Torres‐Aguila, Nuria P, Touze, Emmanuel, Tsugane, Shoichiro, Uitterlinden, Andre G, Valdimarsson, Einar M, van der Lee, Sven J, Völzke, Henry, Wakai, Kenji, Weir, David, Williams, Stephen R, Wolfe, Charles DA, Wong, Quenna, Xu, Huichun, Yamaji, Taiki, Sanghera, Dharambir K, Melander, Olle, Jern, Christina, Strbian, Daniel, Fernandez‐Cadenas, Israel, Longstreth, W T, Rolfs, Arndt, Hata, Jun, Woo, Daniel, Rosand, Jonathan, Pare, Guillaume, Hopewell, Jemma C, Saleheen, Danish, Stefansson, Kari, Worrall, Bradford B, Kittner, Steven J, Seshadri, Sudha, Fornage, Myriam, Markus, Hugh S, Howson, Joanna MM, Kamatani, Yoichiro, Debette, Stephanie, and Dichgans, Martin
- Abstract
Multi‐phenotype analysis of genetically correlated phenotypes can increase the statistical power to detect loci associated with multiple traits, leading to the discovery of novel loci. This is the first study to date to comprehensively analyze the shared genetic effects within different hemostatic traits, and between these and their associated disease outcomes.
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- 2022
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220. Investigating causal relationships between sleep traits and risk of breast cancer:a Mendelian randomization study
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Richmond, Rebecca, Anderson, Emma, Dashti, Hassan S, Jones, Samuel E, Lane, Jacqueline M., Strand, Linn Beate, Brumpton, Ben, Rutter, Martin K, Wood, Andrew R, Straif, Kurt, Relton, Caroline, Munafo, Marcus, Frayling, Timothy M, Martin, Richard, Saxena, Richa, Weedon, Michael N, Lawlor, Debbie, and Davey Smith, George
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Physical and Mental Health ,ICEP ,Brain and Behaviour - Abstract
ObjectiveTo examine whether sleep traits have a causal effect on risk of breast cancer. DesignMultivariable regression, one- and two-sample Mendelian randomization. SettingThe UK Biobank prospective cohort study and the Breast Cancer Association Consortium (BCAC) case-control genome-wide association study. Participants156,848 women in the multivariable regression and one-sample Mendelian randomization analysis in UK Biobank (7,784 with a breast cancer diagnosis) and 122,977 breast cancer cases and 105,974 controls from BCAC in the two-sample Mendelian randomization analysis. ExposuresSelf-reported chronotype (morning/evening preference), insomnia symptoms and sleep duration in multivariable regression, and genetic variants robustly associated with these sleep traits. Main outcome measuresBreast cancer diagnosis. ResultsIn multivariable regression analysis using UK Biobank data on breast cancer incidence, morning preference was inversely associated with breast cancer (HR 0.95, 95% CI 0.93 to 0.98 per category increase) while there was little evidence for an association with sleep duration and insomnia symptoms. Using 341 single nucleotide polymorphisms (SNPs) associated with chronotype, 91 SNPs associated sleep duration and 57 SNPs associated with insomnia symptoms, one-sample MR analysis in UK Biobank provided some supportive evidence for a protective effect of morning preference on breast cancer risk (HR 0.85, 95% 0.70, 1.03 per category increase) but imprecise estimates for sleep duration and insomnia symptoms. Two-sample MR using data from BCAC supported findings for a protective effect of morning preference (OR 0.88, 95% CI 0.82 to 0.93 per category increase) and adverse effect of increased sleep duration (OR 1.19, 95% CI 1.02 to 1.39 per hour increase) on breast cancer (both estrogen receptor positive and negative), while there was inconsistent evidence for insomnia symptoms. Results were largely robust to sensitivity analyses accounting for horizontal pleiotropy.ConclusionsWe found consistent evidence for a protective effect of morning preference and suggestive evidence for an adverse effect of increased sleep duration on breast cancer risk.
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- 2019
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221. Variation in Serum PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9), Cardiovascular Disease Risk, and an Investigation of Potential Unanticipated Effects of PCSK9 Inhibition
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Brumpton, Ben, Fritsche, Lars G, Zheng, Jie, Davey Smith, George, and Åsvold, Bjørn Olav
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PCSK9 inhibitors have strong effects on lowering low-density lipoprotein cholesterol (LDL-C) and subsequent risk of cardiovascular disease. While a number of trials have evaluated the safety of such inhibitors in long-term clinical trials, a broad investigation of potential outcomes over the life-time, leveraging genetic variation in PCSK9 levels, has not been conducted. We aimed to investigate genetic variants associated with serum PCSK9 and the effect of LDL-C lowering variants on a range of potential outcomes.To achive this, we used data from the Nord-Trøndelag Health Study (HUNT)(n=69,424), a large population-based health study of the inhabitants of Nord-Trøndelag county, Norway. Firstly, we preformed a genome-wide association study of serum PCSK9 measured in 3697adults. Secondly we created a genetic risk score for PCSK9 as well as utilized existing scores for PCSK9 and HMGCR, and regressed these on a borad range of outcomes in the total sample. Thirdly, we perfomed two-sample medelian randomization on 50 outcomes using publically available datasets. Finally, we assessed the genetic correlation between PCSK9 and 229 diseases or traits using LD score regression.Three independent variants were GWAS significant (rs11591147, rs499883 and rs192265866). Using both existing genetic risk scores and scores defined from this discovery GWAS; we confirmed a strong association between serum PCSK9 and lower LDL-C and reducing risk of cardiovascular disease. We did not observe any consistently strong potentially adverse or beneficial associations. We observed some strong but not statistically significant genetic correlations between serum PCSK9 and fasting insulin, urate, uric acid and caudate volume.The lack of association between the genetic risk scores for PCSK9 and HMGCR is reassuring for the use of these treatments. However, further studies are warranted to confirm our findings, follow-up on the functional influences of the variants identified and extend our investigations to other outcomes.
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- 2019
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222. The Association of Bone Mineral Density with Mortality in a COPD Cohort. The HUNT Study, Norway
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Vikjord, Sigrid Anna Aalberg, Brumpton, Ben Michael, Mai, Xiao-Mei, Bhatta, Laxmi, Vanfleteren, Lowie, and Langhammer, Arnulf
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respiratory tract diseases - Abstract
In individuals with chronic obstructive pulmonary disease (COPD), the presence of comorbidities is associated with increased mortality risk. We wanted to study the association between bone mineral density (BMD) and mortality among individuals with COPD in a population-based cohort study. Participants were recruited from the second (1995–1997) and third (2006–2008) surveys of the HUNT Study and followed until February 2019. Hip and forearm BMD were included as continuous T-scores or categorized according to WHO criteria (normal, osteopenia, and osteoporosis). Hazard ratios with 95% confidence intervals were estimated by multivariable Cox regression models. In total, 2076 and 3239 participants were identified as having COPD by FEV1/FVC below lower limit of normal (LLN) or T-scores were associated with a 5% (95% confidence interval (CI) 1.01–1.09) increased mortality in the GLI-COPD and GOLD-COPD cohorts, respectively. However, the presence of osteoporosis (T < –2.5), compared to normal BMD, was not associated with mortality in neither GLI-COPD (HR 1.13, 95% CI 0.91–1.41) nor GOLD-COPD cohorts (HR 1.22, 95% CI 0.99–1.51). Thus, a small positive association was found between decreasing BMD T-score and mortality in both GLI-COPD and GOLD-COPD. However, osteoporosis as defined by WHO was not associated with mortality, probably due to loss of power upon categorization.
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- 2019
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223. Prolonged Sitting, Its Combination With Physical Inactivity and Incidence of Lung Cancer: Prospective Data From the HUNT Study
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Jiang, Lin, Sun, Yi-Qian, Brumpton, Ben Michael, Langhammer, Arnulf, Chen, Yue, Nilsen, Tom Ivar Lund, and Mai, Xiao-Mei
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Background: Prolonged sitting as a major sedentary behavior potentially contributes to illness, but its relation with lung cancer risk is unclear. Prolonged sitting can be presented in physically active or inactive individuals. Those who are extendedly seated and also physically inactive may represent the most sedentary people. We therefore aimed to prospectively examine if total sitting time daily itself or in combination with physical activity is associated with lung cancer incidence overall and histologic types. Methods: We included 45,810 cancer-free adults who participated in the second survey of HUNT Study in Norway (1995–97), with a median follow-up of 18.3 years. Total sitting time daily and physical activity were self-reported at baseline. Lung cancer cases were ascertained from the Cancer Registry of Norway. Cox regression was used to estimate hazard ratios (HRs) with 95% confidence intervals (CIs). Results: In total, 549 participants developed lung cancer during the follow-up. Total sitting time daily was not associated with the incidence of lung cancer overall and histologic subtypes. Compared with participants sitting < 8 h daily and being physically active, those sitting ≥8 h daily (prolonged sitting) and being physically inactive had an increased incidence of lung cancer (overall: adjusted HR = 1.44, 95% CI: 1.07–1.94; small cell lung cancer: adjusted HR = 2.58, 95% CI: 1.23–5.41). Prolonged sitting only or physical inactivity only was not associated with the incidence of lung cancer. Conclusions: Our study suggested that prolonged sitting was not independently associated with lung cancer incidence. The combination of prolonged sitting and physical inactivity might increase the risk of lung cancer. However, residual confounding by smoking cannot be excluded completely even though smoking was adjusted for with detailed information. Copyright © 2019 Jiang, Sun, Brumpton, Langhammer, Chen, Nilsen and Mai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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- 2019
224. Differences of FENO in adult general populations of Nordic regions
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Lassmann-Klee, Paul, Brumpton, Ben, Henriksen, Anne Hildur, Larsson, Matz, Sundblad, Britt-Marie, Pölluste, Jaak, Lindqvist, Ari, Hedman, Linnea, Backman, Helena, Rönmark, Eva, Langhammer, Arnulf, Piirilä, Päivi, Sovijärvi, Anssi R. A., Lassmann-Klee, Paul, Brumpton, Ben, Henriksen, Anne Hildur, Larsson, Matz, Sundblad, Britt-Marie, Pölluste, Jaak, Lindqvist, Ari, Hedman, Linnea, Backman, Helena, Rönmark, Eva, Langhammer, Arnulf, Piirilä, Päivi, and Sovijärvi, Anssi R. A.
- Abstract
Supplement: 63. Meeting Abstract: PA5064.
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- 2019
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225. Is high vitamin B12 status a cause of lung cancer?
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Fanidi, Anouar, Carreras-Torres, Robert, Larose, Tricia L., Yuan, Jian-Min, Stevens, Victoria L., Weinstein, Stephanie J., Albanes, Demetrius, Prentice, Ross, Pettinger, Mary, Cai, Qiuyin, Blot, William J., Arslan, Alan A., Zeleniuch-Jacquotte, Anne, McCullough, Marjorie L., Le Marchand, Loic, Wilkens, Lynne R., Haiman, Christopher A., Zhang, Xuehong, Stampfer, Meir J., Smith-Warner, Stephanie A., Giovannucci, Edward, Giles, Graham G., Hodge, Allison M., Severi, Gianluca, Johansson, Mikael, Grankvist, Kjell, Langhammer, Arnulf, Brumpton, Ben M., Wang, Renwei, Gao, Yu-Tang, Ericson, Ulrika, Bojesen, Stig E., Arnold, Susanne M., Koh, Woon-Puay, Shu, Xiao-Ou, Xiang, Yong-Bing, Li, Honglan, Zheng, Wei, Lan, Qing, Visvanathan, Kala, Hoffman-Bolton, Judith, Ueland, Per M., Midttun, Oivind, Caporaso, Neil E., Purdue, Mark, Freedman, Neal D., Buring, Julie E., Lee, I-Min, Sesso, Howard D., Gaziano, J. Michael, Manjer, Jonas, Relton, Caroline L., Hung, Rayjean J., Amos, Chris, I, Johansson, Mattias, Brennan, Paul, Fanidi, Anouar, Carreras-Torres, Robert, Larose, Tricia L., Yuan, Jian-Min, Stevens, Victoria L., Weinstein, Stephanie J., Albanes, Demetrius, Prentice, Ross, Pettinger, Mary, Cai, Qiuyin, Blot, William J., Arslan, Alan A., Zeleniuch-Jacquotte, Anne, McCullough, Marjorie L., Le Marchand, Loic, Wilkens, Lynne R., Haiman, Christopher A., Zhang, Xuehong, Stampfer, Meir J., Smith-Warner, Stephanie A., Giovannucci, Edward, Giles, Graham G., Hodge, Allison M., Severi, Gianluca, Johansson, Mikael, Grankvist, Kjell, Langhammer, Arnulf, Brumpton, Ben M., Wang, Renwei, Gao, Yu-Tang, Ericson, Ulrika, Bojesen, Stig E., Arnold, Susanne M., Koh, Woon-Puay, Shu, Xiao-Ou, Xiang, Yong-Bing, Li, Honglan, Zheng, Wei, Lan, Qing, Visvanathan, Kala, Hoffman-Bolton, Judith, Ueland, Per M., Midttun, Oivind, Caporaso, Neil E., Purdue, Mark, Freedman, Neal D., Buring, Julie E., Lee, I-Min, Sesso, Howard D., Gaziano, J. Michael, Manjer, Jonas, Relton, Caroline L., Hung, Rayjean J., Amos, Chris, I, Johansson, Mattias, and Brennan, Paul
- Abstract
Vitamin B supplementation can have side effects for human health, including cancer risk. We aimed to elucidate the role of vitamin B12 in lung cancer etiology via direct measurements of pre‐diagnostic circulating vitamin B12 concentrations in a nested case–control study, complemented with a Mendelian randomization (MR) approach in an independent case–control sample. We used pre‐diagnostic biomarker data from 5183 case–control pairs nested within 20 prospective cohorts, and genetic data from 29,266 cases and 56,450 controls. Exposures included directly measured circulating vitamin B12 in pre‐diagnostic blood samples from the nested case–control study, and 8 single nucleotide polymorphisms associated with vitamin B12 concentrations in the MR study. Our main outcome of interest was increased risk for lung cancer, overall and by histological subtype, per increase in circulating vitamin B12 concentrations. We found circulating vitamin B12 to be positively associated with overall lung cancer risk in a dose response fashion (odds ratio for a doubling in B12 [ORlog2B12] = 1.15, 95% confidence interval (95%CI) = 1.06–1.25). The MR analysis based on 8 genetic variants also indicated that genetically determined higher vitamin B12 concentrations were positively associated with overall lung cancer risk (OR per 150 pmol/L standard deviation increase in B12 [ORSD] = 1.08, 95%CI = 1.00–1.16). Considering the consistency of these two independent and complementary analyses, these findings support the hypothesis that high vitamin B12 status increases the risk of lung cancer.
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- 2019
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226. Author Correction: Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors
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Bakker, Mark K, van der Spek, Rick A A, Terao, Chikashi, Bulters, Diederik, Kitchen, Neil, Brown, Martin, Grieve, Joan, Matsuda, Koichi, Walters, Robin G, Lin, Kuang, Li, Liming, Millwood, Iona Y, Chen, Zhengming, Rouleau, Guy A, Zhou, Sirui, Rannikmäe, Kristiina, van Rheenen, Wouter, Sudlow, Cathie L M, Houlden, Henry, van den Berg, Leonard H, Dina, Christian, Naggara, Olivier, Gentric, Jean-Christophe, Shotar, Eimad, Eugène, François, Desal, Hubert, Winsvold, Bendik S, Morel, Sandrine, Børte, Sigrid, Johnsen, Marianne Bakke, Brumpton, Ben M, Sandvei, Marie Søfteland, Willer, Cristen J, Hveem, Kristian, Zwart, John-Anker, Verschuren, W M Monique, Friedrich, Christoph M, Hirsch, Sven, Bourcier, Romain, Schilling, Sabine, Dauvillier, Jérôme, Martin, Olivier, Stroke, HUNT All-In, Group, China Kadoorie Biobank Collaborative, Consortium, BioBank Japan Project, Group, ICAN Study, Group, CADISP, Genetics, Haemorrhage, Observational Subarachnoid, Hostettler, Isabel C, Consortium, International Stroke Genetics, Jones, Gregory T, Bown, Matthew J, Ko, Nerissa U, Kim, Helen, Coleman, Jonathan R I, Breen, Gerome, Zaroff, Jonathan G, Klijn, Catharina J M, Malik, Rainer, Alg, Varinder S, Dichgans, Martin, Sargurupremraj, Muralidharan, Tatlisumak, Turgut, Amouyel, Philippe, Debette, Stéphanie, Rinkel, Gabriel J E, Worrall, Bradford B, Pera, Joanna, Slowik, Agnieszka, Gaál-Paavola, Emília I, van Eijk, Kristel R, Niemelä, Mika, Jääskeläinen, Juha E, von Und Zu Fraunberg, Mikael, Lindgren, Antti, Broderick, Joseph P, Werring, David J, Woo, Daniel, Redon, Richard, Bijlenga, Philippe, Kamatani, Yoichiro, Koido, Masaru, Veldink, Jan H, Ruigrok, Ynte M, Bian, Zheng, Chen, Junshi, Chen, Yiping, Clarke, Robert, Collins, Rory, Guo, Yu, Han, Xiao, Hill, Michael, Akiyama, Masato, Liu, Depei, Lv, Jun, Millwood, Iona, Peto, Richard, Sansome, Sam, Walters, Robin, Yang, Xiaoming, Yu, Canqing, Bonner, Stephen, and Walsh, Daniel
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572: Biochemie ,ddc:570 ,Medizin ,Genetics ,MEDLINE ,Genome-wide association study ,Computational biology ,Biology ,Clinical risk factor ,616: Innere Medizin und Krankheiten - Abstract
In the version of this article initially published, the following statement was missing from the Acknowledgements: “We are grateful to the GenoBiRD core facility (Biogenouest), the Clinical Investigation Center (INSERM CIC1413) and the Center of Biological Resources in Nantes (BB-0033-00040; CHU Nantes, France) for their assistance in managing and genotyping the ICAN and PREGO biobanks. R.R. was supported by the French Regional Council of Pays-de-la-Loire (VaCaRMe program) and the Agence Nationale de la Recherche (ANR-15-CE17-0008-01 to G.L). H.D. and R.B. were supported by the French Ministry of Health (clinical trial NCT02848495 to H.D.), the Genavie Foundation, the Société Française de Radiologie and the Société Française de Neuroradiologie.” The error has been corrected in the HTML and PDF versions of the article. *Lists of authors and their affiliations appear online. Korrektur zu 10.1038/s41588-020-00725-7
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- 2020
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227. Sex hormones and risk of lung and colorectal cancers in women: a Mendelian randomization study.
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Denos, Marion, Sun, Yi-Qian, Brumpton, Ben Michael, Li, Yafang, Albanes, Demetrius, Burnett-Hartman, Andrea, Campbell, Peter T., Küry, Sébastien, Li, Christopher I., White, Emily, Samadder, Jewel N., Jenkins, Mark A., and Mai, Xiao-Mei
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GENOME-wide association studies , *SEX hormones , *LUNG cancer , *COLORECTAL cancer , *CANCER patients - Abstract
The roles of sex hormones such as estradiol, testosterone, and sex hormone-binding globulin (SHBG) in the etiology of lung and colorectal cancers in women, among the most common cancers after breast cancer, are unclear. This Mendelian randomization (MR) study evaluated such potential causal associations in women of European ancestry. We used summary statistics data from genome-wide association studies on sex hormones and from the Trøndelag Health Study (HUNT) and large consortia on cancers. There was suggestive evidence of 1-standard deviation increase in total testosterone levels being associated with a lower risk of lung non-adenocarcinoma (hazard ratio 0.60, 95% confidence interval 0.37–0.98) in the HUNT Study. However, this was not confirmed by using data from a larger consortium. In general, we did not find convincing evidence to support a causal role of sex hormones on risk of lung and colorectal cancers in women of European ancestry. [ABSTRACT FROM AUTHOR]
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- 2024
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228. Is disrupted sleep a risk factor for Alzheimer's disease? Evidence from a two-sample Mendelian randomization analysis.
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Anderson, Emma L, Richmond, Rebecca C, Jones, Samuel E, Hemani, Gibran, Wade, Kaitlin H, Dashti, Hassan S, Lane, Jacqueline M, Wang, Heming, Saxena, Richa, Brumpton, Ben, Korologou-Linden, Roxanna, Nielsen, Jonas B, Åsvold, Bjørn Olav, Abecasis, Gonçalo, Coulthard, Elizabeth, Kyle, Simon D, Beaumont, Robin N, Tyrrell, Jessica, Frayling, Timothy M, and Munafò, Marcus R
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DROWSINESS ,ALZHEIMER'S disease ,GENOME-wide association studies ,SLEEP ,RESEARCH ,SEQUENCE analysis ,RESEARCH methodology ,MEDICAL cooperation ,EVALUATION research ,COMPARATIVE studies ,RESEARCH funding - Abstract
Background: It is established that Alzheimer's disease (AD) patients experience sleep disruption. However, it remains unknown whether disruption in the quantity, quality or timing of sleep is a risk factor for the onset of AD.Methods: We used the largest published genome-wide association studies of self-reported and accelerometer-measured sleep traits (chronotype, duration, fragmentation, insomnia, daytime napping and daytime sleepiness), and AD. Mendelian randomization (MR) was used to estimate the causal effect of self-reported and accelerometer-measured sleep parameters on AD risk.Results: Overall, there was little evidence to support a causal effect of sleep traits on AD risk. There was some suggestive evidence that self-reported daytime napping was associated with lower AD risk [odds ratio (OR): 0.70, 95% confidence interval (CI): 0.50-0.99). Some other sleep traits (accelerometer-measured 'eveningness' and sleep duration, and self-reported daytime sleepiness) had ORs of a similar magnitude to daytime napping, but were less precisely estimated.Conclusions: Overall, we found very limited evidence to support a causal effect of sleep traits on AD risk. Our findings provide tentative evidence that daytime napping may reduce AD risk. Given that this is the first MR study of multiple self-report and objective sleep traits on AD risk, findings should be replicated using independent samples when such data become available. [ABSTRACT FROM AUTHOR]- Published
- 2021
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229. The Association of Bone Mineral Density with Mortality in a COPD Cohort. The HUNT Study, Norway
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Vikjord, Sigrid Anna Aalberg, primary, Brumpton, Ben Michael, additional, Mai, Xiao-Mei, additional, Bhatta, Laxmi, additional, Vanfleteren, Lowie, additional, and Langhammer, Arnulf, additional
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- 2019
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230. Within family Mendelian randomization studies
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Davies, Neil M, primary, Howe, Laurence J, additional, Brumpton, Ben, additional, Havdahl, Alexandra, additional, Evans, David M, additional, and Davey Smith, George, additional
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- 2019
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231. Adiposity and asthma in adults: a bidirectional Mendelian randomisation analysis of The HUNT Study
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Sun, Yi-Qian, primary, Brumpton, Ben Michael, additional, Langhammer, Arnulf, additional, Chen, Yue, additional, Kvaløy, Kirsti, additional, and Mai, Xiao-Mei, additional
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- 2019
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232. Differences of FENO in adult general populations of Nordic regions
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Lassmann-Klee, Paul, primary, Brumpton, Ben, additional, Henriksen, Anne Hildur, additional, Larsson, Matz, additional, Sundblad, Britt-Marie, additional, Põlluste, Jaak, additional, Lindqvist, Ari, additional, Hedman, Linnea, additional, Backman, Helena, additional, Rönmark, Eva, additional, Langhammer, Arnulf, additional, Piirilä, Päivi, additional, and Sovijärvi, Anssi R.A., additional
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- 2019
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233. Asthma is still a risk factor for mortality in Sweden and Norway – the Nordic EpiLung Study
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Backman, Helena, primary, Bhatta, Laxmi, additional, Hedman, Linnea, additional, Brumpton, Ben, additional, Vähätalo, Iida, additional, Lassman-Klee, Paul G., additional, Nwaru, Bright I., additional, Mai, Xiao-Mei, additional, Vikjord, Sigrid Anna, additional, Lindberg, Anne, additional, Lundbäck, Bo, additional, Rönmark, Eva, additional, and Langhammer, Arnulf, additional
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- 2019
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234. The association of anxiety and depression with mortality, symptom burden and health care utilization in a COPD cohort. The HUNT Study, Norway
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Vikjord, Sigrid Anna, primary, Mai, Xiao-Mei, additional, Brumpton, Ben, additional, and Langhammer, Arnulf, additional
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- 2019
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235. Asthma, asthma control and risk of stroke: the Nord-Trøndelag Health Study (HUNT)
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Cepelis, Aivaras, primary, Brumpton, Ben, additional, Laugsand, Lars, additional, Langhammer, Arnulf, additional, Janszky, Imre, additional, and Strand, Linn, additional
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- 2019
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236. Comparison of pre‐ and post‐bronchodilator lung function as predictors of mortality: The HUNT Study
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Bhatta, Laxmi, primary, Leivseth, Linda, additional, Carslake, David, additional, Langhammer, Arnulf, additional, Mai, Xiao‐Mei, additional, Chen, Yue, additional, Henriksen, Anne H., additional, and Brumpton, Ben M., additional
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- 2019
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237. Investigating causal relations between sleep traits and risk of breast cancer in women: mendelian randomisation study
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Richmond, Rebecca C, primary, Anderson, Emma L, additional, Dashti, Hassan S, additional, Jones, Samuel E, additional, Lane, Jacqueline M, additional, Strand, Linn Beate, additional, Brumpton, Ben, additional, Rutter, Martin K, additional, Wood, Andrew R, additional, Straif, Kurt, additional, Relton, Caroline L, additional, Munafò, Marcus, additional, Frayling, Timothy M, additional, Martin, Richard M, additional, Saxena, Richa, additional, Weedon, Michael N, additional, Lawlor, Debbie A, additional, and Smith, George Davey, additional
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- 2019
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238. Is disrupted sleep a risk factor for Alzheimer’s disease? Evidence from a two-sample Mendelian randomization analysis
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Anderson, Emma L, primary, Richmond, Rebecca C, additional, Jones, Samuel E, additional, Hemani, Gibran, additional, Wade, Kaitlin. H, additional, Dashti, Hassan S, additional, Lane, Jacqueline M, additional, Wang, Heming, additional, Saxena, Richa, additional, Brumpton, Ben, additional, Korologou-Linden, Roxanna, additional, Nielson, Jonas B, additional, Olav Åsvold, Bjørn, additional, Abecasis, Gonçalo, additional, Coulthard, Elizabeth, additional, Kyle, Simon D., additional, Beaumont, Robin N, additional, Tyrrell, Jessica, additional, Frayling, Timothy M, additional, Munafò, Marcus R, additional, Wood, Andrew R, additional, Ben-Shlomo, Yoav, additional, Howe, Laura D, additional, Lawlor, Debbie A, additional, Weedon, Michael N, additional, and Davey Smith, George, additional
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- 2019
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239. Loss-of-function genomic variants with impact on liver-related blood traits highlight potential therapeutic targets for cardiovascular disease
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Nielsen, Jonas B., primary, Rom, Oren, additional, Surakka, Ida, additional, Graham, Sarah E., additional, Zhou, Wei, additional, Fritsche, Lars G., additional, Gagliano Taliun, Sarah A., additional, Sidore, Carlo, additional, Liu, Yuhao, additional, Gabrielsen, Maiken E., additional, Skogholt, Anne Heidi, additional, Wolford, Brooke, additional, Overton, William, additional, Hornsby, Whitney E., additional, Acheampong, Akua, additional, Grooms, Austen, additional, Roychowdhury, Tanmoy, additional, Schaefer, Amanda, additional, Zajac, Gregory JM, additional, Villacorta, Luis, additional, Zhang, Jifeng, additional, Brumpton, Ben, additional, Løset, Mari, additional, Rai, Vivek, additional, Taylor, Kent D., additional, Palmer, Nicholette D., additional, Chen, Yii-Der, additional, Choi, Seung Hoan, additional, Lubitz, Steven A., additional, Ellinor, Patrick T., additional, Barnes, Kathleen C., additional, Daya, Michelle, additional, Rafaels, Nicholas, additional, Weiss, Scott T., additional, Lasky-Su, Jessica, additional, Tracy, Russell P., additional, Vasan, Ramachandran S., additional, Cupples, L. Adrienne, additional, Mathias, Rasika A., additional, Yanek, Lisa R., additional, Becker, Lewis C., additional, Peyser, Patricia A., additional, Bielak, Lawrence F., additional, Smith, Jennifer A., additional, Aslibekyan, Stella, additional, Hildalgo, Bertha A., additional, Arnett, Donna K., additional, Irvin, Marguerite R., additional, Wilson, James G., additional, Musani, Solomon K., additional, Correa, Adolfo, additional, Rich, Stephen S., additional, Guo, Xiuqing, additional, Rotter, Jerome I., additional, Konkle, Barbara A., additional, Johnsen, Jill M., additional, Ashley-Koch, Allison E., additional, Telen, Marilyn J., additional, Sheehan, Vivien A., additional, Blangero, John, additional, Curran, Joanne E., additional, Peralta, Juan M., additional, Montgomery, Courtney, additional, Sheu, Wayne H-H, additional, Chung, Ren-Hua, additional, Schwander, Karen, additional, Nouraie, Seyed M., additional, Gordeuk, Victor R., additional, Zhang, Yingze, additional, Kooperberg, Charles, additional, Reiner, Alexander P., additional, Jackson, Rebecca D., additional, Bleecker, Eugene R., additional, Meyers, Deborah A., additional, Li, Xingnan, additional, Das, Sayantan, additional, Yu, Ketian, additional, LeFaive, Jonathon, additional, Smith, Albert, additional, Blackwell, Tom, additional, Taliun, Daniel, additional, Zollner, Sebastian, additional, Forer, Lukas, additional, Schoenherr, Sebastian, additional, Fuchsberger, Christian, additional, Pandit, Anita, additional, Zawistowski, Matthew, additional, Kheterpal, Sachin, additional, Brummett, Chad M., additional, Natarajan, Pradeep, additional, Schlessinger, David, additional, Lee, Seunggeun, additional, Kang, Hyun Min, additional, Cucca, Francesco, additional, Holmen, Oddgeir L., additional, Åsvold, Bjørn O., additional, Boehnke, Michael, additional, Kathiresan, Sekar, additional, Abecasis, Goncalo, additional, Chen, Y. Eugene, additional, Willer, Cristen J., additional, and Hveem, Kristian, additional
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- 2019
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240. Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct
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Ferreira, Manuel A.R., primary, Mathur, Riddhima, additional, Vonk, Judith M., additional, Szwajda, Agnieszka, additional, Brumpton, Ben, additional, Granell, Raquel, additional, Brew, Bronwyn K., additional, Ullemar, Vilhelmina, additional, Lu, Yi, additional, Jiang, Yunxuan, additional, Magnusson, Patrik K.E., additional, Karlsson, Robert, additional, Hinds, David A., additional, Paternoster, Lavinia, additional, Koppelman, Gerard H., additional, and Almqvist, Catarina, additional
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- 2019
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241. Prolonged Sitting, Its Combination With Physical Inactivity and Incidence of Lung Cancer: Prospective Data From the HUNT Study
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Jiang, Lin, primary, Sun, Yi-Qian, additional, Brumpton, Ben Michael, additional, Langhammer, Arnulf, additional, Chen, Yue, additional, Nilsen, Tom I. L., additional, and Mai, Xiao-Mei, additional
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- 2019
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242. A saturated map of common genetic variants associated with human height
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Yengo, Loïc, Vedantam, Sailaja, Marouli, Eirini, Sidorenko, Julia, Bartell, Eric, Sakaue, Saori, Graff, Marielisa, Eliasen, Anders U., Jiang, Yunxuan, Raghavan, Sridharan, Miao, Jenkai, Arias, Joshua D., Graham, Sarah E., Mukamel, Ronen E., Spracklen, Cassandra N., Yin, Xianyong, Chen, Shyh-Huei, Ferreira, Teresa, Highland, Heather H., Ji, Yingjie, Karaderi, Tugce, Lin, Kuang, Lüll, Kreete, Malden, Deborah E., Medina-Gomez, Carolina, Machado, Moara, Moore, Amy, Rüeger, Sina, Sim, Xueling, Vrieze, Scott, Ahluwalia, Tarunveer S., Akiyama, Masato, Allison, Matthew A., Alvarez, Marcus, Andersen, Mette K., Ani, Alireza, Appadurai, Vivek, Arbeeva, Liubov, Bhaskar, Seema, Bielak, Lawrence F., Bollepalli, Sailalitha, Bonnycastle, Lori L., Bork-Jensen, Jette, Bradfield, Jonathan P., Bradford, Yuki, Braund, Peter S., Brody, Jennifer A., Burgdorf, Kristoffer S., Cade, Brian E., Cai, Hui, Cai, Qiuyin, Campbell, Archie, Cañadas-Garre, Marisa, Catamo, Eulalia, Chai, Jin-Fang, Chai, Xiaoran, Chang, Li-Ching, Chang, Yi-Cheng, Chen, Chien-Hsiun, Chesi, Alessandra, Choi, Seung Hoan, Chung, Ren-Hua, Cocca, Massimiliano, Concas, Maria Pina, Couture, Christian, Cuellar-Partida, Gabriel, Danning, Rebecca, Daw, E. Warwick, Degenhard, Frauke, Delgado, Graciela E., Delitala, Alessandro, Demirkan, Ayse, Deng, Xuan, Devineni, Poornima, Dietl, Alexander, Dimitriou, Maria, Dimitrov, Latchezar, Dorajoo, Rajkumar, Ekici, Arif B., Engmann, Jorgen E., Fairhurst-Hunter, Zammy, Farmaki, Aliki-Eleni, Faul, Jessica D., Fernandez-Lopez, Juan-Carlos, Forer, Lukas, Francescatto, Margherita, Freitag-Wolf, Sandra, Fuchsberger, Christian, Galesloot, Tessel E., Gao, Yan, Gao, Zishan, Geller, Frank, Giannakopoulou, Olga, Giulianini, Franco, Gjesing, Anette P., Goel, Anuj, Gordon, Scott D., Gorski, Mathias, Grove, Jakob, Guo, Xiuqing, Gustafsson, Stefan, Haessler, Jeffrey, Hansen, Thomas F., Havulinna, Aki S., Haworth, Simon J., He, Jing, Heard-Costa, Nancy, Hebbar, Prashantha, Hindy, George, Ho, Yuk-Lam A., Hofer, Edith, Holliday, Elizabeth, Horn, Katrin, Hornsby, Whitney E., Hottenga, Jouke-Jan, Huang, Hongyan, Huang, Jie, Huerta-Chagoya, Alicia, Huffman, Jennifer E., Hung, Yi-Jen, Huo, Shaofeng, Hwang, Mi Yeong, Iha, Hiroyuki, Ikeda, Daisuke D., Isono, Masato, Jackson, Anne U., Jäger, Susanne, Jansen, Iris E., Johansson, Ingegerd, Jonas, Jost B., Jonsson, Anna, Jørgensen, Torben, Kalafati, Ioanna-Panagiota, Kanai, Masahiro, Kanoni, Stavroula, Kårhus, Line L., Kasturiratne, Anuradhani, Katsuya, Tomohiro, Kawaguchi, Takahisa, Kember, Rachel L., Kentistou, Katherine A., Kim, Han-Na, Kim, Young Jin, Kleber, Marcus E., Knol, Maria J., Kurbasic, Azra, Lauzon, Marie, Le, Phuong, Lea, Rodney, Lee, Jong-Young, Leonard, Hampton L., Li, Shengchao A., Li, Xiaohui, Li, Xiaoyin, Liang, Jingjing, Lin, Honghuang, Lin, Shih-Yi, Liu, Jun, Liu, Xueping, Lo, Ken Sin, Long, Jirong, Lores-Motta, Laura, Luan, Jian’an, Lyssenko, Valeriya, Lyytikäinen, Leo-Pekka, Mahajan, Anubha, Mamakou, Vasiliki, Mangino, Massimo, Manichaikul, Ani, Marten, Jonathan, Mattheisen, Manuel, Mavarani, Laven, McDaid, Aaron F., Meidtner, Karina, Melendez, Tori L., Mercader, Josep M., Milaneschi, Yuri, Miller, Jason E., Millwood, Iona Y., Mishra, Pashupati P., Mitchell, Ruth E., Møllehave, Line T., Morgan, Anna, Mucha, Soeren, Munz, Matthias, Nakatochi, Masahiro, Nelson, Christopher P., Nethander, Maria, Nho, Chu Won, Nielsen, Aneta A., Nolte, Ilja M., Nongmaithem, Suraj S., Noordam, Raymond, Ntalla, Ioanna, Nutile, Teresa, Pandit, Anita, Christofidou, Paraskevi, Pärna, Katri, Pauper, Marc, Petersen, Eva R. B., Petersen, Liselotte V., Pitkänen, Niina, Polašek, Ozren, Poveda, Alaitz, Preuss, Michael H., Pyarajan, Saiju, Raffield, Laura M., Rakugi, Hiromi, Ramirez, Julia, Rasheed, Asif, Raven, Dennis, Rayner, Nigel W., Riveros, Carlos, Rohde, Rebecca, Ruggiero, Daniela, Ruotsalainen, Sanni E., Ryan, Kathleen A., Sabater-Lleal, Maria, Saxena, Richa, Scholz, Markus, Sendamarai, Anoop, Shen, Botong, Shi, Jingchunzi, Shin, Jae Hun, Sidore, Carlo, Sitlani, Colleen M., Slieker, Roderick C., Smit, Roelof A. J., Smith, Albert V., Smith, Jennifer A., Smyth, Laura J., Southam, Lorraine, Steinthorsdottir, Valgerdur, Sun, Liang, Takeuchi, Fumihiko, Tallapragada, Divya Sri Priyanka, Taylor, Kent D., Tayo, Bamidele O., Tcheandjieu, Catherine, Terzikhan, Natalie, Tesolin, Paola, Teumer, Alexander, Theusch, Elizabeth, Thompson, Deborah J., Thorleifsson, Gudmar, Timmers, Paul R. H. J., Trompet, Stella, Turman, Constance, Vaccargiu, Simona, van der Laan, Sander W., van der Most, Peter J., van Klinken, Jan B., van Setten, Jessica, Verma, Shefali S., Verweij, Niek, Veturi, Yogasudha, Wang, Carol A., Wang, Chaolong, Wang, Lihua, Wang, Zhe, Warren, Helen R., Bin Wei, Wen, Wickremasinghe, Ananda R., Wielscher, Matthias, Wiggins, Kerri L., Winsvold, Bendik S., Wong, Andrew, Wu, Yang, Wuttke, Matthias, Xia, Rui, Xie, Tian, Yamamoto, Ken, Yang, Jingyun, Yao, Jie, Young, Hannah, Yousri, Noha A., Yu, Lei, Zeng, Lingyao, Zhang, Weihua, Zhang, Xinyuan, Zhao, Jing-Hua, Zhao, Wei, Zhou, Wei, Zimmermann, Martina E., Zoledziewska, Magdalena, Adair, Linda S., Adams, Hieab H. H., Aguilar-Salinas, Carlos A., Al-Mulla, Fahd, Arnett, Donna K., Asselbergs, Folkert W., Åsvold, Bjørn Olav, Attia, John, Banas, Bernhard, Bandinelli, Stefania, Bennett, David A., Bergler, Tobias, Bharadwaj, Dwaipayan, Biino, Ginevra, Bisgaard, Hans, Boerwinkle, Eric, Böger, Carsten A., Bønnelykke, Klaus, Boomsma, Dorret I., Børglum, Anders D., Borja, Judith B., Bouchard, Claude, Bowden, Donald W., Brandslund, Ivan, Brumpton, Ben, Buring, Julie E., Caulfield, Mark J., Chambers, John C., Chandak, Giriraj R., Chanock, Stephen J., Chaturvedi, Nish, Chen, Yii-Der Ida, Chen, Zhengming, Cheng, Ching-Yu, Christophersen, Ingrid E., Ciullo, Marina, Cole, John W., Collins, Francis S., Cooper, Richard S., Cruz, Miguel, Cucca, Francesco, Cupples, L. Adrienne, Cutler, Michael J., Damrauer, Scott M., Dantoft, Thomas M., de Borst, Gert J., de Groot, Lisette C. P. G. M., De Jager, Philip L., de Kleijn, Dominique P. V., Janaka de Silva, H., Dedoussis, George V., den Hollander, Anneke I., Du, Shufa, Easton, Douglas F., Elders, Petra J. M., Eliassen, A. Heather, Ellinor, Patrick T., Elmståhl, Sölve, Erdmann, Jeanette, Evans, Michele K., Fatkin, Diane, Feenstra, Bjarke, Feitosa, Mary F., Ferrucci, Luigi, Ford, Ian, Fornage, Myriam, Franke, Andre, Franks, Paul W., Freedman, Barry I., Gasparini, Paolo, Gieger, Christian, Girotto, Giorgia, Goddard, Michael E., Golightly, Yvonne M., Gonzalez-Villalpando, Clicerio, Gordon-Larsen, Penny, Grallert, Harald, Grant, Struan F. A., Grarup, Niels, Griffiths, Lyn, Gudnason, Vilmundur, Haiman, Christopher, Hakonarson, Hakon, Hansen, Torben, Hartman, Catharina A., Hattersley, Andrew T., Hayward, Caroline, Heckbert, Susan R., Heng, Chew-Kiat, Hengstenberg, Christian, Hewitt, Alex W., Hishigaki, Haretsugu, Hoyng, Carel B., Huang, Paul L., Huang, Wei, Hunt, Steven C., Hveem, Kristian, Hyppönen, Elina, Iacono, William G., Ichihara, Sahoko, Ikram, M. Arfan, Isasi, Carmen R., Jackson, Rebecca D., Jarvelin, Marjo-Riitta, Jin, Zi-Bing, Jöckel, Karl-Heinz, Joshi, Peter K., Jousilahti, Pekka, Jukema, J. Wouter, Kähönen, Mika, Kamatani, Yoichiro, Kang, Kui Dong, Kaprio, Jaakko, Kardia, Sharon L. R., Karpe, Fredrik, Kato, Norihiro, Kee, Frank, Kessler, Thorsten, Khera, Amit V., Khor, Chiea Chuen, Kiemeney, Lambertus A. L. M., Kim, Bong-Jo, Kim, Eung Kweon, Kim, Hyung-Lae, Kirchhof, Paulus, Kivimaki, Mika, Koh, Woon-Puay, Koistinen, Heikki A., Kolovou, Genovefa D., Kooner, Jaspal S., Kooperberg, Charles, Köttgen, Anna, Kovacs, Peter, Kraaijeveld, Adriaan, Kraft, Peter, Krauss, Ronald M., Kumari, Meena, Kutalik, Zoltan, Laakso, Markku, Lange, Leslie A., Langenberg, Claudia, Launer, Lenore J., Le Marchand, Loic, Lee, Hyejin, Lee, Nanette R., Lehtimäki, Terho, Li, Huaixing, Li, Liming, Lieb, Wolfgang, Lin, Xu, Lind, Lars, Linneberg, Allan, Liu, Ching-Ti, Liu, Jianjun, Loeffler, Markus, London, Barry, Lubitz, Steven A., Lye, Stephen J., Mackey, David A., Mägi, Reedik, Magnusson, Patrik K. E., Marcus, Gregory M., Vidal, Pedro Marques, Martin, Nicholas G., März, Winfried, Matsuda, Fumihiko, McGarrah, Robert W., McGue, Matt, McKnight, Amy Jayne, Medland, Sarah E., Mellström, Dan, Metspalu, Andres, Mitchell, Braxton D., Mitchell, Paul, Mook-Kanamori, Dennis O., Morris, Andrew D., Mucci, Lorelei A., Munroe, Patricia B., Nalls, Mike A., Nazarian, Saman, Nelson, Amanda E., Neville, Matt J., Newton-Cheh, Christopher, Nielsen, Christopher S., Nöthen, Markus M., Ohlsson, Claes, Oldehinkel, Albertine J., Orozco, Lorena, Pahkala, Katja, Pajukanta, Päivi, Palmer, Colin N. A., Parra, Esteban J., Pattaro, Cristian, Pedersen, Oluf, Pennell, Craig E., Penninx, Brenda W. J. H., Perusse, Louis, Peters, Annette, Peyser, Patricia A., Porteous, David J., Posthuma, Danielle, Power, Chris, Pramstaller, Peter P., Province, Michael A., Qi, Qibin, Qu, Jia, Rader, Daniel J., Raitakari, Olli T., Ralhan, Sarju, Rallidis, Loukianos S., Rao, Dabeeru C., Redline, Susan, Reilly, Dermot F., Reiner, Alexander P., Rhee, Sang Youl, Ridker, Paul M., Rienstra, Michiel, Ripatti, Samuli, Ritchie, Marylyn D., Roden, Dan M., Rosendaal, Frits R., Rotter, Jerome I., Rudan, Igor, Rutters, Femke, Sabanayagam, Charumathi, Saleheen, Danish, Salomaa, Veikko, Samani, Nilesh J., Sanghera, Dharambir K., Sattar, Naveed, Schmidt, Börge, Schmidt, Helena, Schmidt, Reinhold, Schulze, Matthias B., Schunkert, Heribert, Scott, Laura J., Scott, Rodney J., Sever, Peter, Shiroma, Eric J., Shoemaker, M. Benjamin, Shu, Xiao-Ou, Simonsick, Eleanor M., Sims, Mario, Singh, Jai Rup, Singleton, Andrew B., Sinner, Moritz F., Smith, J. Gustav, Snieder, Harold, Spector, Tim D., Stampfer, Meir J., Stark, Klaus J., Strachan, David P., ‘t Hart, Leen M., Tabara, Yasuharu, Tang, Hua, Tardif, Jean-Claude, Thanaraj, Thangavel A., Timpson, Nicholas J., Tönjes, Anke, Tremblay, Angelo, Tuomi, Tiinamaija, Tuomilehto, Jaakko, Tusié-Luna, Maria-Teresa, Uitterlinden, Andre G., van Dam, Rob M., van der Harst, Pim, Van der Velde, Nathalie, van Duijn, Cornelia M., van Schoor, Natasja M., Vitart, Veronique, Völker, Uwe, Vollenweider, Peter, Völzke, Henry, Wacher-Rodarte, Niels H., Walker, Mark, Wang, Ya Xing, Wareham, Nicholas J., Watanabe, Richard M., Watkins, Hugh, Weir, David R., Werge, Thomas M., Widen, Elisabeth, Wilkens, Lynne R., Willemsen, Gonneke, Willett, Walter C., Wilson, James F., Wong, Tien-Yin, Woo, Jeong-Taek, Wright, Alan F., Wu, Jer-Yuarn, Xu, Huichun, Yajnik, Chittaranjan S., Yokota, Mitsuhiro, Yuan, Jian-Min, Zeggini, Eleftheria, Zemel, Babette S., Zheng, Wei, Zhu, Xiaofeng, Zmuda, Joseph M., Zonderman, Alan B., Zwart, John-Anker, Chasman, Daniel I., Cho, Yoon Shin, Heid, Iris M., McCarthy, Mark I., Ng, Maggie C. Y., O’Donnell, Christopher J., Rivadeneira, Fernando, Thorsteinsdottir, Unnur, Sun, Yan V., Tai, E. Shyong, Boehnke, Michael, Deloukas, Panos, Justice, Anne E., Lindgren, Cecilia M., Loos, Ruth J. F., Mohlke, Karen L., North, Kari E., Stefansson, Kari, Walters, Robin G., Winkler, Thomas W., Young, Kristin L., Loh, Po-Ru, Yang, Jian, Esko, Tõnu, Assimes, Themistocles L., Auton, Adam, Abecasis, Goncalo R., Willer, Cristen J., Locke, Adam E., Berndt, Sonja I., Lettre, Guillaume, Frayling, Timothy M., Okada, Yukinori, Wood, Andrew R., Visscher, Peter M., and Hirschhorn, Joel N.
- Abstract
Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40–50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes1. Here, using data from a genome-wide association study of 5.4 million individuals of diverse ancestries, we show that 12,111 independent SNPs that are significantly associated with height account for nearly all of the common SNP-based heritability. These SNPs are clustered within 7,209 non-overlapping genomic segments with a mean size of around 90 kb, covering about 21% of the genome. The density of independent associations varies across the genome and the regions of increased density are enriched for biologically relevant genes. In out-of-sample estimation and prediction, the 12,111 SNPs (or all SNPs in the HapMap 3 panel2) account for 40% (45%) of phenotypic variance in populations of European ancestry but only around 10–20% (14–24%) in populations of other ancestries. Effect sizes, associated regions and gene prioritization are similar across ancestries, indicating that reduced prediction accuracy is likely to be explained by linkage disequilibrium and differences in allele frequency within associated regions. Finally, we show that the relevant biological pathways are detectable with smaller sample sizes than are needed to implicate causal genes and variants. Overall, this study provides a comprehensive map of specific genomic regions that contain the vast majority of common height-associated variants. Although this map is saturated for populations of European ancestry, further research is needed to achieve equivalent saturation in other ancestries.
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- 2022
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243. Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles
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Hautakangas, Heidi, Winsvold, Bendik S., Ruotsalainen, Sanni E., Bjornsdottir, Gyda, Harder, Aster V. E., Kogelman, Lisette J. A., Thomas, Laurent F., Noordam, Raymond, Benner, Christian, Gormley, Padhraig, Artto, Ville, Banasik, Karina, Bjornsdottir, Anna, Boomsma, Dorret I., Brumpton, Ben M., Burgdorf, Kristoffer Sølvsten, Buring, Julie E., Chalmer, Mona Ameri, de Boer, Irene, Dichgans, Martin, Erikstrup, Christian, Färkkilä, Markus, Garbrielsen, Maiken Elvestad, Ghanbari, Mohsen, Hagen, Knut, Häppölä, Paavo, Hottenga, Jouke-Jan, Hrafnsdottir, Maria G., Hveem, Kristian, Johnsen, Marianne Bakke, Kähönen, Mika, Kristoffersen, Espen S., Kurth, Tobias, Lehtimäki, Terho, Lighart, Lannie, Magnusson, Sigurdur H., Malik, Rainer, Pedersen, Ole Birger, Pelzer, Nadine, Penninx, Brenda W. J. H., Ran, Caroline, Ridker, Paul M., Rosendaal, Frits R., Sigurdardottir, Gudrun R., Skogholt, Anne Heidi, Sveinsson, Olafur A., Thorgeirsson, Thorgeir E., Ullum, Henrik, Vijfhuizen, Lisanne S., Widén, Elisabeth, van Dijk, Ko Willems, Aromaa, Arpo, Belin, Andrea Carmine, Freilinger, Tobias, Ikram, M. Arfan, Järvelin, Marjo-Riitta, Raitakari, Olli T., Terwindt, Gisela M., Kallela, Mikko, Wessman, Maija, Olesen, Jes, Chasman, Daniel I., Nyholt, Dale R., Stefánsson, Hreinn, Stefansson, Kari, van den Maagdenberg, Arn M. J. M., Hansen, Thomas Folkmann, Ripatti, Samuli, Zwart, John-Anker, Palotie, Aarno, and Pirinen, Matti
- Abstract
Migraine affects over a billion individuals worldwide but its genetic underpinning remains largely unknown. Here, we performed a genome-wide association study of 102,084 migraine cases and 771,257 controls and identified 123 loci, of which 86 are previously unknown. These loci provide an opportunity to evaluate shared and distinct genetic components in the two main migraine subtypes: migraine with aura and migraine without aura. Stratification of the risk loci using 29,679 cases with subtype information indicated three risk variants that seem specific for migraine with aura (in HMOX2, CACNA1Aand MPPED2), two that seem specific for migraine without aura (near SPINK2and near FECH) and nine that increase susceptibility for migraine regardless of subtype. The new risk loci include genes encoding recent migraine-specific drug targets, namely calcitonin gene-related peptide (CALCA/CALCB) and serotonin 1F receptor (HTR1F). Overall, genomic annotations among migraine-associated variants were enriched in both vascular and central nervous system tissue/cell types, supporting unequivocally that neurovascular mechanisms underlie migraine pathophysiology.
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- 2022
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244. Sex- and age-specific genetic analysis of chronic back pain.
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Freidin, Maxim B., Tsepilov, Yakov A., Stanaway, Ian B., Meng, Weihua, Hayward, Caroline, Smith, Blair H., Khoury, Samar, Parisien, Marc, Bortsov, Andrey, Diatchenko, Luda, Børte, Sigrid, Winsvold, Bendik S., Brumpton, Ben M., Zwart, John-Anker, Aulchenko, Yurii S., Suri, Pradeep, Williams, Frances M. K., and HUNT All-In Pain
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- 2021
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245. COL11A1is associated with developmental dysplasia of the hip and secondary osteoarthritis in the HUNT study
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Jacobsen, Kaya Kvarme, Børte, Sigrid, Laborie, Lene Bjerke, Kristiansen, Hege, Schäfer, Annette, Martinsen, Amy E., Skogholt, Anne Heidi, Brumpton, Ben M., Willer, Cristen J., Fors, Egil A., Kristoffersen, Espen S., Heuch, Ingrid, Mundal, Ingunn, Zwart, John-Anker, Nielsen, Jonas B., Storheim, Kjersti, Hagen, Knut, Nilsen, Kristian Bernhard, Hveem, Kristian, Fritsche, Lars G., Thomas, Laurent F., Pedersen, Linda M., Gabrielsen, Maiken E., Lie, Marie U., Stensland, Synne Ø., Zhou, Wei, Gundersen, Trude, Zayats, Tetyana, Slagsvold Winsvold, Bendik Kristoffer, and Rosendahl, Karen
- Abstract
Developmental dysplasia of the hip (DDH) is a congenital condition affecting 2–3% of all infants. DDH increases the risk of osteoarthritis, is the cause of 30 % of all total hip arthroplasties (THAs) in adults <40 years of age and can result in loss of life quality. Our aim was to explore the genetic background of DDH in order to improve diagnosis, management and longterm outcome.
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- 2024
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246. Avoiding dynastic, assortative mating, and population stratification biases in Mendelian randomization through within-family analyses.
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Brumpton, Ben, Sanderson, Eleanor, Heilbron, Karl, Hartwig, Fernando Pires, Harrison, Sean, Vie, Gunnhild Åberge, Cho, Yoonsu, Howe, Laura D., Hughes, Amanda, Boomsma, Dorret I., Havdahl, Alexandra, Hopper, John, Neale, Michael, Nivard, Michel G., Pedersen, Nancy L., Reynolds, Chandra A., Tucker-Drob, Elliot M., Grotzinger, Andrew, Howe, Laurence, and Morris, Tim
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ASSORTATIVE mating ,RANDOMIZATION (Statistics) ,HYPERTENSION ,EDUCATIONAL attainment - Abstract
Estimates from Mendelian randomization studies of unrelated individuals can be biased due to uncontrolled confounding from familial effects. Here we describe methods for within-family Mendelian randomization analyses and use simulation studies to show that family-based analyses can reduce such biases. We illustrate empirically how familial effects can affect estimates using data from 61,008 siblings from the Nord-Trøndelag Health Study and UK Biobank and replicated our findings using 222,368 siblings from 23andMe. Both Mendelian randomization estimates using unrelated individuals and within family methods reproduced established effects of lower BMI reducing risk of diabetes and high blood pressure. However, while Mendelian randomization estimates from samples of unrelated individuals suggested that taller height and lower BMI increase educational attainment, these effects were strongly attenuated in within-family Mendelian randomization analyses. Our findings indicate the necessity of controlling for population structure and familial effects in Mendelian randomization studies. Family-based study designs have been applied to resolve confounding by population stratification, dynastic effects and assortative mating in genetic association analyses. Here, Brumpton et al. describe theory and simulations for overcoming such biases in Mendelian randomization through within-family studies. [ABSTRACT FROM AUTHOR]
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- 2020
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247. Comparison of pre‐ and post‐bronchodilator lung function as predictors of mortality: The HUNT Study.
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Bhatta, Laxmi, Leivseth, Linda, Carslake, David, Langhammer, Arnulf, Mai, Xiao‐Mei, Chen, Yue, Henriksen, Anne H., and Brumpton, Ben M.
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OBSTRUCTIVE lung diseases ,RECEIVER operating characteristic curves ,LUNGS ,MORTALITY - Abstract
Background and objective: Post‐bronchodilator (BD) lung function is recommended for the diagnosis of chronic obstructive pulmonary disease (COPD). However, often only pre‐BD lung function is used in clinical practice or epidemiological studies. We aimed to compare the discrimination ability of pre‐BD and post‐BD lung function to predict all‐cause mortality. Methods: Participants aged ≥40 years with airflow limitation (n = 2538) and COPD (n = 1262) in the second survey of the Nord‐Trøndelag Health Study (HUNT2, 1995–1997) were followed up until 31 December 2015. Survival analysis and time‐dependent area under the receiver operating characteristic curves (AUC) were used to compare the discrimination ability of pre‐BD and post‐BD lung function (percent‐predicted forced expiratory volume in the first second (FEV1) (ppFEV1), FEV1 z‐score, FEV1 quotient (FEV1Q), modified Global Initiative for Chronic Obstructive Lung Disease (GOLD) categories or GOLD grades). Results: Among 2538 participants, 1387 died. The AUC for pre‐BD and post‐BD ppFEV1 to predict mortality were 60.8 and 61.8 (P = 0.005), respectively, at 20 years' follow‐up. The corresponding AUC for FEV1 z‐score were 58.5 and 60.4 (P < 0.001), for FEV1Q were 68.7 and 70.1 (P = 0.002) and for modified GOLD categories were 62.3 and 64.5 (P < 0.001). Among participants with COPD, the AUC for pre‐BD and post‐BD ppFEV1 were 57.0 and 58.8 (P < 0.001), respectively. The corresponding AUC for FEV1 z‐score were 53.1 and 55.8 (P < 0.001), for FEV1Q were 63.6 and 65.1 (P = 0.037) and for GOLD grades were 56.0 and 57.0 (P = 0.268). Conclusion: Mortality was better predicted by post‐BD than by pre‐BD lung function; however, they differed only by a small margin. The discrimination ability using GOLD grades among COPD participants was similar. Few previous studies have compared the discrimination ability of pre‐BD and post‐BD lung function in predicting mortality. We found post‐BD is slightly better than pre‐BD to predict mortality using percent‐predicted forced expiratory volume in the first second (FEV1), FEV1 z‐score, FEV1 quotient (FEV1Q) or modified Global Initiative for Chronic Obstructive Lung Disease (GOLD) categories. However, among people with chronic obstructive pulmonary disease (COPD), mortality was similarly predicted using GOLD grades. [ABSTRACT FROM AUTHOR]
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- 2020
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248. Adiposity and asthma in adults: a bidirectional Mendelian randomisation analysis of The HUNT Study.
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Yi-Qian, Brumpton, Ben Michael, Langhammer, Arnulf, Yue Chen, Kvaløy, Kirsti, Xiao-Mei, Sun, Yi-Qian, Chen, Yue, and Mai, Xiao-Mei
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ATOPY ,ASTHMA ,WAIST-hip ratio ,BODY mass index ,OBESITY ,SINGLE nucleotide polymorphisms ,RESEARCH ,SEQUENCE analysis ,RESEARCH methodology ,GENETIC polymorphisms ,EVALUATION research ,MEDICAL cooperation ,SEX distribution ,COMPARATIVE studies ,DISEASE prevalence ,ALLERGIES ,ADIPOSE tissues - Abstract
Background: We aimed to investigate the potential causal associations of adiposity with asthma overall, asthma by atopic status or by levels of symptom control in a large adult population and stratified by sex. We also investigated the potential for reverse causation between asthma and risk of adiposity.Methods: We performed a bidirectional one-sample Mendelian randomisation (MR) study using the Norwegian Nord-Trøndelag Health Study population including 56 105 adults. 73 and 47 genetic variants were included as instrumental variables for body mass index (BMI) and waist-to-hip ratio (WHR), respectively. Asthma was defined as ever asthma, doctor-diagnosed asthma and doctor-diagnosed active asthma, and was further classified by atopic status or levels of symptom control. Causal OR was calculated with the Wald method.Results: The ORs per 1 SD (4.1 kg/m2) increase in genetically determined BMI were ranged from 1.36 to 1.49 for the three asthma definitions and similar for women and men. The corresponding ORs for non-atopic asthma (range 1.42-1.72) appeared stronger than those for the atopic asthma (range 1.18-1.26), but they were similar for controlled versus partly controlled doctor-diagnosed active asthma (1.43 vs 1.44). There was no clear association between genetically predicted WHR and asthma risk or between genetically predicted asthma and the adiposity markers.Conclusions: Our MR study provided evidence of a causal association of BMI with asthma in adults, particularly with non-atopic asthma. There was no clear evidence of a causal link between WHR and asthma or of reverse causation. [ABSTRACT FROM AUTHOR]- Published
- 2020
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249. Investigating causal relationships between sleep traits and risk of breast cancer: a Mendelian randomization study
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Richmond, Rebecca C., primary, Anderson, Emma L., additional, Dashti, Hassan S., additional, Jones, Samuel E., additional, Lane, Jacqueline M., additional, Strand, Linn Beate, additional, Brumpton, Ben, additional, Rutter, Martin, additional, Wood, Andrew R., additional, Relton, Caroline L., additional, Munafò, Marcus, additional, Frayling, Timothy M., additional, Martin, Richard M., additional, Saxena, Richa, additional, Weedon, Michael N., additional, Lawlor, Debbie A., additional, and Davey Smith, George, additional
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- 2018
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250. Genome-wide association analysis of excessive daytime sleepiness identifies 42 loci that suggest phenotypic subgroups
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Wang, Heming, primary, Lane, Jacqueline M, additional, Jones, Samuel E, additional, Dashti, Hassan S, additional, Ollila, Hanna, additional, Wood, Andrew R, additional, van Hees, Vincent T., additional, Brumpton, Ben, additional, Winsvold, Bendik S, additional, Kantojärvi, Katri, additional, Cade, Brian E, additional, Sofer, Tamar, additional, Song, Yanwei, additional, Patel, Krunal, additional, Anderson, Simon G, additional, Bechtold, David A, additional, Bowden, Jack, additional, Emsley, Richard, additional, Kyle, Simon D, additional, Little, Max A, additional, Loudon, Andrew S, additional, Scheer, Frank AJL, additional, Purcell, Shaun M, additional, Richmond, Rebecca C, additional, Spiegelhalder, Kai, additional, Tyrrell, Jessica, additional, Zhu, Xiaofeng, additional, Kristiansson, Kati, additional, Sulkava, Sonja, additional, Paunio, Tiina, additional, Hveem, Kristian, additional, Nielsen, Jonas B, additional, Willer, Cristen J, additional, Zwart, John-Anker, additional, Strand, Linn B, additional, Frayling, Timothy M, additional, Ray, David, additional, Lawlor, Deborah A, additional, Rutter, Martin K, additional, Weedon, Michael N, additional, Redline, Susan, additional, and Saxena, Richa, additional
- Published
- 2018
- Full Text
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