Author: "Brear P" - Searchworks@Jio Institute Digital Library Search Results

346 results on '"Brear P"'

201. Experimental and numerical study of a spark ignition engine with air-assisted direct injection.

Author: Boretti, A, Jin, S-H, Brear, M, Zakis, G, Attard, W, Watson, H, Brewster, S, and Bryce, W
Subjects: FUEL systems, SPARK ignition engines, FUEL pump design & construction, AUTOMOBILE engines, AUTOMOBILE emission control devices, EMISSIONS (Air pollution), ELECTRIC equipment
Abstract: An experimental and numerical study of the spray from an air-assisted fuel injector in a direct-injection spark ignition (DISI) engine is presented. The experiments are performed using ultraviolet laser diagnostics in a motoring optical engine that is a DISI variant of a production port-fuel-injected engine. Non-optical single-cylinder firing engine results of experiments and simulations are also presented. Recent related work by the present authors has shown that, under design conditions, the air-assisted injector exhibits strong coupling between the liquid and gas phases. It results in a filled-in conical spray of relatively fine atomization and low penetration, with liquid and vapour fuel concentrations close to the centrally located injector and spark plug, as required for lean stratified operation. This paper shows the strong effect of increasing the chamber temperature on spray evaporation and penetration. This observed temperature effect shows that spray evaporation should vary significantly during cold start. Exhaust gas recirculation (EGR) may also have a beneficial effect on DISI engine performance through enhanced spray evaporation, although this is difficult to verify experimentally. If true, this effect of EGR is a separate mechanism to the known beneficial effects of EGR in air-assisted DISI engines. [ABSTRACT FROM AUTHOR]
Published: 2008
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202. Living with creep damage... outside the creep range.

Author: Brear, J. M. and Jarvis, P.
Subjects: NUCLEAR facilities, NUCLEAR energy, ELECTRIC utilities, ELECTRIC power production, MECHANICAL behavior of materials
Abstract: The present paper addresses the effects of creep cavitation damage on other mechanical properties – chiefly those that affect behaviour outside the creep range. Such effects seem not to have been systematically studied, yet they are significant for the understanding and prediction of component integrity and life. The paper presents results obtained mainly as byproducts of research programmes on low alloy steels for both fossil and nuclear power plant and seeks to rationalise the findings to generate an overall picture of the effect. It is seen that a simple loss of effective section model is adequate to describe many of the phenomena observed, but that other factors may also need consideration. [ABSTRACT FROM AUTHOR]
Published: 2007
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203. Propulsion System Requirements for Long Range, Supersonic Aircraft.

Author: Brear, Michael J., Karrebrock, Jack L., and Epstein, Alan H.
Subjects: SUPERSONIC planes, SUPERSONIC aerodynamics, PROPULSION systems, ENERGY consumption, TURBINES
Abstract: This paper discusses the requirements for the propulsion system of supersonic cruise aircraft that are quiet enough to fly over land and operate from civil airports, have trans-pacific range in the order of 11,112 km (6000 nmi), and payload in the order of 4545 kg (10,000 lb.). It is concluded that the resulting requirements for both the fuel consumption and engine thrust/weight ratio for such aircraft will require high compressor exit and turbine inlet temperatures, together with bypass ratios that are significantly higher than typical supersonic-capable engines. Several technologies for improving both the fuel consumption and weight of the propulsion system are suggested. Some of these directly reduce engine weight while others, by improving individual component performance, will enable higher bypass ratios. The latter should therefore also indirectly reduce the bare engine weight. It is emphasized, however, that these specific technologies require considerable further development. While the use of higher bypass ratio is a significant departure from more usual engines designed for supersonic cruise, it is nonetheless considered to be a practical option for an aircraft of this kind. [ABSTRACT FROM AUTHOR]
Published: 2006
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204. Flow Separation Within the Engine Inlet of an Uninhabited Combat Air Vehicle (UCAV).

Author: Brear, Michael J., Warfield, Zachary, Mangus, John F., Paduano, James D., Philhower, Jeffry S., and Braddom, Steve
Subjects: AIRPLANE motors, UNINHABITED combat aerial vehicles, AERODYNAMICS, FLUID dynamics, DRONE aircraft
Abstract: This paper discusses the structure of the flow within the engine inlet of an uninhabited combat air vehicle (UCAV). The UCAV features a top-mounted, serpentine inlet leading to an engine buried within the fuselage. The performance of the inlet is found to depend strongly on a flow separation that occurs within the inlet. Both the time-averaged and the unsteady structure of this separation is studied, and an argument relating the inlet performance to the behavior of this separation is suggested. The results presented in this paper also suggest that there are considerable aerodynamic limitations to further shortening or narrowing of the inlet. Since there are substantial, system level benefits from using a smaller inlet, the case for separated flow control therefore appears clear. [ABSTRACT FROM AUTHOR]
Published: 2004
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205. The Effect of Wake Passing on a Flow Separation in a Low-Pressure Turbine Cascade.

Author: Brear, Michael J. and Hodson, Howard P.
Subjects: WAKES (Fluid dynamics), TURBINES, VORTEX motion, FLUID dynamics, BUBBLES, DYNAMICS
Abstract: This paper describes an investigation into the effect that passing wakes have on a separation bubble that exists on the pressure surface and near the leading edge of a low-pressure turbine blade. Previous experimental studies have shown that the behavior of this separation is strongly incidence dependent and that it responds to its disturbance environment. The results presented in this paper examine the effect of wake passing in greater detail. Two-dimensional, Reynolds averaged, numerical predictions are first used to examine qualitatively the unsteady interaction between the wakes and the separation bubble. The separation is predicted to consist of spanwise vortices whose development is in phase with the wake passing. However, comparison with experiments shows that the numerical predictions exaggerate the coherence of these vortices and also overpredict the time-averaged length of the separation. Nonetheless, experiments strongly suggest that the predicted phase locking of the vortices in the separation onto the wake passing is physical. [ABSTRACT FROM AUTHOR]
Published: 2004
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206. A Robust Model Predictive Control Framework for Diesel Generators

Author: Broomhead, Timothy, Manzie, Chris, Eriksson, Lars, Brear, Michael, and Hield, Peter
Abstract: A constraint tightened linear-time-varying MPC framework is proposed with applications in power tracking for variable and fixed speed generators. Current constraint tightening approaches are extended to allow for practical applications where future system representations are unknown. The resulting control structure is shown to be robustly feasible under given conditions. Knowledge about the geometry of system constraints is exploited to obtain a computationally efficient method of computing tightened sets online. A simulation study is presented demonstrating the ability of the controller to handle modelling error and demonstrate tracking of a commanded power profile.
Published: 2014
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207. Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Author: Abaleke, Eugenia, Abbas, Mustafa, Abbasi, Sadia, Abbott, Alfie, Abdelaziz, Ashraf, Abdelbadiee, Sherif, Abdelfattah, Mohamed, Abdul, Basir, Abdul Rasheed, Althaf, Abdul-Kadir, Rezan, Abdulmumeen, Abdulfatahi, Abdulshukkoor, Niyaz, Abdusamad, Kula, Abed El Khaleq, Yazeed, Abedalla, Mai, Abeer Ul Amna, Abeer UA, Aboaba, Adebanke, Abo-Leyah, Hani, Abou-Haggar, Ahmed, Abouibrahim, Mahmoud, Abraham, Miriam, Abraham, Tizzy, Abraheem, Abraheem, Abrams, Judith, Abu, Hyacinth-John, Abu-Arafeh, Ahmad, Abubacker, Syed M, Abung, Akata, Aceampong, Yaa, Acharya, Devikumar, Acheson, Janet, Acosta, Andres, Acton, Catherine, Adabie-Ankrah, Jacqueline, Adam, Fiona, Adam, Matthew, Adamali, Huzaifa, Adams, Carol, Adams, Kate, Adams, Richard, Adams, Tim, Adamus, Malgorzata, Adcock, Kirsty, Adebiyi, Aderonke, Adegoke, Ken, Adell, Vicki, Adeni, Aldrin, Adenwalla, Sherna, Adesemoye, Oluwasegun A, Adewunmi, Emmanuel O, Adeyemi, Joyce, Adeyeye, Elizabeth, Adkins, Gabrielle, Adnan, Adnan, Aeron-Thomas, John, Afari, Lynn, Affleck, Debbie, Afnan, Carmel, Afolabi, Deborah, Afridi, Muhammad, Agbeko, Rachel, Agbo, Chris, Aggarwal, Sunil, Aghababaie, Arameh, Agwada-Akeru, Judith, Agyapong, Kwame A, Ahamed Sadiq, Shafana, Ahammed Nazeer, Mohamed H, Ah-Chuen, Jonathan, Ahmad, Mahin, Ahmed, Ashar, Ahmed, Bilal, Ahmed, Forizuddin, Ahmed, Iram, Ahmed, Irshad, Ahmed, Liban, Ahmed, Maria C, Ahmed, Muhammad S, Ahmed, Naseer, Ahmed, Nausheen, Ahmed, Osama, Ahmed, Rajia A, Ahmed, Rizwan, Ahmed, Saif, Ahmed, Sammiya, Ahmed, Sara, Ahmed, Syed H, Ahmed Ali, Roa, Ahmer, Sana, Ail, Dhiraj, Ainsley, Adam, Ainsworth, Mark, Aissa, Myriam, Aitchson, Lucy, Aitken, Lindianne, Ajay, Bini, Ajibode, Abdulakeem, Ajmi, Ayesha, Akhtar, Muhammad N, Akhtar, Nasim, Akili, Suha, Akindolie, Oludoyinsola, Akinfenwa, Yinka, Akinkugbe, Olugbenga, Akinpelu, Ibrahim, Akudo, Umeh, Al Balushi, Asma, Al Dakhola, Majd, Aladangady, Narendra, Alam, Sajid, Al-Asadi, Abbas, Alatzoglou, Kyriaki, Albon, Lorraine, Alcorn, Stephen, 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Victoria, Amsha, Khaled, Anand, Atul, Anandappa, Samantha, Anderson, Julie, Anderson, Laura, Anderson, Michelle, Anderson, Nicola, Anderson, Rachel, Anderson, Rory, Andreou, Prematie, Andrews, Angela, Andrews, Jill, Aneke, Kanayochukwu, Ang, Andrew, Ang, Wan Wei, Angel, Tammy, Angelini, Paola, Anguvaa, Lazarus, Anichtchik, Oleg, Anim-Somuah, Millicent, Aniruddhan, Krishnan, Anthony, Alpha, Anthony-Pillai, Aaron, Antill, Philip, Antonina, Zhelyazkova, Anu, Varghese, Anwar, Muhammad, Apostolopoulos, Aristeidis, Appleby, Sarah, Appleyard, Diane, Araba, Bianca, Aramburo, Angela, Archer, Ann, Archer, Denise, Archer, Simon, Ardley, Christian, Arias, Ana-Maria, Arimoto, Ryoki, Arkley, Charlotte, Armah, Charlotte, Armata, Ilianna, Armitage, Adam, Armstrong, Ceri, Armstrong, Maureen, Armstrong, Sonia, Armtrong, Philippa, Arndt, Heike, Arnison-Newgass, Clare, Arnold, David, Arnold, Rachael, Arora, Dhawal, Arora, Pardeep, Arora, Rishi, Arter, Arslam, Arunachalam, Ganesh, Arya, Rita, Asam, Salma, Asandei, Denisa, Asghar, Adeeba, Ashbrook-Raby, Catherine, Ashby, Helen, Ashcroft, Jan, Ashcroft, John, Ashfaq, Ayesha, Ashish, Abdul, Ashman-Flavell, Sally, Ashok, Sundar, Ashraf, Muhammad Z, Ashraf, Saima, Ashraq, Mohammad B, Ashton, Deborah, Ashton, Susan, Ashworth, Andrew, Ashworth, Rebecca, Asogan, Harshini, Asplin, Julia, Asrar, Atif, Assaf, Omar, Astin-Chamberlain, Raine, Athorne, Deborah, Atkins, Christopher, Atkins, Stacey, Atkinson, John, Atkinson, Vicki, Attiq, Ahmed, Aubrey, Paula, August, Suzannah, Aung, Aye CT, Aung, Hnin, Aung, Kyaw Thu, Aung, Nini, Aung, Zaw Myo, Austin, Emily, Austin, Karen, Avery, Miriam, Avis, Joanne, Avram, Cristina, Avram, Paula, Awadzi, Gabriel, Aya, Aszad, Ayaz, Eman, Ayers, Amanda, Ayra, Vivek, Azam, Jawwad, Azharuddin, Mohammed, Aziz, Ghazala, Azman Shah, Ashaari, Azzopardi, Giada, Azzoug, Hocine, Babajan, Nasaruilla, Babatunde, Fiyinfoluwa, Babi, Melvin, Babiker, Babiker, Babington, Gayna, Babirecki, Matthew, Babs-Osibodu, Adetona O, Bacon, Gina, Bacon, Jenny, Badal, Bibi, Badhan, Gurpreet R, Badhrinarayanan, Shreya, Bae, Joseph, Baggaley, Alice, Baggott, Amy, Bagley, Graham, Bagmane, Dinesh, Bahadori, Kasra, Baijiu, Gayathri, Bailey, Charles, Bailey, Julie, Bailey, Katie, Bailey, Lindsey, Bailey, Liz, Bailey, Morgan, Bailey, Peter, Baillie, Hamish, Baillie, Kenneth, Bain, Jennifer, Bain, Karen, Bainton, Becky, Baird, David, Baird, Yolanda, Bajandouh, Aiysha, Baker, Evelyn, Baker, Johanne, Baker, Kenneth, Baker, Pearl, Bakere, Hugh, Bakerly, Nawar, Baker-Moffatt, Michelle, Bakoulas, Panos, Bal, Abhijit, Balachandran, Niranjan, Balagosa, Irvin, Balan, Andrea, Balaskas, Theodosios, Balasubramaniam, Madhu, Balcombe, Alison, Baldwick, Cheryl, Baldwin, Alexander, Baldwin, Ashley, Baldwin, Danielle, Baldwin, Lisa, Baldwin-Jones, Rebekah, Balfour, James, Ball, Ceri, Balmforth, Craig, Bambridge, Gabby, Bamford, Alasdair, Bamford, Amy, Bamford, Peter, Bamgboye, Adefunke, Bamunuarachchi, Kasun, Bancroft, Elizabeth, Bancroft, 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Archana, Basker, Betsy, Basoglu, Ayten, Bassaly, Amira, Bassett, G, Bassoy, Bengisu, Basumatary, Anupam, Bataineh, Adam, Batalla, Freddie, Bate, Tristan, Bateman, Harry John, Bateman, Kathryn, Bateman, Vhairi, Bates, Eleanor, Bates, Hayley, Bates, Michelle, Batha, Rizvan, Batham, Sally, Batista, Ana, Batla, Amit, Batra, Dushyant, Batty, Harry, Batty, Thomas, Baum, Miranda, Bautista, Carina, Bawani, Fatima S, Bax, Simon, Baxter, Matt, Baxter, Nicola, Bayes, Hannah, Bazari, Farid, Bazaz, Rohit, Bazli, Ahmad, Beacham, Laura, Beadle, Hannah, Beadles, Wendy, Beak, Philip, Beale, Andy, Beardsal, Kathy, Bearpark, Jack, Beaumont, Karen, Beaumont, Matthew, Beaumont-Jewell, Dawn, Beaver, Theresa, Beavis, Sarah, Beazley, Christy, Beck, Sarah, Beckett, Virginia, Beckitt, Rosie, Beddall, Heidi, Beddows, Seonaid, Beeby, Deborah, Beecroft, Michelle, Beer, Sally, Beety, Jane, Bega, Gabriela, Begg, Alison, Begg, Susan, Beghini, Sara, Begum, Ayesha, Begum, Safia, Behan, Teresa, Behrouzi, Roya, Beishon, Jon, Beith, Claire, Belcher, James, Belfield, Holly, Belfield, Katherine, Belgaumkar, Ajay, Bell, Dina, Bell, Gareth, Bell, Gillian, Bell, Lauren, Bell, Louise, Bell, Nicholas, Bell, Stephanie, Bell, Jennifer L, Bellamy, Mary, Bellini, Arianna, Bellis, Amanda, Bellis, Fionn, Bendall, Lesley, Benesh, Naveena, Benetti, Nicola, Benham, Leonie, Benison-Horner, Guy, Bennett, Ann, Bennett, Caroline, Bennett, Gillian, Bennett, Kristopher, Bennett, Lorraine, Bennett, Sara, Benson, Vivienne, Bentley, Andrew, Benton, Ian, Beranova, Eva, Beresford, Matthew, Bergin, Colin, Bergstrom, Malin, Bernatoniene, Jolanta, Berriman, Thomas, Berry, Zoe, Best, Kimberley, Beuvink, Yvonne, Bevan, Emily, Bevins, Sarah, Bewick, Tom, Bexhell, Helen, Bexley, Andrew, Beyatli, Sonay, Beynon, Fenella, Bhadi, Arjun, Bhagani, Sanjay, Bhagat, Shweta, Bhakta, Shiv, Bhalla, Rekha, Bhalme, Mahesh, Bhandal, Khushpreet, Bhandal, Kulbinder, Bhanot, Ravina, Bhat, Prashanth, Bhatia, Nikhil, Bhatnagar, Rahul, Bhayani, Janki, Bhojwani, Deepika, Bhuiyan, Salimuzzaman, Bibby, Anna, Bibi, Naheeda, Bibi, Salma, Bicanic, Tihana, Bigg, Julie, Biggs, Sarah, Biju, Alphonsa, Bikov, Andras, Billingham, Sophie, Billings, Jessica, Binns, Alice, Bintcliffe, Oliver, Birch, Catherine, Birch, Janine, Birch, Jenny, Birchall, Katherine, Bird, Sam, Bird, Sumedha, Birt, Mark, Bishop, Kilanalei, Bishop, Linda, Bishop, Lisa, Biswas, Nibedan, Biuk, Sahar, Blachford, Karen, Black, Ethel, Black, Helen, Black, Karen, Black, Mairead, Black, Polly, Black, Sabrina, Blackledge, Bethan, Blackler, Joanne, Blackley, Samantha, Blackman, Helen, Blackstock, Caroline, Blakemore, Francesca, Blamey, Helen, Blane, Sujata, Blankley, Simon, Blaxill, Parry, Blazeby, Jane, Blencowe, Natalie, Bloom, Ben, Bloss, Angela, Bloxham, Hannah, Blundell, Louise, Blunden, Susara, Blunt, Mark, Blyth, Ian, Blyth, Kevin, Blythe, Andrew, Bobruk, Karen, Bodalia, Pritesh, Bodasing, Neena, Boehmer, Gabriele, Boffito, Marta, Bokhandi, Sumit, Bokhar, Maria, Bokhari, Saba, Bokhari, Sakina, Bokhari, Syed Owais, Boles, Ambrose, Bolton, Matthew, Bond, Helena, Bond, Stuart, Bond, Thomas, Bone, Alice, Boniface, Georgia, Bonney, Lizzy, Borbone, Joanne, Borg, Stephanie, Borra, Catherine, Bosompem, Samuel, Botfield, Liam, Bottrill, Fiona, Bouattia, Hannah, Bough, Laura, Boughton, Hayley, Boult, Zoe, Bourke, Miriam, Bourne, Karen, Bourne, Michelle, Bousefield, Rachel, Boustred, Lucy, Bowes, Alexandra, Bowes, Amy, Bowker, Philip, Bowman, Louise, Bowman, Simon, Bowring, Angie, Boyapati, Geetha, Boyd, Jenny, Boyd, Laura, Boyle, Namoi, Boyle, Pauline, Boyle, Rosalind, Boyles, Louise, Brace, Leanna, Bradder, Jodie, Bradley, Clare J, Bradley, Pamela, Bradley, Patrick, Bradley-Potts, Joanne, Bradshaw, Lynne, Bradshaw, Zena, Brady, Rebecca, Brady, Shirin, Branch, Marie, Brandl-Salutz, Emily, Branfield, Christina, Brannigan, Jamie, Brassington, Louise, Bray, Fiona, Bray, Nancy, Brazil, Manny, Brear, Lucy, Brear, Tracy, Brearey, Stephen, Brend, Morwenna, Brereton, Andrew, Brewer, Chris, Bridgwood, Gavin, Brigham, Sara, Bright, John, Brightling, Christopher, Brinkworth, Elaine, Brittain-Long, Robin, Britten, Vianne, Broad, Lauren, Broad, Sarah, Broadhurst, Rosie, Broadley, Andrew, Broadway, Marie, Brockelsby, Christopher, Brocken, Megan, Brockley, Tomos, Brogan, Fiona, Brokke, Felicity, Brolly, Jacob, Bromley, David, Brooke-Ball, Hannah, Brooker, Verity, Brookes, Matthew, Brooks, Alison, Brooks, Kate, Brooks, Nicole, Brooks, Rachel, Brooks, Sophie, Broomhead, Natalie, Broughton, Chloe, Broughton, Nathaniel, Brouns, Matt, Brown, Alison, Brown, Carly, Brown, Catrin, Brown, Ellen, Brown, Heather, Brown, Janet, Brown, Louise, Brown, Niall, Brown, Pauline, Brown, Richard, Brown, Robert, Brown, Steven, Brown, Tom, Browne, Charlotte, Browne, Duncan, Browne, Rachel, Brownlee, Stephen, Bruce, David, Bruce, Johanna, Bruce, Michelle, Brudlo, Wojciech, Brunskill, Nigel, Brunton, Luke, Brunton, Margaret, Bryant, Jade, Bryce, Mark, Buch, Maya, Buchanan, Ruaridh, Buck, Amanda, Buckingham, Elizabeth, Buckley, Laura, Buckley, Philip, Buckley, Sarah, Buckman, Carol, Bugg, George, Bujazia, Ramadan, Bukhari, Shanzay, Bulbulia, Richard, Bull, Alex, Bull, Damian, Bull, Rhian, Bull, Thomas, Bullard, Sam, Bulteel, Naomi, Bunclark, Katherine, Bungue-Tuble, Roneleeh, Burchett, Caroline, Burden, Christy, Burden, Thomas G, Burge, Sarah, Burgess, Mika, Burgess, Sophia, Burke, Emma, Burnard, Sara, Burnett, Caroline, Burns, Amy, Burns, Collette, Burns, James, Burns, Karen, Burrage, Daniel, Burrows, Kate, Burston, Claire, Burton, Ben, Burton, Fiona, Butchart, Angus, Butler, Aaron, Butler, Jo, Butler, Joanne, Butler, Joshua, Butler, Peter, Butler, Susan, Butt, Al-Tahoor, Butterworth, Caryl, Butterworth-Cowin, Nicola, Buttery, Robert, Button, Heather, Buttress, Daniel, Byrne, Jane, Byrne, Wendy, Byrne-Watts, Victoria, Cade, Ruth, Cairney, Donna, Calderwood, Claire, Calderwood, James, Calisti, Giorgio, Callaghan, Debbie, Callaghan, Jennifer, Callens, Claire, Calver, Caroline, Cambell-Kelly, Melissa, Camburn, Tracey, Cameron, David R, Cameron, Eleanor, Cameron, Fraser, Cameron, Sheena, Camm, Christian, Cammack, Renee FD, Campbell, Alison, Campbell, Amy, Campbell, Barbara, Campbell, Bridget, Campbell, Debbie, Campbell, Helen, Campbell, Hilary, Campbell, Jonathan, Campbell, Mark, Campbell, Robyn, Campbell, Wynny, Campbell Hewson, Quentin, Camrasa, Laura, Camsooksai, Julie, Candido, Shaula M, Caneja, Cielito, Cann, Johnathon, Cannan, Ruby, Cannon, Emma, Cannon, Michael, Cannon, Petra, Cannons, Vivienne, Cantliff, Jane, Caplin, Ben, Capp, Angelika, Capstick, Thomas, Carley, Simon, Carlin, Tammy, Carmichael, Samantha, Carmody, Margaret, Carnahan, Mandy, Caroline, Charlotte, Carr, Patrick, Carr, Sharon, Carrasco, Anna, Carrington, Zoe, Carter, Jonathan, Carter, Paul, Carter, Penny, Cartwright, Douglas, Carty, Claire, Carungcong, Jaime, Carvelli, Paula, Cashell, Aisling, Cassimon, Barbara, Castiello, Teresa, Castle, Gail, Caswell, Melanie, Catana, Ana Maria, Cate, Heidi, Cathcart, Susanne, Cathie, Katrina, Catley, Christine, Catlow, Laura, Causer, Kerry, Cave, Luke, Cawa, Frianne, Cawley, Kathryn, Cawley, Philippa, Caws, Chloe, Cendl, Hankins, Cernova, Jeva, Cetti, Ed, Chabane, Stephanie, Chablani, Manish, Chabo, Cathleen, Chadwick, David, Chadwick, Julie, Chadwick, Robert, Chakkarapani, Ela, Chakraborty, Arup, Chakraborty, Mallinath, Chakravorty, Mollika, Chalmers, James, Chamberlain, Georgina, Chamberlain, Sarah, Chambers, Carol, Chambers, Emma, Chambers, Jonathan, Chambers, Lucy, Chambers, Naomi, Champanerkar, Shreekant, Chan, Carmen, Chan, Cheuk, Chan, Evelyn, Chan, Kimberley, Chan, Ping, Chan, Rebekah (Pui-Ching), Chan, Xin H, Chandler, Chris, Chandler, Kim J, Chandler, Zoe, Chandrasekaran, Badrinathan, Chaplin, Josephine, Chapman, Graeme, Chapman, John, Chapman, Katie, Chapman, Laura, Chapman, Lianne, Chapman, Polly, Chapman, Timothy, Chappell, Lucy, Charalambou, Amanda, Charles, Bethan, Charlton, Dianne, Chatar, Kevin, Chatha, Calvin, Chaturvedi, Priyanka, Chaudhary, Muhammad YN, Chaudhry, Iram, Chaudhry, Zain, Chaudhuri, Nazia, Chaudhury, Muhammad, Chauhan, Anoop, Chauhan, Milan, Chauhan, Ruchi S, Chavasse, Nicola, Cheaveau, James, Cheeseman, Michelle, Chen, Fang, Chen, Hui Min, Chen, Terence, Cheng, Lok Y, Cheng, Zhihang, Chengappa, Ashok, Chenoweth, Helen, Cheong, Chun H, Cherian, Shiney, Cheshire, Helen, Chessell, Sarah, Cheung, Chee Kay, Cheung, Elaine, Cheyne, Claire, Chhabra, Swati, Chiang, Eric, Chiapparino, Angela, Chicano, Rosavic, Chilcott, Sam, Chimbo, Phillipa, Chin, KokWai, Chin, Wen Jie, Chingale, Amol, Chisem, Heather, Chisnall, Ben, Chita, Sunder, Chitalia, Nihil, Chitsenga, Chipo, Chiu, Matthew, Chivima, Brenda, Choi, Soha, Choon Kon Yune, Willy, Choudhary, Khayzer, Choudhary, Vandana, Chow, Gary, Chowdhury, Muhibbur, Christides, Alexander, Christie, Alex, Christmas, Daniel, Christopherson, Thereza, Christy, Mark, Chrysostomou, Paris, Chua, Yunli, Chudgar, Dip, Chudleigh, Richard, Chukkambotla, Srikanth, Chukwulobelu, Izu, Chukwunonyerem, Favour, Chung, Chi Y, Chung, Jonathan, Church, Elaine, Church, Sara R, Churchill, David, Cicconi, Paola, Cipinova, Zdenka, Cipriano, Bessie, Clamp, Sarah, Clapham, Melanie, Clare, Edel, Clare, Sarbjit, Clark, Andrew, Clark, Charlotte, Clark, Diane, Clark, Felicity, Clark, Gabrielle, Clark, James, Clark, Katherine, Clark, Lucy, Clark, Matthew, Clark, Patricia, Clark, Richard, Clark, Thomas, Clark, Zoe, Clarke, Andrea, Clarke, Paul, Clarke, Robert, Clarke, Roseanne, Clarke, Samantha, Clarke, Sheron, Claxton, Alleyna, Clayton, Elizabeth, Clayton, Olivia, Clayton-Smith, Jill, Cleaver, Chris, Clemens, Jayne, Clemente de la Torre, Carlota, Clements, Suzanne, Clifford, Sarah, Clive, Amelia, Clouston, Jonathan, Clueit, Samantha, Clyne, Andrea, Coakley, Peter GL, Cobain, Kathryn, Coburn, Susan, Cochrane, Alexandra, Cochrane, Patricia, Cockburn, Samantha, Cockerill, Helen, Cocks, Shirley, Codd, Rhodri, Codling, Rachel, Coe, Adam, Coetzee, Samantha, Coey, David, Cofie, Paul F, Cohen, Danielle, Cohen, Jonathan, Cohen, Oliver, Cohn, Mike, Coke, Louise, Colbeck, Nicholas, Colbert, Roghan, Cole, Esther, Cole, Jade, Cole, Joby, Cole, Nicholas, Coleman, Garry, Coleman, Matt, Coles, Holly, Colley, Julie, Collier, Dawn, Collier, Heather, Collini, Paul, Collins, Emma, Collins, Jaimie, Collins, Joanne, Collins, Nicola, Collins, Sally, Collins, Vicky, Collinson, Andrew, Collinson, Jennifer, Colmar, Madeleine, Colton, Hayley E, Colton, James, Colville, Katie, Colvin, Carolyn, Combes, Edward, Comer, David, Concannon, Dónal, Condliffe, Robin, Connell, Lynne, Connell, Natalie, Connolly, Gavin, Connor, Emma, Conroy, Antonia, Conteh, Veronica, Convery, Rory, Conway, Grainne, Conway, Rhiannon, Conyngham, Jo-Anna, Cook, Eloise, Cook, Gemma, Cook, Helen, Cooke, Graham, Cooke, Katrina, Coombs, Catherine, Cooper, Chris, Cooper, Jamie, Cooper, Joshua, Cooper, Lauren, Cooper, Rowena, Cooper, Sophie, Cope, Thomas, Corbett, Carolyn, Corcoran, John, Cordle, Jessica, Corfield, Alasdair, Corless, John, Corlett, Alison, Corlett, Pamela, Cornwell, Michael, Corogeanu, Diana, Corrigan, Ruth, Corser, Rita, Cort, Jon, Cosgrove, Denise, Costa, Patricia, Coston, Charlie, Cotgrove, Susannah, Coton, Zoe, Cottam, Lisa-Jayne, Cotter, Rhiannon, Cotterill, Donna, Cotton, Caroline, Coulson, James, Counter, David, Coupland, Cherry, Courtney, Ellie, Courtney, Julia, Cowan, Elena, Cowen, Louise, Cowman, Steve, Cowton, Amanda, Cox, Ellie, Cox, Giles, Cox, Karina, Cox, Rebecca, Coy, Karen, Craig, Victoria, Cramp, Matthew, Crawford, Emma, Crawford, Isobel, Crawshaw, Sarah, Creagh-Brown, Ben, Creamer, Andrew, Creber, Peter, Cremona, Joanne, Cresswell, Janet, Cribb, Mark, Crichton, Charles, Crilly, Declan, Crisp, Lauren, Crisp, Nikki, Crocombe, Dominic, Croft, Maria, Crooks, Jennifer, Crosby, Harriet, Cross, Tim, Crotty, Stephen, Crouch, Susan, Crow, Madeleine, Crowder, Rory, Crowe, Becky, Croysdill, Rebecca, Cruickshank, Irena, Cruise, James, Cruz, Carina, Cruz Cervera, Trino, Cryans, Dominic, Cui, Guanguo, Cummings-Fosong, Gillian, Cunliffe, Victoria, Cunningham, Caroline, Cunningham, Mishell, Cunningham, Neil, Cunningham, Nicola, Cupitt, Jason, Curgenven, Hollie, Curnow, Gerens, Curran, Simon, Currie, Scarlett, Curtin, Michelle, Curtis, Jonathan, Curtis, Katrina, Curtis, Olivia, Cuthbertson, Rebecca, Cutler, Sean, Czylok, Patrycja, da Rocha, Joana, Dabbagh, Sura, Daggett, Helen, Daglish, Jacqui, Dale, Anne, Dale, Katie, Dale, Michaela, Dale, Sam, Dales, Jolyon, Dalgleish, Helen, Dalton, Dermot, Daly, Aoife, Dandavate, Vaishnavi, Danga, Akila, Daniel, Amelia, Daniel, Priya, Daniels, Allison, Danso-Bamfo, Sandra, Darbyshire, Alex, Darbyshire, Janet, Dark, Paul, Darlington, Kate, Darton, Tom, Darylile, Guledew, Das, Manjusha, Das, Sukamal, Daschel, Martin, Dasgin, Joanne, Datta, Dibyendu, Daunt, Anna, Davey, Mark, Davey, Miriam, David, Anette, David, Mini, David, Sarah, Davidson, Alexander, Davidson, Laura, Davidson, Neil, Davidson, Richard, Davies, Albert, Davies, Amanda, Davies, Carolyn, Davies, Catrin, Davies, Drew, Davies, Elaine, Davies, Ffyon, Davies, Helen, Davies, Jim, Davies, Karen, Davies, Kelly, Davies, Kim, Davies, Louisa, Davies, Matthew, Davies, Michelle, Davies, Owen, Davies, Patrick, Davies, Rachel, Davies, Rhys, Davies, Ruth, Davies, Sarah, Davies, Simon, Davies, Wendy, Davis, Gwyneth, Davis, Illinos, Davis, Peter, Davison, Alexander, Dawe, Christine, Dawson, Danielle, Dawson, Elizabeth, Dawson, Joy, Dawson, Tom, Daxter, Andrew, Day, Andrew, Day, Jacob, Day, Jeremy, De, Parijat, de Berker, Henry, de Fonseka, Duneesha, de Freitas, Toni, de Santana Miranda, Frederico, de Sausmarez, Eleanor, de Silva, Shanika, de Silva, Thushan, de Souza, James, de Soyza, Anthony, de Vere, Natasha, de Vos, Johannes, Deacon, Bethan, Dealing, Sharon, Dean, Anna, Dean, Julie, Dean, Katrina, Deane, Jill, Dear, James, Dearden, Effie, Deas, Catherine, Deelchand, Vashist, Deeley, Matthew, Deery, Joanne, Defever, Emmanuel, Del Forno, Manuela, Dela Rosa, Arnold, Dell, Amanda, DeLuna, Marilyn, Demetriou, Carrie, DeMets, David, Democratis, Jane, Denham, Jacqueline, Denis, Emmanuelle, Denmade, Craig, Dent, Kathy, Dent, Martin, Denton, Elise, Denwood, Tom, Deole, Nishigandh, Depala, Darshita, Dermody, Susan, Desai, Amisha, Desai, Purav, Deshpande, Sanjeev, Deshpande, Vai, Devkota, Sirjana, Dey, Prakash, Dey, Vishal, Deylami, Rogin, Dhaliwal, Gurlove K, Dhaliwal, Kevin, Dhani, Sundip, Dhanoa, Amandeep, Dhar, Mili, Dhariwal, Sukhjit, Dhasmana, Devesh, Dhillon, Ekanjali, Dhillon, Reiss, Diaz-Pratt, Kayleigh, Dicks, Pamela, Dickson, Matthew, Dillane, Sean, Diment, Sarah, Dimitri, Paul, Dipper, Alex, Dirmantaite, Laura, Ditchfield, Lisa, Diver, Sarah, Divikar, Nandita, Diwakar, Lavanya, Diwan, Masroor, Dixon, Caroline, Dixon, Catherine, Dlouhy, Petr, Dmitri, Paul, Dobranszky Oroian, Marinela, Dobson, Charlotte, Dobson, Lee, Docherty, Marie, Dockery, Morven, Docks, Emma, Dodd, James, Dodds, Jackie, Dodds, Rebecca, Dodds, Steve, Dogra, Richi, Doherty, Erin, Doherty, Warren, Doi, Yumiko, Doig, Iain, Dolan, Daniel, Dolman, Mark, Dolman, Rozzie, Donald, Lisa, Donaldson, Callum, Donaldson, Denise, Donaldson, Kate, Donlon, Sinead, Donnachie, Joanne, Donnelly, Christopher, Donnelly, Eilish, Dooks, Emma, Dooley, Andrew, Dorey, Kane, Dorgan, Sharon, Dosanjh, Davinder, Dospinescu, Paula, Dougherty, Andrew, Douglas, Katie, Dowden, Lucy, Dower, Michelle, Dowling, Sud, Downe, Hayley, Downer, Nicola, Downes, Charlotte, Downes, Rob, Downes, Thomas, Downey, Damian, Downs, Louise, Dowson, Simon, Dragan, Cornel, Dragos, Cristina, Drake, Chelsea, Drew, Victoria, Drewett, Olivia, Driscoll, Celine, Drogan, Helena, Druyeh, Ronald, Drysdale, Simon, Dube, Hazel, Dube, Judith, Duberley, Stephen, Dubrey, Simon, Duckitt, Roger, Duckles-Leech, Hayley, Duff, Nicola, Duffy, Helen, Dufour, Lionel, Duggan, Annette, Dugh, Parveen, Duignan, Janice, Dummer, Simon, Duncan, Andrew, Duncan, Barrie, Duncan, Christopher, Duncan, Fullerton, Dunn, Alessia, Dunn, Damian, Dunn, Laura, Dunne, Karen, Dunning, Fiona, Dunphy, Aidan, Duraiswamy, Venkat, Duran, Beatriz, DuRand, Ingrid, Durie, Alison, Durie, Emily, Durrans, Laura, Durrington, Hannah, Dwarakanath, Akshay, Dwarakanath, Laasya, Dwyer, Ellen, Dyball, Claudia, Dymond, Harvey, Dymond, Tom, Eades, Chris, Earwaker, Melissa, Easom, Nicholas, East, Clare, Easton, Jack, Eatough, Ruth, Ebigbola, Oluwadamilola, Ebon, Martin, Eccles, Sinan, Eddings, Chloe, Eddleston, Michael, Edgar, Maureen, Edgerley, Katharine, Edmondson, Mary, Edmunds, Tracy, Edwards, Alexandra, Edwards, Andrea, Edwards, Catherine, Edwards, Joy, Edwards, Kennedy, Edwards, Mandy, Edwards, Steven, Eedle, Jenny, Egginton, Dawn, Eisen, Sarah, Ekeowa, Ugochukwu, Ekoi, Mohamed, Ekunola, Ayomide, El Bouzidi, Kate, Elden, Ashley, Elder, Jennifer, Eldew, Haifa, Eleanor, Diana, Elfadil, Maysoon, Elfar, Eman, Elgamal, Mayy M, Elgohary, Amr, Elia, Stellios, Elias, Jennifer, Elias, Tania, Elkaram, Nadia, Elkhawad, Amin, Elkins, Andrew V, Ellam, Julie, Ellard, Nikki, Ellerton, Laura Nicola, Elliott, Amy, Elliott, Fiona, Elliott, Kerry, Elliott, Valmai, Ellis, Annie, Ellis, Hayley, Ellis, Kaytie, Ellis, Tak-Yan, Ellis, Yvette, Elmahdi, Rahma, Elmahi, Einas, Elneima, Omer, Elokl, Mohamed, Elradi, Ahmed, Elsaadany, Mohamed, El-Sayeh, Sally, El-Sbahi, Hana, Elsefi, Tarek, El-Shakankery, Karim, Elyoussfi, Sarah, Emberson, Jonathan, Emberton, John, Emmanuel, Julian, Emmerson, Ingrid, Emmett, Charis, Emms, Michael, Emonts, Marieke, Engden, Angila, English, Katy, Entwistle, Nicola, Enyi, Hene, Erin Jones, Ruth, Ermenyi, Agota, Esmail, Hanif, Eusuf, Ajmal, Evans, Brynach, Evans, Chris, Evans, Debra, Evans, Gail, Evans, Gareth, Evans, Jennifer, Evans, Lynn, Evans, Melanie, Evans, Mim, Evans, Morgan, Evans, Ranoromanana, Evans, Teriann, Evans, Terry J, Everden, Caroline, Evison, Lynsey, Faccenda, Jacqueline, Fahel, Leila, Fahmay, Youstina, Fairbairn, Sara, Fairclough, Andy, Fairlie, Louise, Fajardo, Anne, Falconer, Euan, Fallon, John, Faluyi, David, Farah, Qayyum, Fard, Novin, Farg, Amr, Farmer, Adam, Farmer, Katie, Farmery, Toni, Farnworth, Frances, Farnworth, Samantha, Farook, Faiyaz, Farooq, Hadia, Farooq, Sidrah, Farquhar, Fiona, Farrell, Aaron, Farrell, Barbara, Farthing, James, Farzana, Syeda, Fasina, Rahmatu, Fatemi, Azam, Fatemi, Mina, Fatimah, Nibah, Faust, Saul N, Fawke, Joe, Fawohunre, Sinmidele, Feben, Alex, Fedel, Federico, Fegan, Christopher, Felongco, Mae, Felton, Lynsey, Felton, Tim, Fenlon, Kate, Fenn, Andrea, Fenner, Isabelle, Fenton, Ciara, Fenton, Melisa, Ferguson, Cameron, Ferguson, Jenny, Ferguson, Kathryn, Ferguson, Katie, Ferguson, Lisa, Ferguson, Susan, Ferguson, Susie, Ferguson, Victoria, Fernandes, Denzil, Fernandez, Candida, Fernandez, Eduardo, Fernandez Lopez, Sonia, Feroz, Ahmed, Ferranti, Pietro, Ferrari, Thais, Ferreira-De Almeida, Catarina, Ferrera, Alexandra, Ferriman, Emma, Fethers, Nicholas, Field, Ben, Field, Janet, Fielding, Andra, Fielding, Julie, Fielding, Sarah, Fikree, Asma, Filson, Sarah Ann, Finch, Joanne, Finch, Laurie, Fineman, Natalie, Finn, Adam, Finn, Joanne, Fiouni, Sofia, Fiquet, Jo, Fisher, James, Fisher, Neil, Fishman, Daniel, Fishwick, Krystofer, Fisk, Marie, Flaherty, Jan, Flanagan, Michael, Flanders, Charles, Fleming, Julie, Fleming, Lucy, Fleming, Paul, Flesher, William, Fletcher, Alison, Fletcher, Lucy, Fletcher, Sophie, Flood, Christopher, Flor, Jonathan, Florence, Vincent, Floyd, Sharon, Fofana, Adama, Fogarty, Georgina, Folkes, Linda, Foo, Aiwyne, Foot, Andrew, Foot, Jayne, Forbes, Jane, Forcer, Kathryn, Ford, Jamie, Foreman, Jennifer, Fornolles, Caroline, Forrest, Adam, Forsey, Ellie, Forshall, Thomas, Forster, Elliot, Forton, Julian, Foster, Emily, Foster, Joseph, Foster, Rachel A, Foster, Tracy, Foulds, Angela, Foulds, Ian, Fowe, Folakemi, Fowler, Emily, Fowler, Robert, Fowler, Stephen, Fox, Caroline, Fox, Claire, Fox, Heather, Fox, Jonathan, Fox, Lauren, Fox, Natalie, Fox, Simon, Foxton, Sarah-Jane, Frake, Rebecca, Francioni, Alex, Francis, Olesya, Francis, Rebecca, Francis, Sarah, Francis-Bacon, Theodora, Francois, Victoria, Frayling, Sharon, Fredlund, Martyn, Freeborn, Michael, Freeman, Carol, Freeman, Elaine, Freeman, Hannah, Freeman, Nicola, Freer, Clare, French, Eleanor, Fries, Anastasia, Frise, Matthew, Fromson, Renate, Froneman, Claire, Frost, John, Frost, Victoria, Frowd, Rachel, Fryatt, Arun, Fuller, Bridget, Fuller, Elizabeth, Fuller, Tracy, Fullerton, Duncan, Funnell, Sarah, Furness, John, Furreed, Hassina, Gaba, Waqas, Gabbitas, Elizabeth, Gabriel, Claire, Gahir, Joshua, Gajewska-Knapik, Katarzyna, Gale, Christopher, Gale, Hugo, Gali, Swetha, Gallagher, Bernadette, Gallagher, Edith, Gallagher, Jude, Gallagher, William, Galloway, Catherine, Galloway, Emma, Galloway, Jacqui, Galloway, James, Gamble, Laura, Gamble, Liz, Gammon, Brian, Ganapathi, Jaikumar, Ganapathy, Ramesh, Gandhi, Kaminiben, Gandhi, Sarah, Ganesh, Usha, Gani, Abrar, Garcia Deniz, Iris, Gardener, Antoni D, Gardiner, Danielle, Gardiner, Emma, Gardiner, Kirsty, Gardiner, Siobhan, Gardiner-Hill, Caroline, Gardner, Jonathan, Garfield, Mark, Garg, Atul, Garlick, Nathan, Garner, Lucie, Garner, Zoe, Garr, Rosaline, Garton, Mark, Garty, Florence, Gascoyne, Rachel, Gashau, Hyeriju, Gatenby, Aoife, Gaughan, Erin, Gaurav, Alok, Gavrila, Mariana, Gaylard, Jane, Gaywood, Emma, Geddie, Catherine, Gee, Sarah, Genato, Gemma, Gent, Neil, Gent, Susan, Geoghegan, Natalie, George, Nithin, George, Sam, George, Tina, Georges, Simon, Georgiou, Domonique, Gerdes, Leigh, Germain, Louise, Gerrish, Helen, Getachew, Abel, Ghanayem, Hisham, Ghazanfar, Auns, Gherman, Anca, Ghosh, Alison, Ghosh, Arjun, Ghosh, Justin, Ghosh, Sudhamay, Giannopoulou, Sarra, Gibani, Malick, Gibbison, Ben, Gibbons, Kerry, Gibson, Bethan, Gibson, Henry, Gibson, Kimberley, Gibson, Kirsty, Gibson, Sian, Gilbert, Cat, Gilbert, Jeanette, Gilbert, Kayleigh, Giles, Benjamin, Gill, Mandy, Gill, Lynne, Gillen, Paul, Gillesen, Annelies, Gilliland, Deborah, Gillott, Robert, Gilmore, Jemma, Gilmour, Danielle, Gilmour, Kate, Giokanini-Royal, Theodora, Gipson, Anna, Girling, Joanna, Gisby, Rhian, Gkioni, Angelena, Gkrania-Klotsas, Effrossyni, Gladwell, Amy, Glanville, James, Glasgow, Susannah, Glass, Jon, Glass, Lynn, Gledhill, Lisa, Glennon, Ana, Glover, John, Glover, Kyle, Glover Bengtsson, Jan, Gnanalingam, Chevanthy, Goddard, Julie, Goddard, Wendy, Godden, Emily, Godden, Jo, Godson, Emma, Goh, Aiky, Gohil, Sunita, Goiriz, Rebeca, Gokaraju, Sriya, Goldacre, Raphael, Goldsmith, Arthur, Goldsmith, Portia, Gomersall, Darren, Gomez, Lucia, Gomez-Marcos, Raquel, Gondal, Ali, Goodall, Jack, Goodenough, Bob, Goodwin, Camelia, Goodwin, Elizabeth, Goodwin, Jayne, Goodyear, Paula, Gooentilleke, Rajiv, Goonasekara, Michelle, Gooseman, Sheila, Gopal, Shameer, Gordon, Sally, Gorick, Hugh, Gormley, Stuart, Gorst, Michelle, Gorsuch, Thomas, Gosling, Rebecca, Goss, Henry, Gott, Naomi, Goudie, Elizabeth, Gould, Susan, Gouldbourne, Melonie, Gourbault, Lysander, Govind, Abha, Gowans, Sharon, Gowda, Girish, Gowda, Rohit, Gower, Hannah, Gower, Thomas, Grabowska, Diana, Graham, Clive, Graham, Donald, Graham, Jonathan, Graham, Justin, Graham, Sharon, Graham-Brown, Matthew, Grahamslaw, Julia, Grana, Gianluca, Grandison, Tracyanne, Grandjean, Louis, Grant, Alison, Grant, David, Grant, Matthew, Grant, Pauleen, Gravell, Rhys, Graves, Jenny, Gray, Alasdair, Gray, Catherine, Gray, Emily, Gray, Georgina, Gray, Glaxy, Gray, Jackie, Gray, Karen, Gray, Sebastian, Grayson, Alan, Greaves, Fiona, Greaves, Paul, Green, Charlotte, Green, Christopher, Green, Frederick, Green, Joel, Green, Marie, Green, Stacey, Greene, Diarra, Greenfield, Lawrence, Greenfield, Philippa, Greenhalgh, Alan, Greenwood, Daniel, Greer, Sandra, Gregory, James, Gregory, Jane, Gregory, Katie, Gregory, Tamsin, Greig, Jill, Greig, Julia, Grenfell, Rebecca, Grenier, Teena, Grevatt, Susan, Grey, Glaxy, Gribbin, Andrew, Griffin, Ben, Griffin, Denise, Griffin, Mel, Griffith, Sian, Griffiths, Andrew, Griffiths, Daniel, Griffiths, David, Griffiths, Donna, Griffiths, Isabel, Griffiths, Nicola, Griffiths, Oliver, Grigoriadou, Sofia, Grigsby, Steph, Gritton, Russell, Grobovaite, Evelina, Grondin, Clarissa, Groome, Rachel, Grosu, Liliana, Grounds, Jenny, Groves, Jayne, Grubb, Neil, Grundy, Julie, Guarino, Francesca, Gudur, Sharada, Gulati, Shivang, Gulia, Vikas, Gunasekera, Pumali, Gunganah, Kirun, Gunn, Jessica, Gunter, Emma, Gupta, Alok, Gupta, Atul, Gupta, Rajeev, Gupta, Richa, Gupta, Tarun, Gupta, Vineet, Gupta-Wright, Ankur, Gurram, Sambasivarao, Gurung, Ishy, Gurung, Shraddha, Guth, Hazel, Habibi, Ruth, Hackney, Pamela, Hacon, Christian, Haddad, Aiman, Hadfield, Denise, Hadjiandreou, Michalis, Haestier, Anna, Hafiz, Nauman, Hafiz-Ur-Rehman, Rana, Hagan, Samantha, Hague, Jack W, Hague, Rosemary, Haigh, Andrew, Haigh, Kate, Haines, Christina, Hainey, Scott, Hair, Morton, Hairsine, Brigid, Hajnik, Juraj, Haldeos, Anne, Halevy, Carmel, Halford, William, Hall, Alistair, Hall, Anthony, Hall, Chloe, Hall, Claire, Hall, Emily, Hall, Helen, Hall, Jennifer, Hall, Kathryn, Hall, Toni, Hallas, Jan, Hallas, Kyle, Hallett, Charles, Halls, Heather, Hamdollah-Zadeh, Maryam, Hameed, Bilal, Hamid, Imran, Hamie, Mohamad, Hamilton, Bethany, Hamilton, Fergus, Hamilton, Leigh, Hamlin, Ruth, Hamlyn, Eleanor, Hammersley, Shirley, Hammerton, Kate, Hammond, Bev, Hammond, Leah, Hammond-Hall, Rachel, Hammonds, Fiona, Hammoud, Nidal, Hamoodi, Ibrahim, Hampshire, Karen, Hampson, Jude, Han Lee, Shi, Hanci, Ozan, Hand, James, Handrean, Soran, Hands, Georgina, Hanif, Sheharyar, Hannington, Amy, Hannun, Merhej, Hanrath, Aidan, Hanson, Jane, Hanson, Kathryn, Haq, Mazhar U, Haqiqi, Ala, Haque, Monjurul, Harding, Zoe, Hardman, Simon, Haresh, Kumar, Harford, Rachel, Hargadon, Beverley, Hargreaves, Carolyn, Hargreaves, James, Harin, Alice, Haris, Mohammed, Harizaj, Helen, Harlock, Edward, Harman, Paula, Harman, Tracy, Harmer, Mark, Haroon, Muhammad A, Harper, Charlie H, Harper, Heather, Harper, Peter, Harper, Rosemary, Harrhy, Sarah, Harrington, Sian, Harrington-Davies, Yasmin, Harris, Claire, Harris, Jade, Harris, Julie, Harris, Laura, Harris, Marie-Clare, Harris, Nichola, Harrison, David, Harrison, Laura, Harrison, Melanie, Harrison, Rowan, Harrison, Susie, Harrison, Tom, Harrison, Wendy, Harrod, Elizabeth, Hart, Ciaran, Hart, Dominic, Hartley, Rosemary, Hartley, Ruth, Hartley, Tom, Hartrey, William, Hartung, Hans, Harvey, Alice, Harvey, Angela, Harvey, Max, Harwood, Catherine, Harwood, Helen, Hasan, Neda, Haselden, Brigitte, Hashimm, Mohammed, Hashmi, Imranullah, Haslam, Zena, Hassan, Abdulhakim, Hassan, Adil, Hassan, Ali, Hassan, Waqar Ul, Hassell, Philip, Hastings, Alex, Hastings, Bethany, Hatton, Jonathan, Haugh, Jennifer, Havinden-Williams, May, Havlik, Stefan, Hawcutt, Dan, Hawes, Liz, Hawes, Nicola, Hawkins, Annie, Hawkins, Nancy, Hawley, Daniel, Haworth, Edward, Hay, Cathy, Hayat, Jamal, Hayes, Anne, Hayes, Melony, Hayes, Fiona, Hayman, Antara, Hayman, Melanie, Haynes, Matthew, Haynes, Richard, Hayre, Rachel, Haywood, Patrick, Hazelton, Tracy, Hazenberg, Phoebe, He, Zhengmai, Headon, Elizabeth, Heal, Carrie, Healy, Brendan, Hearn, Amy, Heath, Angela, Heath, Rowan, Heaton, Diane, Hebbron, Kerry, Hedger, Neil, Hedges, Katrine, Heeley, Cheryl, Heeney, Elaine, Heire, Rajdeep, Helm, David, Hemmila, Ulla, Hemphill, Scott, Hemsley, Deborah, Henderson, Alistair, Henderson, Jennifer, Henderson, Steven, Henry, Joanne, Henry, Karol, Henry, Lavinia, Henry, Margo, Henshall, David, Herdman, Gillian, Herdmangrant, Rosaleen, Herrington, William, Heselden, Emilia, Heslop, Peta, Hester, Simon, Hetherington, Emily, Hetherington, Joseph, Hetreed, Andrew, Hettiarachchi, Chamila, Hettiarachchi, Gihan, Hewer, Hayley, Hewertson, John, Hewetson, Anna, Hewins, Sue, Hewitt, Claire, Hewitt, Davina, Hewitt, Richard, Heyderman, Robert S, Heydtmann, Matthis, Heys, Joseph, Heywood, Jonathan, Hibbert, Meg, Hickey, Naomi, Hicks, Alexander, Hicks, Jenny, Hicks, Scott R, Higbee, Daniel, Higgins, Jennifer, Higgins, Lucy, Higham, Andrew, Highcock, Martin, Highgate, Judith, Hikmat, Mondy, Hill, Amanda, Hill, Helen, Hill, Joanne, Hill, Phoebe, Hilldrith, Annette, Hillman-Cooper, Catherine, Hilton, Zoe, Hindmarsh, Alice, Hine, Paul, Hinshaw, Kim, Hird, Clare, Hives, Jemma, Ho, Benson, Hobden, David, Hobden, Gill, Hobrok, Maria, Hobson, Simon, Hodge, Simon, Hodgen, Lesley, Hodgkins, Holly, Hodgkinson, Sally, Hodgson, David, Hodgson, Helen, Hodgson, Luke, Hodgson, Sheila, Hodkinson, Gemma, Hodson, Kenneth, Hogben, Matthew, Hogg, Lucy, Hoggett, Lee, Holborow, Abigail, Holbrook, Becky, Holbrook, Catherine, Holden, Catherine, Holden, Jill, Holden, Melinda, Holder, Thomas, Holdsworth, Hannah, Holland, Lisa, Holland, Maureen, Holland, Nicky, Hollands, Marie, Holliday, Elizabeth, Holling, Nina, Hollister, Nigel, Hollos, Laszlo, Holmes, Evelyn, Holmes, Megan, Holmes, Raphael, Holmes, Rebecca, Holroyd, Kelly, Holt, Lyndsey, Holt, Siobhan, Holyome, Alexandra, Home, Marie, Hong, Kate, Hood, Andrew, Hooper, Clare, Hope, Samantha, Hope, Susan, Hopkins, Bridget, Horby, Peter W, Horler, Stephanie, Hormis, Anil, Horn, Rachel, Hornby, Nicola, Horrocks, Sophie, Horsford, Latoya, Horsford, Megan, Horsham, Valana, Horsley, Alex, Horsley, Ashley, Horsley, Elizabeth, Horton, Sarah, Hosea, Jane, Hoskins, Toby, Hossain, Ejaz, Hossain, Muhammad S, Hossain, Rashed, Hough, Maxine, Hough, Sarah, Houghton, Kathryn, Houlihan, Rebecca, Houston, Gordon, Houston, Hamish, Hoverd, Eleanor, Hovvels, Roseanna, How, Lee, Howaniec, Laura, Howard, Laura, Howard, Linda, Howard, Lucy, Howard, Sarah, Howard-Griffin, Richard, Howe, Serena, Howells, Mark, Howie, Lyn, Howlett, Alex, Howlett, Sophie, Hrycaiczuk, Josh, Hsu, Desmond, Htet, Hein, Htet, Zaw, Htoon, Naing Z, Htwe, Su, Hu, Ying, Huckle, Abby, Huda, Shahzya, Hudak, Alison, Hudig, Lisa, Hudson, Heather, Hufton, Alison, Huggins, Conor, Hughes, Alistair, Hughes, Emma, Hughes, Gareth, Hughes, Heather, Hughes, Luke, Hughes, Rachel, Hughes, Rhian, Hughes, Samantha, Hughes, Stephen, Hughes, Vikki, Hughes, Wesley, Huhn, Lukas, Hui, Ching, Hulbert, Ruth, Hull, Diana, Hull, Robert, Hulme, Amanda, Hulme, Peter, Hulse, Wendy, Hulston, George, Hum, Ryan, Humphrey, Charlotte, Humphries, Alasdair, Humphries, Joanne, Hunt, David, Hunt, Fiona, Hunt, Jane, Hunt, Kristen, Hunt, Luke, Hunter, Karl, Hunter, Neil, Hurditch, Elizabeth, Hurley, Cian, Hurley, Katrina, Husain, Mohammed A, Husaini, Syeda Y, Huson, Coralie, Hussain, Ibraar, Hussain, Mohammad, Hussain, Muhammad, Hussain, Reda, Hussain, Sajid, Hussain, Samia, Hussain, Sanniah, Hussain, Yasmin, Hussam El-Din, Mohammed, Hussey, Rebecca, Hutchcroft, Christopher, Hutchinson, Camille, Hutchinson, Dorothy, Hutchinson, Elizabeth, Hutchinson, John, Hutsby, Claire, Hutton, Paula, Hydes, Daniella, Hyde-Wyatt, Jamie, Hynes, Niamh, Hyslop, Megan, Ibrahim, Ahmed, Ibrahim, Asil, Ibrahim, Kamal, Ibrahim, Mohamed, Ibrahim, Wadah, Idrees, Muhammad, Iftikhar, Hina, Igwe, Chukwuemeka, Ijaz, Mohammad, Ikomi, Amaju, Iles, Clare, Iliodromiti, Stamatina, Ilves, Lorna, Imam-Gutierrez, La'ali, Imray, Christopher, Imtiaz, Haider, Ingham, Jack, Ingham, Julie, Ingham, Rory, Ingle, Tejas, Ingram, Anne, Ingram, Luke, Inns, Peter, Inweregbu, Ken, Ionescu, Andreea A, Ionita, Ana, Ipe, Anil, Iqbal, Madiha, Iqbal, Mohammed, Iqbal Sait, Faisal, Ireland, Jane, Irons, Robert, Irshad, Mohannad, Irshad, Muhammad S, Irvine, Janice, Irvine, Val, Irving, Robert, Ishak, Mina, Islam, Aminul, Islam, Munim, Islim, Abdurrahman, Ismail, Ali, Ismail, Omar, Israa, M'hamedi, Isralls, Sharon, Issa, Shabana, Ivan, Monica, Ivenso, Chineze, Ivy, Ashleigh, Iwanikiw, Sophie, Ixer, Karen, Iyer, Mia, Iyer, Sriram, Jackson, Alex, Jackson, Amanda, Jackson, Ben, Jackson, Ella, Jackson, Helen, Jackson, Lauren, Jackson, Melanie, Jackson, Nicola, Jackson, Shane, Jacob, Patricia, Jacob, Reni, Jacques, Nicola, Jafar, Anisa, Jaffery, Ali, Jagannathan, Vijay, Jagpal, Mandeep, Jaime, Fernandez R, Jain, Neemisha, Jain, Seema, Jain, Susan, Jaiswal, Sanjay, Jajbhay, Danyal, Jaki, Thomas, Jallow, Bintou, Jaly, Yusuf, Jamal, Sabine, Jameel, Yasmin, James, Albie, James, Anneli, James, Linda, James, Mark, James, Nicholas, James, Olivia, James, Ruth, James, Tracy, Jameson, Jack, Jamieson, Eleana, Jamison, Aaron, Jane, Phoebe, Janmohamed, Azara, Jansen, Lauren, Jansz, Sabrina, Japp, Deepa, Jardine, Catherine, Jarvie, Ellie, Jarvis, Rosina, Jastrzebska, Patrycja, Javed, Hafsa, Jawaheer, Lona, Jayachandran, Dinakaran, Jayaram, Deepak, Jayasekera, Geeshath, Jayasekera, Lalith, Jeddi, Saman, Jeelani, Mohammad S, Jeffery, Katie, Jeffrey, Rachel, Jeffreys, Nathan, Jeffs, Benjamin, Jegede, Debbie, Jemima, Taylor, Jenkin, Ifan, Jenkins, Alison, Jenkins, David, Jenkins, Elinor, Jenkins, Sarah, Jenkins, Sian, Jenkins, Stephen, Jenner, Edward, Jennings, David, Jennings, Jacqui, Jennings, Louise, Jennings, Virginia, Jerome, Ellen, Jerry, Douglas, Jessup-Dunton, Ellen, Jesus Silva, Jorge A, Jethwa, Kishan, Jeyabalan, Abi, Jha, Akhilesh, Jhanji, Shaman, Jian, Khoo, Jiao, Zhixin, Jimenez Gil, Ana, Jith, Jithin, Joefield, Teishel, Johal, Navraj, Johannessen, Karine, Johari, Aisyah, John, Annie, John, Anu, Johns, Emma, Johns, Margaret, Johnson, Antoinette, Johnson, Gillian, Johnson, Kathryn, Johnson, Luke, Johnson, Mark, Johnston, Claire, Johnston, Janet, Johnston, Susan, Johnston, Victoria, Johnstone, Dawn, Johnstone, Ed, Johnstone, Janet, Joishy, Manohar, Jones, Adam, Jones, Annabel, Jones, Bryony, Jones, Chrissie E, Jones, Carys, Jones, Charlotte, Jones, Gareth, Jones, Geraldine, Jones, Jac, Jones, James, Jones, Julie, Jones, June, Jones, Kate E, Jones, Laura, Jones, Laura M, Jones, Louise, Jones, Mathew, Jones, Nicola, Jones, Paul, Jones, Prudence, Jones, Quentin, Jones, Samantha, Jones, Sophie, Jones, Steve, Jones, Taya, Jones, Tim, Jones, Tracey, Jonnalagadda, Ramya, Jordache, Rebecca, Jorgensen, Sara, Jose, Sanal, Joseph, Anna, Joseph, Rosane, Joseph, Sibet, Joshi, Mehul, Joshi, Pratichi, Josiah, Benz, Joyce, Tiffany, Juan, Martin, Jude, Edward, Judge, Parminder, Juhl, Jessica, Jujjavarapu, Sirisha, Julie Melville, Julie, Juszczak, Edmund, Jyothish, Deepthi, Kabiru Dawa, Kasamu, Kacar, Mark, Kakoullis, Gail, Kala Bhushan, Azad, Kalayi, Richard J, Kaliannan Periyasami, Roobala, Kalsoom, Seika, Kam, Elisa, Kamara, Mohamed, Kamath, Ajay, Kamath, Prakash, Kamerkar, Siddharth A, Kametas, Nick, Kamfose, Musaiwale, Kanish, Amin, Kankam, Osei, Kannan, Thogulava, Kant, Abhinav, Kantor, Zoe, Kapoor, Ritoo, Kapoor, Sonal, Karunaratne, Nicholas, Kashif, Sobia, Kasianczuk, Natashja, Kasipandian, Vidya, Kassam, Jamila, Kassianides, Xenophon, Katsande, Victoria, Kaul, Kulbinder, Kaur, Daljit, Kaur, Dervinder, Kaur, Jasmin, Kaur, Jaspreet, Kausar, Zunaira, Kawser, Mohammad AA, Kay, Andrea, Kay, Sarah, Kayappurathu, Jossy N, Kaye, Callum, Kearsley, Nichola, Keating, Joanne, Keating, John, Keating, Liza, Keddie-Gray, Elizabeth, Keenan, Natalie, Kefas, Jonathan, Kegg, Stephen, Keith, Iain, Keith-Jopp, Chloe, Kellett, Joanne, Kelly, Alison, Kelly, Diane, Kelly, Dominic, Kelly, Emma, Kelly, Laura, Kelly, Martin, Kelly, Michael, Kelly, Rosalind, Kelly, Sinead, Kelly, Stephen, Kelly-Baxter, Mary, Keltos, Marketa, Kemp, Timothy, Kendall-Smith, Alexandra, Kennard, Sarah, Kennedy, Ann, Kennedy, James, Kennedy-Hay, Sophie, Kenny, Julia, Kent, Melanie, Keogan, Lynne, Keough, Alexander, Kerr, Andrew, Kerrison, Caroline, Kerry, Anthony, Kerss, Helen, Keshet-Price, Jocelyn, Keyte, Georgina, Khadar, Abdul, Khalid, Ali, Khalid, Muhammad U, Khalil, Amir, Khalil, Asma, Khalil, Sijjad, Khan, Ali, Khan, Al-Imran, Khan, Asad, Khan, Burhan, Khan, Fatimah, Khan, Kausik, Khan, Lubna, Khan, Malik A, Khan, Marria, Khan, Mohammad, Khan, Mohammed R, Khan, Nayeem, Khan, Omar, Khan, Rahila, Khan, Shabana, Khan, Shahul, Khan, Tasaduksultan, Khan, Waseem, Khatana, Usman F, Khatri, Jibran, Khatri, Jyoti, Khatun, Sagira, Khatun, Taslima, Khaw, Chuen R, Khin, Htet HE, Khokhar, Kiran, Khota, Najaf, Khurana, Chloe, Khurana, Shruti, Kibutu, Faith, Kidd, Andrew, Kidd, Michelle, Kidney, Joe, Kidney, Shane, Kieffer, Will, Kilby, Caroline, Kilich, Eliz, Kim, Jee Whang, Kimber, Sarah, King, Andy, King, Barbara, King, Jennifer, King, Kirsten, King, Rachel, King, Sam, King, Victoria, King-Oakley, Emily, Kingsmore, Laura, Kinney, Fiona, Kirk, Jeremy, Kirkby, Amy, Kirkham, Emily, Kirkman, Gemma, Kirwan, Ursula, Kitching, Toby, Kitto, Laura, Kittridge, Lauren, Klaczek, Sarah, Kmachia, Susan, Knapp, Christopher, Knibbs, Lucy, Knight, Alicia, Knight, Fraser, Knight, Marian, Knight, Sarah, Knight, Steven, Knight, Tom, Knights, Ellen, Knolle, Martin, Knott, Carol, Knowles, Karen, Knowles, Laurence, Knox, Emily, Knox, Lucy, Koch, Oliver, Kodituwakku, Ronan, Koduri, Gouri, Kolakaluri, Eirene, Kolodziej, Magdalena, Kolokouri, Eirini, Kon, Samantha, Kononen, Mari, Konstantinidis, Athanasios, Koopmans, Imogen, Korcierz, Laura, Korolewicz, James, Koshy, George, Kosmidis, Chris, Kotecha, Jalpa, Kothandaraman, Easwari, Kousar, Rukhsana, Kousteni, Margarita, Kozak Eskenazia, Alex, Krasauskas, Kestutis, Krejcarova, Zuzana, Krishnamurthy, Raghu, Krishnan, Manju, Krizak, Suzanne, Krupej, Sean, Kubisz-Pudelko, Agnieszka, Kudsk-Iversen, Soren, Kudzinskas, Aurimas, Kukadiya, Chirag, Kulkarni, Nainesha, Kumar, Aditi, Kumar, Ramesh, Kumar, Ravi, Kumar, Rita, Kumar, Ritesh, Kumar, Rupa, Kumar, Satish, Kumar, Vimal, Kundu, Arun, Kunst, Heinke, Kurani, Amit, Kurdy, Mohammed, Kurmars, Vimal, Kuronen-Stewart, Cameron, Kusangaya, Ranganai S, Kushakovsky, Vlad, Kuverji, Apexa, Kwek, Adriel JW, Kyei-Mensah, Amma, Kyere-Diabour, Thyra, Kyeremeh, Lynsey, Kyi, Moe, Kyi, Nyan M, Kyle, Laura, Kyle, Stuart, Kyriaki, Karali-Tsilimpari, Labao, Julius, Lacey, Louise, Lack, Nikki, Ladlow, Emma, Lafferty, Heather, Laha, Shondipon, Lahane, Sushil, Lai, Clement, Lai, James, Laing, Robert, Laing-Faiers, Inez, Laity, Emily, Lakeman, Nicki, Lalloo, David, Lalloo, Fiona, Lam, Sarah-Jane, Lamb, Fiona, Lamb, Thomas, Lambert, Pauline, Lameirinhas, Claudia, Lami, Mohammed KG, Lamparski, Michal, Lanaghan, Christine, Landers, Geraldine, Landray, Martin J, Lane, Matthew, Lane, Nicholas, Lang, Matilda, Lang, Stephen, Langer, Daniel, Langley, Maggie, Langoya, Charles, Langthorne, Emily, Langton, Helen, Latham, Scott, Latham-Mollart, John, Latheef, Afzal, Latt, Nang, Lau, Dawn, Lau, Eva, Laurenson, Myra, Law, Hou, Law, Jessica, Law, Penny, Law, Richard, Lawrence, Emma, Lawrie, Ryan, Lay, Michael, Laybourne, Stephen, Laycock, Christine, Layug, Reina, Lazo, Maria, Lea, Amelia, Lea, William, Leadbitter, Ian, Leafe, Samuel, Leahy, Thomas, Lean, Richard, Leandro, Lorna, Leaning, Darren, Leckie, Todd, Ledingham, Marie Anne, Lee, Emma, Lee, Hannah, Lee, Irish, Lee, Sam, Lee, Sindy, Lee, Stephanie, Lee, Tracey, Lee, Xiang, Lees, Diana, Legge, Helen, Leggett, Julian, Leigh-Ellis, Katie, Leitch, Nicky, Lekoudis, Eleni, Lemoine, Nicholas, Lennon, Liz, Lenton, Daniel, Leonard, Kelly, Leong, Wen, Leopold, Nicky, Leslie, Isla, Levell, Emma, Levett, Chris, Lewin, Alice, Lewis, Alison, Lewis, David, Lewis, Dee, Lewis, Joanne, Lewis, Joseph, Lewis, Kathryn, Lewis, Keir, Lewis, Leon, Lewis, Marie, Lewis, Marissa, Lewis, Megan, Lewis, Rob, Lewis-Clarke, Catherine, Lewiston, Katherine, Lewszuk, Adam, Lewthwaite, Penny, Ley, Samantha, Liaretidou, Anastasia, Licence, Victoria, Lieberman, David, Liebeschuetz, Susan, Lillie, Patrick, Lim, Ben, Lim, Carys, Lim, Ee T, Lim, Ivy, Lim, Terence, Lim, Wei Shen, Lim, Wilson, Limb, James, Limbu, Usha, Linden, Dermot, Lindenbaum, Lotte, Lindergard, Gabriella, Lindley, Kate, Lindsay, Emily, Ling, Mirella, Lingam, Claire, Linney, Mike, Linsell, Louise, Lipscomb, Karen, Lipskis, Laura, Lisboa, Ana, Lister, Evangeline, Little, Sam, Liu, Xuedi, Llanera, Daniel K, Llewelyn, Martin, Lloyd, Adam, Lloyd, Aimee, Lloyd, Arwel, Lloyd, Charlotte, Lloyd, Oliver, Lloyd, Richard, Lock, Lydianne, Lock, Sara, Lock, Stephen, Locke, Jacqueline, Locke, Thomas, Lockett, Teresa, Lockley-Ault, Gary, Loftus, Heather, Logan, Meg, Logue, Chloe, Loh, Sook Yin, Lokanathan, Siddharth, Loke, Tuck-Kay, Lomas, John-Paul, Lomme, Kaatje, London, Emily, Long, Charlotte, Long, Gabriella, Long, Natalie, Longhurst, Bev, Lonnen, Jennifer, Looby, Laura, Loosley, Ronda, Lopez, Pada, Lopez, Paula, Lord, Robert W, Lorimer, Claire, Loro, Francesco, Lorusso, Rachel, Loveless, Robert, Lovell, Maxine, Loverdou, Angeliki, Low, Andrew, Low, Jen Mae, Lowe, Alastair, Lowe, Catherine, Lowe, Emily, Lowe, Faye, Lowe, Michael, Lowsby, Richard, Lubina Solomon, Alexandra, Lucas, Georgia, Lucey, Alice, Luck, Suzanne, Luke, Jane, Lunn, Muriel, Luo, Ji, Luximon, Cindy N, Lyell, Barrie, Lynch, Ceri, Lynch, Daniel, Lynch, Daniella, Lynch, Stephen, Ma, Claire, Ma, Louise, Mabb, Hannah, Mabelin, Louies Andrew, Macaro, Jessica, Macconaill, Kateryna, MacCormac, Jill, MacDonald, Chloe, MacFadyen, Sheila, MacFarlane, James G, Macfarlane, Jill, Macfarlane, Laura, MacInnes, Lisa, MacIntyre, Jill, Mack, Kirsten, Mackay, Callum, Mackay, Euan, Mackenzie, Alexander, Mackenzie, Matt, MacKenzie Ross, Robert, Mackey, Ami, Mackie, Fiona, Mackie, Robert, Mackinlay, Carolyn, Mackintosh, Claire, Mackintosh, Katherine, MacLeod, Colin, MacLeod, Mary J, Macmahon, Michael, MacNair, Andrew, Macphee, Catherine, Macpherson, Iain, MacRaild, Allan, Madden, Alannah, Madden, Mary, Madeja, Norman, Madgwick, Paula, Madhusudhana, Madhavi, Madu, Alpha, Madziva, Lorraine, Mafham, Marion, Magavern, Emma, Maghsoodi, Negar, Magier, Christopher, Magriplis, Marios, Mahabir, Natasha, Mahadevan-Bava, Subramanian, Maharajh, Anjanie, Mahaveer, Ajit, Mahay, Bal, Mahdi, Hibo, Mahendiran, Thushika, Mahendran, Siva, Maher, Sarah, Maheswaran, Shameera, Mahjoob-Afag, Parisa, Mahmood, Ahmed, Mahmood, Farhana, Mahmoud, Hager, Mahmood, Mian, Mahmood, Waheed, Mahony, Ewan, Mair, Luke, Maitland, James, Major, Rupert, Majumdar, Jaydip, Majumder, Mohammad KH, Makin, Stephen, Malanca, Marius, Malcolm, Hannah, Malhan, Neeraj, Malik, Gulshan, Maljk, Mohammed, Mallinder, Petrina, Mallon, Louise, Malone, Edward, Maloney, Gracie, Mamman, Madhu, Man, Irene, Mancuso-Marcello, Marco, Mandal, Aritri, Manders, Tracy, Manderson, Lauren, Mandeville, Justin, Manhas, Roope, Maniero, Carmen, Mann, Bobby, Manoharan, Baranitharan, Mansi, Katherine, Mansour, Dina, Mapfunde, Isheunesu T, Mappa, Predeesh, Maraj, Hemant, Marayan, Gemma, Marchand, Clare, Marcus, Neil, Marecka, Maria, Margabanthu, Gomathi, Margalef, Jordi, Margarit, Lavinia, Margaritopoulos, Georgios, Margarson, Mike, Maria del Rocio, Fernandez M, Mariano, Victor, Maric, Ashleigh, Marriott, Arran, Marriott, Nemonie, Marsden, Karen, Marsden, Paul, Marsden, Tracy, Marsh, Robyn, Marshall, Adam, Marshall, Andrew, Marshall, Gail, Marshall, Henry, Marshall, Jaimie, Marshall, Jenna, Marshall, Nicola, Martin, Emmeline, Martin, Hayley, Martin, Hope, Martin, Jane, Martin, Karen, Martin, Laila, Martin, Michael, Martin, Sarah, Martin, Winston, Martindale, Tim, Martineau, Marcus, Martinelli, Anthony, Martinez, Lauren, Martinez Garrido, Jose Carlos, Maruthamuthu, Vijay K, Mary-Genetu, Roman, Maryosh, Sam, Masani, Vidan, Maseda, Diego, Mashate, Sheila, Mashhoudi, Yasaman, Masih, Sanna, Maskell, Nick, Maskell, Perry, Maskill, Jon, Masoli, Matthew, Mason, Richard, Mason, Ruth, Masood, Mohammad, Masood, Mohammad T, Masood, Syed, Masood, Syed SME, Matapure, Lear, Matei, Cristina, Matharu, Manraj, Mathen, Stephy, Mather, Nicole, Mathers, Jonathan, Matheson, Joanna, Mathew, Anna, Mathew, Verghese, Mathews, Jesha, Mathias, Kate, Matimba-Mupaya, Wadzanai, Matin, Nashaba, Matisa, Elina, Matonhodze, Max, Matovu, Elijah, Matthew, Szeto, Matthews, Alison Jane, Maureen, Edgar, Maxan, Maria-Emanuela, Maxwell, Adam, Maxwell, Veronica, May, James, May, Joanne, May, Peter, May, Philippa, Maycock, Matthew, Mayor, Shelley, McAlinden, Paul, McAlpine, Audrey, McAlpine, Graeme, McAndrew, Jonathan, McAuley, Hamish, McAuliffe, Sarah, McBurney, James, McCairn, Amanda, McCammon, Jake, McCann, Conor, McCarrick, Alexandra, McCarron, Brendan, McCarthy, Eoghan, McCarthy, Mandy, McCarthy, Michelle, McCarthy, Natalie, McCaughey, Sinead, McChlery, Gareth, McClay, Tara, McClelland, Beverley, McClintock, Declan, Mccord, Katherine, McCormick, Jacqueline, McCormick, Wendy, McCourt, Paul, McCrae, Jame, McCready, Sharon, McCreath, Gordan, McCreedy, Helen, McCullagh, Iain James, McCullagh, Liz, McCullough, Conor, McCullough, Katherine, McCullough, Sarah, McCurrach, Fiona, McDermott, Rory, McDevitt, Katharine, McDonald, Claire, McDonald, Debbie, McDonald, Emily, McDonald, Rob, McDonald, Sam, McDougall, Rowan, McEntee, Julie, McEvoy, Evanna, McEwen, Ruth, McFadden, Margaret, McFarland, Denise, McFarland, Rachel, McGettrick, Michael, McGhee, Christopher, McGill, Fiona, McGlinchey, Neil, McGlone, Phil, McGlynn, Deborah, McGoldrick, Claire, McGonagle, Sarah, McGough, Elizabeth, McGrath, Brendan, McGregor, Annemarie, McHugh, Tara, McIntyre, Karen, McIntyre, Mhairi, McIntyre, Zoe, McKain, Steve, McKay, Lorna, McKee, Madeleine, McKeever, Joseph, McKenna, Stewart, McKenzie, Julie, McKeogh, Donogh, Mckie, Laura, McKnight, Gerard, McLachlan, Heather, McLaren, Barbara, McLarty, Nicola, McLaughlin, Maria, McLay, James, McLure, Stewart, McMahon, Anne-Marie, McMahon, Genevieve, McMahon, Mike, McMaster, Moyra, McMaster, Paddy, McMeekin, Samuel, McMillan, Nicola, McMinn, Jason, McMorrow, Liam, McNally, Helen, McNeela, Fiona, McNeil, Lynne, McNeill, Claire, McNulty, Roisin, McParland, Christopher, McPhail, Mark, McQueen, Alison, McSkeane, Anna, McSorland, Denise, McTaggart, Gini, McTaggart, Jacqueline, McWilliam, Stephen, Mead, Joanna, Meadows, Emma, Mearns, Ben, Mearns, Claire, Mears, William, Meda, Manjula, Mediana, Ayren, Meehan, Sharon, Meeks, Emily, Megan, Abbi, Meghjee, Salim, Mehdi, Syed, Mehra, Rohan, Meiring, James, Mejri, Rayane, Melinte, Adriana-Stefania, Mellor, Francesca, Mellor, Samantha, Mellows, Katrina, Membrey, Helen, Menacho, Katia, Mendonca, Cheryl, Mentzer, Alexander, Menzies, Dan, Mepham, Sue, Mercer, Oliver, Mercer, Pauline, Merchant, Arwa, Merchant, Fatema, Meredith, Megan, Merida Morillas, Marta, Merritt, Jack, Merritt, Simon, Merwaha, Ekta, Message, Simon, Metcalf-Cuenca, Gabriel, Metherell, Stella, Metryka, Alexsandra, Mew, Louise, Meyrick, Simon, Mguni, Nhlanhla, Miah, Nahima, Micallef, Dariush, Michael, Alice, Michael, Shery, Michalak, Natalia, Middle, Janet, Middleton, Jennifer T, Middleton, Maeve, Middleton, Sophie, Mihalca-Mason, Loredana, Milburn, James, Milgate, Sarah, Millar, Colin, Millar, Jonathan, Millard, James, Miller, David, Miller, Rachel, Miller-Biot, Naomi, Millett, Louise, Milliken, Caitlin, Millin, Lisa, Millington, Katherine, Millington, Samuel, Mills, Helen, Mills, Janet, Millward, Helen, Miln, Rebecca, Milne, Alice, Milne, Charlotte, Milne, Zara, Milner, Joanne, Min, Zayar, Mindel, Samuel, Minnis, Christine, Minnis, Paul, Minton, Jane, Mires, Lucy, Mirza, Taimur, Misbahuddin, Anjum, Mishra, Aseem, Mishra, Biswa, Mishra, Eleanor, Mishra, Ritu, Misra, Sannidhya, Mistry, Deena, Mistry, Heena, Mital, Dushyant, Mitchard, Sarah, Mitchell, Alan, Mitchell, Ben, Mitchell-Inwang, Christine, Mitchelmore, Philip, Mitra, Andrew, Mitra, Atideb, Mitra, Sandip, Mizzi, Clarisse, Moatt, Emma, Modgrill, Gita, Mohamed, Arez, Mohamed, Osab, Mohammad, Waheed, Mohammed, Aliabdulla, Mohammed, Omer, Mohammed, Yaser NS, Moharram, Amr, Mok, Jonathan, Mole, Sean, Moller-Christensen, Christine, Mollet, Mateus, Molloholli, Malid, Molyneux, Andrew, Momoniat, Tasnim, Monaghan, Holly, Monaghan, Krista, Mongolu, Shiva, Moniz, Claudia S, Montasser, Mahmoud, Montgomery, Alan, Moodley, Prebashan, Moody, Alison, Moody, Margaret, Moody, Nick, Moon, Angela, Moon, James, Moon, Ji-Hye, Moon, Maria, Moonan, May, Moondi, Parvez, Moore, Barbara, Moore, David AJ, Moore, Faye, Moore, Judith, Moore, Laura, Moore, Sally, Moore, Thomas, Morales, Jose, Moran, Edward, Moran, Louise, Mordi, Richard, Moreno-Cuesta, Jeronimo, Morgan, Christine, Morgan, Colin, Morgan, Lauren, Morgan, Leila, Morgan, Matthew, Morgan, Patrick, Morgan-Jones, Katie, Morgan-Smith, Emily, Moriarty, Katie, Morley, Anna, Morley, Thomas, Morley, Wendy, Morris, Anna, Morris, Damian, Morris, Fiona, Morris, Katie, Morris, Lucy, Morris, Mary-Anne, Morris, Niall, Morris, Paul, Morris, Sheila, Morris, Susan, Morrison, Douglas, Morrison, Jennifer, Morrison, Moira, Morrissey, Mary, Morrow, Anna, Mortem, Gordon, Mortland, Valerie, Morton, Chelsea, Morton, Gordon, Moss, Alison, Moss, Charlotte, Moss, Sarah, Moss, Stuart, Motherwell, Nicki, Mouland, Johanna, Moulds, Caroline, Moulton, Hilary, Mousley, Elizabeth, Moxham, Karen, Moya, Borja, Mshengu, Eunice, Mtuwa, Sheila, Muazzam, Ali, Muazzam, Iqtedar A, Mudawi, Dalia, Muddegowda, Girish, Mughal, Ahsan, Muglu, Javaid, Muhammad, Javed, Muir, Carol, Mukhtar, Sabih, Mukhtar, Syed AA, Mukimbiri, Denise, Mulgrew, Peter, Mulhearn, Ben, Mulla, Arafat, Mullan, Dee, Mullasseril Kutten, Dileepkumar, Mullen, Niall, Mullett, Rosemary, Mulligan, Sandra, Mumelj, Lana, Mumford, Andrew, Munby, Henry, Munday, Hannah, Munro, Anne-Marie, Munt, Sheila, Murad, Arshid, Muralidhara, Koteshwara, Murdoch, Mhairi, Murira, Jennifer, Murphy, Alison, Murphy, Carl, Murphy, Gail, Murphy, Peter, Murphy, Sheenagh, Murphy, Simon, Murray, Clare, Murray, David, Murray, Eleanor, Murray, Lisa, Murray, Lorna, Murray, Tracey, Murthy, Mithun, Murton, Catherine, Muru, Neeka, Musanhu, Rosemary, Mushabe, Maimuna, Mustafa, Ahmed MM, Mustafa, Mustafa, Mustapha, Ibrahim, Mustufvi, Zhain, Mutch, Callum, Mutema, Eric, Muthukrishnan, Balakumar, Mutton, Sheree, Muzengi, Natasha, Mwadeyi, Memory, Mwale, Bettina, Mwaura, Esther, Myagerimath, Raji, Myers, Alice, Myers, Sam, Myint, Khin Swe, Myslivecek, Libor, Nadar, Evelyn, Nadeem, Iftikhar, Nadheem, Moosa, Naeem, Hassan, Naeem, Salman, Nafees, Samraiz, Nafei, Mohamed, Nagarajan, Thapas, Nagesh, Navin, Naguib, Mina, Naguleswaran, Kirushthiga, Nagumantry, K Shonit, Naicker, Kevin, Naidoo, Sarveshni, Naik, Gireesha, Naik, Samir, Nair, Devu S, Nair, Tanushree, Naismith, Kerry, Nallapareddy, Sri, Nallapeta, Soum, Nanda, Uttam, Nandani, Aarti, Naqvi, Ali R, Naqvi, Asadullah, Naqvi, Sara, Narula, Kavita, Nash, Dominic, Nasimudeen, Abdul, Nasir, Umer, Nassa, Heeam, Nasser, Tahir, Nasseri, Mariam, Natarajan, Anuja, Natarajan, Geetha, Natarajan, Nalin, Natarajan, Nikhila, Natarajan, Rajkumar, Nathaniel, Noel, Nathvani, Mala, Navaneetham, Neena, Navaratnam, Jeya, Navarra, Helen, Naveed, Sadaf, Navin, John, Nawaz, Khuteja, Nawaz, Shasta, Nayar, Bonilla, Naylor, Suzanne, Nayyar, Moez, Naz, Farrah, Naz, Mobeena, Nazir, Sehar, Nazir, Shaista, Ncomanzi, Dumisani, Ndefo, Onyine, Ndoumbe, Narcisse, Neal, Alan, Neary, Elaine, Negmeldin, Mostafa, Neill, Paula, Nejad, Avideah, Nelmes, Marian, Nelson, Marie, Nelson, Mark, Nelson, Scott, Nemane, Rajesh, Nepal, Samiksha, Nethercott, Dan, Netherton, Kimberley, Nettleton, Kimberley, Newby, Alison, Newby, Angela, Newby, David, Newcombe, Tracy, Newman, Charlotte, Newman, Diana, Newman, Joseph, Newman, Julie, Newman, Tabitha, Newman, Thomas, Newport, Rachel, Newson, Christopher, Newton, Maria, Ng, Anthony YKC, Ng, Sarah, Ng, Wee J, Ngan, Thomas, Ngui, Gabriel CE, Ngumo, Alice, Nguyen, Long, Nic Fhogartaigh, Caoimhe, Nicholas, Philip, Nicholas, Rachel, Nicholls, Donna, Nicholls, Ellie, Nicholls, Lisa, Nicholson, Alice, Nicholson, Anne, Nicholson, Annette, Nickson, Ian, Nicol, Elizabeth, Nicol, Rebecca, Nicola, Pantelis, Nicoll, Antony, Nikolaos, Pantzaris, Nikonovich, Georgii, Nilsson, Annette, Nimako, Kofi, Nimako, Louise, Ninan, Preethy, Nirmalan, Mahesh, Nisar, Muhammad, Nisbett, Toby, Nisha James, Aksinya, Nishiyama, Tomoko, Nishku, Glen, Nix, Sara, Nixon, Jennifer, Nixon, Maxine, Nizam Ud Din, Khwaja, Njafuh, Raymond, Nolan, Jeniffer, Noor, Zahid, Noori, Zaid, Norman, Louis, Norman, Rachel, Norris, Karen, Norris, Lillian, Nortcliffe, Sally Ann, North, Julie, North, Thomas, Northfield, John, Northover, Samantha, Nortje, Jurgens, Norton, Rowen, Notman, Holly, Nourein, Khalid, Nugdallah, Mohamed, Nugent, Justine, Nugent, Mark, Numbere, Numbere, Nundlall, Kribashnie, Nune, Arvind, Nunn, Kieran, Nunn, Michelle, Nunnick, Jane, Nupa, Yvonne, Nyamugunduru, Godfrey, Nyirenda, Maggie, Nyland, Kerry, Oakley, Amy, Oats, Paul, Obale, Begho, Obeng, Dorcas, Oboh, Clements, O'Brian, Marese, O'Brien, Clare, O'Brien, Julie, O'Brien, Kirsty, O'Brien, Linda, O'Brien, Neale, O'Brien, Rachel, O'Brien, Sarah, O'Brien, Tracey, O'Bryan, Emma, Obukofe, Ross, O'Callaghan, Christopher, O'Connell, Lorcan, OConnor, Tadg, O'Connor, Chris, O'Connor, Grainne, Odam, Miranda, Oddie, Sam, Oddy, Sharon, Odedina, Yejide, Odelberg, Sven W, Odell, Natasha, Odone, Jessica, O'Donovan, Catherine, Offord, Pamela, Ogbara, Tanwa, O'Gorman, Ciaran, Ogunkeye, Oluwatomilola, Ohia, Udeme, Ohja, Shinjali, Ojo, Ohiowele, O'Kane, Mark, Okeke, Tolu, OKell, Eleanor, Okines, Alicia, Okpala, Iheoma, Okpo, Ernest, Okubanjo, Maryanne, Olaiya, Raphael, Old, Tim, Oleszkiewicz, Gregory, Oliver, Annie, Oliver, Catherine, Oliver, Jesse, Oliver, Zoe, Olufuwa, Olumide, Olukoya, Olatomiwa, O'Malley, Laura, Omar, Maryam, Omar, Zohra, O'Neill, Lauran, Ong, Chon Sum, Onyeagor, Chidera, Onyirioha, Tobenna, Ooi, Huah Chiang, Oram, Richard, Orchard, William, Ord, Jonathan, O'Reilly, Paula, O'Riordan, Devaki, O'Riordan, Sean, Orme, Amy, Orme, Hannah, O'Rourke, William, Orr, Charlotte, Orr, Sarah, Osadcow, Anna, Osagie, Rawlings, Osborne, Lynn, Osborne, Nigel, Osborne, Rebecca, Osborne, Wendy, O'Shea, Bee, O'Shea, Daire, Osman, Wa'el, O'Sullivan, Eoin, O'Sullivan, Susan, Otite, Otueroro K, O'Toole, Marie, Owen, Rachel, Owen, Stephanie, Owoseni, Yetunde, Owston, Michael, Oxlade, Ruth, Packham, Sophie, Paczko, Piotr, Padden, Grace, Padmakumar, Anand, Page, Iain, Page, Valerie, Paget, Jodi, Pagett, Katherine, Pai, Anirudda, Pakozdi, Angela, Palacios, April, Palagiri Sai, Vishnu B, Palaniappan, Vadivu, Palanivelu, Priya, Palfreeman, Adrian, Palit, Deepshikha, Palmer, Alistair, Palmer, Lynne, Palmer, Sue, Pamphlett, Ian, Pandey, Anmol, Pandian, Nithya, Pandya, Krishnaa, Panes, Alice, Pang, Yee W, Pannell, Laura, Panthakalam, Sathianathan, Pantin, Charles T, Papaconstantinou, Helen, Papineni, Padmasayee, Paques, Kitty, Paradowski, Kerry, Parambil, Vinay, Paranamana, Supathum, Paranthamen, K Sri, Parekh, Amy, Parfrey, Helen, Parikh, Omi, Parish, Gemma, Parker, Angela, Parker, Ben, Parker, Emma, Parker, Julie, Parker, Laura, Parker, Lucy, Parkinson, Craig, Parkinson, Valerie, Parmar, Aneel, Parmar, Chetan, Parmar, Viraj, Parris, Victoria, Parrott, Megan, Parry, Helen C, Parslow-Williams, Siobhan, Parson, Mark, Parsonage, Maria, Parsons, Penny, Partridge, Richard, Passby, Lauren, Patal, Mital, Patch, Sarah, Patel, Aamie, Patel, Alkesh, Patel, Amisha, Patel, Dakshesh, Patel, Darshna, Patel, Hemani, Patel, Jaymik, Patel, Kayur, Patel, Kirin, Patel, Krish, Patel, Manish, Patel, Mehul, Patel, Nehalbhai, Patel, Prital, Patel, Soonie, Patel, Vishal, Pathak, Sangeeta, Pathan, Nazima, Pathvardhan, Chinmay, Patience, Alexandra, Patience, Donna, Patrick, Abigail, Patrick, Georgie, Patrick, Jean, Patten, Simon, Pattenden, Ben, Patterson, Charlotte, Patterson, Linda, Patterson, Molly, Patterson, Robert, Pattison, Natalie, Pauls, Leigh, Paulus, Stephane, Pavord, Susan, Payne, Brendan, Payne, Elizabeth, Payne, Ruth, Peacock, Linda, Peacock, Louise, Peake, Henry, Pearson, Andrew, Pearson, Daniel, Pearson, Harriet, Pearson, Karen, Pearson, Samuel A, Pearson, Sandra, Peasley, Alice, Peddie, Hilary, Peek, Russell, Pegg, Claire, Peglar, Suzannah, Pemberton, Abigail, Penacerrada, Melchizedek, Pender, Anthony, Pendlebury, Carmel, Penfold, Rachel, Penhaligon, Kate, Penman, Catherine, Penman, Julie, Penny, James, Pepperell, Justin, Pereira, Adriana, Pereira, Rita, Perez, Elena, Perez, Jane, Perinpanathan, Tanaraj, Periyasamy, Lakshmi, Perry, Alison, Perry, Emily, Perry, Meghan, Pessoa-Amorim, Guilherme, Petch, Ruth, Peter, Lionel, Peters, Cecilia, Peters, Mark, Peters, Steve, Peters, Tim, Peterson, Alexandra, Peto, Leon, Petrou, Ilianna, Petrova, Boyanka, Petrova, Mirela, Pfeffer, Paul, Phanish, Mysore, Phelan, Paul, Philbey, Christopher, Philbin, Jennifer, Phillips, Alex, Phillips, Dylan, Phillips, Rachael, Phipps, Marie, Phongsathorn, Virach, Phoo, Nang T, Phull, Mandeep, Phulpoto, Masroor M, Pick, Sara, Pickard, James, Pickering, Charlotte, Pickering, Gillian, Pickett, Thomas, Pickles, Joanna, Pickwell-Smith, Benjamin, Pieniazek, Natalia, Pieris, Angelo, Pilgrim, Samia, Pillai, Paul Anthony, Pilsworth, Zoe, Pinches, Heather, Pinches, Stacey, Pine, Kirsty, Pineles, Ed, Pinjala, Muni T, Pintus, Stefania, Piper, Graeme, Pirani, Tasneem, Pitts, Sally, Plant, Aiden J, Platt, Naomi, Pleass, Robert, Plummer, Laura, Plumptre, Charles, Pogreban, Tatiana, Pointon, Joshua, Poku, Stephen, Pollard, Rachel, Pollock, Louisa, Poluyi, Oluwamayowa, Polwarth, Gary J, Pomery, Fiona, Ponnusamy, Ponmurugan, Ponnuswamy, Aravind, Ponte Bettencourt dos Reis, Inês, Poole, Alice, Poole, Lynda, Poole, Michele, Poon, Sharon, Poonian, Tajinder, Porter, David, Porter, Linda, Postlethwaite, Kelly, Pothina, Narayana, Potla, Priyadarshan, Potoczna, Dorota, Pott, Jason, Potter, Alison, Potter, Jean, Potter, Sarah, Potton, Elspeth, Potts, Julie, Potts, Kathryn, Poulaka, Maria, Poultney, Una, Poulton, Katherine, Poustie, Vanessa, Powell, James, Powell, Jordan, Power, Deborah, Power, Nick, Poxon, Joseph, Poyner, Robin, Prady, Helena, Prasad, Krishna, Prasanth Raj, Fredy, Prasath, Sangeetha, Pratley, Anezka, Pratt, Euan, Pratt, Steven, Preiss, David, Prendergast, Claire, Prentice, Lynn, Prescott, Verity, Presland, Laura, Prest, Catharine, Preston, Stephen, Prevatt, Natalie, Prew, Sandra, Price, Ashley, Price, Carly, Price, Claire, Price, David, Price, Elizabeth, Price, Nathan, Price, Vivien, Priest, Anne, Priestley, Kate, Primrose, Lorraine, Prince, Judith, Prince, Laura, Pringle, Shirley, Pristopan, Veronika, Pritchard, Kelly, Pritchard, Lucy, Pritchard, Simon, Priyash, Verma, Procter, Andrew, Proctor, Clare, Proudfoot, Rebecca, Prowse, Heather, Prudon, Benjamin, Pryor, David, Pudi, Solomon, Pugh, Amy, Pugh, Joanne, Pugh, Mark, Pugh, Nichola, Pugh, Richard, Puisa, Veronika, Punia, Kirandip, Punnilath Abdulsamad, Saleel, Purandare, Laura, Purcell, Martha, Purdue, Corrina, Purewal, Bally, Pursell, Molly, Purssord, Gregory, Purvis, Sarah, Puxty, Kathryn, Pynn, Michael, Qadeer, Tariq, Quaid, Sheena, Quayle, Alice, Quayle, Ian, Quenby, Siobhan, Qui, Xinyi, Quick, Vanessa, Quigley, Julie, Quinn, Tom, Quratulain, Quratulain, Qureshi, Danya, Qureshi, Hasanain, Qureshi, Khadija, Qureshi, Nawaz, Qurratulain, Qurratulain, Qutab, Saad, Rabbani, Muhammad S, Raceala, Madalina, Rad, Laura, Radford, Jane, Radford, Liz, Radhakrishnan, Jayachandran, Raffles, Michael, Rafique, Cecillia, Rafique, Muhammad, Ragatha, Ravi, Raghunath, Sarika, Raghunathan, Aiswarya, Raguro, Abigail, Raha, Shankho D, Rahama, Sana, Rahilly, Karen, Rahim, Faisal, Rahimi, Haseena R, Rahman, Muhammad, Rahman, Salim Ur, Raisova, Lenka, Raithatha, Mehul, Raj, Arjun, Rajagopalan, Pradeep, Rajaiah, Nithy, Rajasekaran, Arvind, Rajasri, Aylur, Rajeswary, Jyothi, Rajmohan, Gayathri, Ram, Matsa, Ramabhadran, Balaji, Ramachandran, Niranjani, Ramadan, Iyad, Ramali, Mohamed, Ramanan, Athimalaipet, Ramanna, Shashikira, Ramasamy, Maheshi, Ramdin, Dhanishta, Ramirez, Jozel, Ramos, Lidia, Ramraj, Shanthi, Ramsawak, Lisa, Ramshaw, Alex, Rana, Aleem, Rana, Ghulam F, Rana, Rehman, Rand, Abby, Rand, James, Randell, Georgina, Ranga, Poonam, Rangar, Manu, Rangarajan, Harini, Ranjan, Sameer, Ranka, Poormina, Ranns, Christopher, Rao, Anita, Rao, Deepak, Rao, Sandhya, Rao, Sanjay, Rashid, Khalid, Ratcliff, Simbisai, Ratcliffe, Sam, Ratcliffe, Sophy, Rath, Sanjeev, Rather, Mohmad I, Rathore, Selina, Ratnakumar, Aravinden, Ratoff, Jonathan, Rattehalli, Deepa, Raw, Jason, Ray, Gautam, Ray, Samiran, Raymond-White, Adam, Raynard, Dana, Rayner, Nicola, Raza, Jareer, Razvi, Salman, Razvi, Zarine, Read, Kerry, Reddy, Ajay, Reddy, Anvesh, Reddy, Harsha, Reddy, Ravi, Redfern-Walsh, Aine, Redome, Alex, Redome, Joan, Reed, Anna, Rees, Andrew, Rees, James, Rees, Martyn, Rees, Sarah, Rees, Stephanie, Rees, Tabitha, Regan, Fiona, Regan, Karen, Regan, Susan, Rege, Kanchan, Rehan, Ahmed, Rehman, A, Rehman, Siddiqur, Reid, Ada, Reid, Jeremy, Reid, Sharon, Reilly, Mkyla, Reith, Christina, Remegoso, Alda, Rengan, Dinakaran, Renshaw, Stephen, Renu Vattekkat, Remya, Reschreiter, Henrik, Rewitzky, Glynis, Reynard, Charles, Reynish, Dominic, Reynolds, Jessica, Reynolds, Peter, Reynolds, Tom, Rhead, Kat, Rhodes, Jo, Rhodes, Jonathan, Riaz, Naghma, Rice, Emily, Rice, Matthew, Rich, Mel, Richards, Alison, Richards, Suaznne, Richardson, Celia, Richardson, Neil, Richardson, Nicky, Riches, Joanne, Riches, Katie, Ricketts, William, Riddell, Anna, Riddles, Laura, Ridley, Carrie, Ridley, Paul, Rieck, 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Rokadiya, Sakib, Rollins, Lee, Rollo, Jennifer, Rolls, Catherine, Rook, Claire, Rooney, Kevin, Rooney, Laura, Rooney, Lynsey, Rosaro, Lace, Rose, Alastair, Rose, Annie, Rose, Steve, Rose, Zoe, Rosier, Josephine, Rossdale, Jennifer, Rossi, Sabrina, Ross-Parker, Andrew, Rothman, Alex, Rothwell, Joanne, Roughley, Lindsay, Rousseau, Guy, Rowan, Kathy, Rowan, Neil, Rowan, Stephen, Rowe-Leete, Louise, Rowlands, Benjamin, Roy, Aparajita, Roy, Subarna, Roynon-Reed, Anna, Rozewicz, Sam, Rubino, Antonio, Rudenko, Anna, Rudrakumar, Senthan, Rudran, Banu, Ruff, Shannon, Rughani, Prita, Ruiz, Mike, Rundell, Sharon, Rupani, Hitasha, Rusk, Darren, Russell, Joseph, Russell, Peter, Russell, Richard, Russo, Cristina, Rutgers, Marieke, Ryan, Aidan, Ryan, Brendan, Ryan, Lucy, Ryan, Matthew, Ryan, Pat, Ryan, Phil, Ryan-Wakeling, Declan, Saad, Chloe, Saad, M, Sabale, Javeson, Sabaretnam, Suganya, Sacher, Gorka, Sadiq, Noman, Saffy, Ashiq, Sagar, Diaeddin, Sage, Beth, Sagoo, Harkiran, Saha, Rajnish, Sahdev, Nikhil, Sahota, Jagdeep, Said, Nooria, Sakthi, Sreekanth, Salam, Abdul, Salciute, Erika, Sale, Jessica, Saleeb, Gina, Saleh, Mumtaz, Salih, Hizni, Salih, Laylan, Salisbury, Sarah, Salman, Rustam, Salmon, Jenny, Salutous, Dario, Sam, Mfon, Sam, Sally, Samakovna, Tinashe, Saman, Razan, Samlal, Renaldo, Sammons, Emily, Sammut, David, Sammut, Mark, Sampath, Sunitha, Sampson, Julia, Samson, Anda, Samuel, Debbie, Samuel, Johnson, Samuel, Reena, Samuel, Thomas DL, Samuels, Elsward, Samuels, Theo, Samways, Joanna, Samyraju, Manjula, Sana, Ilves, Sanaullah, Aabid, Sanchez, Veronica, Sanchez, Amada, Sanctuary, Tom, Sandercock, Peter, Sanderson, Amy, Sanderson, Paul, Sanderson, Tom, Sandhu, Kuljinder, Sandhu, Loveleen, Sandrey, Victoria, Sands, Sarah, Sangombe, Mirriam, Sanju, Matthew, Santosh, Rojy, Sanyal, Jayanta, Sanz-Cepero, Aureo F, Saqib, Najam, Sarai, Sarbjit, Saralaya, Dinesh, Saraswatula, Arun, Sarfatti, Avishay, Sargent, Rebecca, Sari, Beatrix, Sarkar, Rahul, Sarma, Sruthi, Sarodaya, Varun, Sarwar, Zainab, Sass, Thea, Sathe, Sonia, Sathianandan, Sobitha, Sathyanarayanan, Abilash, Sathyapalan, Thozhukat, Satodia, Prakash, Saunders, Rachel, Saunders, Samantha, Saunderson, Anne, Savill, Heather, Savlani, Karishma, Saxton, Matthew, Sayan, Amrinder, Scaletta, Diane, Scarratt, Lyndsay, Scattergood, Sean, Schadenberg, Alvin, Schoolmeesters, Alex, Schumacher, Natasha, Schunke, Nicola, Schuster Bruce, Martin, Schwarz, Karin, Scorrer, Tim, Scothern, Fiona, Scott, A, Scott, Anne, Scott, Christine, Scott, Emily, Scott, Kerrie, Scott, Stephen, Scott, Timothy, Scourfield, Sarah, Scrase, Wendy, Scullion, Angela, Seager, Emily, Seagrave, Cathy, Sear, Eleanor, Seaton, Isabella, Seckington, Anna, Sedano, Joanna, Seddon, Gabrielle, Seelarbokus, Muhammad A, Sefton, Christopher, Segovia, Matias, Sekadde, Gillian, Selby, Georgina, Sellers, Katharine, Selley, Joseph, Sellick, Victoria, Selvadurai, Gobika, Selvarajah, Brintha, Selvaskandan, Haresh, Semple, Gary, Sen, Nandini, Sen, Seema, Sengreen, Namrita, Sengupta, Aditya, Sengupta, Niladri, Senya, HoJan, Sethi, Jaskaran, Setty, Niranjan, Seward, Abigail, Sewdin, Teswaree, Seymour, Jack, Shafi, Tariq, Shah, Aashni, Shah, Ahmar, Shah, Anand, Shah, Anjnee, Shah, Bhavni, Shah, Neil, Shah, Pallav, Shah, Priyank, Shah, Qasim, Shah, Sarfaraz H, Shah, Snehal, Shah, Suraj, Shah, Syed, Shahi, Sousan, Shahnazari, Sipan, Shahrul, Ramli, Shahzeb, Muhammad, Shaikh, Amina Y, Shail, Rajit, Shaji, Mariya, Shalan, Korah, Shami, Nafe, Shamim, Nadia, Shams, Kazi, Shanahan, Thomas, Shannon, Paul, Sharaf, Hamed, Sharif, Asir, Sharma, Akhilesh, Sharma, Ash, Sharma, Mona, Sharma, Ojasvi, Sharma, Rajeev, Sharma, Sanjeev, Sharma, Sarkhara, Sharp, Alexander, Sharp, Charles, Sharp, Gemma, Sharratt, Paula, Sharratt, Phoebe, Shaw, Christopher, Shaw, David, Shaw, Deborah, Shaw, Joanne, Shaw, Jonathan, Shaw, Lisa, Shaw, Tomos G, Shawcross, Anna, Shawe, Jill, Shedwell, Sophy, Sheffield, Jonathan, Shehata, Zak, Sheik, Arshiya, Sheikh, Asif, Sheikh, Noorann, Shelley, Benjamin, Shelton, Sarah, Shenoy, Anil, Shenton, Julie, Shepherd, Amy, Shepherd, Lorna, Shepherd, Scott, Sheppeard, Rhian, Sheridan, Helen, Sheridan, Ray, Sherridan, Samuel, Sherris, Leanne, Sherwin, Susanna, Shibly, Shaad, Shields, Norma, Shioi, Chiaki, Shipp, Lucy, Shirgaonkar, Anand, Shirley, Kim, Shonubi, Adebusola, Shotton, Rohan, Shotton, Sarah, Shpuza, Ervin, Shrestha, Nora, Shuker, Karen, Shurmer, Jack, Siamia, Loria, Siddavaram, Seshnag, Siddique, Nasir, Siddique, Sohail, Sikondari, Nyma, Sim, Malcolm, Sime, Robert, Simmons, Oliver, Simms, Richard, Simpson, Angela, Simpson, Anna, Simpson, Danny, Simpson, Georgina, Simpson, Kathryn, Simpson, Kerry, Simpson, Phillip, Simpson, Thomas, Sinclair, Janet, Singh, Ankita, Singh, Claire, Singh, Jayaprakash, Singh, Jyoti, Singh, Manjeet, Singh, Nadira, Singh, Pankaj, Singh, Prabhsimran, Singh, Salil, Singhal, Parag, Singham, Surendra, Singizi, Bryan, Sinha, Manas, Sinha, Sharad, Sinha, Utkarsh, Sisson, Guy, Sivakumar, Karthikadevi, Sivakumar, Shanmugasundaram, Sivakumaran, Darshi, Sivanadarajah, Sivanthi, Skehan, Nicole, Skelly, Robert, Skelton, Jill, Skelton, Orlagh, Skene, Imogen, Skinner, Denise, Skinner, Tabitha, Skinner, Victoria, Skorko, Agnieszka, Skorupinska, Iwona, Skorupinska, Mariola, Slack, Amy, Slack, Katie, Slade, Heather, Slade, Mark, Slater, Holly, Slater, Lynda, Slawson, Nicola, Sloan, Andrew, Sloan, Brendan, Sloan, Derek, Sluga, Grace, Small, Ellen, Small, Samuel, Smallshaw, Karen D, Smallwood, Andy, Smit, Carien, Smith, Aileen, Smith, Amanda, Smith, Amy, Smith, Andrew, Smith, Catherine, Smith, Chris, Smith, Christopher, Smith, Dominic, Smith, Eleanor, Smith, Hazel, Smith, Helen, Smith, Jacky, Smith, Jeannette, Smith, Jessica, Smith, John, Smith, Kate, Smith, Kerry, Smith, Lara, Smith, Lesley, Smith, Linda, Smith, Lisa, Smith, Loren, Smith, Lucy, Smith, Matthew, Smith, Mel, Smith, Rachel, Smith, Rebecca, Smith, Richard, Smith, Sally, Smith, Stacey, Smith, Stephanie, Smith, Susan, Smolen, Sue, Smuts, Sara, Smyth, Jennifer, Smyth, Naoise, Snell, Anette, So, Alfred, So, Beng, Soan, Michelle, Sobande, Toluleyi, Sobrino Diaz, Alberto, Sohail, Basit, Sohail, Bina, Soiza, Roy, Solademi, Olajumoke, Soleimani, Babak, Solesbury, Amanda, Solomon, Louise, Somalanka, Subash, Somashekar, Chandrashekaraiah, Sonia, Raj, Soo, Shiu-Ching, Soren, Jennifer, Sorice, Vittoria, Sothinathan, Apina, Sothirajah, Pragalathan, Soto, Carmen, Soussi, Najwa, Southam, Donna, Southern, David, Southern, Iain, Southern, Louise, Southin, Sara M, Southworth, Thomas, Sowter, Jason, Spalding, Claudia, Spata, Enti, Spears, Katie, Spears, Mark, Spencer, Branwell, Spencer, Gisele, Spencer, Sue, Spickett, Helen, Spillane, Jennifer, Spiller, William, Spinks, Kerry, Spinks, Michelle, Spittle, Nick, Sporrer, Johanna, Spring, Oliver, Squires, Gemma, Squires, Jack, Squires, Rebecca, Sreenivasan, Ram, Srinivasan, Ramesh, Srirajamadhuveeti, Asha, Srirathan, Vino, Stacpoole, Sybil, Stadon, Louise, Stahle, Jennifer, Staines, Nikki, Stanciu, Roxana, Stanczuk, Grazyna, Stapley, Simon, Staplin, Natalie, Starr, Michelle, Stead, Rachael, Steele, Conor, Stefanowska, Paula, Stephens, Alison, Stephensen, David, Stephenson, Courtney, Stephenson, Elaine, Sterrenburg, Monique, Stevens, Will, Stevenson, Amy, Stevenson, Andrew, Stevenson, Daniel, Stevenson, Lesley, Stevenson, Sarah, Stewart, Claire, Stewart, Grant, Stewart, Richard, Stickley, Jo, Stidolph, Beverley, Stiller, Gemma, Stirrup, Sarah, Stock, Sarah, Stockdale, Alexander, Stockham, Lynne, Stoddard, Emma, Stokes, Chris, Stone, Ben, Stone, Sarah, Stone, Sophia, Storey, Imogen, Storton, Kim, Stourton, Frederick, Strachan, Angela, Stratton, Emma, Stratton, Jane, Straw, Sam, Streit, Dieter, Stride, Emma, Stringer, Sally, Strong-Sheldrake, Sophia, Struik, Siske, Stuart, Carmel, Stubbs, Anna, Stubbs, Harrison, Sturdy, Ann, Sturney, Sharon, Stuttard, Matt, Suarez, Cristina, Subba, Karuna, Subbe, Chris, Subramanian, Manjula, Subramanian, Vaidyanathan, Subramanian, Venkatram, Subudhi, Chinari, Suckling, Rebecca, Sudershan, Srivatsan, Sugai, Taku, Sugden, Peter, Sukla, Rudresh, Suliman, Ali, Suliman, Fatimah, Sultan, Sugrah, Summers, Alasdair, Sundar, Samyukta, Sundhar, Reka, Sunni, Nadia, Suntharalingam, Jay, Sur, Amitava, Suresh, Dharmic, Suresh, Shilpa, Surtees, Michael, Suter, Danielle, Sutherland, Helen, Sutherland, Rebecca, Sutinyte, Dovile, Sutton, Deborah, Sutton, Sam, Sutton-Cole, Amy, Sutu, Mihaela, Svensson, Marie-Louise, Svirpliene, Sima, Swain, Andrew, Swaine, Thomas, Swarnkar, Keshav, Swart, Tirion, Swift, Ealish, Swift, Pauline, Swift, Rachael, Swingler, Rachel, Swinhoe, Sophie, Swist-Szulik, Katarzyna, Swithenbank, Luke, Syed, Yasir, Sykes, Catriona, Sykes, Daisy, Symon, Dominic, Symon, Lesley, Syson, Jen, Szabo, Gemma, Szakmany, Tamas, Szekely, Megan, Szeto, Matthew, Tadros, Maria, Tague, Lucy, Tahir, Hasan, Takyi, Abigail, Talbot-Ponsonby, James, Tallon, Bradley, Tan, Bee TT, Tan, Hock, Tan, Huey, Tan, WeiTeen, Tana, Anand, Tangney, Rebecca, Tanney, Christina, Tanqueray, Tabitha, Tanton, Emma, Tarft, Hayley, Tariq, Syed, Tarpey, David, Tasiou, Antonia, Tatam, Elizabeth, Tate, Margaret Louise, Tate, Paul, Tatham, Kate, Tavoukjian, Vera, Taylor, Alexander, Taylor, Andrew, Taylor, Beverley, Taylor, Claire, Taylor, David, Taylor, Jennifer, Taylor, Joanne, Taylor, Julie, Taylor, Karen, Taylor, Leanne, Taylor, Margaret, Taylor, Matthew, Taylor, Melanie, Taylor, Natalie, Taylor, Rachael, Taylor, Rachel, Taylor, Samantha, Taylor, Suzanne, Taylor, Tracey, Taylor, Vicky, Taylor-Siddons, Michelle, Taynton, Thomas, Te, Amelia, Teasdale, Jessica, Tebbutt, Julie, Tee, Caroline, Telfer, Adam, Teli, Vibha, Tempany, Jennifer, Temple, Julie, Temple, Natalie, Tench, Helen, Teoh, Yi He, Terrett, Lynne, Terry, Louise, Terry, Louise, Tetla, Dariusz, Tewkesbury, Daniel, Thakker, Manish, Thankachen, Mini, Tharmaratnam, Dushen, Thatcher, Hilary, Thayanandan, Andrew, Thazhatheyil, Krishna, Thein, Eaint, Theron, Byron, Thet, Phyu, Thevarajah, Kapeendran, Thillainathan, Brinda, Thirlwall, Yvette, Thirumaran, Muthu, Thomas, Alice, Thomas, Amy, Thomas, Andrew, Thomas, Emma, Thomas, Enson, Thomas, Esther, Thomas, Helen, Thomas, James, Thomas, Karen, Thomas, Koshy, Thomas, Lucy, Thomas, Megan, Thomas, Rachel, Thomas, Rebecca, Thomas, Rhys, Thomas, Ruth, Thomas, Sarah, Thomas, Sherine, Thomas, Tessy, Thomas, Vicky, Thomas-Turner, Rhian, Thompson, Catherine, Thompson, Christopher, Thompson, Clara, Thompson, Fiona, Thompson, Katharine, Thompson, Laura, Thompson, Liz, Thompson, Orla, Thompson, Roger, Thomson, Jason, Thomson, Nicola, Thorn, Natasha, Thorne, Charlotte, Thorne, Nicola, Thornton, Jim, Thornton, Richard, Thornton, Sarah, Thornton, Susan, Thornton, Thomas, Thorpe, Christopher, Thorpe, Sarah, Thozthumparambil, Paradeep, Thrasyvoulou, Laura, Thraves, Hannah, Thwaites, Guy, Tiberi, Simon, Tieger, Serena, Tierney, Carey, Tierney, Caroline, Tighe, Mark, Tilbey, Sorrell, Tiller, Amanda, Timlick, Elizabeth, Timms, Hayley, Timoroksa, Anne-Marie, Tinashe, Samakomva, Tinkler, Heather, Tinkler, Marianne, Tipper, Jacqui, Tisi, Sophie, Tivenan, Helen, Tluk, Suzy, T-Michael, Helen, Todd, Anne, Todd, Jackie, Todd, Stacy, Tohfa, Mohamed, Tolson, Melanie, Tomas, Ana L, Tomasova, Natalia, Tomlin, Sharon, Tomlins, Simon, Tonna, Ivan, Topham, Kirsty, Topping, Mathew, Torabi, Parisa, Torok, M Estee, Toshner, Mark, Tousis, Ruhaif, Tovey, Peter, Towersey, Gareth, Townley, Jill, Tozer, Richard, Trafford, Myat T, Tranter, Helen, Travill, Christopher, Traynor, Sarah, Tridente, Ascanio, Triggs, Sanchia, Trim, Fiona, Trimmings, Alex, Trinick, Tom, Tripouki, Maria, Trivedi, Ashifa, Trodd, Dawn, Trotter, Amy, Trowsdale Stannard, Madeleine, Trudgill, Nigel, Trushell-Pottinger, Daniel, Truslove, Maria, Trussell, Shaun, Trussell, Tariq, Tsakiridou, Kyriaki, Tsang, Christine, Tsang, Peter, Tsilimpari, Kyriaki K, Tsinaslanidis, Georgios, Tso, Simon, Tucker, Sally, Tufail, Aisha, Tully, Redmond, Turbitt, Killian, Turel, Rezon, Turgut, Tolga, Turley, Claudia, Turnbull, Alison, Turner, Aine, Turner, Ash, Turner, Charlotte, Turner, Gail, Turner, Kate, Turner, Kelly, Turner, Lucy, Turner, Mark, Turner, Patricia, Turner, Sally, Turner, Samantha, Turner, Victoria, Turney, Sharon, Turvey, Jon, Twohey, Emma, Tyagi, Bhavya, Tyagi, Vedang, Tyer, Abigail, Tyler, Jayne, Tyler, Jennifer, Tyzack, Alison, Tzavaras, Petros, Uddin, Mohammad S, Uddin, Ruhama, Ul Hassan, Waqar, Ullah, Salamat, Ullah, Sanda, Umaipalan, Athavan, Umeadi, Judith, Umeh, Akudo, Umeojiako, Wilfred, Undrell, Lizzie, Unsworth, Adam, Uppal, Veerpal SU, Upson, Gerry, Uriel, Alison, Urruela, Sebastian, Uru, Hiromi, Usher, Miranda, Usher, Rebecca, Ustianowski, Andrew, Vaccari, Linda C, Vaidya, Abhay, Vainieri, Erika, Valecka, Bernardas, Valentine, Jennifer, Valeria, Balan, Vamplew, Luke, Vamvakiti, Ekaterini, Vamvakopoulos, Joannis, van de Venne, Maud, van der Meer, Alex, van der Stelt, Nora, Van Koutrik, Lynne, Vance-Daniel, Joseph, Vancheeswaran, Rama, Vandeyoon, Samuel I, Vankayalapati, Padma, Vansomeren, Chloe, Van't Hoff, William, Vara, Sejal, Varghese, Anu, Varghese, Maria, Varghese, Teena, Varney, William, Varnier, Giulia, Vasadi, Valeria, Vasu, Vimal, Vasudevan, Vasanthi, Vathenen, Ramu, Vatish, Manu, Vayalaman, Heloyes, Vaz, Christopher, Veale, Niki, Velan, Bar, Velankar, Swati, Velauthar, Luxmi, Veli, Neyme, Vella, Nicola, Velusamy, Anitha, Venables, Ian, Venditti, Mavi, Venkataramakrishnan, Ramya, Venn, Richard, Venn, Robert, Ventilacion, Lyn, Veres, Mark, Vergnano, Stefania, Verling, Will, Verma, Amit, Vernon, Britney, Vernon, Nathan, Vertue, Mark, Vethanayagam, Natalie, Veys, Lucy, Vidler, Jennifer, Vigni, Denise, Vijayaraghavan Nalini, Vinod W, Vilar, Enric, Vilimiene, Neringa, Villiers, Joseph, Vinay, Sylvia, Vinayakarao, Latha, Vincent, Rachel, Vincent, Rosie, Vincent Smith, Lisa, Virgilio, Emma, Virk, Abdullah M, Visentin, Elisa, Vithian, Karunakaran, Vuylsteke, Alain, Vyras, Eleftheria, Wach, Richard, Wadams, Beverley, Wadd, Susan, Waddington, Natalia, Wadsworth, Kirsten, Wafa, Syed EI, Wagstaff, Daniel, Wagstaff, Lynda, Wahab, Dalia, Wahbi, Zaroug, Wahdati, Khalilullah, Waidyanatha, Sawan, Wake, Rachel, Wakefield, Alice, Wakefield, Emma, Wakefield, Harry, Wakeford, William, Wakinshaw, Fiona, Walden, Andrew, Walding, Lorna, Walker, Claire, Walker, Ian, Walker, Kevin, Walker, Kim, Walker, Linda, Walker, Marie, Walker, Rachel, Walker, Susan, Wall, Elaine, Wallbutton, Rebecca, Wallen, Jessica, Wallendszus, Karl, Waller, Arabella, Waller, Michael, Waller, Rosemary, Wallis, Gabriel, Wallis, Louise, Walsh, Donna, Walsh, Elizabeth, Walshaw, Lani, Walter, Daniel, Walters, Holt, Walters, Jocelyn, Walton, Eileen, Walton, Maggie, Walton, Michael, Walton, Olivia, Walton, Susan, Wan, Mandy, Wan, Thin, Wands, Mary, Wane, Rachel, Wang, Frank, Wang, Nick, Wang, Ran, Warbrick, Deborah, Warburton, Samantha, Ward, Deborah, Ward, Emma, Ward, Katie, Ward, Luke, Ward, Rachael, Ward, Thomas, Warden, Scott A, Wardle, Steve, Wardy, Hassan, Wareham, Tobias, Waring, Scott, Warmington, Jenny, Warner, Ben, Warner, Christian, Warnock, Lewis, Warran, Sarah, Warren, Lisa, Warren, Yolanda, Warren-Miell, Hannah, Watchorn, Hazel J, Waterfall, Holly, Waters, Abby, Waters, Donald, Waterstone, Mark, Watkins, Catherine, Watkins, Catrin, Watkins, Eleanor, Watkins, Karen, Watkins, Lynn, Watson, Adam JR, Watson, Ekaterina, Watson, Eleanor, Watson, Paul, Watson, Robert, Watters, Malcolm, Watterson, Donna, Watts, Daniel, Watts, John, Watts, Merlin, Waugh, Victoria, Wayman, Emma, Wazir, Akhlaq, Weatherly, Nick, Webb, Hayley, Webb, Kathryn, Webb, Stephen, Webster, Ian, Webster, Tim, Wee, Ling, Weerasinghe, Thanuja, Weeratunga, Janaka, Weetman, Maria, Wei, Shuying, Weidi, Freshtah, Welch, Hugh, Welch, James, Welch, Leanne, Welch, Steven, Weller, Samantha, Wells, Claire, Wellstead, Susan, Welsh, Berni, Welsh, RIchard, Welters, Ingeborg, Welton, Rachael, Wentworth, Lauren, Wesseldine, Kate, West, Magdelena, West, Raha, West, Ruth, West, Sophie, Weston, Heather, Westwood, Alice, Wetherall, Bill, Wheeler, Helen, Whelband, Matthew, Whileman, Amanda, Whitbread, Jenny, White, Benjamin, White, Catherine, White, Christopher, White, Duncan, White, James, White, Jonathan, White, Katie, White, Marie, White, Nick, White, Sarah, White, Sonia, White, Tracey, Whitehead, Catherine, Whitehouse, Anne, Whitehouse, Claire, Whitehouse, Tony, Whiteley, Sophie, Whitlingum, Gabriel, Whittaker, Elizabeth, Whittam, Lindsay, Whittington, Ashley, Whittle, Helen, Wiafe, Eunice, Wiblin, Lou, Widdrington, John, Wieboldt, Jason, Wieringa, Hannah, Wiesender, Cornelia, Wiffen, Laura, Wight, Andrew, Wignall, Christopher, Wilcock, Danielle, Wilcock, Emma, Wilcox, Louise, Wild, Karen, Wild, Laura, Wild, Stephen, Wilde, Michael, Wilding, Peter, Wildsmith, Tracey, Wileman, Joe, Wiles, Joy, Wiles, Kate, Wilhelmsen, Elva, Wiliams, Thomas, Wilkin, David, Wilkins, Hannah, Wilkins, Joy, Wilkins, Suzanne, Wilkinson, Iain, Wilkinson, Lesley, Wilkinson, Nicola, Wilkinson, Sophia, Wilkinson, Susan, Wilkinson, Tim, Willetts, Sylvia, Williams, Alexandra, Williams, Alison, Williams, Angharad, Williams, Ava, Williams, Carl, Williams, Caroline V, Williams, Claire, Williams, Dewi, Williams, Felicity, Williams, Gail, Williams, Hannah, Williams, James, Williams, Jennie, Williams, John, Williams, Joseph JR, Williams, Karen, Williams, Kathryn, Williams, Marie, Williams, Matthew, Williams, Patricia, Williams, Penny, Williams, Samson, Williams, Sarah, Williams, Sophie, Williams, Tamanna, Williamson, Annie, Williamson, Cath, Williamson, Catherine, Williamson, Dawn, Williamson, James D, Willis, Elizabeth, Willis, Emily, Willis, Heather, Willis, Herika, Willis, Joanna, Wills, Louise, Willsher, Lucy, Willson, Francesca, Wilson, Alison, Wilson, Andrea, Wilson, Antoinette, Wilson, Debbie, Wilson, James, Wilson, Kate, Wilson, Lucinda, Wilson, Mark, Wilson, Toni, Wilson, Tim, Win, Marlar, Win, Tin T, Winckworth, Lucinda, Winder, Laura, Winder, Piers, Window, Nicola, Winn, Simon, Winpenny, Carmen, Winslow, Helen, Winstanley, Martin, Winter, Helen, Winter, Jonathan, Winter-Goodwin, Barbara, Wisdom, Stephen, Wiselka, Martin, Wiseman, Sophie, Wishart, Steven, Witele, Eric, Withers, Nicholas, Wittes, Janet, Wixted, Donna, Wolff, Nicola, Wolffsohn, Kirsten, Wolf-Roberts, Rebecca, Wolodimeroff, Elena, Wong, Chi-Hung, Wong, Edwin, Wong, Jessica SY, Wong, Kit Y, Wong, Nick, Wong, Sam, Wood, Caroline, Wood, Dianne, Wood, Fiona, Wood, Hannah, Wood, Jennifer, Wood, Joe, Wood, Lisa, Wood, Louise, Wood, Michelle, Wood, Stephen, Wood, Tracy, Woodall, Katharine, Woodfield, Rebecca, Woodford, Christopher, Woodford, Jill, Woodhead, Louise, Woodhead, Timothy, Woodland, Philip, Woodman, Marc, Woods, Jane, Woods, Katherine, Woods, Sarah, Woodward, Elizabeth, Woodward, Zoe, Woolcock, Megan, Wooldridge, Gemma, Woolf, Rebecca, Woollard, Chris, Woollen, Louisa, Woolley, Emma, Woolley, Jade, Woosey, Daniel, Wootton, Dan, Wootton, Joanne, Worton, Stephy, Wraight, Jonathan, Wren, Lynn, Wrey Brown, Caroline, Wright, Demi, Wright, Francesca, Wright, Imogen, Wright, Lianne, Wright, Rachel, Wroe, Caroline, Wu, Henry, Wu, Peishan, Wu, Pensee, Wubetu, Johnathan, Wulandari, Retno, Wyness, Kim, Wyn-Griffiths, Frederick, Wynter, Inez, Xavier, Bindhu, Xia, Zhongyang, Yakubi, Masseh, Yan, May, Yanney, Michael, Yasmin, Salima, Yates, Bryan, Yates, David, Yates, Edward, Yates, Helen, Yates, Mark, Yearwood Martin, Charlotte, Yein, Khin, Yellon, Robert, Yelnoorkar, Fiona, Yew, Peter, Yip, Kawai, Ylquimiche Melly, Laura, Ynter, Inez, Yong, Cissy, Yorke, Jemma, Younes Ibrahim, Abdel, Young, Gail, Young, Louise, Youssouf, Sajeda, Yousuf, Ahmed, Yu, Chrissie, Yung, Bernard, Yusef, Daniel, Zafar, Anna-Sophia, Zagalo, Silvia, Zaher, Su, Zaki, Kareem, Zakir, Nabhan, Zalewska, Kasia, Zamalloa, Ane, Zaman, Mohsin, Zaman, Shakir, Zamikula, Julie, Zammit, Louise, Zammit-Mangion, Marie, Zdanaviciene, Ausra, Zebracki, Esther, Zehnder, Daniel, Zeidan, Lisa, Zhao, Xiaobei, Zheng, Dongling, Zhixin, Jane, Zhu, Doreen, Zia, Madiha, Zibdeh, Omar, Zill-E-Huma, Rabia, Zin, Ei T, Zinyemba, Vivian, Zipitis, Christos, Zmierczak, Arkadiusz, Zubir, Azam, Zuhra, Naz, Zulaikha, Rasha, Zullo, Carol, and Zuriaga-Alvaro, Ana
Abstract: Azithromycin has been proposed as a treatment for COVID-19 on the basis of its immunomodulatory actions. We aimed to evaluate the safety and efficacy of azithromycin in patients admitted to hospital with COVID-19.
Published: 2021
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208. Real time model predictive idle speed control of ultra-lean burn engines: experimental results

Author: Sharma, R., Dennis, P., Manzie, C., Nesić, D., and Brear, M.J.
Abstract: Idle speed control of ultra-lean burn engines continues to be a major focus of automotive engineers owing to the benefits offered in terms of fuel economy and emissions reduction. This paper applies a recently proposed linear time varying model predictive approach for the idle speed control of ultra-lean burn internal combustion engines. Unlike conventional gasoline engines, the approach uses fuel flow as the primary control variable to compensate for sudden fluctuations in engine load resulting in a fuel assisted idle speed control strategy. Simultaneously, the spark angle is maintained at a value so as to yield maximum brake torque while the emissions are reduced to negligibly low levels by constraining the engine operation to ultra-lean burn mode. The technique is demonstrated on an inline prototype 4-litre, 6-cylinder hydrogen fuelled internal combustion engine.
Published: 2011
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209. Building organisational resilience through a designed-in security management approach

Author: Trim, Peter, Jones, Nigel, and Brear, Kevin
Abstract: The body of security knowledge can be defined as varied, wide-ranging and somewhat fragmented. There have been attempts to link aspects of corporate security with aspects of national security; however, the public–private sector issue and partnership development have not always been easily addressed or resolved. Arguably, the failing state body of knowledge is being approached from either an economic or political science perspective, and because of this, key threats facing individual organisations, such as insider crime, and emerging entrepreneurship and crime, are not always addressed appropriately. As such, senior management need to reduce their organisations' vulnerability by reappraising their risk level and placing security within a more holistic context. By viewing security as a core value, it should be possible for managers to adopt a new approach to defining their risk management strategy and getting the various functions of the organisation to embrace security and intelligence activities. In order to be effective, security needs to be designed into the organisation's structure and operating system. Where this is the case, a security culture is likely to emerge that provides both the organisation and partner organisations with a fresh vision for dealing with business continuity issues.
Published: 2009

210. An experimental study of the spray from an air-assisted direct fuel injector

Author: Jin, S H, Brear, M, Watson, H, and Brewster, S
Abstract: The transient behaviour of the fuel spray from an air-assisted direct-injection spark ignition (DISI) fuel injector has been investigated experimentally in a constant-volume chamber. As the chamber and injection pressures were varied, ensemble-averaged planar images of the laser-induced fluorescence (LIF) and Mie scattering from the spray were obtained to measure the Sauter mean diameter (SMD) using the laser sheet drop-sizing (LSD) technique. The root mean square (r.m.s.) SMD was also calculated by combination of the r.m.s. LIF and r.m.s. Mie scattering signals. The effect of the injection and chamber pressures and the ambient air density on the SMD, spray tip penetration, and dispersion of the air-assisted fuel injector are determined. In keeping with recent numerical studies by the group, vortex structures appear to be shed from the injector tip in back-illuminated images, indicating that the air and liquid motion are strongly coupled. These results also show that the spray penetration and SMD vary significantly with injection and chamber density, and scalings of the spray's overall SMD and penetration are proposed that achieve reasonable clustering in the experimental results.
Published: 2008
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211. Assessing the value of online affiliate marketing in the UK financial services industry

Author: Brear, David and Barnes, Stuart
Abstract: This research attempts to understand affiliate marketing success and application within three financial services markets. The results of both quantitative and qualitative research reveal a distinct pattern of success and failure in the markets researched. These results were used in order to create a list of attributes by which the 'suitability' of a market for affiliate marketing can be evaluated. We conclude that the process of affiliate marketing needs to be implemented in a much more contingent manner, catered to the market attributes and variances exhibited.
Published: 2008

212. The Correlation of Student Performance in Preclinical and Clinical Prosthodontic Assessments

Author: Curtis, Donald A., Lind, Samuel L., Brear, Sheila, and Finzen, Frederick C.
Abstract: Tracking student performance in preclinical and clinical courses can be helpful in developing and refining a curriculum. Our objective was to correlate student performance on three fixed prosthodontic examinations taken by eighty junior dental students. Examinations included a knowledge‐based objective structured clinical examination (OSCE), a manual skills exercise completed on a typodont (Typodont), and a competency casting exam (Casting CE) on a patient. Multiple regression analysis indicated that the OSCE and Typodont exam scores, as independent variables, were not statistically significant predictors (P=0.07; P=0.87, respectively) of Casting CE exam performance, which was the dependent variable. Correlations were weak for the OSCE (r=0.21) and nearly nonexistent for the Typodont exam(r=0.03) when compared to the Casting CE. Our results indicate a weak correlation between an OSCE‐based knowledge exam measuring students’ knowledge of critical errors in preparations and castings and a competency exam involving the preparation of a full veneer crown. Results also indicate virtually no correlation between a typodont preparation examination designed to provide a measure of students’ clinical skill and a clinical competency exam involving the preparation of a full crown.
Published: 2007
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213. Establishment of Freezing Model for Reactor Safety Analysis

Author: KAMIYAMA, Kenji, BREAR, DavidJ., TOBITA, Yoshiharu, and KONDO, Satoru
Abstract: A mechanistic simulation of molten core-material relocation is required to reasonably assess consequences of postulated core disruptive accidents (CDAs) in fast reactors (FRs). The dynamics of molten core-material freezing when it is driven into the channels surrounding the core region plays an important role since this affects fuel removal from the core region. Therefore, a mechanistic model for freezing behavior was developed and introduced into the FR safety analysis code, SIMMER-III, in this study. Based on the micro-physics of crystallization, two key assumptions, supercooling of melt in the vicinity of the wall and melt-wall contact resistance due to imperfect contact, were introduced. As a result, encouraging agreement both with measured melt-penetration lengths and freezing modes of UO2and metals was obtained. Furthermore, in order to reinforce the developed model, a semi-empirical correlation to predict the supercooling temperature was found. The developed model with the new correlation reproduced both stainless steel freezing and alumina freezing.
Published: 2006
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214. Evaluating Telemedicine: Lessons and Challenges

Author: Brear, Michelle
Abstract: Telemedicine applications have been rapidly implemented since the early 1990s and are now in use in a wide range of healthcare settings. There is, however, limited evidence of clinical benefits resulting from their use. This paper describes the design and implementation of a multi-method evaluation of an emergency telemedicine application's clinical impact. In particular, the challenges faced and lessons learnt regarding the development of a suitable methodology and collection of health information from a variety of sources are discussed. In order to understand the application's clinical impact it was necessary to use different types of data from multiple sources, and to interpret the results from each enquiry in relation to results from the others.
Published: 2006
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215. Evaluating community participation in a Healthy Islands setting: towards evidence-based decision making

Author: Brear, M., Powis, B., O'Leary, Z., and Davidson, D.
Abstract: The Healthy Island concept has given rise to many health promotion initiatives throughout the Pacific, including the use of ‘settings’ to reorient environmental health (EH) practice. The apparent success of such approaches has seen a major shift in the practice of EH practitioners, yet formal evaluation of either the process or outcomes is rarely undertaken. This paper examines the issue of community participation in one such settings project through the development, distribution, and analysis of a questionnaire distributed to 200 residents in the Makoi district of Fiji. The questionnaire explored processes and outcomes related to the implementation of a Healthy Islands settings project in the Makoi community and assessed whether a core stated goal of the Makoi Healthy Island project, namely community-wide participation, had been met. Results/Conclusions: The study found that awareness of health promotion interventions was not evenly distributed across various sectors of the population and that community support structures were not being accessed by the full range of the target population. The use of the Methodist Church as a single entry point to the Makoi community in isolation from a possible range of entry points is a likely contributor in not allowing for the racial and cultural inclusion the project had aimed for. The study concludes with recommendations for entry into settings more likely to engage the full range of stakeholders and community members. This study highlights that engagement in health promotion initiatives is highly reliant on access strategies. It also suggests that goals relating to evidence-based decision-making can only be met if critical evaluative strategies are embedded in health promotion project planning from the inception.
Published: 2004
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216. Crack growth modelling and probabilistic life assessment of coke drums operating under fatigue conditions

Author: Church, J. M., Lim, L. B., Brear, J. M., Jarvis, P., Lant, R. P., and Middleton, C. J.
Published: 2001
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217. Life assessment of steam reformer radiant catalyst tubes - the use of damage front propagation methods

Author: Brear, J. M., Church, J. M., Humphrey, D. R., and Zanjani, M. S.
Published: 2001
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218. SIMMER-III applications to fuel-coolant interactions

Author: Morita, K., Kondo, S., Tobita, Y., and Brear, D.J.
Published: 1999
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219. Rationalisation of the Multiaxial Stress Rupture Behaviour of Components

Author: Church, J.M., Brear, J.M., and Humphrey, D.R.
Abstract: Not Available
Published: 1999
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220. Predicting the Creep Life and Failure Location of Weldments

Author: Brear, J.M., Fairman, A., Middleton, C.J., and Polding, L.
Abstract: Not Available
Published: 1999
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221. Management of Large Filtering Blebs with the Argon Laser

Author: Fink, Alan J., Boys-Smith, John W., and Brear, Russell
Abstract: Complications attributable to large conjunctival blebs after glaucoma filtering surgery range from annoying foreign-body sensation to devastating endophthalmitis. We used the argon laser to shrink large complicated blebs in four eyes of four patients who had previously undergone glaucoma filtering surgery. The eye is first anesthetized with a topical agent. The bleb surface is lightly abraded with a sterile cotton swab and then “painted” with a tissue-staining dye. Diffuse laser burns applied over the surface resulted in sufficient shrinkage to allow resolution of the respective symptoms or secondary complications in all four cases. The first two patients developed small leaks that we attribute to delivering laser burns to extremely thin areas of conjunctiva. In both cases the leaks gradually sealed over several weeks. None of the eyes developed increases in intraocular pressure or anterior segment inflammation. In each case, filtering capability was maintained.
Published: 1986
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222. The effects of ageing and changes in mineral content in degrading the toughness of human femora

Author: Currey, J. D., Brear, K., and Zioupos, P.
Published: 1996
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223. Conjunctival Biopsy in Sarcoidosis

Author: Karcioglu, Zeynel A. and Brear, Russell
Abstract: In a prospective study of systemic sarcoidosis, 28 patients underwent 55 conjunctival biopsies. The incidences of positive granulomatous lesions in proven and suspected sarcoidosis cases were 71.4% (ten of 14 patients) and 28.5% (four of 14 patients), respectively. Thus, random, bilateral conjunctival biopsies should be performed as soon as possible in all cases of presumed sarcoidosis.
Published: 1985
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224. Synthesis and antifungal activity of six benzylic diamines

Author: Brear, Kieron, Walters, Dale, and Robins, David
Abstract: Six benzylic diamines were synthesised and examined for antifungal activity. Four of the compounds, KB 2, KB 4, KB 5 and KB 6, reduced radial growth of the oat leaf stripe pathogen Pyrenophora avenae, the largest reduction obtained with 25 μM KB 4, which reduced radial growth by 47%. Surprisingly, these four amines had no effect against infection of barley seedlings with the powdery mildew fungus Erysiphe graminisf.sp. hordei. Instead, two different amines, KB 1 and KB 3, reduced powdery mildew infection on barley. The greatest reduction was obtained with 25 μM KB 3, which reduced mildew infection by 69%. All of the amines which exhibited antifungal or fungicidal properties perturbed polyamine formation as measured by the incorporation of labelled ornithine into polyamines.
Published: 1997
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225. An approach to the complexities of the Hindu tradition

Author: Brear, A. D.
Abstract: Of all the 'world religions' which find a place in the syllabus, none, perhaps, presents greater difficulties in the way of comprehension than the Hindu tradition. Quite apart from the dangers involved, as W. Cantwell Smith has pointed out, in the reduction of living traditions to conceptually-convenient, but static, categories, the anomalous character of this particular tradition is striking and well-known. After a clear statement of this anomalousness, Dr Sharpe goes on to give a provisional definition of Hinduism as 'the traditional socio-religious structure of India in so far as it rests on belief in the authority of certain ... scriptures, and is contained within the institution of caste.'1
Published: 1984
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226. The Development of a Direct Injection Diesel Combustion System for Low Noise, Emissions and Mechanical Loading

Author: Jane, P A H and Brear, F
Abstract: In recent years the whole climate of diesel engine development has changed with the advent of noise and emissions legislation combined with the demand for higher specific output.The conventional direct injection combustion chambers that have been used in the 1 litre/cylinder class of engine now present difficulties to the engineer in meeting these increasingly stringent demands.The development history of a novel combustion system, ‘Quadram’, is presented, leading up to its introduction into quantity production. Emphasis has been placed on achieving the legislative targets while retaining cost effective fuel injection equipment, in an intensely competitive market complicated by worldwide fuel quality variations.The ‘Quadram’ system is shown to display the key feature of achieving optimum performance with retarded injection timing, without any compromise to engine durability.
Published: 1989
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227. Interobserver variation in the chest radiograph component of the lung injury score

Author: BEARDS, S. C., JACKSON, A., HUNT, L., WOOD, A., FRERK, C. M., BREAR, G., EDWARDS, J. D., and NIGHTINGALE, P.
Abstract: The lung injury score is a semi‐quantitative system used in the definition and grading of the acute respiratory distress syndrome. It is composed of two, three or four equally weighted components. One component is derived from the chest radiograph, which may contribute up to 50% of the total score. A score of 1 is awarded for each quadrant on the chest radiograph which contains alveolar consolidation. We examined the interobserver variation between two anaesthetists, two radiologists and two critical care physicians who scored blindly 100 chest radiographs from patients with adult respiratory distress syndrome. There was very good agreement between the two radiologists in the total scores (kappa 0.97) and in individual scores in each of the 4 quadrants (kappa 0.97–1.0). The agreement between anaesthetists and radiologists was only fair for the total score (kappa 0.37–0.42), but moderate to good for individual quadrant scores (kappa 0.43–0.73). The agreement between the two anaesthetists was moderate for individual quadrant scores (kappa 0.44–0.60), but only fair for total score (kappa 0.34). There was poor agreement between the two critical care physicians for total score (kappa 0.05) and for individual quadrant scores (kappa 0.04–0.20). Agreement between the physicians and other observers was poor to fair for the total score (kappa 0.12–0.32) and poor to moderate for the individual quadrant scores (kappa 0.15–0.63). Both anaesthetists and physician 2 underestimated the overall chest scores (median scores 2, 3 and 1 respectively) in comparison to the radiologists (median scores 3.5). Physician 1 significantly overscored (median score 4). The chest radiograph component of the lung injury score can be consistently assessed by radiologists, but significant variations may be introduced when assessed by other clinicians. This has significant implications for the use of the lung injury score in studies of adult respiratory distress syndrome and other studies which incorporate radiographic appearances in the definition.
Published: 1995
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228. A Mechanistic Approach to Remanent Creep Life Assessment of Low Alloy Ferritic Components Based on Hardness Measurements

Author: Cane, B. J., Aplin, P. F., and Brear, J. M.
Abstract: Creep damage leading to failure in low alloy ferritic steels at service operating conditions results from: (i) structural coarsening leading to a continuous reduction in creep strength during exposure, and (ii) intergranular creep cavitation. A mechanistic model is presented for describing tertiary creep which accounts for both of these factors. By assuming a limiting creep ductility corresponding to a maximum cavitation potential a lower bound life predictive approach is given. The significant structural parameters are then the background solid solution strength, the interparticle spacing (λ) and the rate of increase of λ, although the long-term, creep-rupture strength is shown to be dictated largely by the latter. Consideration is given to the determination of these kinetics by means of hardness change measurements: good correlations are found with experimental data. A methodology for characterizing the remanent creep life of component material using hardness measurements and post-exposure aging is developed on this basis.
Published: 1985
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229. Purification and properties of L-glutaminase-L-asparaginase from Pseudomonas acidovorans

Author: Davidson, L, Brear, D R, Wingard, P, Hawkins, J, and Kitto, G B
Abstract: An enzyme that catalyzes the hydrolysis of both glutamine and asparagine has been purified to homogeneity from extracts of Pseudomonas acidovorans. The enzyme having a ratio of glutaminase to asparaginase of 1.45:1.0 can be purified by a relatively simple procedure and is stable upon storage. The glutaminase-asparaginase has a relatively high affinity for L-asparagine (Km=1.5 X 10(-5) M) and L-glutamine (Km=2.2 X 10(-5) M) and has a molecular weight of approximately 156,000 the subunit molecular weight being approximately 39,000. Injections of the enzyme produced only slight increases in the survival time of C3H/HE mice carrying the asparagine-requiring 6C2HED Gardner lymphoma and of white Swiss mice carrying the glutamine-requiring Ehrlich lymphoma.
Published: 1977
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230. Prospects of Reciprocating Engines and Fuels

Author: Brear, Michael J.
Published: 2019
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231. Safety, immunogenicity, and efficacy of a COVID-19 vaccine (NVX-CoV2373) co-administered with seasonal influenza vaccines: an exploratory substudy of a randomised, observer-blinded, placebo-controlled, phase 3 trial

Author: Toback, Seth, Galiza, Eva, Cosgrove, Catherine, Galloway, James, Goodman, Anna L, Swift, Pauline A, Rajaram, Sankarasubramanian, Graves-Jones, Alison, Edelman, Jonathan, Burns, Fiona, Minassian, Angela M, Cho, Iksung, Kumar, Lakshmi, Plested, Joyce S, Rivers, E Joy, Robertson, Andreana, Dubovsky, Filip, Glenn, Greg, Heath, Paul T, Soiza, Roy L., Brittain-Long, Robin, Scicluna, Chiara, Edwards, Carole, Mackay, Lynn, D'Allesandro, Mariella, Nicol, Amy, Norris, Karen, Mann, Sandra, Lawrence, Heather, Valentine, Ruth, Viljoen, Marianne Elizabeth, Pretswell, Carol H., Nicholls, Helen, Munsoor, Imrozia, Meyrick, Agnieszka, Kyriakidou, Christina, Iyengar, Shalini, Jamal, Arham, Richards, Nick, Price, Helen, Rowbotham, Bridie, Bird, Danielle, Smith, Karen, Littler, Olga, Fielding, Kirsty, Townsend-Rose, Anna, Miller, Karen, Davis, Jessica, Elliot-Garwood, Alison, Trottier, Lauren, Edwards, Paul, McFarland, Margaret, Osanlou, Orod, Longshaw, Laura, Stockport, Jane, Grundy, Lynne, Broad, Katharine Lucy, Regan, Karen, Storton, Kim, Ryan-Wakeling, Declan, Wilson, Brad, Munisamy, Malathy, Wright, John, Shenoy, Anil, English, Beverley, Brear, Lucy, Cicconi, Paola, Boffito, Marta, Milinkovic, Ana, Byrne, Ruth, Movahedi, Roya, Housman, Rosalie, Kara, Naveed, Brown, Ellen, Cipriani, Andrea, Attenburrow, Mary-Jane, Smith, Katharine A., Packham, Jonathan, Sparrow, Geoff, Smith, Richard, Rosier, Josephine M., Saja, Khalid, Nago, Nyasha, Camilleri, Brian, Immanuel, Anita, Hamblin, Mike, Osagie, Rawlings, Mohan, Mahalakshmi, Floyd, Hilary, Goddard, Suzanne, Mutgi, Sanjay, Evans, John, McKeon, Sean, Vilimiene, Neringa, Chicano, Rosavic, Hayre, Rachel, Pandaan, Alice, Henshall, Catherine, Serrano, Sonia, Mazzella, Andrea, Rajeswaran, Thurkka, Mathew, Moncy, Bisnauthsing, Karen, Bremner, Laura, Fok, Henry, Morselli, Franca, Cinardo, Paola, Merrick, Blair, Sowole, Lucy, Broadhead, Samantha, Palmer, Natalie, Cordle, Jessica, Goldsmith, Jaimie Wilson, Cooney, Enya, Jackson, Beth, Jayatilleke, Thilina, Cheng, Zelda, Helliwell, Toby, Chudyk, Adrian, Giemza, Rafaela, Villajin, John Lord, Yogo, Noah, Makanju, Esther, Dulawan, Pearl, Nagra, Deepak, Buazon, April, Russell, Alice, Bird, Georgie, Heer, Amardeep, Sarmiento, Rex, Sanghera, Balraj, Mullin, Melanie, Champion, Adam, Bevan, Aisling, Iqbal, Kinzah, Johnson, Alshia, Clark, Rebecca, Shaw, Sarah, Shaw, Steven, Chalk, Amanda, Lovatt, Martin, Lillicrap, Caroline, Parker, Angela, Hansel, Jan, Wong, Zhi, Gan, Galvin, Tuma, Eyad, Minton, Jane, Murira, Jennifer, Saman, Razan, Hall, Alistair, Holliday, Kyra, Khan, Zara, Calderwood, James, Twigg, George, Baker, Helena, Corrigan, Julie, Houseman, Katy, Raguvanshi, Subhra, Heining, Dominic, Weddell, Jake, Glaves, Liz, Thompson, Kim, Davies, Francis, Lambley Burke, Ruth, Thomson, Emma C., Saralaya, Dinesh, Berry, Lisa, Hopewell, Nancy, Gerdes, Leigh, Pacurar, Mihaela, Faust, Saul N., Turner, Jeremy, Jeanes, Christopher, Cooper, Adele, Keshet-Price, Jocelyn, Coke, Lou, Cambell-Kelly, Melissa, Dhatariya, Ketan, Williams, Claire, Marks, Georgina, Sudbury, James, Rodolico, Lisa, Bradley, Judy, Carr, Sharon, Martin, Roisin, Madden, Angelina, Biagioni, Paul, McKenna, Sonia, Clinton, Alison, O'Kane, Maurice, Carter, Justin, Dewhurst, Matthew, Wetherill, Bill, Hoggarth, Thandiwe, Collins, Katrina Lennon, Chowdhury, Marie, Nathoo, Adil, Heinen, Anna, MacDonald, Orla, Hurducas, Claudia, Cifuentes, Liliana, Gill, Harjeevan, Gibson, Andy, West, Raha, Ewing, Jane, Blacow, Rachel, Haughney, John, MacDonald, Jonathan, Seenan, John Paul, Webb, Stewart, O'Leary, Colin, Muir, Scott, White, Beth, Ritchie, Neil, McAuley, Daniel F., Stewart, Jonathan, D'Alessandro, Mariella, Lakeman, Nicki, Purandare, Laura, Browne, Duncan, Tucker, David, Luck, Peter, Everden, Angharad, Trembath, Lisa, Visick, Michael, Morley, Nick, Reid, Laura, Chenoweth, Helen, Maclean, Kirsty, Sheridan, Ray P., Burden, Tom, Lunt, Craig Francis, Todd, Shirley, Estcourt, Stephanie, Pearce, Jasmine Marie, Wilkins, Suzanne, Love-Rouse, Cathryn, Torok-Pollok, Eva, Youle, Mike, Madge, Sara, Solomon, Danielle, Nandani, Aarti, North, Janet M., Hemat, Nargis, Newport, Rachel, Kalra, Philip A., Chukwu, Chukwuma, Wickens, Olivia, O'Loughlin, Vikki, Mistry, Hema, Harrison, Louise, Oliver, Robert, Peers, Anne-Marie, Zadik, Jess, Doyle, Katie, Chadwick, David R., Colling, Kerry, Wroe, Caroline, Branch, Marie, Chilvers, Alison, Essex, Sarah, Stone, Mark, San Francisco Ramos, Alberto, Beales, Emily, Bird, Olivia, Danos, Zsofia, Fofie, Hazel, Hultin, Cecilia, Ikram, Sabina, Mabesa, Fran, Mescall, Aoife, Pereira, Josyanne, Pearce, Jennifer, Sutton, Natalina, Snashall, Emma, Baxter, David Neil, Bennett, Sara, Suggitt, Debbie, Hughes, Kerry, Woodyatt, Wiesia, Beacon, Lynsey, Kent, Alissa, Cooper, Chris, Rudic, Milan, Tunstall, Simon, Jackson, Matthew, Hombersley, Claire, Moore, Patrick, Cutts, Rebecca, Higham, Andrew, Bukhari, Marwan, Elnaggar, Mohamed, Glover, Michelle, Richardson, Fiona, Dent, Alexandra, Mirza, Shahzeb, Ark, Rajiv, Han, Jennie, Hope, Suzy V., Mitchelmore, Philip J., Osanlou, Rostam, Freedman, Andrew, Cooper, Alison, Burton, Katherine, Katechia, Kashyap, Barrett, Michael, Salkeld, Jo, Hill, Natalie, Lee, Nathaniel, Perkins, Jon, and Fox, Polly
Abstract: The safety and immunogenicity profile of COVID-19 vaccines when administered concomitantly with seasonal influenza vaccines have not yet been reported. We therefore aimed to report the results of a substudy within a phase 3 UK trial, by evaluating the safety, immunogenicity, and efficacy of NVX-CoV2373 when co-administered with licensed seasonal influenza vaccines.
Published: 2021
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232. The synthesis and characterisation of ultra-violet light polymerisable azo dyes

Author: Brear, P., primary, Guthrie, J.T., additional, and Abdel-Hay, F.I., additional
Published: 1982
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233. Book Review

Author: Beachley Brear, Holly
Abstract: Dressing Up Debutantes: Pageantry and Glitz in Texas. Michaele Thurgood Haynes. Oxford:Berg. 1998. 180 pp, illus.
Published: 1999
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234. Epidural analgesia following cholecystectomy

Author: Addison, N V, Brear, F A, Budd, K, and Whittaker, M
Abstract: In a prospective study of 50 patients undergoing cholecystectomy epidural analgesia was found to be more effective than pethidine in achieving adequate postoperative analgesia. Pain was assessed using the visual linear analogue. In patients receiving epidural analgesia there was a 16 per cent reduction in the incidence of postoperative pulmonary infection compared with the control group. The small but significant number of complications arising and the time involved during anaesthesia may preclude the method from wider adoption, but it is suggested that epidural analgesia should be considered in high risk patients.
Published: 1974
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235. Rise in intracranial pressure with intravenous adenosine

Author: Clarke, K.W., Brear, S.G., and Hanley, S.P.
Published: 1992
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236. ChemInform Abstract: Aqueous Methods for the Preparation of 5′‐Substituted Guanosine Derivatives.

Author: Brear, Paul, Freeman, Gemma R., Shankey, Mark C., Trmcic, Milena, and Hodgson, David R. W.
Abstract: ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Published: 2010
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237. Perianal sepsis: drainage and fistulotomy or drainage only?

Author: Gya, D., Fethers, J., ley, K. Brear, and Jansz, A.
Published: 1989
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238. Dependence of mechanical properties on fibre angle in narwhal tusk, a highly oriented biological composite

Author: Currey, J. D., Brear, K., and Zioupos, P.
Published: 1994
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239. Early cytokine response to multiple injury

Author: Foex, B. A., Lamb, W. R., Roberts, T. E., and Brear, S. G.
Published: 1993
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240. Effect of formaldehyde fixation on some mechanical properties of bovine bone

Author: Currey, J. D., Brear, K., Zioupos, P., and Reilly, G. C.
Published: 1995
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241. Mitral Valve Prolapse: An Assessment of Clinical Features, Associated Conditions and Prognosis

Author: BETON, D. C., BREAR, S. G., EDWARDS, J. D., and LEONARD, J. C.
Abstract: One hundred and eighty-two patients (100 females, 82 males) with mitral valve prolapse (MVP) confirmed by echocardiography are described. Their ages range from 12 to 87 years (mean 48 years). The symptoms of breathlessness, pain in the chest and palpitations were analysed. They were associated with left ventricular failure, co-existing ischaemic heart disease and arrhythmias in some, but in a proportion the symptoms were thought to be due to psychoneurosis. Seventy-two patients (40 per cent) were referred because of complications of MVP. In 67 patients (37 per cent) the condition was discovered by chance and in 43 patients (24 per cent) neurotic symptoms had led to referral to hospital. A systolic click was heard in 117 patients (54 per cent); 41 patients (23 per cent) had a late systolic murmur and 30 patients (16 per cent) had a pansystolic murmur. The incidence of murmurs rose with increasing age, and pansystolic murmurs were more frequent in males. Thirty-two patients (18 per cent) had neither a click nor a murmur. Twenty-four patients (13 per cent) had associated supraventricular tachycardia and 22 (12 per cent) atrial fibrillation. Twelve patients (7 per cent) had severe mitral incompetence and eight (4 per cent) developed bacterial endocarditis. Only three patients had symptoms suggesting cerebral ischaemia. Twelve patients (7 per cent) had associated aortic incompetence. Twenty-two patients had had an inguinal hernia, the incidence in males over 50 being 26 per cent. Twenty-six patients (14 per cent) had non-specific T wave changes in the electrocardiogram. Echocardiography showed that 112 patients (62 per cent) had mid-systolic buckling of the posterior leaflet and 70 patients (38 per cent) had holosystolic prolapse. In view of the high incidence of complications it is felt that the long-term prognosis not as good as has been generally believed.
Published: 1983

242. Rapid discovery of monoclonal antibodies by microfluidics-enabled FACS of single pathogen-specific antibody-secreting cells.

Author: Fischer K, Lulla A, So TY, Pereyra-Gerber P, Raybould MIJ, Kohler TN, Yam-Puc JC, Kaminski TS, Hughes R, Pyeatt GL, Leiss-Maier F, Brear P, Matheson NJ, Deane CM, Hyvönen M, Thaventhiran JED, and Hollfelder F
Abstract: Monoclonal antibodies are increasingly used to prevent and treat viral infections and are pivotal in pandemic response efforts. Antibody-secreting cells (ASCs; plasma cells and plasmablasts) are an excellent source of high-affinity antibodies with therapeutic potential. Current methods to study antigen-specific ASCs either have low throughput, require expensive and labor-intensive screening or are technically demanding and therefore not widely accessible. Here we present a straightforward technology for the rapid discovery of monoclonal antibodies from ASCs. Our approach combines microfluidic encapsulation of single cells into an antibody capture hydrogel with antigen bait sorting by conventional flow cytometry. With our technology, we screened millions of mouse and human ASCs and obtained monoclonal antibodies against severe acute respiratory syndrome coronavirus 2 with high affinity (<1 pM) and neutralizing capacity (<100 ng ml -1 ) in 2 weeks with a high hit rate (>85% of characterized antibodies bound the target). By facilitating access to the underexplored ASC compartment, the approach enables efficient antibody discovery and immunological studies into the generation of protective antibodies., (© 2024. The Author(s).)
Published: 2024
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243. Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit SARS-CoV-2.

Author: Gaynor KU, Vaysburd M, Harman MAJ, Albecka A, Jeffrey P, Beswick P, Papa G, Chen L, Mallery D, McGuinness B, Van Rietschoten K, Stanway S, Brear P, Lulla A, Ciazynska K, Chang VT, Sharp J, Neary M, Box H, Herriott J, Kijak E, Tatham L, Bentley EG, Sharma P, Kirby A, Han X, Stewart JP, Owen A, Briggs JAG, Hyvönen M, Skynner MJ, and James LC
Subjects: Male, Animals, Cricetinae, Mice, Antiviral Agents pharmacology, Peptides pharmacology, Antibodies, Mesocricetus, Mice, Transgenic, Spike Glycoprotein, Coronavirus genetics, SARS-CoV-2, COVID-19
Abstract: COVID-19 has stimulated the rapid development of new antibody and small molecule therapeutics to inhibit SARS-CoV-2 infection. Here we describe a third antiviral modality that combines the drug-like advantages of both. Bicycles are entropically constrained peptides stabilized by a central chemical scaffold into a bi-cyclic structure. Rapid screening of diverse bacteriophage libraries against SARS-CoV-2 Spike yielded unique Bicycle binders across the entire protein. Exploiting Bicycles' inherent chemical combinability, we converted early micromolar hits into nanomolar viral inhibitors through simple multimerization. We also show how combining Bicycles against different epitopes into a single biparatopic agent allows Spike from diverse variants of concern (VoC) to be targeted (Alpha, Beta, Delta and Omicron). Finally, we demonstrate in both male hACE2-transgenic mice and Syrian golden hamsters that both multimerized and biparatopic Bicycles reduce viraemia and prevent host inflammation. These results introduce Bicycles as a potential antiviral modality to tackle new and rapidly evolving viruses., (© 2023. The Author(s).)
Published: 2023
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244. Catabolite repression control protein antagonist, a novel player in Pseudomonas aeruginosa carbon catabolite repression control.

Author: Sonnleitner E, Bassani F, Cianciulli Sesso A, Brear P, Lilic B, Davidovski L, Resch A, Luisi BF, Moll I, and Bläsi U
Abstract: In the opportunistic human pathogen Pseudomonas aeruginosa ( Pae ), c arbon c atabolite r epression (CCR) orchestrates the hierarchical utilization of N and C sources, and impacts virulence, antibiotic resistance and biofilm development. During CCR, the RNA chaperone Hfq and the c atabolite r epression c ontrol protein Crc form assemblies on target mRNAs that impede translation of proteins involved in uptake and catabolism of less preferred C sources. After exhaustion of the preferred C-source, translational repression of target genes is relieved by the regulatory RNA CrcZ, which binds to and acts as a decoy for Hfq. Here, we asked whether Crc action can be modulated to relieve CCR after exhaustion of a preferred carbon source. As Crc does not bind to RNA per se , we endeavored to identify an interacting protein. In vivo co-purification studies, co-immunoprecipitation and biophysical assays revealed that Crc binds to Pae strain O1 protein PA1677. Our structural studies support bioinformatics analyzes showing that PA1677 belongs to the isochorismatase-like superfamily. Ectopic expression of PA 1677 resulted in de-repression of Hfq/Crc controlled target genes, while in the absence of the protein, an extended lag phase is observed during diauxic growth on a preferred and a non-preferred carbon source. This observations indicate that PA1677 acts as an antagonist of Crc that favors synthesis of proteins required to metabolize non-preferred carbon sources. We present a working model wherein PA1677 diminishes the formation of productive Hfq/Crc repressive complexes on target mRNAs by titrating Crc. Accordingly, we propose the name CrcA ( c atabolite r epression c ontrol protein a ntagonist) for PA1677., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Sonnleitner, Bassani, Cianciulli-Sesso, Brear, Lilic, Davidovski, Resch, Luisi, Moll and Bläsi.)
Published: 2023
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245. Tuning liver pyruvate kinase activity up or down with a new class of allosteric modulators.

Author: Nain-Perez A, Nilsson O, Lulla A, Håversen L, Brear P, Liljenberg S, Hyvönen M, Borén J, and Grøtli M
Subjects: Hepatocytes metabolism, Cell Line, Lipogenesis, Pyruvate Kinase metabolism, Liver metabolism
Abstract: The liver isoform of pyruvate kinase (PKL) has gained interest due to its potential capacity to regulate fatty acid synthesis involved in the progression of non-alcoholic fatty liver disease (NAFLD). Here we describe a novel series of PKL modulators that can either activate or inhibit the enzyme allosterically, from a cryptic site at the interface of two protomers in the tetrameric enzyme. Starting from urolithin D, we designed and synthesised 42 new compounds. The effect of these compounds on PKL enzymatic activity was assessed after incubation with cell lysates obtained from a liver cell line. Pronounced activation of PKL activity, up to 3.8-fold, was observed for several compounds at 10 μM, while other compounds were prominent PKL inhibitors reducing its activity to 81% at best. A structure-activity relationship identified linear-shaped sulfone-sulfonamides as activators and non-linear compounds as inhibitors. Crystal structures revealed the conformations of these modulators, which were used as a reference for designing new modulators., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)
Published: 2023
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246. Systems-Wide Dissection of Organic Acid Assimilation in Pseudomonas aeruginosa Reveals a Novel Path To Underground Metabolism.

Author: Dolan SK, Wijaya A, Kohlstedt M, Gläser L, Brear P, Silva-Rocha R, Wittmann C, and Welch M
Subjects: Humans, Citrate (si)-Synthase genetics, Citrate (si)-Synthase metabolism, Propionates metabolism, Kinetics, Transcription Factors, Pseudomonas aeruginosa metabolism, Pseudomonas Infections microbiology
Abstract: The human pathogen Pseudomonas aeruginosa (Pa) is one of the most frequent and severe causes of nosocomial infection. This organism is also a major cause of airway infections in people with cystic fibrosis (CF). Pa is known to have a remarkable metabolic plasticity, allowing it to thrive under diverse environmental conditions and ecological niches; yet, little is known about the central metabolic pathways that sustain its growth during infection or precisely how these pathways operate. In this work, we used a combination of 'omics approaches (transcriptomics, proteomics, metabolomics, and 13 C-fluxomics) and reverse genetics to provide systems-level insight into how the infection-relevant organic acids succinate and propionate are metabolized by Pa. Moreover, through structural and kinetic analysis of the 2-methylcitrate synthase (2-MCS; PrpC) and its paralogue citrate (CIT) synthase (GltA), we show how these two crucial enzymatic steps are interconnected in Pa organic acid assimilation. We found that Pa can rapidly adapt to the loss of GltA function by acquiring mutations in a transcriptional repressor, which then derepresses prpC expression. Our findings provide a clear example of how "underground metabolism," facilitated by enzyme substrate promiscuity, "rewires" Pa metabolism, allowing it to overcome the loss of a crucial enzyme. This pathogen-specific knowledge is critical for the advancement of a model-driven framework to target bacterial central metabolism. IMPORTANCE Pseudomonas aeruginosa is an opportunistic human pathogen that, due to its unrivalled resistance to antibiotics, ubiquity in the built environment, and aggressiveness in infection scenarios, has acquired the somewhat dubious accolade of being designated a "critical priority pathogen" by the WHO. In this work, we uncover the pathways and mechanisms used by P. aeruginosa to grow on a substrate that is abundant at many infection sites: propionate. We found that if the organism is prevented from metabolizing propionate, the substrate turns from being a convenient nutrient source into a potent poison, preventing bacterial growth. We further show that one of the enzymes involved in these reactions, 2-methylcitrate synthase (PrpC), is promiscuous and can moonlight for another essential enzyme in the cell (citrate synthase). Indeed, mutations that abolish citrate synthase activity (which would normally prevent the cell from growing) can be readily overcome if the cell acquires additional mutations that increase the expression of PrpC. This is a nice example of the evolutionary utility of so-called "underground metabolism."
Published: 2022
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247. Crystal structure of the Rho-associated coiled-coil kinase 2 inhibitor belumosudil bound to CK2α.

Author: Brear P and Hyvönen M
Subjects: Acetamides, Adenosine Triphosphate, Crystallography, X-Ray, Humans, COVID-19, Casein Kinase II metabolism, rho-Associated Kinases genetics
Abstract: The small molecule belumosudil was initially identified as a selective inhibitor of Rho-associated coiled-coil kinase 2 (ROCK2) and has recently been approved for the treatment of graft-versus-host disease. However, recent studies have shown that many of the phenotypes displayed upon treatment with belumosudil were due to CK2α inhibition. CK2α is in itself a very promising therapeutic target for a range of conditions and has recently been put forward as a potential treatment for COVID-19. Belumosudil presents a promising starting point for the development of future CK2α inhibitors as it provides a safe, potent and orally bioavailable scaffold. Therefore, several of the major hurdles in drug development have already been overcome. Here, the crystal structure of belumosudil bound to the ATP site of CK2α is presented. This crystal structure combined with modelling studies further elucidates how belumosudil could be developed into a selective and potent CK2α or ROCK2 inhibitor., (open access.)
Published: 2022
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248. A fragment-based approach leading to the discovery of inhibitors of CK2α with a novel mechanism of action.

Author: Brear P, De Fusco C, Atkinson EL, Iegre J, Francis-Newton NJ, Venkitaraman AR, Hyvönen M, and Spring DR
Abstract: CK2 is a ubiquitous protein kinase with an anti-apoptotic role and is found to be overexpressed in multiple cancer types. To this end, the inhibition of CK2 is of great interest with regard to the development of novel anti-cancer therapeutics. ATP-site inhibition of CK2 is possible; however, this typically results in poor selectivity due to the highly conserved nature of the catalytic site amongst kinases. An alternative methodology for the modulation of CK2 activity is through allosteric inhibition. The recently identified αD site represents a promising binding site for allosteric inhibition of CK2α. The work presented herein describes the development of a series of CK2α allosteric inhibitors through iterative cycles of X-ray crystallography and enzymatic assays, in addition to both fragment growing and fragment merging design strategies. The lead fragment developed, fragment 8, exhibits a high ligand efficiency, displays no drop off in activity between enzymatic and cellular assays, and successfully engages CK2α in cells. Furthermore, X-ray crystallographic analysis provided indications towards a novel mechanism of allosteric inhibition through αD site binding. Fragments described in this paper therefore represent promising starting points for the development of highly selective allosteric CK2 inhibitors., Competing Interests: There are no conflicts to declare., (This journal is © The Royal Society of Chemistry.)
Published: 2022
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249. Anthraquinone derivatives as ADP-competitive inhibitors of liver pyruvate kinase.

Author: Nain-Perez A, Foller Füchtbauer A, Håversen L, Lulla A, Gao C, Matic J, Monjas L, Rodríguez A, Brear P, Kim W, Hyvönen M, Borén J, Mardinoglu A, Uhlen M, and Grøtli M
Subjects: Adenosine Diphosphate pharmacology, Anthraquinones pharmacology, Humans, Liver metabolism, Non-alcoholic Fatty Liver Disease, Pyruvate Kinase metabolism
Abstract: Liver pyruvate kinase (PKL) is a major regulator of metabolic flux and ATP production during liver cell glycolysis and is considered a potential drug target for the treatment of non-alcoholic fatty liver disease (NAFLD). In this study, we report the first ADP-competitive PKL inhibitors and identify several starting points for the further optimization of these inhibitors. Modeling and structural biology guided the optimization of a PKL-specific anthraquinone-based compound. A structure-activity relationship study of 47 novel synthetic derivatives revealed PKL inhibitors with half-maximal inhibitory concentration (IC 50 ) values in the 200 nM range. Despite the difficulty involved in studying a binding site as exposed as the ADP site, these derivatives feature expanded structural diversity and chemical spaces that may be used to improve their inhibitory activities against PKL. The obtained results expand the knowledge of the structural requirements for interactions with the ADP-binding site of PKL., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)
Published: 2022
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250. Development of small cyclic peptides targeting the CK2α/β interface.

Author: Atkinson EL, Iegre J, D'Amore C, Brear P, Salvi M, Hyvönen M, and Spring DR
Subjects: Crystallography, X-Ray, Models, Molecular, Peptides, Casein Kinase II chemistry, Casein Kinase II metabolism, Peptides, Cyclic pharmacology
Abstract: In this work, an iterative cycle of enzymatic assays, X-ray crystallography, molecular modelling and cellular assays were used to develop a functionalisable chemical probe for the CK2α/β PPI. The lead peptide, P8C9, successfully binds to CK2α at the PPI site, is easily synthesisable and functionalisable, highly stable in serum and small enough to accommodate further optimisation.
Published: 2022
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