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770 results on '"Breadmore, Michael C."'

234. Identification of Inorganic Improvised Explosive Devices by Analysis of Postblast Residues Using Portable Capillary Electrophoresis Instrumentation and Indirect Photometric Detection with a Light-Emitting Diode

Author

Hutchinson, Joseph P., primary, Evenhuis, Christopher J., additional, Johns, Cameron, additional, Kazarian, Artaches A., additional, Breadmore, Michael C., additional, Macka, Miroslav, additional, Hilder, Emily F., additional, Guijt, Rosanne M., additional, Dicinoski, Greg W., additional, and Haddad, Paul R., additional

Published
2007
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238. Electrokinetic Size and Mobility Traps for On-site Therapeutic Drug Monitoring.

Author

Guijt, Rosanne M., Shallan, Aliaa I., and Breadmore, Michael C.

Subjects
ELECTROKINETICS, DRUG monitoring, ANTIBIOTICS, DIELECTRIC breakdown, ELECTROPHORESIS
Abstract

The extraction of target analytes from biological samples is a bottleneck in analysis. A microfluidic device featuring an electrokinetic size and mobility trap was formed by two nanojunctions of different pore size to extract and concentrate analytical targets from complex samples. The trap was seamlessly coupled with electrophoretic separation for quantitative analysis. The device was applied to the analysis of ampicillin levels in blood within 5 min and a linear response over the range of 2.5-20 μg mL−1. This covers the recommended levels for treating sepsis, a critical condition with 30 to 50 % mortality and unpredicted drug levels. The device provides a new opportunity for on-site therapeutic drug monitoring, which should enable quick and accurate dosing and may save lives in such critical conditions. [ABSTRACT FROM AUTHOR]

Published
2015
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248. Microchip-Based Purification of DNA from Biological Samples

Author

Breadmore, Michael C., primary, Wolfe, Kelley A., additional, Arcibal, Imee G., additional, Leung, Wayne K., additional, Dickson, Dana, additional, Giordano, Braden C., additional, Power, Mary E., additional, Ferrance, Jerome P., additional, Feldman, Sanford H., additional, Norris, Pamela M., additional, and Landers, James P., additional

Published
2003
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250. Electrokinetic Extraction of Doxorubicin from Biological Fluids by Polymer Inclusion Membrane Sampling Probe

Author

Tey, Hui Yin, Breadmore, Michael C., and See, Hong Heng

Abstract

A polymer inclusion membrane (PIM) based sampling probe was developed for electrokinetic extraction of drugs from biological fluids. The probe was fabricated by dip-coating a nonconductive glass capillary tube in a homogeneous PIM solution for three cycles. The PIM solution comprised cellulose triacetate (CTA), 2-nitrophenyl octyl ether (NPOE), and 1-ethyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide [EMIM][NTf2] in a ratio of 5:4:2. The developed probe electrokinetically extracted doxorubicin from human plasma, human serum, and dried blood spot (DBS). The practicability and reliability of the electrokinetic extraction were evaluated by LC-MS/MS to quantify the desorption of extracted doxorubicin. Under the optimized conditions, a quantification limit of 0.2–2 ng/mL was achieved for the three biological samples. The probe was further integrated into a portable battery-powered device for safe low-voltage (36 V) electrokinetic extraction. The developed technique is envisioned to provide a more efficient analytical workflow in the laboratory.

Published
2023
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