Search

The growing need for interoperability among the different oceanic monitoring systems to deliver services able to answer the requirements of stakeholders and end-users led to the development of a low-cost machine-to-machine communication system able to guarantee data reliability over marine paths. In this framework, an experimental evaluation of the performance of long-range (LoRa) technology in a fully operational marine scenario has been proposed. In-situ tests were carried out exploiting the availability of (i) a passenger vessel and (ii) a research vessel operating in the Ligurian basin (North-Western Mediterranean Sea) both hosting end-nodes, and (iii) gateways positioned on mountains and hills in the inland areas. Packet loss ratio, packet reception rate, received signal strength indicator, signal to noise, and expected signal power ratio were chosen as metrics in line of sight and not the line of sight conditions. The reliability of Long Range Wide Area Network (LoRaWAN) transmission over the sea has been demonstrated up to more than 110 km in a free space scenario and for more than 20 km in a coastal urban environment.

The paper explores the potential of the satellite advanced differential synthetic aperture radar interferometry (A-DInSAR) technique for the identification of impending slope failure. The advantages and limitations of satellite InSAR in monitoring pre-failure landslide behaviour are addressed in five different case histories back-analysed using data acquired by different satellite missions: Montescaglioso landslide (2013, Italy), Scillato landslide (2015, Italy), Bingham Canyon Mine landslide (2013, UT, USA), Big Sur landslide (2017, CA, USA) and Xinmo landslide (2017, China). This paper aimed at providing a contribution to improve the knowledge within the subject area of landslide forecasting using monitoring data, in particular exploring the suitability of satellite InSAR for spatial and temporal prediction of large landslides. The study confirmed that satellite InSAR can be successful in the early detection of slopes prone to collapse; its limitations due to phase aliasing and low sampling frequency are also underlined. According to the results, we propose a novel landslide predictability classification discerning five different levels of predictability by satellite InSAR. Finally, the big step forward made for landslide forecasting applications since the beginning of the first SAR systems (ERS and Envisat) is shown, highlighting that future perspectives are encouraging thanks to the expected improvement of upcoming satellite missions that could highly increase the capability to monitor landslides’ pre-failure behaviour.

Edema is defined as a palpable swelling caused by an increase in interstitial fluid volume. Leg edema is a common problem with a wide range of possible causes and is the result of an imbalance in the filtration system between the capillary and interstitial spaces. Major causes of edema include venous obstruction, increased capillary permeability and increased plasma volume secondary to sodium and water retention. In both hospital and general practice, the patient with a swollen leg presents a common dilemma in diagnosis and treatment. The cause may be trivial or life-threatening and it is often difficult to determine the clinical pathway. The diagnosis can be narrowed by categorizing the edema according to its duration, distribution (unilateral or bilateral) and accompanying symptoms. This work provides clinically oriented recommendations for the management of leg edema in adults.

Se realizaron estudios arqueométricos que involucraron la aplicación de microscopía electrónica de barrido y técnicas termoanalíticas sobre distintas piezas óseas recuperadas del sitio de Boca de Lega (BL), Provincia de Santa Fe, Argentina. El material ósteoarqueológico recuperado de BL, exhibe una baja integridad mecánica y una distribución a nivel superficial, debido a procesos de acumulación de depósitos sedimentarios, re-depósitos y erosión del ambiente fluvial. También se observó signos de posible termoalteración. Los primeros estudios arqueométricos sobre un elemento denominado como BL21, lograron determinar la existencia de accionar antrópico de sociedades pretéritas. A partir de estos resultados, se avanzó en el análisis de otros elementos óseos de BL, denominados BL07, BL26 y BL49, mediante nuevos estudios arqueométricos en donde se aplicaron técnicas analíticas como ser: análisis térmico diferencial, termogramimetría y microscopía electrónica de barrido con microanálisis dispersivo de energías. El uso conjunto de estas técnicas permitió identificar la alta incidencia de componentes edáficos en las muestras como también el registro de un calentamiento que fue superior a 673K/400°C. En virtud de los resultados obtenidos fue posible reconfirmar el muy posible accionar humano como factor originario de la termoalteración previamente observada.

NK cells contribute to early defenses against viruses through their inborn abilities that include sensing of PAMPs and inflammatory signals such as cytokines or chemokines, recognition, and killing of infected cells through activating surface receptors engagement. Moreover, they support adaptive responses via Ab-dependent mechanisms, triggered by CD16, and DC editing. Their fundamental role in anti-viral responses has been unveiled in patients with NK cell deficiencies suffering from severe Herpesvirus infections. Notably, these infections, often occurring as primary infections early in life, can be efficiently cleared by NK, T, and B cells in healthy hosts. Herpesviruses however, generate a complicated balance with the host immune system through their latency cycle moving between immune control and viral reactivation. This lifelong challenge has contributed to the development of numerous evasion mechanisms by Herpesviruses, many of which devoted to elude NK cell surveillance from viral reactivations rather than primary infections. This delicate equilibrium can be altered in proportions of healthy individuals promoting virus reactivation and, more often, in immunocompromised subjects. However, the constant stimulus provided by virus-host interplay has also favored NK-cell adaptation to Herpesviruses. During anti-HCMV responses, NK cells can reshape their receptor repertoire and function, through epigenetic remodeling, and acquire adaptive traits such as longevity and clonal expansion abilities. The major mechanisms of recognition and effector responses employed by NK cells against Herpesviruses, related to their genomic organization will be addressed, including those allowing NK cells to generate memory-like responses. In addition, the mechanisms underlying virus reactivation or control will be discussed.

The Mediterranean community represented in this paper is the result of more than 30 years of EU and nationally funded coordination, which has led to key contributions in science concepts and operational initiatives. Together with the establishment of operational services, the community has coordinated with universities, research centers, research infrastructures and private companies to implement advanced multi-platform and integrated observing and forecasting systems that facilitate the advancement of operational services, scientific achievements and mission-oriented innovation. Thus, the community can respond to societal challenges and stakeholders needs, developing a variety of fit-for-purpose services such as the Copernicus Marine Service. The combination of state-of-the-art observations and forecasting provides new opportunities for downstream services in response to the needs of the heavily populated Mediterranean coastal areas and to climate change. The challenge over the next decade is to sustain ocean observations within the research community, to monitor the variability at small scales, e.g., the mesoscale/submesoscale, to resolve the sub-basin/seasonal and inter-annual variability in the circulation, and thus establish the decadal variability, understand and correct the model-associated biases and to enhance model-data integration and ensemble forecasting for uncertainty estimation. Better knowledge and understanding of the level of Mediterranean variability will enable a subsequent evaluation of the impacts and mitigation of the effect of human activities and climate change on the biodiversity and the ecosystem, which will support environmental assessments and decisions. Further challenges include extending the science-based added-value products into societal relevant downstream services and engaging with communities to build initiatives that will contribute to the 2030 Agenda and more specifically to SDG14 and the UN's Decade of Ocean Science for sustainable development, by this contributing to bridge the science-policy gap. The Mediterranean observing and forecasting capacity was built on the basis of community best practices in monitoring and modeling, and can serve as a basis for the development of an integrated global ocean observing system.

The European Research Infrastructure Consortium “Integrated Carbon Observation System” (ICOS) aims at delivering high quality greenhouse gas (GHG) observations and derived data products (e.g., regional GHG-flux maps) for constraining the GHG balance on a European level, on a sustained long-term basis. The marine domain (ICOS-Oceans) currently consists of 11 Ship of Opportunity lines (SOOP – Ship of Opportunity Program) and 10 Fixed Ocean Stations (FOSs) spread across European waters, including the North Atlantic and Arctic Oceans and the Barents, North, Baltic, and Mediterranean Seas. The stations operate in a harmonized and standardized way based on community-proven protocols and methods for ocean GHG observations, improving operational conformity as well as quality control and assurance of the data. This enables the network to focus on long term research into the marine carbon cycle and the anthropogenic carbon sink, while preparing the network to include other GHG fluxes. ICOS data are processed on a near real-time basis and will be published on the ICOS Carbon Portal (CP), allowing monthly estimates of CO2 air-sea exchange to be quantified for European waters. ICOS establishes transparent operational data management routines following the FAIR (Findable, Accessible, Interoperable, and Reusable) guiding principles allowing amongst others reproducibility, interoperability, and traceability. The ICOS-Oceans network is actively integrating with the atmospheric (e.g., improved atmospheric measurements onboard SOOP lines) and ecosystem (e.g., oceanic direct gas flux measurements) domains of ICOS, and utilizes techniques developed by the ICOS Central Facilities and the CP. There is a strong interaction with the international ocean carbon cycle community to enhance interoperability and harmonize data flow. The future vision of ICOS-Oceans includes ship-based ocean survey sections to obtain a three-dimensional understanding of marine carbon cycle processes and optimize the existing network design.

NK cells are generated from hematopoietic stem cells (HSC) residing in the bone marrow (BM), similar to other blood cells. Development toward mature NK cells occurs largely outside the BM through travel of CD34+ and other progenitor intermediates toward secondary lymphoid organs. The BM harbors multipotent CD34+ common lymphoid progenitors (CLPs) that generate T, B, NK, and Dendritic Cells and are devoid of erythroid, myeloid, and megakaryocytic potential. Over recent years, there has been a quest for single-lineage progenitors predominantly with the objective of manipulation and intervention in mind, which has led to the identification of unipotent NK cell progenitors devoid of other lymphoid lineage potential. Research efforts for the study of lymphopoiesis have almost exclusively concentrated on healthy donor tissues and on repopulation/transplant models. This has led to the widely accepted assumption that lymphopoiesis during disease states reflects the findings of these models. However, compelling evidences in animal models show that inflammation plays a fundamental role in the regulation of HSC maturation and release in the BM niches through several mechanisms including modulation of the CXCL12-CXCR4 expression. Indeed, recent findings during systemic inflammation in patients provide evidence that a so-far overlooked CLP exists in the BM (Lin−CD34+DNAM-1brightCXCR4+) and that it overwhelmingly exits the BM during systemic inflammation. These “inflammatory” precursors have a developmental trajectory toward surprisingly functional NK and T cells as reviewed here and mirror the steady state maintenance of the NK cell pool by CD34+DNAM-1−CXCR4− precursors. Our understanding of NK cell precursor development may benefit from including a distinct “inflammatory” progenitor modeling of lymphoid precursors, allowing rapid deployment of specialized Lin−CD34+DNAM-1brightCXCR4+ -derived resources from the BM.

The oceans play a key role in global issues such as climate change, food security, and human health. Given their vast dimensions and internal complexity, efficient monitoring and predicting of the planet’s ocean must be a collaborative effort of both regional and global scale. A first and foremost requirement for such collaborative ocean observing is the need to follow well-defined and reproducible methods across activities: from strategies for structuring observing systems, sensor deployment and usage, and the generation of data and information products, to ethical and governance aspects when executing ocean observing. To meet the urgent, planet-wide challenges we face, methods across all aspects of ocean observing should be broadly adopted by the ocean community and, where appropriate, should evolve into “Ocean Best Practices.” While many groups have created best practices, they are scattered across the Web or buried in local repositories and many have yet to be digitized. To reduce this fragmentation, we introduce a new open access, permanent, digital repository of best practices documentation (oceanbestpractices.org) that is part of the Ocean Best Practices System (OBPS). The new OBPS provides an opportunity space for the centralized and coordinated improvement of ocean observing methods. The OBPS repository employs user-friendly software to significantly improve discovery and access to methods. The software includes advanced semantic technologies for search capabilities to enhance repository operations. In addition to the repository, the OBPS also includes a peer reviewed journal research topic, a forum for community discussion and a training activity for use of best practices. Together, these components serve to realize a core objective of the OBPS, which is to enable the ocean community to create superior methods for every activity in ocean observing from research to operations to applications that are agreed upon and broadly adopted across communities. Using selected ocean observing examples, we show how the OBPS supports this objective. This paper lays out a future vision of ocean best practices and how OBPS will contribute to improving ocean observing in the decade to come.

A new process for oxygen enriched air (EA) production has been applied to Claus Process. This process is simple and requires few process units. Matlab and Aspen Hysys have been used for simulations and system sizing. The results demonstrate that it could be an alternative to traditional EA processes from an economical point of view.

Marine in situ gamma-ray spectrometry was utilized for a rainfall study at the W1M3A observing system in Ligurian Sea, Mediterranean Sea, Italy. From 7 June to 10 October 2016, underwater total gamma-ray counting rate (TCR) and the activity concentration of radon daughters 214Pb, 214Bi and potassium 40K were continuously monitored along with ambient noise and meteorological parameters. TCR was proven as a good rainfall indicator as radon daughters’ fallout resulted in increased levels of marine radioactivity during and 2–3 h after the rainfall events. Cloud origin significantly affects TCR and radon progenies variations, as aerial mass trajectories, which extend upon terrestrial areas, result in higher increments. TCR and radon progenies concentrations revealed an increasing non-linear trend with rainfall height and intensity. 40K was proven to be an additional radio-tracer as its dilution was associated with rainfall height. 40K variations combined with 214Bi measurements can be used to investigate the mixing of rain- and seawater. In comparison with measurements in the atmosphere, the application of marine in situ gamma-ray spectrometry for precipitation investigation provided important advantages: allows quantitative measurement of the radionuclides; 40K can be used, along with radon daughters, as a radio-tracer; the mixing of rain- and seawater can be associated with meteorological parameters.

This work presents the first results obtained by applying in situ and remote-sensing methodologies to monitor the Ponte della Musica-Armando Trovajoli located in Rome, within the activities of the WP6 “Structural Health Monitoring and Satellite Data” 2019-21 Reluis Project. In particular, the use of remote-sensing Differential Synthetic Aperture Radar (SAR) Interferometry (DInSAR) measurements provided a spatial map of the displacement of the investigated infrastructure and the corresponding time-series, with the aim of monitoring deformation phenomena, focusing on the local scale analysis, which produces suitable results for urban monitoring and damage assessment. The DInSAR results have been integrated with the identification of the dynamic characteristics of the bridge, performed through an experimental campaign of ambient vibration measurements carried out in October 2020 and with the local-scale definition of the engineering geological setting of the foundation soil. The subsoil of the bridge is constituted by more than 50 m of recent alluvial deposits resting on Pliocene stiff clay acting as a geological bedrock. A substantially stable behavior of the bridge structural elements has been observed based on the analysis of both satellite and velocimetric data. This case represents a good example about how the integration of in situ sensors with remotely sensed data and the exploitation of a detailed knowledge regarding the on-site conditions represent a key factor for a sustainable structural and infrastructural monitoring and can support the planning both of maintenance and safety management.

Mining exploitation leads to slow or rapid ground subsidence resulting from deformation until the collapse of underground post-mining voids following excavation activities. Satellite SAR interferometry capabilities for the evaluation of ground movements allows the monitoring of intensive surface mine subsidence and can provide new knowledge about the risks in the mining industry. This work integrates both conventional and advanced Differential SAR Interferometry (DInSAR) to study the ground subsidence in the Legnica Glogow Copper District (LGCD, Poland) by processing about 400 Sentinel-1 images from October 2014 to April 2019. Even without field data and information on past and ongoing excavation activities, the DInSAR approach allowed us to identify 30 troughs of subsidence, ranging from 500 m to 2.5 km in diameter, which in some cases, took place several times during the analyzed time span. The cumulative subsidence in 4 years and 7 months exceeds 70 cm in several zones of the LGCD. The sub-centimetric precision achieved by advanced analysis (A-DInSAR), allowed us to monitor the real extent of the mining influence area on the surface, with deformation velocities of up to 50 mm/year. The ground deformation detected at LGCD can be due to both mining-induced tremors and roof subsidence above the underground excavation rooms. As deformations do not occur concurrently with tremors, this can be related to excavation activities or to degradation of abandoned mines.

The failures of tailings dams have a major negative impact on the economy, surrounding properties, and people’s lives, and therefore the monitoring of these facilities is crucial to mitigate the risk of failure, but this can be challenging due to their size and inaccessibility. In this work, the deformation processes at Żelazny Most tailings dam (Poland) were analyzed using satellite Ad-vanced Differential SAR Interferometry (A-DInSAR) from October 2014 to April 2019, showing that the dam is affected by both settlements (with a maximum rate of 30 mm/yr), and horizontal sliding in radial direction with respect to the ponds. The load of the tailings is pushing the dam forward along the glacio-tectonic shear planes located at depth, in the Pliocene clays, causing horizontal displacements at a rate up to 30 mm/yr, which could lead to a passive failure of the dam. The measured displacements have been compared with the ones observed by in situ data from the 90s to 2013, available in the literature. The outcomes indicate that intense localized deformations occur in the eastern and northern sectors of the dam, while the western sector is deforming evenly. Moreover, although the horizontal deformation had a slowdown from 2010 until 2013, it continued in 2014 to 2019 with recovered intensity. The upper and the recent embankments are affected by major settlements, possibly due to a lower consolidation degree of the most recent tailings and a larger thickness of compressible materials.

Current measurements in the open sea are generally acquired by Acoustic Doppler Current Profilers (ADCPs). In the case of ADCPs mounted on spar buoy, current profiles require to be post-processed, to properly take into account the buoy influence: in fact, ADCP compass may reflect alterations induced by the metal structure of the buoy and apparent currents can occur due to the large displacement of the platform. Uncertainty analysis is finally required to properly consider both these effects and to compute robust velocity estimates. A new methodology is tested for a measurement station in the Ligurian Sea, where an ADCP was mounted on the surface buoy of the W1-M3A (Western 1 Mediterranean Moored Multisensor Array) oceanographic observatory, facing upwards at the depth of about 40 m. Marine current numerical models and historical data in the area have been used as a basis for comparison to test the consistency of the proposed method. A very good agreement is obtained. Only minor discrepancies are reported (e.g., monthly averages from the reference model slightly underestimate the west-east current component along the entire profile), but, in general, the application of the proposed methodology ensures that the spar buoy-mounted ADCP system is able to provide reliable measurements for oceanographic studies and validation of 3D hydrodynamic models.