4,139 results on '"Boutron-Ruault, Marie-Christine"'
Search Results
202. Breast Cancer Incidence in Relation to Long-Term Low-Level Exposure to Air Pollution in the ELAPSE Pooled Cohort
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Hvidtfeldt, Ulla Arthur, primary, Chen, Jie, additional, Rodopoulou, Sophia, additional, Strak, Maciej, additional, de Hoogh, Kees, additional, Andersen, Zorana J., additional, Bellander, Tom, additional, Brandt, Jørgen, additional, Fecht, Daniela, additional, Forastiere, Francesco, additional, Gulliver, John, additional, Hertel, Ole, additional, Hoffmann, Barbara H., additional, Katsouyanni, Klea, additional, Ketzel, Matthias, additional, Brynedal, Boel, additional, Leander, Karin, additional, Ljungman, Petter L.S., additional, Magnusson, Patrik K.E., additional, Nagel, Gabriele, additional, Pershagen, Göran, additional, Rizzuto, Debora, additional, Boutron-Ruault, Marie-Christine, additional, Samoli, Evangelia, additional, So, Rina, additional, Stafoggia, Massimo, additional, Tjønneland, Anne, additional, Vermeulen, Roel, additional, Verschuren, W.M. Monique, additional, Weinmayr, Gudrun, additional, Wolf, Kathrin, additional, Zhang, Jiawei, additional, Zitt, Emanuel, additional, Brunekreef, Bert, additional, Hoek, Gerard, additional, and Raaschou-Nielsen, Ole, additional
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- 2022
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203. Food Processing and Risk of Crohn’s Disease and Ulcerative Colitis: A European Prospective Cohort Study
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Meyer, Antoine, primary, Dong, Catherine, additional, Casagrande, Corinne, additional, Chan, Simon S.M., additional, Huybrechts, Inge, additional, Nicolas, Geneviève, additional, Rauber, Fernanda, additional, Levy, Renata Bertazzi, additional, Millett, Christopher, additional, Oldenburg, Bas, additional, Weiderpass, Elisabete, additional, Heath, Alicia K., additional, Tong, Tammy Y.N., additional, Tjønneland, Anne, additional, Kyrø, Cecilie, additional, Kaaks, Rudolf, additional, Katzke, Verena A., additional, Bergman, Manuela M., additional, Palli, Domenico, additional, Masala, Giovanna, additional, Tumino, Rosario, additional, Sacerdote, Carlotta, additional, Colorado-Yohar, Sandra M., additional, Sánchez, Maria-Jose, additional, Grip, Olof, additional, Lindgren, Stefan, additional, Luben, Robert, additional, Gunter, Marc J., additional, Mahamat-Saleh, Yahya, additional, Boutron-Ruault, Marie-Christine, additional, and Carbonnel, Franck, additional
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- 2022
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204. Association between beverage consumption and risk of rheumatoid arthritis: a prospective study from the French E3N Cohort
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Ascione, Sophia, primary, Barde, François, additional, Artaud, Fanny, additional, Nguyen, Yann, additional, Macdonald, Conor, additional, Mariette, Xavier, additional, Boutron-Ruault, Marie-Christine, additional, Salliot, Carine, additional, and Seror, Raphaèle, additional
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- 2022
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205. Adherence to mediterranean diet and the risk of differentiated thyroid cancer in a European cohort: The EPIC study
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Llaha, Fjorida, primary, Cayssials, Valerie, additional, Farràs, Marta, additional, Agudo, Antonio, additional, Sandström, Maria, additional, Eriksen, Anne Kirstine, additional, Tjønneland, Anne, additional, Boutron-Ruault, Marie-Christine, additional, Laouali, Nasser, additional, Truong, Thérèse, additional, Le Cornet, Charlotte, additional, Katzke, Verena, additional, Schulze, Matthias, additional, Palli, Domenico, additional, Krogh, Vittorio, additional, Signoriello, Simona, additional, Tumino, Rosario, additional, Ricceri, Fulvio, additional, Skeie, Guri, additional, Jensen, Torill Miriam Enget, additional, Chen, Sairah Lai Fa, additional, Lasheras, Cristina, additional, Rodriguez-Barranco, Miguel, additional, Amiano, Pilar, additional, Huerta, José María, additional, Guevara, Marcela, additional, Almquist, Martin, additional, Nilson, Lena Maria, additional, Hennings, Joakim, additional, Papier, Keren, additional, Heath, Alicia, additional, Weiderpass, Elisabete, additional, Rinaldi, Sabina, additional, and Zamora-Ros, Raul, additional
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- 2022
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206. Relative to processed red meat, alternative protein sources are associated with a lower risk of hypertension and diabetes in a prospective cohort of French women
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Thao, Uyen, primary, Lajous, Martin, additional, Laouali, Nasser, additional, Severi, Gianluca, additional, Boutron-Ruault, Marie-Christine, additional, and MacDonald, Conor James, additional
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- 2022
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207. Processed and unprocessed red meat consumption and hypertension in women , ,
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Lajous, Martin, Bijon, Anne, Fagherazzi, Guy, Rossignol, Emilie, Boutron-Ruault, Marie-Christine, and Clavel-Chapelon, Françoise
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- 2014
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208. Anthropometric features and cutaneous melanoma risk: A prospective cohort study in French women
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Kvaskoff, Marina, Bijon, Anne, Mesrine, Sylvie, Vilier, Alice, Clavel-Chapelon, Françoise, and Boutron-Ruault, Marie-Christine
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- 2014
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209. Circulating concentrations of vitamin D in relation to pancreatic cancer risk in European populations
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van Duijnhoven, Fränzel J.B., Jenab, Mazda, Hveem, Kristian, Siersema, Peter D., Fedirko, Veronika, Duell, Eric J., Kampman, Ellen, Halfweeg, Anouk, van Kranen, Henk J., van den Ouweland, Jody M.W., Weiderpass, Elisabete, Murphy, Neil, Langhammer, Arnulf, Ness‐Jensen, Eivind, Olsen, Anja, Tjønneland, Anne, Overvad, Kim, Cadeau, Claire, Kvaskoff, Marina, Boutron‐Ruault, Marie‐Christine, Katzke, Verena A., Kühn, Tilman, Boeing, Heiner, Trichopoulou, Antonia, Kotanidou, Anastasia, Kritikou, Maria, Palli, Domenico, Agnoli, Claudia, Tumino, Rosario, Panico, Salvatore, Matullo, Giuseppe, Peeters, Petra, Brustad, Magritt, Olsen, Karina Standahl, Lasheras, Cristina, Obón‐Santacana, Mireia, Sánchez, María‐José, Dorronsoro, Miren, Chirlaque, Maria‐Dolores, Barricarte, Aurelio, Manjer, Jonas, Almquist, Martin, Renström, Frida, Ye, Weimin, Wareham, Nick, Khaw, Kay‐Tee, Bradbury, Kathryn E., Freisling, Heinz, Aune, Dagfinn, Norat, Teresa, Riboli, Elio, and Bueno‐de‐Mesquita, H. B(as)
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- 2018
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210. Colonoscopy reduced distal colorectal cancer risk and excess cancer risk associated with family history
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Morois, Sophie, Cottet, Vanessa, Racine, Antoine, Clavel-Chapelon, Françoise, Carbonnel, Franck, Bastide, Nadia, and Boutron-Ruault, Marie-Christine
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- 2014
211. Prediagnostic Serum Vitamin D Levels and the Risk of Crohn’s Disease and Ulcerative Colitis in European Populations: A Nested Case-Control Study
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Opstelten, Jorrit L, Chan, Simon S M, Hart, Andrew R, van Schaik, Fiona D M, Siersema, Peter D, Lentjes, Eef G W M, Khaw, Kay-Tee, Luben, Robert, Key, Timothy J, Boeing, Heiner, Bergmann, Manuela M, Overvad, Kim, Palli, Domenico, Masala, Giovanna, Racine, Antoine, Carbonnel, Franck, Boutron-Ruault, Marie-Christine, Tjønneland, Anne, Olsen, Anja, Andersen, Vibeke, Kaaks, Rudolf, Kühn, Tilman, Tumino, Rosario, Trichopoulou, Antonia, Peeters, Petra H M, Verschuren, W M Monique, Witteman, Ben J M, and Oldenburg, Bas
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- 2018
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212. Consumption of fruits, vegetables and fruit juices and differentiated thyroid carcinoma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study
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Zamora‐Ros, Raul, Béraud, Virginie, Franceschi, Silvia, Cayssials, Valerie, Tsilidis, Konstantinos K., Boutron‐Ruault, Marie‐Christine, Weiderpass, Elisabete, Overvad, Kim, Tjønneland, Anne, Eriksen, Anne K., Bonnet, Fabrice, Affret, Aurélie, Katzke, Verena, Kühn, Tilman, Boeing, Heiner, Trichopoulou, Antonia, Valanou, Elisavet, Karakatsani, Anna, Masala, Giovanna, Grioni, Sara, Santucci de Magistris, Maria, Tumino, Rosario, Ricceri, Fulvio, Skeie, Guri, Parr, Christine L, Merino, Susana, Salamanca‐Fernández, Elena, Chirlaque, Maria‐Dolores, Ardanaz, Eva, Amiano, Pilar, Almquist, Martin, Drake, Isabel, Hennings, Joakim, Sandström, Maria, Bueno‐de‐Mesquita, H. B(as), Peeters, Petra H., Khaw, Kay‐Thee, Wareham, Nicholas J., Schmidt, Julie A., Perez‐Cornago, Aurora, Aune, Dagfinn, Riboli, Elio, Slimani, Nadia, Scalbert, Augustin, Romieu, Isabelle, Agudo, Antonio, and Rinaldi, Sabina
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- 2018
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213. Fibre intake and the development of inflammatory bowel disease: A European prospective multi-centre cohort study (EPIC-IBD)
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Andersen, Vibeke, Chan, Simon, Luben, Robert, Khaw, Kay-Tee, Olsen, Anja, Tjonneland, Anne, Kaaks, R, Grip, Olof, Bergmann, M M, Boeing, H, Hultdin, Johan, Karling, Pontus, Overvad, Kim, Oldenburg, Bas, Opstelten, Jorrit, Boutron-Ruault, Marie-Christine, Carbonnel, Franck, Racine, Antoine, Key, Timothy, Masala, Giovanna, Palli, Domenico, Tumino, R, Trichopoulou, A, Riboli, Elio, and Hart, Andrew
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- 2018
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214. Dietary intake of acrylamide and esophageal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort
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Lujan-Barroso, Leila, González, Carlos Alberto, Slimani, Nadia, Obón-Santacana, Mireia, Ferrari, Pietro, Freisling, Heinz, Overvad, Kim, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Racine, Antoine, Katzke, Verena, Kühn, Tilman, Tjønneland, Anne, Olsen, Anja, Quirós, J. Ramón, Sánchez-Cantalejo, Emilio, Amiano, Pilar, Navarro, Carmen, Barricarte, Aurelio, Khaw, Kay-Tee, Wareham, Nick, Travis, Ruth C., Trichopoulou, Antonia, Bamia, Christina, Benetou, Vassiliki, Saieva, Calogero, Grioni, Sara, Tumino, Rosario, Vineis, Paolo, Mattiello, Amalia, Bueno-de-Mesquita, H. Bas, Siersema, Peter D., Numans, Mattijs E., Peeters, Petra H., Ericson, Ulrika, Wirfält, Elisabet, Sund, Malin, Johansson, Mattias, Weiderpass, Elisabete, Skeie, Guri, Riboli, Elio, Boeing, Heiner, and Duell, Eric J.
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- 2014
215. C-reactive protein and postmenopausal breast cancer risk: results from the E3N cohort study
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Dossus, Laure, Jimenez-Corona, Aida, Romieu, Isabelle, Boutron-Ruault, Marie-Christine, Boutten, Anne, Dupré, Thierry, Fagherazzi, Guy, Clavel-Chapelon, Francoise, and Mesrine, Sylvie
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- 2014
216. Brief Report: Body Mass Index, Diabetes, and Mortality in French Women: Explaining Away a "Paradox"
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Lajous, Martin, Bijon, Anne, Fagherazzi, Guy, Boutron-Ruault, Marie-Christine, Balkau, Beverley, Clavel-Chapelon, Françoise, and Hernán, Miguel A.
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- 2014
217. Fruit and vegetable intake and cause-specific mortality in the EPIC study
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Leenders, Max, Boshuizen, Hendriek C., Ferrari, Pietro, Siersema, Peter D., Overvad, Kim, Tjønneland, Anne, Olsen, Anja, Boutron-Ruault, Marie-Christine, Dossus, Laure, Dartois, Laureen, Kaaks, Rudolf, Li, Kuanrong, Boeing, Heiner, Bergmann, Manuela M., Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Palli, Domenico, Krogh, Vittorio, Panico, Salvatore, Tumino, Rosario, Vineis, Paolo, Peeters, Petra H. M., Weiderpass, Elisabete, Engeset, Dagrun, Braaten, Tonje, Redondo, Maria Luisa, Agudo, Antonio, Sánchez, María-José, Amiano, Pilar, Huerta, José-María, Ardanaz, Eva, Drake, Isabel, Sonestedt, Emily, Johansson, Ingegerd, Winkvist, Anna, Khaw, Kay-Tee, Wareham, Nick J., Key, Timothy J., Bradbury, Kathryn E., Johansson, Mattias, Licaj, Idlir, Gunter, Marc J., Murphy, Neil, Riboli, Elio, and Bueno-de-Mesquita, H. Bas
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- 2014
218. Wine consumption throughout life is inversely associated with type 2 diabetes risk, but only in overweight individuals: results from a large female French cohort study
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Fagherazzi, Guy, Vilier, Alice, Lajous, Martin, Boutron-Ruault, Marie-Christine, Balkau, Beverley, Clavel-Chapelon, Françoise, and Bonnet, Fabrice
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- 2014
219. Biomarker patterns of inflammatory and metabolic pathways are associated with risk of colorectal cancer: results from the European Prospective Investigation into Cancer and Nutrition (EPIC)
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Aleksandrova, Krasimira, Jenab, Mazda, Bueno-de-Mesquita, H. Bas, Fedirko, Veronika, Kaaks, Rudolf, Lukanova, Annekatrin, van Duijnhoven, Fränzel J. B., Jansen, Eugene, Rinaldi, Sabina, Romieu, Isabelle, Ferrari, Pietro, Murphy, Neil, Gunter, Marc J., Riboli, Elio, Westhpal, Sabine, Overvad, Kim, Tjønneland, Anne, Halkjær, Jytte, Boutron-Ruault, Marie-Christine, Dossus, Laure, Racine, Antoine, Trichopoulou, Antonia, Bamia, Christina, Orfanos, Philippos, Agnoli, Claudia, Palli, Domenico, Panico, Salvatore, Tumino, Rosario, Vineis, Paolo, Peeters, Petra H., Duell, Eric J., Molina-Montes, Esther, Quirós, J. Ramón, Dorronsoro, Miren, Chirlaque, Maria-Dolores, Barricarte, Aurelio, Ljuslinder, Ingrid, Palmqvist, Richard, Travis, Ruth C., Khaw, Kay-Tee, Wareham, Nicholas, Pischon, Tobias, and Boeing, Heiner
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- 2014
220. Thyroid dysfunction and breast cancer risk among women in the UK Biobank cohort
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Tran, Thi-Van-Trinh, Maringe, Camille, Benitez Majano, Sara, Rachet, Bernard, Boutron-Ruault, Marie-Christine, and Journy, Neige
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Adult ,endocrine system ,endocrine system diseases ,Age Factors ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Breast Neoplasms ,Middle Aged ,United Kingdom ,Cohort Studies ,breast cancer ,Risk Factors ,Confidence Intervals ,Prevalence ,cohort study ,incidence ,Humans ,hyperthyroidism ,Female ,hypothyroidism ,Cancer Prevention ,RC254-282 ,Original Research ,Aged ,Proportional Hazards Models - Abstract
This study aimed to evaluate the association between thyroid dysfunction and breast cancer risk. We included 239,436 females of the UK Biobank cohort. Information on thyroid dysfunction, personal and family medical history, medications, reproductive factors, lifestyle, and socioeconomic characteristics was retrieved from baseline self‐reported data and hospital inpatient databases. Breast cancer diagnoses were identified through population‐based registries. We computed Cox models to estimate hazard ratios (HRs) of breast cancer incidence for thyroid dysfunction diagnosis and treatments, and examined potential confounding and effect modification by comorbidities and breast cancer risk factors. In our study, 3,227 (1.3%) and 20,762 (8.7%) women had hyper‐ and hypothyroidism prior to the baseline. During a median follow‐up of 7.1 years, 5,326 (2.2%) women developed breast cancer. Compared to no thyroid dysfunction, there was no association between hypothyroidism and breast cancer risk overall (HR = 0.93, 95% confidence interval (CI): 0.84–1.02, 442 cases), but we found a decreased risk more than 10 years after hypothyroidism diagnosis (HR=0.85, 95%CI 0.74–0.97, 226 cases). There was no association with hyperthyroidism overall (HR=1.08, 95%CI 0.86–1.35, 79 cases) but breast cancer risk was elevated among women with treated hyperthyroidism (HR=1.38, 95%CI: 1.03–1.86, 44 cases) or aged 60 years or more at hyperthyroidism diagnosis (HR=1.74, 95%CI: 1.01–3.00, 113 cases), and 5–10 years after hyperthyroidism diagnosis (HR=1.58, 95%CI: 1.06–2.33, 25 cases). In conclusion, breast cancer risk was reduced long after hypothyroidism diagnosis, but increased among women with treated hyperthyroidism. Future studies are needed to determine whether the higher breast cancer risk observed among treated hyperthyroidism could be explained by hyperthyroidism severity, type of treatment or aetiology., In this study, we included 239,436 women in the general population‐based UK Biobank cohort to investigate the association between thyroid dysfunction and breast cancer risk. Our study suggested there was no association between hyper‐ and hypothyroidism in overall and breast cancer risk. However, among treated hyperthyroidism, we found a higher breast cancer risk, which could be explained by hyperthyroidism severity or aetiology.
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- 2021
221. List of Contributors
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Agostoni, Carlo, primary, Agrawal, Sutapa, additional, Alexy, Ute, additional, Alix Timko, C., additional, Alles, Benjamin, additional, Attini, Rossella, additional, Bae, Yun-Jung, additional, Barnard, Neal D., additional, Bemrah, Nawel, additional, Bettocchi, Silvia, additional, Boutron-Ruault, Marie-Christine, additional, Burns, Patricia, additional, Cabiddu, Gianfranca, additional, Capizzi, Irene, additional, Clarys, Peter, additional, Cleveland, David A., additional, Clifton, Peter, additional, Combet, Emilie, additional, Dagnelie, Pieter C., additional, Dauchet, Luc, additional, De Cosmi, Valentina, additional, Deriemaeker, Peter, additional, Fardet, Anthony, additional, Filippi, Massimo, additional, Fleury, Ségolène, additional, Foster, Meika, additional, Gee, Quentin, additional, Glick-Bauer, Marian, additional, Gorczyca, Daiva, additional, Hebbelinck, Marcel, additional, Heiss, Sydney, additional, Herrmann, Wolfgang, additional, Hoffman, Sarah R., additional, Hormes, Julia M., additional, Iikura, Motoyasu, additional, Jallinoja, Piia, additional, Janz, Nicole, additional, Johnston, Carol S., additional, Jung, Jae G., additional, Jung, Sarah, additional, Kahleova, Hana, additional, Kang, Hyoun W., additional, Katz, David L., additional, Kehoe, Sarah H., additional, Kersting, Mathilde, additional, Key, Timothy J., additional, Krishnaveni, Ghattu V., additional, Kumaran, Kalyanaraman, additional, Leone, Filomena, additional, Loi, Valentina, additional, Mangano, Kelsey M., additional, Mann, Jim, additional, Mariotti, François, additional, Maxia, Stefania, additional, Mazzocchi, Alessandra, additional, Mesrine, Sylvie, additional, Miyamoto, Yoshihiro, additional, Moretti, Diego, additional, Nath, Preetam, additional, Nishimura, Kunihiro, additional, Niva, Mari, additional, Nougadère, Alexandre, additional, Obersby, Derek, additional, Orlich, Michael J., additional, Pelikanova, Terezie, additional, Piccoli, Giorgina B., additional, Pierre, Fabrice, additional, Reinheimer, Jorge, additional, Riccitelli, Gianna C., additional, Rivière, Gilles, additional, Rocca, Maria A., additional, Rothgerber, Hank, additional, Samman, Samir, additional, Sanders, Thomas A.B., additional, Scaglioni, Silvia, additional, Schomburg, Lutz, additional, Siapco, Gina, additional, Singh, Shivaram Prasad, additional, Thies, Frank, additional, Todros, Tullia, additional, Tonstad, Serena, additional, Touvier, Mathilde, additional, Tsiami, Amalia, additional, Tucker, Katherine L., additional, Vacchi, Laura, additional, Vainio, Annukka, additional, van Berleere, Marine, additional, Vinderola, Gabriel, additional, Walsh, Stephen, additional, Wien, Michelle, additional, Winnie Gerbens-Leenes, P., additional, Yeh, Ming-Chin, additional, and Yokoyama, Yoko, additional
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- 2017
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222. Meat Consumption and Health Outcomes
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Boutron-Ruault, Marie-Christine, primary, Mesrine, Sylvie, additional, and Pierre, Fabrice, additional
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- 2017
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223. Dietary Polyphenols in the Aetiology of Crohnʼs Disease and Ulcerative Colitis—A Multicenter European Prospective Cohort Study (EPIC)
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Lu, Yunxia, Zamora-Ros, Raul, Chan, Simon, Cross, Amanda J., Ward, Heather, Jakszyn, Paula, Luben, Robert, Opstelten, Jorrit L., Oldenburg, Bas, Hallmans, Göran, Karling, Pontus, Grip, Olof, Key, Timothy, Bergmann, Manuela M., Boeing, Heiner, Overvad, Kim, Palli, Domenico, Masala, Giovanna, Khaw, Kay-Tee, Racine, Antoine, Carbonnel, Franck, Boutron-Ruault, Marie-Christine, Andersen, Vibeke, Olsen, Anja, Tjonneland, Anne, Kaaks, Rudolf, Tumino, Rosario, Trichopoulou, Antonia, Scalbert, Augustin, Riboli, Elio, and Hart, Andrew R.
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- 2017
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224. Relative to processed red meat, alternative protein sources are associated with a lower risk of hypertension and diabetes in a prospective cohort of French women.
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Thao, Uyen, Lajous, Martin, Laouali, Nasser, Severi, Gianluca, Boutron-Ruault, Marie-Christine, and MacDonald, Conor James
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HYPERTENSION risk factors ,DIABETES risk factors ,EGGS ,MEAT ,CONFIDENCE intervals ,FOOD security ,SELF-evaluation ,FOOD animals ,PACKAGED foods ,COMPARATIVE studies ,QUESTIONNAIRES ,DESCRIPTIVE statistics ,DIETARY proteins ,WOMEN'S health ,LONGITUDINAL method ,PROPORTIONAL hazards models - Abstract
Many dietary guidelines recommend restricting the consumption of processed red meat (PRM) in favour of healthier foods such as fish, to reduce the risk of chronic conditions such as hypertension and diabetes. The objective of this study was to estimate the potential effect of replacing PRM for fatty fish, lean fish, red meat, eggs, pulses, or vegetables, on the risk of incident hypertension and diabetes. This was a prospective study of women in the E3N cohort study. Cases of diabetes and hypertension were based on self-report, specific questionnaires, and drug reimbursements. In the main analysis, information on regular dietary intake was assessed with a single food history questionaire, and food substitutions were modelled using cox proportional hazard models. 95 % confidence intervals were generated via bootstrapping. 71 081 women free of diabetes and 45 771 women free of hypertension were followed for an average of 18·7 and 18·3 years, respectively. 2681 incident cases of diabetes and 12 327 incident cases of hypertension were identified. Relative to PRM, fatty fish was associated with a 15 % lower risk of diabetes (HR = 0·85, 95 CI (0·73, 0·97)) and hypertension (HR = 0 85 (0·79, 0·91)). Between 3 and 10 % lower risk of hypertension or diabetes was also observed when comparing PRM with vegetables, unprocessed red meat or pulses. Relative to PRM, alternative protein sources such as fatty fish, unprocessed red meat, vegetables or pulses was associated with a lower risk of hypertension and diabetes. [ABSTRACT FROM AUTHOR]
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- 2023
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225. Reproductive characteristics, use of exogenous hormones and Parkinson disease in women from the E3N study.
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Pesce, Giancarlo, Artaud, Fanny, Roze, Emmanuel, Degaey, Isabelle, Portugal, Berta, Nguyen, Thi Thu Ha, Fournier, Agnès, Boutron-Ruault, Marie-Christine, Severi, Gianluca, Elbaz, Alexis, and Canonico, Marianne
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PREMATURE menopause ,PARKINSON'S disease ,MEDICAL record databases ,DISEASE incidence ,ORAL contraceptives ,HORMONE therapy - Abstract
Despite experimental studies suggesting a disease-modifying role of oestrogens, results from epidemiological studies on the relation of reproductive characteristics and hormonal exposures with Parkinson disease in women are conflicting. We used the data from the E3N cohort study including 98,068 women aged 40-65y in 1990 followed until 2018. Parkinson disease was ascertained using a validation process based on drug claim databases and medical records. Reproductive characteristics and hormonal exposures were self-reported (11 questionnaires). Associations of exposures with Parkinson disease incidence were investigated using time-varying Cox proportional hazards regression with a 5-year exposure lag and age as the time scale adjusted for confounders. We identified 1165 incident Parkinson disease cases during a mean follow-up of 22.0 years (incidence rate = 54.7 per 100 000 person-years). Parkinson disease incidence was higher in women with early (<12y, hazard ratio [HR] = 1.21, 95% confidence interval [CI] = 1.04-1.40) or late age at menarche (≥14y, HR = 1.18, 95% CI = 1.03-1.35) than in women with menarche at 12-13y. Nulliparity was not associated with Parkinson disease, but Parkinson disease incidence increased with the number of children in parous women (P-trend = 0.009). Women with artificial (surgical, iatrogenic) menopause were at greater risk than women with natural menopause (HR = 1.28, 95% CI = 1.09-1.47), especially when artificial menopause occurred at an early age (≤45.0 years). Postmenopausal hormone therapy tended to mitigate greater risk associated with artificial or early menopause (≤45.0 years). While fertility treatments were not associated with Parkinson disease overall, ever users of clomiphene were at greater Parkinson disease risk than never users (HR = 1.81, 95% CI = 1.14-2.88). Other exposures (breastfeeding, oral contraceptives) were not associated with Parkinson disease. Our findings suggest that early and late age at menarche, higher parity, and artificial menopause, in particular at an early age, are associated with increased Parkinson disease incidence in women. In addition, there was some evidence that use of exogenous hormones may increase (fertility treatments) or decrease (postmenopausal hormone therapy) Parkinson disease incidence. These findings support the hypothesis that hormonal exposures play a role in the susceptibility to neurodegenerative diseases. If confirmed, they could help to identify subgroups at high risk for Parkinson disease. [ABSTRACT FROM AUTHOR]
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- 2023
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226. Exposure to Ambient Air Pollution and the Risk of Inflammatory Bowel Disease: A European Nested Case–Control Study
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Opstelten, Jorrit L., Beelen, Rob M. J., Leenders, Max, Hoek, Gerard, Brunekreef, Bert, van Schaik, Fiona D. M., Siersema, Peter D., Eriksen, Kirsten T., Raaschou-Nielsen, Ole, Tjønneland, Anne, Overvad, Kim, Boutron-Ruault, Marie-Christine, Carbonnel, Franck, de Hoogh, Kees, Key, Timothy J., Luben, Robert, Chan, Simon S. M., Hart, Andrew R., Bueno-de-Mesquita, H. Bas, and Oldenburg, Bas
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- 2016
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227. Consumption of soft drinks and juices and risk of liver and biliary tract cancers in a European cohort
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Stepien, Magdalena, Duarte-Salles, Talita, Fedirko, Veronika, Trichopoulou, Antonia, Lagiou, Pagona, Bamia, Christina, Overvad, Kim, Tjønneland, Anne, Hansen, Louise, Boutron-Ruault, Marie-Christine, Fagherazzi, Guy, Severi, Gianluca, Kühn, Tilman, Kaaks, Rudolf, Aleksandrova, Krasimira, Boeing, Heiner, Klinaki, Eleni, Palli, Domenico, Grioni, Sara, Panico, Salvatore, Tumino, Rosario, Naccarati, Alessio, Bueno-de-Mesquita, H. Bas, Peeters, Petra H., Skeie, Guri, Weiderpass, Elisabete, Parr, Christine L., Quirós, José Ramón, Buckland, Genevieve, Molina-Montes, Esther, Amiano, Pilar, Chirlaque, Maria-Dolores, Ardanaz, Eva, Sonestedt, Emily, Ericson, Ulrika, Wennberg, Maria, Nilsson, Lena Maria, Khaw, Kay-Tee, Wareham, Nick, Bradbury, Kathryn E., Ward, Heather A., Romieu, Isabelle, and Jenab, Mazda
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- 2016
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228. Baseline and lifetime alcohol consumption and risk of skin cancer in the European Prospective Investigation into Cancer and Nutrition cohort ( EPIC )
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Mahamat‐Saleh, Yahya, primary, Al‐Rahmoun, Marie, additional, Severi, Gianluca, additional, Ghiasvand, Reza, additional, Veierod, Marit B., additional, Caini, Saverio, additional, Palli, Domenico, additional, Botteri, Edoardo, additional, Sacerdote, Carlotta, additional, Ricceri, Fulvio, additional, Lukic, Marko, additional, Sánchez, Maria J., additional, Pala, Valeria, additional, Tumino, Rosario, additional, Chiodini, Paolo, additional, Amiano, Pilar, additional, Colorado‐Yohar, Sandra, additional, Chirlaque, María‐Dolores, additional, Ardanaz, Eva, additional, Bonet, Catalina, additional, Katzke, Verena, additional, Kaaks, Rudolf, additional, Schulze, Matthias B., additional, Overvad, Kim, additional, Dahm, Christina C., additional, Antoniussen, Christian S., additional, Tjønneland, Anne, additional, Kyrø, Cecilie, additional, Bueno‐de‐Mesquita, Bas, additional, Manjer, Jonas, additional, Jansson, Malin, additional, Esberg, Anders, additional, Mori, Nagisa, additional, Ferrari, Pietro, additional, Weiderpass, Elisabete, additional, Boutron‐Ruault, Marie‐Christine, additional, and Kvaskoff, Marina, additional
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- 2022
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229. Sweetened beverages are associated with a higher risk of differentiated thyroid cancer in the EPIC cohort: a dietary pattern approach
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Zamora-Ros, Raul, primary, Cayssials, Valerie, additional, Clèries, Ramon, additional, Torrents, Maria, additional, Byrnes, Graham, additional, Weiderpass, Elisabete, additional, Sandström, Maria, additional, Almquist, Martin, additional, Boutron-Ruault, Marie-Christine, additional, Tjønneland, Anne, additional, Kyrø, Cecilie, additional, Katzke, Verena A., additional, Le Cornet, Charlotte, additional, Masala, Giovanna, additional, Krogh, Vittorio, additional, Iannuzzo, Gabriella, additional, Tumino, Rosario, additional, Milani, Lorenzo, additional, Skeie, Guri, additional, Ubago-Guisado, Esther, additional, Amiano, Pilar, additional, Chirlaque, María-Dolores, additional, Ardanaz, Eva, additional, Janzi, Suzanne, additional, Eriksson, Linda, additional, Freisling, Heinz, additional, Heath, Alicia K., additional, Rinaldi, Sabina, additional, and Agudo, Antonio, additional
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- 2022
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230. Response to Boonpor et al: Types of diet, obesity, and incident type 2 diabetes: Findings from the UK Biobank prospective cohort study
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MacDonald, Conor James, primary, Frenoy, Pauline, additional, and Boutron‐Ruault, Marie‐Christine, additional
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- 2022
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231. Delayed-release oral mesalamine tablet mimicking a small jejunal gastrointestinal stromal tumor: A case report
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Frosio, Fabio, primary, Rausa, Emanuele, additional, Marra, Paolo, additional, Boutron-Ruault, Marie-Christine, additional, and Lucianetti, Alessandro, additional
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- 2022
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232. Long-term Air Pollution Exposure and Pneumonia-related Mortality in a Large Pooled European Cohort
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Liu, Shuo, primary, Lim, Youn-Hee, additional, Chen, Jie, additional, Strak, Maciek, additional, Wolf, Kathrin, additional, Weinmayr, Gudrun, additional, Rodopolou, Sophia, additional, de Hoogh, Kees, additional, Bellander, Tom, additional, Brandt, Jørgen, additional, Concin, Hans, additional, Zitt, Emanuel, additional, Fecht, Daniela, additional, Forastiere, Francesco, additional, Gulliver, John, additional, Hertel, Ole, additional, Hoffmann, Barbara, additional, Hvidtfeldt, Ulla A., additional, Verschuren, W. M. Monique, additional, Jöckel, Karl-Heinz, additional, Jørgensen, Jeanette T., additional, So, Rina, additional, Amini, Heresh, additional, Cole-Hunter, Thomas, additional, Mehta, Amar J., additional, Mortensen, Laust H., additional, Ketzel, Matthias, additional, Lager, Anton, additional, Leander, Karin, additional, Ljungman, Petter, additional, Severi, Gianluca, additional, Boutron-Ruault, Marie-Christine, additional, Magnusson, Patrik K. E., additional, Nagel, Gabriele, additional, Pershagen, Göran, additional, Peters, Annette, additional, Raaschou-Nielsen, Ole, additional, Rizzuto, Debora, additional, van der Schouw, Yvonne T., additional, Schramm, Sara, additional, Sørensen, Mette, additional, Stafoggia, Massimo, additional, Tjønneland, Anne, additional, Katsouyanni, Klea, additional, Huang, Wei, additional, Samoli, Evangelia, additional, Brunekreef, Bert, additional, Hoek, Gerard, additional, and Andersen, Zorana J., additional
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- 2022
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233. Adherence to Healthy and Unhealthy Plant-Based Diets and Risk of Breast Cancer Overall and by Hormone Receptor and Histologic Subtypes Among Postmenopausal Women
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Shah, Sanam, primary, Mahamat-Saleh, Yahya, additional, Ait-Hadad, Wassila, additional, Varraso, Raphaëlle, additional, Boutron-Ruault, Marie-Christine, additional, and Laouali, Nasser, additional
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- 2022
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234. Intake of Coffee, Decaffeinated Coffee, or Tea Does Not Affect Risk for Pancreatic Cancer: Results From the European Prospective Investigation into Nutrition and Cancer Study
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Bhoo–Pathy, Nirmala, Uiterwaal, Cuno S.P.M., Dik, Vincent K., Jeurnink, Suzanne M., Bech, Bodil H., Overvad, Kim, Halkjær, Jytte, Tjønneland, Anne, Boutron–Ruault, Marie–Christine, Fagherazzi, Guy, Racine, Antoine, Katzke, Verena A., Li, Kuanrong, Boeing, Heiner, Floegel, Anna, Androulidaki, Anna, Bamia, Christina, Trichopoulou, Antonia, Masala, Giovanna, Panico, Salvatore, Crosignani, Paolo, Tumino, Rosario, Vineis, Paolo, Peeters, Petra H.M., Gavrilyuk, Oxana, Skeie, Guri, Weiderpass, Elisabete, Duell, Eric J., Arguelles, Marcial, Molina–Montes, Esther, Navarro, Carmen, Ardanaz, Eva, Dorronsoro, Miren, Lindkvist, Björn, Wallström, Peter, Sund, Malin, Ye, Weimin, Khaw, Kay–Tee, Wareham, Nick, Key, Timothy J., Travis, Ruth C., Duarte–Salles, Talita, Freisling, Heinz, Licaj, Idlir, Gallo, Valentina, Michaud, Dominique S., Riboli, Elio, and Bueno–De–Mesquita, H. Bas
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- 2013
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235. Lifestyle, dietary factors, and antibody levels to oral bacteria in cancer-free participants of a European cohort study
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Michaud, Dominique S., Izard, Jacques, Rubin, Zachary, Johansson, Ingegerd, Weiderpass, Elisabete, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Boutron-Ruault, Marie Christine, Clavel-Chapelon, Françoise, Dossus, Laure, Kaaks, Rudolf, Katzke, Verena A., Boeing, Heiner, Foerster, Jana, Trichopoulou, Antonia, Naska, Androniki, Ziara, Giana, Vineis, Paolo, Grioni, Sara, Palli, Domenico, Tumino, Rosario, Mattiello, Amalia, Peeters, Petra H. M., Siersema, Peter D., Barricarte, Aurelio, Huerta, José-María, Molina-Montes, Esther, Dorronsoro, Miren, Quirós, J. Ramón, Duell, Eric J., Ohlsson, Bodil, Jeppsson, Bengt, Johansson, Anders, Lif, Pernilla, Khaw, Kay-Tee, Wareham, Nick, Travis, Ruth C., Key, Tim J., Freisling, Heinz, Duarte-Salles, Talita, Stepien, Magdalena, Riboli, Elio, and Bueno-de-Mesquita, H. Bas
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- 2013
236. Childhood and Adolescent Exposures and the Risk of Endometriosis
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Kvaskoff, Marina, Bijon, Anne, Clavel-Chapelon, Françoise, Mesrine, Sylvie, and Boutron-Ruault, Marie-Christine
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- 2013
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237. Polymorphisms in genes related to one-carbon metabolism are not related to pancreatic cancer in PanScan and PanC4
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Leenders, Max, Bhattacharjee, Samsiddhi, Vineis, Paolo, Stevens, Victoria, Bueno-de-Mesquita, H. Bas, Shu, Xiao-Ou, Amundadottir, Laufey, Gross, Myron, Tobias, Geoffrey S., Wactawski-Wende, Jean, Arslan, Alan A., Duell, Eric J., Fuchs, Charles S., Gallinger, Steven, Hartge, Patricia, Hoover, Robert N., Holly, Elizabeth A., Jacobs, Eric J., Klein, Alison P., Kooperberg, Charles, LaCroix, Andrea, Li, Donghui, Mandelson, Margaret T., Olson, Sara H., Petersen, Gloria, Risch, Harvey A., Yu, Kai, Wolpin, Brian M., Zheng, Wei, Agalliu, Ilir, Albanes, Demetrius, Boutron-Ruault, Marie-Christine, Bracci, Paige M., Buring, Julie E., Canzian, Federico, Chang, Kenneth, Chanock, Stephen J., Cotterchio, Michelle, Gaziano, J. Michael, Giovanucci, Edward L., Goggins, Michael, Hallmans, Göran, Hankinson, Susan E., Hoffman-Bolton, Judith A., Hunter, David J., Hutchinson, Amy, Jacobs, Kevin B., Jenab, Mazda, Khaw, Kay-Tee, Kraft, Peter, Krogh, Vittorio, Kurtz, Robert C., McWilliams, Robert R., Mendelsohn, Julie B., Patel, Alpa V., Rabe, Kari G., Riboli, Elio, Tjønneland, Anne, Trichopoulos, Dimitrios, Virtamo, Jarmo, Visvanathan, Kala, Elena, Joanne W., Yu, Herbert, Zeleniuch-Jacquotte, Anne, and Stolzenberg-Solomon, Rachael Z.
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- 2013
238. Body shape throughout life and the risk for breast cancer at adulthood in the French E3N cohort
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Fagherazzi, Guy, Guillas, Gwenaelle, Boutron-Ruault, Marie-Christine, Clavel-Chapelon, Françoise, and Mesrine, Sylvie
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- 2013
239. A structural equation modelling approach to explore the role of B vitamins and immune markers in lung cancer risk
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Baltar, Valéria Troncoso, Xun, Wei W., Johansson, Mattias, Ferrari, Pietro, Chuang, Shu-Chun, Relton, Caroline, Ueland, Per Magne, Midttun, Øivind, Slimani, Nadia, Jenab, Mazda, Clavel-Chapeìon, Françoise, Boutron-Ruault, Marie-Christine, Fagherazzi, Guy, Kaaks, Rudolf, Rohrmann, Sabine, Boeing, Heiner, Weikert, Cornelia, Bueno-de-Mesquita, Bas, Boshuizen, Hendriek, van Gils, Caria H., Onland-Moret, N. Charlotte, Agudo, Antonio, Barricarte, Aurelio, Navarro, Carmen, Rodriguez, Laudina, Castaño, José Maria Huerta, Larrañaga, Nerea, Khaw, Kay-Tee, Wareham, Nick, Allen, Naomi E., Crowe, Francesca, Gallo, Valentina, Norat, Teresa, Krogh, Vittorio, Masala, Giovanna, Panico, Salvatore, Sacerdote, Carlotta, Tumino, Rosario, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Rasmuson, Torgny, Hallmans, Göran, Roswall, Nina, Tjønneland, Anne, Riboli, Elio, Brennan, Paul, and Vineis, Paolo
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- 2013
240. Mediterranean diet and colorectal cancer risk: results from a European cohort
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Bamia, Christina, Lagiou, Pagona, Buckland, Genevieve, Grioni, Sara, Agnoli, Claudia, Taylor, Aliki J., Dahm, Christina C., Overvad, Kim, Olsen, Anja, Tjønneland, Anne, Cottet, Vanessa, Boutron-Ruault, Marie-Christine, Morois, Sophie, Grote, Verena, Teucher, Birgit, Boeing, Heiner, Buijsse, Brian, Trichopoulos, Dimitrios, Adarakis, George, Tumino, Rosario, Naccarati, Alessio, Panico, Salvatore, Palli, Domenico, Bueno-de-Mesquita, H. Bas, van Duijnhoven, Fränzel J. B., Peeters, Petra H. M., Engeset, Dagrun, Skeie, Guri, Lund, Eiliv, Sánchez, Maria-José, Barricarte, Aurelio, Huerta, Jose-Maria, Quirós, J. Ramón, Dorronsoro, Miren, Ljuslinder, Ingrid, Palmqvist, Richard, Drake, Isabel, Key, Timothy J., Khaw, Kay-Tee, Wareham, Nick, Romieu, Isabelle, Fedirko, Veronika, Jenab, Mazda, Romaguera, Dora, Norat, Teresa, and Trichopoulou, Antonia
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- 2013
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241. Diabetes and risk of pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortium
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Elena, Joanne W., Steplowski, Emily, Yu, Kai, Hartge, Patricia, Tobias, Geoffrey S., Brotzman, Michelle J., Chanock, Stephen J., Stolzenberg-Solomon, Rachael Z., Arslan, Alan A., Bueno-de-Mesquita, H. Bas, Helzlsouer, Kathy, Jacobs, Eric J., LaCroix, Andrea, Petersen, Gloria, Zheng, Wei, Albanes, Demetrius, Allen, Naomi E., Amundadottir, Laufey, Bao, Ying, Boeing, Heiner, Boutron-Ruault, Marie-Christine, Buring, Julie E., Gaziano, J. Michael, Giovannucci, Edward L., Duell, Eric J., Hallmans, Göran, Howard, Barbara V., Hunter, David J., Hutchinson, Amy, Jacobs, Kevin B., Kooperberg, Charles, Kraft, Peter, Mendelsohn, Julie B., Michaud, Dominique S., Palli, Domenico, Phillips, Lawrence S., Overvad, Kim, Patel, Alpa V., Sansbury, Leah, Shu, Xiao–Ou, Simon, Michael S., Slimani, Nadia, Trichopoulos, Dimitrios, Visvanathan, Kala, Virtamo, Jarmo, Wolpin, Brian M., Zeleniuch-Jacquotte, Anne, Fuchs, Charles S., Hoover, Robert N., and Gross, Myron
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- 2013
242. Plasma concentrations of persistent organic pollutants and pancreatic cancer risk
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Porta, Miquel, Gasull, M., Pumarega, J., Kiviranta, Hannu, Rantakokko, Panu, Raaschou-Nielsen, Ole, Bergdahl, Ingvar A, Sandanger, Torkjel Manning, Agudo, Antonio, Rylander, Charlotta, Nøst, Therese Haugdahl, Aune, Dagfinn, Heath, A.K., Cirera, Lluis, Goñi-Irigoyen, Fernando, Alguacil, Juan, Gimenez-Robert, Alex, Tjonneland, Anne, Sund, Malin, Overvad, Kim, Mancini, Francesca Romana, Rebours, V., Boutron-Ruault, Marie Christine, Kaaks, Rudolf, Schulze, M.B., Trichopoulou, Antonia, Palli, Domenico, Grioni, Sara, Tumino, Rosario, Naccarati, Alessio, Panico, Salvatore, Vermeulen, Roel, Quiros, J.R., Rodriguez-Barranco, Miguel, Colorado-Yohar, Sandra, Chirlaque, Maria Dolores, Ardanaz, Eva, Wareham, Nick J, Key, Timothy, Johansson, Mattias, Murphy, Neil, Ferrari, Pietro, Huybrechts, Inge, Chajes, V., González, Carlos A., Bas Bueno-de-Mesquita, Bas Bueno-de-Mesquita, Gunter, M.J., Weiderpass, Elisabete, Riboli, Elio, Duell, Eric J., Katzke, Verena, Vineis, Paolo, and IRAS OH Epidemiology Chemical Agents
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biomarkers ,environmental health ,Pancreatic cancer ,persistent organic pollutants ,methods - Abstract
Background: Findings and limitations of previous studies on persistent organic pollutants (POPs) and pancreatic cancer risk support conducting further research in prospective cohorts. Methods: We conducted a prospective case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Participants were 513 pancreatic cancer cases and 1020 matched controls. Concentrations of 22 POPs were measured in plasma collected at baseline. Results: Some associations were observed at higher concentrations of p, p'-DDT, trans-nonachlor, β-hexachlorocyclohexane and the sum of six organochlorine pesticides and of 16 POPs. The odds ratio (OR) for the upper quartile of trans-nonachlor was 1.55 (95% confidence interval 1.06-2.26; P for trend = 0.025). Associations were stronger in the groups predefined as most valid (participants having fasted >6 h, with microscopic diagnostic confirmation, normal weight, and never smokers), and as most relevant (follow-up ≥10 years). Among participants having fasted >6 h, the ORs were relevant for 10 of 11 exposures. Higher ORs were also observed among cases with microscopic confirmation than in cases with a clinical diagnosis, and among normal-weight participants than in the rest of participants. Among participants with a follow-up ≥10 years, estimates were higher than in participants with a shorter follow-up (for trans-nonachlor: OR = 2.14, 1.01 to 4.53, P for trend = 0.035). Overall, trans-nonachlor, three PCBs and the two sums of POPs were the exposures most clearly associated with pancreatic cancer risk. Conclusions: Individually or in combination, most of the 22 POPs analysed did not or only moderately increased the risk of pancreatic cancer.
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- 2022
243. Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for 13 Cancer Types
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Sampson, Joshua N., Wheeler, William A., Yeager, Meredith, Panagiotou, Orestis, Wang, Zhaoming, Berndt, Sonja I., Lan, Qing, Abnet, Christian C., Amundadottir, Laufey T., Figueroa, Jonine D., Landi, Maria Teresa, Mirabello, Lisa, Savage, Sharon A., Taylor, Philip R., Vivo, Immaculata De, McGlynn, Katherine A., Purdue, Mark P., Rajaraman, Preetha, Adami, Hans-Olov, Ahlbom, Anders, Albanes, Demetrius, Amary, Maria Fernanda, An, She-Juan, Andersson, Ulrika, Andriole, Gerald, Jr., Andrulis, Irene L., Angelucci, Emanuele, Ansell, Stephen M., Arici, Cecilia, Armstrong, Bruce K., Arslan, Alan A., Austin, Melissa A., Baris, Dalsu, Barkauskas, Donald A., Bassig, Bryan A., Becker, Nikolaus, Benavente, Yolanda, Benhamou, Simone, Berg, Christine, Van Den Berg, David, Bernstein, Leslie, Bertrand, Kimberly A., Birmann, Brenda M., Black, Amanda, Boeing, Heiner, Boffetta, Paolo, Boutron-Ruault, Marie-Christine, Bracci, Paige M., Brinton, Louise, Brooks-Wilson, Angela R., Bueno-de-Mesquita, H. Bas, Burdett, Laurie, Buring, Julie, Butler, Mary Ann, Cai, Qiuyin, Cancel-Tassin, Geraldine, Canzian, Federico, Carrato, Alfredo, Carreon, Tania, Carta, Angela, Chan, John K. C., Chang, Ellen T., Chang, Gee-Chen, Chang, I-Shou, Chang, Jiang, Chang-Claude, Jenny, Chen, Chien-Jen, Chen, Chih-Yi, Chen, Chu, Chen, Chung-Hsing, Chen, Constance, Chen, Hongyan, Chen, Kexin, Chen, Kuan-Yu, Chen, Kun-Chieh, Chen, Ying, Chen, Ying-Hsiang, Chen, Yi-Song, Chen, Yuh-Min, Chien, Li-Hsin, Chirlaque, María-Dolores, Choi, Jin Eun, Choi, Yi Young, Chow, Wong-Ho, Chung, Charles C., Clavel, Jacqueline, Clavel-Chapelon, Françoise, Cocco, Pierluigi, Colt, Joanne S., Comperat, Eva, Conde, Lucia, Connors, Joseph M., Conti, David, Cortessis, Victoria K., Cotterchio, Michelle, Cozen, Wendy, Crouch, Simon, Crous-Bou, Marta, Cussenot, Olivier, Davis, Faith G., Ding, Ti, Diver, W. Ryan, Dorronsoro, Miren, Dossus, Laure, Duell, Eric J., Ennas, Maria Grazia, Erickson, Ralph L., Feychting, Maria, Flanagan, Adrienne M., Foretova, Lenka, Fraumeni, Joseph F., Jr, Freedman, Neal D., Beane Freeman, Laura E., Fuchs, Charles, Gago-Dominguez, Manuela, Gallinger, Steven, Gao, Yu-Tang, Gapstur, Susan M., Garcia-Closas, Montserrat, García-Closas, Reina, Gascoyne, Randy D., Gastier-Foster, Julie, Gaudet, Mia M., Gaziano, J. Michael, Giffen, Carol, Giles, Graham G., Giovannucci, Edward, Glimelius, Bengt, Goggins, Michael, Gokgoz, Nalan, Goldstein, Alisa M., Gorlick, Richard, Gross, Myron, Grubb, Robert, III, Gu, Jian, Guan, Peng, Gunter, Marc, Guo, Huan, Habermann, Thomas M., Haiman, Christopher A., Halai, Dina, Hallmans, Goran, Hassan, Manal, Hattinger, Claudia, He, Qincheng, He, Xingzhou, Helzlsouer, Kathy, Henderson, Brian, Henriksson, Roger, Hjalgrim, Henrik, Hoffman-Bolton, Judith, Hohensee, Chancellor, Holford, Theodore R., Holly, Elizabeth A., Hong, Yun-Chul, Hoover, Robert N., Horn-Ross, Pamela L., Hosain, G. M. Monawar, Hosgood, H. Dean, III, Hsiao, Chin-Fu, Hu, Nan, Hu, Wei, Hu, Zhibin, Huang, Ming-Shyan, Huerta, Jose-Maria, Hung, Jen-Yu, Hutchinson, Amy, Inskip, Peter D., Jackson, Rebecca D., Jacobs, Eric J., Jenab, Mazda, Jeon, Hyo-Sung, Ji, Bu-Tian, Jin, Guangfu, Jin, Li, Johansen, Christoffer, Johnson, Alison, Jung, Yoo Jin, Kaaks, Rudolph, Kamineni, Aruna, Kane, Eleanor, Kang, Chang Hyun, Karagas, Margaret R., Kelly, Rachel S., Khaw, Kay-Tee, Kim, Christopher, Kim, Hee Nam, Kim, Jin Hee, Kim, Jun Suk, Kim, Yeul Hong, Kim, Young Tae, Kim, Young-Chul, Kitahara, Cari M., Klein, Alison P., Klein, Robert J., Kogevinas, Manolis, Kohno, Takashi, Kolonel, Laurence N., Kooperberg, Charles, Kricker, Anne, Krogh, Vittorio, Kunitoh, Hideo, Kurtz, Robert C., Kweon, Sun-Seog, LaCroix, Andrea, Lawrence, Charles, Lecanda, Fernando, Lee, Victor Ho Fun, Li, Donghui, Li, Haixin, Li, Jihua, Li, Yao-Jen, Li, Yuqing, Liao, Linda M., Liebow, Mark, Lightfoot, Tracy, Lim, Wei-Yen, Lin, Chien-Chung, Lin, Dongxin, Lindstrom, Sara, Linet, Martha S., Link, Brian K., Liu, Chenwei, Liu, Jianjun, Liu, Li, Ljungberg, Börje, Lloreta, Josep, Lollo, Simonetta Di, Lu, Daru, Lund, Eiluv, Malats, Nuria, Mannisto, Satu, Marchand, Loic Le, Marina, Neyssa, Masala, Giovanna, Mastrangelo, Giuseppe, Matsuo, Keitaro, Maynadie, Marc, McKay, James, McKean-Cowdin, Roberta, Melbye, Mads, Melin, Beatrice S., Michaud, Dominique S., Mitsudomi, Tetsuya, Monnereau, Alain, Montalvan, Rebecca, Moore, Lee E., Mortensen, Lotte Maxild, Nieters, Alexandra, North, Kari E., Novak, Anne J., Oberg, Ann L., Offit, Kenneth, Oh, In-Jae, Olson, Sara H., Palli, Domenico, Pao, William, Park, In Kyu, Park, Jae Yong, Park, Kyong Hwa, Patiño-Garcia, Ana, Pavanello, Sofia, Peeters, Petra H. M., Perng, Reury-Perng, Peters, Ulrike, Petersen, Gloria M., Picci, Piero, Pike, Malcolm C., Porru, Stefano, Prescott, Jennifer, Prokunina-Olsson, Ludmila, Qian, Biyun, Qiao, You-Lin, Rais, Marco, Riboli, Elio, Riby, Jacques, Risch, Harvey A., Rizzato, Cosmeri, Rodabough, Rebecca, Roman, Eve, Roupret, Morgan, Ruder, Avima M., Sanjose, Silvia de, Scelo, Ghislaine, Schned, Alan, Schumacher, Fredrick, Schwartz, Kendra, Schwenn, Molly, Scotlandi, Katia, Seow, Adeline, Serra, Consol, Serra, Massimo, Sesso, Howard D., Setiawan, Veronica Wendy, Severi, Gianluca, Severson, Richard K., Shanafelt, Tait D., Shen, Hongbing, Shen, Wei, Shin, Min-Ho, Shiraishi, Kouya, Shu, Xiao-Ou, Siddiq, Afshan, Sierrasesúmaga, Luis, Sihoe, Alan Dart Loon, Skibola, Christine F., Smith, Alex, Smith, Martyn T., Southey, Melissa C., Spinelli, John J., Staines, Anthony, Stampfer, Meir, Stern, Marianna C., Stevens, Victoria L., Stolzenberg-Solomon, Rachael S., Su, Jian, Su, Wu-Chou, Sund, Malin, Sung, Jae Sook, Sung, Sook Whan, Tan, Wen, Tang, Wei, Tardón, Adonina, Thomas, David, Thompson, Carrie A., Tinker, Lesley F., Tirabosco, Roberto, Tjønneland, Anne, Travis, Ruth C., Trichopoulos, Dimitrios, Tsai, Fang-Yu, Tsai, Ying-Huang, Tucker, Margaret, Turner, Jenny, Vajdic, Claire M., Vermeulen, Roel C. H., Villano, Danylo J., Vineis, Paolo, Virtamo, Jarmo, Visvanathan, Kala, Wactawski-Wende, Jean, Wang, Chaoyu, Wang, Chih-Liang, Wang, Jiu-Cun, Wang, Junwen, Wei, Fusheng, Weiderpass, Elisabete, Weiner, George J., Weinstein, Stephanie, Wentzensen, Nicolas, White, Emily, Witzig, Thomas E., Wolpin, Brian M., Wong, Maria Pik, Wu, Chen, Wu, Guoping, Wu, Junjie, Wu, Tangchun, Wu, Wei, Wu, Xifeng, Wu, Yi-Long, Wunder, Jay S., Xiang, Yong-Bing, Xu, Jun, Xu, Ping, Yang, Pan-Chyr, Yang, Tsung-Ying, Ye, Yuanqing, Yin, Zhihua, Yokota, Jun, Yoon, Ho-Il, Yu, Chong-Jen, Yu, Herbert, Yu, Kai, Yuan, Jian-Min, Zelenetz, Andrew, Zeleniuch-Jacquotte, Anne, Zhang, Xu-Chao, Zhang, Yawei, Zhao, Xueying, Zhao, Zhenhong, Zheng, Hong, Zheng, Tongzhang, Zheng, Wei, Zhou, Baosen, Zhu, Meng, Zucca, Mariagrazia, Boca, Simina M., Cerhan, James R., Ferri, Giovanni M., Hartge, Patricia, Hsiung, Chao Agnes, Magnani, Corrado, Miligi, Lucia, Morton, Lindsay M., Smedby, Karin E., Teras, Lauren R., Vijai, Joseph, Wang, Sophia S., Brennan, Paul, Caporaso, Neil E., Hunter, David J., Kraft, Peter, Rothman, Nathaniel, Silverman, Debra T., Slager, Susan L., Chanock, Stephen J., and Chatterjee, Nilanjan
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- 2015
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244. Long-term exposure to ambient air pollution and bladder cancer incidence in a pooled European cohort : the ELAPSE project
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Chen, Jie, Rodopoulou, Sophia, Strak, Maciej, de Hoogh, Kees, Taj, Tahir, Poulsen, Aslak Harbo, Andersen, Zorana J., Bellander, Tom, Brandt, Jørgen, Zitt, Emanuel, Fecht, Daniela, Forastiere, Francesco, Gulliver, John, Hertel, Ole, Hoffmann, Barbara, Hvidtfeldt, Ulla Arthur, Verschuren, W. M. Monique, Jørgensen, Jeanette T., Katsouyanni, Klea, Ketzel, Matthias, Lager, Anton, Leander, Karin, Liu, Shuo, Ljungman, Petter, Severi, Gianluca, Boutron-Ruault, Marie-Christine, Magnusson, Patrik K. E., Nagel, Gabriele, Pershagen, Göran, Peters, Annette, Rizzuto, Debora, van der Schouw, Yvonne T., Samoli, Evangelia, Sørensen, Mette, Stafoggia, Massimo, Tjønneland, Anne, Weinmayr, Gudrun, Wolf, Kathrin, Brunekreef, Bert, Raaschou-Nielsen, Ole, Hoek, Gerard, Chen, Jie, Rodopoulou, Sophia, Strak, Maciej, de Hoogh, Kees, Taj, Tahir, Poulsen, Aslak Harbo, Andersen, Zorana J., Bellander, Tom, Brandt, Jørgen, Zitt, Emanuel, Fecht, Daniela, Forastiere, Francesco, Gulliver, John, Hertel, Ole, Hoffmann, Barbara, Hvidtfeldt, Ulla Arthur, Verschuren, W. M. Monique, Jørgensen, Jeanette T., Katsouyanni, Klea, Ketzel, Matthias, Lager, Anton, Leander, Karin, Liu, Shuo, Ljungman, Petter, Severi, Gianluca, Boutron-Ruault, Marie-Christine, Magnusson, Patrik K. E., Nagel, Gabriele, Pershagen, Göran, Peters, Annette, Rizzuto, Debora, van der Schouw, Yvonne T., Samoli, Evangelia, Sørensen, Mette, Stafoggia, Massimo, Tjønneland, Anne, Weinmayr, Gudrun, Wolf, Kathrin, Brunekreef, Bert, Raaschou-Nielsen, Ole, and Hoek, Gerard
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Background: The evidence linking ambient air pollution to bladder cancer is limited and mixed. Methods: We assessed the associations of bladder cancer incidence with residential exposure to fine particles (PM2.5), nitrogen dioxide (NO2), black carbon (BC), warm season ozone (O3) and eight PM2.5 elemental components (copper, iron, potassium, nickel, sulfur, silicon, vanadium, and zinc) in a pooled cohort (N = 302,493). Exposures were primarily assessed based on 2010 measurements and back-extrapolated to the baseline years. We applied Cox proportional hazard models adjusting for individual- and area-level potential confounders. Results: During an average of 18.2 years follow-up, 967 bladder cancer cases occurred. We observed a positive though statistically non-significant association between PM2.5 and bladder cancer incidence. Hazard Ratios (HR) were 1.09 (95% confidence interval (CI): 0.93–1.27) per 5 µg/m3 for 2010 exposure and 1.06 (95% CI: 0.99–1.14) for baseline exposure. Effect estimates for NO2, BC and O3 were close to unity. A positive association was observed with PM2.5 zinc (HR 1.08; 95% CI: 1.00–1.16 per 10 ng/m3). Conclusions: We found suggestive evidence of an association between long-term PM2.5 mass exposure and bladder cancer, strengthening the evidence from the few previous studies. The association with zinc in PM2.5 suggests the importance of industrial emissions.
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- 2022
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245. Adherence to mediterranean diet and the risk of differentiated thyroid cancer in a European cohort : the EPIC study
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Llaha, Fjorida, Cayssials, Valerie, Farràs, Marta, Agudo, Antonio, Sandström, Maria, Eriksen, Anne Kirstine, Tjønneland, Anne, Boutron-Ruault, Marie-Christine, Laouali, Nasser, Truong, Thérèse, Le Cornet, Charlotte, Katzke, Verena, Schulze, Matthias, Palli, Domenico, Krogh, Vittorio, Signoriello, Simona, Tumino, Rosario, Ricceri, Fulvio, Skeie, Guri, Jensen, Torill Miriam Enget, Chen, Sairah Lai Fa, Lasheras, Cristina, Rodriguez-Barranco, Miguel, Amiano, Pilar, Huerta, José María, Guevara, Marcela, Almquist, Martin, Nilsson, Lena Maria, Hennings, Joakim, Papier, Keren, Heath, Alicia, Weiderpass, Elisabete, Rinaldi, Sabina, Zamora-Ros, Raul, Llaha, Fjorida, Cayssials, Valerie, Farràs, Marta, Agudo, Antonio, Sandström, Maria, Eriksen, Anne Kirstine, Tjønneland, Anne, Boutron-Ruault, Marie-Christine, Laouali, Nasser, Truong, Thérèse, Le Cornet, Charlotte, Katzke, Verena, Schulze, Matthias, Palli, Domenico, Krogh, Vittorio, Signoriello, Simona, Tumino, Rosario, Ricceri, Fulvio, Skeie, Guri, Jensen, Torill Miriam Enget, Chen, Sairah Lai Fa, Lasheras, Cristina, Rodriguez-Barranco, Miguel, Amiano, Pilar, Huerta, José María, Guevara, Marcela, Almquist, Martin, Nilsson, Lena Maria, Hennings, Joakim, Papier, Keren, Heath, Alicia, Weiderpass, Elisabete, Rinaldi, Sabina, and Zamora-Ros, Raul
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Background: The Mediterranean diet (MD) has been proposed as a healthy diet with a potential to lower the incidence of several types of cancer, but there is no data regarding thyroid cancer (TC). We investigated the association between MD adherence, and its components, and the differentiated TC risk within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods: Over 450,000 men and women from nine European countries were followed up for a mean of 14.1 years, during which 712 differentiated TC cases were identified. Adherence to MD was estimated using the relative MD (rMED) score, an 18-point scale including alcohol, and the adapted rMED (arMED) score, a 16-point scale excluding alcohol. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox regression models adjusted for potential confounding factors. Results: Adherence to the arMED score was not associated with the risk of differentiated TC (HRhigh vs. low adherence = 0.94, 95% CI: 0.70–1.25; p-trend 0.27), while a suggestive, but non-statistically significant inverse relationship was observed with rMED (HRhigh vs. low adherence = 0.88, 95% CI: 0.68–1.14; p-trend 0.17). Low meat (HRlow vs. high meat intake = 0.81, 95% CI: 0.67–0.99; p-trend = 0.04) and moderate alcohol (HRmoderate vs. non−moderate intake = 0.88, 95% CI: 0.75–1.03) intake were related with lower differentiated TC risk. Conclusions: Our study shows that a high adherence to MD is not strongly related to differentiated TC risk, although further research is required to confirm the impact of MD and, especially, meat intake in TC risk.
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- 2022
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246. Sweetened beverages are associated with a higher risk of differentiated thyroid cancer in the EPIC cohort : a dietary pattern approach
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Zamora-Ros, Raul, Cayssials, Valerie, Clèries, Ramon, Torrents, Maria, Byrnes, Graham, Weiderpass, Elisabete, Sandström, Maria, Almquist, Martin, Boutron-Ruault, Marie-Christine, Tjønneland, Anne, Kyrø, Cecilie, Katzke, Verena A., Le Cornet, Charlotte, Masala, Giovanna, Krogh, Vittorio, Iannuzzo, Gabriella, Tumino, Rosario, Milani, Lorenzo, Skeie, Guri, Ubago-Guisado, Esther, Amiano, Pilar, Chirlaque, María-Dolores, Ardanaz, Eva, Janzi, Suzanne, Eriksson, Linda, Freisling, Heinz, Heath, Alicia K., Rinaldi, Sabina, Agudo, Antonio, Zamora-Ros, Raul, Cayssials, Valerie, Clèries, Ramon, Torrents, Maria, Byrnes, Graham, Weiderpass, Elisabete, Sandström, Maria, Almquist, Martin, Boutron-Ruault, Marie-Christine, Tjønneland, Anne, Kyrø, Cecilie, Katzke, Verena A., Le Cornet, Charlotte, Masala, Giovanna, Krogh, Vittorio, Iannuzzo, Gabriella, Tumino, Rosario, Milani, Lorenzo, Skeie, Guri, Ubago-Guisado, Esther, Amiano, Pilar, Chirlaque, María-Dolores, Ardanaz, Eva, Janzi, Suzanne, Eriksson, Linda, Freisling, Heinz, Heath, Alicia K., Rinaldi, Sabina, and Agudo, Antonio
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Background: Dietary pattern analysis has gained particular interest, because it reflects the complexity of dietary intake. The aim of this study was to explore the associations between a posteriori dietary patterns, derived using a data-driven approach, and the risk of differentiated thyroid cancer (TC) in Europe. Methods: This investigation included 450,064 adults from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Dietary intake was assessed using validated country-specific dietary questionnaires. A posteriori dietary patterns were computed using principal component analyses. Cox regression was used to calculate multivariable adjusted hazard ratios (HRs) and 95% confidence intervals (CIs). Results: After a mean follow-up time of 14 years, 712 first differentiated TCs were diagnosed. In the fully adjusted model, a dietary pattern characterized by alcohol consumption (basically beer and wine) was negatively associated with differentiated TC risk (HRQ4vs.Q1 = 0.75; 95% CI:0.60–0.94, P-trend = 0.005), while a dietary pattern rich in sweetened beverages was positively associated with differentiated TC risk (HRQ4vs.Q1 = 1.26; 95% CI:0.99–1.61; P-trend = 0.07). The remaining 8 dietary patterns were not related to differentiated TC risk. The intake of sweetened beverages was positively associated with differentiated TC risk (HR100mL/d = 1.05; 95% CI:1.00–1.11), especially with papillary TC risk (HR100mL/d = 1.07; 95% CI:1.01–1.13). Similar results were observed with sugary and artificially sweetened beverages. Conclusions: The investigation of dietary patterns detected that the consumption of sweetened beverages was associated with a higher risk of differentiated thyroid cancer. Our results are in line with the general dietary recommendations of reducing the consumption of sweetened beverages.
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- 2022
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247. Inflammatory potential of the diet and association with risk of differentiated thyroid cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
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Lécuyer, Lucie, Laouali, Nasser, Dossus, Laure, Shivappa, Nitin, Hébert, James R., Agudo, Antonio, Tjonneland, Anne, Halkjaer, Jytte, Overvad, Kim, Katzke, Verena A., Le Cornet, Charlotte, Schulze, Matthias B., Jannasch, Franziska, Palli, Domenico, Agnoli, Claudia, Tumino, Rosario, Dragna, Luca, Iannuzzo, Gabriella, Jensen, Torill Enget, Brustad, Magritt, Skeie, Guri, Zamora-Ros, Raul, Rodriguez-Barranco, Miguel, Amiano, Pilar, Chirlaque, María-Dolores, Ardanaz, Eva, Almquist, Martin, Sonestedt, Emily, Sandström, Maria, Nilsson, Lena Maria, Weiderpass, Elisabete, Huybrechts, Inge, Rinaldi, Sabina, Boutron-Ruault, Marie-Christine, Truong, Thérèse, Lécuyer, Lucie, Laouali, Nasser, Dossus, Laure, Shivappa, Nitin, Hébert, James R., Agudo, Antonio, Tjonneland, Anne, Halkjaer, Jytte, Overvad, Kim, Katzke, Verena A., Le Cornet, Charlotte, Schulze, Matthias B., Jannasch, Franziska, Palli, Domenico, Agnoli, Claudia, Tumino, Rosario, Dragna, Luca, Iannuzzo, Gabriella, Jensen, Torill Enget, Brustad, Magritt, Skeie, Guri, Zamora-Ros, Raul, Rodriguez-Barranco, Miguel, Amiano, Pilar, Chirlaque, María-Dolores, Ardanaz, Eva, Almquist, Martin, Sonestedt, Emily, Sandström, Maria, Nilsson, Lena Maria, Weiderpass, Elisabete, Huybrechts, Inge, Rinaldi, Sabina, Boutron-Ruault, Marie-Christine, and Truong, Thérèse
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Purpose: Chronic inflammation is thought to initiate or promote differentiated thyroid cancer (DTC) and previous studies have shown that diet can modulate this inflammatory process. We aimed to evaluate the association of several dietary scores reflecting the inflammatory potential of the diet with DTC risk. Methods: Within the EPIC cohort, 450,063 participants were followed during a mean period of 14 years, and 712 newly incident DTC cases were identified. Associations between four dietary inflammatory scores [the dietary inflammatory index (DII®) and two energy-adjusted derivatives (the E-DIIr and the E-DIId), and the Inflammatory Score of the Diet (ISD)] and DTC risk were evaluated in the EPIC cohort using multivariable Cox regression models. Results: Positive associations were observed between DTC risk and the DIIs (HR for 1 SD increase in DII: 1.11, 95%CI: 1.01, 1.23, similar results for its derivatives), but not with the ISD (HR for 1 SD increase: 1.04, 95% CI 0.93, 1.16). Conclusion: Diet-associated inflammation, as estimated by the DII and its derivatives, was weakly positively associated with DTC risk in a European adult population. These results suggesting that diet-associated inflammation acts in the etiology of DTC need to be validated in independent studies.
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- 2022
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248. Metabolic signatures of healthy lifestyle patterns and colorectal cancer risk in a European cohort
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Rothwell, Joseph A., Murphy, Neil, Bešević, Jelena, Kliemann, Nathalie, Jenab, Mazda, Ferrari, Pietro, Achaintre, David, Gicquiau, Audrey, Vozar, Béatrice, Scalbert, Augustin, Huybrechts, Inge, Freisling, Heinz, Prehn, Cornelia, Adamski, Jerzy, Cross, Amanda J., Pala, Valeria Maria, Boutron-Ruault, Marie-Christine, Dahm, Christina C., Overvad, Kim, Gram, Inger Torhild, Sandanger, Torkjel M., Skeie, Guri, Jakszyn, Paula, Tsilidis, Kostas K., Aleksandrova, Krasimira, Schulze, Matthias B., Hughes, David J., van Guelpen, Bethany, Bodén, Stina, Sánchez, Maria-José, Schmidt, Julie A., Katzke, Verena, Kühn, Tilman, Colorado-Yohar, Sandra, Tumino, Rosario, Bueno-de-Mesquita, Bas, Vineis, Paolo, Masala, Giovanna, Panico, Salvatore, Eriksen, Anne Kirstine, Tjønneland, Anne, Aune, Dagfinn, Weiderpass, Elisabete, Severi, Gianluca, Chajès, Véronique, Gunter, Marc J., Rothwell, Joseph A., Murphy, Neil, Bešević, Jelena, Kliemann, Nathalie, Jenab, Mazda, Ferrari, Pietro, Achaintre, David, Gicquiau, Audrey, Vozar, Béatrice, Scalbert, Augustin, Huybrechts, Inge, Freisling, Heinz, Prehn, Cornelia, Adamski, Jerzy, Cross, Amanda J., Pala, Valeria Maria, Boutron-Ruault, Marie-Christine, Dahm, Christina C., Overvad, Kim, Gram, Inger Torhild, Sandanger, Torkjel M., Skeie, Guri, Jakszyn, Paula, Tsilidis, Kostas K., Aleksandrova, Krasimira, Schulze, Matthias B., Hughes, David J., van Guelpen, Bethany, Bodén, Stina, Sánchez, Maria-José, Schmidt, Julie A., Katzke, Verena, Kühn, Tilman, Colorado-Yohar, Sandra, Tumino, Rosario, Bueno-de-Mesquita, Bas, Vineis, Paolo, Masala, Giovanna, Panico, Salvatore, Eriksen, Anne Kirstine, Tjønneland, Anne, Aune, Dagfinn, Weiderpass, Elisabete, Severi, Gianluca, Chajès, Véronique, and Gunter, Marc J.
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Background & Aims: Colorectal cancer risk can be lowered by adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) guidelines. We derived metabolic signatures of adherence to these guidelines and tested their associations with colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort. Methods: Scores reflecting adherence to the WCRF/AICR recommendations (scale, 1–5) were calculated from participant data on weight maintenance, physical activity, diet, and alcohol among a discovery set of 5738 cancer-free European Prospective Investigation into Cancer and Nutrition participants with metabolomics data. Partial least-squares regression was used to derive fatty acid and endogenous metabolite signatures of the WCRF/AICR score in this group. In an independent set of 1608 colorectal cancer cases and matched controls, odds ratios (ORs) and 95% CIs were calculated for colorectal cancer risk per unit increase in WCRF/AICR score and per the corresponding change in metabolic signatures using multivariable conditional logistic regression. Results: Higher WCRF/AICR scores were characterized by metabolic signatures of increased odd-chain fatty acids, serine, glycine, and specific phosphatidylcholines. Signatures were inversely associated more strongly with colorectal cancer risk (fatty acids: OR, 0.51 per unit increase; 95% CI, 0.29–0.90; endogenous metabolites: OR, 0.62 per unit change; 95% CI, 0.50–0.78) than the WCRF/AICR score (OR, 0.93 per unit change; 95% CI, 0.86–1.00) overall. Signature associations were stronger in male compared with female participants. Conclusions: Metabolite profiles reflecting adherence to WCRF/AICR guidelines and additional lifestyle or biological risk factors were associated with colorectal cancer. Measuring a specific panel of metabolites representative of a healthy or unhealthy lifestyle may identify strata of the population at higher risk of colorectal cancer.
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- 2022
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249. Inflammatory potential of diet and pancreatic cancer risk in the EPIC study
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Cayssials, Valerie, Buckland, Genevieve, Crous-Bou, Marta, Bonet, Catalina, Weiderpass, Elisabete, Skie, Guri, Aune, Dagfinn, Heath, Alicia, Nøst, Therese Haugdahl, Masala, Giovanna, Agnoli, Claudia, De Magistris, Maria Santucci, Bueno-de-Mesquita, Bas, Derksen, Jeroen, Huybrechts, Inge, Ferrari, Pietro, Franklin, Oskar, Bodén, Stina, Schulze, Matthias, Huerta, Jose Maria, Barricarte, Aurelio, Sacerdote, Carlotta, Amiano, Pilar, Tumino, Rosario, Molina-Montes, Esther, Tjønneland, Anne, Kyrø, Cecilie, Severi, Gianluca, Boutron-Ruault, Marie-Christine, Rebours, Vinciane, Katzke, Verena, Agudo, Antonio, Jakszyn, Paula, Cayssials, Valerie, Buckland, Genevieve, Crous-Bou, Marta, Bonet, Catalina, Weiderpass, Elisabete, Skie, Guri, Aune, Dagfinn, Heath, Alicia, Nøst, Therese Haugdahl, Masala, Giovanna, Agnoli, Claudia, De Magistris, Maria Santucci, Bueno-de-Mesquita, Bas, Derksen, Jeroen, Huybrechts, Inge, Ferrari, Pietro, Franklin, Oskar, Bodén, Stina, Schulze, Matthias, Huerta, Jose Maria, Barricarte, Aurelio, Sacerdote, Carlotta, Amiano, Pilar, Tumino, Rosario, Molina-Montes, Esther, Tjønneland, Anne, Kyrø, Cecilie, Severi, Gianluca, Boutron-Ruault, Marie-Christine, Rebours, Vinciane, Katzke, Verena, Agudo, Antonio, and Jakszyn, Paula
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Purpose: There is existing evidence on the potential role of chronic inflammation in the pathogenesis of pancreatic cancer (PC) and on how risk may be modulated by dietary factors. Pro-inflammatory diets are suggested to be associated with increased risk of PC but, so far, evidence remains not conclusive. We examined the association between the dietary inflammatory potential and PC risk within the European Prospective Investigation into Cancer and Nutrition (EPIC) study, which includes 450,112 participants. Methods: After a 14-year follow-up, a total of 1239 incident PC cases were included in this study. The inflammatory potential of the diet was estimated using an Inflammatory Score of the Diet (ISD). Hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between the ISD and PC were estimated using multivariable Cox regression models, adjusted for known risk factors for PC. Results: Participants with higher ISDs had a higher risk of developing PCs. In the fully adjusted multivariate model, the risk of PC increased by 11% (HR 1.11, 95% CI 1.02–1.22) for 1 point each standard deviation increase in the ISD score. Neither obesity nor any other known risk factor for PC showed statistically significant interactions. Conclusion: To the best of our knowledge, this is the first prospective study reporting a positive relationship between the inflammatory potential of diet and PC. Since early diagnosis and treatment of pancreatic cancer might be challenging, prevention remains the major hope for reducing the burden of this disease.
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- 2022
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250. Prediagnostic alterations in circulating bile acid profiles in the development of hepatocellular carcinoma
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Stepien, Magdalena, Lopez-Nogueroles, Marina, Lahoz, Agustin, Kühn, Tilman, Perlemuter, Gabriel, Voican, Cosmin, Ciocan, Dragos, Boutron-Ruault, Marie-Christine, Jansen, Eugene, Viallon, Vivian, Leitzmann, Michael, Tjønneland, Anne, Severi, Gianluca, Mancini, Francesca Romana, Dong, Catherine, Kaaks, Rudolf, Fortner, Renee Turzanski, Bergmann, Manuela M., Boeing, Heiner, Trichopoulou, Antonia, Karakatsani, Anna, Peppa, Eleni, Palli, Domenico, Krogh, Vittorio, Tumino, Rosario, Sacerdote, Carlotta, Panico, Salvatore, Bueno-de-Mesquita, H. Bas, Skeie, Guri, Merino, Susana, Ros, Raul Zamora, Sánchez, Maria Jose, Amiano, Pilar, Huerta, Jose Mª, Barricarte, Aurelio, Sjöberg, Klas, Ohlsson, Bodil, Nyström, Hanna, Werner, Mårten, Perez-Cornago, Aurora, Schmidt, Julie A., Freisling, Heinz, Scalbert, Augustin, Weiderpass, Elisabete, Christakoudi, Sofia, Gunter, Marc J., Jenab, Mazda, Stepien, Magdalena, Lopez-Nogueroles, Marina, Lahoz, Agustin, Kühn, Tilman, Perlemuter, Gabriel, Voican, Cosmin, Ciocan, Dragos, Boutron-Ruault, Marie-Christine, Jansen, Eugene, Viallon, Vivian, Leitzmann, Michael, Tjønneland, Anne, Severi, Gianluca, Mancini, Francesca Romana, Dong, Catherine, Kaaks, Rudolf, Fortner, Renee Turzanski, Bergmann, Manuela M., Boeing, Heiner, Trichopoulou, Antonia, Karakatsani, Anna, Peppa, Eleni, Palli, Domenico, Krogh, Vittorio, Tumino, Rosario, Sacerdote, Carlotta, Panico, Salvatore, Bueno-de-Mesquita, H. Bas, Skeie, Guri, Merino, Susana, Ros, Raul Zamora, Sánchez, Maria Jose, Amiano, Pilar, Huerta, Jose Mª, Barricarte, Aurelio, Sjöberg, Klas, Ohlsson, Bodil, Nyström, Hanna, Werner, Mårten, Perez-Cornago, Aurora, Schmidt, Julie A., Freisling, Heinz, Scalbert, Augustin, Weiderpass, Elisabete, Christakoudi, Sofia, Gunter, Marc J., and Jenab, Mazda
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Bile acids (BAs) play different roles in cancer development. Some are carcinogenic and BA signaling is also involved in various metabolic, inflammatory and immune-related processes. The liver is the primary site of BA synthesis. Liver dysfunction and microbiome compositional changes, such as during hepatocellular carcinoma (HCC) development, may modulate BA metabolism increasing concentration of carcinogenic BAs. Observations from prospective cohorts are sparse. We conducted a study (233 HCC case-control pairs) nested within a large observational prospective cohort with blood samples taken at recruitment when healthy with follow-up over time for later cancer development. A targeted metabolomics method was used to quantify 17 BAs (primary/secondary/tertiary; conjugated/unconjugated) in prediagnostic plasma. Odd ratios (OR) for HCC risk associations were calculated by multivariable conditional logistic regression models. Positive HCC risk associations were observed for the molar sum of all BAs (ORdoubling = 2.30, 95% confidence intervals [CI]: 1.76-3.00), and choline- and taurine-conjugated BAs. Relative concentrations of BAs showed positive HCC risk associations for glycoholic acid and most taurine-conjugated BAs. We observe an association between increased HCC risk and higher levels of major circulating BAs, from several years prior to tumor diagnosis and after multivariable adjustment for confounders and liver functionality. Increase in BA concentration is accompanied by a shift in BA profile toward higher proportions of taurine-conjugated BAs, indicating early alterations of BA metabolism with HCC development. Future studies are needed to assess BA profiles for improved stratification of patients at high HCC risk and to determine whether supplementation with certain BAs may ameliorate liver dysfunction.
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- 2022
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