Search

Your search keyword '"Bolt, Hermann M."' showing total 966 results
Start Over Author "Bolt, Hermann M."
966 results on '"Bolt, Hermann M."'

201. Genotyping NAT2 with only two SNPs (rs1041983 and rs1801280) outperforms the tagging SNP rs1495741 and is equivalent to the conventional 7-SNP NAT2 genotype

Author

Selinski, Silvia, primary, Blaszkewicz, Meinolf, additional, Lehmann, Marie-Louise, additional, Ovsiannikov, Daniel, additional, Moormann, Oliver, additional, Guballa, Christoph, additional, Kress, Alexander, additional, Tru, Michael C., additional, Gerullis, Holger, additional, Otto, Thomas, additional, Barski, Dimitri, additional, Niegisch, Günter, additional, Albers, Peter, additional, Frees, Sebastian, additional, Brenner, Walburgis, additional, Thüroff, Joachim W., additional, Angeli-Greaves, Miriam, additional, Seidel, Thilo, additional, Roth, Gerhard, additional, Dietrich, Holger, additional, Ebbinghaus, Rainer, additional, Prager, Hans M., additional, Bolt, Hermann M., additional, Falkenstein, Michael, additional, Zimmermann, Anna, additional, Klein, Torsten, additional, Reckwitz, Thomas, additional, Roemer, Hermann C., additional, Löhlein, Dietrich, additional, Weistenhöfer, Wobbeke, additional, Schöps, Wolfgang, additional, Hassan Rizvi, Syed Adibul, additional, Aslam, Muhammad, additional, Bánfi, Gergely, additional, Romics, Imre, additional, Steffens, Michael, additional, Ekici, Arif B., additional, Winterpacht, Andreas, additional, Ickstadt, Katja, additional, Schwender, Holger, additional, Hengstler, Jan G., additional, and Golka, Klaus, additional

Published
2011
Full Text
View/download PDF

202. Urinary bladder cancer risk in relation to a single nucleotide polymorphism (rs2854744) in the insulin-like growth factor-binding protein-3 (IGFBP3) gene

Author

Selinski, Silvia, primary, Lehmann, Marie-Louise, additional, Blaszkewicz, Meinolf, additional, Ovsiannikov, Daniel, additional, Moormann, Oliver, additional, Guballa, Christoph, additional, Kress, Alexander, additional, Truß, Michael C., additional, Gerullis, Holger, additional, Otto, Thomas, additional, Barski, Dimitri, additional, Niegisch, Günter, additional, Albers, Peter, additional, Frees, Sebastian, additional, Brenner, Walburgis, additional, Thüroff, Joachim W., additional, Angeli-Greaves, Miriam, additional, Seidel, Thilo, additional, Roth, Gerhard, additional, Volkert, Frank, additional, Ebbinghaus, Rainer, additional, Prager, Hans-Martin, additional, Lukas, Cordula, additional, Bolt, Hermann M., additional, Falkenstein, Michael, additional, Zimmermann, Anna, additional, Klein, Torsten, additional, Reckwitz, Thomas, additional, Roemer, Hermann C., additional, Hartel, Mark, additional, Weistenhöfer, Wobbeke, additional, Schöps, Wolfgang, additional, Rizvi, S. Adibul Hassan, additional, Aslam, Muhammad, additional, Bánfi, Gergely, additional, Romics, Imre, additional, Ickstadt, Katja, additional, Hengstler, Jan G., additional, and Golka, Klaus, additional

Published
2011
Full Text
View/download PDF

203. Assessment of DNA integrity (COMET assay) in sperm cells of boron-exposed workers

Author

Duydu, Yalçın, primary, Başaran, Nurşen, additional, Üstündağ, Aylin, additional, Aydın, Sevtap, additional, Ündeğer, Ülkü, additional, Ataman, Osman Yavuz, additional, Aydos, Kaan, additional, Düker, Yalçın, additional, Ickstadt, Katja, additional, Waltrup, Britta Schulze, additional, Golka, Klaus, additional, and Bolt, Hermann M., additional

Published
2011
Full Text
View/download PDF

204. Reproductive toxicity parameters and biological monitoring in occupationally and environmentally boron-exposed persons in Bandırma, Turkey

Author

Duydu, Yalçın, primary, Başaran, Nurşen, additional, Üstündağ, Aylin, additional, Aydın, Sevtap, additional, Ündeğer, Ülkü, additional, Ataman, Osman Yavuz, additional, Aydos, Kaan, additional, Düker, Yalçın, additional, Ickstadt, Katja, additional, Waltrup, Britta Schulze, additional, Golka, Klaus, additional, and Bolt, Hermann M., additional

Published
2011
Full Text
View/download PDF

206. Contributors

Author

Başaran, Nurşen, Beker, Ulker, Bicak, Niyazi, Bick, Amos, Blahušiak, Marek, Bolt, Hermann M., Bryjak, Marek, Darwish, Nawaf Bin, Duydu, Yalçın, Dydo, Piotr, Foutch, Gary L., Freger, Viatcheslav (Slava), Hilal, Nidal, Kabay, Nalan, Kim, Jae-Hong, Kochkodan, Victor, Kot, Fyodor S., Koźlecki, Tomasz, Lahav, Ori, Lou, Jidong, Nir, Oded, Nishihama, Syouhei, Oron, Gideon, Ozbelge, H. Onder, Park, Pyung-Kyu, Polowczyk, Izabela, Sagiv, Abraham (Avi), Schlosser, Štefan, Semiat, Raphael (Rafi), Senkal, Bahire Filiz, Shemer, Hilla, Simsek, Esra Bilgin, Turek, Marian, Yilmaz, Levent, Yoshizuka, Kazuharu, and Zerze, Hasan

Published
2015
Full Text
View/download PDF

207. Rs710521[A] on chromosome 3q28 close to TP63 is associated with increased urinary bladder cancer risk

Author

Lehmann, Marie-Louise, primary, Selinski, Silvia, additional, Blaszkewicz, Meinolf, additional, Orlich, Michael, additional, Ovsiannikov, Daniel, additional, Moormann, Oliver, additional, Guballa, Christoph, additional, Kress, Alexander, additional, Truss, Michael C., additional, Gerullis, Holger, additional, Otto, Thomas, additional, Barski, Dimitri, additional, Niegisch, Günter, additional, Albers, Peter, additional, Frees, Sebastian, additional, Brenner, Walburgis, additional, Thüroff, Joachim W., additional, Angeli-Greaves, Miriam, additional, Seidel, Thilo, additional, Roth, Gerhard, additional, Dietrich, Holger, additional, Ebbinghaus, Rainer, additional, Prager, Hans M., additional, Bolt, Hermann M., additional, Falkenstein, Michael, additional, Zimmermann, Anna, additional, Klein, Torsten, additional, Reckwitz, Thomas, additional, Roemer, Hermann C., additional, Löhlein, Dietrich, additional, Weistenhöfer, Wobbeke, additional, Schöps, Wolfgang, additional, Beg, Anwer E., additional, Aslam, Muhammad, additional, Bánfi, Gergely, additional, Romics, Imre, additional, Ickstadt, Katja, additional, Schwender, Holger, additional, Winterpacht, Andreas, additional, Hengstler, Jan G., additional, and Golka, Klaus, additional

Published
2010
Full Text
View/download PDF

208. Genetic susceptibility to environmental toxicants : the interface between human and experimental studies in the development of new toxicological concepts

Author

Thier, Ricarda, Golka, Klaus, Bruning, Thomas, Ko, Yon, Bolt, Hermann M., Thier, Ricarda, Golka, Klaus, Bruning, Thomas, Ko, Yon, and Bolt, Hermann M.

Abstract

The growing knowledge of the genetic polymorphisms of enzymes metabolising xenobiotics in humans and their connections with individual susceptibility towards toxicants has created new and important interfaces between human epidemiology and experimental toxicology. The results of molecular epidemiological studies may provide new hypotheses and concepts, which call for experimental verification, and experimental concepts may obtain further proof by molecular epidemiological studies. If applied diligently, these possibilities may be combined to lead to new strategies of human-oriented toxicological research. This overview will present some outstanding examples for such strategies taken from the practically very important field of occupational toxicology. The main focus is placed on the effects of enzyme polymorphisms of the xenobiotic metabolism in association with the induction of bladder cancer and renal cell cancer after exposure to occupational chemicals. Also, smoking and induction of head and neck squamous cell cancer are considered.

Published
2002

213. European aspects of standard setting in occupational hygiene and medicine

Author

Thier, Ricarda, Bolt, Hermann M., Thier, Ricarda, and Bolt, Hermann M.

Abstract

Occupational standards concerning the allowable concentrations of chemical compounds in the ambient air of workplaces have been established in several countries at national levels. With the integration of the European Union, a need exists for establishing harmonized Occupational Exposure Limits. For analytical developments, it is apparent that methods for speciation or fractionation of carcinogenic metal compounds will be of increasing practical importance for standard setting. Criteria of applicability under field conditions, cost-effectiveness, and robustness are practical driving forces for new developments. When the European Union issued a list of 62 chemical substances with Occupational Exposure Limits in 2000, 25 substances received a 'skin' notation. The latter indicates that toxicologically significant amounts may be taken up via the skin. Similar notations exist on national levels. For such substances, monitoring concentrations in ambient air will not be sufficient; biological monitoring strategies will gain further importance in the medical surveillance of workers who are exposed to such compounds. Proceedings in establishing legal frameworks for a biological monitoring of chemical exposures within Europe are paralleled by scientific advances in this field. A new aspect is the possibility of a differential adduct monitoring, using blood proteins of different half-life or lifespan. This technique allows differentiation between long-term mean exposure to reactive chemicals and short-term episodes, for example, by accidental overexposure. For further analytical developments, the following issues have been addressed as being particularly important: New dose monitoring strategies, sensitive and reliable methods for detection of DNA adducts, cytogenetic parameters in biological monitoring, methods to monitor exposure to sensitizing chemicals, and parameters for individual susceptibilities to chemical toxicants.

Published
2001

223. Head and Neck Squamous-Cell Cancer and its Association with Polymorphic Enzymes of Xenobiotic Metabolism and Repair

Author

Harth, Volker, primary, Schäfer, Martin, additional, Abel, Josef, additional, Maintz, Laura, additional, Neuhaus, Thomas, additional, Besuden, Mette, additional, Primke, Robert, additional, Wilkesmann, Anja, additional, Thier, Ricarda, additional, Vetter, Hans, additional, Ko, Yon-Dschun, additional, Brüning, Thomas, additional, Bolt, Hermann M., additional, and Ickstadt, Katja, additional

Published
2008
Full Text
View/download PDF

233. Carcinogenicity and genotoxicity of ethylene oxide : new aspects and recent advances

Author

Thier, Ricarda, Bolt, Hermann M., Thier, Ricarda, and Bolt, Hermann M.

Abstract

Long-term inhalation studies in rodents have presented unequivocal evidence of experimental carcinogenicity of ethylene oxide, based on the formation of malignant tumors at multiple sites. However, despite a considerable body of epidemiological data only limited evidence has been obtained of its carcinogenicity in humans. Ethylene oxide is not only an important exogenous toxicant, but it is also formed from ethylene as a biological precursor. Ethylene is a normal body constituent; its endogenous formation is evidenced by exhalation in rats and in humans. Consequently, ethylene oxide must also be regarded as a physiological compound. The most abundant DNA adduct of ethylene oxide is 7-(2-hydroxyethyl)guanine (HOEtG). Open questions are the nature and role of tissue-specific factors in ethylene oxide carcinogenesis and the physiological and quantitative role of DNA repair mechanisms. The detection of remarkable individual differences in the susceptibility of humans has promoted research into genetic factors that influence the metabolism of ethylene oxide. With this background it appears that current PBPK models for trans-species extrapolation of ethylene oxide toxicity need to be refined further. For a cancer risk assessment at low levels of DNA damage, exposure-related adducts must be discussed in relation to background DNA damage as well as to inter- and intraindividual variability. In rats, subacute ethylene oxide exposures on the order of 1 ppm (1.83 mg/m3) cause DNA adduct levels (HOEtG) of the same magnitude as produced by endogenous ethylene oxide. Based on very recent studies the endogenous background levels of HOEtG in DNA of humans are comparable to those that are produced in rodents by repetitive exogenous ethylene oxide exposures of about 10 ppm (18.3 mg/m3). Experimentally, ethylene oxide has revealed only weak mutagenic effects in vivo, which are confined to higher doses. It has been concluded that long-term human occupational exposure to low airborne co

Published
2000

238. Breast cancer: a candidate gene approach across the estrogen metabolic pathway

Author

Justenhoven, Christina, primary, Hamann, Ute, additional, Schubert, Falk, additional, Zapatka, Marc, additional, Pierl, Christiane B., additional, Rabstein, Sylvia, additional, Selinski, Silvia, additional, Mueller, Tina, additional, Ickstadt, Katja, additional, Gilbert, Michael, additional, Ko, Yon-Dschun, additional, Baisch, Christian, additional, Pesch, Beate, additional, Harth, Volker, additional, Bolt, Hermann M., additional, Vollmert, Caren, additional, Illig, Thomas, additional, Eils, Roland, additional, Dippon, Jürgen, additional, and Brauch, Hiltrud, additional

Published
2007
Full Text
View/download PDF

243. Acetaldehyde

Author

Eckert, Marc, primary, Fleischmann, Gerald, additional, Jira, Reinhard, additional, Bolt, Hermann M., additional, and Golka, Klaus, additional

Published
2006
Full Text
View/download PDF

245. Toxicological comments to the discussion about REACH

Author

Greim, Helmut, primary, Arand, Michael, additional, Autrup, Herman, additional, Bolt, Hermann M., additional, Bridges, James, additional, Dybing, Erik, additional, Glomot, Rémi, additional, Foa, Vito, additional, and Schulte-Hermann, Rolf, additional

Published
2006
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results