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Browse through any reputable bookstore in Britain and somewhere between Hare Krishna and hunting you'll likely find Hooligan Lit. A peculiarly British literary genre, Hooligan Lit burst onto the U.K. [...]

To paraphrase Bertolt Brecht, art can be a mirror to reflect reality or a hammer with which to shape it. The same could be said of sport. For a brief [...]

The Olympic movement aspires to some pretty lofty goals (at least according to their website), which include 'building a peaceful and better world through mutual understanding, solidarity, friendship and fair [...]

The Cold War And the New Imperialism: A Global History, 1945-2005 by Henry Heller Monthly Review Press, 2006 That long-distance runner of the American Left, Harry Magdoff, once wrote, 'As [...]

Dave Zirin combines progressive politics with sports journalism, exposing the 'athletics-industrial complex' that rules professional sports. He is a columnist for SLAM magazine, a regular contributor to The Nation and [...]

Renaissance thinker Michel de Montaigne once remarked, 'Mistrust a man who takes games too seriously; it means he doesn't take life seriously enough.' Thankfully those brave protestors who disrupted a [...]

Unless you live somewhere in the Arctic Circle or the jungles of the Amazon, you'll have heard the news about David Beckham. The postmodern prince of the sports world, with [...]

I admit to cheering (almost crying) when Tommy Douglas was announced as our Greatest Canadian on the popular CBC show. Hey, it's gloomy times for the Left, and we take [...]

In the age of sports superstars with multi-million-dollar salaries, we tend not to think of professional athletes as workers. But, like other workers, professional athletes sell their labour to capitalists [...]

Do you also get utility bills with pages of inconsequential, incomprehensible data, with a figure at the bottom that just seems too high? No matter how hard the companies try, [...]

The article by Mark Greener (1) and commentary by the Editor (2) give us a superb view of the present and future of enzymology, but there are a]so lessons to [...]

Professor Graham Cook's suggestion (1) that serine in the primordial soup played a role in determining the left-handedness of amino acids in organisms is complemented by the possibility that this [...]

Theoretical approaches to crystallisation process development were tested on a pharmaceutical development compound and resulted in a well-behaved crystallisation. The crystallisation type was selected from thermal data. Yield and productivity were fixed from the solubility curve. Solution eutectic data were used to set the specification of enantiomeric purity for the input material. Agitation and cooling parameters were established using scale-down laboratory trials. Heat transfer was the rate-limiting step for crystal growth. In-line technology was beneficial in the laboratory but not necessary on scale-up.

To identify the role of physiologic magnesium concentrations on the induction of placental apoptosis in vitro and test the antiapoptotic action of antioxidants.

Precompetitive collaborations on new enabling technologies for research and development are becoming popular among pharmaceutical companies. The Enabling Technologies Consortium (ETC), a precompetitive collaboration of leading innovative pharmaceutical companies, identifies and executes projects, often with third-party collaborators, to develop new tools and technologies of mutual interest. Here, we report the results of one of the first ETC projects: the development of a user-friendly population balance model (PBM)-based crystallization simulator software. This project required the development of PBM software with integrated experimental data handling, kinetic parameter regression, interactive process simulation, visualization, and optimization capabilities incorporated in a computationally efficient and robust software platform. Inputs from a team of experienced scientists at 10 ETC member companies helped define a set of software features that guided a team of crystallization modelers to develop software incorporating these features. Communication, continuous testing, and feedback between the ETC and the academic team facilitated the software development. The product of this project, a software tool called CrySiV, an acronym for Crystallization Simulation and Visualization, is reported herein. Currently, CrySiV can be used for cooling, antisolvent, and combined cooling and antisolvent crystallization processes, with primary and secondary nucleation, growth, dissolution, agglomeration, and breakage of crystals. This paper describes the features and the numerical methods of the software and presents two case studies demonstrating its use for parameter estimation. In the first case study, a simulated data set is used to demonstrate the capabilities of the software to find kinetic parameters and its goodness of fit to a known solution. In the second case study, the kinetics of an antisolvent crystallization of indomethacin from a ternary solvent system are estimated, providing a practical example of the tool.