Search

A growing number of studies of auditory processing are being carried out in awake, behaving animals, creating a need for precisely controlled sound delivery without restricting head movements. We have designed a system for closed-field stimulus presentation in freely moving ferrets, which comprises lightweight, adjustable headphones that can be consistently positioned over the ears via a small, skull-mounted implant. The invasiveness of the implant was minimized by simplifying its construction and using dental adhesive only for attaching it to the skull, thereby reducing the surgery required and avoiding the use of screws or other anchoring devices. Attaching the headphones to a chronic implant also reduced the amount of contact they had with the head and ears, increasing the willingness of the animals to wear them. We validated sound stimulation via the headphones in ferrets trained previously in a free-field task to localize stimuli presented from one of two loudspeakers. Noise bursts were delivered binaurally over the headphones and interaural level differences (ILDs) were introduced to allow the sound to be lateralized. Animals rapidly transferred from the free-field task to indicate the perceived location of the stimulus presented over headphones. They showed near perfect lateralization with a 5dB ILD, matching the scores achieved in the free-field task. As expected, the ferrets’ performance declined when the ILD was reduced in value. This closed-field system can easily be adapted for use in other species, and provides a reliable means of presenting closed-field stimuli whilst monitoring behavioral responses in freely moving animals. [Copyright &y& Elsevier]

Humans perceive a harmonic series as a single auditory object with a pitch equivalent to the fundamental frequency (F0) of the series. When harmonics are presented to alternate ears, the repetition rate of the waveform at each ear doubles. If the harmonics are resolved, then the pitch perceived is still equivalent to F0, suggesting the stimulus is binaurally integrated before pitch is processed. However, unresolved harmonics give rise to the doubling of pitch which would be expected from monaural processing (Bernstein and Oxenham, J. Acoust. Soc. Am., 113:3323–3334, ). We used similar stimuli to record responses of multi-unit clusters in the central nucleus of the inferior colliculus (IC) of anesthetized guinea pigs (urethane supplemented by fentanyl/fluanisone) to determine the nature of the representation of harmonic stimuli and to what extent there was binaural integration. We examined both the temporal and rate-tuning of IC clusters and found no evidence for binaural integration. Stimuli comprised all harmonics below 10 kHz with fundamental frequencies (F0) from 50 to 400 Hz in half-octave steps. In diotic conditions, all the harmonics were presented to both ears. In dichotic conditions, odd harmonics were presented to one ear and even harmonics to the other. Neural characteristic frequencies (CF, n = 85) were from 0.2 to 14.7 kHz; 29 had CFs below 1 kHz. The majority of clusters responded predominantly to the contralateral ear, with the dominance of the contralateral ear increasing with CF. With diotic stimuli, over half of the clusters (58%) had peaked firing rate vs. F0 functions. The most common peak F0 was 141 Hz. Almost all (98%) clusters phase locked diotically to an F0 of 50 Hz, and approximately 40% of clusters still phase locked significantly (Rayleigh coefficient >13.8) at the highest F0 tested (400 Hz). These results are consistent with the previous reports of responses to amplitude-modulated stimuli. Clusters phase locked significantly at a frequency equal to F0 for contralateral and diotic stimuli but at 2F0 for dichotic stimuli. We interpret these data as responses following the envelope periodicity in monaural channels rather than as a binaurally integrated representation. [ABSTRACT FROM AUTHOR]

Abstract: Bilateral cochlear implants (CI) offer a unique opportunity for the study of spatial hearing plasticity in humans. Here we studied the recovery of spatial hearing in two sequential bilateral CI recipients, adopting a longitudinal approach. Each recipient was tested in a sound-source identification task shortly after bilateral activation and at 1, 6, and 12 months follow-up. The results show fast recovery (1 month from CI activation) in the recipient who had substantial experience with auditory cues in adulthood. By contrast, the bilateral CI recipient who developed profound deafness in childhood, regained spatial hearing abilities only 12 months after CI activation. These findings provide the first direct evidence that recovery of auditory spatial abilities in bilateral CI recipients can occur shortly after activation of the two devices. In addition, they suggest that previous auditory experience can constrain the time course of this recovery. [Copyright &y& Elsevier]

This paper addresses the problem of direction-of-arrival (DOA) estimation both in azimuthal and elevation angle from binaural sound that is processed with a head-related transfer function (HRTF). Previously, we proposed a weighted Wiener gain (WWG) method for two-dimensional DOA estimation with two-directional microphones. However, for signals processed with HRTFs, peaks in the spatial spectra of WWG indicating true sources can mingle with spurious peaks. To resolve this situation, we propose to apply incremental source attenuation (ISA) in combination with WWG. In fact, ISA reduces spectral components originating from specified sound sources and thereby improves the localization accuracy of the next targeted source in the proposed incremental estimation procedure. We conduct computer simulations using directional microphones and four HRTF sets corresponding to four individuals. The proposed method is compared to two DOA estimation methods that are equivalent to two generalized cross-correlation functions and two high-resolution methods of multiple signal classification (MUSIC) and minimum variance method. For comparison purposes, we introduce binary coherence detection (BCD) to high-resolution methods for emphasizing valid spectral components for localization in multiple source conditions. Evaluation results demonstrate that, although MUSIC with BCD yield comparable performance to that of WWG in conditions where single speech source exists, WWG with ISA surpasses the other methods in conditions including two or three speech sources. [ABSTRACT FROM AUTHOR]

Abstract: Temporal coding in the auditory nerve is strikingly transformed in the cochlear nucleus. In contrast to fibers in the auditory nerve, some neurons in the cochlear nucleus can show “picket fence” phase-locking to low-frequency pure tones: they fire a precisely timed action potential at every cycle of the stimulus. Such synchronization enhancement and entrainment is particularly prominent in neurons with the spherical and globular morphology, described by Osen [Osen KK (1969) Cytoarchitecture of the cochlear nuclei in the cat. J Comp Neurol 136:453–483]. These neurons receive large axosomatic terminals from the auditory nerve—the end bulbs and modified end bulbs of Held—and project to binaural comparator nuclei in the superior olivary complex. The most popular model to account for picket fence phase-locking is monaural coincidence detection. This mechanism is plausible for globular neurons, which receive a large number of inputs. We draw attention to the existence of enhanced phase-locking and entrainment in spherical neurons, which receive too few end-bulb inputs from the auditory nerve to make a coincidence detection of end-bulb firings a plausible mechanism of synchronization enhancement. [Copyright &y& Elsevier]

Abstract: It is well established that the responses of binaural auditory neurons can adapt and change dramatically depending on the nature of a preceding sound. Examples of how the effects of ensuing stimuli play a functional role in auditory processing include motion sensitivity and precedence-like effects. To date, these types of effects have been documented at the level of the midbrain and above. Little is known about sensitivity to ensuing stimuli below in the superior olivary nuclei where binaural response properties are first established. Here we report on single cell responses in the gerbil lateral superior olive, the initial site where sensitivity to interaural level differences is established. In contrast to our expectations we found a robust sensitivity to ensuing stimuli. The majority of the cells we tested (86%), showed substantial suppression and/or enhancement to a designated target stimulus, depending on the nature of a preceding stimulus. Hence, sensitivity to ensuing stimuli is already established at the first synaptic station of binaural processing. [Copyright &y& Elsevier]

Abstract: Sound pressure level changes can affect the timing of spiketrains. Timing of spiketrains is critical for sensitivity to interaural timing differences (ITDs). Interaural level differences (ILDs) can therefore affect the ITD cue. It has been hypothesized that ILDs may be coded indirectly through a peripheral conversion of level to time (but it should be cautioned that the changes in phase with SPL in low-CF AN fibers of the cat are more complicated) (Jeffress, L.A., 1948. A place theory of sound localization. J. Comp. Physiol. Psychol. 41, 35–39). We tested this conversion by recording from auditory nerve fibers to broadband noise at different SPLs. For each fiber, correlograms were constructed to compare timing to fine-structure across SPLs. We find generally a decrease in the time delay between spikes and the stimulus with increasing SPL. However, the magnitudes of the shift in time are surprisingly small, and dependent on characteristic frequency (CF): the largest shifts are approximately 10μs/dB and occur at the lowest CFs. Nevertheless, the effects of level on spike timing are systematic and of a magnitude to which the binaural system is sensitive. Thus, even though the results indicate that ILD is not traded for ITD in a simple way, the possibility that low-frequency ILDs affect the binaural percept via a peripheral level-to-time conversion cannot be excluded. [Copyright &y& Elsevier]

Bilateral cochlear implantation is intended to provide the advantages of binaural hearing, including sound localization and better speech recognition in noise. In most modern implants, temporal information is carried by the envelope of pulsatile stimulation, and thresholds to interaural time differences (ITDs) are generally high compared to those obtained in normal hearing observers. One factor thought to influence ITD sensitivity is the overlap of neural populations stimulated on each side. The present study investigated the effects of acoustically stimulating bilaterally mismatched neural populations in two related paradigms: rabbit neural recordings and human psychophysical testing. The neural coding of interaural envelope timing information was measured in recordings from neurons in the inferior colliculus of the unanesthetized rabbit. Binaural beat stimuli with a 1-Hz difference in modulation frequency were presented at the best modulation frequency and intensity as the carrier frequencies at each ear were varied. Some neurons encoded envelope ITDs with carrier frequency mismatches as great as several octaves. The synchronization strength was typically nonmonotonically related to intensity. Psychophysical data showed that human listeners could also make use of binaural envelope cues for carrier mismatches of up to 2-3 octaves. Thus, the physiological and psychophysical data were broadly consistent, and suggest that bilateral cochlear implants should provide information sufficient to detect envelope ITDs even in the face of bilateral mismatch in the neural populations responding to stimulation. However, the strongly nonmonotonic synchronization to envelope ITDs suggests that the limited dynamic range with electrical stimulation may be an important consideration for ITD encoding. [ABSTRACT FROM AUTHOR]

Abstract: Despite extensive subcortical processing, the auditory cortex is believed to be essential for normal sound localization. However, we still have a poor understanding of how auditory spatial information is encoded in the cortex and of the relative contribution of different cortical areas to spatial hearing. We investigated the behavioral consequences of inactivating ferret primary auditory cortex (A1) on auditory localization by implanting a sustained release polymer containing the GABAA agonist muscimol bilaterally over A1. Silencing A1 led to a reversible deficit in the localization of brief noise bursts in both the horizontal and vertical planes. In other ferrets, large bilateral lesions of the auditory cortex, which extended beyond A1, produced more severe and persistent localization deficits. To investigate the processing of spatial information by high-frequency A1 neurons, we measured their binaural-level functions and used individualized virtual acoustic space stimuli to record their spatial receptive fields (SRFs) in anesthetized ferrets. We observed the existence of a continuum of response properties, with most neurons preferring contralateral sound locations. In many cases, the SRFs could be explained by a simple linear interaction between the acoustical properties of the head and external ears and the binaural frequency tuning of the neurons. Azimuth response profiles recorded in awake ferrets were very similar and further analysis suggested that the slopes of these functions and location-dependent variations in spike timing are the main information-bearing parameters. Studies of sensory plasticity can also provide valuable insights into the role of different brain areas and the way in which information is represented within them. For example, stimulus-specific training allows accurate auditory localization by adult ferrets to be relearned after manipulating binaural cues by occluding one ear. Reversible inactivation of A1 resulted in slower and less complete adaptation than in normal controls, whereas selective lesions of the descending corticocollicular pathway prevented any improvement in performance. These results reveal a role for auditory cortex in training-induced plasticity of auditory localization, which could be mediated by descending cortical pathways. [Copyright &y& Elsevier]

Primary auditory cortex plays a crucial role in spatially directed behavior, but little is known about the effect of behavioral state on the neural representation of spatial cues. Macaques were trained to discriminate binaural cues to sound localization, eventually allowing measurement of thresholds comparable to human hearing. During behavior and passive listening, single units in low-frequency auditory cortex showed robust and consistent tuning to interaural phase difference (IPD). In most neurons, behavior exerted an effect on peak discharge rate (58% increased, 13% decreased), but this was not accompanied by a detectable shift in the best IPD of any cell. Neurometric analysis revealed a difference in discriminability between the behaving and passive condition in half of the sample (52%), but steepening of the neurometric function (29%) was only slightly more common than flattening (23%). This suggests that performance of a discrimination task does not necessarily confer an advantage in understanding the representation of the spatial cue in primary auditory cortex but nevertheless revealed some physiological effects. These results suggest that responses observed during passive listening provide a valid representation of neuronal response properties in core auditory cortex. [ABSTRACT FROM AUTHOR]

Abstract: Prepulse inhibition (PPI) of the startle reflex to binaural prepulse stimuli is reliably reported to be reduced in patients with schizophrenia. Monaural acoustic prestimuli produce more inhibition of the eye blink reflex than binaural prestimuli in healthy people. The effect of monaural prestimulation on reflex inhibition in patients with schizophrenia is not known. In this study, inhibition of the acoustic startle response by monaural and binaural acoustic prestimuli was assessed in 20 antipsychotic-naïve first episode schizophrenia patients and compared with 20 age and sex-matched healthy subjects. The results revealed less PPI, especially with binaural prestimuli, in patients than healthy subjects but both groups showed more PPI with monaural than binaural prestimuli. It is concluded that first episode schizophrenia patients show deficient sensorimotor gating but they are not impaired in the mechanism underlying stronger PPI with monaural than binaural prepulses. [Copyright &y& Elsevier]

The discrimination of a change in a stimulus is determined both by the magnitude of that change and by the variability in the neural response to the stimulus. When the stimulus is itself noisy, then the relative contributions of the neural (intrinsic) and stimulus induced variability becomes a critical question. We measured the contribution of intrinsic neural noise and interstimulus variability to the discrimination of interaural time differences (ITDs) and interaural correlation (IAC). We measured discharge rate versus characteristic frequency (CF) tone ITD functions, and CF-centered narrowband noise ITD and IAC functions in interleaved blocks in the same units in the inferior colliculus of urethane-anesthetized guinea pigs. Ten "frozen" tokens of noise were synthesized and the responses to each token were separately analyzed to allow the relative contributions of intrinsic and stimulus variability to be assessed. ITD and IAC discrimination thresholds were determined for a simulated two-interval forced-choice experiment, based on the firing rate distributions, using receiver operating characteristic analysis. On average, between stimulus variability contributed 19% (range, 1.5-30%) of the variance in noise ITD discrimination and 27% (range, 3-50%) in IAC discrimination. Noise ITD thresholds were slightly higher than tone ITD thresholds. Taking the mean of the thresholds for individual noise tokens gave a similar result to pooling across all noise tokens. This implies that although the stimulus induced variability is measurable, it is insignificant in relation to the intrinsic noise in ITD and IAC discrimination. [ABSTRACT FROM AUTHOR]

This study evaluated functional benefits from bilateral stimulation in 20 children ages 4–14, 10 use two CIs and 10 use one CI and one HA. Localization acuity was measured with the minimum audible angle (MAA). Speech intelligibility was measured in quiet, and in the presence of 2-talker competing speech using the CRISP forced-choice test. Results show that both groups perform similarly when speech reception thresholds are evaluated. However, there appears to be benefit (improved MAA and speech thresholds) from wearing two devices compared with a single device that is significantly greater in the group with two CI than in the bimodal group. Individual variability also suggests that some children perform similarly to normal-hearing children, while others clearly do not. Future advances in binaural fitting strategies and improved speech processing schemes that maximize binaural sensitivity will no doubt contribute to increasing the binaurally-driven advantages in persons with bilateral CIs. [ABSTRACT FROM AUTHOR]

Binaural hearing aids potentially provide binaural cues that can improve the dectability and the spatial separation of multiple sound sources. This paper considers the use of binaural cues and the resultant spatial percepts on listeners’ ability to separate simultaneous sound sources. In backgrounds with continuous noise or multiple talkers, the main problem is the detection of individual acoustic components. On the other hand, if a single masking sound is very similar to the target, and both target and masker are spectro-temporally sparse, as is the case with speech, the main problem, at least for listeners with normal hearing, is to decide whether a particular spectro-temporal feature belongs to the target source and to track that source across time. Although the subjective location of a sound source can help in grouping features across time, its effect is most easily observed in the absence of other differences between the sound sources. [ABSTRACT FROM AUTHOR]

Summary: Objective: The aim was to study the factors contributing to the mode of hearing aid use in children, with special emphasis on hearing loss variables and detection delay. Methods: The subjects were 328 children and adolescents (58.5% boys, 41.5% girls) aged 1–18 years with hearing loss of ≥30dB HL in the better ear fitted with hearing aid(s). The study was cross-sectional analysing the mode of using the aid binaurally/unilaterally or not at all. Results: The children with hearing-impairment ranging from 50 to 90dB HL used more regularly their hearing aids. In the subjects with hearing loss ≥80dB HL the presence of measurable hearing threshold at 4kHz related significantly to the acceptance of amplification (p =0.027). In 19% of the subjects hearing aid was discarded. Bilateral amplification was used in 38%. Unilateral use was the prevailing mode (44%). The younger the children (p =0.000) and the worse their hearing loss (p =0.008), the more regular their bilateral use was. Early detection of hearing loss and early hearing aid fitting promoted binaural hearing aid use (p =0.004). A marked asymmetry in pure tone thresholds was a significant audiological reason for fixed unilateral hearing device use (38%, p =0.001). Conclusions: The study shows that early detection of hearing loss and early habilitation of hearing increase bilateral use of hearing device and decrease the number of nonusers. Furthermore, residual unaided hearing at 4kHz significantly improves the use of device. [Copyright &y& Elsevier]

Binaural neurons show remarkable sensitivity to temporal differences in the waveforms at the two ears. This ability obviously requires temporal coding of sound waveforms in the monaural afferents that converge on such binaural neurons. We introduce a new analysis to investigate how well responses of single monaural neurons support discrimination of decorrelations in waveforms. Spike trains from auditory nerve (AN) and anteroventral cochlear nucleus (AVCN) neurons of cats to many repetitions of a set of broadband and narrowband noise tokens were obtained. The normalized correlation between the noise tokens ranged from 0.99 to -1. A coincidence and signal detection analysis was used to perform a correlation discrimination task using the monaural spike trains. The correlation discrimination thresholds derived from AVCN neurons were lower than those derived from AN fibers and sometimes as low as human psychophysical just noticeable differences. Importantly, low detection thresholds required comparisons of spike trains at small internal delays. Bandwidth dependence of neural decorrelation thresholds agreed with psychophysical data when large internal delays contributed to the detection. We conclude that, in the context of correlation discrimination, coding by AVCN fibers is superior to that by AN fibers and that these discriminations require a distribution of internal or best delays in binaural processing that differs from the predictions from studies of discrimination in interaural time delays. [ABSTRACT FROM AUTHOR]

This paper describes a perceptually motivated computational auditory scene analysis (CASA) system that combines sound separation according to spatial location with the "missing data" approach for robust speech recognition in noise. Missing data time-frequency masks are created using probability distributions based on estimates of interaural time and level differences (ITD and ILD) for mixed utterances in reverberated conditions; these masks indicate which regions of the spectrum constitute reliable evidence of the target speech signal. A number of experiments compare the relative efficacy of the binaural cues when used individually and in combination. We also investigate the ability of the system to generalize to acoustic conditions not encountered during training. Performance on a continuous digit recognition task using this method is found to be good, even in a particularly challenging environment with three concurrent male talkers. [ABSTRACT FROM AUTHOR]

In nature, sounds from multiple sources sum at the eardrums, generating complex cues for sound localization and identification. In this clutter, the auditory system must determine "what is where." We examined this process in the auditory space map of the barn owl's (Tyto alba) inferior colliculus using two spatially separated sources simultaneously emitting uncorrelated noise bursts, which were uniquely identified by different frequencies of sinusoidal amplitude modulation. Spatial response profiles of isolated neurons were constructed by testing the source-pair centered at various locations in virtual auditory space. The neurons responded whenever a source was placed within the receptive field, generating two clearly segregated foci of activity at appropriate loci. The spike trains were locked strongly to the amplitude modulation of the source within the receptive field, whereas the other source had minimal influence. Two sources amplitude modulated at the same rate were resolved successfully, suggesting that source separation is based on differences of fine structure. The spike rate and synchrony were stronger for whichever source had the stronger average binaural level. A computational model showed that neuronal activity was primarily proportional to the degree of matching between the momentary binaural cues and the preferred values of the neuron. The model showed that individual neurons respond to and synchronize with sources in their receptive field if there are frequencies having an average binaural-level advantage over a second source. Frequencies with interaural phase differences that are shared by both sources may also evoke activity, which may be synchronized with the amplitude modulations from either source. [ABSTRACT FROM AUTHOR]

Sensitivity to changes in the interaural correlation of 50-ms bursts of narrowband or broadband noise was measured in single neurons in the inferior colliculus of urethane-anaesthetized guinea pigs. Rate vs. interaural correlation functions (rICFs) were measured using two methods. These methods compensated in different ways for the inherent variance in interaural correlation between tokens with the same expected correlation. The shape of all rICFs could be best described by power functions allowing them to be summarized by two parameters. Most rICFs were best fit by a power below 2, indicating that they were only slightly nonlinear. However, there were a few fitted functions that had a power of 3-6, indicating marked curvature. Modeling results indicate that the nonlinearity of the majority of rICFs was explicable in terms of the monaural transduction stages; however, some of the rICFs with power greater than 2 require either multiple inputs to the coincidence detector or additional nonlinearities to be included in the model. Discrimination thresholds were estimated at reference correlations of -1, 0, and +1 using receiver operating characteristic (ROC) analysis of the spike-count distribution at each correlation. Thresholds spanned the full possible range, from a minimum of 0.1 to the maximum possible of 2. Thresholds were generally highest with a reference correlation of -1, intermediate with a reference of 0, and lowest with a reference correlation of +1. Thresholds were lowest for the most steeply sloped rICFs, but thresholds were not strongly correlated to the spike rate variance. The lowest thresholds occurred using narrowband noise that was compensated for internal delays, but they were still about three times larger than human psychophysical thresholds measured using similar stimuli. The data suggest that, unlike pure tone interaural time difference, discrimination of a population measure is required to account for behavioral interaural correlation discrimination performance. [ABSTRACT FROM AUTHOR]

Abstract: Objective: Binaural beat sensations depend upon a central combination of two different temporally encoded tones, separately presented to the two ears. We tested the feasibility to record an auditory steady state evoked response (ASSR) at the binaural beat frequency in order to find a measure for temporal coding of sound in the human EEG. Methods: We stimulated each ear with a distinct tone, both differing in frequency by 40Hz, to record a binaural beat ASSR. As control, we evoked a beat ASSR in response to both tones in the same ear. We band-pass filtered the EEG at 40Hz, averaged with respect to stimulus onset and compared ASSR amplitudes and phases, extracted from a sinusoidal non-linear regression fit to a 40Hz period average. Results: A 40Hz binaural beat ASSR was evoked at a low mean stimulus frequency (400Hz) but became undetectable beyond 3kHz. Its amplitude was smaller than that of the acoustic beat ASSR, which was evoked at low and high frequencies. Both ASSR types had maxima at fronto-central leads and displayed a fronto-occipital phase delay of several ms. Conclusions: The dependence of the 40Hz binaural beat ASSR on stimuli at low, temporally coded tone frequencies suggests that it may objectively assess temporal sound coding ability. The phase shift across the electrode array is evidence for more than one origin of the 40Hz oscillations. Significance: The binaural beat ASSR is an evoked response, with novel diagnostic potential, to a signal that is not present in the stimulus, but generated within the brain. [Copyright &y& Elsevier]

Binaural hearing offers several advantages over monaural hearing including improved speech understanding in the presence of background noise and the ability to localize the source of sounds. Patients who have undergone unilateral cochlear implantation perform poorly at these binaural tasks despite their improved hearing capabilities. Bilateral cochlear implants have restored these abilities in many adult patients. This study is designed to evaluate the degree to which similar benefits are realized by children who receive a second cochlear implant after successful experience with a first device. Twenty-five children aged 3–13 years underwent sequential bilateral cochlear implantation followed by a series of age appropriate speech reception tasks administered in quiet and in background noise. Some also underwent sound localization testing. The children demonstrated improved speech understanding in quiet and in noise using two cochlear implants when compared with either implant alone. Sound localization ability was poor in all subjects even after 9 months of bilateral implant use. We conclude that bilateral cochlear implantation offers potential benefits to children, especially with regard to hearing speech in noise. [Copyright &y& Elsevier]

This study investigated the extent to which 9 months of listening with bilateral cochlear implants (CIs) improves the ability of children to hear speech in noise and to localize sounds. Three children ages 8–12 who received sequential bilateral CIs, 3–8 years apart, participated in a series of binaural tasks at 3 and 9 months after activation of the second CI. Each child participated in a battery of tests under unilateral and bilateral conditions. Results suggest that speech intelligibility in noise improves with added bilateral experience, but that speech intelligibility in quiet does not. In addition, the improvement was seen primarily for the two younger children, who had received the second CI at the age of 8, but not for the older child whose second CI was received at the age of 12. None of the children were able to localize sounds well at 3 or 9 months after receiving the second CI. Further research is necessary to establish the importance of age of implantation and duration of bilateral experience necessary in order for maximal performance to be achieved. [Copyright &y& Elsevier]

Many clinics now recommend the trial of a hearing aid for the contralateral ear for adults with a cochlear implant (bimodal stimulation). This paper builds on earlier research and examines the utility of providing a hearing aid in the contralateral ear for adult cochlear implant users. Eight adults with a cochlear implant were fitted with an Oticon SUMO XP hearing aid. Performance was evaluated in terms of speech perception in quiet and noise (front, left and right), localisation performance (front, left and right) and subjective measures of benefit. Significant improvements were obtained for speech perception in both quiet and noise. For speech understanding in quiet, mean scores improved from 52% to 71% and in noise (+10 or +5 dB SNR) from 48% to 59%. While accurate localisation remained difficult, it was only with bimodal input that localisation ability was significantly above chance. Investigation of results from the Bimodal Benefit Questionnaire indicated the greatest perceived benefits were in terms of speech understanding in noise, localisation, perception of own voice, and perception of music. Following the study, all participants continued to wear the test hearing aid in combination with their cochlear implant and reported high satisfaction with bimodal stimulation. [Copyright &y& Elsevier]

Auditory space-specific neurons in the owl's inferior colliculus selectively respond to the direction of sound propagation, which is defined by combinations of interaural time (ITD) and level (ILD) differences. Mathematical analyses show that the amplitude of postsynaptic potentials in these neurons is a product of two components that vary with either ITD or ILD. Temporal correlation in the fine structure of signals between the ears is essential for detection of ITD. By varying the degree of binaural correlation, we could accurately change the amplitude of the ITD component of postsynaptic potentials in the space-specific neurons. Multiplication worked for the entire range of postsynaptic potentials created by manipulation of ITD. [ABSTRACT FROM AUTHOR]

Interaural time difference (ITD) is a cue to the location of sounds containing low frequencies and is represented in the inferior colliculus (IC) by cells that respond maximally at a particular best delay (BD). Previous studies have demonstrated that single ITD-sensitive cells contain sufficient information in their discharge patterns to account for ITD acuity on the midline (ITD = 0). If ITD discrimination were based on the activity of the most sensitive cell available ("lower envelope hypothesis"), then ITD acuity should be relatively constant as a function of ITD. In response to broadband noise, however, the ITD acuity of human listeners degrades as ITD increases. To account for these results, we hypothesize that pooling of information across neurons is an essential component of ITD discrimination. This report describes a neural pooling model of ITD discrimination based on the response properties of ITD-sensitive cells in the IC of anesthetized cats. Rate versus ITD curves were fit with a cross-correlation model of [TD sensitivity, and the parameters were used to constrain a population model of ITD discrimination. The model accurately predicts ITD acuity as a function of ITD for broadband noise stimuli when responses are pooled across best frequency (BF). Furthermore, ITD tuning based solely on a system of internal delays is not sufficient to predict ITD acuity in response to 500 Hz tones, suggesting that acuity is likely refined by additional mechanisms. The physiological data confirms evidence from the guinea pig that BD varies systematically with BF, generalizing the observation across species. [ABSTRACT FROM AUTHOR]

Barn owls use interaural intensity differences to localize sounds in the vertical plane. At a given elevation the magnitude of the interaural intensity difference cue varies with frequency, creating an interaural intensity difference spectrum of cues which is characteristic of that direction. To test whether space-specific cells are sensitive to spectral interaural intensity difference cues, pure-tone interaural intensity difference tuning curves were taken at multiple different frequencies for single neurons in the external nucleus of the inferior colliculus. For a given neuron, the interaural intensity differences eliciting the maximum response (the best interaural intensity differences) changed with the frequency of the stimulus by an average maximal difference of 9.4±6.2 dB. The resulting spectral patterns of these neurally preferred interaural intensity differences exhibited a high degree of similarity to the acoustic interaural intensity difference spectra characteristic of restricted regions in space. Compared to stimuli whose interaural intensity difference spectra matched the preferred spectra, stimuli with inverted spectra elicited a smaller response, showing that space-specific neurons are sensitive to the shape of the spectrum. The underlying mechanism is an inhibition for frequency-specific interaural intensity differences which differ from the preferred spectral pattern. Collectively, these data show that space-specific neurons are sensitive to spectral interaural intensity difference cues and support the idea that behaving barn owls use such cues to precisely localize sounds. [ABSTRACT FROM AUTHOR]

Adults and children (aged 5 years 1 month to 10 years 8 months) were tested in a masking-level difference (MLD) paradigm in which detection of brief signals was contrasted for signal placement in masker envelope maxima versus masker envelope minima. Maskers were 50-Hz-wide noise bands centered on 500 Hz, and the signals were So or Sπ 30-ms, 500-Hz tones. In agreement with previous studies, it was found that MLDs were greater for masker envelope minima placement than for masker envelope maxima placement. Across the age range of the children tested here, the binaural advantage associated with the masker envelope minima increased with the age of the child. One interpretation of the present results is that there is a developmental improvement in binaural temporal resolution over the age range tested here. [ABSTRACT FROM AUTHOR]

Background: Interaural level differences (ILD) and interaural time differences (ITD) are binaural cues used in sound localisation and in detection of signals in noisy backgrounds. People with asymmetric hearing loss have poor binaural processing skills. Discrimination performance in ILD and ITD tasks substantially improves with training. Training in binaural hearing may be of clinical benefit to certain populations. Objectives: (1) What is the role of perceptual learning in auditory training? (2) Which regime trains binaural cue discrimination most effectively? Methods: (1) Subjects were trained on an identical, adaptive ILD-discrimination task presented within different procedures in each of four groups, then tested on all procedures post-training. (2) Subjects underwent either blocked or distributed training in ILD or ITD discrimination and were tested at intervals post-training. Results: (1) There was no significant difference in task performance post-training between the groups. (2) ILD and ITD discrimination performance was not significantly different in the blocked and distributed training groups. Conclusions: Perceptual learning occurred rapidly in auditory training. Significant, lasting training effects were found for both ILD and ITD tasks, and both blocked and distributed regimes were equally effective. These findings will guide further work on the potential therapeutic use of auditory training. [Copyright &y& Elsevier]

The auditory motion aftereffect (aMAE) can be induced in listeners after repeated presentation of a horizontally moving sound source. Aftereffects have also been found for the individual acoustic consequences of source motion such as amplitude or frequency modulations (AM, FM). No study, however, has investigated whether combining these changes would enhance the magnitude of the aMAE, which has appeared otherwise weak relative to its visual counterpart. AM, FM and binaural changes can occur simultaneously when sources move along common translational trajectories rather than the restricted rotational paths used in previous adaptation studies. This raises the question whether the observed weakness of the aMAE is due to the improper stimulation of units responsive to the entire macrostructure induced by translational motion. The hypothesis is tested here that if integrated motion detectors exist, then including lawful amplitude and frequency changes in adapting stimuli may enhance aftereffects. Though results indicate that interaurally moving stimuli in general induce an aMAE, the acoustic macrostructure of translational motion does not appear to increase the aftereffect. A simple cross-correlation model is used to illustrate that such acoustic modulations may allow brainstem auditory centers time to recover from adaptation to translational motion. [Copyright &y& Elsevier]

The interaural time difference (ITD) is a major cue to sound localization along the horizontal plane. The maximum natural ITD occurs when a sound source is positioned opposite to one ear. We examined the ability of owls and humans to detect large ITDs in sounds presented through headphones. Stimuli consisted of either broad or narrow bands of Gaussian noise, 100 ms in duration. Using headphones allowed presentation of ITDs that are greater than the maximum natural ITD. Owls were able to discriminate a sound leading to the left ear from one leading to the right ear, for ITDs that are 5 times the maximum natural delay. Neural recordings from optic-tectum neurons, however, show that best ITDs are usually well within the natural range and are never as large as ITDs that are behaviorally discriminable. A model of binaural cross-correlation with short delay lines is shown to explain behavioral detection of large ITDs. The model uses curved trajectories of a cross-correlation pattern as the basis for detection. These trajectories represent side peaks of neural ITD-tuning curves and successfully predict localization reversals by both owls and human subjects. [ABSTRACT FROM AUTHOR]

Vestibular evoked myogenic potentials (VEMP) has been put forward as a test to evaluate the symmetry of saccular function. In the present study, the symmetry of VEMP was evaluated in 23 healthy subjects using automatic analysis. In response to binaural clicks with a stimulus repetition rate of 4/s all subjects revealed significant VEMP on both sides. The ipsilateral response to monaural clicks was similar to the response to binaural clicks. Although there were large interindividual variations in amplitude, there were only small variations in latency. VEMP measurements were also assessed using different stimulus rates. At the higher stimulus rates there was a decrease in the VEMP amplitude but there were only small changes in the latency. These findings might suggest that amplitude measures are more likely than latency measures to reveal small vestibular lesions. [ABSTRACT FROM AUTHOR]

Located in the midbrain, the inferior colliculus (IC) plays an essential role in many auditory computations, including speech processing and sound localization. The right and left sides of the IC are interconnected by a dense fiber tract, the commissure of the IC (CoIC), that provides each IC with one of its largest sources of input (i.e., the contralateral IC). Despite its prominence, the CoIC remains poorly understood. Previous studies using anterograde and retrograde tract-tracing showed that IC commissural projections are predominately homotopic and tonotopic, targeting mirror-image locations in the same frequency region in the contralateral IC. However, it is unknown whether specific classes of neurons, particularly inhibitory neurons which constitute ~10%-40% of the commissural projection, follow this pattern. We, therefore, examined the commissural projections of Neuropeptide Y (NPY) neurons, the first molecularly identifiable class of GABAergic neurons in the IC. Using retrograde tracing with Retrobeads (RB) in NPY-hrGFP mice of both sexes, we found that NPY neurons comprise ~11% of the commissural projection. Moreover, focal injections of Retrobeads showed that NPY neurons in the central nucleus of the IC exhibit a more divergent and heterotopic commissural projection pattern than non-NPY neurons. Thus, commissural NPY neurons are positioned to provide lateral inhibition to the contralateral IC. Through this circuit, sounds that drive activity in limited regions on one side of the IC likely suppress activity across a broader region in the contralateral IC., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Anair, Silveira, Mirjalili, Beebe, Schofield and Roberts.)

This paper discusses a machine learning approach for detecting SSVEP at both ears with minimal channels. SSVEP is a robust EEG signal suitable for many BCI applications. It is strong at the visual cortex around the occipital area, but the SNR gets worse when detected from other areas of the head. To make use of SSVEP measured around the ears following the ear-EEG concept, especially for practical binaural implementation, we propose a CNN structure coupled with regressed softmax outputs to improve accuracy. Evaluating on a public dataset, we studied classification performance for both subject-dependent and subject-independent trainings. It was found that with the proposed structure using a group training approach, a 69.21% accuracy was achievable. An ITR of 6.42 bit/min given 63.49 % accuracy was recorded while only monitoring data from T7 and T8. This represents a 12.47% improvement from a single ear implementation and illustrates potential of the approach to enhance performance for practical implementation of wearable EEG., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Israsena and Pan-Ngum.)