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203. SC307 - Limited vs extended lymph node dissection in T1G3 bladder cancer patients treated with radical cystectomy: is this group responsible for the negative results of the LEA trial?

Author

Basile, G., Bandini, M., Zaffuto, E., Scuderi, S., Dehò, F., Salonia, A., Matloob, R., Burgio, G., Sciacqua, L., Bertini, R., Comana, S., Moschini, M., Zamboni, S., Afferi, L., Scattoni, V., Colombo, R., Briganti, A., Montorsi, F., Necchi, A., and Gallina, A.

Published
2020
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215. Extent of lymph node dissection at nephrectomy affects cancer-specific survival and metastatic progression in specific sub-categories of patients with renal cell carcinoma (RCC)

Author

Capitanio U, Suardi N, Matloob R, Roscigno M, Abdollah F, Di Trapani E, Moschini M, Gallina A, SALONIA , ANDREA, Briganti A, MONTORSI , FRANCESCO, Bertini R., Capitanio, U, Suardi, N, Matloob, R, Roscigno, M, Abdollah, F, Di Trapani, E, Moschini, M, Gallina, A, Salonia, Andrea, Briganti, A, Montorsi, Francesco, and Bertini, R.

Subjects
Adult, Male, renal cell carcinoma, Adolescent, Urology, lymph node dissection, lymph node invasion, survival, Nephrectomy, Disease-Free Survival, Young Adult, cancer-specific survival, Carcinoma, Renal Cell, Aged, Neoplasm Staging, Aged, 80 and over, Neoplasm Invasivene, kidney cancer, metastases progression-free survival, Kidney Neoplasm, Middle Aged, Survival Rate, metastase, lymphadenectomy, Lymph Node Excision, Female, Cohort Studie, Human
Abstract

Objective To test whether the number of lymph nodes removed affects cancer-specific survival (CSS) or metastatic progression-free survival (MPFS) in different renal cell carcinoma (RCC) scenarios. Methods We used Cox regression analyses to analyse the effect of the number of lymph nodes removed on CSS and MPFS in 1983 patients with RCC treated with nephrectomy. To adjust for possible clinical and surgical selection bias, analyses were further adjusted for number of positive nodes, presence of metastases, age, performance status, T stage, tumour size and grade. Results The prevalence of lymph node invasion was 6.1%. The mean follow-up period was 83.3 months. Multivariable analyses showed that the number of nodes removed had an independent, protective effect on CSS in patients with pT2a-pT2b or pT3c-pT4 RCC (hazard ratio [HR] 0.91, P = 0.008 and HR 0.89, P < 0.001, respectively), in patients with bulky tumours (tumour size >10 cm, HR 0.97, P = 0.03) or when sarcomatoid features were found (HR 0.81, P = 0.006). The removal of each additional lymph node was associated with a 3-19% increase in CSS. When considering MPFS as an endpoint, the number of nodes removed had an independent, protective effect in the same patient categories. Conclusions When clinically indicated, the number of nodes removed affects CSS and MPFS in specific sub-categories of patients with RCC. © 2013 The Authors. BJU International © 2013 BJU International.

Published
2014

216. Transverse target spin asymmetries in exclusive $ ho^0$ muoproduction

Author

Adolph, C., Alekseev, M. G., Alexakhin, V. Y. u., Alexandrov, Y. u., Alexeev, G. D., Amoroso, A., Andrieux, V., Austregesilo, A., Badellek, B., Balestra, F., Barth, J., Baum, G., Bedfer, Y., Berlin, A., Bernhard, J., Bertini, R., Bicker, K., Bieling, J., Birsa, R., Bisplinghoff, J., Boer, M., Bordalo, P., Bradamante, Franco, Braun, C., Bravar, A., Bressan, Andrea, Buechele, M., Burtin, E., Capozza, L., Chiosso, M., Chung, S. U., Cicuttin, A., Crespo, M. L., Dalla Torre, S., Dasgupta, S. S., Dasgupta, S., Denisov, O. Y. u., Donskov, S. V., Doshita, N., Duic, Venicio, Duennweber, W., Dziewiecki, M., Efremov, A., Elia, Carmine, Eversheim, P. D., Eyrich, W., Faessler, M., Ferrero, A., Filin, A., Finger, M., Finger~jr, M., Fischer, H., Franco, C., Du~fresne~von~hohenesche, N., Friedrich, J. M., Frolov, V., Garfagnini, R., Gautheron, F., Gavrichtchouk, O. P., Gerassimov, S., Geyer, R., Giorgi, Marcello, Gnesi, I., Gobbo, B., Goertz, S., Grabmueller, S., Grasso, A., Grube, B., Gushterski, R., Guskov, A., Guthoerl, T., Haas, F., von Harrach, D., Hahne, D., Heinsius, F. H., Herrmann, F., Hess, C., Hinterberger, F., Hoeppner, C. h., Horikawa, N., D'Hose, N., Huber, S., Ishimoto, S., Ivanshin, Y. u., Iwata, T., Jahn, R., Jary, V., Jasinski, P., Joosten, R., Kabuss, E., Kang, D., Ketzer, B., Khaustov, G. V., Khokhlov, Y. u. A., Kisselev, Y. u., Klein, F., Klimaszewski, K., Koivuniemi, J. H., Kolosov, V. N., Kondo, K., Koenigsmann, K., Konorov, I., Konstantinov, V. F., Kotzinian, A. M., Kouznetsov, O., Kraemer, M., Kroumchtein, Z. V., Kuchinski, N., Kunne, F., Kurek, K., Kurjata, R. P., Lednev, A. A., Lehmann, A., Levorato, Stefano, Lichtenstadt, J., Maggiora, A., Magnon, A., Makke, Nour, Mallot, G. K., Marchand, C., Martin, Anna, Marzec, J., Matousek, Jan, Matsuda, H., Matsuda, T., Meshcheryakov, G., Meyer, W., Michigami, T., Mikhailov, Y. u. V., Miyachi, Y., Morreale, A., Nagaytsev, A., Nagel, T., Nerling, F., Neubert, S., Neyret, D., Nikolaenko, V. I., Novy, J., Nowak, W. D., Nunes, A. S., Olshevsky, A. G., Ostrick, M., Panknin, R., Panzieri, D., Parsamyan, B., Paul, S., Pesek, M., Piragino, G., Platchkov, S., Pochodzalla, J., Polak, J., Polyakov, V. A., Pretz, J., Quaresma, M., Quintans, C., Ramos, S., Reicherz, G., Rocco, Elena, Rodionov, V., Rondio, E., Rossiyskaya, N. S., Ryabchikov, D. I., Samoylenko, V. D., Sandacz, A., Sapozhnikov, M. G., Sarkar, S., Savin, I. A., Sbrizzai, Giulio, Schiavon, Paolo, Schill, C., Schlueter, T., Schmidt, A., Schmidt, K., Schmitt, L., Schmieden, H., Schoenning, K., Schopferer, S., Schott, M., Shevchenko, O. Y. u., Silva, L., Sinha, L., Sirtl, S., Slunecka, M., Sosio, S., Sozzi, Federica, Srnka, A., Steiger, L., Stolarski, M., Sulc, M., Sulej, R., Suzuki, H., Sznajder, P., Takekawa, S., Ter~wolbeek, J., Tessaro, Susanna, Tessarotto, F., Thibaud, F., Uhl, S., Uman, I., Vandenbroucke, M., Virius, M., Vondra, J., Wang, L., Weisrock, T., Wilfert, M., Windmolders, R., Wislicki, W., Wollny, H., Zaremba, K., Zavertyaev, M., Zemlyanichkina, E., Zhuravlev, N., Ziembicki, M., Adolph, C., Alekseev, M. G., Alexakhin, V. Y. u., Alexandrov, Y. u., Alexeev, G. D., Amoroso, A., Andrieux, V., Austregesilo, A., Badellek, B., Balestra, F., Barth, J., Baum, G., Bedfer, Y., Berlin, A., Bernhard, J., Bertini, R., Bicker, K., Bieling, J., Birsa, R., Bisplinghoff, J., Boer, M., Bordalo, P., Bradamante, Franco, Braun, C., Bravar, A., Bressan, Andrea, Buechele, M., Burtin, E., Capozza, L., Chiosso, M., Chung, S. U., Cicuttin, A., Crespo, M. L., Dalla Torre, S., Dasgupta, S. S., Dasgupta, S., Denisov, O. Y. u., Donskov, S. V., Doshita, N., Duic, Venicio, Duennweber, W., Dziewiecki, M., Efremov, A., Elia, Carmine, Eversheim, P. D., Eyrich, W., Faessler, M., Ferrero, A., Filin, A., Finger, M., Finger~jr, M., Fischer, H., Franco, C., Du~fresne~von~hohenesche, N., Friedrich, J. M., Frolov, V., Garfagnini, R., Gautheron, F., Gavrichtchouk, O. P., Gerassimov, S., Geyer, R., Giorgi, Marcello, Gnesi, I., Gobbo, B., Goertz, S., Grabmueller, S., Grasso, A., Grube, B., Gushterski, R., Guskov, A., Guthoerl, T., Haas, F., von Harrach, D., Hahne, D., Heinsius, F. H., Herrmann, F., Hess, C., Hinterberger, F., Hoeppner, C. h., Horikawa, N., D'Hose, N., Huber, S., Ishimoto, S., Ivanshin, Y. u., Iwata, T., Jahn, R., Jary, V., Jasinski, P., Joosten, R., Kabuss, E., Kang, D., Ketzer, B., Khaustov, G. V., Khokhlov, Y. u. A., Kisselev, Y. u., Klein, F., Klimaszewski, K., Koivuniemi, J. H., Kolosov, V. N., Kondo, K., Koenigsmann, K., Konorov, I., Konstantinov, V. F., Kotzinian, A. M., Kouznetsov, O., Kraemer, M., Kroumchtein, Z. V., Kuchinski, N., Kunne, F., Kurek, K., Kurjata, R. P., Lednev, A. A., Lehmann, A., Levorato, Stefano, Lichtenstadt, J., Maggiora, A., Magnon, A., Makke, Nour, Mallot, G. K., Marchand, C., Martin, Anna, Marzec, J., Matousek, Jan, Matsuda, H., Matsuda, T., Meshcheryakov, G., Meyer, W., Michigami, T., Mikhailov, Y. u. V., Miyachi, Y., Morreale, A., Nagaytsev, A., Nagel, T., Nerling, F., Neubert, S., Neyret, D., Nikolaenko, V. I., Novy, J., Nowak, W. D., Nunes, A. S., Olshevsky, A. G., Ostrick, M., Panknin, R., Panzieri, D., Parsamyan, B., Paul, S., Pesek, M., Piragino, G., Platchkov, S., Pochodzalla, J., Polak, J., Polyakov, V. A., Pretz, J., Quaresma, M., Quintans, C., Ramos, S., Reicherz, G., Rocco, Elena, Rodionov, V., Rondio, E., Rossiyskaya, N. S., Ryabchikov, D. I., Samoylenko, V. D., Sandacz, A., Sapozhnikov, M. G., Sarkar, S., Savin, I. A., Sbrizzai, Giulio, Schiavon, Paolo, Schill, C., Schlueter, T., Schmidt, A., Schmidt, K., Schmitt, L., Schmieden, H., Schoenning, K., Schopferer, S., Schott, M., Shevchenko, O. Y. u., Silva, L., Sinha, L., Sirtl, S., Slunecka, M., Sosio, S., Sozzi, Federica, Srnka, A., Steiger, L., Stolarski, M., Sulc, M., Sulej, R., Suzuki, H., Sznajder, P., Takekawa, S., Ter~wolbeek, J., Tessaro, Susanna, Tessarotto, F., Thibaud, F., Uhl, S., Uman, I., Vandenbroucke, M., Virius, M., Vondra, J., Wang, L., Weisrock, T., Wilfert, M., Windmolders, R., Wislicki, W., Wollny, H., Zaremba, K., Zavertyaev, M., Zemlyanichkina, E., Zhuravlev, N., and Ziembicki, M.

Subjects
polarization, gpd, exclusive reactions, hemp
Abstract

Exclusive production of ρ0ρ0 mesons was studied at the COMPASS experiment by scattering 160 GeV/c160 GeV/c muons off transversely polarised protons. Five single-spin and three double-spin azimuthal asymmetries were measured as a function of Q2Q2, xBjxBj, or View the MathML sourcepT2. The View the MathML sourcesinϕS asymmetry is found to be −0.019±0.008(stat.)±0.003(syst.)−0.019±0.008(stat.)±0.003(syst.). All other asymmetries are also found to be of small magnitude and consistent with zero within experimental uncertainties. Very recent calculations using a GPD-based model agree well with the present results. The data is interpreted as evidence for the existence of chiral-odd, transverse generalized parton distributions.

Published
2014

217. Transverse target spin asymmetries in exclusive <math altimg='si1.gif' xmlns='http://www.w3.org/1998/Math/MathML'><msup><mrow><mi>ρ</mi></mrow><mrow><mn>0</mn></mrow></msup></math> muoproduction

Author

Guthoerl, T., Paul, S., T. Nagel, A.M. Kotzinian, S. Gerassimov, Hohenesche, N. du Fresne von, Olshevsky, A.G.(Joint Institute for Nuclear Research, Moscow Region, Dubna, 141980, Russia), Quintans, C., Silva, L., Finger, M, Elia, C., Bedfer, Y., B. Grube, Quaresma, M., Balestra, F., F. Gautheron, Austregesilo, A., Badellek, B., Wang, L., Kabuss, E., Doshita, N., Matsuda, H.(Yamagata University, Yamagata, 992-8510, Japan), Sirtl, S., Kunne, F., Schlueter, T., Koivuniemi, J. H., S. Takekawa, V.A. Polyakov, Ziembicki, M., Berlin, A., Garfagnini, R.(University of Turin, Department of Physics, Turin, 10125, Italy), Huber, S., Nunes, A.S.(LIP, Lisbon, 1000-149, Portugal), Lednev, A. A., Dasgupta, S., Gavrichtchouk, O. P., Levorato, S.(Trieste Section of INFN, Trieste, 34127, Italy), Kurek, K., Ishimoto, S., Chung, S U., Thibaud, F.(CEA IRFU/SPhN Saclay, Gif-sur-Yvette, 91191, France), Mikhailov, Yu.V.(State Research Center of the Russian Federation, Institute for High Energy Physics, Protvino, 142281, Russia), V. Andrieux, M. Faessler, Crespo, M.L.(Abdus Salam ICTP, Trieste, 34151, Italy), Capozza, L., Guskov, A., Kouznetsov, O., Ramos, S., Platchkov, S.(CEA IRFU/SPhN Saclay, Gif-sur-Yvette, 91191, France), Shevchenko, O. Yu., Dziewiecki, M., Matsuda, T, V.N. Kolosov, K. Klimaszewski, Eyrich, W., Rodionov, V., E. Zemlyanichkina, Ostrick, M., Khokhlov, Yu. A., N.S. Rossiyskaya, Haas, F., Cicuttin, A., P. Jasinski, Efremov, A.(Joint Institute for Nuclear Research, 141980, Moscow region, Dubna, Russia), Ketzer, B., Sozzi, F., Friedrich, J.M., Schmidt, K, J. Bieling, Meyer, W, Filin, A., Kroumchtein, Z. V., Martin, A., Lichtenstadt, J., Ferrero, A., Khaustov, G. V., Fischer, H., Buechele, M., I.A. Savin, Grasso, A., Bressan, A., Slunecka, M., Srnka, A., J. Matousek, Rocco, E., S. Neubert, Sarkar, S., Konstantinov, V. F., Bertini, R., Makke, N., E. Burtin, Schmieden, H., Sandacz, A., Adolph, C., Hinterberger, F., Goertz, S., Vondra, J., Franco, C, A. Amoroso, Alexakhin, V. Yu., F. Nerling, Kisselev, Yu.(Joint Institute for Nuclear Research, Dubna, Moscow Region, 141980, Russia), T. Iwata, Sapozhnikov, M. G., Gnesi, I., Miyachi, Y., Alexandrov, Yu., Duennweber, W., Rondio, E., Kondo, K., Nowak, W.-D., Lehmann, A.(Universität Erlangen–Nürnberg, Physikalisches Institut, Erlangen, 91054, Germany), Kang, D., Frolov, V., Schiavon, P., M. Giorgi, Baum, Günter, Kurjata, R. P., Meshcheryakov, G., Donskov, S. V., Reicherz, G., Joosten, R., Parsamyan, B., Wilfert, M., Neyret, D., M. Vandenbroucke, Boer, M., V.I. Nikolaenko, Marchand, C., Dasgupta, S.S.(Matrivani Institute of Experimental Research & Education, Calcutta-700 030, India 12 12 Supported by SAIL (CSR), Govt. of India.), Michigami, T., Ryabchikov, D.I., Pretz, J., S. Sosio, Suzuki, H, Kraemer, M., M.G. Alekseev, Eversheim, P. D., jr, M. Finger, Hoeppner, Ch., Schott, M, Gushterski, R., Hess, C, Zhuravlev, N., Maggiora, A., Panknin, R., Zaremba, K., Heinsius, F. H., S. Schopferer, Tessaro, S., Wollny, H., K. Schoenning(Uppsala University), Bisplinghoff, J., Sznajder, P., Steiger, L.(Trieste Section of INFN, 34127, Trieste, Italy), A. Morreale, Schmidt, A., Barth, J., Samoylenko, V. D., Konorov, I., Mallot, G. K., Marzec, J., Pesek, M.(Charles University in Prague, Faculty of Mathematics and Physics, Prague, 18000, Czech Republic), Torre, S. Dalla, Virius, M.(Czech Technical University in Prague, Prague, 16636, Czech Republic), P. Bordalo, Bradamante, F., Stolarski, M., Harrach, D. von, M. Sulc, Gobbo, B., Jary, V., Koenigsmann, K., Zavertyaev, M., W. Wislicki, Sinha, L., C. Schill, Panzieri, D.(University of Eastern Piedmont, Alessandria, 15100, Italy), Sulej, R., Grabmueller, S., Jahn, R.(Universität Bonn, Helmholtz-Institut für Strahlen- und Kernphysik, Bonn, 53115, Germany), Polak, J, Pochodzalla, J., Windmolders, R., Ivanshin, Yu., Birsa, R., Bicker, K., Magnon, A.(CEA IRFU/SPhN Saclay, 91191 Gif-sur-Yvette, France 17), Tessarotto, F., M. Chiosso, R. Geyer, Alexeev, G.D., Horikawa, N., d'Hose, N., Denisov, O.Yu., Klein, F.(Physikalisches Institut, Universität Bonn, Bonn, 53115, Germany), Braun, C., Piragino, G., Kuchinski, N., S. Uhl, G. Sbrizzai, Schmitt, L, Weisrock, T., F. Herrmann, Wolbeek, J. Ter, Novy, J, Bravar, A.(University of Geneva, Section de Physique, DPNC, Geneva, Switzerland), Nagaytsev, A., Uman, I.(Dogus University, Istanbul, 34722, Turkey), Duic, V., Hahne, D., and J. Bernhard

Subjects
Physik, Nuclear and High Energy Physics, ddc:530, Nuclear Experiment, Particle Physics - Experiment, High Energy Physics - Experiment
Abstract

Exclusive production of ρ0 mesons was studied at the COMPASS experiment by scattering 160 GeV/c muons off transversely polarised protons. Five single-spin and three double-spin azimuthal asymmetries were measured as a function of Q2 , xBj , or pT2 . The sinϕS asymmetry is found to be −0.019±0.008(stat.)±0.003(syst.) . All other asymmetries are also found to be of small magnitude and consistent with zero within experimental uncertainties. Very recent calculations using a GPD-based model agree well with the present results. The data is interpreted as evidence for the existence of chiral-odd, transverse generalized parton distributions.

Published
2016

218. Elective Nephron Sparing Surgery Decreases Other-Causes Mortality Relative to Radical Nephrectomy Only in Specific Subgroups of Patients with Renal Cell Carcinoma: Impact of Nephron Sparing Surgery on Non-Cancer Mortality

Author

Larcher, A, Capitanio, U, Terrone, C, Volpe, A, De Angelis, P, Deho, F, Fossati, N, Dell'Oglio, P, Antonelli, Alberto, Furlan, M, Simeone, C, Serni, Sergio, Carini, Marco, Minervini, Andrea, Fiori, C, Porpiglia, F, Briganti, A, Montorsi, F, and Bertini, R.

Subjects
Kidney, Carcinoma, Renal Cell, Nephrectomy, Cause of Death,Ccomorbidity
Published
2016

219. LA CHIRURGIA RENALE CONSERVATIVA RIDUCE LA MORTALITÀ NON TUMORE-SPECIFICA RISPETTO A NEFRECTOMIA RADICALE SOLAMENTE IN ALCUNI SOTTOGRUPPI DI PAZIENTI CON CARCINOMA RENALE

Author

Larcher, A., Muttin, F., Capitanio, U., Terrone, C., Volpe, A., De Angelis, P., Dehò, F., Fossati, N., Antonelli, A., Furlan, M., Dell’Oglio, P., Simeone, C., Serni, S., Carini, M., Minervini, A., Fiori, C., Porpiglia, F., Briganti, A., Montorsi, F., and Bertini, R.

Subjects
CHIRURGIA RENALE CONSERVATIVA, NEFRECTOMIA RADICALE, CARCINOMA RENALE
Published
2016

220. Nephron sparing surgery decreases other-causes mortality relative to radical nephrectomy only in specific subgroups of patients with renal cell carcinoma

Author

Larcher, A., Capitanio, U., Terrone, C., Dehò, F., Volpe, A., Antonelli, A., Minervini, Andrea, Fiori, C., Furlan, M., Serni, Sergio, Carini, Marco, Novara, G., Porpiglia, F., Simeone, C., Fossati, N., Briganti, A., Montorsi, F., and Bertini, R.

Subjects
Nephron sparing surgery, Radical nephrectomy, Renal cell carcinoma
Published
2016

222. Comparison of robot-assisted and open surgery partial nephrectomy: an observational prospective study on functional and oncologic outcomes

Author

Larcher, A., primary, Capitanio, U., additional, Fossati, N., additional, De Naeyer, G., additional, De Groote, R., additional, Bianchi, L., additional, Turri, F.M., additional, Guazzoni, G., additional, Salonia, A., additional, Briganti, A., additional, Bertini, R., additional, Montorsi, F., additional, and Mottrie, A., additional

Published
2017
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223. Perioperative morbidity and complications after robot-assisted and open surgery partial nephrectomy: An observational prospective study

Author

Fossati, N., primary, Capitanio, U., additional, De Naeyer, G., additional, De Groote, R., additional, Bianchi, L., additional, Turri, F.M., additional, Guazzoni, G., additional, Salonia, A.R., additional, Briganti, A., additional, Bertini, R., additional, Montorsi, F., additional, and Mottrie, A., additional

Published
2017
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225. Proposal and validation of a dynamic criterion for patient inclusion in kidney cancer active surveillance protocols

Author

Larcher, A., primary, Muttin, F., additional, Ripa, F., additional, Stabile, A., additional, Trevisani, F., additional, Nini, A., additional, La Croce, G., additional, Carenzi, C., additional, Mottrie, A., additional, Salonia, A., additional, Briganti, A., additional, Montorsi, F., additional, Bertini, R., additional, and Capitanio, U., additional

Published
2017
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226. Does prostate cancer represent the main cause of death in all node positive prostate cancer patients? The impact of competing causes of mortality according to tumor characteristics and recurrence status

Author

Dell’Oglio, P., primary, Zaffuto, E., additional, Stabile, A., additional, Gandaglia, G., additional, Colicchia, M., additional, Fossati, N., additional, Capitanio, U., additional, Dehò, F., additional, Colombo, R., additional, Bertini, R., additional, Montorsi, F., additional, Karnes, J., additional, and Briganti, A., additional

Published
2017
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227. The ability of three comorbity indeces to predict postosperative mortality in renal cell carcinoma patients: The impending need of a new disease-specific index

Author

Dell’Oglio, P., primary, Larcher, A., additional, Muttin, F., additional, Fossati, N., additional, Nini, A., additional, Ripa, F., additional, La Croce, G., additional, Trevisani, F., additional, Carenzi, C., additional, Salonia, A., additional, Briganti, A., additional, Montorsi, F., additional, Bertini, R., additional, and Capitanio, U., additional

Published
2017
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228. Long-term assessment of mortality patterns after surgical treatment for non-metastatic kidney cancer: A competing risk analysis

Author

Larcher, A., primary, Muttin, F., additional, Nini, A., additional, Trevisani, F., additional, Ripa, F., additional, Cianflone, F., additional, Carenzi, C., additional, Dell'Oglio, P., additional, Rigatti, P., additional, Dehó, F., additional, Montorsi, F., additional, Capitanio, U., additional, and Bertini, R., additional

Published
2017
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229. The effect of anatomical location of retroperitoneal lymph node metastases on cancer specific survival in patients with clear cell renal cell carcinoma

Author

Nini, A., primary, Larcher, A., additional, Terrone, C., additional, Volpe, A., additional, Muttin, F., additional, Ripa, F., additional, Regis, F., additional, Lucianò, R., additional, Briganti, A., additional, Bertini, R., additional, Montorsi, F., additional, and Capitanio, U., additional

Published
2017
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230. Comparison of robot-assisted and open surgery partial nephrectomy: An observational prospective study on pathologic and early functional outcomes

Author

Larcher, A., primary, Capitanio, U., additional, Fossati, N., additional, De Naeyer, G., additional, De Groote, R., additional, Umari, P., additional, Trevisani, F., additional, Guazzoni, G., additional, Salonia, A., additional, Briganti, A., additional, Bertini, R., additional, Montorsi, F., additional, and Mottrie, A., additional

Published
2017
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231. Is a preoperative low ejection fraction a risk factor for complications and impaired survival in renal cancer patients who undergo surgery? Results from a propensity-score matching with non cardiopathic counterparts

Author

Nini, A., primary, Larcher, A., additional, Muttin, F., additional, Zaffuto, E., additional, Dell’Oglio, P., additional, Ripa, F., additional, Carenzi, C., additional, La Croce, G., additional, Oppizzi, M., additional, Fragasso, G., additional, Montorsi, F., additional, Capitanio, U., additional, and Bertini, R., additional

Published
2017
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232. Impact of intraoperative blood transfusions on survival after surgery for renal cell carcinoma

Author

La Croce, G., primary, Muttin, F., additional, Moschini, M., additional, Larcher, A., additional, Dell’Oglio, P., additional, Nini, A., additional, Ripa, F., additional, Cianflone, F., additional, Di Trapani, E., additional, Carenzi, C., additional, Dehò, F., additional, Montorsi, F., additional, Bertini, R., additional, and Capitanio, U., additional

Published
2017
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233. Predictive and prognostic effect of inflammatory lymphadenopathies in renal cell carcinoma

Author

Pecoraro, A., primary, Larcher, A., additional, Nini, A., additional, Muttin, F., additional, Stabile, A., additional, Di Trapani, E., additional, Carenzi, C., additional, Trevisani, F., additional, De Cobelli, F., additional, Gaboardi, F., additional, Guazzoni, G., additional, Briganti, A., additional, Montorsi, F., additional, Bertini, R., additional, and Capitanio, U., additional

Published
2017
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234. On-clamp versus off-clamp partial nephrectomy: Propensity score matched comparison of long term functional outcomes

Author

Simone, G., primary, Capitanio, U., additional, Larcher, A., additional, Ferriero, M., additional, Misuraca, L., additional, Tuderti, G., additional, Romeo, G., additional, Minisola, F., additional, Guaglianone, S., additional, Muttin, F., additional, Nini, A., additional, Trevisani, F., additional, Montorsi, F., additional, Bertini, R., additional, and Gallucci, M., additional

Published
2017
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235. First repeated biopsy represents the most informative predictor of progression-free survival at 3 years follow-up in patients included in an active surveillance protocol for low-risk prostate cancer

Author

Luzzago, S., primary, Suardi, N., additional, Dell’Oglio, P., additional, Fossati, N., additional, Capitanio, U., additional, Gandaglia, G., additional, Zaffuto, E., additional, Mirone, V., additional, Bertini, R., additional, Damiano, R., additional, Freschi, M., additional, Gaboardi, F., additional, Montorsi, F., additional, and Briganti, A., additional

Published
2017
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237. Spin asymmetry A1d and the spin-dependent structure function g1d of the deuteron at low values of x and Q2

Author

Alexakhin, V.Yu., Alexandrov, Yu., Alexeev, G.D., Amoroso, A., Badełek, B., Balestra, F., Ball, J., Baum, G., Bedfer, Y., Bernet, C., Bertini, R., Birsa, R., Bisplinghoff, J., Bordalo, P., Bradamante, F., Bravar, A., Bressan, A., Brona, G., Burtin, E., Bussa, M.P., Chapiro, A., Cicuttin, A., Colantoni, M., Costa, S., Crespo, M.L., d'Hose, N., Dalla Torre, S., Dasgupta, S.S., De Masi, R., Denisov, O.Yu., Dhara, L., Diaz Kavka, V., Dinkelbach, A.M., Donskov, S.V., Dorofeev, V.A., Doshita, N., Duic, V., Dünnweber, W., Eversheim, P.D., Eyrich, W., Fabro, M., Faessler, M., Falaleev, V., Ferrero, A., Ferrero, L., Finger, M., Finger Jr., M., Fischer, H., Franz, J., Friedrich, J.M., Frolov, V., Garfagnini, R., Gautheron, F., Gavrichtchouk, O.P., Gerassimov, S., Geyer, R., Giorgi, M., Gobbo, B., Goertz, S., Gorin, A.M., Grajek, O.A., Grasso, A., Grube, B., Hannappel, J., von Harrach, D., Hasegawa, T., Heckmann, J., Hedicke, S., Heinsius, F.H., Hermann, R., Heß, C., Hinterberger, F., von Hodenberg, M., Horikawa, N., Horikawa, S., Ilgner, C., Ioukaev, A.I., Ishimoto, S., Ivanov, O., Iwata, T., Jahn, R., Janata, A., Joosten, R., Jouravlev, N.I., Kabuß, E., Kang, D., Ketzer, B., Khaustov, G.V., Khokhlov, Yu.A., Khomutov, N.V., Kisselev, Yu., Klein, F., Koblitz, S., Koivuniemi, J.H., Kolosov, V.N., Komissarov, E.V., Kondo, K., Königsmann, K., Konorov, I., Konstantinov, V.F., Korentchenko, A.S., Korzenev, A., Kotzinian, A.M., Koutchinski, N.A., Kravchuk, N.P., Kroumchtein, Z.V., Kuhn, R., Kunne, F., Kurek, K., Ladygin, M.E., Lamanna, M., Le Goff, J.M., Lichtenstadt, J., Liska, T., Ludwig, I., Maggiora, A., Maggiora, M., Magnon, A., Mallot, G.K., Marchand, C., Marroncle, J., Martin, A., Marzec, J., Matsuda, T., Maximov, A.N., Meyer, W., Mielech, A., Mikhailov, Yu.V., Moinester, M.A., Nähle, O., Nassalski, J., Neliba, S., Neyret, D.P., Nikolaenko, V.I., Nozdrin, A.A., Obraztsov, V.F., Olshevsky, A.G., Ostrick, M., Padee, A., Pagano, P., Panebianco, S., Panzieri, D., Paul, S., Peshekhonov, D.V., Peshekhonov, V.D., Piragino, G., Platchkov, S., Pochodzalla, J., Polyakov, V.A., Popov, A.A., Pretz, J., Procureur, S., Quintans, C., Ramos, S., Reicherz, G., Rozhdestvensky, A.M., Rondio, E., Sadovski, A.B., Samoylenko, V.D., Sandacz, A., Sapozhnikov, M.G., Savin, I.A., Schiavon, P., Schill, C., Schmitt, L., Shevchenko, O.Yu., Shishkin, A.A., Siebert, H.-W., Sinha, L., Sissakian, A.N., Slunecka, M., Smirnov, G.I., Sozzi, F., Sugonyaev, V.P., Srnka, A., Stinzing, F., Stolarski, M., Sulc, M., Sulej, R., Takabayashi, N., Tchalishev, V.V., Tessarotto, F., Teufel, A., Tkatchev, L.G., Virius, M., Vlassov, N.V., Webb, R., Weise, E., Weitzel, Q., Windmolders, R., Wirth, S., Wiślicki, W., Zaremba, K., Zhao, J., Ziegler, R., and Zvyagin, A.

Subjects
Nuclear and High Energy Physics
Published
2007
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239. When to perform preoperative bone scan for kidney cancer staging

Author

Larcher, A., primary, Muttin, F., additional, Nini, A., additional, Dell’oglio, P., additional, Fossati, N., additional, Suardi, N., additional, Stabile, A., additional, Carenzi, C., additional, Trevisani, F., additional, Salonia, A., additional, Briganti, A., additional, Bertini, R., additional, Montorsi, F., additional, and Capitanio, U., additional

Published
2016
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240. Decreased transcriptional activity of Calcium-sensing receptor gene promoter 1 is associated with calcium nephrolithiasis

Author

Vezzoli G, Terranegra A, Aloia A, Arcidiacono T, Milanesi L, Mosca E, Mingione A, Spotti D, Cusi D, Hou J, Hendy GN, Soldati L, Paloschi V, Dogliotti E, Brasacchio C, Dell'Antonio G, Montorsi F, Bertini R, Bellinzoni P, Guazzoni G, Borghi L, Guerra A, Allegri F, Ticinesi A, Meschi T, Nouvenne A, Lupo A, Fabris A, Gambaro G, Rendina D, De Filippo G, Brandi ML, Croppi E, Cianferotti L, Trinchieri A, Caudarella R, Cupisti A, Anglani F, Del Prete D, GENIAL network, STRAZZULLO, PASQUALE, Vezzoli, G, Terranegra, A, Aloia, A, Arcidiacono, T, Milanesi, L, Mosca, E, Mingione, A, Spotti, D, Cusi, D, Hou, J, Hendy, Gn, Soldati, L, Paloschi, V, Dogliotti, E, Brasacchio, C, Dell'Antonio, G, Montorsi, F, Bertini, R, Bellinzoni, P, Guazzoni, G, Borghi, L, Guerra, A, Allegri, F, Ticinesi, A, Meschi, T, Nouvenne, A, Lupo, A, Fabris, A, Gambaro, G, Strazzullo, Pasquale, Rendina, D, De Filippo, G, Brandi, Ml, Croppi, E, Cianferotti, L, Trinchieri, A, Caudarella, R, Cupisti, A, Anglani, F, Del Prete, D, and Genial, Network

Subjects
Male, Transcription, Genetic, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Kidney, Biochemistry, Endocrinology, Receptors, Site-Directed, Settore MED/14 - NEFROLOGIA, Hypercalciuria, strontium, Promoter Regions, Genetic, transcription factor, messenger RNA, Single Nucleotide, Middle Aged, unclassified drug, Calcium-Sensing, Female, Calcium-sensing receptor, Transcription, Adult, medicine.medical_specialty, Calcium Nephrolithiasis, Genotype, chemistry.chemical_element, Single-nucleotide polymorphism, Calcium, Biology, Nephrolithiasis, Polymorphism, Single Nucleotide, Promoter Regions, Genetic, Internal medicine, medicine, claudin, CaSR, Humans, Endocrine Research, Polymorphism, Gene, Transcription factor, Alleles, Calcium sensing receptor, Biochemistry (medical), HEK 293 cells, Promoter, claudin 14, CaSR, Calcium Nephrolithiasis, kidney, medicine.disease, Molecular biology, HEK293 Cells, chemistry, Mutagenesis, Case-Control Studies, Mutagenesis, Site-Directed, Receptors, Calcium-Sensing
Abstract

BACKGROUND: CaSR gene is a candidate for calcium nephrolithiasis. Single-nucleotide polymorphisms (SNPs) encompassing its regulatory region were associated with calcium nephrolithiasis. AIMS: We tested SNPs in the CaSR gene regulatory region associated with calcium nephrolithiasis and their effects in kidney. SUBJECTS AND METHODS: One hundred sixty-seven idiopathic calcium stone formers and 214 healthy controls were genotyped for four CaSR gene SNPs identified by bioinformatics analysis as modifying transcription factor binding sites. Strontium excretion after an oral load was tested in 55 stone formers. Transcriptional activity induced by variant alleles at CaSR gene promoters was compared by luciferase reporter gene assay in HEK-293 and HKC-8 cells. CaSR and claudin-14 mRNA levels were measured by real-time PCR in 107 normal kidney medulla samples and compared in patients with different CaSR genotype. RESULTS: Only rs6776158 (A>G), located in the promoter 1, was associated with nephrolithiasis. Its minor G allele was more frequent in stone formers than controls (37.8% vs 26.4%, P = .001). A reduced strontium excretion was observed in GG homozygous stone formers. Luciferase fluorescent activity was lower in cells transfected with the promoter 1 including G allele at rs6776158 than cells transfected with the A allele. CaSR mRNA levels were lower in kidney medulla samples from homozygous carriers for the G allele at rs6776158 than carriers for the A allele. Claudin-14 mRNA levels were also lower in GG homozygous subjects. CONCLUSIONS: Minor allele at rs6776158 may predispose to calcium stones by decreasing transcriptional activity of the CaSR gene promoter 1 and CaSR expression in kidney tubules.

Published
2013

241. Staging lymphadenectomy in renal cell carcinoma must be extended: a sensitivity curve analysis

Author

Capitanio U, Suardi N, Matloob R, Abdollah F, Castiglione F, BRIGANTI , ALBERTO, Carenzi C, Roscigno M, MONTORSI , FRANCESCO, Bertini R., Capitanio, U, Suardi, N, Matloob, R, Abdollah, F, Castiglione, F, Briganti, Alberto, Carenzi, C, Roscigno, M, Montorsi, Francesco, and Bertini, R.

Abstract

Objective To investigate the staging of lymphadenectomy in renal cell carcinoma. No convincing data exist regarding the minimum number of lymph nodes that should be removed at the time of nephrectomy to ensure an accurate staging. Methods Between 1987 and 2011, 850 patients with renal cell carcinoma underwent either partial or radical nephrectomy plus lymph node dissection (LND) at a single tertiary care institution (T(any)N0-1M(any)). Receiver operating characteristic curve coordinates were used to graph the probability of finding lymph node invasion according to the number of removed lymph nodes. Assuming that the likelihood of finding lymph node invasion according to the number of lymph nodes removed may be affected by patient characteristics, analyses were further stratified for clinical and pathological characteristics. Results The rate of lymph node metastases strongly correlated with the clinical and pathological characteristics of the patients. Fifteen lymph nodes need to be removed to achieve a 90% probability of detecting at least one metastatic lymph node. Only slight differences were recorded after stratification for clinical nodal status, the presence of metastases at diagnosis and pathological T stage. Finally, 13, 16 and 21 lymph nodes need to be removed to achieve a 90% probability of detecting lymph node invasion, if present, in the low risk (score 0-1), intermediate risk (score 2-3) and high risk (score 4-5) Mayo Clinic classification, respectively.

Published
2013

242. Effect of number and location of distant metastases on renal cell carcinoma mortality in candidates for cytoreductive nephrectomy: Implications for multimodal therapy

Author

Capitanio, U, Abdollah, F, Matloob, R, Salonia, A, Suardi, N, Briganti, A, Carenzi, C, Rigatti, P, Montorsi, F, Bertini, R, Capitanio, U, Abdollah, F, Matloob, R, Salonia, Andrea, Suardi, N, Briganti, Alberto, Carenzi, C, Rigatti, P, Montorsi, Francesco, and Bertini, R.

Subjects
Cancer-specific survival, Urology, Metastase, Kidney Neoplasm, Cytoreductive surgery, Nephrectomy, Carcinoma, Renal Cell, Renal cell carcinoma, Human
Abstract

Objective To test whether the combination of number and location of distant metastases affects cancer-specific survival in patients with metastatic renal cell carcinoma. Methods Overall, 242 metastatic renal cell carcinoma patients with synchronous metastases at diagnosis underwent cytoreductive nephrectomy at a single institution. Combinations of number and location of distant metastases were coded as: single metastasis and single organ affected, multiple metastases and single organ affected, single metastasis for each of the multiple organs affected, and multiple metastases for each of the multiple organs affected. Covariates included age, symptoms, performance status, American Society of Anesthesiologists score, hemoglobin, lactate dehydrogenase, tumor size, Fuhrman grade, T stage, lymph node status, necrosis, sarcomatoid features and metastasectomy at the time of nephrectomy. Results The median survival was 34.7 versus 32.3 versus 29.6 versus 8.5months for single metastasis and single organ affected, multiple metastases and single organ affected single metastasis for each of the multiple organs affected, and multiple metastases for each of the multiple organs affected patients, respectively. At multivariable analyses, the combination of number and location of distant metastases resulted in one of the most informative and independent predictors of cancer-specific survival in metastatic renal cell carcinoma patients. The lung was the location with the highest rate of single organ affected (50.3% vs 35.1% in other sites; P

Published
2013

243. When to perform lymph node dissection in patients with renal cell carcinoma: a novel approach to the preoperative assessment of risk of lymph node invasion at surgery and of lymph node progression during follow-up

Author

Capitanio U, Abdollah F, Matloob R, Suardi N, Castiglione F, Di Trapani E, Capogrosso P, Gallina A, Dell'Oglio P, BRIGANTI , ALBERTO, SALONIA , ANDREA, MONTORSI , FRANCESCO, Bertini R., Capitanio, U, Abdollah, F, Matloob, R, Suardi, N, Castiglione, F, Di Trapani, E, Capogrosso, P, Gallina, A, Dell'Oglio, P, Briganti, Alberto, Salonia, Andrea, Montorsi, Francesco, and Bertini, R.

Subjects
Neoplasm Invasivene, renal cell carcinoma, lymph node progression, Urology, Kidney Neoplasm, lymph node dissection, Lymphatic Metastasi, lymph node invasion, Middle Aged, RCC, Risk Assessment, Follow-Up Studie, nomogram, Retrospective Studie, lymphadenectomy, Preoperative Care, Disease Progression, Lymph Node Excision, Carcinoma, Renal Cell, Human
Abstract

Objective To identify preoperatively patients who might benefit from lymph node dissection (LND). Patients and Methods We assessed lymph node invasion (LNI) at final pathology and lymph node (LN) progression during the follow-up for 1983 patients with RCC, treated with either partial or radical nephrectomy. LN progression was defined as the onset of a new clinically detected lymphadenopathy (>10mm) in the retroperitoneal lymphatic area. Logistic regression analyses were used to assess the effect of each potential clinical predictor (age, body mass index, tumour side, symptoms, performance status, clinical tumour size, clinical tumour-node-metastasis stage, and albumin, calcium, creatinine, haemoglobin and platelet levels) on the outcome of interest. The most parsimonious multivariable predictive model was developed, and discrimination, calibration and net benefit were calculated. Results The prevalence of LNI was 6.1% (120/1983 patients) and during the follow-up period, 82 patients (4.1%) experienced LN progression. On multivariable analyses, the most informative independent predictors were tumour stage (cT3-4 vs cT1-2, odds ratio [OR] 1.52, P = 0.05), clinical nodal status [cN1 vs cN0, OR 7.09, P < 0.001], metastases at diagnosis (OR 3.04, P < 0.001) and clinical tumour size (OR 1.14, P < 0.001). The accuracy of the multivariable model was found to be 86.9%, with excellent calibration and net benefit at decision-curve analyses. Conclusions By relying on a unique approach, combining the risk of harbouring LNI and/or LN progression during the follow-up period, we have provided the first clinical presurgery model predicting the need for LND.

Published
2013

244. Impact of the introduction of a robotic training programme on prostate cancer stage migration at a single tertiary referral centre

Author

Briganti, A, Bianchi, M, Sun, M, Suardi, N, Gallina, A, Abdollah, F, Bertini, R, Colombo, R, Di Girolamo, V, Salonia, A, Scattoni, V, Karakiewicz, Pi, Guazzoni, G, Rigatti, P, Montorsi, F, Briganti, Alberto, Bianchi, M, Sun, M, Suardi, N, Gallina, A, Abdollah, F, Bertini, R, Colombo, R, Girolamo, Vd, Salonia, Andrea, Scattoni, V, Karakiewicz, Pi, Guazzoni, G, Rigatti, P, and Montorsi, Francesco

Subjects
Male, Prostatectomy, Urology, Medicine (all), Tertiary Care Center, Middle Aged, prostate cancer, radical prostatectomy, minimally invasive treatment, Robotic, Italy, Retrospective Studie, Prostatic Neoplasm, Education, Medical, Continuing, Aged, Human, Neoplasm Staging, Program Evaluation
Abstract

What's known on the subject? and What does the study add? Previous studies have retrospectively compared functional and oncological outcomes between robot-assisted radical prostatectomy (RARP) and open retropubic radical prostatectomy (RRP), reporting non-inferior or superior outcomes associated with the use of the robotic approach. The study demonstrates that baseline selection biases makes comparisons of RARP and RRP problematic. Patients treated with RARP may have significantly better baseline characteristics than patients treated with RRP. Indeed, when both facilities are available within the same centre, patients with the most favourable clinical and cancer profile are inherently selected to RARP. In the absence of a prospective randomized trial, the decision to prefer one approach over another should be tailored according to each single patient and surgeon. Objective To evaluate the trend in robot-assisted radical prostatectomy (RARP) and open retropubic radical prostatectomy (RRP) use over time and to compare preoperative and pathological characteristics of patients treated with RARP or RRP at a single centre. Patients and Methods Between 2006 and 2010, 2511 consecutive patients treated with RP, with or without pelvic lymph node dissection (PLND), for prostate cancer (PCa) at a single tertiary care centre were analysed. Baseline patient characteristics and PCa risk distribution were compared according to treatment type (RRP vs RARP) in the overall population, as well as in three surgeons' initial 50 RARP and three surgeons' initial 50 RRP cases (n = 300). We used a chi-squared trend test to evaluate the differences in treatment type administration over time according to PCa characteristics. Logistic regression analyses focused on the prediction of PLND and adjuvant radiotherapy (RT) use. Results Overall, 1873 (74.6%) and 638 (25.4%) patients underwent RRP and RARP, respectively. Men treated with RARP were younger (mean age: 62 vs 65 years), less obese (mean BMI: 24.8 vs 26.4kg/m2), healthier (Charlson comorbidity index = 0: 68.7 vs 53.3%) and more likely to harbour clinical low-risk PCa (51 vs 30%) than their RRP counterparts (all P < 0.001). Similar findings were observed in sub-analyses focusing on six surgeons' 50 initial patients (all P 0.02). A significant increase in the rate of patients with low-risk PCa treated with RARP vs RRP was reported over time (5 vs 95% and 66 vs 34% in 2006 and 2010, respectively). Conversely, 76% of patients with high risk PCa were still treated with RRP in 2010. Patients treated with RARP were less likely to receive PLND at RP and adjuvant RT (all P 0.01), even after adjusting for clinical and PCa characteristics. Conclusions The introduction of a robotic training programme at a high volume centre led to significant patient selection in terms of clinical and PCa characteristics. When both RRP and RARP facilities are available within the same centre, patients with the most favourable clinical and cancer profile are selected to undergo RARP. Use of RARP negatively influenced the rates and the extent of PLND as well as the use of adjuvant RT after surgery. Thus, baseline patient selection, surgical and treatment biases make any comparisons of RARP with RRP problematic.

Published
2013

245. Time to recurrence is a significant predictor of cancer-specific survival after recurrence in patients with recurrent renal cell carcinoma - Results from a comprehensive multi-centre database (CORONA/SATURN-Project)

Author

Brookman May, S., May, M., Shariat, S., Novara, Giacomo, Zigeuner, R., Cindolo, L., Cobelli, O. D., Nunzio, C. D., Pahernik, S., Wirth, M., Longo, N., Simonato, A., Serni, S., Siracusano, S., Volpe, A., Morgia, G., Bertini, R., Dalpiaz, O., Stief, C., Ficarra, Vincenzo, Brookman-May, S. D., May, M., Shariat, S. F., Novara, G., Zigeuner, R., Cindolo, L., De Cobelli, O., De Nunzio, C., Pahernik, S., Wirth, M. P., Longo, N., Simonato, A., Serni, S., Siracusano, S., Volpe, A., Morgia, G., Bertini, R., Dalpiaz, O., Stief, C., Ficarra, V., Sabine D., Brookman May, Matthias, May, Shahrokh F., Shariat, Giacomo, Novara, Richard, Zigeuner, Luca, Cindolo, Ottavio De, Cobelli, Cosimo De, Nunzio, Sascha, Pahernik, Manfred P., Wirth, Nicola, Longo, Alchiede, Simonato, Sergio, Serni, Siracusano, Salvatore, Alessandro, Volpe, Giuseppe, Morgia, Roberto, Bertini, Orietta, Dalpiaz, Christian, Stief, Vincenzo, Ficarra, Brookman-May, Sabine D., May, Matthias, Shariat, Shahrokh F., Novara, Giacomo, Zigeuner, Richard, Cindolo, Luca, De Cobelli, Ottavio, De Nunzio, Cosimo, Pahernik, Sascha, Wirth, Manfred P., Longo, Nicola, Simonato, Alchiede, Serni, Sergio, Volpe, Alessandro, Morgia, Giuseppe, Bertini, Roberto, Dalpiaz, Orietta, Stief, Christian, and Ficarra, Vincenzo

Subjects
Male, renal cell carcinoma, Time Factors, Time Factor, Databases, Factual, Prognosi, Urology, prognostic parameter, early recurrence, time to recurrence, cancer-specific survival, Retrospective Studie, late recurrence, nephrectomy, Humans, cancer survival, Carcinoma, Renal Cell, renal cell carcinoma (RCC), prognostic parameters, Aged, Retrospective Studies, Kidney Neoplasm, Middle Aged, Prognosis, Kidney Neoplasms, Survival Rate, Female, Neoplasm Recurrence, Local, renal cell carcinoma (rcc), Human
Abstract

Objectives To assess the prognostic impact of time to recurrence (TTR) on cancer-specific survival (CSS) after recurrence in patients with renal cell carcinoma (RCC) undergoing radical nephrectomy or nephron-sparing surgery. To analyse differences in clinical and histopathological criteria between patients with early and late recurrence. Patients and Methods Of 13 107 patients with RCC from an international multicentre database, 1712 patients developed recurrence in the follow-up (FU), at a median (interquartile range) of 50.1 (25-106) months. In all, 1402 patients had recurrence at ≤5 years (Group A) and 310 patients beyond this time (Group B). Differences in clinical and histopathological variables between patients with early and late recurrence were analysed. The influence of TTR and further variables on CSS after recurrence was assessed by Cox regression analysis. Results Male gender, advanced age, tumour diameter and stage, Fuhrman grade 3-4, lymphovascular invasion (LVI), and pN + stage were significantly more frequent in patients with early recurrence, who had a significantly reduced 3-year CSS of 30% compared with patients in Group B (41%; P = 0.001). Age, gender, tumour histology, pT stage, and continuous TTR (hazard ratio 0.99, P = 0.006; monthly interval) independently predicted CSS. By inclusion of dichotomised TTR in the multivariable model, a significant influence of this variable on CSS was present until 48 months after surgery, but not beyond this time. Conclusions Advanced age, male gender, larger tumour diameters, LVI, Fuhrman grade 3-4, pN + stage, and advanced tumour stages are associated with early recurrence. Up to 4 years from surgery, a shorter TTR independently predicts a reduced CSS after recurrence. © 2013 The Authors. BJU International © 2013 BJU International.

Published
2013

246. Erratum to: Hadron transverse momentum distributions in muon deep inelastic scattering at 160 GeV/c [European Physical Journal C, 73, 2531, (2013), DOI:10.1140/epjc/s10052-013-2531-6]

Author

Adolph, C, Alekseev, MG, Alexakhin, VY, Alexandrov, Y, Alexeev, GD, Amoroso, A, Andrieux, V, Austregesilo, A, Badełek, B, Balestra, F, Barth, J, Baum, G, Bedfer, Y, Berlin, A, Bernhard, J, Bertini, R, Bicker, K, Bieling, J, Birsa, R, Bisplinghoff, J, Boer, M, Bordalo, P, Bradamante, F, Braun, C, Bravar, A, Bressan, A, Büchele, M, Burtin, E, Capozza, L, Chiosso, M, Chung, SU, Cicuttin, A, Crespo, ML, Dalla Torre, S, Dasgupta, SS, Dasgupta, S, Denisov, OY, Donskov, SV, Doshita, N, Duic, V, Dünnweber, W, Dziewiecki, M, Efremov, A, Elia, C, Eversheim, PD, Eyrich, W, Faessler, M, Ferrero, A, Filin, A, Finger, M, Finger Jr, M, Fischer, H, Franco, C, du Fresne von Hohenesche, N, Friedrich, JM, Frolov, V, Garfagnini, R, Gautheron, F, Gavrichtchouk, OP, Gerassimov, S, Geyer, R, Giorgi, M, Gnesi, I, Gobbo, B, Goertz, S, Grabmüller, S, Grasso, A, Grube, B, Gushterski, R, Guskov, A, Guthörl, T, Haas, F, von Harrach, D, Heinsius, FH, Herrmann, F, Heß, C, Hinterberger, F, Höppner, C, Horikawa, N, d’Hose, N, Huber, S, Ishimoto, S, Ivanshin, Y, Iwata, T, Jahn, R, Jary, V, Jasinski, P, Joosten, R, Kabuß, E, Kang, D, Ketzer, B, Khaustov, GV, Khokhlov, YA, Kisselev, Y, Klein, F, and Klimaszewski, K

Published
2015

247. Nephron-sparing surgery protects from chronic kidney disease relative to radical nephrectomy but does not impact on other-causes mortality: Long-term (more than 10 years) survival and functional outcomes in patients with a T1a-T1b renal mass

Author

Capitanio, U., Terrone, C., Antonelli, A., Minervini, Andrea, Porpiglia, F., Di Domenico, A., Furlan, M., Di Trapani, E., Salonia, A., Carini, Marco, Simeone, Felice Carlo, Montorsi, F., and Bertini, R.

Subjects
Nephron-sparing surgery ,radical nephrectomy, T1a-T1b renal mass
Published
2015

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