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201. K − meson production in the proton–proton reaction at 3.67 GeV/ c

Author

Balestra, F., Bedfer, Y., Bertini, R., Bland, L.C., Brenschede, A., Brochard, F., Bussa, M.P., Tchalyshev, V., Choi, Seonho, Debowski, M., Dzemidzic, M., Faivre, J.-Cl., Falomkin, I.V., Fava, L., Ferrero, L., Foryciarz, J., Fröhlich, I., Frolov, V., Garfagnini, R., Gill, D., Grasso, A., Grosse, E., Heinz, S., Ivanov, V.V., Jacobs, W.W., Kühn, W., Maggiora, A., Maggiora, M., Manara, A., Panzieri, D., Pfaff, H.-W., Piragino, G., Pontecorvo, G.B., Popov, A., Ritman, J., Salabura, P., Tosello, F., Vigdor, S.E., and Zosi, G.

Published
1999
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202. DISTO: a large acceptance multiparticle spectrometer for 1–3 GeV proton beams

Author

Balestra, F., Bedfer, Y., Bertini, R., Bland, L.C., Brenschede, A., Brochard, F., Bussa, M.P., Chalyshev, V., Choi, Seonho, Debowski, M., Dzemidzic, M., Faivre, J.Cl., Falomkin, I.V., Fava, L., Ferrero, L., Foryciarz, J., Frolov, V., Garfagnini, R., Gill, D., Grasso, A., Grosse, E., Heinz, S., Jacobs, W.W., Kühn, W., Maggiora, A., Maggiora, M., Manara, A., Panzieri, D., Pfaff, H.W., Piragino, G., Pontecorvo, G.B., Popov, A., Ritman, J., Salabura, P., Senger, P., Stroth, J., Tosello, F., Vigdor, S.E., Zalikhanov, B., and Zosi, G.

Published
1999
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203. Elective partial nephrectomy is equivalent to radical nephrectomy in patients with clinical T1 renal cell carcinoma: results of a retrospective, comparative, multi-institutional study

Author

Antonelli, A., Ficarra, V., Bertini, R., Carini, M., Carmignani, G., Corti, S., Longo, N., Martorana, G., Minervini, A., Mirone, V., Novara, G., Serni, S., Simeone, Claudio, Simonato, A., Siracusano, S., Volpe, A., Zattoni, F., Cunico, S. C., The, m. o., Antonelli, Alessandro, Ficarra, Vincenzo, Bertini, Roberto, Carini, Marco, Carmignani, Giorgio, Corti, Serena, Longo, Nicola, Martorana, Giuseppe, Minervini, Andrea, Mirone, Vincenzo, Novara, Giacomo, Serni, Sergio, Simeone, Claudio, Simonato, Alchiede, Siracusano, Salvatore, Volpe, Alessandro, Zattoni, Filiberto, Cunico, Sergio Cosciani, Antonelli, A, Ficarra, V, Bertini, R, Carini, M, Carmignani, G, Corti, S, Martorana, G, Minervini, A, Novara, G, Serni, S, Simeone, C, Simonato, A, Siracusano, S, Volpe, A, Zattoni, F, Cunico, Sc, Antonelli A, Ficarra V, Bertini R, Carini M, Carmignani G, Corti S, Longo N, Martorana G, Minervini A, Mirone V, Novara G, Serni S, Simeone C, Simonato A, Siracusano S, Volpe A, Zattoni F, Cunico SC, members of the SATURN Project - LUNA Foundation., A., Antonelli, V., Ficarra, R., Bertini, M., Carini, G., Carmignani, S., Corti, N., Longo, G., Martorana, A., Minervini, V., Mirone, G., Novara, S., Serni, C., Simeone, A., Simonato, A., Volpe, F., Zattoni, and S. C., Cunico

Subjects
Male, renal cell carcinoma, partial nephrectomy, renal cancer, Nephrectomy, methods, Elective, clinical staging, nephron-sparing surgery, radical nephrectomy, nephrectomy, Humans, Carcinoma, Renal Cell, Surgical Procedures, Elective Surgical Procedure, Carcinoma, Renal Cell, Elective partial nephrectomy is equivalent to radical nephrectomy in patients with clinical T1 renal cell carcinoma, Kidney Neoplasm, Middle Aged, Kidney Neoplasms, Survival Rate, mortality/pathology/surgery, Elective Surgical Procedures, Female, mortality/pathology/surgery, Female, Humans, Kidney Neoplasms, mortality/pathology/surgery, Male, Middle Aged, Nephrectomy, methods, Surgical Procedures, Elective, Survival Rate, Human
Abstract

Study Type - Therapy (cohort) Level of Evidence 2b What's known on the subject? and What does the study add? Few studies supported the expanded indications for nephron-sparing surgery (NSS) in selected patients with 4.1 cm renal tumours in the size range (T1b). However, all these comparative studies included both imperative and elective partial nephrectomy and patient selection for analysis was based on pathological stage (pT1) and not on clinical stage (cT1). Patients with clinically organ-confined RCC (cT1) who are candidates for elective PN have a limited risk of clinical understaging. NSS is not associated with an increased risk of recurrence and cancer-specific mortality both in cT1a and cT1b tumours OBJECTIVE: • To compare the oncological outcomes of patients who underwent elective partial nephrectomy (PN) or radical nephrectomy (RN) for clinically organ-confined renal masses ≤7 cm in size (cT1). PATIENTS AND METHODS: • The records of 3480 patients with cT1N0M0 disease were extracted from a multi-institutional database and analyzed retrospectively. RESULTS: • In patients who underwent PN, the risk of clinical understaging was 3.2% in cT1a cases and 10.6% in cT1b cases. • With regard to the cT1a patients, the 5- and 10-year cancer-specific survival (CSS) estimates were 94.7% and 90.4%, respectively, after RN and 96.1% and 94.9%, respectively, after PN (log-rank test: P = 0.01). • With regard to cT1b patients, the 5-year CSS probabilities were 92.6% after RN and 90% after PN, respectively (log-rank test: P = 0.89). • Surgical treatment failed to be an independent predictor of CSS on multivariable analysis, both for cT1a and cT1b patients. • Interestingly, PN was oncologically equivalent to RN also in patients with pT3a tumours (log-rank test: P = 0.91). CONCLUSIONS: • Elective PN is not associated with an increased risk of recurrence and cancer-specific mortality in both cT1a and cT1b tumours. • Data from the present study strongly support the use of partial nephrectomy in patients with clinically T1 tumours, according to the current recommendations of the international guidelines.

Published
2011

204. Erratum: Validation of the 2009 TNM version in a large multi-institutional cohort of patients treated for renal cell carcinoma: Are further improvements needed? (European Urology (2010) 58 (588-95))

Author

Novara, G, Ficarra, V, Antonelli, A, Artibani, W, Bertini, R, Carini, M, Cosciani Cunico, S, Imbimbo, C, Longo, N, Martignoni, G, Martorana, G, Minervini, A, Mirone, V, Montorsi, F, Schiavina, R, Simeone, C, Serni, S, Simonato, A, Siracusano, S, Volpe, A, Carmignani, G, SATURN Project-LUNA, Foundation., Novara G., Ficarra V., Antonelli A., Artibani W., Bertini R., Carini M., Cunico S.C., Imbimbo C., Longo N., Martignoni G., Martorana G., Minervini A., Mirone V., Montorsi F., Schiavina R., Simeone C., Serni S., Simonato A., Siracusano S., Volpe A., Carmignani G., NOVARA G, FICARRA V, ANTONELLI A, ARTIBANI W, BERTINI R, CARINI M, COSCIANI CUNICO S, IMBIMBO C, LONGO N, MARTIGNONI G, MARTORANA G, MINERVINI A, MIRONE V, MONTORSI F, SCHIAVINA R., SIMEONE C, SERNI S, SIMONATO A, SIRACUSANO S, VOLPE A, CARMIGNANI G, SATURN PROJECT-LUNA FOUNDATION., Novara, G, Ficarra, V, Antonelli, A, Artibani, W, Bertini, R, Carini, M, Cosciani Cunico, S, Imbimbo, C, Longo, N, Martignoni, G, Martorana, G, Minervini, A, Mirone, V, Montorsi, F, Schiavina, R, Simeone, C, Serni, S, Simonato, A, Siracusano, Salvatore, Volpe, A, Carmignani, G, and SATURN Project LUNA, Foundation

Subjects
Oncology, medicine.medical_specialty, Corrigendum to ‘‘Validation of the 2009 TNM Version in a Large, business.industry, Urology, Renal Cell Carcinoma, medicine.disease, TNM, Renal cell carcinoma, Internal medicine, Cohort, medicine, business, erratum error priority journal
Abstract

A new edition of the TNM was recently released that includes modifications for the staging system of kidney cancers. Specifically, T2 cancers were subclassified into T2a and T2b (< or =10 cm vs >10 cm), tumors with renal vein involvement or perinephric fat involvement were classified as T3a cancers, and those with adrenal involvement were classified as T4 cancers. OBJECTIVE: Our aim was to validate the recently released edition of the TNM staging system for primary tumor classification in kidney cancer. DESIGN, SETTING, AND PARTICIPANTS: Our multicenter retrospective study consisted of 5339 patients treated in 16 academic Italian centers. INTERVENTION: Patients underwent either radical or partial nephrectomy. MEASUREMENTS: Univariable and multivariable Cox regression models addressed cancer-specific survival (CSS) after surgery. RESULTS AND LIMITATIONS: In the study, 1897 patients (35.5%) were classified as pT1a, 1453 (27%) as pT1b, 437 (8%) as pT2a, 153 (3%) as pT2b, 1059 (20%) as pT3a, 117 (2%) as pT3b, 26 (0.5%) as pT3c, and 197 (4%) as pT4. At a median follow-up of 42 mo, 786 (15%) had died of disease. In univariable analysis, patients with pT2b and pT3a tumors had similar CSS, as did patients with pT3c and pT4 tumors. Moreover, both pT3a and pT3b stages included patients with heterogeneous outcomes. In multivariable analysis, the novel classification of the primary tumor was a powerful independent predictor of CSS (p for trend

Published
2011

205. Chromophobe renal cell carcinoma (RCC): oncological outcomes and prognostic factors in a large multicentre series

Author

Volpe, A., Novara, G., Antonelli, A., Bertini, R., Billia, M., Carmignani, G., Cosciani Cunico, S., Longo, N., Martignoni, G., Minervini, A., Mirone, V., Simonato, A., Terrone, C., Zattoni, F., Ficarra, V., De Cobelli, O., Martorana, G., Schiavina, R., Corti, S., Simeone, C., Castelli, M., Cimino, Sebastiano, Favilla, V., Morgia, Giuseppe Maria, Imbimbo, C., Carini, M., Masieri, L., Serni, S., Oneto, F., Varca, V., Rocco, F., Valotto, C., Costantini, E., Porena, M., Zucchi, A., Ciciliato, S., Lampropoulou, N., Siracusano, S., Fontana, D., Gontero, P., Tizzani, A., Artibani, W., Brunelli, M., Montorsi, F., Petralia, G., Roscigno, M., Strada, E., Alessandro Volpe, Giacomo Novara, Alessandro Antonelli, Roberto Bertini, Michele Billia, Giorgio Carmignani, Sergio Cosciani Cunico, Nicola Longo, Guido Martignoni, Andrea Minervini, Vincenzo Mirone, Alchiede Simonato, Carlo Terrone, Filiberto Zattoni, Vincenzo Ficarra, members of the Surveillance and Treatment Update on Renal Neoplasms (SATURN) Project – Leading Urological No-Profit Foundation for Advanced Research (LUNA) Foundation [.., Riccardo Schiavina, ], Volpe, A., Novara, G., Antonelli, A., Bertini, R., Billia, M., Carmignani, G., Cosciani Cunico, S., Longo, N., Martignoni, G., Minervini, A., Mirone, V., Simonato, A., Terrone, C., Zattoni, F., Ficarra, V., De Cobelli, O., Martorana, G., Schiavina, R., Corti, S., Simeone, C., Castelli, M., Cimino, S., Favilla, V., Morgia, G., Imbimbo, C., Carini, M., Masieri, L., Serni, S., Oneto, F., Varca, V., Rocco, F., Valotto, C., Costantini, E., Porena, M., Zucchi, A., Ciciliato, Stefano, Lampropoulou, N., Siracusano, Salvatore, Fontana, D., Gontero, P., Tizzani, A., Artibani, W., Brunelli, M., Montorsi, F., Petralia, G., Roscigno, M., Strada, E., Volpe, Alessandro, Novara, Giacomo, Antonelli, Alessandro, Bertini, Roberto, Billia, Michele, Carmignani, Giorgio, Cunico, Sergio Cosciani, Longo, Nicola, Martignoni, Guido, Minervini, Andrea, Mirone, Vincenzo, Simonato, Alchiede, Terrone, Carlo, Zattoni, Filiberto, Ficarra, Vincenzo, Volpe, A, Novara, G, Antonelli, A, Bertini, R, Billia, M, Carmignani, G, Cunico, Sc, Martignoni, G, Minervini, A, Simonato, A, Terrone, C, Zattoni, F, Imbimbo, Ciro, Ciciliato, S., and Siracusano, S.

Subjects
Male, renal cell carcinoma, chromophobe RCC, prognostic factors, Carcinoma, Nephrectomy, Prognosis, Renal cell, Kaplan-Meier Estimate, Chromophobe renal cell carcinoma, Chromophobe, Humans, Carcinoma, Renal Cell, carcinoma, renal cell, chromophobe, prognosis, nephrectomy, Kidney Neoplasm, Middle Aged, Kidney Neoplasms, oncological outcames, oncological outcomes and prognostic factors, Female, prognosi, Human
Abstract

Study Type - Outcomes (cohort) Level of Evidence 2b What's known on the subject? and What does the study add? About 80% of RCCs have clear cell histology, and consistent data are available about the clinical and histological characteristics of this histological subtype. Conversely, less attention has been dedicated to the study of non-clear cell renal tumours Specifically, published data show that chromophobe RCC (ChRCC) have often favourable pathological stages and better nuclear grades as well as a lower risk of metastasizing compared with clear cell RCC (ccRCC). Patients with ChRCC were shown to have significantly higher cancer-specific survival (CSS) probabilities compared with ccRCC. However, an independent prognostic role of RCC histotype was not confirmed in some large multicenter series and only a few studies have focused on the oncological outcomes of ChRCC. The present study is one of the few to evaluate cancer-related outcomes of ChRCC and represents to our knowledge the largest series of ChRCCs. Consequently, the present findings may assist in elucidating the natural history of surgically treated ChRCC. The present study confirms that ChRCCs have good prognosis and a low tendency to progress and metastasize. Only 1.3% of patients presented with distant metastases at diagnosis, and the 5- and 10-year CSS were 93% and 88.9%, respectively. However, although ChRCCs are generally characterised by an excellent prognosis, we observed that patients with locally advanced or metastatic cancers as well as those with sarcomatoid differentiation have a poor outcome. The study also investigated prognostic factors for recurrence-free survival (RFS) and CSS for this RCC histotype. The definition of outcome predictors can be useful for patient counselling, planning of follow-up strategies, and patient selection for clinical trials. In the present study, gender, clinical T stage, pathological T stage, and presence of sarcomatoid differentiation were significantly associated with RFS and CSS at multivariable analysis. We also identified N/M stage as an independent predictor of CSS. Notably, as Fuhrman grade was not an independent predictor of cancer-related outcomes, the present study confirms that this histological variable is not a reliable prognostic factor for ChRCC. OBJECTIVES: To investigate cancer-related outcomes of chromophobe renal cell carcinoma (ChRCC) in a large multicentre dataset. To determine prognostic factors for recurrence-free survival (RFS) and cancer-specific survival (CSS) for this RCC histological type. PATIENTS AND METHODS: In all, 291 patients with ChRCC were identified from a multi-institutional retrospective database including 5463 patients who were surgically treated for RCC at 16 Italian academic centres between 1995 and 2007. Univariable and multivariable Cox regression models were used to identify prognostic factors predictive of RFS and CSS after surgery for ChRCC. RESULTS: At a median follow-up of 44 months, 25 patients (8.6%) had disease recurrence and 18 patients (6.2%) died from disease. The 5-year RFS and CSS rates were 89.3% and 93%, respectively. Gender (P= 0.014), clinical T stage (P= 0.017), pathological T stage (P= 0.003), and sarcomatoid differentiation (P= 0.032) were independent predictors of RFS at multivariable analysis. For CSS, there was an independent prognostic role for gender (P= 0.032) and T stage (P= 0.019) among the clinical variables and for T stage (P= 0.016), N/M stage (P= 0.023), and sarcomatoid differentiation (P= 0.015) among the pathological variables. CONCLUSIONS: Patients with ChRCC have a low risk of tumour progression, metastasis, and cancer-specific death. Patient gender, clinical and pathological tumour stage, and sarcomatoid differentiation are significant predictors of RFS and CSS for ChRCC.

Published
2011

206. Simple enucleation is equivalent to traditional partial nephrectomy for renal cell carcinoma: results of a nonrandomized, retrospective, comparative study

Author

Minervini, A, Ficarra, Vincenzo, Rocco, F, Antonelli, A, Bertini, R, Carmignani, G, Cosciani Cunico, S, Fontana, D, Longo, N, Martorana, G, Mirone, V, Morgia, G, Novara, Giacomo, Roscigno, M, Schiavina, R, Serni, S, Simeone, C, Simonato, A, Siracusano, S, Volpe, A, Zattoni, Filiberto, Zucchi, A, Carini, M, SATURN Project LUNA Foundation, Minervini, A, Ficarra, V, Rocco, F, Antonelli, A, Bertini, R, Carmignani, G, Cosciani Cunico, S, Fontana, D, Longo, Nicola, Martorana, G, Mirone, Vincenzo, Morgia, G, Novara, G, Roscigno, M, Schiavina, R, Serni, S, Simeone, C, Simonato, A, Siracusano, S, Volpe, A, Zattoni, F, Zucchi, A, Carini, M., Minervini A, Ficarra V, Rocco F, Antonelli A, Bertini R, Carmignani G, Cosciani Cunico S, Fontana D, Longo N, Martorana G, Mirone V, Morgia G, Novara G, Roscigno M, Schiavina R, Serni S, Simeone C, Simonato A, Siracusano S, Volpe A, Zattoni F, Zucchi A, Carini M, MINERVINI A, FICARRA V, ROCCO F, ANTONELLI A, BERTINI R, CARMIGNANI G, COSCIANI CUNICO S, FONTANA D, LONGO N, MARTORANA G, MIRONE V, MORGIA G, NOVARA G, ROSCIGNO M, SCHIAVINA R., SERNI S, SIMEONE C, SIMONATO A, SIRACUSANO S, VOLPE A, ZATTONI F, ZUCCHI A, CARINI M, A., Minervini, V., Ficarra, F., Rocco, A., Antonelli, R., Bertini, G., Carmignani, S. C., Cunico, D., Fontana, N., Longo, G., Martorana, V., Mirone, G., Morgia, G., Novara, M., Roscigno, R., Schiavina, S., Serni, C., Simeone, A., Simonato, Siracusano, Salvatore, A., Volpe, F., Zattoni, A., Zucchi, M., Carini, Carini, M, Members of the SATURN Project–LUNA, F. o. u. n. d. a. t. i. o. n., Andrea, Minervini, Vincenzo, Ficarra, Francesco, Rocco, Alessandro, Antonelli, Roberto, Bertini, Giorgio, Carmignani, Imbimbo, Ciro, Sergio Cosciani, Cunico, Dario, Fontana, Giuseppe, Martorana, Giuseppe, Morgia, Giacomo, Novara, Marco, Roscigno, Riccardo, Schiavina, Sergio, Serni, Claudio, Simeone, Alchiede, Simonato, Salvatore, Siracusano, Alessandro, Volpe, Filiberto, Zattoni, Alessandro, Zucchi, and Marco, Carini

Subjects
Carcinoma, Renal Cell, pathology/surgery, Chi-Square Distribution, Disease-Free Survival, Female, Humans, Kidney Neoplasms, pathology/surgery, Male, Middle Aged, Neoplasm Staging, Nephrectomy, methods, Nephrons, pathology/surgery, Proportional Hazards Models, Retrospective Studies, Statistics, Nonparametric, Treatment Outcome, Male, medicine.medical_treatment, carcinoma, lcsh:RC870-923, renal cell carcinoma, partial nephrectomy, Renal cell carcinoma, nephrectomy, renal cell, comparative study, Statistics, kidney cancer, Middle Aged, Nephrectomy, Kidney Neoplasms, Simple enucleation, Treatment Outcome, Female, Traditional Partial Nephrectomy, enucleation, medicine.medical_specialty, Urology, Enucleation, retrospective, Disease-Free Survival, methods, renal tumor, margin of healthy parenchyma, medicine, Humans, Nonparametric, Progression-free survival, Neoplasm Staging, Proportional Hazards Models, Retrospective Studies, pathology/surgery, Chi-Square Distribution, Performance status, business.industry, Simple enucleation is equivalent to traditional partial nephrectomy for renal cell carcinoma: results of a nonrandomized, Retrospective cohort study, Nephrons, medicine.disease, lcsh:Diseases of the genitourinary system. Urology, Surgery, Log-rank test, business
Abstract

Purpose: The excision of the renal tumor with a substantial margin of healthy parenchyma is considered the gold standard technique for partial nephrectomy. However, simple enucleation showed excellent results in some retrospective series. We compared the oncologic outcomes after standard partial nephrectomy and simple enucleation. Materials and Methods: We retrospectively analyzed 982 patients who underwent standard partial nephrectomy and 537 who had simple enucleation for localized renal cell carcinoma at 16 academic centers between 1997 and 2007. Local recurrence, cancer specific survival and progression-free survival were the main outcomes of this study. The Kaplan-Meier method was used to calculate survival functions and differences were assessed with the log rank statistic. Univariable and multivariable Cox regression models addressed progression-free survival and cancer specific survival. Results: Median followup of the patients undergoing traditional partial nephrectomy and simple enucleation was 51 +/- 37.8 and 54.4 +/- 36 months, respectively (p = 0.08). The 5 and 10-year progression-free survival estimates were 88.9 and 82% after standard partial nephrectomy, and 91.4% and 90.8% after simple enucleation (p = 0.09). The 5 and 10-year cancer specific survival estimates were 93.9% and 91.6% after standard partial nephrectomy, and 94.3% and 93.2% after simple enucleation (p = 0.94). On multivariable analysis the adopted nephron sparing surgery technique was not an independent predictor of progression-free survival (HR 0.8, p = 0.55) and cancer specific survival (HR 0.7, p = 0.53) when adjusted for the effect of the other covariates. Conclusions: To our knowledge this is the first multicenter, comparative study showing oncologic equivalence of standard partial nephrectomy and simple enucleation.

Published
2011

207. Search for Baryonium by High Resolution Measurement of p̄p Elastic Differential Cross Section and Analysing Power from 250 MeV/c to 700 MeV/c

Author

Bertini, R., Birien, P., Bruge, G., Catz, H., Chaumeaux, A., Durand, J. M., Mayer, B., Bedjian, H., Descroix, E., Guichard, A., Gusakow, M., Grossiord, J. Y., Haroutunian, R., Pizzi, J. R., Arvieux, J., Boschitz, E. T., Mathie, A. L., Smith, G. R., Mayer, M., Vogler, F., Konter, J. A., Mango, S., Yavin, A., Zichichi, Antonino, editor, Gastaldi, Ugo, editor, and Klapisch, Robert, editor

Published
1984
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212. Extent of lymph node dissection at nephrectomy affects cancer-specific survival and metastatic progression in specific sub-categories of patients with renal cell carcinoma (RCC)

Author

Capitanio U, Suardi N, Matloob R, Roscigno M, Abdollah F, Di Trapani E, Moschini M, Gallina A, SALONIA , ANDREA, Briganti A, MONTORSI , FRANCESCO, Bertini R., Capitanio, U, Suardi, N, Matloob, R, Roscigno, M, Abdollah, F, Di Trapani, E, Moschini, M, Gallina, A, Salonia, Andrea, Briganti, A, Montorsi, Francesco, and Bertini, R.

Subjects
Adult, Male, renal cell carcinoma, Adolescent, Urology, lymph node dissection, lymph node invasion, survival, Nephrectomy, Disease-Free Survival, Young Adult, cancer-specific survival, Carcinoma, Renal Cell, Aged, Neoplasm Staging, Aged, 80 and over, Neoplasm Invasivene, kidney cancer, metastases progression-free survival, Kidney Neoplasm, Middle Aged, Survival Rate, metastase, lymphadenectomy, Lymph Node Excision, Female, Cohort Studie, Human
Abstract

Objective To test whether the number of lymph nodes removed affects cancer-specific survival (CSS) or metastatic progression-free survival (MPFS) in different renal cell carcinoma (RCC) scenarios. Methods We used Cox regression analyses to analyse the effect of the number of lymph nodes removed on CSS and MPFS in 1983 patients with RCC treated with nephrectomy. To adjust for possible clinical and surgical selection bias, analyses were further adjusted for number of positive nodes, presence of metastases, age, performance status, T stage, tumour size and grade. Results The prevalence of lymph node invasion was 6.1%. The mean follow-up period was 83.3 months. Multivariable analyses showed that the number of nodes removed had an independent, protective effect on CSS in patients with pT2a-pT2b or pT3c-pT4 RCC (hazard ratio [HR] 0.91, P = 0.008 and HR 0.89, P < 0.001, respectively), in patients with bulky tumours (tumour size >10 cm, HR 0.97, P = 0.03) or when sarcomatoid features were found (HR 0.81, P = 0.006). The removal of each additional lymph node was associated with a 3-19% increase in CSS. When considering MPFS as an endpoint, the number of nodes removed had an independent, protective effect in the same patient categories. Conclusions When clinically indicated, the number of nodes removed affects CSS and MPFS in specific sub-categories of patients with RCC. © 2013 The Authors. BJU International © 2013 BJU International.

Published
2014

213. Transverse target spin asymmetries in exclusive $ ho^0$ muoproduction

Author

Adolph, C., Alekseev, M. G., Alexakhin, V. Y. u., Alexandrov, Y. u., Alexeev, G. D., Amoroso, A., Andrieux, V., Austregesilo, A., Badellek, B., Balestra, F., Barth, J., Baum, G., Bedfer, Y., Berlin, A., Bernhard, J., Bertini, R., Bicker, K., Bieling, J., Birsa, R., Bisplinghoff, J., Boer, M., Bordalo, P., Bradamante, Franco, Braun, C., Bravar, A., Bressan, Andrea, Buechele, M., Burtin, E., Capozza, L., Chiosso, M., Chung, S. U., Cicuttin, A., Crespo, M. L., Dalla Torre, S., Dasgupta, S. S., Dasgupta, S., Denisov, O. Y. u., Donskov, S. V., Doshita, N., Duic, Venicio, Duennweber, W., Dziewiecki, M., Efremov, A., Elia, Carmine, Eversheim, P. D., Eyrich, W., Faessler, M., Ferrero, A., Filin, A., Finger, M., Finger~jr, M., Fischer, H., Franco, C., Du~fresne~von~hohenesche, N., Friedrich, J. M., Frolov, V., Garfagnini, R., Gautheron, F., Gavrichtchouk, O. P., Gerassimov, S., Geyer, R., Giorgi, Marcello, Gnesi, I., Gobbo, B., Goertz, S., Grabmueller, S., Grasso, A., Grube, B., Gushterski, R., Guskov, A., Guthoerl, T., Haas, F., von Harrach, D., Hahne, D., Heinsius, F. H., Herrmann, F., Hess, C., Hinterberger, F., Hoeppner, C. h., Horikawa, N., D'Hose, N., Huber, S., Ishimoto, S., Ivanshin, Y. u., Iwata, T., Jahn, R., Jary, V., Jasinski, P., Joosten, R., Kabuss, E., Kang, D., Ketzer, B., Khaustov, G. V., Khokhlov, Y. u. A., Kisselev, Y. u., Klein, F., Klimaszewski, K., Koivuniemi, J. H., Kolosov, V. N., Kondo, K., Koenigsmann, K., Konorov, I., Konstantinov, V. F., Kotzinian, A. M., Kouznetsov, O., Kraemer, M., Kroumchtein, Z. V., Kuchinski, N., Kunne, F., Kurek, K., Kurjata, R. P., Lednev, A. A., Lehmann, A., Levorato, Stefano, Lichtenstadt, J., Maggiora, A., Magnon, A., Makke, Nour, Mallot, G. K., Marchand, C., Martin, Anna, Marzec, J., Matousek, Jan, Matsuda, H., Matsuda, T., Meshcheryakov, G., Meyer, W., Michigami, T., Mikhailov, Y. u. V., Miyachi, Y., Morreale, A., Nagaytsev, A., Nagel, T., Nerling, F., Neubert, S., Neyret, D., Nikolaenko, V. I., Novy, J., Nowak, W. D., Nunes, A. S., Olshevsky, A. G., Ostrick, M., Panknin, R., Panzieri, D., Parsamyan, B., Paul, S., Pesek, M., Piragino, G., Platchkov, S., Pochodzalla, J., Polak, J., Polyakov, V. A., Pretz, J., Quaresma, M., Quintans, C., Ramos, S., Reicherz, G., Rocco, Elena, Rodionov, V., Rondio, E., Rossiyskaya, N. S., Ryabchikov, D. I., Samoylenko, V. D., Sandacz, A., Sapozhnikov, M. G., Sarkar, S., Savin, I. A., Sbrizzai, Giulio, Schiavon, Paolo, Schill, C., Schlueter, T., Schmidt, A., Schmidt, K., Schmitt, L., Schmieden, H., Schoenning, K., Schopferer, S., Schott, M., Shevchenko, O. Y. u., Silva, L., Sinha, L., Sirtl, S., Slunecka, M., Sosio, S., Sozzi, Federica, Srnka, A., Steiger, L., Stolarski, M., Sulc, M., Sulej, R., Suzuki, H., Sznajder, P., Takekawa, S., Ter~wolbeek, J., Tessaro, Susanna, Tessarotto, F., Thibaud, F., Uhl, S., Uman, I., Vandenbroucke, M., Virius, M., Vondra, J., Wang, L., Weisrock, T., Wilfert, M., Windmolders, R., Wislicki, W., Wollny, H., Zaremba, K., Zavertyaev, M., Zemlyanichkina, E., Zhuravlev, N., Ziembicki, M., Adolph, C., Alekseev, M. G., Alexakhin, V. Y. u., Alexandrov, Y. u., Alexeev, G. D., Amoroso, A., Andrieux, V., Austregesilo, A., Badellek, B., Balestra, F., Barth, J., Baum, G., Bedfer, Y., Berlin, A., Bernhard, J., Bertini, R., Bicker, K., Bieling, J., Birsa, R., Bisplinghoff, J., Boer, M., Bordalo, P., Bradamante, Franco, Braun, C., Bravar, A., Bressan, Andrea, Buechele, M., Burtin, E., Capozza, L., Chiosso, M., Chung, S. U., Cicuttin, A., Crespo, M. L., Dalla Torre, S., Dasgupta, S. S., Dasgupta, S., Denisov, O. Y. u., Donskov, S. V., Doshita, N., Duic, Venicio, Duennweber, W., Dziewiecki, M., Efremov, A., Elia, Carmine, Eversheim, P. D., Eyrich, W., Faessler, M., Ferrero, A., Filin, A., Finger, M., Finger~jr, M., Fischer, H., Franco, C., Du~fresne~von~hohenesche, N., Friedrich, J. M., Frolov, V., Garfagnini, R., Gautheron, F., Gavrichtchouk, O. P., Gerassimov, S., Geyer, R., Giorgi, Marcello, Gnesi, I., Gobbo, B., Goertz, S., Grabmueller, S., Grasso, A., Grube, B., Gushterski, R., Guskov, A., Guthoerl, T., Haas, F., von Harrach, D., Hahne, D., Heinsius, F. H., Herrmann, F., Hess, C., Hinterberger, F., Hoeppner, C. h., Horikawa, N., D'Hose, N., Huber, S., Ishimoto, S., Ivanshin, Y. u., Iwata, T., Jahn, R., Jary, V., Jasinski, P., Joosten, R., Kabuss, E., Kang, D., Ketzer, B., Khaustov, G. V., Khokhlov, Y. u. A., Kisselev, Y. u., Klein, F., Klimaszewski, K., Koivuniemi, J. H., Kolosov, V. N., Kondo, K., Koenigsmann, K., Konorov, I., Konstantinov, V. F., Kotzinian, A. M., Kouznetsov, O., Kraemer, M., Kroumchtein, Z. V., Kuchinski, N., Kunne, F., Kurek, K., Kurjata, R. P., Lednev, A. A., Lehmann, A., Levorato, Stefano, Lichtenstadt, J., Maggiora, A., Magnon, A., Makke, Nour, Mallot, G. K., Marchand, C., Martin, Anna, Marzec, J., Matousek, Jan, Matsuda, H., Matsuda, T., Meshcheryakov, G., Meyer, W., Michigami, T., Mikhailov, Y. u. V., Miyachi, Y., Morreale, A., Nagaytsev, A., Nagel, T., Nerling, F., Neubert, S., Neyret, D., Nikolaenko, V. I., Novy, J., Nowak, W. D., Nunes, A. S., Olshevsky, A. G., Ostrick, M., Panknin, R., Panzieri, D., Parsamyan, B., Paul, S., Pesek, M., Piragino, G., Platchkov, S., Pochodzalla, J., Polak, J., Polyakov, V. A., Pretz, J., Quaresma, M., Quintans, C., Ramos, S., Reicherz, G., Rocco, Elena, Rodionov, V., Rondio, E., Rossiyskaya, N. S., Ryabchikov, D. I., Samoylenko, V. D., Sandacz, A., Sapozhnikov, M. G., Sarkar, S., Savin, I. A., Sbrizzai, Giulio, Schiavon, Paolo, Schill, C., Schlueter, T., Schmidt, A., Schmidt, K., Schmitt, L., Schmieden, H., Schoenning, K., Schopferer, S., Schott, M., Shevchenko, O. Y. u., Silva, L., Sinha, L., Sirtl, S., Slunecka, M., Sosio, S., Sozzi, Federica, Srnka, A., Steiger, L., Stolarski, M., Sulc, M., Sulej, R., Suzuki, H., Sznajder, P., Takekawa, S., Ter~wolbeek, J., Tessaro, Susanna, Tessarotto, F., Thibaud, F., Uhl, S., Uman, I., Vandenbroucke, M., Virius, M., Vondra, J., Wang, L., Weisrock, T., Wilfert, M., Windmolders, R., Wislicki, W., Wollny, H., Zaremba, K., Zavertyaev, M., Zemlyanichkina, E., Zhuravlev, N., and Ziembicki, M.

Subjects
polarization, gpd, exclusive reactions, hemp
Abstract

Exclusive production of ρ0ρ0 mesons was studied at the COMPASS experiment by scattering 160 GeV/c160 GeV/c muons off transversely polarised protons. Five single-spin and three double-spin azimuthal asymmetries were measured as a function of Q2Q2, xBjxBj, or View the MathML sourcepT2. The View the MathML sourcesinϕS asymmetry is found to be −0.019±0.008(stat.)±0.003(syst.)−0.019±0.008(stat.)±0.003(syst.). All other asymmetries are also found to be of small magnitude and consistent with zero within experimental uncertainties. Very recent calculations using a GPD-based model agree well with the present results. The data is interpreted as evidence for the existence of chiral-odd, transverse generalized parton distributions.

Published
2014

214. Transverse target spin asymmetries in exclusive <math altimg='si1.gif' xmlns='http://www.w3.org/1998/Math/MathML'><msup><mrow><mi>ρ</mi></mrow><mrow><mn>0</mn></mrow></msup></math> muoproduction

Author

Guthoerl, T., Paul, S., T. Nagel, A.M. Kotzinian, S. Gerassimov, Hohenesche, N. du Fresne von, Olshevsky, A.G.(Joint Institute for Nuclear Research, Moscow Region, Dubna, 141980, Russia), Quintans, C., Silva, L., Finger, M, Elia, C., Bedfer, Y., B. Grube, Quaresma, M., Balestra, F., F. Gautheron, Austregesilo, A., Badellek, B., Wang, L., Kabuss, E., Doshita, N., Matsuda, H.(Yamagata University, Yamagata, 992-8510, Japan), Sirtl, S., Kunne, F., Schlueter, T., Koivuniemi, J. H., S. Takekawa, V.A. Polyakov, Ziembicki, M., Berlin, A., Garfagnini, R.(University of Turin, Department of Physics, Turin, 10125, Italy), Huber, S., Nunes, A.S.(LIP, Lisbon, 1000-149, Portugal), Lednev, A. A., Dasgupta, S., Gavrichtchouk, O. P., Levorato, S.(Trieste Section of INFN, Trieste, 34127, Italy), Kurek, K., Ishimoto, S., Chung, S U., Thibaud, F.(CEA IRFU/SPhN Saclay, Gif-sur-Yvette, 91191, France), Mikhailov, Yu.V.(State Research Center of the Russian Federation, Institute for High Energy Physics, Protvino, 142281, Russia), V. Andrieux, M. Faessler, Crespo, M.L.(Abdus Salam ICTP, Trieste, 34151, Italy), Capozza, L., Guskov, A., Kouznetsov, O., Ramos, S., Platchkov, S.(CEA IRFU/SPhN Saclay, Gif-sur-Yvette, 91191, France), Shevchenko, O. Yu., Dziewiecki, M., Matsuda, T, V.N. Kolosov, K. Klimaszewski, Eyrich, W., Rodionov, V., E. Zemlyanichkina, Ostrick, M., Khokhlov, Yu. A., N.S. Rossiyskaya, Haas, F., Cicuttin, A., P. Jasinski, Efremov, A.(Joint Institute for Nuclear Research, 141980, Moscow region, Dubna, Russia), Ketzer, B., Sozzi, F., Friedrich, J.M., Schmidt, K, J. Bieling, Meyer, W, Filin, A., Kroumchtein, Z. V., Martin, A., Lichtenstadt, J., Ferrero, A., Khaustov, G. V., Fischer, H., Buechele, M., I.A. Savin, Grasso, A., Bressan, A., Slunecka, M., Srnka, A., J. Matousek, Rocco, E., S. Neubert, Sarkar, S., Konstantinov, V. F., Bertini, R., Makke, N., E. Burtin, Schmieden, H., Sandacz, A., Adolph, C., Hinterberger, F., Goertz, S., Vondra, J., Franco, C, A. Amoroso, Alexakhin, V. Yu., F. Nerling, Kisselev, Yu.(Joint Institute for Nuclear Research, Dubna, Moscow Region, 141980, Russia), T. Iwata, Sapozhnikov, M. G., Gnesi, I., Miyachi, Y., Alexandrov, Yu., Duennweber, W., Rondio, E., Kondo, K., Nowak, W.-D., Lehmann, A.(Universität Erlangen–Nürnberg, Physikalisches Institut, Erlangen, 91054, Germany), Kang, D., Frolov, V., Schiavon, P., M. Giorgi, Baum, Günter, Kurjata, R. P., Meshcheryakov, G., Donskov, S. V., Reicherz, G., Joosten, R., Parsamyan, B., Wilfert, M., Neyret, D., M. Vandenbroucke, Boer, M., V.I. Nikolaenko, Marchand, C., Dasgupta, S.S.(Matrivani Institute of Experimental Research & Education, Calcutta-700 030, India 12 12 Supported by SAIL (CSR), Govt. of India.), Michigami, T., Ryabchikov, D.I., Pretz, J., S. Sosio, Suzuki, H, Kraemer, M., M.G. Alekseev, Eversheim, P. D., jr, M. Finger, Hoeppner, Ch., Schott, M, Gushterski, R., Hess, C, Zhuravlev, N., Maggiora, A., Panknin, R., Zaremba, K., Heinsius, F. H., S. Schopferer, Tessaro, S., Wollny, H., K. Schoenning(Uppsala University), Bisplinghoff, J., Sznajder, P., Steiger, L.(Trieste Section of INFN, 34127, Trieste, Italy), A. Morreale, Schmidt, A., Barth, J., Samoylenko, V. D., Konorov, I., Mallot, G. K., Marzec, J., Pesek, M.(Charles University in Prague, Faculty of Mathematics and Physics, Prague, 18000, Czech Republic), Torre, S. Dalla, Virius, M.(Czech Technical University in Prague, Prague, 16636, Czech Republic), P. Bordalo, Bradamante, F., Stolarski, M., Harrach, D. von, M. Sulc, Gobbo, B., Jary, V., Koenigsmann, K., Zavertyaev, M., W. Wislicki, Sinha, L., C. Schill, Panzieri, D.(University of Eastern Piedmont, Alessandria, 15100, Italy), Sulej, R., Grabmueller, S., Jahn, R.(Universität Bonn, Helmholtz-Institut für Strahlen- und Kernphysik, Bonn, 53115, Germany), Polak, J, Pochodzalla, J., Windmolders, R., Ivanshin, Yu., Birsa, R., Bicker, K., Magnon, A.(CEA IRFU/SPhN Saclay, 91191 Gif-sur-Yvette, France 17), Tessarotto, F., M. Chiosso, R. Geyer, Alexeev, G.D., Horikawa, N., d'Hose, N., Denisov, O.Yu., Klein, F.(Physikalisches Institut, Universität Bonn, Bonn, 53115, Germany), Braun, C., Piragino, G., Kuchinski, N., S. Uhl, G. Sbrizzai, Schmitt, L, Weisrock, T., F. Herrmann, Wolbeek, J. Ter, Novy, J, Bravar, A.(University of Geneva, Section de Physique, DPNC, Geneva, Switzerland), Nagaytsev, A., Uman, I.(Dogus University, Istanbul, 34722, Turkey), Duic, V., Hahne, D., and J. Bernhard

Subjects
Physik, Nuclear and High Energy Physics, ddc:530, Nuclear Experiment, Particle Physics - Experiment, High Energy Physics - Experiment
Abstract

Exclusive production of ρ0 mesons was studied at the COMPASS experiment by scattering 160 GeV/c muons off transversely polarised protons. Five single-spin and three double-spin azimuthal asymmetries were measured as a function of Q2 , xBj , or pT2 . The sinϕS asymmetry is found to be −0.019±0.008(stat.)±0.003(syst.) . All other asymmetries are also found to be of small magnitude and consistent with zero within experimental uncertainties. Very recent calculations using a GPD-based model agree well with the present results. The data is interpreted as evidence for the existence of chiral-odd, transverse generalized parton distributions.

Published
2016

215. Elective Nephron Sparing Surgery Decreases Other-Causes Mortality Relative to Radical Nephrectomy Only in Specific Subgroups of Patients with Renal Cell Carcinoma: Impact of Nephron Sparing Surgery on Non-Cancer Mortality

Author

Larcher, A, Capitanio, U, Terrone, C, Volpe, A, De Angelis, P, Deho, F, Fossati, N, Dell'Oglio, P, Antonelli, Alberto, Furlan, M, Simeone, C, Serni, Sergio, Carini, Marco, Minervini, Andrea, Fiori, C, Porpiglia, F, Briganti, A, Montorsi, F, and Bertini, R.

Subjects
Kidney, Carcinoma, Renal Cell, Nephrectomy, Cause of Death,Ccomorbidity
Published
2016

216. LA CHIRURGIA RENALE CONSERVATIVA RIDUCE LA MORTALITÀ NON TUMORE-SPECIFICA RISPETTO A NEFRECTOMIA RADICALE SOLAMENTE IN ALCUNI SOTTOGRUPPI DI PAZIENTI CON CARCINOMA RENALE

Author

Larcher, A., Muttin, F., Capitanio, U., Terrone, C., Volpe, A., De Angelis, P., Dehò, F., Fossati, N., Antonelli, A., Furlan, M., Dell’Oglio, P., Simeone, C., Serni, S., Carini, M., Minervini, A., Fiori, C., Porpiglia, F., Briganti, A., Montorsi, F., and Bertini, R.

Subjects
CHIRURGIA RENALE CONSERVATIVA, NEFRECTOMIA RADICALE, CARCINOMA RENALE
Published
2016

217. Nephron sparing surgery decreases other-causes mortality relative to radical nephrectomy only in specific subgroups of patients with renal cell carcinoma

Author

Larcher, A., Capitanio, U., Terrone, C., Dehò, F., Volpe, A., Antonelli, A., Minervini, Andrea, Fiori, C., Furlan, M., Serni, Sergio, Carini, Marco, Novara, G., Porpiglia, F., Simeone, C., Fossati, N., Briganti, A., Montorsi, F., and Bertini, R.

Subjects
Nephron sparing surgery, Radical nephrectomy, Renal cell carcinoma
Published
2016

219. SC269 - Ischemia time during partial nephrectomy has a different impact on renal function loss according to preoperative risk of acute kidney injury. Results from a prospective multicenter observational study (the RECORD2 project)

Author

Bravi, C., Capitanio, U., Mari, A., Larcher, A., Antonelli, A., Artibani, W., Barale, M., Bertini, R., Bove, P., Brunocilla, E., Da Pozzo, L., Di Maida, F., Tellini, R., Fiori, C., Gontero, P., Li Marzi, V., Longo, N., Mirone, V., Montanari, E., Porpiglia, F., Schiavina, R., Schips, L., Simeone, C., Siracusano, S., Terrone, C., Trombetta, C., Volpe, A., Montorsi, F., Ficarra, V., Carini, M., and Minervini, A.

Published
2019
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220. SC261 - Postoperative outcomes and two-year renal function in patients with limited life expectancy treated with partial nephrectomy for renal tumors: Analysis of predictors and comparison with patients with longer life expectancy (the record 2 project)

Author

Mari, A., Nazzani, S., Tellini, R., Gontero, P., Amparore, D., Antonelli, A., Barale, M., Bertini, R., Bove, P., Brunocilla, E., Capitanio, U., Da Pozzo, L., Mirone, V., Montanari, E., Porpiglia, F., Schiavina, R., Serni, S., Simeone, C., Trombetta, C., Volpe, A., Artibani, W., Ficarra, V., Carini, M., and Minervini, A.

Published
2019
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224. SC58 - Perioperative morbidity of open, laparoscopic and robotic partial nephrectomy: A prospective multicenter observational study (RECORd2)

Author

Bravi, C., Larcher, A., Capitanio, U., Montorsi, F., Antonelli, A., Barale, M., Bertini, R., Bove, P., Brunocilla, E., Da Pozzo, L., Di Maida, F., Gontero, P., Li Marzi, V., Longo, N., Montanari, E., Porpiglia, F., Schiavina, R., Simeone, C., Siracusano, S., Volpe, A., Ficarra, V., Carini, M., Mari, A., and Minervini, A.

Published
2019
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225. SC6 - A snapshot of nephron sparing surgery in Italy: A prospective, multicenter report on clinical and operative data (the RECORD 2 project)

Author

Mari, A., Di Maida, F., Brunocilla, E., Borghesi, M., Schiavina, R., Gontero, P., Pisano, F., Porpiglia, F., Fiori, C., Antonelli, A., Furlan, M., Mori, F., Bertini, R., Capitanio, U., Longo, N., Fusco, F., Da Pozzo, L., Serni, S., Montanari, E., Siracusano, S., Tellini, R., Porreca, A., Terrone, C., Mearini, E., Altieri, V., Ficarra, V., Carini, M., and Minervini, A.

Published
2019
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226. Comparison of robot-assisted and open surgery partial nephrectomy: an observational prospective study on functional and oncologic outcomes

Author

Larcher, A., primary, Capitanio, U., additional, Fossati, N., additional, De Naeyer, G., additional, De Groote, R., additional, Bianchi, L., additional, Turri, F.M., additional, Guazzoni, G., additional, Salonia, A., additional, Briganti, A., additional, Bertini, R., additional, Montorsi, F., additional, and Mottrie, A., additional

Published
2017
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227. Perioperative morbidity and complications after robot-assisted and open surgery partial nephrectomy: An observational prospective study

Author

Fossati, N., primary, Capitanio, U., additional, De Naeyer, G., additional, De Groote, R., additional, Bianchi, L., additional, Turri, F.M., additional, Guazzoni, G., additional, Salonia, A.R., additional, Briganti, A., additional, Bertini, R., additional, Montorsi, F., additional, and Mottrie, A., additional

Published
2017
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229. Proposal and validation of a dynamic criterion for patient inclusion in kidney cancer active surveillance protocols

Author

Larcher, A., primary, Muttin, F., additional, Ripa, F., additional, Stabile, A., additional, Trevisani, F., additional, Nini, A., additional, La Croce, G., additional, Carenzi, C., additional, Mottrie, A., additional, Salonia, A., additional, Briganti, A., additional, Montorsi, F., additional, Bertini, R., additional, and Capitanio, U., additional

Published
2017
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230. Does prostate cancer represent the main cause of death in all node positive prostate cancer patients? The impact of competing causes of mortality according to tumor characteristics and recurrence status

Author

Dell’Oglio, P., primary, Zaffuto, E., additional, Stabile, A., additional, Gandaglia, G., additional, Colicchia, M., additional, Fossati, N., additional, Capitanio, U., additional, Dehò, F., additional, Colombo, R., additional, Bertini, R., additional, Montorsi, F., additional, Karnes, J., additional, and Briganti, A., additional

Published
2017
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231. The ability of three comorbity indeces to predict postosperative mortality in renal cell carcinoma patients: The impending need of a new disease-specific index

Author

Dell’Oglio, P., primary, Larcher, A., additional, Muttin, F., additional, Fossati, N., additional, Nini, A., additional, Ripa, F., additional, La Croce, G., additional, Trevisani, F., additional, Carenzi, C., additional, Salonia, A., additional, Briganti, A., additional, Montorsi, F., additional, Bertini, R., additional, and Capitanio, U., additional

Published
2017
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232. Long-term assessment of mortality patterns after surgical treatment for non-metastatic kidney cancer: A competing risk analysis

Author

Larcher, A., primary, Muttin, F., additional, Nini, A., additional, Trevisani, F., additional, Ripa, F., additional, Cianflone, F., additional, Carenzi, C., additional, Dell'Oglio, P., additional, Rigatti, P., additional, Dehó, F., additional, Montorsi, F., additional, Capitanio, U., additional, and Bertini, R., additional

Published
2017
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233. The effect of anatomical location of retroperitoneal lymph node metastases on cancer specific survival in patients with clear cell renal cell carcinoma

Author

Nini, A., primary, Larcher, A., additional, Terrone, C., additional, Volpe, A., additional, Muttin, F., additional, Ripa, F., additional, Regis, F., additional, Lucianò, R., additional, Briganti, A., additional, Bertini, R., additional, Montorsi, F., additional, and Capitanio, U., additional

Published
2017
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234. Comparison of robot-assisted and open surgery partial nephrectomy: An observational prospective study on pathologic and early functional outcomes

Author

Larcher, A., primary, Capitanio, U., additional, Fossati, N., additional, De Naeyer, G., additional, De Groote, R., additional, Umari, P., additional, Trevisani, F., additional, Guazzoni, G., additional, Salonia, A., additional, Briganti, A., additional, Bertini, R., additional, Montorsi, F., additional, and Mottrie, A., additional

Published
2017
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235. Is a preoperative low ejection fraction a risk factor for complications and impaired survival in renal cancer patients who undergo surgery? Results from a propensity-score matching with non cardiopathic counterparts

Author

Nini, A., primary, Larcher, A., additional, Muttin, F., additional, Zaffuto, E., additional, Dell’Oglio, P., additional, Ripa, F., additional, Carenzi, C., additional, La Croce, G., additional, Oppizzi, M., additional, Fragasso, G., additional, Montorsi, F., additional, Capitanio, U., additional, and Bertini, R., additional

Published
2017
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236. Impact of intraoperative blood transfusions on survival after surgery for renal cell carcinoma

Author

La Croce, G., primary, Muttin, F., additional, Moschini, M., additional, Larcher, A., additional, Dell’Oglio, P., additional, Nini, A., additional, Ripa, F., additional, Cianflone, F., additional, Di Trapani, E., additional, Carenzi, C., additional, Dehò, F., additional, Montorsi, F., additional, Bertini, R., additional, and Capitanio, U., additional

Published
2017
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237. Predictive and prognostic effect of inflammatory lymphadenopathies in renal cell carcinoma

Author

Pecoraro, A., primary, Larcher, A., additional, Nini, A., additional, Muttin, F., additional, Stabile, A., additional, Di Trapani, E., additional, Carenzi, C., additional, Trevisani, F., additional, De Cobelli, F., additional, Gaboardi, F., additional, Guazzoni, G., additional, Briganti, A., additional, Montorsi, F., additional, Bertini, R., additional, and Capitanio, U., additional

Published
2017
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238. On-clamp versus off-clamp partial nephrectomy: Propensity score matched comparison of long term functional outcomes

Author

Simone, G., primary, Capitanio, U., additional, Larcher, A., additional, Ferriero, M., additional, Misuraca, L., additional, Tuderti, G., additional, Romeo, G., additional, Minisola, F., additional, Guaglianone, S., additional, Muttin, F., additional, Nini, A., additional, Trevisani, F., additional, Montorsi, F., additional, Bertini, R., additional, and Gallucci, M., additional

Published
2017
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239. First repeated biopsy represents the most informative predictor of progression-free survival at 3 years follow-up in patients included in an active surveillance protocol for low-risk prostate cancer

Author

Luzzago, S., primary, Suardi, N., additional, Dell’Oglio, P., additional, Fossati, N., additional, Capitanio, U., additional, Gandaglia, G., additional, Zaffuto, E., additional, Mirone, V., additional, Bertini, R., additional, Damiano, R., additional, Freschi, M., additional, Gaboardi, F., additional, Montorsi, F., additional, and Briganti, A., additional

Published
2017
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241. Spin asymmetry A1d and the spin-dependent structure function g1d of the deuteron at low values of x and Q2

Author

Alexakhin, V.Yu., Alexandrov, Yu., Alexeev, G.D., Amoroso, A., Badełek, B., Balestra, F., Ball, J., Baum, G., Bedfer, Y., Bernet, C., Bertini, R., Birsa, R., Bisplinghoff, J., Bordalo, P., Bradamante, F., Bravar, A., Bressan, A., Brona, G., Burtin, E., Bussa, M.P., Chapiro, A., Cicuttin, A., Colantoni, M., Costa, S., Crespo, M.L., d'Hose, N., Dalla Torre, S., Dasgupta, S.S., De Masi, R., Denisov, O.Yu., Dhara, L., Diaz Kavka, V., Dinkelbach, A.M., Donskov, S.V., Dorofeev, V.A., Doshita, N., Duic, V., Dünnweber, W., Eversheim, P.D., Eyrich, W., Fabro, M., Faessler, M., Falaleev, V., Ferrero, A., Ferrero, L., Finger, M., Finger Jr., M., Fischer, H., Franz, J., Friedrich, J.M., Frolov, V., Garfagnini, R., Gautheron, F., Gavrichtchouk, O.P., Gerassimov, S., Geyer, R., Giorgi, M., Gobbo, B., Goertz, S., Gorin, A.M., Grajek, O.A., Grasso, A., Grube, B., Hannappel, J., von Harrach, D., Hasegawa, T., Heckmann, J., Hedicke, S., Heinsius, F.H., Hermann, R., Heß, C., Hinterberger, F., von Hodenberg, M., Horikawa, N., Horikawa, S., Ilgner, C., Ioukaev, A.I., Ishimoto, S., Ivanov, O., Iwata, T., Jahn, R., Janata, A., Joosten, R., Jouravlev, N.I., Kabuß, E., Kang, D., Ketzer, B., Khaustov, G.V., Khokhlov, Yu.A., Khomutov, N.V., Kisselev, Yu., Klein, F., Koblitz, S., Koivuniemi, J.H., Kolosov, V.N., Komissarov, E.V., Kondo, K., Königsmann, K., Konorov, I., Konstantinov, V.F., Korentchenko, A.S., Korzenev, A., Kotzinian, A.M., Koutchinski, N.A., Kravchuk, N.P., Kroumchtein, Z.V., Kuhn, R., Kunne, F., Kurek, K., Ladygin, M.E., Lamanna, M., Le Goff, J.M., Lichtenstadt, J., Liska, T., Ludwig, I., Maggiora, A., Maggiora, M., Magnon, A., Mallot, G.K., Marchand, C., Marroncle, J., Martin, A., Marzec, J., Matsuda, T., Maximov, A.N., Meyer, W., Mielech, A., Mikhailov, Yu.V., Moinester, M.A., Nähle, O., Nassalski, J., Neliba, S., Neyret, D.P., Nikolaenko, V.I., Nozdrin, A.A., Obraztsov, V.F., Olshevsky, A.G., Ostrick, M., Padee, A., Pagano, P., Panebianco, S., Panzieri, D., Paul, S., Peshekhonov, D.V., Peshekhonov, V.D., Piragino, G., Platchkov, S., Pochodzalla, J., Polyakov, V.A., Popov, A.A., Pretz, J., Procureur, S., Quintans, C., Ramos, S., Reicherz, G., Rozhdestvensky, A.M., Rondio, E., Sadovski, A.B., Samoylenko, V.D., Sandacz, A., Sapozhnikov, M.G., Savin, I.A., Schiavon, P., Schill, C., Schmitt, L., Shevchenko, O.Yu., Shishkin, A.A., Siebert, H.-W., Sinha, L., Sissakian, A.N., Slunecka, M., Smirnov, G.I., Sozzi, F., Sugonyaev, V.P., Srnka, A., Stinzing, F., Stolarski, M., Sulc, M., Sulej, R., Takabayashi, N., Tchalishev, V.V., Tessarotto, F., Teufel, A., Tkatchev, L.G., Virius, M., Vlassov, N.V., Webb, R., Weise, E., Weitzel, Q., Windmolders, R., Wirth, S., Wiślicki, W., Zaremba, K., Zhao, J., Ziegler, R., and Zvyagin, A.

Subjects
Nuclear and High Energy Physics
Published
2007
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243. When to perform preoperative bone scan for kidney cancer staging

Author

Larcher, A., primary, Muttin, F., additional, Nini, A., additional, Dell’oglio, P., additional, Fossati, N., additional, Suardi, N., additional, Stabile, A., additional, Carenzi, C., additional, Trevisani, F., additional, Salonia, A., additional, Briganti, A., additional, Bertini, R., additional, Montorsi, F., additional, and Capitanio, U., additional

Published
2016
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244. Decreased transcriptional activity of Calcium-sensing receptor gene promoter 1 is associated with calcium nephrolithiasis

Author

Vezzoli G, Terranegra A, Aloia A, Arcidiacono T, Milanesi L, Mosca E, Mingione A, Spotti D, Cusi D, Hou J, Hendy GN, Soldati L, Paloschi V, Dogliotti E, Brasacchio C, Dell'Antonio G, Montorsi F, Bertini R, Bellinzoni P, Guazzoni G, Borghi L, Guerra A, Allegri F, Ticinesi A, Meschi T, Nouvenne A, Lupo A, Fabris A, Gambaro G, Rendina D, De Filippo G, Brandi ML, Croppi E, Cianferotti L, Trinchieri A, Caudarella R, Cupisti A, Anglani F, Del Prete D, GENIAL network, STRAZZULLO, PASQUALE, Vezzoli, G, Terranegra, A, Aloia, A, Arcidiacono, T, Milanesi, L, Mosca, E, Mingione, A, Spotti, D, Cusi, D, Hou, J, Hendy, Gn, Soldati, L, Paloschi, V, Dogliotti, E, Brasacchio, C, Dell'Antonio, G, Montorsi, F, Bertini, R, Bellinzoni, P, Guazzoni, G, Borghi, L, Guerra, A, Allegri, F, Ticinesi, A, Meschi, T, Nouvenne, A, Lupo, A, Fabris, A, Gambaro, G, Strazzullo, Pasquale, Rendina, D, De Filippo, G, Brandi, Ml, Croppi, E, Cianferotti, L, Trinchieri, A, Caudarella, R, Cupisti, A, Anglani, F, Del Prete, D, and Genial, Network

Subjects
Male, Transcription, Genetic, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Kidney, Biochemistry, Endocrinology, Receptors, Site-Directed, Settore MED/14 - NEFROLOGIA, Hypercalciuria, strontium, Promoter Regions, Genetic, transcription factor, messenger RNA, Single Nucleotide, Middle Aged, unclassified drug, Calcium-Sensing, Female, Calcium-sensing receptor, Transcription, Adult, medicine.medical_specialty, Calcium Nephrolithiasis, Genotype, chemistry.chemical_element, Single-nucleotide polymorphism, Calcium, Biology, Nephrolithiasis, Polymorphism, Single Nucleotide, Promoter Regions, Genetic, Internal medicine, medicine, claudin, CaSR, Humans, Endocrine Research, Polymorphism, Gene, Transcription factor, Alleles, Calcium sensing receptor, Biochemistry (medical), HEK 293 cells, Promoter, claudin 14, CaSR, Calcium Nephrolithiasis, kidney, medicine.disease, Molecular biology, HEK293 Cells, chemistry, Mutagenesis, Case-Control Studies, Mutagenesis, Site-Directed, Receptors, Calcium-Sensing
Abstract

BACKGROUND: CaSR gene is a candidate for calcium nephrolithiasis. Single-nucleotide polymorphisms (SNPs) encompassing its regulatory region were associated with calcium nephrolithiasis. AIMS: We tested SNPs in the CaSR gene regulatory region associated with calcium nephrolithiasis and their effects in kidney. SUBJECTS AND METHODS: One hundred sixty-seven idiopathic calcium stone formers and 214 healthy controls were genotyped for four CaSR gene SNPs identified by bioinformatics analysis as modifying transcription factor binding sites. Strontium excretion after an oral load was tested in 55 stone formers. Transcriptional activity induced by variant alleles at CaSR gene promoters was compared by luciferase reporter gene assay in HEK-293 and HKC-8 cells. CaSR and claudin-14 mRNA levels were measured by real-time PCR in 107 normal kidney medulla samples and compared in patients with different CaSR genotype. RESULTS: Only rs6776158 (A>G), located in the promoter 1, was associated with nephrolithiasis. Its minor G allele was more frequent in stone formers than controls (37.8% vs 26.4%, P = .001). A reduced strontium excretion was observed in GG homozygous stone formers. Luciferase fluorescent activity was lower in cells transfected with the promoter 1 including G allele at rs6776158 than cells transfected with the A allele. CaSR mRNA levels were lower in kidney medulla samples from homozygous carriers for the G allele at rs6776158 than carriers for the A allele. Claudin-14 mRNA levels were also lower in GG homozygous subjects. CONCLUSIONS: Minor allele at rs6776158 may predispose to calcium stones by decreasing transcriptional activity of the CaSR gene promoter 1 and CaSR expression in kidney tubules.

Published
2013

245. Staging lymphadenectomy in renal cell carcinoma must be extended: a sensitivity curve analysis

Author

Capitanio U, Suardi N, Matloob R, Abdollah F, Castiglione F, BRIGANTI , ALBERTO, Carenzi C, Roscigno M, MONTORSI , FRANCESCO, Bertini R., Capitanio, U, Suardi, N, Matloob, R, Abdollah, F, Castiglione, F, Briganti, Alberto, Carenzi, C, Roscigno, M, Montorsi, Francesco, and Bertini, R.

Abstract

Objective To investigate the staging of lymphadenectomy in renal cell carcinoma. No convincing data exist regarding the minimum number of lymph nodes that should be removed at the time of nephrectomy to ensure an accurate staging. Methods Between 1987 and 2011, 850 patients with renal cell carcinoma underwent either partial or radical nephrectomy plus lymph node dissection (LND) at a single tertiary care institution (T(any)N0-1M(any)). Receiver operating characteristic curve coordinates were used to graph the probability of finding lymph node invasion according to the number of removed lymph nodes. Assuming that the likelihood of finding lymph node invasion according to the number of lymph nodes removed may be affected by patient characteristics, analyses were further stratified for clinical and pathological characteristics. Results The rate of lymph node metastases strongly correlated with the clinical and pathological characteristics of the patients. Fifteen lymph nodes need to be removed to achieve a 90% probability of detecting at least one metastatic lymph node. Only slight differences were recorded after stratification for clinical nodal status, the presence of metastases at diagnosis and pathological T stage. Finally, 13, 16 and 21 lymph nodes need to be removed to achieve a 90% probability of detecting lymph node invasion, if present, in the low risk (score 0-1), intermediate risk (score 2-3) and high risk (score 4-5) Mayo Clinic classification, respectively.

Published
2013

246. Effect of number and location of distant metastases on renal cell carcinoma mortality in candidates for cytoreductive nephrectomy: Implications for multimodal therapy

Author

Capitanio, U, Abdollah, F, Matloob, R, Salonia, A, Suardi, N, Briganti, A, Carenzi, C, Rigatti, P, Montorsi, F, Bertini, R, Capitanio, U, Abdollah, F, Matloob, R, Salonia, Andrea, Suardi, N, Briganti, Alberto, Carenzi, C, Rigatti, P, Montorsi, Francesco, and Bertini, R.

Subjects
Cancer-specific survival, Urology, Metastase, Kidney Neoplasm, Cytoreductive surgery, Nephrectomy, Carcinoma, Renal Cell, Renal cell carcinoma, Human
Abstract

Objective To test whether the combination of number and location of distant metastases affects cancer-specific survival in patients with metastatic renal cell carcinoma. Methods Overall, 242 metastatic renal cell carcinoma patients with synchronous metastases at diagnosis underwent cytoreductive nephrectomy at a single institution. Combinations of number and location of distant metastases were coded as: single metastasis and single organ affected, multiple metastases and single organ affected, single metastasis for each of the multiple organs affected, and multiple metastases for each of the multiple organs affected. Covariates included age, symptoms, performance status, American Society of Anesthesiologists score, hemoglobin, lactate dehydrogenase, tumor size, Fuhrman grade, T stage, lymph node status, necrosis, sarcomatoid features and metastasectomy at the time of nephrectomy. Results The median survival was 34.7 versus 32.3 versus 29.6 versus 8.5months for single metastasis and single organ affected, multiple metastases and single organ affected single metastasis for each of the multiple organs affected, and multiple metastases for each of the multiple organs affected patients, respectively. At multivariable analyses, the combination of number and location of distant metastases resulted in one of the most informative and independent predictors of cancer-specific survival in metastatic renal cell carcinoma patients. The lung was the location with the highest rate of single organ affected (50.3% vs 35.1% in other sites; P

Published
2013

247. When to perform lymph node dissection in patients with renal cell carcinoma: a novel approach to the preoperative assessment of risk of lymph node invasion at surgery and of lymph node progression during follow-up

Author

Capitanio U, Abdollah F, Matloob R, Suardi N, Castiglione F, Di Trapani E, Capogrosso P, Gallina A, Dell'Oglio P, BRIGANTI , ALBERTO, SALONIA , ANDREA, MONTORSI , FRANCESCO, Bertini R., Capitanio, U, Abdollah, F, Matloob, R, Suardi, N, Castiglione, F, Di Trapani, E, Capogrosso, P, Gallina, A, Dell'Oglio, P, Briganti, Alberto, Salonia, Andrea, Montorsi, Francesco, and Bertini, R.

Subjects
Neoplasm Invasivene, renal cell carcinoma, lymph node progression, Urology, Kidney Neoplasm, lymph node dissection, Lymphatic Metastasi, lymph node invasion, Middle Aged, RCC, Risk Assessment, Follow-Up Studie, nomogram, Retrospective Studie, lymphadenectomy, Preoperative Care, Disease Progression, Lymph Node Excision, Carcinoma, Renal Cell, Human
Abstract

Objective To identify preoperatively patients who might benefit from lymph node dissection (LND). Patients and Methods We assessed lymph node invasion (LNI) at final pathology and lymph node (LN) progression during the follow-up for 1983 patients with RCC, treated with either partial or radical nephrectomy. LN progression was defined as the onset of a new clinically detected lymphadenopathy (>10mm) in the retroperitoneal lymphatic area. Logistic regression analyses were used to assess the effect of each potential clinical predictor (age, body mass index, tumour side, symptoms, performance status, clinical tumour size, clinical tumour-node-metastasis stage, and albumin, calcium, creatinine, haemoglobin and platelet levels) on the outcome of interest. The most parsimonious multivariable predictive model was developed, and discrimination, calibration and net benefit were calculated. Results The prevalence of LNI was 6.1% (120/1983 patients) and during the follow-up period, 82 patients (4.1%) experienced LN progression. On multivariable analyses, the most informative independent predictors were tumour stage (cT3-4 vs cT1-2, odds ratio [OR] 1.52, P = 0.05), clinical nodal status [cN1 vs cN0, OR 7.09, P < 0.001], metastases at diagnosis (OR 3.04, P < 0.001) and clinical tumour size (OR 1.14, P < 0.001). The accuracy of the multivariable model was found to be 86.9%, with excellent calibration and net benefit at decision-curve analyses. Conclusions By relying on a unique approach, combining the risk of harbouring LNI and/or LN progression during the follow-up period, we have provided the first clinical presurgery model predicting the need for LND.

Published
2013

248. Impact of the introduction of a robotic training programme on prostate cancer stage migration at a single tertiary referral centre

Author

Briganti, A, Bianchi, M, Sun, M, Suardi, N, Gallina, A, Abdollah, F, Bertini, R, Colombo, R, Di Girolamo, V, Salonia, A, Scattoni, V, Karakiewicz, Pi, Guazzoni, G, Rigatti, P, Montorsi, F, Briganti, Alberto, Bianchi, M, Sun, M, Suardi, N, Gallina, A, Abdollah, F, Bertini, R, Colombo, R, Girolamo, Vd, Salonia, Andrea, Scattoni, V, Karakiewicz, Pi, Guazzoni, G, Rigatti, P, and Montorsi, Francesco

Subjects
Male, Prostatectomy, Urology, Medicine (all), Tertiary Care Center, Middle Aged, prostate cancer, radical prostatectomy, minimally invasive treatment, Robotic, Italy, Retrospective Studie, Prostatic Neoplasm, Education, Medical, Continuing, Aged, Human, Neoplasm Staging, Program Evaluation
Abstract

What's known on the subject? and What does the study add? Previous studies have retrospectively compared functional and oncological outcomes between robot-assisted radical prostatectomy (RARP) and open retropubic radical prostatectomy (RRP), reporting non-inferior or superior outcomes associated with the use of the robotic approach. The study demonstrates that baseline selection biases makes comparisons of RARP and RRP problematic. Patients treated with RARP may have significantly better baseline characteristics than patients treated with RRP. Indeed, when both facilities are available within the same centre, patients with the most favourable clinical and cancer profile are inherently selected to RARP. In the absence of a prospective randomized trial, the decision to prefer one approach over another should be tailored according to each single patient and surgeon. Objective To evaluate the trend in robot-assisted radical prostatectomy (RARP) and open retropubic radical prostatectomy (RRP) use over time and to compare preoperative and pathological characteristics of patients treated with RARP or RRP at a single centre. Patients and Methods Between 2006 and 2010, 2511 consecutive patients treated with RP, with or without pelvic lymph node dissection (PLND), for prostate cancer (PCa) at a single tertiary care centre were analysed. Baseline patient characteristics and PCa risk distribution were compared according to treatment type (RRP vs RARP) in the overall population, as well as in three surgeons' initial 50 RARP and three surgeons' initial 50 RRP cases (n = 300). We used a chi-squared trend test to evaluate the differences in treatment type administration over time according to PCa characteristics. Logistic regression analyses focused on the prediction of PLND and adjuvant radiotherapy (RT) use. Results Overall, 1873 (74.6%) and 638 (25.4%) patients underwent RRP and RARP, respectively. Men treated with RARP were younger (mean age: 62 vs 65 years), less obese (mean BMI: 24.8 vs 26.4kg/m2), healthier (Charlson comorbidity index = 0: 68.7 vs 53.3%) and more likely to harbour clinical low-risk PCa (51 vs 30%) than their RRP counterparts (all P < 0.001). Similar findings were observed in sub-analyses focusing on six surgeons' 50 initial patients (all P 0.02). A significant increase in the rate of patients with low-risk PCa treated with RARP vs RRP was reported over time (5 vs 95% and 66 vs 34% in 2006 and 2010, respectively). Conversely, 76% of patients with high risk PCa were still treated with RRP in 2010. Patients treated with RARP were less likely to receive PLND at RP and adjuvant RT (all P 0.01), even after adjusting for clinical and PCa characteristics. Conclusions The introduction of a robotic training programme at a high volume centre led to significant patient selection in terms of clinical and PCa characteristics. When both RRP and RARP facilities are available within the same centre, patients with the most favourable clinical and cancer profile are selected to undergo RARP. Use of RARP negatively influenced the rates and the extent of PLND as well as the use of adjuvant RT after surgery. Thus, baseline patient selection, surgical and treatment biases make any comparisons of RARP with RRP problematic.

Published
2013

249. Time to recurrence is a significant predictor of cancer-specific survival after recurrence in patients with recurrent renal cell carcinoma - Results from a comprehensive multi-centre database (CORONA/SATURN-Project)

Author

Brookman May, S., May, M., Shariat, S., Novara, Giacomo, Zigeuner, R., Cindolo, L., Cobelli, O. D., Nunzio, C. D., Pahernik, S., Wirth, M., Longo, N., Simonato, A., Serni, S., Siracusano, S., Volpe, A., Morgia, G., Bertini, R., Dalpiaz, O., Stief, C., Ficarra, Vincenzo, Brookman-May, S. D., May, M., Shariat, S. F., Novara, G., Zigeuner, R., Cindolo, L., De Cobelli, O., De Nunzio, C., Pahernik, S., Wirth, M. P., Longo, N., Simonato, A., Serni, S., Siracusano, S., Volpe, A., Morgia, G., Bertini, R., Dalpiaz, O., Stief, C., Ficarra, V., Sabine D., Brookman May, Matthias, May, Shahrokh F., Shariat, Giacomo, Novara, Richard, Zigeuner, Luca, Cindolo, Ottavio De, Cobelli, Cosimo De, Nunzio, Sascha, Pahernik, Manfred P., Wirth, Nicola, Longo, Alchiede, Simonato, Sergio, Serni, Siracusano, Salvatore, Alessandro, Volpe, Giuseppe, Morgia, Roberto, Bertini, Orietta, Dalpiaz, Christian, Stief, Vincenzo, Ficarra, Brookman-May, Sabine D., May, Matthias, Shariat, Shahrokh F., Novara, Giacomo, Zigeuner, Richard, Cindolo, Luca, De Cobelli, Ottavio, De Nunzio, Cosimo, Pahernik, Sascha, Wirth, Manfred P., Longo, Nicola, Simonato, Alchiede, Serni, Sergio, Volpe, Alessandro, Morgia, Giuseppe, Bertini, Roberto, Dalpiaz, Orietta, Stief, Christian, and Ficarra, Vincenzo

Subjects
Male, renal cell carcinoma, Time Factors, Time Factor, Databases, Factual, Prognosi, Urology, prognostic parameter, early recurrence, time to recurrence, cancer-specific survival, Retrospective Studie, late recurrence, nephrectomy, Humans, cancer survival, Carcinoma, Renal Cell, renal cell carcinoma (RCC), prognostic parameters, Aged, Retrospective Studies, Kidney Neoplasm, Middle Aged, Prognosis, Kidney Neoplasms, Survival Rate, Female, Neoplasm Recurrence, Local, renal cell carcinoma (rcc), Human
Abstract

Objectives To assess the prognostic impact of time to recurrence (TTR) on cancer-specific survival (CSS) after recurrence in patients with renal cell carcinoma (RCC) undergoing radical nephrectomy or nephron-sparing surgery. To analyse differences in clinical and histopathological criteria between patients with early and late recurrence. Patients and Methods Of 13 107 patients with RCC from an international multicentre database, 1712 patients developed recurrence in the follow-up (FU), at a median (interquartile range) of 50.1 (25-106) months. In all, 1402 patients had recurrence at ≤5 years (Group A) and 310 patients beyond this time (Group B). Differences in clinical and histopathological variables between patients with early and late recurrence were analysed. The influence of TTR and further variables on CSS after recurrence was assessed by Cox regression analysis. Results Male gender, advanced age, tumour diameter and stage, Fuhrman grade 3-4, lymphovascular invasion (LVI), and pN + stage were significantly more frequent in patients with early recurrence, who had a significantly reduced 3-year CSS of 30% compared with patients in Group B (41%; P = 0.001). Age, gender, tumour histology, pT stage, and continuous TTR (hazard ratio 0.99, P = 0.006; monthly interval) independently predicted CSS. By inclusion of dichotomised TTR in the multivariable model, a significant influence of this variable on CSS was present until 48 months after surgery, but not beyond this time. Conclusions Advanced age, male gender, larger tumour diameters, LVI, Fuhrman grade 3-4, pN + stage, and advanced tumour stages are associated with early recurrence. Up to 4 years from surgery, a shorter TTR independently predicts a reduced CSS after recurrence. © 2013 The Authors. BJU International © 2013 BJU International.

Published
2013

250. Erratum to: Hadron transverse momentum distributions in muon deep inelastic scattering at 160 GeV/c [European Physical Journal C, 73, 2531, (2013), DOI:10.1140/epjc/s10052-013-2531-6]

Author

Adolph, C, Alekseev, MG, Alexakhin, VY, Alexandrov, Y, Alexeev, GD, Amoroso, A, Andrieux, V, Austregesilo, A, Badełek, B, Balestra, F, Barth, J, Baum, G, Bedfer, Y, Berlin, A, Bernhard, J, Bertini, R, Bicker, K, Bieling, J, Birsa, R, Bisplinghoff, J, Boer, M, Bordalo, P, Bradamante, F, Braun, C, Bravar, A, Bressan, A, Büchele, M, Burtin, E, Capozza, L, Chiosso, M, Chung, SU, Cicuttin, A, Crespo, ML, Dalla Torre, S, Dasgupta, SS, Dasgupta, S, Denisov, OY, Donskov, SV, Doshita, N, Duic, V, Dünnweber, W, Dziewiecki, M, Efremov, A, Elia, C, Eversheim, PD, Eyrich, W, Faessler, M, Ferrero, A, Filin, A, Finger, M, Finger Jr, M, Fischer, H, Franco, C, du Fresne von Hohenesche, N, Friedrich, JM, Frolov, V, Garfagnini, R, Gautheron, F, Gavrichtchouk, OP, Gerassimov, S, Geyer, R, Giorgi, M, Gnesi, I, Gobbo, B, Goertz, S, Grabmüller, S, Grasso, A, Grube, B, Gushterski, R, Guskov, A, Guthörl, T, Haas, F, von Harrach, D, Heinsius, FH, Herrmann, F, Heß, C, Hinterberger, F, Höppner, C, Horikawa, N, d’Hose, N, Huber, S, Ishimoto, S, Ivanshin, Y, Iwata, T, Jahn, R, Jary, V, Jasinski, P, Joosten, R, Kabuß, E, Kang, D, Ketzer, B, Khaustov, GV, Khokhlov, YA, Kisselev, Y, Klein, F, and Klimaszewski, K

Published
2015

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