544 results on '"Benites-Zapata, Vicente A."'
Search Results
202. Accuracy of loop-mediated isothermal amplification for the diagnosis of Clostridium difficile infection: a systematic review
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Lloyd, Aaron, primary, Pasupuleti, Vinay, additional, Thota, Priyaleela, additional, Pant, Chaitanya, additional, Rolston, David D.K., additional, Hernandez, Adrian V., additional, Benites-Zapata, Vicente A., additional, Fraser, Thomas G., additional, Donskey, Curtis J., additional, and Deshpande, Abhishek, additional
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- 2015
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203. Effect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes: a systematic review and meta-analysis of randomized controlled trials
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Pérez-López, Faustino R., primary, Pasupuleti, Vinay, additional, Mezones-Holguin, Edward, additional, Benites-Zapata, Vicente A., additional, Thota, Priyaleela, additional, Deshpande, Abhishek, additional, and Hernandez, Adrian V., additional
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- 2015
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204. A Systematic Review of the Relative Efficacy and Toxicity of Treatment Regimens for HIV-Associated Cerebral Toxoplasmosis: Is Trimephoprim-Sulfamethaxozole a Real Option?
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Thota, Priyaleela, primary, Deshpande, Abhishek, additional, Pellegrino, Daniela, additional, Pasupuleti, Vinay, additional, Benites-Zapata, Vicente, additional, Vidal, José, additional, and Hernandez, Adrian V., additional
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- 2015
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205. Mortality in patients with chronic kidney disease undergoing hemodialysis in a public hospital of Peru
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Herrera-Añazco, Percy, primary, Benites-Zapata, Vicente, additional, Hernandez, Adrian V., additional, Mezones-Holguin, Edward, additional, and Silveira-Chau, Manuela, additional
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- 2015
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206. Chronic kidney disease in Peru: a challenge for a country with an emerging economy
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Herrera-Añazco, Percy, primary, Benites-Zapata, Vicente A., additional, León-Yurivilca, Ivan, additional, Huarcaya-Cotaquispe, Rosembert, additional, and Silveira-Chau, Manuela, additional
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- 2015
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207. Usefulness of Neutrophil-to-Lymphocyte Ratio in Risk Stratification of Patients With Advanced Heart Failure
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Benites-Zapata, Vicente A., primary, Hernandez, Adrian V., additional, Nagarajan, Vijaiganesh, additional, Cauthen, Clay A., additional, Starling, Randall C., additional, and Wilson Tang, W.H., additional
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- 2015
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208. No toda hernia lumbar causa lumbalgia.
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Gil Huayanay, Delia, Benites Zapata, Vicente, and Ramirez La Torre, Carlos Alberto
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After a long series of terms used to define the displacement of disc material (either the nucleus pulposus or the fibrous ring), herniated discs were classified as bulging, focal protrusion, extrusion and sequestration. Herniated discs represent from 1% to 3% of all causes of low back pain. However, not all herniated discs are necessarily symptomatic: the presence or absence of symptoms depend on the size, location and extent of the herniated disc material in relation to the spinal canal, and whether or not it compromises the nerve roots. Several studies using magnetic resonance imaging and CT scans were performed during the 1980s and 1990s to asymptomatic individuals, and a significant number of these individuals who did not have any type of pain had disc protrusion and bulging. [ABSTRACT FROM AUTHOR]
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- 2017
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209. Factors associated with not receiving the primary series and booster dose of the COVID-19 vaccine among Venezuelan migrants in Peru: A population-based cross-sectional study.
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Al-kassab-Córdova, Ali, Silva-Perez, Claudia, Mendez-Guerra, Carolina, Herrera-Añazco, Percy, and Benites-Zapata, Vicente A.
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Ensuring broad COVID-19 vaccination coverage among migrants is a global public health concern. Thus, our study aimed to assess the factors associated with not receiving the primary series and booster dose of the COVID-19 vaccine among Venezuelan migrants in Peru. This was a cross-sectional study based on secondary data analysis of the 2022 Venezuelan Population Residing in Peru Survey. Our population included Venezuelan migrants and refugees over 18 years old living in Peru with complete information for the variables of interest. Two outcome variables were assessed: not receiving the primary series and not receiving the booster dose of the COVID-19 vaccine. Crude and adjusted prevalences were calculated with 95% confidence intervals. A total of 7,727 Venezuelan adults were included in our study, of whom 6,511 completed the primary series. The overall COVID-19 vaccination coverage of the primary series was 84.17%, whilst the coverage of the booster dose was 28.06%. Being younger, uninsured, illegally-staying, and having a low educational level were associated with both outcomes. Several sociodemographic and migration-related variables were associated with both outcomes. Governmental policies prioritizing vaccination among Venezuelan migrants are needed to ensure broad coverage in this vulnerable group. [ABSTRACT FROM AUTHOR]
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- 2023
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210. Inequalities in COVID-19 vaccination coverage in Peru: An ecological study
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Al-kassab-Córdova, Ali, Mendez-Guerra, Carolina, Silva-Perez, Claudia, Herrera-Añazco, Percy, and Benites-Zapata, Vicente A.
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To assess the correlation between COVID-19 vaccination coverage and the Human Development Index (HDI) at the provincial level in Peru.
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- 2023
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211. Self-Medication in Peru During the COVID-19 Pandemic: How Harmless It Could Be?
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Benites-Meza, Jerry K., Mejia-Bustamante, Angela, Monzon-Monge, Danixa, Urrunaga-Pastor, Diego, and Benites-Zapata, Vicente A.
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COVID-19 pandemic ,SELF medication - Published
- 2022
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212. Zero by 2030 and OneHealth: The multidisciplinary challenges of rabies control and elimination.
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Bonilla-Aldana, D. Katterine, Ruiz-Saenz, Julian, Martinez-Gutierrez, Marlen, Villamil-Gomez, Wilmer, Mantilla-Meluk, Hugo, Arrieta, German, León-Figueroa, Darwin A., Benites-Zapata, Vicente, Barboza, Joshuan J., Muñoz-Del-Carpio-Toia, Agueda, Franco, Oscar H., Cabrera, Maritza, Sah, Ranjit, Al-Tawfiq, Jaffar A., Memish, Ziad A., Amer, Fatma A., Suárez, José Antonio, Henao-Martinez, Andres F., Franco-Paredes, Carlos, and Zumla, Alimuddin
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- 2023
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213. Características de los pacientes diabéticos hospitalizados en dos hospitales de EsSalud Piura.
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Espinoza-Morales, Frank, Benites-Zapata, Vicente A., Cardoza-Jiménez, Kennlly, Quezada-Osoria, Marita, and Chumbes-Aguirre, Maryuri
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Objective: To describe the frequency of patients with diabetes mellitus type 2 hospitalized in Piura. Material and Methods: we conducted a cross-sectional study in two hospitals of greater complexity care of EsSalud in Piura: Hospital III Jose Cayetano Heredia and Hospital II Jorge Reátegui Delgado. Results: We obtained the clinical-demographic characteristics of the participants during the International Diabetes Day 2014. Of the 183 in patients in both centers, 39 patients (21%) had diabetes mellitus type 2; the mean age was 67.8 ±11.8. The medical records do not report hospital admission blood glucose and blood glucose during hospitalizaron in 17 and 24 participants, respectively. The medical records do not report weight of 31 participants. Diabetic foot was the primary cause of hospitalizaron. Conclusion: We conclude that diabetes mellitus type 2 is common in hospitalized patients of Essalud Piura, there is no proper record in the medical records of parameters such as weight and glycemic control. [ABSTRACT FROM AUTHOR]
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- 2015
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214. INMIGRANTES VENEZOLANOS EN HEMODIÁLISIS ATENDIDOS EN EL MINISTERIO DE SALUD DE PERÚ.
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Aleixandre Benites-Zapata, Vicente, Herrera-Añazco, Percy, Yarasca-Zegarra, Christopher, Venegas-Ojeda, Diego, and Flores-Benites, Vladimir
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- 2019
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215. Risk factors associated with dengue complications and death: A cohort study in Peru.
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Copaja-Corzo, Cesar, Flores-Cohaila, Javier, Tapia-Sequeiros, Gustavo, Vilchez-Cornejo, Jennifer, Hueda-Zavaleta, Miguel, Vilcarromero, Stalin, Santana-Téllez, Tomas, Parodi, José F., Gomez-Colque, Sujey, and Benites-Zapata, Vicente A.
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ARBOVIRUS diseases , *DENGUE , *THANATOLOGY , *COHORT analysis , *INTENSIVE care units , *PROGNOSIS , *FENITROTHION - Abstract
Background: Dengue has emerged as an unprecedented epidemic in Peru, and it is anticipated that this issue will escalate further owing to climate change. This study aimed to determine the risk factors associated with death from dengue in patients treated at Hospital II in Pucallpa, Peru. Methodology: This retrospective cohort study collected information from the medical records of patients with a diagnosis of dengue treated at Hospital II Pucallpa-Peru between January 2019 and March 2023. The primary outcome was death, and the secondary outcome was death, development of severe dengue, or Intensive Care Unit (ICU) admission. Cox regression models were used to determine risk factors. Findings: The clinical records of 152 patients were evaluated, with a median age of 27.5 years (interquartile range, 11–45). Among all patients, 29 (19.1%) developed severe dengue, 31 (20.4%) were admitted to the ICU, and 13 (8.6%) died during follow-up. In the survival analysis, bilirubin >1.2 mg/dL was associated with a higher risk of death aHR: 11.38 (95% CI: 1.2 106.8). Additionally, factors associated with poor prognosis included having 1 to 3 comorbidities aRR: 1.92 (1.2 to 3.2), AST ≥251 U/L aRR: 6.79 (2.2 to 21.4), history of previous dengue aRR: 1.84 (1.0 to 3.3), and fibrinogen ≥400 mg/dL aRR: 2.23 (1.2 to 4.1). Significance: Elevated bilirubin was associated with death from dengue, whereas an increase in comorbidities and a history of previous dengue were related to a poor prognosis of the disease. Early identification of severe dengue would be more feasible with improved access to laboratory testing, particularly in tropical areas with a high dengue incidence. [ABSTRACT FROM AUTHOR]
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- 2024
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216. Variations in the Prevalence of Childhood Anemia by Ethnicity Before and During the COVID-19 Pandemic in Peru.
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Muñoz-del-Carpio-Toia, Agueda, Benites-Meza, Jerry K., Herrera-Añazco, Percy, and Benites-Zapata, Vicente A.
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ANEMIA , *ETHNIC groups , *POISSON distribution , *SECONDARY analysis , *INTIMATE partner violence , *RESEARCH funding , *QUESTIONNAIRES , *STATISTICAL sampling , *HEMOGLOBINS , *MOTHERS , *DISEASE prevalence , *PERUVIANS , *DESCRIPTIVE statistics , *WATER supply , *METROPOLITAN areas , *RURAL conditions , *STATISTICS , *SOCIODEMOGRAPHIC factors , *MINORITIES , *MALNUTRITION in children , *CONFIDENCE intervals , *DATA analysis software , *PSYCHOSOCIAL factors , *COVID-19 pandemic , *VACCINATION status , *REGRESSION analysis , *CHILDREN - Abstract
We aimed to determine the variations in the prevalence of childhood anemia according to the ethnic group before and during the COVID-19 pandemic in Peru. Secondary analysis of the Demographic and Family Health Survey during 2016–2021. The outcome variable was anemia, and the exposure variable was maternal ethnicity. Also, we included sociodemographic and clinical confounding variables. We constructed generalized linear models of the Poisson family with a logarithmic link function. We evaluated 85,905 records; 30.34% had anemia, 50.83% were mestizo, 25.98% were Quechua, and 2% were Aymara. Compared with mestizos, Quechua children (PR: 1.11; 95% CI: 1.07–1.15; p < 0.001), Aymara (PR: 1.35; 95% CI: 1.27–1.44; p < 0.001), natives of the Amazon (PR: 1.20; 95% CI: 1.12–1.28; p < 0.001) and those who belonged to other indigenous peoples (PR: 1.29; 95% CI: 1.05–1.57; p = 0.013) had a higher prevalence of childhood anemia. On the contrary, compared to mestizos, white children had a lower prevalence of anemia (PR: 0.93; 95% CI: 0.89–0.99; p = 0.019). During the COVID-19 pandemic, compared to mestizos, only Quechua (PR: 1.15; 95% CI: 1.08–1.23; p < 0.001) and Aymara (PR: 1.38; 95% CI: 1.23–1.55; p < 0.001) had a higher prevalence of childhood anemia. Except for Afro-descendants, children from 6 to 59 months of age who belong to an ethnic minority had a higher probability of having childhood anemia than mestizos. However, only Quechua and Aymara children had higher odds of anemia during the COVID-19 pandemic than mestizos. [ABSTRACT FROM AUTHOR]
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- 2024
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217. Ethnic Minority Participation in Clinical Trials from Latin America and the Caribbean: A Scoping Review.
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Herrera-Añazco, Percy, Benites-Meza, Jerry K., Caira-Chuquineyra, Brenda, Fernandez-Guzman, Daniel, Hernandez-Bustamante, Enrique A., and Benites-Zapata, Vicente A.
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PATIENT selection , *MEDICAL information storage & retrieval systems , *HEALTH literacy , *HUMAN research subjects , *CLINICAL trials , *MAYAS , *EDUCATIONAL outcomes , *TREATMENT effectiveness , *SYSTEMATIC reviews , *MEDLINE , *LITERATURE reviews , *MEDICAL databases , *NUTRITIONAL status , *MINORITIES , *ONLINE information services , *DATA analysis software , *BIOMARKERS - Abstract
We summarize the clinical trials (CTs) main characteristics, including members of ethnic minorities from Latin America. We carried out a systematic search in six databases. We made a descriptive synthesis of CTs, summarizing the characteristics, interventions, main findings, results, and conclusions reported. 4411 studies were acquired in search strategy, leaving 24 CTs in the final selection. Of these, ten were randomized, four were non-randomized, and the remainder had other designs. Most of the studies were carried out in the population of infants and children (08), ten of the studies included only women, and two studies included men. Nine studies were conducted in Mexico, with the Mayan ethnic minority being mostly evaluated (05). In only 15 it was mentioned that their research was approved by a research ethics committee. Finally, half of the CTs reported funding from international agencies and third reported funding from government agencies. Our results show that that CTs in ethnic minorities are limited and reduced to a few native peoples of the continent. [ABSTRACT FROM AUTHOR]
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- 2024
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218. High serum ferritin levels are associated with insulin resistance but not with impaired glucose tolerance in a healthy people population.
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Aguirre, Luis G., Urrunaga-Pastor, Diego, Moncada-Mapelli, Enrique, Guarnizo-Poma, Mirella, Lazaro-Alcantara, Herbert, and Benites-Zapata, Vicente A.
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Aim To assess the association between elevated serum ferritin levels and the presence of insulin resistance (IR) or impaired glucose tolerance (IGT) in a population of individuals with no endocrine or metabolic disorders background. Methods Analytical cross-sectional study, carried out in adults of both sexes with no medical history of type 2 diabetes mellitus (T2DM) or other metabolic or endocrine disorder, who attended the outpatient service of a private clinic in Lima-Peru during 2012–2014 period. Impaired serum ferritin levels were defined as serum ferritin values >300 μg/L in men and >200 μg/L in women. IR was defined as a Homeostasis Model Assessment (HOMA-IR) value ≥3.8 and IGT was defined as an oral glucose tolerance test (OGTT) value between 126 mg/dL and 199 mg/dL. The reported association measure was the prevalence ratio (PR) with their respective 95% confidence intervals (95% CI). Results We analyzed 213 participants, the average age was 35.8 ± 11.1 years and 35.7% were males. The prevalence of impaired serum ferritin levels, IR and IGT in the population was 12.7%, 33.3% and 9.9% respectively. In the adjusted Poisson regression models, the prevalence of IR was higher among the group with impaired serum ferritin levels (PR = 1.74; 95%CI:1.18–2.56); however, we found no association between impaired serum ferritin levels and IGT (PR = 1.42; 95%CI:0.47–4.30). Conclusions Impaired levels of serum ferritin are associated with IR, nevertheless, not with IGT in a metabolically healthy population. Serum ferritin could be considered as an early marker of IR prior to the onset of glycaemia disorders. [ABSTRACT FROM AUTHOR]
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- 2017
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219. Access to HIV/STI testing among male and female Venezuelan migrants in Peru: evidence from a nationwide survey.
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Al-kassab-Córdova, Ali, Mendez-Guerra, Carolina, Robles-Valcarcel, Pamela, Bendezu-Quispe, Guido, and Benites-Zapata, Vicente A.
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SEXUALLY transmitted diseases , *HIV , *SECONDARY analysis , *VENEZUELANS , *IMMIGRANTS - Abstract
Background: Human immunodeficiency virus (HIV) infection and sexually transmitted infections (STIs) are major global public health issues. Migrants represent a vulnerable group that faces multiple barriers to access to healthcare services, including HIV/STI testing. This study aimed to assess the factors associated with access to HIV/STI testing in male and female Venezuelan migrants in Peru. Methods: This was a cross-sectional study involving secondary data analysis of the 2022 Venezuelan Population Residing in Peru Survey. The study was conducted in the eight most populated cities inhabited by Venezuelan migrants and refugees. For each city, the sampling design was probabilistic, stratified, and independent. The outcome variable was whether participants had access to HIV or other STI testing during their stay in Peru. Statistical analysis was stratified by sex owing to potential effect modification. Crude and adjusted prevalence ratios were calculated using generalized linear models Poisson family with log link function. Confidence intervals were calculated to 95%. Results: A total of 3,723 male and 3,984 female migrants were included. Access to HIV/STI testing among male and female migrants was 19.85% and 25.16%, respectively. Among male migrants, being LGBTI, health insured, and married or cohabiting were associated with increased access to HIV/STI testing. Among females, those aged 18–44 years, those who were married or cohabiting and were health insured, and those residing for more than 1 year in Peru were significantly more likely to have access to HIV/STI testing. Moreover, physical/mental disability and unemployed status were associated with a lower probability of HIV/STI testing in females. Conclusions: Only two in ten Venezuelan migrants and refugees in Peru were screened for HIV/STI, with fewer males than females. Sex-specific sociodemographic, health-related, and migration-related variables were independently associated with access to HIV/STI testing. [ABSTRACT FROM AUTHOR]
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- 2024
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220. Retraction of health science articles by researchers in Latin America and the Caribbean: A scoping review.
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Herrera‐Añazco, Percy, Fernandez‐Guzman, Daniel, Barriga‐Chambi, Fernanda, Benites‐Meza, Jerry K., Caira‐Chuquineyra, Brenda, and Benites‐Zapata, Vicente Aleixandre
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We aimed to conduct a scoping review to assess the profile of retracted health sciences articles authored by individuals affiliated with academic institutions in Latin America and the Caribbean (LAC). We systematically searched seven databases (PubMed, Scopus, Web of Science, Embase, Medline/Ovid, Scielo, and LILACS). We included articles published in peer‐reviewed journals between 2003 and 2022 that had at least one author with an institutional affiliation in LAC. Data were collected on the year of publication, study design, authors' countries of origin, number of authors, subject matter of the manuscript, scientific journals of publication, retraction characteristics, and reasons for retraction. We included 147 articles, the majority being observational studies (41.5%). The LAC countries with the highest number of retractions were Brazil (n = 69), Colombia (n = 16), and Mexico (n = 15). The areas of study with the highest number of retractions were infectology (n = 21) and basic sciences (n = 15). A retraction label was applied to 89.1% of the articles, 70.7% were retracted by journal editors, and 89.1% followed international retraction guidelines. The primary reasons for retraction included errors in procedures or data collection (n = 39), inconsistency in results or conclusions (n = 37), plagiarism (n = 21), and suspected scientific fraud (n = 19). In conclusion, most retractions of scientific publications in health sciences in LAC adhered to international guidelines and were linked to methodological issues in execution and scientific misconduct. Efforts should be directed toward ensuring the integrity of scientific research in the field of health. [ABSTRACT FROM AUTHOR]
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- 2024
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221. Neutrophil-to-lymphocyte ratio and survival outcomes in testicular cancer: A systematic review and meta-analysis.
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Campos-Aspajo, Alvaro, Caman-Peña, Daniela, Ulloque-Badaracco, Juan R., Hernandez-Bustamante, Enrique A., Alarcón-Braga, Esteban A., Mosquera-Rojas, Melany D., Herrera-Añazco, Percy, and Benites-Zapata, Vicente A.
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NEUTROPHIL lymphocyte ratio , *TESTICULAR cancer , *CANCER diagnosis - Abstract
Background: The neutrophil-to-lymphocyte ratio (NLR) is a biomarker in inflammatory processes associated with multiple unfavorable outcomes in various diseases. This study aims to evaluate the association between NLR values and survival outcomes in patients diagnosed with testicular cancer. Methods: A systematic search was conducted in 6 electronic databases to retrieve studies evaluating NLR in patients with testicular cancer. The outcomes sought were overall survival (OS) and progression-free survival (PFS), and the effect measures were hazard ratio (HR) with a 95% confidence interval (CI). A random effects model was used for the meta-analysis. The risk of bias included in the studies was assessed according to the Newcastle-Ottawa Scale criteria. Egger test and Trim-and-fill method were used to test the publication bias among articles. Results: Six cohort studies (n= 1315) were evaluated. High NLR values are associated with a higher risk of OS (HR: 1.75; 95% CI 1.04 - 2.92, I2: 65%). However, no statistically significant association was found between NLR and PFS values. We found publication bias in the association between NLR and OS (Egger test < 0.1). This bias was corrected by using the trimand-fill method (HR: 1.38, 95% CI 0.85 - 2.22) Conclusions: High NLR values are associated with worse OS; however, this result had publication bias, and the association was lost when this bias was corrected. Furthermore, no statistically significant association was found between NLR values and PFS. [ABSTRACT FROM AUTHOR]
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- 2024
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222. Telomere Length in Patients with Gestational Diabetes Mellitus and Normoglycemic Pregnant Women: a Systematic Review and Meta-analysis.
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Pérez-López, Faustino R., López-Baena, María T., Ulloque-Badaracco, Juan R., and Benites-Zapata, Vicente A.
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We performed a systematic review and meta-analysis of studies assessing telomere length in blood leukocytes or mononuclear cells in women with gestational diabetes mellitus (GDM) and normoglycemic pregnant women (NPW) and their infants. The review protocol was registered in PROSPERO (CRD42022300950). Searches were conducted in PubMed, Embase, LILACS, CNKI, and Wang Fang, from inception through November 2022. The primary outcomes were maternal and offspring telomere length. The Newcastle-Ottawa Scale was used to assess the quality of included studies. Random-effect meta-analyses were applied to estimate standardized mean differences (SMDs) and their 95% confidence interval (CI). The meta-analysis of four studies showed no significant maternal telomere length difference (SMD = −0.80, 95% CI: −1.66, 0.05) in women with GDM compared to NPW. In the sensibility analysis omitting one study with a small sample of women, the telomere length becomes significantly reduced in women with GDM (SMD = −1.10, 95% CI: −2.18, −0.02). GDM patients had increased glucose (SMD = 0.28, 95% CI: 0.09, 0.46) and glycosylated hemoglobin than NPW (SMD = 0.62, 95% CI: 0.23, 1.01) while total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides did not display differences between women with and without GDM. There was no significant difference in cord blood telomere length in offspring from women with GDM and NPW (SMD = 0.11, 95% CI: −0.52, 0.30). Cord blood insulin levels (SMD = 0.59, 95% CI: 0.33, 0.85) and birthweight (SMD = 0.59, 95% CI: 0.39, 0.79) were higher in offspring from pregnant women with GDM than in those from NPW. There were no significant differences in maternal and offspring telomere length between pregnancies with and without GDM. [ABSTRACT FROM AUTHOR]
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- 2024
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223. Efficacy and Safety of Aripiprazole in Borderline Personality Disorder: A Systematic Review.
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Valdivieso-Jiménez, Glauco, Pino-Zavaleta, Dennis Anthony, Campos-Rodriguez, Susan K., Ortiz-Saavedra, Brando, Fernández, María F., and Benites-Zapata, Vicente Aleixandre
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BORDERLINE personality disorder , *ARIPIPRAZOLE , *CLINICAL trials , *ANTIPSYCHOTIC agents , *PATIENT safety - Abstract
Aripiprazole is an atypical antipsychotic medication, and its use in treating borderline personality disorder (BPD) is debatable because it is not FDA-approved for treating BPD. This study aimed to investigate the efficacy and safety of aripiprazole in patients with BPD. On July 2, 2021, the protocol (CRD42021256647) was registered in PROSPERO. PubMed, Scopus, Web of Science, Ovid-Medline, Embase, PsycINFO, and Cochrane (CENTRAL) were searched without regard for language or publication date. We also searched trial registries on ClinicalTrials.gov and the WHO International Clinical Trials Registry Platform. Randomized clinical trials with adult patients diagnosed with BPD met the inclusion criteria. The Cochrane risk of bias for randomized trials (RoB-2) method was used to assess the quality of the included studies. We included two previously published randomized clinical trials. There were 76 patients with BPD, with 38, 12, and 26 assigned to the aripiprazole, olanzapine, and placebo groups, respectively. Most patients (88.16%) were females, with ages ranging from 22.1 to 28.14 yr. Aripiprazole has been proven to reduce anxiety, depression, anger, hostility, clinical severity, and obsessive–compulsive behavior, insecurity, melancholy, anxiety, aggressiveness/hostility, phobic anxiety, paranoid thinking, psychoticism, and somatization. The adverse effects were headache, insomnia, restlessness, tremor, and akathisia. The risk of bias was considerable in both trials, which is somewhat problematic considering that prejudice can lead to incorrect outcomes and conclusions. Aripiprazole has demonstrated encouraging outcomes in the treatment of patients with BPD. More randomized controlled studies are needed. [ABSTRACT FROM AUTHOR]
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- 2023
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224. Socio-demographic, migratory and health-related determinants of food insecurity among Venezuelan migrants in Peru.
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Al-kassab-Córdova, Ali, Villarreal-Zegarra, David, Bendezu-Quispe, Guido, Robles-Valcárcel, Pamela, Herrera-Añazco, Percy, and Benites-Zapata, Vicente A.
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FOOD security , *VENEZUELANS , *PSYCHOMETRICS , *RASCH models , *SECONDARY analysis , *MINORITY stress - Abstract
Objective: To evaluate the factors associated with food insecurity (FI) among Venezuelan migrants residing in Peru. Secondarily, to evaluate the psychometric properties of the Food Insecurity Experience Scale (FIES). Design: A cross-sectional study based on secondary data analysis of the 2022 Venezuelan Population Residing in Peru Survey (ENPOVE-2022, from the Spanish acronym) was conducted. FI was measured with the FIES, whose properties were tested using the Rasch model. Multinomial logistic regression was performed to estimate relative prevalence ratios with their corresponding 95 % confidence intervals. Setting: This survey was conducted in February and March 2022 in the eight cities most populated by Venezuelan migrants and refugees in Peru. Participants: Venezuelan migrants and refugees over the age of 18 years living in Peru. Results: A total of 7727 participants were included. Rasch reliability was adequate (0·73). The prevalence of mild, moderate and severe FI was 36·71 %, 31·14 % and 10·48 %, respectively. Being aged 25–34 and 35–44 years, unemployed, uninsured, having no formal education or secondary, illegal status, living in a dwelling with 2–4 and more than 4 people, presenting one or more than one chronic disease, residing in Peru for 0–6 months and perceived discrimination were associated with a higher probability of moderate FI. Furthermore, having secondary education, being unemployed, uninsured, never married, illegal, residing in Tumbes, presenting one or more than one chronic disease and perceived discrimination were significantly associated with severe FI. Conclusion: Four out of ten Venezuelan migrants residing in Peru presented moderate to severe FI. The FIES showed adequate psychometric properties. Differences in the socio-demographic, health and migratory factors associated with FI levels were found. Inter-sectoral and multi-sectoral interventions are needed and should be focused on addressing the determinants of FI. [ABSTRACT FROM AUTHOR]
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- 2023
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225. Endometrial telomerase activity in women with either endometrial cancer or hyperplasia: A systematic review and meta-analysis.
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Pérez-López, Faustino R., Ulloque-Badaracco, Juan R., López-Baena, María T., Yuan, Junhua, Alarcón-Braga, Esteban A., and Benites-Zapata, Vicente A.
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ENDOMETRIAL hyperplasia , *ENDOMETRIAL cancer , *TELOMERASE , *CANCER patients , *ODDS ratio - Abstract
• Endometrial telomerase is increased in women with endometrial cancer. • Endometrial telomerase is increased in women with endometrial hyperplasia. • Women from different continents have similar results. We performed a systematic review and meta-analysis to assess whether endometrial telomerase activity is associated with endometrial cancer or hyperplasia. PubMed, Web of Science, Embase, Scielo, LILAC, and CNKI databases were searched to obtain relevant literature for articles published through June 2022, following PRISMA guidelines and a registered PROSPERO protocol. We included observational studies reporting endometrial telomerase activity in patients with either endometrial cancer or hyperplasia compared with benign endometrial tissue (control women). The Newcastle-Ottawa Scale was used to evaluate the quality of studies. Data were expressed as the odds ratios (OR) and 95 % confidence intervals (CI). Random effects and inverse variance methods were used to meta-analyze associations. The I 2 test was used to assess heterogeneity. There were significant associations between endometrial telomerase activity and either endometrial cancer (20 studies, OR = 10.65, 95 % CI 6.39, 17.75, p = 0.00001, I 2 = 21 %) or endometrial hyperplasia (nine studies, OR = 3.62, 95 % CI 1.61, 8.13, p = 0.002, I 2 = 36 %) compared to women without endometrial cancer and hyperplasia. There was not a significant difference in telomerase activity in women with endometrial cancer compared to those with endometrial hyperplasia (seven studies, OR = 1.03; 95 % CI 0.31, 3.37, p = 0.96, I 2 = 49 %). In subgroup analyses, there were no significant differences in telomerase activity in patients with endometrial cancer by type of observational studies and by countries of the studies. Endometrial telomerase activity is higher in women with either endometrial cancer or endometrial hyperplasia compared to control women without those lesions. [ABSTRACT FROM AUTHOR]
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- 2023
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226. Association of apolipoproteins and lipoprotein(a) with metabolic syndrome: a systematic review and meta-analysis.
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Ulloque-Badaracco, Juan R., Al-kassab-Córdova, Ali, Hernandez-Bustamante, Enrique A., Alarcon-Braga, Esteban A., Huayta-Cortez, Miguel, Carballo-Tello, Ximena L., Seminario-Amez, Rosa A., Herrera-Añazco, Percy, and Benites-Zapata, Vicente A.
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APOLIPOPROTEINS , *METABOLIC syndrome , *APOLIPOPROTEIN A , *INSULIN resistance , *HEART metabolism disorders , *LIPOPROTEINS , *APOLIPOPROTEIN E4 - Abstract
Background & aims: Apolipoproteins and lipoprotein(a) are associated with various cardiometabolic diseases, including insulin resistance, diabetes mellitus, hypertension, dyslipidemia, among others. This systematic review and meta-analysis was conducted to evaluate the association of these markers with metabolic syndrome (MetS). Methods: We ran a systematic search through PubMed, Scopus, Embase, Ovid/Medline, and Web of Science on March 15, 2023. No language or date restrictions were applied. The only synthesised effect measure reported was the odds ratio (OR) with its corresponding 95% confidence interval (95% CI). We utilised the random-effects model for the quantitative synthesis. Results: We analysed 50 studies (n = 150 519) with different definitions for MetS. Increased ApoB values were associated with MetS (OR = 2.8; 95% CI: 2.44–3.22; p < 0.01, I2 = 99%). Decreased ApoA1 values were associated with MetS (OR = 0.42; 95% CI: 0.38–0.47; p < 0.01, I2 = 99%). Increased values of the ApoB/ApoA1 ratio were associated with MetS (OR = 4.97; 95% CI: 3.83–6.44; p < 0.01, I2 = 97%). Decreased values of Lp(a) were associated with MetS (OR = 0.89; 95% CI: 0.82–0.96; p < 0.01; I2 = 92%). Conclusions: Increased values of ApoB and ApoB/ApoA1 ratio are associated with MetS, while decreased values of ApoA1 and Lp(a) are associated with MetS. These findings suggest that these lipid markers may serve as potential indicators for identifying subjects at risk of developing MetS. However, further research is required to elucidate the underlying mechanisms of these associations. [ABSTRACT FROM AUTHOR]
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- 2023
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227. Spatial and socioeconomic inequalities in the access to safe drinking water in Peruvian households.
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Al-kassab-Córdov, Ali, Silva-Perez, Claudia, Robles-Valcarcel, Pamela, Bendezu-Quispe, Guido, Ortiz, Amado Insfrán, and Benites-Zapata, Vicente A.
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DRINKING water , *SECONDARY analysis , *HOUSEHOLDS , *DEMOGRAPHIC surveys , *DUMMY variables - Abstract
Access to safe drinking water has increased in Peru over the last decades, from 47% (2008) to 52% (2018). Nevertheless, such access would differ according to socioeconomic and regional factors. Thus, this study aimed to assess the socioeconomic inequality in the access to safe drinking water and identify its spatial distribution. We conducted a cross-sectional study based on the secondary data analysis of the 2021 Peruvian Demographic and Health Survey. Access to safe drinking water was a dummy variable categorised as safe if the residual chlorine concentration was (0.5 mg/L. Nationwide, 29.22% of households had access to safe drinking water. A pro-rich inequality in access to safe drinking water was observed. The spatial distribution was clustered. Significant hotspots were found in the south and centre of the country; however, cold spots were found in most areas. SaTScan analysis identified 32 and 63 significant clusters at high and low risks of having access to safe drinking water, respectively. In conclusion, approximately one out of four Peruvian households has access to safe drinking water, which was mostly concentrated among the wealthier households. Intra- and interdepartmental inequalities in access to safe drinking water were found, with several high-risk clusters. [ABSTRACT FROM AUTHOR]
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- 2023
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228. Systemic Immune-Inflammation Index and Mortality in Testicular Cancer: A Systematic Review and Meta-Analysis.
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Salazar-Valdivia, Farley E., Valdez-Cornejo, Valeria A., Ulloque-Badaracco, Juan R., Hernandez-Bustamante, Enrique A., Alarcón-Braga, Esteban A., Mosquera-Rojas, Melany D., Garrido-Matta, Diana P., Herrera-Añazco, Percy, Benites-Zapata, Vicente A., and Hernandez, Adrian V.
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TESTICULAR cancer , *CANCER prognosis , *CANCER-related mortality , *PROGRESSION-free survival , *OVERALL survival - Abstract
The systemic immune-inflammation index (SIII) is a marker studied in multiple types of urologic cancer. This systematic review evaluates the association between SIII values with overall survival (OS) and progression-free survival (PFS) in testicular cancer. We searched observational studies in five databases. The quantitative synthesis was performed using a random-effects model. The risk of bias was assessed using the Newcastle–Ottawa Scale (NOS). The only measure of the effect was the hazard ratio (HR). A sensitivity analysis was performed according to the risk of bias in the studies. There were 833 participants in a total of 6 cohorts. We found that high SIII values were associated with worse OS (HR = 3.28; 95% CI 1.3–8.9; p < 0.001; I2 = 78) and PFS (HR = 3.9; 95% CI 2.53–6.02; p < 0.001; I2 = 0). No indication of small study effects was found in the association between SIII values and OS (p = 0.5301). High SIII values were associated with worse OS and PFS. However, further primary studies are suggested to enhance the effect of this marker in different outcomes of testicular cancer patients. [ABSTRACT FROM AUTHOR]
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- 2023
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229. Atherogenic markers and 1-year amputation risk in adults with diabetic foot in a tertiary level hospital: A retrospective cohort study.
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Benites-Meza, Jerry K., Malo-Castillo, Jussara, Herrera-Añazco, Percy, and Benites-Zapata, Vicente A.
- Abstract
To determine the association between atherogenic markers, such as total cholesterol/high density lipoprotein cholesterol ratio (TC/HDL-C), triglycerides/HDL-C ratio (TG/HDL-C), and triglycerides-glucose index (TyG), and the risk of 1-year amputation in adults with diabetic foot in a tertiary level hospital. Retrospective cohort study conducted in 162 adult patients with diabetic foot. The outcome was amputation, defined as "primary amputation in patients' clinical history after their first hospitalization due to foot ulcer.". The cutoff point was determined using Youden's J statistic. The relative risk (RR) was presented as an association measure. A TyG index of >9.4 [RR: 1.64 (1.10–2.45)] was associated with a high risk of amputation after 1-year in adults with diabetic foot. However, while a TC/HDL ratio of >4.69 [RR: 1.38 (0.94–2.03)] and a TG/HDL-C ratio > 3.57 [RR: 1.35 (0.89–2.06)] did not show associations with risk of amputation after 1-year. Only a TyG index of >9.4 was associated with an increased risk of 1-year amputation in adults with diabetic foot. Future studies with larger samples and a longitudinal design may provide more robust evidence and a better understanding of clinical implications. • Diabetic foot is a common complication with serious consequences for quality of life. • TyG index greater than 9.4 was associated with an increased risk of amputation at 1 year in adults with diabetic foot. • Longitudinal studies with larger samples can offer stronger evidence and clarify clinical implications. [ABSTRACT FROM AUTHOR]
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- 2024
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230. Highly pathogenic avian influenza A(H5N1) in animals: A systematic review and meta-analysis.
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Bonilla-Aldana, D. Katterine, Calle-Hernández, Dayana M., Ulloque-Badaracco, Juan R., Alarcón-Braga, Esteban A., Hernández-Bustamante, Enrique A., Cabrera-Guzmán, Juan C., Quispe-Vasquez, Sthephanie M., Huayta-Cortez, Miguel A., Benites-Zapata, Vicente A., and Rodriguez-Morales, Alfonso J.
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AVIAN influenza , *BIBLIOGRAPHIC databases , *INFLUENZA viruses , *CONFIDENCE intervals , *PREVENTIVE medicine , *H7N9 Influenza - Abstract
Avian influenza A H5N1 is a significant global public health threat. Although relevant, systematic reviews about its prevalence in animals are lacking. We performed a systematic literature review in bibliographic databases to assess the prevalence of H5N1 in animals. A meta-analysis with a random-effects model was performed to calculate the pooled prevalence and 95 % confidence intervals (95%CI). In addition, measures of heterogeneity (Cochran's Q statistic and I2 test) were reported. The literature search yielded 1359 articles, of which 33 studies were fully valid for analysis, including 96,909 animals. The pooled prevalence for H5N1 in birds (n = 90,045, 24 studies) was 5.0 % (95%CI: 4.0–6.0 %; I2 = 99.21); in pigs (n = 3,178, 4 studies) was 1.0 % (95%CI: 0.0–1.0 %); in cats (n = 2,911, 4 studies) was 0.0 % (95%CI: 0.0–1.0 %); and in dogs (n = 479, 3 studies) was 0.0 % (95%CI: 0.0–2.0 %). While the occurrence of H5N1 in animals might be comparatively limited compared to other influenza viruses, its impact on public health can be substantial when it transmits to humans. This virus can potentially induce severe illness and has been linked to previous outbreaks. Therefore, it is essential to closely monitor and comprehend the factors influencing the prevalence of H5N1 in both avian and human populations to develop effective disease control and prevention strategies. [ABSTRACT FROM AUTHOR]
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- 2024
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231. Efficacy and safety of ivermectin for treatment of non-hospitalized COVID-19 patients: A systematic review and meta-analysis of 12 randomized controlled trials with 7,035 participants.
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Hernandez, Adrian V., Liu, Anna, Roman, Yuani M., Burela, Paula Alejandra, Pasupuleti, Vinay, Thota, Priyaleela, Carranza-Tamayo, Cesar O., Retamozo-Palacios, Manuel, Benites-Zapata, Vicente A., Piscoya, Alejandro, and Vidal, Jose E.
- Abstract
• We performed a systematic review and meta-analysis of randomized controlled trials (RCTs) comparing treatment with ivermectin against standard of care, placebo or active drug for non-hospitalized patients with early COVID-19; 12 RCTs were included. • Ivermectin did not reduce hospitalization, all-cause mortality or adverse events when compared with controls. • Ivermectin did not reduce mechanical ventilation, clinical worsening or serious adverse events and did not increase clinical improvement and viral clearance when compared with controls. We systematically assessed benefits and harms of the use of ivermectin in non-hospitalized patients with early COVID-19. Five databases were searched until October 17, 2023, for randomized controlled trials (RCTs) in adult patients with COVID-19 treated with ivermectin against standard of care (SoC), placebo, or active drug. Primary outcomes were hospitalization, all-cause mortality, and adverse events (AEs). Secondary outcomes included mechanical ventilation (MV), clinical improvement, clinical worsening, viral clearance, and severe adverse events (SAEs). Random effects meta-analyses were performed, with quality of evidence (QoE) evaluated using GRADE methods. Pre-specified subgroup analyses (ivermectin dose, control type, risk of bias, follow-up, and country income) and trial sequential analysis (TSA) were performed. Twelve RCTs (n = 7,035) were included. The controls were placebo in nine RCTs, SoC in two RCTs, and placebo or active drug in one RCT. Ivermectin did not reduce hospitalization (relative risk [RR], 0.81, 95% confidence interval [95% CI] 0.64–1.03; 8 RCTs, low QoE), all-cause mortality (RR 0.98, 95% CI 0.73–1.33; 9 RCTs, low QoE), or AEs (RR 0.89, 95% CI 0.75–1.07; 9 RCTs, very low QoE) vs. controls. Ivermectin did not reduce MV, clinical worsening, or SAEs and did not increase clinical improvement and viral clearance vs. controls (very low QoE for secondary outcomes). Subgroup analyses were mostly consistent with main analyses, and TSA-adjusted risk for hospitalization was similar to main analysis. In non-hospitalized COVID-19 patients, ivermectin did not have effect on clinical, non-clinical or safety outcomes versus controls. Ivermectin should not be recommended as treatment in non-hospitalized COVID-19 patients. [Display omitted] [ABSTRACT FROM AUTHOR]
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- 2024
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232. Atherogenic index of plasma and coronary artery disease: A systematic review.
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Ulloque-Badaracco, Juan R., Hernandez-Bustamante, Enrique A., Alarcon-Braga, Esteban A., Mosquera-Rojas, Melany D., Campos-Aspajo, Alvaro, Salazar-Valdivia, Farley E., Valdez-Cornejo, Valeria A., Benites-Zapata, Vicente A., Herrera-Añazco, Percy, Valenzuela-Rodríguez, Germán, and Hernandez, Adrian V.
- Abstract
This review aimed to synthesize evidence of the association between AIP values and CAD. A literature search was carried out on four databases, namely, PubMed, Scopus, Web of Science, and Ovid-Medline. A handsearch was performed on preprint repositories (MedRxiv and Research Square). The effect measurements were expressed as odds ratios (OR) with their corresponding 95% confidence intervals (CI). For the quantitative synthesis, we employed a randomeffects model. We analyzed 14 articles (with 40,902 participants) from seven different countries. The quantitative analysis revealed that an increase in one unit of AIP was associated with higher odds of developing CAD (OR 2.11; 95% CI 1.65–2.69; P < 0.001; I2 = 98%). We conducted subgroup analyses of Chinese (OR 1.89; 95% CI 1.40–2.56; P < 0.001) and non-Chinese studies (OR 2.51; 95% CI 1.42–4.42; P < 0.001). The sensitivity analysis by risk of bias continued to demonstrate an association, and the heterogeneity remained unchanged(OR 1.75; 95% CI 1.33–2.31; P < 0.001; I2 = 98%). Higher AIP values were associated with higher odds of developing CAD. [ABSTRACT FROM AUTHOR]
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- 2022
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233. Association between self-perceived consultation time and understanding of the prescribed treatment: An analysis of a national survey in Peru.
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Cabanillas-Lazo, Miguel, Benites-Meza, Jerry K., Pinedo-Castillo, Liseth, Fernandez-Quiroz, Eliana L., Pacherres-Lopez, Andres, Herrera-Añazco, Percy, and Benites-Zapata, Vicente A.
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PATIENT satisfaction , *TIME perception - Abstract
To assess the relationship between the self-perceived consultation time and the knowledge of the proposed treatment. Secondary data from a 2015 national survey of health services in Peru were analyzed. The self-perceived consultation time was calculated by asking how long it took from when you entered the consultation until you departed. It was then categorized as low, medium, and high. Five self-reported questions were used to construct a knowledge of the prescribed treatment. Adjusted regression models from the Poisson family models were used to evaluate the relationship. We report adjusted prevalence ratios (aPR) with their 95% confidence intervals (95%CI). A total of 9939 outpatients were analyzed, with 58% women; the average age was 44 years; and 45.4% had higher education. Using low self-perceived consultation time as references, medium and high consultation times were associated with understanding the prescribed treatment (aPR=1.17; 95%CI, 1.04–1.33 and aPR=1.30; 95%CI, 1.20–1.40, respectively). Patients who reported a medium and high self-perceived consultation time better understood the prescribed treatment. Healthcare professionals should strive to maximize consultation time to ensure effective communication and improve patient knowledge of treatments, improving overall patient satisfaction and health outcomes. • 71.3% of the participants perceived consultation time as between 10 and 15 min. • Seven out of 10 respondents understood the prescribed treatment. • Consultation time was associated with understanding of prescribed treatment. • This association was increased to a consultation time of 15 min. [ABSTRACT FROM AUTHOR]
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- 2024
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234. A systematic review and meta-analysis of bovine brucellosis seroprevalence in Latin America and the Caribbean.
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Bonilla-Aldana, D. Katterine, Trejos-Mendoza, Adrián Esteban, Pérez-Vargas, Soffia, Rivera-Casas, Estefany, Muñoz-Lara, Fausto, Zambrano, Lysien I., Arteaga-Livias, Kovy, Ulloque-Badaracco, Juan R., Alarcon-Braga, Esteban A., Hernandez-Bustamante, Enrique A., Al-kassab-Córdova, Ali, Benites-Zapata, Vicente A., and Rodriguez-Morales, Alfonso J.
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BRUCELLA , *BRUCELLOSIS , *SEROPREVALENCE , *ANIMAL herds , *BOS , *VETERINARY services - Abstract
Bovine brucellosis is a significant public health problem in countries with economic and zoonotic implications. Although relevant, there are no previous systematic reviews about bovine brucellosis in Latin America. We performed a systematic literature review in five data-bases to assess the seroprevalence of Brucella in cattle. A meta-analysis with a random-effects model was performed to calculate the pooled prevalence and 95% confidence intervals (95%CI). In addition, measures of heterogeneity (Cochran's Q statistic and I2 test) were reported. The literature search yielded 3,403 articles, of which 65 studies were fully valid for analysis. The pooled seroprevalence for Brucella in bovine (n = 46,883,177) was 4.0% (95%CI: 3.0%–5.0%; p < 0.001), and Venezuela was the country with the highest prevalence (16.0%). By regions, the highest seroprevalence is in Central America and the Caribbean islands (8.0%,95%CI: 3.0%–15.0%; p < 0.001, I2 = 99.85). Some countries reported still relevant seroprevalences of bovine brucellosis, especially at the Central America and Caribbean islands. Multiple factors may influence the survival and spread of pathogens in the environment; farms located in regions bordering forest areas, in areas of difficult access to the veterinary service; extensive beef herds raised at pastures with different age and productive groups inter-mingled, and minimal concerns regarding hygiene practices and disease prevention measures. Bovine brucellosis has not been eliminated and needs to be considered with new tools for prevention and control, especially being a zoonosis. [ABSTRACT FROM AUTHOR]
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- 2023
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235. Prevalence of zoonotic and non-zoonotic Rickettsia in horses: A systematic review and meta-analysis.
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Bonilla-Aldana, D. Katterine, Castaño-Betancourt, Karen Johana, Ortega-Martínez, Juan Manuel, Ulloque-Badaracco, Juan R., Hernandez-Bustamante, Enrique A., Benites-Zapata, Vicente A., and Rodriguez-Morales, Alfonso J.
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RICKETTSIA , *HORSES , *CONFIDENCE intervals - Abstract
In a broad sense, Rickettsiae are a group of microorganisms that can be transmitted mechanically or biologically to animals and humans. Rickettsioses are associated with hematic manifestations. Its prevalence in humans, dogs and other animals has been widely explored, but not in equine species. To determine the prevalence of Rickettsia infection in horses. A systematic review of the literature was carried out in five databases for the proportion of horses infected with Rickettsia , defined by molecular and immunological techniques. A meta-analysis was performed using a random-effects model to calculate the pooled prevalence and 95% confidence intervals (CI). The Cochran's Q test and the I2 statistic were used to assess the between-study-heterogeneity. The pooled prevalence of Rickettsia in equines was 37.0% (95% CI: 26.0%-47.0%), with significant heterogeneity among studies (I2 = 98.12%). In the subgroup analysis, the prevalence of Rickettsia in horses was found to be 24.0% (95%CI: 10.0%-41.0%) for IFI, 47.0% (95%CI: 30.0%-64.0%) for IFA, 14.0% (95%CI: 11.0%-17.0%) for IFAT and 39.0% (95%CI: 0.0%-95.0%) for PCR. There was a high prevalence of Rickettsia among horses, with some of the species being zoonotic, with their corresponding implications for humans, which increasingly are in close contact with equines, particularly horses and their ticks, posing a risk for spillover and transmission. [ABSTRACT FROM AUTHOR]
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- 2023
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236. Razón neutrófilos-linfocitos en el pronóstico de sobrevida en los pacientes con melanoma maligno cutáneo Instituto Nacional de Enfermedades Neoplásicas 2005-2012
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Pinto Paz, Mirian Elizabeth and Benites Zapata, Vicente
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Neutrófilos ,Supervivencia (Salud pública) ,Neoplasias cutáneas ,Linfocitos ,Melanoma - Abstract
TEXTO COMPLETO NO AUTORIZADO POR LA AUTORA Introducción: El objetivo del presente trabajo fue determinar el valor pronóstico independiente y la sobrevida de los factores clínico-patológicos más importantes. Método: Se realizó un estudio retrospectivo, descriptivo, longitudinal, aplicando el método de riesgo proporcional de Cox y el método de Kaplan Meier, buscando diferentes variables de riesgo en pacientes con diagnóstico de Melanoma Maligno Cutáneo atendidos en el INEN, en un periodo de 12 años. Resultados: El 67.6% fueron Lentigo Acrales y se localizaron en las manos y los pies. Los estadios clínicos II y III, fueron los predominantes. Los estadios 3 y el 4 tienen 3.2 y 24 veces más riesgo de morir, respectivamente, comparados con el estadio 1. Los pacientes que son mayores de 60 años tuvieron 1.51 veces mayor riesgo de morir. El sexo masculino tuvo un 1.37 veces mayor riesgo de morir. En relación con los factores clínico-patológicos, el Breslow en el modelo crudo tiene un riesgo mayor y significativo de mortalidad mientras más grueso sea. En el análisis crudo se evidenció un riesgo 2.5 veces mayor de morir en el grupo que tiene el NLR > 3. Por lo cual, el NLR es un predictor independiente de mortalidad. La supervivencia fue descendiendo según el estadio clínico y mientras la relación NLR > 3. El seguimiento de pacientes fue de 125 meses y hubo 378 defunciones. Conclusiones: La relación NLR es una buena prueba de pronóstico y debe ser usada de rutina para el manejo de pacientes oncológicos.
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- 2018
237. Carboplatino asociado a quimioterapia secuencial neoadyuvante en cáncer de mama triple negativo Hospital Nacional Alberto Sabogal Sologuren
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Leiva Gálvez, Manuel Humberto and Benites Zapata, Vicente
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Terapia neoadyuvante ,Neoplasias de la mama ,Carboplatino ,Quimioterapia - Abstract
Objetivo: Evaluar la respuesta patológica (RP) con quimioterapia neoadyuvante (QTN) secuencial y QTN secuencial con carboplatino (Cbp) en cáncer de mama triple negativo (CMTN), del Hospital Nacional Alberto Sabogal Sologuren (HNASS) en 2014-2015 Metodología: Estudio no experimental, analítico, longitudinal, de cohorte retrospectivo. Se estudiaron a mujeres con CMTN que tuvieron QTN en el HNASS durante 2014 y 2015. Resultados: Evaluamos 39 pacientes, 16 con QTN clásica y 13 con QTN asociada a Cbp. Edad media de 50.68 años, tamaño tumoral de 41mm, histología ductal infiltrante G2, predominio de EC IIB y IIIA, con diferencia significativa en Ki67. Respuesta patológica completa de 15%, mejores respuestas (G4-G5) 46%, sin diferencia significativa en RP global, mejor respuesta clínica ganglionar axilar en el grupo de carboplatino (p=0.008). Eventos adversos hematológicos sin diferencia significativa, suspensiones temporales y mayor uso secundario de factor estimulante de colonias (FEC) en QTN clásica. Tendencia a cirugía conservadora en QTN con Cbp, sin diferencias en RPC tras QTN con Cbp, mejor la respuesta ganglionar, mejor perfil de seguridad con FEC profiláctico. Conclusiones: En el HNASS, las pacientes con CMTN en enfermedad localmente avanzada, no muestran diferencias en RPC con QTN con Cbp, mejora la respuesta ganglionar, tienen mayor tendencia a cirugía conservadora y mejor perfil de seguridad con FEC profiláctico. Se deben de realizar ensayos clínicos de fase III multicéntricos e interinstitucionales, con esquemas de exposición temprana a platinos, o sin antraciclinas y soporte de FEC.
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- 2018
238. Efficacy of omega-3 supplementation on sertraline continuous therapy to reduce depression or anxiety symptoms: A systematic review and meta-analysis.
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Chambergo-Michilot, Diego, Brañez-Condorena, Ana, Falvy-Bockos, Ian, Pacheco-Mendoza, Josmel, and Benites-Zapata, Vicente A.
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HAMILTON Depression Inventory , *BECK Anxiety Inventory , *SERTRALINE , *BECK Depression Inventory , *ANXIETY - Abstract
• This is the first systematic review to compare the efficacy of adding omega-3 supplementation to the continuous sertraline therapy vs. not adding it. • We did not find essential reductions in depression or anxiety scales. • It may be better not to provide omega-3 supplementation to the continuous sertraline therapy in patients with coronary disease. We aimed to synthesize the evidence from randomized controlled trials (RCTs) that determined the efficacy of adding omega-3 supplementation to the continuous sertraline therapy in adults with depression. Meta-analyses were performed using random effects. We used the Revised Cochrane risk of bias tool for randomized trials version 2.0. to assess the risk of bias. Four RCTs were included. The follow-up ranged from eight to 12 weeks. Regarding the Beck Depression Inventory, the pooled SMD was 0.50 (95% CI: -0.51, 1.50; I2: 94.1%). A subgroup analysis was performed regarding the presence of coronary disease: SMD -0.17 (95% CI: -0.41, 0.07; I2: 0.0%). Regarding the Beck Anxiety Inventory, the pooled MD was 0.03 (95% CI: -2.22, 2.28; I2: 0.0%). Regarding the Hamilton Depression Rating Scale, the pooled MD was 0.42 (95% CI: -1.44, 2.29; I2: 35.7%). All pooled outcomes presented a very low certainty of the evidence. Three RCTs presented a low risk of bias in all domains; however, one study presented some concerns in two domains. No essential reductions in the outcomes were found. A subgroup analysis suggested that may be better not to provide the supplementation in patients with coronary disease. The evidence is not enough to make recommendations. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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239. Índice de masa corporal el estado inflamatorio y marcadores para valorar el estado férrico en consumidores de hierro hemo en una población de Lima Metropolitana 2017
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Maceda Kuljich, Mirko and Benites Zapata, Vicente
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Sobrepeso ,Proteína C-Reactiva ,Índice de masa corporal ,Deficiencia de hierro - Abstract
El sobrepeso, la obesidad y la deficiencia de hierro son trastornos nutricionales comunes en diferentes poblaciones. Ambas condiciones representan problemas de salud pública. El estado de inflamación subclínico en la obesidad alteraría el metabolismo de hierro; sin embargo, los hallazgos en diferentes poblaciones no son concluyentes. Objetivo: Este estudio busca determinar si el IMC en adultos está relacionado con la inflamación y a cambios en los marcadores para valorar el estado Férrico. Métodos: Estudio tipo cuantitativo, analítico, observacional, retrospectivo y transversal con diseño correlacional. Se incluyeron 70 adultos de ambos géneros entre 19 y 76 años de edad. Se evalúo peso, talla, circunferencia abdominal, dieta, antecedentes patológicos, PCR, hemoglobina y ferritina. Resultados: Se encontró una correlación positiva entre los valores de ferritina y hemoglobina, índice de masa corporal y perímetro de cintura. La media del índice de masa corporal fue mayor en el grupo con PCR positivo. La diferencia de medias del perímetro de cintura no fue estadísticamente significativa entre los grupos con PCR positivo y negativo. Usando el test exacto de fisher se encontró asociación entre tener un perímetro de cintura mayor a 100 cm y el tener un valor de hemoglobina menor a la media de la muestra; p
- Published
- 2017
240. Rendimiento del test de alteración de memoria para detectar deterioro cognitivo leve y enfermedad de alzhéimer en estadios iniciales en población de bajo nivel de instrucción de dos distritos de Lima
- Author
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Custodio Capuñay, Nilton Santos and Benites Zapata, Vicente Aleixandre
- Subjects
Enfermedad de Alzheimer ,Educación ,Demencia ,Diagnóstico diferencial - Abstract
El objetivo del presente estudio fue evaluar el rendimiento del test de alteración de la memoria (T@M) en individuos con bajo nivel de instrucción para discriminar entre pacientes con enfermedad de alzhéimer (EA), deterioro cognitivo leve amnésico (DCLa) y sujetos con estado cognitivo sano (ECS). La validez discriminativa fue evaluada en una muestra de 81 pacientes con EA; 45, con DCLa y 121 sujetos con ECS. La evaluación clínica, funcional y cognitiva fue realizada en forma independiente y en ciego y el estándar de oro del diagnóstico fue establecido por consenso basado en dichos resultados. El rendimiento del T@M fue evaluado por el análisis de las curvas del receiver operating characteristics, así como mediante el reporte del área bajo la curva (ABC). Se encontró que el puntaje promedio del T@M fue de 17,5 (DE=4,7) en EA, 30,5 (DE=2,5) en DCLa y 41,9 (DE=2,7) en ECS. Un punto de corte de 35 puntos tuvo una sensibilidad de 99,2% y una especificidad de 91,1% para diferenciar DCLa de ECS (ABC=0,956). Un punto de corte de 26 puntos tuvo una sensibilidad de 100% y una especificidad de 97,5% para diferenciar EA en estadios iniciales de DCLa (ABC=0,9960). En conclusión, el T@M tiene un alto rendimiento en la discriminación entre EA en estadios iniciales, DCLa y ECS.
- Published
- 2016
241. Efectividad del crosslinking para el tratamiento de la ectasia corneal secundaria a cirugía refractiva keratomileusis intraestromal asistida con láser
- Author
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Delgado Montes de Oca, Maybeé Elízabeth and Benites Zapata, Vicente Aleixandre
- Subjects
617.9 - Cirugía operatoria y campos especiales de la cirugía ,Cirugía láser de córnea/efectos adversos ,Pérdida de células endoteliales de la córnea ,Errores de refracción - Abstract
Comprueba la efectividad del crosslinking en el tratamiento de la ectasia corneal secundaria a cirugía refractiva. Método: Estudio descriptivo, cuantitativo, observacional, retrospectivo y de cohorte única en 15 ojos con ectasia corneal secundaria a Keratomileusis in situ asistida por láser (LASIK), se estudió la queratometría, paquimetría y eje del cilindro corneal pre y post-Crosslinking. Los cambios en las tres variables se compararon con la prueba de Wilcoxon, analizados con el paquete estadístico SPSS versión 20.0. Resultados: La reducción en la queratometría posterior al crosslinking fue 1,69 ±0,99 Dp (p0.05). El eje del cilindro corneal no presentó cambios significativos en el postoperatorio, la media fue 4,6 ±2,64 grados al tercer mes y 3,93 ±2,31 al año de la cirugía, ambos valores estadísticamente no significativos. Conclusiones: El tratamiento con crosslinking es una alternativa efectiva para detener la progresión de la ectasia corneal secundaria a cirugía refractiva, se logra que dentro del primer año postoperatorio la curvatura corneal se reduzca con estabilización de la queratometría; el adelgazamiento corneal medido con la paquimetría se detiene y finalmente el eje del astigmatismo permanece estable.
- Published
- 2015
242. Exámenes estructurales y funcionales en el glaucoma avanzado
- Author
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Dios Alemán, Juan Alberto, Alfaro Fernández, Paul Rubén, and Benites Zapata, Vicente Aleixandre
- Subjects
Tomografía de coherencia óptica ,617.7 - Oftalmología ,Pruebas del campo visual ,Glaucoma - Abstract
Determina la correlación entre los exámenes estructurales y los funcionales en pacientes con glaucoma avanzado. Método: Estudio cuantitativo, observacional, transversal en 169 pacientes con glaucoma, divididos en dos grupos: moderado y avanzado. Se midió la relación entre un examen estructural (tomógrafo de coherencia óptica Spectralis: OCT) con un funcional (campo visual Octopus: CV) en ambos grupos, usando el coeficiente de correlación de Pearson. Resultados: La desviación media en el CV fue de 8,68 ± 1,54 decibeles en glaucoma moderado, y de 17,57 ± 4,55 decibeles en avanzado; la media de la pérdida de la capa de fibras nerviosas (CFN) en el OCT fue de 94,69 ± 20,10 micras y de 69,08 ± 21,62 micras en glaucoma moderado y avanzado respectivamente. Existe correlación r = -0,493 (p < 0,05) entre OCT y CV en glaucoma moderado; pero en glaucoma avanzado no existe correlación r = -0,143 (p = 1,46), excepto entre los cuadrantes nasales del CV con los temporales del OCT r = -0,219 (p < 0,05). Conclusiones: En glaucoma avanzado no existe correlación entre la desviación media del defecto del CV y el promedio de la CFN (OCT). En estos pacientes se recomienda guiarnos por los resultados del CV. Sin embargo la CFN en los sectores temporales sí guarda correlación con el defecto equivalente del CV y puede ser de mucha utilidad para su diagnóstico y seguimiento.
- Published
- 2015
243. Efficacy and safety of visnadine in the treatment of symptoms of sexual dysfunction in heterosexual women: a systematic review of randomized clinical trials.
- Author
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Caira-Chuquineyra B, Fernandez-Guzmán D, Garayar-Peceros H, Benites-Zapata VA, Pérez-López FR, Blümel JE, and Mezones-Holguín E
- Subjects
- Humans, Female, Sexual Dysfunctions, Psychological drug therapy, Treatment Outcome, Randomized Controlled Trials as Topic, Sexual Dysfunction, Physiological drug therapy, Heterosexuality
- Abstract
Objective: To synthesize the primary evidence on the efficacy and safety of visnadine on symptoms of sexual dysfunction (SD) in heterosexual women., Methods: We conducted a systematic review of randomized clinical trials (RCTs) with a primary search without language restriction in PubMed/Medline, Scopus, Embase, Web of Science, Cochrane Library, and international clinical trial registries. Trials reporting the use of visnadine by any route in women with SD were eligible. We performed screening, data extraction, and risk of bias assessment in a double-blind approach. The primary outcomes were the Female Sexual Function Index (FSFI) and its domains. Secondary outcomes were safety, arousal, lubrication, pleasure, orgasm, negative sensations, duration, and overall satisfaction., Results: Initially, 242 records were retrieved. We selected nine papers for full-text reading and finally included two RCTs: one with a parallel design and one with a crossover design with a total of 96 patients. One study compared visnadine aerosol with a placebo, while the other compared different frequencies of visnadine aerosol use. Visnadine use showed a statistically significant improvement ( p < 0.05) in overall FSFI scores, regardless of the frequency of use. A meta-analysis was not possible due to the high clinical and methodological heterogeneity between available studies., Conclusion: RCTs regarding the use of visnadine for the Female SD are scarce and methodologically limited. This preliminary evidence shows visnadine as a potentially effective and safe option to alleviate some of the clinical symptoms of SD in heterosexual women. However, future better-designed randomized studies with larger sample numbers are required.
- Published
- 2024
- Full Text
- View/download PDF
244. Asprosin levels in patients with type 2 diabetes mellitus, metabolic syndrome and obesity: A systematic review and meta-analysis.
- Author
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Ulloque-Badaracco JR, Al-Kassab-Córdova A, Hernandez-Bustamante EA, Alarcon-Braga EA, Robles-Valcarcel P, Huayta-Cortez MA, Cabrera Guzmán JC, Seminario-Amez RA, and Benites-Zapata VA
- Subjects
- Humans, Biomarkers blood, Diabetes Mellitus, Type 2 blood, Fibrillin-1, Metabolic Syndrome blood, Obesity blood, Adipokines blood
- Abstract
Background & Aims: Asprosin is a promising candidate for novel treatments for metabolic-endocrine disorders. The objective of this systematic review and meta-analysis was to consolidate the existing evidence regarding asprosin levels in patients diagnosed with type 2 diabetes (T2D), metabolic syndrome (MetS), and obesity., Methods: Scopus, Embase, PubMed, Ovid/Medline, and Web of Science were systematically searched without restrictions. We only used the standardized mean differences (SMD) with their 95 % confidence intervals (95 % CI) as the effect measure. A random-effects model (DerSimonian and Laird method) was used for the meta-analysis. Risk of bias was assessed with the Newcastle-Ottawa Scale and Newcastle-Ottawa Scale for Cross-Sectional Studies., Results: Twenty-six studies (n = 3,787) were included in the meta-analysis. Participants with T2D had higher asprosin values than those without T2D (SMD: 1.64; 95 % CI: 1.08-2.21; I
2 = 97 %). Patients with MetS had higher asprosin levels compared to those without MetS (SMD: 0.99; 95 % CI: 0.34-1.64; I2 = 96 %). Patients with obesity had higher asprosin levels than participants without obesity (SMD: 1.49; 95 % CI: 0.23-2.76; I2 = 98 %)., Conclusions: Asprosin is significantly higher in patients with either T2D, MetS, or obesity, compared with controls., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Research Trust of DiabetesIndia (DiabetesIndia) and National Diabetes Obesity and Cholesterol Foundation (N-DOC). Published by Elsevier Ltd. All rights reserved.)- Published
- 2024
- Full Text
- View/download PDF
245. Ethnicity and refractive errors in Peruvian children aged 7-11 years: A five-year analysis of the Demographic and Health Survey.
- Author
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De-La-Borda-Prazak G, Mendez-Guerra C, Huertas-Campos F, Herrera-Añazco P, and Benites-Zapata VA
- Subjects
- Humans, Male, Child, Female, Cross-Sectional Studies, Peru epidemiology, Peru ethnology, Prevalence, Refractive Errors epidemiology, Refractive Errors ethnology, Health Surveys, Ethnicity statistics & numerical data
- Abstract
Objective: To assess the association between ethnicity and self-reported refractive errors (REs) among Peruvian children aged 7-11 years., Materials and Methods: We conducted a cross-sectional study incorporating a secondary data analysis of 2017-2021 data from the Peruvian Demographic and Health Survey (DHS). REs and ethnicity were obtained from focal child's mother's report. Four outcomes were assessed: hyperopia, myopia, astigmatism and any RE. We included potential confounders, such as age, sex, wealth index, area of residence, region of origin, frequency of watching TV and watching screens at less than 30 cm distance. Generalised linear models with the Poisson family and log link function were used to calculate crude prevalence ratio and adjusted prevalence ratio (aPR) with 95% confidence intervals (95% CI)., Results: Data from a total of 52,753 children were included. The prevalence of RE in children aged 7-11 years was 10.90% (95% CI 10.49-11.33), of which 5.19% were hyperopia, 3.35% myopia and 2.36% astigmatism. Those of the Aymara ethnicity were less likely to suffer from any RE and astigmatism (aPR = 0.68, 95% CI 0.46-0.99, p = 0.046; aPR = 0.70, 95% CI 0.53-0.92, p = 0.012, respectively), Members of Amazon groups were more likely to have hyperopia (aPR = 1.95, 95% CI 1.14-3.36, p = 0.015) and Quechuas were more likely to have myopia (aPR =1.29, 95% CI 1.02-1.62, p = 0.028), where all were compared to Mestizos., Conclusion: About 1 in 10 Peruvian children suffer from a RE. The most frequent RE in this study was hyperopia. Ethnic differences were seen in the frequency of RE., Competing Interests: Conflicts of interest None of the authors have any proprietary interests or conflicts of interest related to this submission., (Copyright © 2023. Published by Elsevier España, S.L.U.)
- Published
- 2024
- Full Text
- View/download PDF
246. Mpox infection in animals: A systematic review and meta-analysis.
- Author
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Bonilla-Aldana DK, Bonilla-Aldana JL, Ulloque-Badaracco JR, Al-Kassab-Córdova A, Hernandez-Bustamante EA, Alarcon-Braga EA, Benites-Zapata VA, Copaja-Corzo C, Silva-Cajaleon K, and Rodriguez-Morales AJ
- Subjects
- Animals, Prevalence, Rodentia, Humans, Shrews, Primates, Zoonoses epidemiology, Mpox (monkeypox) epidemiology
- Abstract
Mpox is a zoonotic disease that became epidemic in multiple countries in 2022. There is a lack of published systematic reviews on natural animal infection due to Mpox. We performed a systematic literature review with meta-analysis to assess animal Mpox prevalence. We performed a random-effects model meta-analysis to calculate the pooled prevalence and 95% confidence interval (95%CI) for prevalence studies. After the screening, 15 reports were selected for full-text assessment and included in qualitative and quantitative analyses. Ten reports assessed Mpox infection by molecular or serological tests (n = 2680), yielding a pooled prevalence of 16.0% (95%CI: 3.0-29.0%) for non-human primates; 8.0% (95%CI: 4.0-12.0%) for rodents and 1.0% (95%CI: 0.0-3.0%) for shrews. Further studies in other animals are required to define the extent and importance of natural infection due to Mpox. These findings have implications for public human and animal health. OneHealth approach is critical for prevention and control., Competing Interests: Declaration of Competing Interest All authors report no potential conflicts. Declaration of competing interest All authors report no potential conflicts., (Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF
247. Serological and molecular detection of dengue virus in animals: A systematic review and meta-analysis.
- Author
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Bonilla-Aldana DK, Rodas-Fuenmayor MM, Ruiz-Aristizabal LM, Ulloque-Badaracco JR, Alarcón-Braga EA, Hernandez-Bustamante EA, Cabrera-Guzman JC, Ulloque-Badaracco RR, Benites-Zapata VA, and Rodriguez-Morales AJ
- Abstract
Introduction: Dengue is a vector-borne disease, especially important in tropical and subtropical areas. The first presentation of many arboviral diseases occurred mainly in animals, including multiple Alphaviruses and Flaviviruses , such as dengue., Objective: To determine the serological and molecular frequency of the dengue virus in animals., Methods: A systematic literature review was carried out in five databases for the proportion of animals infected with dengue, defined by molecular and serological tests. A meta-analysis was performed using a random-effects model to calculate the pooled prevalence and 95% confidence intervals (CI). Cochran?s Q test and the I2 statistic were used to assess the heterogeneity between the two studies., Results: The presence of dengue in bats, primates, birds, sheep, horses, cattle, pigs, rodents and buffaloes, according to serological methods, had a prevalence of 10%, 29%, 8%, 1%, 11%, 0%, 49%, 2%, 7%, respectively. According to molecular methods, the presence of dengue in bats had a seroprevalence of 6.0%., Conclusion: The present study confirms the presence of the Dengue virus in a large group of animal species, with potential implications as possible reservoirs of this virus, raising the possibility of zoonotic transmission., Competing Interests: Conflict of interest: None.
- Published
- 2024
- Full Text
- View/download PDF
248. Association of vitamin B12, folate, and homocysteine with COVID-19 severity and mortality: A systematic review and meta-analysis.
- Author
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Ulloque-Badaracco JR, Al-Kassab-Córdova A, Alarcon-Braga EA, Hernandez-Bustamante EA, Huayta-Cortez MA, Cabrera-Guzmán JC, Robles-Valcarcel P, and Benites-Zapata VA
- Abstract
Objective: We aimed to review the available evidence on the association between vitamin B12, folate, and homocysteine levels with worse outcomes among COVID-19 patients., Methods: The search was carried out in ten databases simultaneously run on 10 May 2023, without language restrictions. We included cross-sectional, case-control, and cohort studies. The random-effects meta-analysis was performed using the Sidik-Jonkman method and corrected 95% confidence intervals using the truncated Knapp-Hartung standard errors. Standardized mean difference and 95% CI was used as the measure effect size., Results: Thirteen articles were included in this review ( n = 2134). Patients with COVID-19 who did not survive had the highest serum vitamin B12 values (SMD: 1.05; 95% CI: 0.31-1.78; p = 0.01, I
2 = 91.22%). In contrast, low serum folate values were associated with patients with severe COVID-19 (SMD: -0.77; 95% CI: -1.35 to -0.19; p = 0.02, I2 = 59.09%). The remaining tested differences did not yield significant results., Conclusion: Elevated serum levels of vitamin B12 were associated with higher mortality in patients with COVID-19. Severe cases of COVID-19 were associated with low serum folate levels. Future studies should incorporate a larger sample size., Competing Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article., (© The Author(s) 2024.)- Published
- 2024
- Full Text
- View/download PDF
249. Fungal infections in patients after recovering from COVID-19: a systematic review.
- Author
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Ulloque-Badaracco JR, Copaja-Corzo C, Hernandez-Bustamante EA, Cabrera-Guzmán JC, Huayta-Cortez MA, Carballo-Tello XL, Seminario-Amez RA, Hueda-Zavaleta M, and Benites-Zapata VA
- Abstract
Background and Aims: The presence of fungal infections has been described in patients after recovering from COVID-19. This study aims to conduct a systematic review of studies that reported fungal infections ( Mucor spp., Pneumocystis jirovecii , or Aspergillus spp.) in adults after recovering from COVID-19., Methods: We performed a systematic review through PubMed, Web of Science, OVID-Medline, Embase, and Scopus. The study selection process was performed independently and by at least two authors. We performed a risk of bias assessment using the Newcastle-Ottawa Scale for cohort and case-control studies, and the Joanna Briggs Institute's Checklists for Case Series and Case Reports., Results: The systematic search found 33 studies meeting all inclusion criteria. There was a total population of 774 participants, ranging from 21 to 87 years. From them, 746 developed a fungal infection. In 19 studies, Mucor spp. was reported as the main mycosis. In 10 studies, P. jirovecii was reported as the main mycosis. In seven studies, Aspergillus spp. was reported as the main mycosis. Regarding the quality assessment, 12 studies were classified as low risk of bias and the remaining studies as high risk of bias., Conclusion: Patients' clinical presentation and prognosis after recovering from COVID-19 with fungal infection differ from those reported patients with acute COVID-19 infection and those without COVID-19 infection., Competing Interests: The authors declare that there is no conflict of interest., (© The Author(s), 2024.)
- Published
- 2024
- Full Text
- View/download PDF
250. Snakebite-Associated Infections: A Systematic Review and Meta-Analysis.
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Bonilla-Aldana DK, Bonilla-Aldana JL, Ulloque-Badaracco JR, Al-Kassab-Córdova A, Hernandez-Bustamante EA, Alarcon-Braga EA, Siddiq A, Benites-Zapata VA, Rodriguez-Morales AJ, Luna C, and Suarez JA
- Subjects
- Humans, Prevalence, Animals, Anti-Bacterial Agents therapeutic use, Asia epidemiology, Snake Bites epidemiology, Snake Bites complications
- Abstract
Snakebites still constitute a significant public health problem in developing countries and are considered a neglected tropical condition by the WHO. Snake accidents are associated with substantial morbidity and mortality and may produce secondary complications, such as severe infections. The objective of this systematic review was to determine the prevalence of snakebite infections and characterize the bacteria isolated from these infections. A systematic literature review in five databases was carried out to assess the prevalence of snakebite infection. A meta-analysis was performed using a random-effects model to calculate the pooled prevalence and 95% CIs. Cochran's Q test and the I2 statistic were used to assess between-study heterogeneity. The pooled prevalence of infection due to snakebite was 27.0% (95% CI: 22.0-32.0%), with high heterogeneity among studies (I2 = 99.7%). The prevalence was higher in Asia (32%) than in the Americas (21%). Snakebite infections required surgical interventions in 68% (95% CI: 37.0-98.0%). The leading group of pathogens identified corresponded to Gram-negative bacteria (63%), particularly Morganella morganii (32%), but also, Gram-positive cocci (40%), especially Enterococcus spp. (23%) and Staphylococcus aureus (15%). However, multiple other pathogens, including anaerobes, were found. A high prevalence of snakebite-associated infection has been described, primarily due to M. morganii, with the corresponding implications for empirical therapy. Rational use of antimicrobials is recommended, and this should guide initial empirical treatment. Moreover, isolation and identification of the possible bacteria present in snakebite wounds is recommended in all cases to confirm or rule out associated infection.
- Published
- 2024
- Full Text
- View/download PDF
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