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201. Ascorbate biosynthesis in mitochondria is linked to the electron transport chain between complexes III and IV.

Author

Bartoli, C G, Pastori, G M, and Foyer, C H

Abstract

Ascorbic acid is synthesized from galactono-gamma-lactone (GL) in plant tissues. An improved extraction procedure involving ammonium sulfate precipitation of membrane proteins from crude leaf homogenates yielded a simple, quick method for determining tissue activities of galactono-gamma-lactone dehydrogenase (GLDH). Total foliar ascorbate and GLDH activity decreased with leaf age. Subcellular fractionation experiments using marker enzymes demonstrated that 80% of the total GLDH activity was located on the inner mitochondrial membrane, and 20% in the microsomal fraction. Specific antibody raised against potato (Solanum tuberosum L.) tuber GLDH recognized a 56-kD polypeptide in extracts from the mitochondrial membranes but failed to detect the equivalent polypeptide in microsomes. We demonstrate that isolated intact mitochondria synthesize ascorbate in the presence of GL. GL stimulated mitochondrial electron transport rates. The respiration inhibitor antimycin A stimulated ascorbate biosynthesis, while cyanide inhibited both respiration and ascorbate production. GL-dependent oxygen uptake was observed in isolated intact mitochondria. This evidence suggests that GLDH delivers electrons to the mitochondrial electron transport chain between complexes III and IV.

Published
2000
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202. A comparison of the activity of a heparan sulphate of defined molecular weight range (7500-15 000 Da) with heparin and dermatan sulphate

Author

Gervasi, G.B., Catalani, R., Bartoli, C., Carpita, G., Farina, C., and Gelso, E.

Abstract

The fibrinolytic and anticoagulant activities of heparan sulphate (HS) and dermatan sulphate (DS) were compared with those of heparin using in vitro tests. Our results demonstrate that HS has higher profibrinolytic activity than heparin and DS. Although 50 times less potent than heparin in inhibiting factor IIa, HS is three times more active than DS. The action of HS resides in HCII-mediated factor IIa inhibition combined with an ATIII-mediated inhibition. DS has no action on ATIII-mediated inhibition of factor IIa. The comparison of the anticoagulant activities of the, three compounds confirmed the very limited anticoagulant effect of both HS and DS in comparison with heparin.

Published
1995
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207. Flip instability of plasma in the theta pinch

Author

Bartoli, C. and Green, T. S.

Abstract

Recent experiments on the behaviour of plasma in the theta pinch have shown that, although the plasma in reversed-field discharges is normally unstable, there are some cases in which the plasma is stable and contained. The present paper considers the following hypothesis: (a) that the mode of instability commonly encountered is that observed by Clark and Wuerker (in which the axis of the magnetic moment of the current supporting the trapped reversed field appears to rotate from its initial state of alignment with the field axis) and (b) that there exists a class of configurations of the plasma enclosed by the field lines that are stable against this rotation of the plasma axis.

Published
1963
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208. Effetti farmacologici di un composto di natura peptidica sul microcircolo retinico del coniglio: osservazioni fluorangiografiche

Author

Ammannati P., Siravo D., Bartoli C., Carpita G., Gervasi G.B., and Azzarelli L.

Subjects
Life and medical sciences, Medical information systems
Abstract

In questi ultimi anni è stata sottolineata l'importanza della fuoriuscita a livello perivasale dell'albumina glicosilata come un elemento patogenetico nei danni retinici dei pazienti diabetici. Le ricerche in questo campo hanno evidenziato che le caratteristiche chimico-fisiche dell'albumina glicosilata permettono a tale sostanza di superare facilmente la parete vasale e di diffondersi nel tessuto extravasale in quantità molto maggiore rispetto all'albumina stessa. Tale sostanza ha pertanto acquisito una notevole importanza come «tool» farmacologico per lo studio di farmaci che possono in qualche modo modificare o riparare i danni indotti da focolai emorragici retinici e dall'edema conseguente la fuoriuscita di plasma dal microcircolo. Per questo studio è stato utilizzato un composto a base di peptidi derivanti dall'idrolisi enzimatica del fattore VIII bovino (VUEFFE - Laboratori Baldacci - Pisa).

Published
1989

210. The role of magnetic resonance imaging in the evaluation of neoplastic lesions of the breast

Author

Bargellini A, E. Ceglia, Renato Musumeci, Coopmans de Yoldi G, R. Petrillo, John David Tesoro Tess, Bartoli C, Luca Balzarini, and Greco M

Subjects
Alternative methods, Cancer Research, medicine.medical_specialty, medicine.diagnostic_test, business.industry, Magnetic resonance imaging, Breast Neoplasms, General Medicine, Breast pathology, Magnetic Resonance Imaging, Suspected breast cancer, Fine-needle aspiration, Oncology, Biopsy, medicine, Mammography, Humans, Female, Radiology, Ultrasonography, business
Abstract

Thirty-seven patients were evaluated for suspected breast cancer by magnetic resonance imaging (MRI) using 0.5- and 1.5-Tesla. We esamined the patterns in breast images and the use of MRI in evaluating neoplasms. At the moment the cost/benefit ratio is unfavorable, mainly because of the availability of alternative methods of high accuracy and low cost, like mammography and ultrasonography. Furthermore fine needle aspiration biopsy is not possible with MRI. The widespread use of MRI for breast pathology seems not to be justified by the results obtained.

Published
1989

211. [Distant metastases from thyroid carcinomas]

Author

Bartoli C, Turri M, and Natale Cascinelli

Subjects
Oncology, Male, Cancer Research, medicine.medical_specialty, Lung Neoplasms, Statistics as Topic, Bone Neoplasms, 030218 nuclear medicine & medical imaging, Thyroid carcinoma, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, In patient, Thyroid Neoplasms, Neoplasm Metastasis, Aged, business.industry, Cancer, General Medicine, Middle Aged, medicine.disease, 030220 oncology & carcinogenesis, Female, business
Abstract

From 1928 to 1965, 383 cases of thyroid carcinoma were studied at the National Cancer Institute of Milan; among these cases 113 had distant metastases. The metastases were more frequent in patients aged fro 60 to 69. The female/male ratio was about 2:1. The lesions were more often in the skeleton (74 cases) and in the lungs (64 cases). Since a high incidence of skeletal metastases without lung involvement has been observed, the authors postulate that metastatic spread from thyroid carcinoma may occur also through vertebral veins. In undifferentiated carcinomas distant metastases occur quite early (87 % at 5 years). On the contrary, in differentiated carcinomas, metastases occur later: after 5 years from thyroidectomy in 31 per cent of patients with follicular carcinomas metastases were found and in 74 per cent after 10 years. In papillary carcinomas the percentage is 17 and 52 after 5 and 10 years respectively. Among 113 cases with distant metastases, 50 showed the first metastatic localization to the regional lymph nodes; this occurrence was found to be more frequent in papillary and unidifferentiated carcinomas (χ2 = 11.805).

Published
1967

217. [Mammography in the diagnosis of phyllodes tumors of the breast. Analysis of 99 cases]

Author

Cosmacini, P., PAOLO VERONESI, STEFANO ZURRIDA, Bartoli, C., Ferranti, C., and G Coopmans De Yoldi

Subjects
Phyllodes Tumor, Humans, Breast Neoplasms, Female, Middle Aged, Mammography, Retrospective Studies
Abstract

The clinical history of the phyllodes tumor and its rather complex histologic patterns, ranging from benignity to malignity, often make both preoperative diagnostic procedures and the therapeutic approach very difficult to apply strictly. We reviewed the mammographic examinations of 99 patients observed and treated at the Istituto Nazionale Tumori of Milan, 1975 to 1989, looking for a mammographic-histologic correlation useful for both an unquestionable and early diagnosis and adequate excision. Many parameters were considered for each histologic type of phyllodes tumor (65 benign, 20 borderline, and 14 malignant), such as opacity, size, shape and borders of the tumor, presence/absence of calcifications inside, and radiolucent halo. The lesion was evident in all 3 projections in 85 cases (85.5%). Tumor contour was rounded in 45 instances and polycyclic in 54. Margins were distinct or mostly distinct in 81 instances (81.8%), indistinct in 11 (11.1%), and irregular in 7 (7%). The radiolucent halo was complete in 11 cases (11.1%), incomplete in 50 (50.5%), and absent in 38 (38.4%). In our experience, the most useful and characterizing mammographic parameters were tumoral borders and opacity.

219. SCCA2-like serpins mediate genetic predisposition to skin tumors

Author

Gariboldi, M., Peissel, B., Fabbri, A., Anna Saran, Zaffaroni, D., Stefania Falvella, F., Spinola, M., Tanuma, J. -I, Pazzaglia, S., Mancuso, M. T., Maurichi, A., Bartoli, C., Cataltepe, S., Silverman, G. A., Pilotti, S., Hayashizaki, Y., Okazaki, Y., and Dragani, T. A.

227. A Phase-II study of mitoxantrone combined with beta-interferon in unresectable hepatocellular carcinoma

Author

Colleoni, M., Buzzoni, R., Bajetta, E., Bochicchio, A.M., Bartoli, C., Audisio, R., Bonfanti, G., and Nole, F.

Subjects
Liver cancer, Mitoxantrone hydrochloride -- Evaluation, Interferon beta -- Health aspects, Business, Health care industry
Abstract

SOURCE: Cancer, December 1, 1993;72(11):3196-3201. According to the authors' abstract of an article published in Cancer, 'Background: Chemoimmunotherapy is being evaluated in the most common gastrointestinal tumors, but little data [...]

Published
1994

235. Electric propulsion in Europe

Author

Bartoli, C., primary, Loeb, H.W., additional, Bassner, H., additional, Valentian, D., additional, Baiocchi, G., additional, Atzei, A., additional, von Rohden, H., additional, Trippi, A., additional, Schrade, H.O., additional, Andrenucci, M., additional, and Igenbergs, E., additional

Published
1986
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241. Sunti delle comunicazioni presentate al XLVII Congresso della società

Author

Abate, E., primary, Bellini, G., additional, Fiorini, E., additional, Ratti, S., additional, Abbattista, N., additional, Minafra, A., additional, Mongelli, S., additional, Romano, A., additional, Waloschek, P., additional, Ageno, M., additional, Felici, C., additional, Agodi, A., additional, Giordano, R., additional, Alitti, J., additional, Alles-Borelli, V., additional, Baton, J. P., additional, Berthelot, A., additional, Bidan, U., additional, Daudin, A., additional, Deler, B., additional, Goussu, O., additional, Jabiol, M. A., additional, Lévy, F., additional, Lewin, C., additional, Neveu-René, M., additional, Rogozinski, A., additional, Shively, F., additional, Laberrigue-Frolow, J., additional, Ouannès, O., additional, Sené, M., additional, Vigneron, L., additional, Benedetti, E., additional, Litvak, J., additional, Puppi, G., additional, Whitehead, M., additional, Allen, J. E., additional, Bartoli, C., additional, Brunelli, B., additional, Nation, J. A., additional, Rumi, B., additional, Toschi, R., additional, Boschi, A., additional, Magistrelli, F., additional, Allen, J. B., additional, Coville, C., additional, Martone, M. U., additional, Segre, S. E., additional, Amaldi, U., additional, Cocconi, V. T., additional, Fazzini, T., additional, Fidecaro, G., additional, Gesquière, C., additional, Legros, M., additional, Steiner, H., additional, Andreassi, G., additional, Budini, P., additional, Calucci, G., additional, Furlan, G., additional, Peressutti, G., additional, Cazzola, P., additional, Archetti, I., additional, Bocciarelli, D. Steve, additional, Argan, P. E., additional, Bendiscioli, G., additional, Ciocchetti, G., additional, Ferrero, I., additional, Gigli, A., additional, Piazzoli, A., additional, Picasso, E., additional, Piragino, G., additional, Ascarelli, G., additional, Rodriguez, S., additional, Ascenzi, A., additional, Bonucci, E., additional, François, C., additional, Ascoli, A., additional, Fuhrman, Z. A., additional, Ascoli-Bartoli, U., additional, De Angelis, A., additional, Martellucci, S., additional, Asdente, M., additional, Friedel, J., additional, Aubert, B., additional, Brisson, V., additional, Hennessy, J., additional, Mittner, P., additional, Six, J., additional, Baglin, C., additional, Bloch, M., additional, Bressy, A., additional, Lagarrigue, A., additional, Orkin-Lecourtois, A., additional, Rançon, P., additional, Rousset, A., additional, Sauteron, X., additional, Auer, P. L., additional, Aurisicchio, S., additional, Frontali, C., additional, Graziosi, F., additional, Toschi, G., additional, Bachelet, F., additional, Balata, P., additional, Lucci, N., additional, Baldassarre, F., additional, Caforio, A., additional, Ferilli, A., additional, Ferraro, D., additional, Merlin, M., additional, Semeraro, S., additional, Fisher, C. M., additional, Gibson, W. M., additional, Mason, A., additional, Venus, W., additional, Evans, D., additional, Hossain, A., additional, Lock, W. O., additional, Votruba, M. F., additional, Wataghin, A., additional, Kasim, M. M., additional, Shaukat, M. A., additional, Fedrighini, A., additional, Herz, A. J., additional, Sichirollo, A. E., additional, Tallone, L., additional, Vegni, G., additional, Balzarotti, A., additional, Chiarotti, G., additional, Frova, A., additional, Baracchi, F., additional, Perilli-Fedeli, R., additional, Pierucci, M., additional, Saltini, G., additional, Barbiellini, G., additional, Bologna, G., additional, Diambrini, G., additional, Murtas, G. P., additional, Barone, A., additional, Baroni, G., additional, Bizzarri, R., additional, Guidoni, P., additional, Manfredini, A., additional, Stajano, A., additional, Brautti, G., additional, Ceschia, M., additional, Chersovani, L., additional, Sessa, M., additional, Bassetti, M., additional, Pompei, A., additional, Bassi, P., additional, Bertolini, G., additional, Cappellani, F., additional, Ferretti, B., additional, Restelli, G. B., additional, Rota, A., additional, Venturini, G., additional, Battaglia, A., additional, Iannuzzi, M., additional, Polacco, E., additional, Antoni, G. Degli, additional, Negri, P., additional, Fretter, W. B., additional, Hoang, T. F., additional, Bingham, H., additional, Drijard, D., additional, De Raad, B., additional, Salmeron, R., additional, Voss, R., additional, Cresti, M., additional, Limentani, S., additional, Santangelo, R., additional, Boreani, G., additional, Perrero, I., additional, Garelli, C. M., additional, Lagar-Rigue, A., additional, Beltrametti, E. G., additional, Beltrami, M., additional, Colombo, M., additional, Fieschi, R., additional, Berkelman, K., additional, Cortellessa, G., additional, Reale, A., additional, Bernè, A., additional, Boato, G., additional, De Paz, M., additional, Bertolotti, M., additional, Grasso, V., additional, Papa, T., additional, Sette, D., additional, Bertoluzza, C., additional, Bisi, A., additional, Fasana, A., additional, Gatti, E., additional, Zappa, L., additional, Casanova, G., additional, Levi, A. C., additional, Bonazzola, G., additional, Borello, O. A., additional, Costa, S., additional, Ferroni, S., additional, Bonera, G., additional, Borsa, F., additional, De Stefano, P., additional, Rigamionti, A., additional, Rigamonti, A., additional, Bordoni, P. G., additional, Giua, P. E., additional, Palmieri, L., additional, Verani-Borgucci, M., additional, Nuovo, M., additional, Verdini, L., additional, Ferrero, F., additional, Malvano, R., additional, Molinari, A., additional, Borgonovi, G., additional, Caglioti, G., additional, Ricci, F. P., additional, Santoro, A., additional, Scatturin, V., additional, Bortolani, M. V., additional, Lendinara, L., additional, Monari, L., additional, Braccesi, A., additional, Ceccarelli, M., additional, Weber, T., additional, Buttino, G., additional, Cecchetti, A., additional, Drigo, A., additional, Caianiello, E. R., additional, Marinaro, M., additional, Preziosi, B., additional, Caldirola, P., additional, De Baebieri, O., additional, Calvi, G., additional, Parisi, R., additional, Rubbino, A., additional, Camagni, P., additional, Manara, A., additional, Caimpolattaro, A., additional, Campos Venuti, G., additional, Matthiae, G., additional, Canobbio, E., additional, Cappelletti, R., additional, Dalla Croce, L., additional, Careri, G., additional, Cunsolo, S., additional, Mazzoldi, P., additional, Carrara, N., additional, Checcacci, P. F., additional, Ronchi, L., additional, Carrara, R., additional, Grigoletto, A., additional, Loria, A., additional, Peruzzo, L., additional, Venchiarutti, D., additional, Carrelli, A., additional, Grossetti, E., additional, Pauciulo, L., additional, Carreli, A., additional, Tartaglione, E., additional, Brescia, G., additional, Porreca, F., additional, Cattaneo, F., additional, Germagnoli, E., additional, Cavaliere, A., additional, Cavallaro, S., additional, Potenza, R., additional, Ricamo, R., additional, Cavalleri, G., additional, Redaelli, G., additional, Giovanellt, R., additional, Ceresara, S., additional, Federigih, T., additional, Cernigoi, C., additional, Gabrielli, I., additional, Iernetti, G., additional, Villi, C., additional, Chadwick, C. B., additional, Davies, W. T., additional, Derrick, M., additional, Mulvey, J. H., additional, Radojicic, D., additional, Wilkinson, C. A., additional, Nardelli, G., additional, Chiozzotto, A., additional, Valente, F., additional, Lipman, N. H., additional, Merrison, A. W., additional, Colli, L., additional, Bassani, G., additional, Sona, P. G., additional, Cristofori, F., additional, Franceschetti, M. O., additional, Iori, I., additional, Krzuk, G., additional, Mangialajo, M., additional, Marcelja, F., additional, Merzari, F., additional, Conforto, G., additional, Conversi, M., additional, Di Lella, L., additional, Penso, G., additional, Toller, M., additional, Rubbia, C., additional, di Lella, L., additional, Contursi, G., additional, Pozzi, A., additional, Salvadori, P., additional, Crosignani, E., additional, Franzosini, P., additional, Siragusa, G., additional, Zanotti, L., additional, Cutolo, M., additional, Cuzzocrea, P., additional, Ricci, R. A., additional, Vingiani, G. B., additional, Da Prato, G., additional, Debiasi, G. B., additional, Rostagni, G., additional, De Carvalho, H., additional, Celano, A., additional, Cortini, G., additional, Del Giudice, E., additional, Potenza, G., additional, Rinzivillo, R., additional, Ghigo, G., additional, de Carvalho, H. G., additional, Muchnik, M., additional, Severi, M., additional, Combe, J., additional, Goebel, K., additional, Manfeedini, A., additional, Vanderhaeghe, G., additional, Bösch, R., additional, Lang, J., additional, Müller, R., additional, Wölfli, W., additional, de Carvaiho, H. G., additional, Salvetti, F., additional, Sassi, E., additional, Degli Antoni, G., additional, Boella, G., additional, Cantù, C., additional, Della Valle, F., additional, Frontali, L., additional, Orlando, P., additional, Tecce, G., additional, Delli Santi, S., additional, Mannino, G., additional, Setti, G., additional, Demanins, F., additional, Pisent, G., additional, Poiani, G., additional, De Martini, F., additional, Desalvo, A., additional, Gondi, P., additional, Levi, F. A., additional, Zignani, F., additional, De Tollis, B., additional, Verganelakis, A., additional, Di Corato, M., additional, Geisema, E. S., additional, Minguzzi-Ranzi, A., additional, Belltère, J., additional, Bingham, H. H., additional, Garelli, M., additional, Vigone, M., additional, Waldner, P., additional, de Raad, B., additional, Emma, V., additional, Milone, C., additional, Iannelli, S., additional, Mezzanares, F., additional, Erra, E., additional, Saetta Menichella, E., additional, Facchini, U., additional, Erdas, F., additional, von Gehlen, G., additional, Fabri, G., additional, Fabiani, F., additional, Fidecaro, M., additional, Finocchiaro, G., additional, Giacomelli, G., additional, Harting, D., additional, Torelli, G., additional, Gatti, G., additional, Middelkoop, W. C., additional, Yamagata, T., additional, Spinolo, G., additional, Freindl, L., additional, Niewodniczański, H., additional, Nurzyński, J., additional, Slapa, M., additional, Strzalkowski, A., additional, Mangiantini, M. T., additional, Galzenati, E., additional, Pusterla, M., additional, Gasparini, F., additional, Svelto, V., additional, Tamburello, C., additional, Gellt, D., additional, Gelli, D., additional, Federighi, T., additional, Grilli, A., additional, Noblli, D., additional, Greenlees, G. W., additional, Grotowski, K. A., additional, Robbins, A. B., additional, Grimaldi, M., additional, Votruba, F. M., additional, Principi, P., additional, Rossini, T., additional, Linhart, J. G., additional, Knoepfel, H., additional, Gourlan, C., additional, Liotta, R. S., additional, Luccio, A., additional, Pavanati, G., additional, Resmini, F., additional, Rosatelli, C., additional, Succi, C., additional, Tagliaferri, G., additional, Resmimi, F., additional, Maisonnier, Ch., additional, Haegi, M., additional, Omini, M., additional, Marcazzan, M. G., additional, Tonolini, F., additional, Martelli, G., additional, Chapman, K., additional, Galbraith, W., additional, van der Raay, H. B., additional, Reading, D. H., additional, Rubinstein, R., additional, Marx, G., additional, Missiroli, G., additional, Valdrè, U., additional, Missoni, G., additional, Motz, J. W., additional, Monti, D., additional, Quareni, G., additional, Quareni Vignudelli, A., additional, Gottntein, K., additional, Püschel, W., additional, Tietge, J., additional, Morchio, R., additional, Borsellino, A., additional, Notarrigo, S., additional, Paić, M., additional, Antolković, B., additional, Tomaš, P., additional, Turk, M., additional, Paoletti, A., additional, Pappalardo, G., additional, Vinciguerra, D., additional, Pelosi, V., additional, Tomasini, G., additional, Dascola, G., additional, Gainotti, A., additional, Lamborizio, C., additional, Pratesi, R., additional, Scheggi, A. M., additional, di Francia, G. Toraldo, additional, Quercia, T. F., additional, Turrisi, E., additional, Jean, M., additional, Van Lieshout, R., additional, Monaro, S., additional, Chilosi, G., additional, Van Nooyen, B., additional, Sargentini, A., additional, Sgarlata, F., additional, Wanderlingh, F., additional, Somon, J. P., additional, Waldner, F., additional, Zin, G., additional, and Vinci, F., additional

Published
1962
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