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2,116 results on '"Baldus, Stephan"'

201. IL-1RA Antibodies in Myocarditis after SARS-CoV-2 Vaccination

Author

Thurner, Lorenz, primary, Kessel, Christoph, additional, Fadle, Natalie, additional, Regitz, Evi, additional, Seidel, Franziska, additional, Kindermann, Ingrid, additional, Lohse, Stefan, additional, Kos, Igor, additional, Tschöpe, Carsten, additional, Kheiroddin, Parastoo, additional, Kiblboeck, Daniel, additional, Hoffmann, Marie-Christin, additional, Bette, Birgit, additional, Carbon, Gabi, additional, Cetin, Onur, additional, Preuss, Klaus-Dieter, additional, Christofyllakis, Konstantinos, additional, Bittenbring, Joerg T., additional, Pickardt, Thomas, additional, Fischer, Yvan, additional, Thiele, Holger, additional, Baldus, Stephan, additional, Stangl, Karl, additional, Steiner, Stephan, additional, Gietzen, Frank, additional, Kerber, Sebastian, additional, Deneke, Thomas, additional, Jellinghaus, Stefanie, additional, Linke, Axel, additional, Ibrahim, Karim, additional, Grabmaier, Ulrich, additional, Massberg, Steffen, additional, Thilo, Christian, additional, Greulich, Simon, additional, Gawaz, Meinrad, additional, Mayatepek, Ertan, additional, Meyer-Dobkowitz, Lars, additional, Kindermann, Michael, additional, Birk, Einat, additional, Birk, Merav, additional, Lainscak, Mitja, additional, Foell, Dirk, additional, Lepper, Philipp M., additional, Bals, Robert, additional, Krawczyk, Marcin, additional, Mevorach, Dror, additional, Hasin, Tal, additional, Keren, Andre, additional, Kabesch, Michael, additional, Abdul-Khaliq, Hashim, additional, Smola, Sigrun, additional, Bewarder, Moritz, additional, Thurner, Bernhard, additional, Böhm, Michael, additional, Pfeifer, Jochen, additional, and Klingel, Karin, additional

Published
2022
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202. Optimal protamine‐to‐heparin dosing ratio for the prevention of bleeding complications in patients undergoing TAVR—A multicenter experience

Author

Al‐Kassou, Baravan, primary, Veulemans, Verena, additional, Shamekhi, Jasmin, additional, Maier, Oliver, additional, Piayda, Kerstin, additional, Zeus, Tobias, additional, Aksoy, Adem, additional, Zietzer, Andreas, additional, Meertens, Max, additional, Mauri, Victor, additional, Weber, Marcel, additional, Sinning, Jan‐Malte, additional, Grube, Eberhard, additional, Adam, Matti, additional, Bakhtiary, Farhad, additional, Zimmer, Sebastian, additional, Baldus, Stephan, additional, Kelm, Malte, additional, Nickenig, Georg, additional, and Sedaghat, Alexander, additional

Published
2022
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207. Guideline-directed medical treatment in patients undergoing transcatheter edge-to-edge repair for secondary mitral regurgitation

Author

Higuchi, Satoshi, Orban, Mathias, Adamo, Marianna, Giannini, Cristina, Melica, Bruno, Karam, Nicole, Praz, Fabien, Kalbacher, Daniel, Koell, Benedikt, Stolz, Lukas, Braun, Daniel, Näbauer, Michael, Wild, Mirjam, Doldi, Philipp, Neuss, Michael, Butter, Christian, Kassar, Mohammad, Ruf, Tobias, Petrescu, Aniela, Ludwig, Sebastian, Pfister, Roman, Iliadis, Christos, Unterhuber, Matthias, Sampaio, Francisco, Ferreira, Diogo, Thiele, Holger, Baldus, Stephan, von Bardeleben, Ralph Stephan, Massberg, Steffen, Windecker, Stephan, Lurz, Philipp, Petronio, Anna Sonia, Lindenfeld, JoAnn, Abraham, William T, Metra, Marco, and Hausleiter, Jörg

Subjects
Secondary mitral regurgitation, Guideline-directed medical therapy, 610 Medicine & health, Comorbidities, Heart failure with reduced ejection fraction, Residual mitral regurgitation, Transcatheter edge-to-edge-repair, Cardiology and Cardiovascular Medicine
Abstract

INTRODUCTION Guideline-directed medical therapy (GDMT), based on the combination of beta blockers (BB), renin-angiotensin system inhibitors (RAS-I), and mineralocorticoid-receptor antagonists (MRA), is known to have a major impact on the outcome of the patients with heart failure with reduced ejection fraction (HFrEF). Although GDMT is recommended prior to M-TEER, not all patients tolerate it. We studied the association of GDMT prescription with survival in HFrEF patients undergoing mitral valve transcatheter edge-to-edge repair (M-TEER) for secondary mitral regurgitation (SMR). METHODS AND RESULTS EuroSMR, a European multicenter registry, included SMR patients with left ventricular ejection fraction of less than fifty percent. The outcome was 2-year all-cause mortality. Of 1344 patients, BB, RAS-I, and MRA were prescribed in 1169 (87%), 1012 (75%), and 765 (57%) patients at the time of M-TEER, respectively. Triple GDMT prescription was associated with a lower 2-year all-cause mortality compared to non-triple GDMT (hazard ratio [HR], 0.74; 95% confidence interval [CI], 0.60-0.91). The association persisted in patients with glomerular filtration rate of

Published
2022

211. Corrigendum to: 2021 ESC/EACTS Guidelines for the management of valvular heart disease

Author

Beyersdorf, Friedhelm, Vahanian, Alec, Milojevic, Milan, Praz, Fabien, Baldus, Stephan, Bauersachs, Johann, Capodanno, Davide, Conradi, Lenard, De Bonis, Michele, De Paulis, Ruggero, Delgado, Victoria, Freemantle, Nick, Gilard, Martine, Haugaa, Kristina H, Jeppsson, Anders, Jüni, Peter, Pierard, Luc, Prendergast, Bernard D, Sádaba, J Rafael, Tribouilloy, Christophe, Wojakowski, Wojtek, Beyersdorf, Friedhelm, Vahanian, Alec, Milojevic, Milan, Praz, Fabien, Baldus, Stephan, Bauersachs, Johann, Capodanno, Davide, Conradi, Lenard, De Bonis, Michele, De Paulis, Ruggero, Delgado, Victoria, Freemantle, Nick, Gilard, Martine, Haugaa, Kristina H, Jeppsson, Ander, Jüni, Peter, Pierard, Luc, Prendergast, Bernard D, Sádaba, J Rafael, Tribouilloy, Christophe, and Wojakowski, Wojtek

Subjects
Pulmonary and Respiratory Medicine, Surgery, General Medicine, Cardiology and Cardiovascular Medicine
Published
2022

212. Erratum to: 2021 ESC/EACTS Guidelines for the management of valvular heart disease

Author

Beyersdorf, Friedhelm, Vahanian, Alec, Milojevic, Milan, Praz, Fabien, Baldus, Stephan, Bauersachs, Johann, Capodanno, Davide, Conradi, Lenard, De Bonis, Michele, De Paulis, Ruggero, Delgado, Victoria, Freemantle, Nick, Gilard, Martine, Haugaa, Kristina H, Jeppsson, Anders, Jüni, Peter, Pierard, Luc, Prendergast, Bernard D, Sádaba, J Rafael, Tribouilloy, Christophe, Wojakowski, Wojtek, Beyersdorf, Friedhelm, Vahanian, Alec, Milojevic, Milan, Praz, Fabien, Baldus, Stephan, Bauersachs, Johann, Capodanno, Davide, Conradi, Lenard, De Bonis, Michele, De Paulis, Ruggero, Delgado, Victoria, Freemantle, Nick, Gilard, Martine, Haugaa, Kristina H, Jeppsson, Ander, Jüni, Peter, Pierard, Luc, Prendergast, Bernard D, Sádaba, J Rafael, Tribouilloy, Christophe, and Wojakowski, Wojtek

Subjects
Pulmonary and Respiratory Medicine, Surgery, General Medicine, Cardiology and Cardiovascular Medicine
Published
2022

213. Characteristics and outcomes of patients screened for transcatheter mitral valve implantation: 1-year results from the CHOICE-MI registry

Author

Ben Ali, Walid, Ludwig, Sebastian, Duncan, Alison, Weimann, Jessica, Nickenig, Georg, Tanaka, Tetsu, Coisne, Augustin, Vincentelli, Andre, Makkar, Raj, Webb, John G., Akodad, Mariama, Muller, David W.M., Praz, Fabien, Wild, Mirjam G., Hausleiter, Jörg, Goel, Sachin S., von Ballmoos, Moritz Wyler, Denti, Paolo, Chehab, Omar, Redwood, Simon, Dahle, Gry, Baldus, Stephan, Adam, Matti, Ruge, Hendrik, Lange, Rüdiger, Kaneko, Tsuyoshi, Leroux, Lionel, Dumonteil, Nicolas, Tchetche, Didier, Treede, Hendrik, Flagiello, Michele, Obadia, Jean Francois, Walther, Thomas, Taramasso, Maurizio, Søndergaard, Lars, Bleiziffer, Sabine, Rudolph, Tanja K., Fam, Neil, Kempfert, Joerg, Granada, Juan F., Tang, Gilbert H.L., von Bardeleben, Ralph Stephan, Conradi, Lenard, Modine, Thomas, Kalbacher, Daniel, Blankenberg, Stefan, Koell, Benedikt, Schofer, Niklas, Westermann, Dirk, Weber, Marcel, CarMeN, laboratoire, Montreal Heart Institute - Institut de Cardiologie de Montréal, Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf [Hamburg] (UKE), German Center for Cardiovascular Research (DZHK), Berlin Institute of Health (BIH), Cardiovascular Research Foundation [New York, NY, USA] (CRF), Royal Brompton Hospital, Heart Center Bonn [Bonn, Germany] (HCB), University Hospital Bonn, CHU Lille, Cedars-Sinai Medical Center, St. Paul’s Hospital - University of British Columbia [Vancouver, BC, Canada] (SPH-UBC), St. Vincent's Hospital, Sydney, Bern University Hospital [Berne] (Inselspital), Ludwig Maximilian University [Munich] (LMU), Houston Methodist Hospital [Houston, TX, USA], IRCCS Ospedale San Raffaele [Milan, Italy], Guy's and St Thomas' Hospital [London], Oslo University Hospital [Oslo], University Hospital of Cologne [Cologne], German Heart Center = Deutsches Herzzentrum München [Munich, Germany] (GHC), Brigham and Women’s Hospital [Boston, MA], Harvard Medical School [Boston] (HMS), CHU Bordeaux [Bordeaux], Clinique Pasteur [Toulouse], University Medical Center [Mainz], Hôpital Louis Pradel [CHU - HCL], Hospices Civils de Lyon (HCL), Frankfurt University Hospital, Heart Center Hirslanden = HerzZentrum Hirslanden [Zürich, Switzerland] (HCL), Hôpital national = Rigshospitalet [Copenhagen, Denmark] (HNC), Heart and Diabetes Center NRW [Bad Oeynhausen, Germany] (HDC), St. Michael's Hospital, Mount Sinai Hospital [New York City, NY, USA] (MSH), University Heart Center [Hamburg], CHOICE-MI Investigators: Daniel Kalbacher, Stefan Blankenberg, Benedikt Koell, Niklas Schofer, Dirk Westermann, Marcel Weber, Johanna Vogelhuber, François Pontana, Eric Van Belle, Sung-Han Yoon, Anthony Chuang, Robert H Boone, Paul Jansz, Ning Song, Sara Hungerford, Stephan Windecker, David Reineke, Michael Reardon, Neal S Kleiman, Alessandra Sala, Eustachio Agricola, Francesco Maisano, Ronak Rajani, Bernard Prendergast, Kjell A Rein, Maria I Koerber, Laurin Ochs, Keti Vitanova, Magdalena Erlebach, Pinak Shah, Morgan Harloff, Guillaume Bonnet, Mathieu Pernot, Melchior Jonveaux, Felix Kreidel, Tobias Ruf, Matteo Pozzi, Razvan Dragulescu, Tomas Holubec, Heike Strohschnitter, Claudia Walther, Alberto Pozzoli, Ivan Wong, Kai Friedrichs, Mark Peterson, Axel Unbehaun, Markus Kofler., Ben Ali, Walid, Ludwig, Sebastian, Duncan, Alison, Weimann, Jessica, Nickenig, Georg, Tanaka, Tetsu, Coisne, Augustin, Vincentelli, Andre, Makkar, Raj, Webb, John G, Akodad, Mariama, Muller, David W M, Praz, Fabien, Wild, Mirjam G, Hausleiter, Jörg, Goel, Sachin S, von Ballmoos, Moritz Wyler, Denti, Paolo, Chehab, Omar, Redwood, Simon, Dahle, Gry, Baldus, Stephan, Adam, Matti, Ruge, Hendrik, Lange, Rüdiger, Kaneko, Tsuyoshi, Leroux, Lionel, Dumonteil, Nicola, Tchetche, Didier, Treede, Hendrik, Flagiello, Michele, Obadia, Jean-Francoi, Walther, Thoma, Taramasso, Maurizio, Søndergaard, Lar, Bleiziffer, Sabine, Rudolph, Tanja K, Fam, Neil, Kempfert, Joerg, Granada, Juan F, Tang, Gilbert H L, von Bardeleben, Ralph Stephan, Conradi, Lenard, Modine, Thoma, and Agricola, Eustachio

Subjects
Heart Failure, Heart Valve Prosthesis Implantation, Cardiac Catheterization, Medical therapy, [SDV]Life Sciences [q-bio], 610 Medizin, Mitral valve surgery, Mitral Valve Insufficiency, 610 Medicine & health, [SDV] Life Sciences [q-bio], Treatment Outcome, 610 Medical sciences, Humans, Mitral Valve, Registries, Cardiology and Cardiovascular Medicine, Transcatheter mitral valve implantation, Transcatheter edge-to-edge repair, Mitral regurgitation
Abstract

AIMS Transcatheter mitral valve implantation (TMVI) represents a novel treatment option for patients with mitral regurgitation (MR) unsuitable for established therapies. The CHOICE-MI registry aimed to investigate outcomes of patients undergoing screening for TMVI. METHODS AND RESULTS From 05/2014 to 03/2021, patients with MR considered suboptimal candidates for transcatheter edge-to-edge repair (TEER) and at high risk for mitral valve surgery underwent TMVI screening at 26 centres. Characteristics and outcomes were investigated for patients undergoing TMVI and for TMVI-ineligible patients referred to bailout-TEER, high-risk surgery or medical therapy (MT). The primary composite endpoint was all-cause mortality or heart failure hospitalisation after 1 year. Among 746 patients included (78.5 years [IQR 72.0-83.0], EuroSCORE II 4.7% [IQR 2.7-9.7]), 229 patients (30.7%) underwent TMVI with ten different dedicated devices. At 1 year, residual MR ≤1+ was present in 95.2% and the primary endpoint occurred in 39.2% of patients treated with TMVI. In TMVI-ineligible patients (N = 517, 69.3%), rates of residual MR ≤1+ were 37.2%, 100.0% and 2.4% after bailout-TEER, high-risk surgery and MT, respectively. The primary endpoint at 1 year occurred in 28.8% of patients referred to bailout-TEER, in 42.9% of patients undergoing high-risk surgery and in 47.9% of patients remaining on MT. CONCLUSION This registry included the largest number of patients treated with TMVI to date. TMVI with ten dedicated devices resulted in predictable MR elimination and sustained functional improvement at 1 year. In TMVI-ineligible patients, bailout-TEER and high-risk surgery represented reasonable alternatives, while MT was associated with poor clinical and functional outcomes. This article is protected by copyright. All rights reserved.

Published
2022

215. Deep sedation vs. general anesthesia for transcatheter tricuspid valve repair

Author

Haurand, Jean Marc, primary, Kavsur, Refik, additional, Ochs, Laurin, additional, Tanaka, Tetsu, additional, Iliadis, Christos, additional, Sugiura, Atsushi, additional, Kelm, Malte, additional, Nickenig, Georg, additional, Baldus, Stephan, additional, Westenfeld, Ralf, additional, Becher, Marc Ulrich, additional, Pfister, Roman, additional, and Horn, Patrick, additional

Published
2022
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216. Two‐year clinical outcomes after successful transcatheter aortic valve implantation with balloon‐expandable versus self‐expanding valves: A subanalysis of the GALILEO trial

Author

Okuno, Taishi, primary, Dangas, George D., additional, Hengstenberg, Christian, additional, Sartori, Samantha, additional, Herrmann, Howard C., additional, de Winter, Robert, additional, Gilard, Martine, additional, Tchétché, Didier, additional, Möllmann, Helge, additional, Makkar, Raj R., additional, Baldus, Stephan, additional, De Backer, Ole, additional, Bendz, Bjørn, additional, Kini, Annapoorna, additional, von Lewinski, Dirk, additional, Mack, Michael, additional, Moreno, Raúl, additional, Schäfer, Ulrich, additional, Wöhrle, Jochen, additional, Seeger, Julia, additional, Snyder, Clayton, additional, Nicolas, Johny, additional, Tijssen, Jan G. P., additional, Welsh, Robert C., additional, Vranckx, Pascal, additional, Valgimigli, Marco, additional, Mehran, Roxana, additional, Kapadia, Samir, additional, Sondergaard, Lars, additional, and Windecker, Stephan, additional

Published
2022
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217. Trikuspidalklappeninsuffizienz

Author

Möllmann, Helge, primary, von Bardeleben, Ralph Stephan, additional, Dreger, Henryk, additional, Hausleiter, Jörg, additional, Kempf, Tibor, additional, Lubos, Edith, additional, Lurz, Philipp, additional, Nef, Holger, additional, Nickenig, Georg, additional, Raake, Philip, additional, Opitz, Christian, additional, Rudolph, Volker, additional, Schmidt, Hendrik, additional, Schulze, P. Christian, additional, and Baldus, Stephan, additional

Published
2022
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219. Gemeinsamer Kommentar der Deutschen Gesellschaft für Kardiologie (DGK) und der Deutschen Gesellschaft für Thorax‑, Herz- und Gefäßchirurgie (DGTHG) zu den Leitlinien (2021) der ESC/EACTS zum Management von Herzklappenerkrankungen

Author

Baldus, Stephan, primary, Bauersachs, Johann, additional, Beckmann, Andreas, additional, Bleiziffer, Sabine, additional, Böning, Andreas, additional, Conradi, Lenard, additional, Ensminger, Stephan, additional, Falk, Volkmar, additional, Frerker, Christian, additional, Liebetrau, Christoph, additional, Möllmann, Helge, additional, Rudolph, Volker, additional, Schächinger, Volker, additional, Schulze, P. Christian, additional, Thiele, Holger, additional, Walther, Thomas, additional, and Beyersdorf, Friedhelm, additional

Published
2022
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227. Systemic Upregulation of IL-10 (Interleukin-10) Using a Nonimmunogenic Vector Reduces Growth and Rate of Dissecting Abdominal Aortic Aneurysm

Author

Adam, Matti, Kooreman, Nigel Geoffrey, Jagger, Ann, Wagenhäuser, Markus U., Mehrkens, Dennis, Wang, Yongming, Kayama, Yosuke, Toyama, Kensuke, Raaz, Uwe, Schellinger, Isabel N., Maegdefessel, Lars, Spin, Joshua M., Hamming, Jaap F., Quax, Paul H.A., Baldus, Stephan, Wu, Joseph C., and Tsao, Philip S.

Published
2018
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231. Short-Term Outcome and Hemodynamic Performance of Next-Generation Self-Expanding Versus Balloon-Expandable Transcatheter Aortic Valves in Patients With Small Aortic Annulus: A Multicenter Propensity-Matched Comparison

Author

Mauri, Victor, Kim, Won K., Abumayyaleh, Mohammad, Walther, Thomas, Moellmann, Helge, Schaefer, Ulrich, Conradi, Lenard, Hengstenberg, Christian, Hilker, Michael, Wahlers, Thorsten, Baldus, Stephan, Rudolph, Volker, Madershahian, Navid, and Rudolph, Tanja K.

Published
2017
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232. Outcome of Out-of-Hospital Cardiac Arrest Patients Stratified by Pre-Clinical Loading with Aspirin and Heparin: A Retrospective Cohort Analysis.

Author

Macherey-Meyer, Sascha, Heyne, Sebastian, Meertens, Max M., Braumann, Simon, Niessen, Stephan F., Baldus, Stephan, Lee, Samuel, and Adler, Christoph

Subjects
CARDIAC patients, CARDIAC arrest, ACUTE coronary syndrome, HEPARIN, ASPIRIN
Abstract

Background: Out-of-hospital cardiac arrest (OHCA) has a high prevalence of obstructive coronary artery disease and total coronary occlusion. Consequently, these patients are frequently loaded with antiplatelets and anticoagulants before hospital arrival. However, OHCA patients have multiple non-cardiac causes and high susceptibility for bleeding. In brief, there is a gap in the evidence for loading in OHCA patients. Objective: The current analysis stratified the outcome of patients with OHCA according to pre-clinical loading. Material and Methods: In a retrospective analysis of an all-comer OHCA registry, patients were stratified by loading with aspirin (ASA) and unfractionated heparin (UFH). Bleeding rate, survival to hospital discharge and favorable neurological outcomes were measured. Results: Overall, 272 patients were included, of whom 142 were loaded. Acute coronary syndrome was diagnosed in 103 patients. One-third of STEMIs were not loaded. Conversely, 54% with OHCA from non-ischemic causes were pretreated. Loading was associated with increased survival to hospital discharge (56.3 vs. 40.3%, p = 0.008) and a more favorable neurological outcome (80.7 vs. 62.6% p = 0.003). Prevalence of bleeding was comparable (26.8 vs. 31.5%, p = 0.740). Conclusions: Pre-clinical loading did not increase bleeding rates and was associated with favorable survival. Overtreatment of OHCA with non-ischemic origin, but also undertreatment of STEMI-OHCA were documented. Loading without definite diagnosis of sustained ischemia is debatable in the absence of reliable randomized controlled data. [ABSTRACT FROM AUTHOR]

Published
2023
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233. Adjusted Troponin I for Improved Evaluation of Patients with Chest Pain

Author

Boeckel, Jes-Niels, Palapies, Lars, Klotsche, Jens, Zeller, Tanja, von Jeinsen, Beatrice, Perret, Maya F., Kleinhaus, Soeren L., Pieper, Lars, Tzikas, Stergios, Leistner, David, Bickel, Christoph, Stalla, Günter K., Lehnert, Hendrik, Lindahl, Bertil, Wittchen, Hans-Ulrich, Silber, Sigmund, Baldus, Stephan, Maerz, Winfried, Dimmeler, Stefanie, Blankenberg, Stefan, Münzel, Thomas, Zeiher, Andreas M., and Keller, Till

Published
2018
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234. Transapical mitral valve implantation for treatment of symptomatic mitral valve disease: a real-world multicentre experience

Author

Wild, Mirjam G, Kreidel, Felix, Hell, Michaela M, Praz, Fabien, Mach, Markus, Adam, Matti, Reineke, David, Ruge, Hendrik, Ludwig, Sebastian, Conradi, Lenard, Rudolph, Tanja K, Bleiziffer, Sabine, Kellermair, Jörg, Zierer, Andreas, Nickenig, Georg, Weber, Marcel, Petronio, Anna Sonia, Giannini, Cristina, Dahle, Gry, Rein, Kjell A, Coisne, Augustin, Vincentelli, André, Dubois, Christophe, Duncan, Alison, Quarto, Cesare, Unbehaun, Axel, Amat-Santos, Ignacio, Cobiella, Javier, Dumonteil, Nicolas, Estevez-Loureiro, Rodrigo, Fumero, Andrea, Geisler, Tobias, Lurz, Philipp, Mangieri, Antonio, Monivas, Vanessa, Noack, Thilo, Franco, Luis Nombela, Pinon, Miguel A, Stolz, Lukas, Tchétché, Didier, Walter, Thomas, Unsöld, Bernhard, Baldus, Stephan, Andreas, Martin, Hausleiter, Jörg, and von Bardeleben, Ralph S

Subjects
Male, Cardiac Catheterization, Cardiac & Cardiovascular Systems, FEASIBILITY, Heart Valve Diseases, 610 Medicine & health, REGURGITATION, PROSTHESIS, Tendyne, Humans, Mitral regurgitation, Aged, Retrospective Studies, REPAIR, Aged, 80 and over, Heart Failure, Heart Valve Prosthesis Implantation, OUTCOMES, Science & Technology, Mitral Valve Insufficiency, REPLACEMENT, Treatment Outcome, Mitral valve disease, Heart Valve Prosthesis, Cardiovascular System & Cardiology, Mitral Valve, Female, Cardiology and Cardiovascular Medicine, Life Sciences & Biomedicine, Transcatheter mitral valve implantation
Abstract

AIMS: Transcatheter mitral valve implantation (TMVI) is a new treatment option for patients with symptomatic mitral valve (MV) disease. Real-world data have not yet been reported. This study aimed to assess procedural and 30-day outcomes of TMVI in a real-world patient cohort. METHOD AND RESULTS: All consecutive patients undergoing implantation of a transapically delivered self-expanding valve at 26 European centres from January 2020 to April 2021 were included in this retrospective observational registry. Among 108 surgical high-risk patients included (43% female, mean age 75 ± 7 years, mean STS-PROM 7.2 ± 5.3%), 25% was treated for an off-label indication (e.g. previous MV intervention or surgery, mitral stenosis, mitral annular calcification). Patients were highly symptomatic (New York Heart Association [NYHA] functional class III/IV in 86%) and mitral regurgitation (MR) was graded 3+/4+ in 95% (38% primary, 37% secondary, and 25% mixed aetiology). Technical success rate was 96%, and MR reduction to ≤1+ was achieved in all patients with successful implantation. There were two procedural deaths and 30-day all-cause mortality was 12%. At early clinical follow-up, MR reduction was sustained and there were significant reductions of pulmonary pressure (systolic pulmonary artery pressure 52 vs. 42 mmHg, p

Published
2022

238. Elucidation of the genetic causes of bicuspid aortic valve disease

Author

Gehlen, Jan, primary, Stundl, Anja, additional, Debiec, Radoslaw, additional, Fontana, Federica, additional, Krane, Markus, additional, Sharipova, Dinara, additional, Nelson, Christopher P, additional, Al-Kassou, Baravan, additional, Giel, Ann Sophie, additional, Sinning, Jan Malte, additional, Bruenger, Christopher MH, additional, Zelck, Carolin F, additional, Koebbe, Laura L, additional, Braund, Peter S, additional, Webb, Thomas R, additional, Hetherington, Simon, additional, Ensminger, Stephan, additional, Fujita, Buntaro, additional, Mohamed, Salah A, additional, Shrestha, Malakh, additional, Krueger, Heike, additional, Siepe, Matthias, additional, Kari, Fabian Alexander, additional, Nordbeck, Peter, additional, Buravezky, Larissa, additional, Kelm, Malte, additional, Veulemans, Verena, additional, Adam, Matti, additional, Baldus, Stephan, additional, Laugwitz, Karl Ludwig, additional, Haas, Yannick, additional, Karck, Matthias, additional, Mehlhorn, Uwe, additional, Conzelmann, Lars Oliver, additional, Breitenbach, Ingo, additional, Lebherz, Corinna, additional, Urbanski, Paul, additional, Kim, Won Keun, additional, Kandels, Joscha, additional, Ellinghaus, David, additional, Nowak-Goettl, Ulrike, additional, Hoffmann, Per, additional, Wirth, Felix, additional, Doppler, Stefanie, additional, Lahm, Harald, additional, Dreßen, Martina, additional, von Scheidt, Moritz, additional, Knoll, Katharina, additional, Kessler, Thorsten, additional, Hengstenberg, Christian, additional, Schunkert, Heribert, additional, Nickenig, Georg, additional, Nöthen, Markus M, additional, Bolger, Aidan P, additional, Abdelilah-Seyfried, Salim, additional, Samani, Nilesh J, additional, Erdmann, Jeanette, additional, Trenkwalder, Teresa, additional, and Schumacher, Johannes, additional

Published
2022
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239. Left atrial volume index and outcome after transcatheter edge‐to‐edge valve repair for secondary mitral regurgitation

Author

Iliadis, Christos, primary, Kalbacher, Daniel, additional, Lurz, Philipp, additional, Petrescu, Aniela Monica, additional, Orban, Mathias, additional, Puscas, Tania, additional, Lupi, Laura, additional, Stazzoni, Laura, additional, Pires‐Morais, Gustavo, additional, Koell, Benedikt, additional, Besler, Christian, additional, Ruf, Tobias Friedrich, additional, Stolz, Lukas, additional, Tence, Noemie, additional, Adamo, Marianna, additional, Giannini, Cristina, additional, Guerreiro, Cláudio, additional, Hellmich, Martin, additional, Baldus, Stephan, additional, Schofer, Niklas, additional, Thiele, Holger, additional, von Bardeleben, Ralph Stephan, additional, Hausleiter, Jörg, additional, Karam, Nicole, additional, Metra, Marco, additional, Petronio, Anna Sonia, additional, Melica, Bruno, additional, and Pfister, Roman, additional

Published
2022
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240. Guideline-directed medical therapy after transcatheter edge-to-edge mitral valve repair

Author

Tanaka, Tetsu, primary, Kavsur, Refik, additional, Spieker, Maximilian, additional, Iliadis, Christos, additional, Metze, Clemens, additional, Brachtendorf, Birthe M, additional, Horn, Patrick, additional, Zachoval, Christian, additional, Sugiura, Atsushi, additional, Kelm, Malte, additional, Baldus, Stephan, additional, Nickenig, Georg, additional, Westenfeld, Ralf, additional, Pfister, Roman, additional, and Becher, Marc Ulrich, additional

Published
2022
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242. 2021 ESC/EACTS Guidelines for the management of valvular heart disease: Developed by the Task Force for the management of valvular heart disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS)

Author

Vahanian, Alec, primary, Beyersdorf, Friedhelm, additional, Praz, Fabien, additional, Milojevic, Milan, additional, Baldus, Stephan, additional, Bauersachs, Johann, additional, Capodanno, Davide, additional, Conradi, Lenard, additional, De Bonis, Michele, additional, De Paulis, Ruggero, additional, Delgado, Victoria, additional, Freemantle, Nick, additional, Gilard, Martine, additional, Haugaa, Kristina H., additional, Jeppsson, Anders, additional, Jüni, Peter, additional, Pierard, Luc, additional, Prendergast, Bernard D., additional, Sádaba, J. Rafael, additional, Tribouilloy, Christophe, additional, and Wojakowski, Wojtek, additional

Published
2022
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243. Multiparametric MRI identifies subtle adaptations for demarcation of disease transition in murine aortic valve stenosis

Author

Quast, Christine, primary, Kober, Frank, additional, Becker, Katrin, additional, Zweck, Elric, additional, Hoffe, Jasmina, additional, Jacoby, Christoph, additional, Flocke, Vera, additional, Gyamfi-Poku, Isabella, additional, Keyser, Fabian, additional, Piayda, Kerstin, additional, Erkens, Ralf, additional, Niepmann, Sven, additional, Adam, Matti, additional, Baldus, Stephan, additional, Zimmer, Sebastian, additional, Nickenig, Georg, additional, Grandoch, Maria, additional, Bönner, Florian, additional, Kelm, Malte, additional, and Flögel, Ulrich, additional

Published
2022
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245. A staging classification of right heart remodelling for patients undergoing transcatheter edge-to-edge mitral valve repair

Author

Shamekhi, Jasmin, primary, Sugiura, Atsushi, additional, Spieker, Maximilian, additional, Iliadis, Christos, additional, Weber, Marcel, additional, Öztürk, Can, additional, Becher, Marc Ulrich, additional, Tiyerili, Vedat, additional, Zimmer, Sebastian, additional, Horn, Patrick, additional, Westenfeld, Ralf, additional, Pfister, Roman, additional, Mauri, Victor, additional, Sinning, Jan-Malte, additional, Kelm, Malte, additional, Baldus, Stephan, additional, and Nickenig, Georg, additional

Published
2022
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246. D-2 | Cardiac Computed Tomography Angiography Anatomical Characterization of Patients with Primary Aortic Regurgitation

Author

Gogia, Shawn, primary, Vahl, Torsten, additional, Thourani, Vinod H., additional, George, Isaac, additional, Kodali, Susheel K., additional, Hamid, Nadira, additional, Matsumura, Mitsuaki, additional, Maehara, Akiko, additional, Chen, Tiffany, additional, Treede, Hendrik, additional, Baldus, Stephan, additional, Daniels, David, additional, Russo, Mark J., additional, McCabe, James M., additional, Chetcuti, Stanley J., additional, Leon, Martin B., additional, Makkar, Raj, additional, and Khalique, Omar, additional

Published
2022
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247. Surgical Procedure Time and Mortality in Patients with Infective Endocarditis Caused by Staphylococcus aureus or Streptococcus Species

Author

Paul, Gregor, primary, Ochs, Laurin, additional, Hohmann, Christopher, additional, Baldus, Stephan, additional, Michels, Guido, additional, Meyer-Schwickerath, Charlotte, additional, Fätkenheuer, Gerd, additional, Mader, Navid, additional, Wahlers, Thorsten, additional, Weber, Carolyn, additional, and Jung, Norma, additional

Published
2022
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248. Feasibility and Comparison of Resting Full-Cycle Ratio and Computed Tomography Fractional Flow Reserve in Patients with Severe Aortic Valve Stenosis

Author

Wienemann, Hendrik, primary, Langenbach, Marcel C., additional, Mauri, Victor, additional, Banazadeh, Maryam, additional, Klein, Konstantin, additional, Hohmann, Christopher, additional, Lee, Samuel, additional, Breidert, Isabel, additional, Hof, Alexander, additional, Eghbalzadeh, Kaveh, additional, Kuhn, Elmar, additional, Halbach, Marcel, additional, Maintz, David, additional, Baldus, Stephan, additional, Bunck, Alexander, additional, and Adam, Matti, additional

Published
2022
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250. Impact of Right Ventricular Pressure Load After Repair of Tetralogy of Fallot

Author

Latus, Heiner, primary, Stammermann, Jana, additional, Voges, Inga, additional, Waschulzik, Birgit, additional, Gutberlet, Matthias, additional, Diller, Gerhard‐Paul, additional, Schranz, Dietmar, additional, Ewert, Peter, additional, Beerbaum, Philipp, additional, Kühne, Titus, additional, Sarikouch, Samir, additional, Kerst, Gunter, additional, Kanaan, Majed, additional, Lebherz, Corinna, additional, Rüffer, André, additional, Gkalpakiotis, Dimitrios, additional, Schedifka, Andrea, additional, Buheitel, Gernot, additional, Streble, Joachim, additional, Willing, Rainer, additional, Schubert, Stephan, additional, Laser, Kai Thorsten, additional, Sandica, Eugen, additional, Trusen, Burkhard, additional, Berger, Felix, additional, Miera, Oliver, additional, Ovroutski, Stanislav, additional, Schmitt, Katharina, additional, Photiadis, Joachim, additional, Opgen‐Rhein, Bernd, additional, Weiss, Katja, additional, Klaassen, Sabine, additional, Berns, Christoph, additional, Boeckel, Thomas, additional, Haverkämper, Guido, additional, Kästner, Andreas, additional, Koch, Heike, additional, Peters, Björn, additional, Schmidt, Florian, additional, Timme, Jens, additional, Engel, Konstanze, additional, Franzbach, Birgit, additional, Senft, Gabriela, additional, Beyer, Frank, additional, Winter, Klaus, additional, Breuer, Johannes, additional, Schneider, Martin, additional, Bahlmann, Jens, additional, Griese, Eberhard, additional, Lê, Trong Phi, additional, Hebe, Joachim, additional, Nürnberg, Jan‐Hendrik, additional, Magsaam, Annette, additional, Müller, Ronald, additional, Potthoff, Ludger, additional, Voigt, Renate, additional, Krüger, Tim, additional, Gerleve, Hubert, additional, Kleideiter, Ulrich, additional, Schneider‐Kulla, Dirk, additional, Krülls‐Münch, Jürgen, additional, Menke, Thomas, additional, Lehn, Martin, additional, Heilmann, Antje, additional, Tomczak, Helge, additional, Tarusinov, Gleb, additional, Scheid, Michael, additional, Mayatepek, Ertan, additional, Pillekamp, Frank, additional, Lichtenberg, Artur, additional, Terpeluk, Christiane, additional, Kolterer, Bruno, additional, Dittrich, Sven, additional, Gundlach, Ulrike, additional, Cesnjevar, Robert, additional, Müntjes, Carsten, additional, Morf, Geert, additional, Esmaeili, Anoosh, additional, Backhoff, Stephan, additional, Stiller, Brigitte, additional, Beyersdorf, Friedhelm, additional, Kroll, Johannes, additional, Häffner, Nicole, additional, Siaplaouras, Jannos, additional, Masri‐Zada, Antje, additional, Jux, Christian, additional, Böning, Andreas, additional, Akintürk, Hakan, additional, Paul, Thomas, additional, Sigler, Matthias, additional, Tirilomis, Theodor, additional, Schürer, Gabriele, additional, Hartmann, Johannes, additional, Grabitz, Ralph, additional, Liebaug, Uta, additional, Rotzsch, Claudius, additional, Kozlik‐Feldmann, Rainer, additional, Rickers, Carsten, additional, Mir, Thomas, additional, Hübler, Michael, additional, Sachweh, Jörg, additional, Renz, Stefan, additional, Schemm, Andreas, additional, Friedrich, Bernd, additional, Schlobohm, Otmar, additional, Böthig, Dietmar, additional, Wermter, Burkhard, additional, Kelter‐Klöpping, Andrea, additional, Horke, Alexander, additional, Bauersachs, Johann, additional, Westhoff‐Bleck, Mechthild, additional, Gorenflo, Matthias, additional, Karck, Matthias, additional, Loukanov, Tsvetomir, additional, Schrüfer, Hermann, additional, Wilken, Martin, additional, Abdul‐Khaliq, Hashim, additional, Rädle‐Hurst, Tanja, additional, Rentzsch, Axel, additional, Schäfers, Hans‐Joachim, additional, Reichert, Hagen, additional, Vilser, Daniel, additional, Kriebel, Thomas, additional, Boysen, Arnulf, additional, Uebing, Anselm, additional, Attmann, Tim, additional, Cremer, Joachim Thomas, additional, Scheewe, Jens, additional, Buchholz‐Berdau, Regina, additional, Möller, Peter, additional, Horter, Thorsten, additional, Brockmeier, Konrad, additional, Bennink, Gerardus B. W. E, additional, Baldus, Stephan, additional, Gillor, Alex, additional, Niehues, Tim, additional, Lawrenz, Wolfgang, additional, Leidig, Steffen, additional, Dähnert, Ingo, additional, Riede, Frank‐Thomas, additional, Kostelka, Martin, additional, Kändler, Liane, additional, Bethge, Martin, additional, Köster, Stefan, additional, Schröder, Christoph, additional, Karstedt, Jens, additional, Seitz, Uwe, additional, Kampmann, Christoph, additional, Dohle, Daniel‐Sebastian, additional, Stahl, Frank, additional, Abedini, Mojtaba, additional, Müller‐Scholden, Joachim, additional, Hager, Alfred, additional, Huntgeburth, Michael, additional, Kaemmerer, Harald, additional, Nagdyman, Nicole, additional, Schoetzau, Jörg, additional, Tutarel, Oktay, additional, Lange, Rüdiger, additional, Hörer, Jürgen, additional, Haas, Nikolaus A, additional, Hauser, Michael, additional, Roithmaier, Alexander, additional, Kehl, Hans‐Gerd, additional, Lammers, Astrid, additional, Malec, Edward, additional, Baumgartner, Helmut, additional, Diller, Gerhard, additional, Bahle, Roswitha, additional, Hofner, Gerald, additional, Zink, Stefan, additional, Reif, Roland, additional, Singer, Helmut, additional, Parlasca, Christoph, additional, Freund, Matthias W, additional, Schumacher, Michael, additional, Dewald, Oliver, additional, Darrelmann, Christine, additional, Willmann, Olaf, additional, Schmiedl, Norbert, additional, Quick, Peter, additional, Hillebrand, Dirk, additional, Michele Eiselt, Stephan, additional, Nekarda, Torsten, additional, Eberhard, Michael, additional, Baier, Georg, additional, Uhlemann, Frank, additional, Tzanavaros, Ioannis, additional, Beyer, Alexander, additional, Binz, Gudrun, additional, Hess, Steffen, additional, Teufel, Thomas, additional, Handke, Ronald‐Peter, additional, Hofbeck, Michael, additional, Kaulitz, Renate, additional, Sieverding, Ludger, additional, Schlensak, Christian, additional, Apitz, Christian, additional, Kaestner, Michael, additional, Holtvogt, Jürgen, additional, Wippermann, Carl‐Friedrich, additional, Hinz, Sönke, additional, Heusch, Andreas, additional, Wirbelauer, Johannes, additional, and Brosi, Wolfgang, additional

Published
2022
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