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206. Colaboradores

Author

Sarah Abraham, Roshini, Albanesi, Cristina, Alevizos, Ilias, Anguita, Juan, Antiochos, Brendan, Aranow, Cynthia, Atkinson, John P., Austin, Howard A., III, Babu, Subash, Ballow, Mark C., Balow, James E., Belmont, John W., Berek, Claudia, Beukelman, Timothy, Bhavsar, Tapan, Andrew Bird, J., Blutt, Sarah E., Boguniewicz, Mark, Bonamichi-Santos, Rafael, Boisson, Bertrand, Borzova, Elena, Boyaka, Prosper N., Boyce, Joshua, Browne, Sarah K., Burks, Wesley, Bustamante, Jacinta, Calder, Virginia L., Campbell, Matthew, Cardones, Adela Rambi G., Casanova, Jean-Laurent, Castells, Mariana, Cavacini, Lisa A., Chan, Edwin S.L., Chaplin, David D., Winn Chatham, W., Chen, Edward S., Chinen, Javier, Christopher-Stine, Lisa, Ciancanelli, Michael, Cope, Andrew P., Corry, David B., Crea, Filippo, Cron, Randy Q., Cuellar-Rodriguez, Jennifer M., Dalakas, Marinos C., Dann, Sara M., Diamond, Betty, Du Clos, Terry W., Dupuis-Boisson, Stéphanie, Eagar, Todd N., Elmets, Craig A., Erkan, Doruk, Fanning, Laura, Fikrig, Erol, Flego, Davide, Fleisher, Thomas A., Fonacier, Luz, Fontenot, Andrew P., Freeman, Alexandra F., Frew, Anthony J., Fujihashi, Kohtaro, Gadina, Massimo, Gatt, Moshe E., Eric Gershwin, M., Gillespie, Susan L., Goronzy, Jörg J., Goswami, Sangeeta, Grattan, Clive E.H., Greenspan, Neil S., Gupta, Sarthak, Gustafson, Claire E., Hall, Russell P., III, Hamilton, Robert G., Harrington, Laurie E., Harrison, Leonard C., Hasni, Sarfaraz A., Helbling, Arthur, Hester, Joanna, Holland, Steven M., Hourcade, Dennis, Huntington, Nicholas D., Hwangpo, Tracy, Imboden, John B., Issa, Fadi, Izraeli, Shai, Jaffe, Elaine S., Jalkanen, Sirpa, Jones, Stacie, Jouanguy, Emmanuelle, Kabbani, Sarah, Kaufmann, Stefan H.E., Kheradmand, Farrah, Kohn, Donald B., Korngold, Robert, Kovalszki, Anna, Kuhns, Douglas B., Kulkarni, Hrishikesh, Kuo, Caroline Y., Lahouti, Arash, Ola Landgren, C., Laurence, Arian, Lee, Joyce S., Lemière, Catherine, Leung, Donald Y.M., Levinson, Arnold I., Levy, Ofer, Lewis, Dorothy E., Lin, Phoebe, Linkermann, Andreas, Liuzzo, Giovanna, Lockshin, Michael D., Lord, Allison K., Lozier, Jay N., Luong, Amber, Luqmani, Raashid, Mackay, Meggan, Maltzman, Jonathan S., Mannon, Peter J., Manns, Michael P., Martin, James G., Maynard, Craig L., McCash, Samual, McDonald, Douglas R., Melby, Peter C., Miller, Stephen D., Mitchell, Anna L., Mohd-Zaki, Amirah, Mold, Carolyn, Moller, David R., Monos, Dimitrios S., Mueller, Scott N., Mulders-Manders, Catharina M., Mulligan, Mark J., Müller, Ulrich R., Munshi, Pashna N., Murata, Kazunori, Murphy, Philip M., Navasa, Nicolás, Noel, Pierre, Notarangelo, Luigi D., Nussbaum, Robert L., Nutman, Thomas B., Nutt, Stephen L., Oliveira, João B., Ortel, Thomas L., O’Shea, John J., Pai, Sung-Yun, Pandit, Lavannya, Paul, Mary E., Pearce, Simon H.S., Pedicino, Daniela, Peterson, Erik J., Picard, Capucine, Pittaluga, Stefania, Long Priel, Debra, Puck, Jennifer, Puel, Anne, Radbruch, Andreas, Reece, Stephen T., Reveille, John D., Rich, Robert R., Roifman, Chaim M., Rosen, Antony, Rosenbaum, James T., Rosenzweig, Sergio D., Rouse, Barry T., Rowley, Scott D., Sakaguchi., Shimon, Salmi, Marko, Sant, Andrea J., Satola, Sarah W., Saw, Valerie, Schechter, Marcos C., Schroeder, Harry W., Segal, Benjamin M., Selmi, Carlo, Shankar, Sushma, Sharma, Anu, Sharma, Padmanee, Shearer, William T., Siegel, Richard M., Simon, Anna, Smith, Gideon P., Stephens, David S., Stephens, Robin, Straumann, Alex, Teos, Leyla Y., Timares, Laura, Tonnus, Wulf, Torres, Raul M., Uzel, Gülbü, van der Hilst, Jeroen C.H., van der Meer, Jos W.M., Varga, John, Vyas, Jatin M., Waldman, Meryl, Weiser, Peter, Weller, Peter F., Weyand, Cornelia M., Wigley, Fredrick M., Winchester, Robert J., Wing, James B., Wood, Kathryn J., Wu, Xiaobo, Xu, Hui, Yee, Cassian, and Zhang, Shen-Ying

Published
2020
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211. Systems Immunology of Diabetes-Tuberculosis Comorbidity Reveals Signatures of Disease Complications

Author

Prada-Medina, Cesar A., primary, Fukutani, Kiyoshi F., additional, Pavan Kumar, Nathella, additional, Gil-Santana, Leonardo, additional, Babu, Subash, additional, Lichtenstein, Flávio, additional, West, Kim, additional, Sivakumar, Shanmugam, additional, Menon, Pradeep A., additional, Viswanathan, Vijay, additional, Andrade, Bruno B., additional, Nakaya, Helder I., additional, and Kornfeld, Hardy, additional

Published
2017
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212. Tuberculous Lymphadenitis Is Associated with Enhanced Baseline and Antigen-Specific Induction of Type 1 and Type 17 Cytokines and Reduced Interleukin-1β (IL-1β) and IL-18 at the Site of Infection

Author

Kathamuthu, Gokul Raj, primary, Moideen, Kadar, additional, Baskaran, Dhanaraj, additional, Banurekha, Vaithilingam V., additional, Nair, Dina, additional, Sekar, Gomathi, additional, Sridhar, Rathinam, additional, Vidyajayanthi, Bharathi, additional, Gajendraraj, Ganeshan, additional, Parandhaman, Dinesh Kumar, additional, Srinivasan, Alena, additional, and Babu, Subash, additional

Published
2017
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217. Unbiased Identification of Blood-based Biomarkers for Pulmonary Tuberculosis by Modeling and Mining Molecular Interaction Networks

Author

Sambarey, Awanti, primary, Devaprasad, Abhinandan, additional, Mohan, Abhilash, additional, Ahmed, Asma, additional, Nayak, Soumya, additional, Swaminathan, Soumya, additional, D'Souza, George, additional, Jesuraj, Anto, additional, Dhar, Chirag, additional, Babu, Subash, additional, Vyakarnam, Annapurna, additional, and Chandra, Nagasuma, additional

Published
2017
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220. Metabolic Consequences of Concomitant Strongyloides stercoralis Infection in Patients With Type 2 Diabetes Mellitus.

Author

Rajamanickam, Anuradha, Munisankar, Saravanan, Bhootra, Yukthi, Dolla, Chandrakumar, Thiruvengadam, Kannan, Nutman, Thomas B, and Babu, Subash

Subjects
BLOOD sugar analysis, TYPE 2 diabetes prevention, TYPE 2 diabetes risk factors, ANTHELMINTICS, AGE distribution, CYTOKINES, GLUCAGON, GLYCOSYLATED hemoglobin, HELMINTHIASIS, INFLAMMATION, INSULIN, KIDNEY function tests, MULTIVARIATE analysis, PROTEOLYTIC enzymes, SEX distribution, SOILS, T cells, BODY mass index, TREATMENT effectiveness, ADIPOKINES, GLYCEMIC control, THERAPEUTICS
Abstract

Background Human and animal studies have demonstrated that helminth infections are associated with a decreased prevalence of type 2 diabetes mellitus (T2DM). However, very little is known about their biochemical and immunological interactions. Methods To assess the relationship between a soil-transmitted helminth, Strongyloides stercoralis (Ss), and T2DM, we examined analytes associated with glycemic control, metabolic processes, and T-cell–driven inflammation at the time of Ss diagnosis and 6 months after definitive anthelmintic treatment. We measured plasma levels of hemoglobin A1c, glucose, insulin, glucagon, adipocytokines, and T-helper (TH) 1-, 2-, and 17- associated cytokines in patients with T2DM with (INF group) or without (UN group) Ss infection. In INF individuals, we again assessed the levels of these analytes 6 months following anthelmintic treatment. Results Compared to UN individuals, INF individuals exhibited significantly diminished levels of insulin and glucagon that increased significantly following therapy. Similarly, INF individuals exhibited significantly diminished levels of adiponectin and adipsin that reversed following therapy. INF individuals also exhibited significantly decreased levels of the TH1- and TH17- associated cytokines in comparison to UN individuals; again, anthelmintic therapy augmented these levels. As expected, INF individuals had elevated levels of TH2-associated and regulatory cytokines that normalized following definitive therapy. Multivariate analysis revealed that these changes were independent of age, sex, body mass index, and liver and renal function. Conclusions Strongyloides stercoralis infection is associated with a significant modulation of glycemic, hormonal, and cytokine parameters in T2DM and its reversal following anthelmintic therapy. Hence, Ss infection has a protective effect on diabetes-related parameters. [ABSTRACT FROM AUTHOR]

Published
2019
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221. Elevated circulating levels of monocyte activation markers among tuberculosis patients with diabetes co‐morbidity.

Author

Kumar, Nathella P., Moideen, Kadar, Bhootra, Yukthi, Nancy, Arul, Viswanathan, Vijay, Shruthi, Basavaradhya S., Sivakumar, Shanmugam, Natarajan, Mohan, Kornfeld, Hardy, and Babu, Subash

Subjects
TUBERCULOSIS patients, PROTEINS, TISSUES
Abstract

Summary: Alteration in the frequency of monocyte subsets is a hallmark of tuberculosis–diabetes co‐morbidity (TB‐DM). To study this association, we examined the plasma levels of sCD14, sCD163, C‐reactive protein (CRP) and soluble tissue factor (sTF) in individuals with TB‐DM, TB or diabetes mellitus (DM), and in healthy controls (HC). Circulating levels of sCD14, sCD163 and sTF were significantly increased in TB‐DM and DM compared with TB and HC; however, CRP was significantly increased in TB‐DM and TB compared with DM and HC. During longitudinal follow up, sCD14, CRP and sTF levels remained significantly increased in TB‐DM compared with TB from baseline (pre‐treatment), during treatment (2nd month) and at the completion (6th month) of anti‐TB treatment (ATT), whereas sCD163 was significantly higher in TB‐DM compared with TB only at baseline. Moreover, the levels of sCD14 and sCD163 were significantly higher in TB‐DM individuals with bilateral and cavitary disease and exhibited a significant positive relationship with bacterial burden. Levels of sCD14, sCD163 and CRP exhibited a positive relationship with HbA1c levels. Within the TB‐DM group, those with known diabetes before incident TB (KDM) exhibited significantly higher levels of sCD14 and sCD163 compared with individuals with newly diagnosed DM with TB (NDM). Finally, KDM individuals on metformin treatment exhibited significantly lower levels of sCD14, sCD163 and CRP compared with those on non‐metformin‐containing regimens. Our data demonstrate that systemic monocyte activation marker levels reflect baseline disease severity and extent in TB‐DM, differentiate KDM from NDM and are modulated by ATT and metformin therapy. Our data demonstrate that systemic monocyte activation marker levels reflect baseline disease severity and extent in TB with diabetes, differentiate known DM from new DM and are modulated by anti‐TB treatment and metformin therapy. [ABSTRACT FROM AUTHOR]

Published
2019
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222. Safety profile of BCG revaccination for COVID prevention among elderly individuals in India

Author

Devaleenal Daniel, Bella, Venkatesan, Mythily, Padmapriyadarsini, Chandrasekaran, Thakor, Mahendra, Pereira, Pratibha, Srinivasan, R., Ketharam, Asha, Sabde, Yogesh, Pavan Kumar, N., Gowda, Vidya, Hadaye, Rujuta, Shrinivasa, B.M., Bettappa, Prashantha, Mohan, Anant, KushiyaSri, Sreelakshmi, Manjunath, P.H., Bhavani, P.K., Sangwan, Ramesh K., Tejaswini, C.J., Balachander, Rakesh, Madhanraj, K., Kumar, Praveen, Nataraj, Gita, Kumari, Amrutha, Guleria, Randeep, Prabakaran, Sreelal T., Huda, Ramesh K., Balaji, Chiman, Vikas, Gundappa, Vivek, Shah, Daksha, Srivastava, Garima, Menon, Vishnu B., Sagar, Amit, Truchna, Tanwi, Sathish, Syama, Manda, Balwant, Kumar, Manoj, Bansali, Suman, Sarma, Devojit K., Singh, Surya, Panwalkar, Nikita, Toteja, G.S., Sarkar, Kamalesh, Tiwari, R.R., Murekhar, Manoj, Gupta, Nivedita, and Babu, Subash

Abstract

BCG vaccination is known to be safe in infants and a part of immunization schedule in high tuberculosis (TB) burden countries. In the conquest to bring down the severity of the COVID 19 pandemic, many drugs were repurposed in research mode including BCG vaccination/revaccination in various populations. We did a study among the elderly population (>60 years of age) to assess the role of BCG revaccination in preventing the severity of COVID 19 disease. Live attenuated BCG vaccine was given to the willing participants and were followed up for 6 months to estimate COVID19 incidence, understand severity and immunogenicity profile. A total of 48 serious adverse events (SAE) were reported among 1566 elders, none of them had more than one SAE. None of the SAEs were related to the BCG revaccination. Among the 372 adverse events reported, 96% were local reactions at the vaccine site and resolved on its own. BCG revaccination appeared to be safe and could be explored further if repurposing studies were planned for other diseases.

Published
2024
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223. NK-CD11c+ Cell Crosstalk in Diabetes Enhances IL-6-Mediated Inflammation during Mycobacterium tuberculosis Infection

Author

Cheekatla, Satyanarayana Swamy, primary, Tripathi, Deepak, additional, Venkatasubramanian, Sambasivan, additional, Nathella, Pavan Kumar, additional, Paidipally, Padmaja, additional, Ishibashi, Munenori, additional, Welch, Elwyn, additional, Tvinnereim, Amy R., additional, Ikebe, Mitsuo, additional, Valluri, Vijaya Lakshmi, additional, Babu, Subash, additional, Kornfeld, Hardy, additional, and Vankayalapati, Ramakrishna, additional

Published
2016
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235. Helminth-induced arginase-1 exacerbates lung inflammation and disease severity in tuberculosis

Author

Monin, Leticia, primary, Griffiths, Kristin L., additional, Lam, Wing Y., additional, Gopal, Radha, additional, Kang, Dongwan D., additional, Ahmed, Mushtaq, additional, Rajamanickam, Anuradha, additional, Cruz-Lagunas, Alfredo, additional, Zúñiga, Joaquín, additional, Babu, Subash, additional, Kolls, Jay K., additional, Mitreva, Makedonka, additional, Rosa, Bruce A., additional, Ramos-Payan, Rosalio, additional, Morrison, Thomas E., additional, Murray, Peter J., additional, Rangel-Moreno, Javier, additional, Pearce, Edward J., additional, and Khader, Shabaana A., additional

Published
2015
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236. Modulation of iron status biomarkers in tuberculosis-diabetes co-morbidity.

Author

Kumar, Nathella Pavan, Banurekha, Vaithilingam V., Nair, Dina, Dolla, Chandrakumar, Kumaran, Paul, and Babu, Subash

Abstract

Tuberculosis (TB) and diabetes mellitus (DM) remain vital disease burdens in developing countries and the dual burden of DM and TB clearly signifies a growing global public health concern. While modulation of iron status biomarkers in TB is well described, very little is known about the association of these markers with TB-DM. To examine the association of circulating iron status biomarkers in TB disease, we examined the systemic levels of ferritin, hepcidin, soluble transferrin receptor (sTfR), transferrin, apotransferrin and hemopexin in pulmonary TB (PTB) individuals with DM (PTB-DM), without DM (PTB) and those with diabetes only (DM). Circulating levels of ferritin and hepcidin were significantly enhanced in PTB-DM and PTB compared to the DM group. On the other hand, the circulating levels of transferrin and apotransferrin were significantly diminished in PTB–DM and PTB compared to the DM group. The levels of ferritin and hepcidin exhibited a significant positive relationship with HbA1c, whereas apotransferrin exhibited negative relationship with HbA1c in PTB-DM and PTB. ROC analysis revealed that ferritin, hepcidin and transferrin are markers that can distinguish PTB-DM from DM individuals. Our results suggest that some of these circulating iron status markers could prove useful as biomarkers to monitor disease severity. [ABSTRACT FROM AUTHOR]

Published
2018
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237. Comparison and functional characterisation of peripheral blood mononuclear cells isolated from filarial lymphoedema and endemic normals of a South Indian population.

Author

Nathan, Abel Arul, Dixit, Madhulika, Babu, Subash, and Balakrishnan, Anand Setty

Subjects
FILARIASIS, LYMPHATICS, DISEASES of the anatomical extremities, PARASITES, ENDOTHELIUM, RNA metabolism, MONONUCLEAR leukocytes, ANTIGENS, CELL receptors, CELL motility, COMPARATIVE studies, CYTOKINES, ELEPHANTIASIS, FIBRONECTINS, LYMPHEDEMA, RESEARCH methodology, MEDICAL cooperation, PUBLIC health, REFERENCE values, RESEARCH, EVALUATION research, MEMBRANE glycoproteins, BLOOD, PHYSIOLOGY
Abstract

Copyright of Tropical Medicine & International Health is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2017
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238. Effect of prediabetes on tuberculosis treatment outcomes: A study from South India.

Author

Viswanathan, Vijay, Devarajan, Arutselvi, Kumpatla, Satyavani, Dhanasekaran, Mythili, Babu, Subash, and Kornfeld, Hardy

Abstract

The aim was to assess the effect of prediabetes on tuberculosis(TB) treatment outcomes. This is a prospective observational cohort study of 569 eligible new smear positive cases screened for DM between 2014 and 2018 in TB units in North Chennai, South India. Based on study criteria, a total of 187 subjects were included and categorised into two groups: TB with normoglycaemia (groupI) (HbA1c<5.7%) and TB with prediabetes (group II) (HbA1c = 5.7–6.4%) and followed them at 3rd and 6th month and treatment outcomes were assessed at the end of the TB treatment. Total cure rate was 72.7% with no significant difference between the groups. Higher proportion of deaths occurred in group II (6.3%) compared to group I (1.3%) (p = 0.09). At the end of intensive phase of directly observed therapy (DOTS) treatment, about 23.8% were observed to have positive sputum smear in group II compared to 8.6% in group I(p = 0.019). The estimated relative risk to remain as sputum smear positive among people with prediabetes at the end of intensive phase was 3.0(95% CI: 1.2–7.6). There was a significant association found with HbA1c at enrollment and unfavourable TB treatment outcomes (β = 1.38, [odds ratio (95% CI) 3.98(1.65–9.64); p = 0.007]. Death rate was high and there was a delay in sputum conversion among TB patients with prediabetes at the end of the intensive phase of TB treatment. HbA1c at the time of diagnosis of prediabetes was significantly associated with unfavourable TB treatment outcomes. • Studies on effect of prediabetes on TB treatment outcomes are sparse. • Death rate was high among TB patients with prediabetes. • There was a delayed sputum conversion in TB patients with prediabetes at the end of the intensive phase of TB treatment. [ABSTRACT FROM AUTHOR]

Published
2023
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241. Heme Oxygenase-1 Regulation of Matrix Metalloproteinase-1 Expression Underlies Distinct Disease Profiles in Tuberculosis

Author

Andrade, Bruno B., primary, Pavan Kumar, Nathella, additional, Amaral, Eduardo P., additional, Riteau, Nicolas, additional, Mayer-Barber, Katrin D., additional, Tosh, Kevin W., additional, Maier, Nolan, additional, Conceição, Elisabete L., additional, Kubler, Andre, additional, Sridhar, Rathinam, additional, Banurekha, Vaithilingam V., additional, Jawahar, Mohideen S., additional, Barbosa, Theolis, additional, Manganiello, Vincent C., additional, Moss, Joel, additional, Fontana, Joseph R., additional, Marciano, Beatriz E., additional, Sampaio, Elizabeth P., additional, Olivier, Kenneth N., additional, Holland, Steven M., additional, Jackson, Sharon H., additional, Moayeri, Mahtab, additional, Leppla, Stephen, additional, Sereti, Irini, additional, Barber, Daniel L., additional, Nutman, Thomas B., additional, Babu, Subash, additional, and Sher, Alan, additional

Published
2015
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246. Treatment of W. bancrofti (Wb) in HIV/Wb Coinfections in South India

Author

Talaat, Kawsar R., primary, Babu, Subash, additional, Menon, Pradeep, additional, Kumarasamy, N., additional, Sharma, Jabin, additional, Arumugam, Jeeva, additional, Dhakshinamurthy, Kalaivani, additional, Srinivasan, Ramalingam, additional, Poongulali, S., additional, Gu, Wenjuan, additional, Fay, Michael P., additional, Swaminathan, Soumya, additional, and Nutman, Thomas B., additional

Published
2015
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