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1D organic metal halide hybrids (OMHHs) exhibit strongly anisotropic optical properties, highly efficient light emission, and large Stokes shift, holding promise for novel photodetection and lighting applications. However, the fundamental mechanisms governing their unique optical properties and in particular the impacts of surface effects are not understood. Herein, 1D C4N2H14PbBr4 by polarization-dependent time-averaged and time-resolved photoluminescence (TRPL) spectroscopy, as a function of photoexcitation energy, is investigated. Surprisingly, it is found that the emission under photoexcitation polarized parallel to the 1D metal halide chains can be either stronger or weaker than that under perpendicular polarization, depending on the excitation energy. The excitation-energy-dependent anisotropic emission is attributed to fast surface recombination, supported by first-principles calculations of optical absorption in this material. The fast surface recombination is directly confirmed by TRPL measurements, when the excitation is polarized parallel to the chains. The comprehensive studies provide a more complete picture for a deeper understanding of the optical anisotropy in 1D OMHHs.

In this study, we aimed to review scientific studies and research to present a view of artificial intelligence in education to achieve sustainable development in accordance with the foundations of the Kingdom's Vision 2030. We conducted a systematic review of previous literature by extrapolating and analyzing 17 previous studies published from 2018 to 2020. We found that the application of artificial intelligence has proven effective in improving and developing education, simplifying basic teaching tasks, assisting managers of educational institutions, and contributing to solving problems and challenges faced by the education sector.

PURPOSEBreast cancer among Emirati patients is characterized by early-onset disease and later stages at presentation. Little is known about the germline genetic variants that may contribute to these observations. The goal of this study is to characterize the rate and implications of germline genetic variants among a cohort of Emirati patients at risk for hereditary breast and ovarian cancer syndrome.MATERIALS AND METHODSA retrospective study was performed to analyze the results of clinical germline genetic testing (March 2020-January 2023) among a cohort of consecutive Emirati patients at risk for hereditary breast and ovarian cancer syndrome: group A: patients with personal history of breast or ovarian cancer (n = 135); group B: unaffected patients with family history of breast or ovarian cancer (n = 37); and group C: patients presenting for cascade testing (n = 20). Management of patients identified to have pathogenic/likely pathogenic (P/LP) variants was analyzed.RESULTSThe rate of P/LP germline variants for each group was: group A: 17.3%, group B: 16.6%, group C: 57.9%. BRCA1 gene was the most commonly identified gene harboring P/LP variants, followed by BRCA2, among this cohort. Four unrelated patients had a recurrent BRCA1 pathogenic variant: c.4065_4068del (p.Asn1355Lysfs*10). Only two patients in this series elected risk-reducing mastectomy and four patients elected risk-reducing bilateral salpingo-oophorectomy.CONCLUSIONA higher rate of P/LP variants is seen among Emirati patients at risk for hereditary breast and ovarian cancer syndrome compared with reports of similar patients from Western populations. Efforts to increase utilization and awareness of germline genetic testing are warranted among Emirati patients.

Necrotic enteritis caused by Clostridium perfringens (C. perfringens) is characterized by poor performance and higher mortality rates in poultry farms. Novel dietary intervention involving bioactive molecules loaded into smart magnetized nano-system with a potent antioxidant function (quercetin-loaded Fe3O4-NPs), was evaluated for their impact on growth performance, intestinal immune and antioxidant defenses, and resistance against Clostridium perfringens in a necrotic enteritis challenge model. Four experimental groups comprising a total of 200 one-day-old Ross 308 broiler chickens were fed different diets: a control basal diet, a diet supplemented with quercetin (300 mg/kg), a diet with Fe3O4-NPs (60 mg/kg), and a diet with quercetin-loaded Fe3O4-NPs (300 mg/kg). These groups were then challenged with C. perfringens during the grower period. Dietary inclusion of quercetin-loaded Fe3O4-NPs prominently reduced C. perfringens colonization and its associated virulence genes expression, which subsequently restored the impaired growth performance and intestinal histopathological changes in challenged broilers. Quercetin-loaded Fe3O4-NPs supplemented group displayed higher Lactobacillus and Bifidobacterium counts, upregulation of intestinal host defense antimicrobial peptides related genes (avian β-defensin 6 and 12) and downregulation of intestinal inflammatory regulated genes (Interleukin-1 beta, C-X-C motif chemokine ligand 8, tumor necrosis factor-α, chemokine C–C motif ligand 20, inducible nitric oxide synthase and cycloox-ygenase-2). Intestinal redox balance was boosted via upregulation of catalase, superoxide dismutase, glutathione peroxidase and heme Oxygenase 1 genes along with simultaneous decrease in hydrogen peroxide, reactive oxygen species and malondialdehyde contents in groups fed quercetin-loaded Fe3O4-NPs. Overall, new nutritional intervention with quercetin-loaded Fe3O4-NPs impacted better immune and antioxidant defenses, attenuated C. perfringens induced necrotic enteritis and contributed to better performance in the challenged birds.

Huanglongbing disease (HLB) is the most severe citrus disease destroying Citrus reticulata L. ‘Kinnow’, the most commonly grown mandarin in Pakistan. It is caused by Candidatus Liberibacter bacterial species and it spreads through the sucking Asian citrus psyllid insect. The current study was designed to investigate the potential impact of plant extract mediated selenium nanoparticles (SeNPs) on antioxidant defense system, fruit quality and protein regulation in the fruits of HLB-infected ‘Kinnow’ mandarin plants. Garlic cloves extract was used as reducing and capping agent for the synthesis of SeNPs. Various concentrations of SeNPs (25, 50, 75, and 100 mg L−1) were exogeneously applied to HLB-positive citrus plants. SeNPs at the concentration of 75 mg L-1 affected positively fruit physio-biochemical parameters, e.g., peel thickness, peel weight, fruit weight, fruit diameter, total soluble solids, juice volume, ascorbic acid content and reduced total acidity. Furthermore, SeNPs also enhanced the amounts of total protein and total sugar as well as elevated antioxidant enzymes, e.g., superoxide dismutase, peroxidases, and catalases. Non-enzymatic antioxidant content, e.g., total phenolic and total flavonoids, was also elevated. Proteomics analysis revealed that exposure to SeNPs at the concentration of 75 mg·L–1 significantly altered in HLB infected mandarin fruting plants the expression of proteins associated with transcription, protection, cell wall biogenesis, cell wall organization, reproduction, stamen formation, embryo development, inflorescence development, as well as translation and response to oxidative stress. Our results revealed that foliar application of SeNPs influences the protein contents positively, therefore ameliorating fruit physio-biochemical quality by boosting antioxidant defense systems of HLB-infected ‘Kinnow’ mandarin plants.

The purpose of this study is to investigate the relationship between PT. Indonesian Classification Bureau Tanjung Perak Surabaya staff' performance and their job experience and discipline. The research methodology employed in this study is associative analysis in quantitative research. Saturated sampling procedures were used in this study, which included 46 employees of the PT. Indonesian Classification Bureau Tanjung Perak Surabaya as the population and sample. The analysis procedure makes use of the Partial Least Squares (PLS) analysis technique. Work experience and work discipline have an impact on employee performance at the main branch of PT. Indonesian Classification Bureau Tanjung Perak Surabaya. So that the company can grow, it is intended that this involvement would have a favorable effect on employee performance in the future.

Phosphorus (P) is considered as an essential element in crop production. Besides, the study of P from the elemental and bio sources impacts on productivity and quality of orange trees could emphasize its utilization importance. This study aimed to evaluate the chemical implication of three treatments of P fertilization (Triple phosphate (TP; 620 and 900 g/tree/year), phosphate rock (PR; 1820 and 2742 g/tree/year) and 1:1 TP:PR on Valencia orange trees (Citrus sinensis L. Osbeckunder). Where, all these treatments were equipped with bio-phosphorus fertilizer (phosphorin) (0 and 5 g/tree/year added twice in the year, Feb. and Jun.). The measurements included leaves nitrogen (N), phosphorus (P) and Potassium (K), number of fruits (NoF), juice weight/volume, total soluble solids (T.S.S.), vitamin C (V.C), and acidity. The results showed that the treatment (50 % TP +50 % PR at 450 + 1371g/tree/year + phosphourin at 5g/tree/year) gave the highest values for all characters i.e. N % in tree leaves 2.61 and 2.69 %, P% in tree leaves 0.16 and 0.17 %, K in tree leaves 1.79 and 1.86 %, number of fruits/tree 412.0 and 420.0, fruit weight 267.0 and 280.0g, fruit weight/tree 110.0 and 117.60 kg, fruit size 260.41 and 272.37 cm3, juice weight 114.1 and 126.15g, fruit juice 44.33 and 44.99 %, juice volume 110.15 and 114.90 cm3, peel thickness 0.58 and 0.60 cm, T.S.S. 12.14 and 12.21 %, T.S.S./Acid ratio 9.07 and 9.41, and V.C 70.15 and 72.44 (mg/100 ml) as well as the lowest total acidity 0.93 and 0.91 %, under both the 1st season and the 2nd one, respectively. In conclusions, as the application of bio-fertilization has improved the quality charcatistics over seasons. Thus, this study opens the way towards the advanced application of bio-P element to understand the biogeochemical cycles, dynamics and function of natural ecosystems elements in agricultural and food security program.

Background: Refugees' parenting behaviour is profoundly influenced by their mental health, which is, in turn, influenced by their situation of displacement. Our research presents the first systematic review on parenting and mental health in protracted refugee situations, where 78% of all refugees reside. Methods: We pre-registered our protocol and screened documents in 22 languages from 10 electronic databases, reports by 16 international humanitarian organisations and region-specific content from the top 100 websites for each of the 72 countries that ‘host’ protracted refugees. Our criteria were empirical papers reporting parenting and parental mental health data on refugees who are in a protracted refugee situation. Studies including only internally displaced or stateless persons were excluded. Results: A total of 18,125 documents were screened and 30 studies were included. We identified a universal pathway linking macro-level stressors in protracted refugee situations, such as movement restrictions and documentation issues, to symptoms of depression and anxiety, which, in turn, led to negative parenting practices. Addtionally, culture-specific pathways were observed in the way parental mental health and parenting were expressed. Situational (e.g., overcrowding) and relational factors (e.g., spousal dynamics) modulated both of these pathways. Biases in the research included the over-representation of specific protracted refugee situations, overreliance on self-reported data, and a heavy focus on mothers while neglecting fathers and other caregivers. Longitudinal research is needed to clarify the directionality and causality between specific macro-level stressors in a given protracted refugee situation and parental mental health and practices. Refugees were rarely consulted or involved in the design of research about their parenting and parental mental health. Conclusion: In recognising the existing links between protracted refugee situations, parental mental health, and parenting, our systematic review calls for a shift in thinking: from focusing solely on the micro aspects that affect ‘refugee parenting’ to understanding and tackling the broader macro-level stressors that drive them. We urge for larger and long-term research efforts that consider diverse protracted refugee situations, greater investment in science communication and diplomacy with governments, and stronger implementation of durable solutions by states to alleviate the roots of refugee parents' distress and negative parenting practices.

Q fever is a zoonosis with a worldwide distribution that is caused by the intracellular bacterium Coxiella burnetii. Although most infections in children are asymptomatic and self-limiting, some experience severe or chronic manifestations. Its manifestations in patients with sickle cell disease are unknown, as there are no reports currently. We report the case of a 4-year-old child with sickle cell disease who was admitted to the intensive care unit with fever, septic shock and fulminant hepatic failure secondary to hepatic sequestration crisis and intrahepatic cholestasis. Coxiella burnetii infection was confirmed by molecular and serologic assays. Empiric therapy with doxycycline had a significant impact on his course, and he made an excellent recovery despite requiring extensive life-supportive measures initially. This is the first report of Q fever in a patient with sickle cell disease, demonstrating its capability to manifest as acute sickle hepatopathy with critical illness.

Introduction Diarrhea is a significant health problem in the Third World. Identification of the pathogen that causes diarrhea is vital for measures to prevent and control this disease. There are also very few reports of diarrhea in Sudan. Our study aimed to determine the Prevalence of specific protozoan pathogens (Entamoeba histolytica, Cryptosporidium parvum., and Giardia spp) in children in Khartoum, Sudan. Methods We conducted a cross-sectional survey among children under five years of age hospitalized with acute diarrhea between April and December 2014. Diarrheal stool samples were collected, and E. histolytica, C. parvum, and Giardia spp were examined using multiplex real-time PCR. Results Four hundred and thirty-seven children with acute diarrhea were included in this study; the higher prevalence of diarrhea was in the age ≤ 2 years old (403, 92.2%), >2–≤4 years (32, 7.3%), and >4–

The application of Bayesian strategies for binary logistic estimation is demonstrated in this article. A modified method of the Bayesian logistic model using the Metropolis-Hasting algorithm is derived and applied to three simulation data sets. We compared the new model with existing classification methods: support vector machine, artificial neural network and regular logistic model. The modified model was used to classify the heart disease dataset. The data came from a database intended for UCI Data Science (https://www.kaggle.com). The clarification accuracy and the time required are checked and compared with other standard methods. It has been shown that the presented model has the best accuracy and efficiency compared to the different classification methods. All calculations were performed with the program R version 4.2.2.

Introduction Childbirth self-efficacy has repeatedly been shown to raise satisfaction with childbirth, reduce the need for analgesic, and promote the use of different childbirth alternatives. However, the measures to improve the childbirth self-efficacy had rarely been investigated among Egyptian primiparous women. Aim The aim of this study is to evaluate the effectiveness of childbirth self-efficacy enhancing classes on labor length and outcomes among Egyptian primiparous women. Methods A quasi-experimental research approach was carried out on prospective, consecutive sample of 148 pregnant women at the end of pregnancy. A prenatal education study group (n = 74) and a control group receiving standard antenatal care (n = 74) make up the first and second groups, respectively. Between October 2021 and October 2022, the study was conducted at the antenatal clinic. The following four tools were employed to fulfill the study's objective: A structured interviewing form, a childbirth self-efficacy inventory, a follow-up checklist for monitoring maternal and neonatal outcomes during labor, and three antenatal education sessions to boost childbirth self-efficacy are all examples of tools that can be used. All statistical analyses were performed using SPSS for windows version 20.0 Results Approximately 68.9% of women in the experimental group gave birth vaginally, compared to 29.7% of those in the control group with (p = .001), according to the study's findings. In the experimental group, regular labor took an average of 8 to 12 h, but it took more than 12 h in the control group. Birth weight (>3000g) in the experimental group compared to (2000–3000 g) in the control group, as well as the Apgar score at 1 min and 5 min, were highly statistically significance between two groups with (p = .001). The means±SD of the childbirth self-efficacy result scores were better in the study group than in control groups regarding length of delivery and vaginal delivery (248.2 ± 19.4 versus 144.6 ± 21.6 and 250.1 ± 18.2 versus 137.9 ± 21.5, respectively). Conclusion According to the findings of this study, antenatal education classes have a real chance of assisting primiparous women in increasing their childbirth self-efficacy and improving maternal and neonatal outcomes.

Immunotherapies are a revolutionary approach to treating cancer by utilizing the body’s immune system to target and combat cancer cells. This approach offers promising alternatives to traditional chemotherapies. Its potential to induce long-lasting remissions and specificity for cancer cells, which minimizes side effects, makes it a cutting-edge treatment with tremendous potential. With the increase of the clinical usage of immunotherapy, evidence emerges of the microbiome’s impact on both tumor growth and response to immunotherapy. The proposed involvement of the microbiome can change treatment efficacy by altering drug metabolism and reshaping the immune system response. Understanding the specific interactions between tumor cells, immune cells, and the microbiome is a critical step in the advancement of immunotherapy. To study the complex interaction between cancer immunity and the microbiome, various preclinical in vivo and in vitro models have been developed. We have recently described the use of an ex vivo preclinical model for anti-cancer treatment outcome prediction –tumor tissue equivalents (organoids). Specifically, immune-reactive tumor organoids are proposed as a novel tool for understanding how the microbiome influences cancer immunity and immunotherapy. More importantly, this platform can utilize patient samples to dissect patient-specific elements regulating cancer immune response and microbiome influence. This review presents the rationale for using the immune-reactive tumor organoids model to study the interactions between the microbiome and cancer immunotherapy. It will discuss available components of the model and analyze their interplay, summarize relevant experimental data, and assess their validity. Additionally, it explores the potential of immune-reactive organoids for personalized treatment approaches. Understanding the microbiome’s role in immunotherapy outcomes will lead to transformative cancer treatment via a simple change of diet or other microbiome manipulations. Ongoing research on microbiome-cancer interactions utilizing the described model systems will lead to innovative treatment strategies and improved patient outcomes.

Introduction Nurses play a vital role in ensuring effective patient care delivery and organizational productivity. Hence, it becomes imperative to prioritize their psychological well-being and explore how its impairment may be associated with their productivity loss. Aims The study aims to investigate the relationship between nurses’ psychological well-being and their work productivity loss by examining how nurses self-reported their own psychological well-being and work productivity loss. Methods A descriptive correlational design was conducted at an Egyptian university hospital. A convenience sample of 400 nurses completed two tools: (a) Outcome Questionnaire-45 was used to assess the psychological well-being of nurses and (b) the Work Productivity and Activity Impairment – General Health Questionnaire was used to measure nurses’ work productivity. Results Among the 400 surveyed nurses, 66.7% reported overall poor psychological well-being. Regarding work productivity loss, 22.8% of nurses missed an average of 974.81 work hours due to absenteeism, and 62.0% lost an average of 10,630 work hours due to presenteeism. Additionally, 75.5% experienced impaired daily living activities. Approximately 13.4% of total working hours were missed due to health problems or psychological distress. Regression analysis revealed that poor psychological well-being significantly predicts work productivity loss, accounting for 2.0% of absenteeism, 11.0% of presenteeism, 17.0% of daily activity impairment, and 9.0% of overall productivity loss, with the model being significant ( p

The current trial aimed to investigate the ameliorative effect of pumpkin seeds extract (PSE, Cucurbita maxima)-supplemented diets against ochratoxin A (OTA) toxicity in terms of growth performance, serum biochemical parameters, antioxidative enzymes, immunity parameters and intestine and liver histopathology of Nile tilapia (Oreochromis niloticus). Two hundred randomly distributed healthy fish (initial weight = 16.84 ± 0.061 g) were divided into four diverse groups. Each group of fish was stocked into five aquaria, each containing 10 fish. The first group was served as control and fed a basal contaminated diet (600 μg OTA/kg diet) while the other three groups were fed OTA contaminated diets and supplemented with graded amounts of PSE (0.25, 0.5 or 1 mg/kg). The treatments used were as follows: OTA + PSE (0.25), OTA + PSE (0.5), and OTA + PSE (1). The results showed that fish administered high levels of PSE significantly boosted growth and feed efficiency parameters. Additionally, supplementing OTA-contaminated diets with 1 mg PSE/kg diet reduced the deleterious effects of OTA on liver enzyme activities (aspartate aminotransferase, and alanine amniotransferase). Meanwhile, the protein constituents were significantly improved in all PSE-supplemented groups. In the same context, the antioxidant characteristics (superoxide dismutase, glutathione peroxidase, total antioxidant activity, and malonaldehyde), proinflammatory cytokines (interleukin-1, IL-1), and immune responses (lysozyme and immunoglobulin M and D) were substantially improved by supplemented feed diets with 1 mg PSE/kg diet, however, tumor necrosis factor was suppressed. Particularly, the OTA levels in the muscle were not detected in the fish group fed OTA-contaminated diets and supplemented with 1 mg PSE/kg diet. Considerably, supplementing OTA-contaminated diets with 1 mg PSE/kg diet considerably improved hepatocytes and hepatoportal pancreas structure, with just a few fatty damaged cells present, and revealed healthy intestinal morphologies. Finally, diets supplemented with 1 mg PSE/kg diet could mitigate OTA's adverse impacts on Nile tilapia growth and health.

This study combines experimental and theoretical approaches to investigate ginger root extract (GRE) as an eco-friendly corrosion inhibitor for mild steel in acidic environments at temperatures ranging from 303 to 333 K. Experimental techniques, including weight loss measurements, were used to assess the inhibiting performance and adsorption behavior of GRE, while GC-MS, FT-IR, and UV–visible spectrophotometric methods provided further characterization. Results indicated that the inhibition efficiency of GRE increased with higher concentrations and decreased with temperature, highlighting its potential to effectively prevent corrosion in H2SO4 medium. GC-MS analysis identified four major phenolic compounds—6-gingerol, 6-isoshogaol, zingerone, and vanillyl glycol—and two secondary metabolites, α-Farnesene and β-Bisabolene. Among these, 6-gingerol, the most active and abundant constituent, was selected for computational studies. Optimal corrosion inhibition of 81.3 % was achieved at 303 K with a GRE concentration of 10 g/L for 1 h. Thermodynamic activation parameters suggested a temperature-dependent process, and alignment with the Langmuir isotherm indicated a physical adsorption mechanism. Quantum chemical calculations for 6-gingerol revealed highest occupied molecular orbital energy (EHOMO) and lowest unoccupied molecular orbital energy (ELUMO) values of -6.286 eV and -0.366 eV, respectively, in its protonated state, and -8.338 eV and -0.247 eV, respectively, in its neutral state. Molecular simulations showed a binding affinity of -4.736 kJ/mol between 6-gingerol and the steel surface, supporting the experimental findings and underscoring the potential of GRE as an effective corrosion inhibitor.

Nonsteriodial anti-inflammatory drugs (NSAIDs) are commonly used by women to control pain associated with menstruation period. The main objective of this study is to determine whether use of NSAIDs has impact on the levels of certain hormones in females or not. A cross-sectional study was conducted between participant women who were taken one of the following NSAIDs including diclofenac, ibuprofein and mefenamic acid, for at least one year and more during menstruation and control women (did not take any medication). Levels of follicle stimulating hormone (FSH), Luteinizing hormone (LH), testosterone, prolactin and thyroid stimulating hormone (TSH) were measured by i-CHROMA method. The results showed that the level of LH significantly increased in groups of women who were taken NSAIDs during menstruation period, as well as diclofenac and mefenamic acid have a significant effect on the level of prolactin However, no clear changes were observed in the levels of FSH and testosterone at any type of NSAIDs that were used by the participant women in this study, the results were variable. No clear associations were observed between types of analgesic use and FSH, testosterone, prolactin and TSH. Further studies are required to confirm definite effect of NSAIDs on these hormones.

Routinely collected health data (RCD) including electronic health records, disease registries, health administrative data and wearables data are not specifically collected for research purposes. Analysis of these data poses unique methodological challenges that must be addressed when conducting research, particularly as availability and use increase. This scoping review aimed to identify methodological challenges in research using RCD from existing literature (registered protocol: https://doi.org/10.17605/OSF.IO/EBM4D). We searched 6 electronic databases, including medical, health economics, nursing and psychology research databases, between Jan 2015 and Jan 2023, combining multiple “RCD” and “research” search terms (e.g., epidemiologic, informatics, pharmaceutical research). After screening abstracts and full-texts, we doubly extracted methodological themes, categorizing them into different study stages. We screened more than 23,000 records and included 430 papers. Bias and confounding were the most common methodological issues identified, discussed in relation to both study design and data analysis. Data quality, including data accuracy, validation, completeness, timeliness and cleaning, also posed substantial challenges, particularly during data processing stage. Record linkage and conducting analyses using distributed health networks also pose unique methodological challenges. Heterogeneity, incorporating social determinants of health and statistical models that address methodological challenges are also described in the literature. External validity and reporting are important considerations for RCD research. Our review identified several methodological challenges facing researchers using RCD. These issues should be addressed to ensure methodologically sound research. These findings will inform the development of a standardized protocol template and accompanying educational platform aimed at enhancing methodological quality and transparency when conducting research using RCD.

Background: The onset of obesity-associated renal injury is insidious and asymptomatic. Therefore, finding an early marker will be extremely useful in its detection. Kidney injury molecule-1 (KIM-1) can be evaluated as an early marker for renal injury in obese children. Methods: This case control study involved two groups: a case group of 45 Egyptian overweight/obese children and a control group of 45 non-obese peers. Anthropometry and blood pressure were measured in both groups. Additionally, KIM-1 and serum creatinine levels were assessed. Results: Compared to the control group, the case group showed a significantly higher systolic (P-value 0.000) and diastolic (P-value 0.002) blood pressure. A significantly higher serum creatinine (P=0.007) and KIM-1 (P=0.001) were also found. Conclusion: It is inferred that obesity impacts renal hemodynamics early in childhood. Thus, identifying a screening marker like KIM-1 is useful for the early diagnosis of renal injury.