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1,193 results on '"Azoulay, D."'

212. 493 RESULTS OF LIVER RETRANSPLANTATION IN A MONOCENTRIC COHORT OF HCV INFECTED PATIENTS

Author

Sobesky, R., primary, Roche, B., additional, Antonini, T.M., additional, Delvart, V., additional, Saliba, F., additional, Ichai, P., additional, Adam, R., additional, Azoulay, D., additional, Castaing, D., additional, Sebagh, M., additional, Roque-Afonso, A.-M., additional, Guettier, C., additional, Samuel, D., additional, and Duclos-Vallée, J.-C., additional

Published
2010
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214. Relationship between graft cytochrome P-450 3A content and early morbidity after liver transplantation

Author

Lemoine A, Azoulay D, Jm, Gries, Ashley Dennison, Castaing D, Fredj G, Debuire B, Fp, Guengerich, Beaune P, and Bismuth H

Subjects
Adult, Graft Rejection, Male, Time Factors, Oxidoreductases, N-Demethylating, Middle Aged, Tissue Donors, Liver Transplantation, Cytochrome P-450 Enzyme System, Liver, Cyclosporine, Microsomes, Liver, Cytochrome P-450 CYP3A, Humans, Female, Aryl Hydrocarbon Hydroxylases
Abstract

Cytochrome P-450 3A metabolizes CsA into several metabolites with very limited pharmacological activity and toxicity. In 40 liver donors, the relative concentrations of P-450 3A was assessed by immunoblot analysis using a specific monoclonal antibody exhibited a 10-fold variation (mean = 92 +/- 50 arbitrary units [AU]/mg) in levels. Problems consequent upon CsA usage (nephrotoxicity, neurotoxicity, and hypertension) occurred in 8 of 34 transplant recipients in the immediate postoperative period, and in these 8 patients the problems were always associated with low graft P-4503A levels (mean = 52 +/- 19 A.U./mg, P = 0.0003, cf. patients with no toxicity). Four of these patients had CsA levels that were also high, but 4 had CsA levels in the therapeutic range. Episodes of early graft rejection were related to higher P-450 3A levels (mean = 110 +/- 24 A.U./mg). Cytochrome P-450 3A levels were also found to be inversely related to CsA whole blood levels (assessed with a specific antibody 12 hr after the intravenous infusion of CsA at 1 mg/kg in the recipients (P0.02). Cytochrome P-450 3A can provide information that should allow individualized immunosuppression with CsA maintaining therapeutic levels but avoiding toxicity in susceptible individuals.

Published
1993

215. Recent developments in liver transplantation

Author

Bismuth H, Azoulay D, and Ashley Dennison

Subjects
Adult, Adenosine, Allopurinol, Organ Preservation Solutions, Organ Preservation, Middle Aged, Glutathione, Tissue Donors, Liver Transplantation, Solutions, Raffinose, Humans, Insulin, Child
Abstract

The many developments that have occurred and continue to occur have also meant that the quality of life experienced by recipients of a successful graft is excellent, with more than 85% of patients returning to normal life and work (even having children). While long-term survival still occurs more frequently in favorable groups such as children with metabolic abnormalities or biliary atresia, results are still extremely good for adults, with 3-year survival figures after transplantation for cirrhosis in the order of 75%. These figures also continue to improve, and with the skill and enthusiasm that workers in this field display they seem destined to continue unabated.

Published
1993

219. 846 ATP RELEASE AFTER PARTIAL HEPATECTOMY REGULATES LIVER REGENERATION

Author

Gonzales, E., primary, Julien, B., additional, Serrière-Lanneau, V., additional, Nicou, A., additional, Doignon, I., additional, Lagoudakis, L., additional, Garcin, I., additional, Azoulay, D., additional, Duclos-Vallée, J.-C., additional, Castaing, D., additional, Samuel, D., additional, Hernandez-Garcia, A., additional, Awad, S., additional, Combettes, L., additional, Thevananther, S., additional, and Tordjmann, T., additional

Published
2009
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220. 221 OUTCOME OF CIRRHOTIC PATIENTS ADMITTED TO THE LIVER ICU AND PREDICTIVE FACTORS OF MORTALITY: RESULTS OF A RECENT COHORT OF 308 PATIENTS

Author

Saliba, F., primary, Levesque, E., additional, Ichai, P., additional, Habbouchi, H., additional, Antonini, T.M., additional, Duclos-Vallee, J.-C., additional, Roche, B., additional, Sobesky, R., additional, Azoulay, D., additional, Adam, R., additional, Castaing, D., additional, and Samuel, D., additional

Published
2009
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221. CO.14 Stéatose et transplantation hépatique (TH) : influence du type histologique et du degré d’envahissement sur les résultats à court et à long terme

Author

Adam, R., primary, Karam, V., additional, Jimenez, A., additional, Sebagh, M., additional, Saliba, F., additional, Ichai, P., additional, Vibert, E., additional, Salloum, C., additional, Perdigao Cotta, F., additional, Duclos-Vallée, J.C., additional, Levesque, E., additional, Azoulay, D., additional, Samuel, D., additional, and Castaing, D., additional

Published
2009
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223. CO.10 Etude de survie à 1 an et à 5 ans des patients retransplantés pour cirrhose virale C sur le greffon – Résultats à partir d’une série appariée

Author

Sobesky, R., primary, Carrier, P., additional, Roche, B., additional, Antonini, T.M., additional, Delvart, V., additional, Saliba, F., additional, Ichai, P., additional, Adam, R., additional, Azoulay, D., additional, Castaing, D., additional, Sebagh, M., additional, Roque-Afonso, A.M., additional, Guettier Bouttier, C., additional, Samuel, D., additional, and Duclos-Vallée, J.C., additional

Published
2009
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226. P.128 Quels sont les facteurs prédictifs de mortalité des patients coinfectés VIH/VHC sur liste d’attente de transplantation hépatique (TH) ?

Author

Carmona, D., primary, Delvart, V., additional, Antonini, T.M., additional, Sobesky, R., additional, Roche, B., additional, Teicher, E., additional, Vittecoq, D., additional, Adam, R., additional, Azoulay, D., additional, Castaing, D., additional, Samuel, D., additional, and Duclos-Vallée, J.C., additional

Published
2009
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230. Is histological diagnosis of primary liver carcinomas with fibrous stroma reproducible among experts?

Author

Malouf, G, primary, Falissard, B, additional, Azoulay, D, additional, Callea, F, additional, Ferrell, L D, additional, Goodman, Z D, additional, Hayashi, Y, additional, Hsu, H-C, additional, Hubscher, S G, additional, Kojiro, M, additional, Ng, I O, additional, Paterson, A C, additional, Reynes, M, additional, Zafrani, E-S, additional, and Emile, J-F, additional

Published
2009
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236. Quels sont les facteurs prédictifs et la valeur pronostique d’une réponse histologique complète en cas de métastases hépatiques d’origine colorectale traitées par chimiothérapie ?

Author

Adam, R., primary, Wicherts, D.A., additional, de Haas, R.J., additional, Aloia, T., additional, Lévi, F., additional, Paule, B., additional, Guettier, C., additional, Kunstlinger, F., additional, Delvart, V., additional, Azoulay, D., additional, and Castaing, D., additional

Published
2008
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240. Résection hépatique après traitement par agents ciblés de métastases hépatiques initialement non résécables n’ayant pas répondu à une chimiothérapie conventionnelle

Author

Adam, R., primary, Aloia, T., additional, Levi, F., additional, Wicherts, D.A., additional, de Haas, R.J., additional, Paule, B., additional, Bralet, M.P., additional, Bouchahda, M., additional, Machover, D., additional, Ducreux, M., additional, Castagne, V., additional, Azoulay, D., additional, and Castaing, D., additional

Published
2008
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242. Efficacité à long terme de la Transplantation Hépatique sur la neuropathie et la survie des patients atteints de Neuropathie Amyloïde Familiale (NAF) liée à une variante Met30 de la Transthyrétine

Author

Adams, D., primary, Lozeron, P., additional, Antonini, T., additional, Kreib, A.M., additional, Azoulay, D., additional, Plante, V., additional, Ducot, B., additional, Castaing, D., additional, Samuel, D., additional, and Said, G., additional

Published
2008
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243. 170 VASOPRESSIN-BASED REFLEX REGULATING PORTAL PRESSURE AND BILE HOMEOSTASIS AFTER PARTIAL HEPATECTOMY IN RATS AND HUMANS

Author

Serriere-Lanneau, V., primary, Alonso, G., additional, Nicou, A., additional, Garcin, I., additional, Gigou, M., additional, Doignon, I., additional, Humbert, L., additional, Rainteau, D., additional, Azoulay, D., additional, Castaing, D., additional, Gillon, M.C., additional, Samuel, D., additional, Duclos-Vallee, J.C., additional, and Tordjmann, T., additional

Published
2008
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250. [36] EVOLUTION OF AETIOLOGY AND OUTCOME IN THE LAST 20 YEARS IN 500 PATIENTS WITH ACUTE LIVER FAILURE. FACTORS PREDICTIVE OF SURVIVAL AND OF NEUROLOGICAL SEQUELLAE

Author

Ichai, P., primary, Faria, L.C., additional, Letierce, A., additional, Saliba, F., additional, Azoulay, D., additional, Antonini, T., additional, Ben Hamida, S., additional, Adam, R., additional, Bismuth, H., additional, Becquemont, L., additional, Castaing, D., additional, and Samuel, D., additional

Published
2007
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