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201. Polymorphisms in TLR4 and TNFA and Risk of Mycobacterium tuberculosis Infection and Development of Active Disease in Contacts of Tuberculosis Cases in Brazil: A Prospective Cohort Study

Author

Cubillos-Angulo, Juan Manuel, primary, Arriaga, María B, additional, Silva, Elisângela C, additional, Müller, Beatriz L A, additional, Ramalho, Daniela M P, additional, Fukutani, Kiyoshi F, additional, Miranda, Pryscila F C, additional, Moreira, Adriana S R, additional, Ruffino-Netto, Antonio, additional, Lapa e Silva, Jose R, additional, Sterling, Timothy R, additional, Kritski, Afrânio L, additional, Oliveira, Martha M, additional, and Andrade, Bruno B, additional

Published
2018
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202. Immunization of Experimental Dogs With Salivary Proteins From Lutzomyia longipalpis, Using DNA and Recombinant Canarypox Virus Induces Immune Responses Consistent With Protection Against Leishmania infantum

Author

Abbehusen, Melissa Moura Costa, primary, Cunha, Jurema, additional, Suarez, Martha Sena, additional, Teixeira, Clarissa, additional, Almeida, Valter dos Anjos, additional, Pereira, Laís da Silva, additional, Bordoni, Marcelo, additional, Gil-Santana, Leonardo, additional, Solcà, Manuela da Silva, additional, Fraga, Deborah Bittencourt Moté, additional, Fischer, Laurent, additional, Bozza, Patricia Torres, additional, Veras, Patricia Sampaio Tavares, additional, Valenzuela, Jesus G., additional, Kamhawi, Shaden, additional, Andrade, Bruno B., additional, and Brodskyn, Claudia I., additional

Published
2018
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203. In situ Immune Signatures and Microbial Load at the Nasopharyngeal Interface in Children With Acute Respiratory Infection

Author

Fukutani, Kiyoshi F., primary, Nascimento-Carvalho, Cristiana M., additional, Bouzas, Maiara L., additional, Oliveira, Juliana R., additional, Barral, Aldina, additional, Dierckx, Tim, additional, Khouri, Ricardo, additional, Nakaya, Helder I., additional, Andrade, Bruno B., additional, Van Weyenbergh, Johan, additional, and de Oliveira, Camila I., additional

Published
2018
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204. Leishmania braziliensis Subverts Necroptosis by Modulating RIPK3 Expression

Author

Luz, Nivea F., primary, Khouri, Ricardo, additional, Van Weyenbergh, Johan, additional, Zanette, Dalila L., additional, Fiuza, Paloma P., additional, Noronha, Almerio, additional, Barral, Aldina, additional, Boaventura, Viviane S., additional, Prates, Deboraci B., additional, Chan, Francis Ka-Ming, additional, Andrade, Bruno B., additional, and Borges, Valeria M., additional

Published
2018
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205. Lysosomal Cathepsin Release Is Required for NLRP3-Inflammasome Activation by Mycobacterium tuberculosis in Infected Macrophages

Author

Amaral, Eduardo P., primary, Riteau, Nicolas, additional, Moayeri, Mahtab, additional, Maier, Nolan, additional, Mayer-Barber, Katrin D., additional, Pereira, Rosana M., additional, Lage, Silvia L., additional, Kubler, Andre, additional, Bishai, William R., additional, D’Império-Lima, Maria R., additional, Sher, Alan, additional, and Andrade, Bruno B., additional

Published
2018
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207. Emergence of Polyfunctional Cytotoxic CD4+ T Cells in Mycobacterium avium Immune Reconstitution Inflammatory Syndrome in Human Immunodeficiency Virus-Infected Patients

Author

Hsu, Denise C, primary, Breglio, Kimberly F, additional, Pei, Luxin, additional, Wong, Chun-Shu, additional, Andrade, Bruno B, additional, Sheikh, Virginia, additional, Smelkinson, Margery, additional, Petrovas, Constantinos, additional, Rupert, Adam, additional, Gil-Santana, Leonardo, additional, Zelazny, Adrian, additional, Holland, Steven M, additional, Olivier, Kenneth, additional, Barber, Daniel, additional, and Sereti, Irini, additional

Published
2018
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208. Tissue factor expression by myeloid cells contributes to protective immune response against Mycobacterium tuberculosis infection: Innate Immunity

Author

Venkatasubramanian, Sambasivan, Welch, Elwyn, Paidipally, Padmaja, Schechter, Melissa E., Idell, Steven, Tvinnereim, Amy R., Jeffers, Ann, Tucker, Torry, Raghunath, Anjana, Cheekatla, Satyanarayana, Vankayalapati, Ramakrishna, Mackman, Nizel, Tripathi, Deepak, and Andrade, Bruno B.

Abstract

Tissue Factor (TF) is a transmembrane glycoprotein that plays an essential role in hemostasis by activating coagulation. TF is also expressed by monocytes/macrophages as part of the innate immune response to infections. In the current study, we determined the role of TF expressed by myeloid cells during Mycobacterium tuberculosis (M. tb) infection by using mice lacking the TF gene in myeloid cells (TFΔ) and human monocyte derived macrophages (MDMs). We found that during M. tb infection, a deficiency of TF in myeloid cells was associated with reduced inducible nitric oxide synthase (iNOS) expression, enhanced arginase 1 (Arg1) expression, enhanced IL-10 production and reduced apoptosis in infected macrophages, which augmented M. tb growth. Our results demonstrate that a deficiency of TF in myeloid cells promotes M2 like phenotype in M .tb infected macrophages. A deficiency in TF expression by myeloid cells was also associated with reduced fibrin deposition and increased matrix metalloproteases (MMP)-2 and MMP-9 mediated inflammation in M. tb infected lungs. Our studies demonstrate that TF expressed by myeloid cells has newly recognized abilities to polarize macrophages and to regulate M. tb growth.

Published
2016
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209. Heme Drives Oxidative Stress-Associated Cell Death in Human Neutrophils Infected with Leishmania infantum

Author

Quintela-Carvalho, Graziele, primary, Luz, Nívea F., additional, Celes, Fabiana S., additional, Zanette, Dalila L., additional, Andrade, Daniela, additional, Menezes, Diego, additional, Tavares, Natália M., additional, Brodskyn, Claudia I., additional, Prates, Deboraci B., additional, Gonçalves, Marilda S., additional, de Oliveira, Camila I., additional, Almeida, Roque P., additional, Bozza, Marcelo T., additional, Andrade, Bruno B., additional, and Borges, Valeria M., additional

Published
2017
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210. Associations between endothelial dysfunction and clinical and laboratory parameters in children and adolescents with sickle cell anemia

Author

Teixeira, Rozana Santos, primary, Terse-Ramos, Regina, additional, Ferreira, Tatiane Anunciação, additional, Machado, Vinícius Ramos, additional, Perdiz, Marya Izadora, additional, Lyra, Isa Menezes, additional, Nascimento, Valma Lopes, additional, Boa-Sorte, Ney, additional, Andrade, Bruno B., additional, and Ladeia, Ana Marice, additional

Published
2017
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211. Inflammatory monocytes expressing tissue factor drive SIV and HIV coagulopathy

Author

Schechter, Melissa E., primary, Andrade, Bruno B., additional, He, Tianyu, additional, Richter, George Haret, additional, Tosh, Kevin W., additional, Policicchio, Benjamin B., additional, Singh, Amrit, additional, Raehtz, Kevin D., additional, Sheikh, Virginia, additional, Ma, Dongying, additional, Brocca-Cofano, Egidio, additional, Apetrei, Cristian, additional, Tracy, Russel, additional, Ribeiro, Ruy M., additional, Sher, Alan, additional, Francischetti, Ivo M. B., additional, Pandrea, Ivona, additional, and Sereti, Irini, additional

Published
2017
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212. Anti-parasite therapy drives changes in human visceral leishmaniasis-associated inflammatory balance

Author

Araújo-Santos, Théo, primary, Andrade, Bruno B., additional, Gil-Santana, Leonardo, additional, Luz, Nívea F., additional, dos Santos, Priscila L., additional, de Oliveira, Fabrícia A., additional, Almeida, Meirielly Lima, additional, de Santana Campos, Roseane Nunes, additional, Bozza, Patrícia T., additional, Almeida, Roque P., additional, and Borges, Valeria M., additional

Published
2017
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213. Systems Immunology of Diabetes-Tuberculosis Comorbidity Reveals Signatures of Disease Complications

Author

Prada-Medina, Cesar A., primary, Fukutani, Kiyoshi F., additional, Pavan Kumar, Nathella, additional, Gil-Santana, Leonardo, additional, Babu, Subash, additional, Lichtenstein, Flávio, additional, West, Kim, additional, Sivakumar, Shanmugam, additional, Menon, Pradeep A., additional, Viswanathan, Vijay, additional, Andrade, Bruno B., additional, Nakaya, Helder I., additional, and Kornfeld, Hardy, additional

Published
2017
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214. Mycobacterium tuberculosis Induction of Heme Oxygenase-1 Expression Is Dependent on Oxidative Stress and Reflects Treatment Outcomes

Author

Rockwood, Neesha, primary, Costa, Diego L., additional, Amaral, Eduardo P., additional, Du Bruyn, Elsa, additional, Kubler, Andre, additional, Gil-Santana, Leonardo, additional, Fukutani, Kiyoshi F., additional, Scanga, Charles A., additional, Flynn, JoAnne L., additional, Jackson, Sharon H., additional, Wilkinson, Katalin A., additional, Bishai, William R., additional, Sher, Alan, additional, Wilkinson, Robert J., additional, and Andrade, Bruno B., additional

Published
2017
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215. Inhibition of heme oxygenase-1 activity suppresses Mycobacterium tuberculosis infection in vivo by a mechanism dependent on T lymphocytes and IFN-γ production

Author

Costa, Diego L, primary, Namasivayam, Sivaranjani, additional, Amaral, Eduardo P, additional, Arora, Kriti, additional, Mittereder, Lara R, additional, Maiga, Mamoudou, additional, Boshoff, Helena I, additional, Goulding, Celia W, additional, Andrade, Bruno B, additional, and Sher, Alan, additional

Published
2017
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217. Sustained elevated levels of C-reactive protein and ferritin in pulmonary tuberculosis patients remaining culture positive upon treatment initiation

Author

Miranda, Pryscila, primary, Gil-Santana, Leonardo, additional, Oliveira, Marina G., additional, Mesquita, Eliene D. D., additional, Silva, Elisangela, additional, Rauwerdink, Anneloek, additional, Cobelens, Frank, additional, Oliveira, Martha M., additional, Andrade, Bruno B., additional, and Kritski, Afrânio, additional

Published
2017
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218. Country of residence is associated with distinct inflammatory biomarker signatures in HIV-infected patients

Author

Manion, Maura, primary, Andrade, Bruno B., additional, DerSimonian, Rebecca, additional, Gu, Wenjuan, additional, Rupert, Adam, additional, Musselwhite, Laura W., additional, Sierra-Madero, Juan G., additional, Belaunzaran-Zamudio, Pablo F., additional, Sanne, Ian, additional, Lederman, Michael M., additional, and Sereti, Irini, additional

Published
2017
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221. Transient Hearing Loss in Adults Associated with Zika Virus Infection

Author

Vinhaes, Eriko S, primary, Santos, Luciane A, additional, Dias, Lislane, additional, Andrade, Nilvano A, additional, Bezerra, Victor H, additional, de Carvalho, Anderson T, additional, de Moraes, Laise, additional, Henriques, Daniele F, additional, Azar, Sasha R, additional, Vasilakis, Nikos, additional, Ko, Albert I, additional, Andrade, Bruno B, additional, Siqueira, Isadora C, additional, Khouri, Ricardo, additional, and Boaventura, Viviane S, additional

Published
2016
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222. Polymorphisms in TLR4 and TNFA and Risk of Mycobacterium tuberculosis Infection and Development of Active Disease in Contacts of Tuberculosis Cases in Brazil: A Prospective Cohort Study.

Author

Cubillos-Angulo, Juan Manuel, Arriaga, María B, Silva, Elisângela C, Müller, Beatriz L A, Ramalho, Daniela M P, Fukutani, Kiyoshi F, Miranda, Pryscila F C, Moreira, Adriana S R, Ruffino-Netto, Antonio, Silva, Jose R Lapa e, Sterling, Timothy R, Kritski, Afrânio L, Oliveira, Martha M, and Andrade, Bruno B

Subjects
TUBERCULOSIS risk factors, CONFIDENCE intervals, GENETIC polymorphisms, LONGITUDINAL method, REGRESSION analysis, TUBERCULIN test, TUMOR necrosis factors, GENETIC testing, LOGISTIC regression analysis, DISEASE progression, TOLL-like receptors, DESCRIPTIVE statistics, ODDS ratio
Abstract

Background The role of genetic polymorphisms in latent tuberculosis (TB) infection and progression to active TB is not fully understood. Methods We tested the single-nucleotide polymorphisms (SNPs) rs5743708 (TLR2), rs4986791 (TLR4), rs361525 (TNFA), rs2430561 (IFNG) rs1143627 (IL1B) as risk factors for tuberculin skin test (TST) conversion or development of active TB in contacts of active TB cases. Contacts of microbiologically confirmed pulmonary TB cases were initially screened for longitudinal evaluation up to 24 months, with clinical examination and serial TST, between 1998 and 2004 at a referral center in Brazil. Data and biospecimens were collected from 526 individuals who were contacts of 177 active TB index cases. TST conversion was defined as induration ≥5 mm after a negative TST result (0 mm) at baseline or month 4 visit. Independent associations were tested using logistic regression models. Results Among the 526 contacts, 60 had TST conversion and 44 developed active TB during follow-up. Multivariable regression analysis demonstrated that male sex (odds ratio [OR]: 2.3, 95% confidence interval [CI]: 1.1–4.6), as well as SNPs in TLR4 genes (OR: 62.8, 95% CI: 7.5–525.3) and TNFA (OR: 4.2, 95% CI: 1.9–9.5) were independently associated with TST conversion. Moreover, a positive TST at baseline (OR: 4.7, 95% CI: 2.3–9.7) and SNPs in TLR4 (OR: 6.5, 95% CI: 1.1–36.7) and TNFA (OR: 12.4, 95% CI:5.1–30.1) were independently associated with incident TB. Conclusions SNPs in TLR4 and TNFA predicted both TST conversion and active TB among contacts of TB cases in Brazil. [ABSTRACT FROM AUTHOR]

Published
2019
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223. Gene Expression Profile of High IFN-γ Producers Stimulated with Leishmania braziliensis Identifies Genes Associated with Cutaneous Leishmaniasis

Author

Carneiro, Marcia W., primary, Fukutani, Kiyoshi F., additional, Andrade, Bruno B., additional, Curvelo, Rebecca P., additional, Cristal, Juqueline R., additional, Carvalho, Augusto M., additional, Barral, Aldina, additional, Van Weyenbergh, Johan, additional, Barral-Netto, Manoel, additional, and de Oliveira, Camila I., additional

Published
2016
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225. Role of LTA4H Polymorphism in Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome Occurrence and Clinical Severity in Patients Infected with HIV

Author

Narendran, Gopalan, primary, Kavitha, Dhanasekaran, additional, Karunaianantham, Ramesh, additional, Gil-Santana, Leonardo, additional, Almeida-Junior, Jilson L., additional, Reddy, Sirasanambatti Devarajulu, additional, Kumar, Marimuthu Makesh, additional, Hemalatha, Haribabu, additional, Jayanthi, Nagesh Nalini, additional, Ravichandran, Narayanan, additional, Krishnaraja, Raja, additional, Prabhakar, Angamuthu, additional, Manoharan, Tamizhselvan, additional, Nithyananthan, Lokeswaran, additional, Arjunan, Gunasundari, additional, Natrajan, Mohan, additional, Swaminathan, Soumya, additional, and Andrade, Bruno B., additional

Published
2016
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227. Circulating Biomarkers of Immune Activation, Oxidative Stress and Inflammation Characterize Severe Canine Visceral Leishmaniasis

Author

Solcà, Manuela S., primary, Andrade, Bruno B., additional, Abbehusen, Melissa Moura Costa, additional, Teixeira, Clarissa R., additional, Khouri, Ricardo, additional, Valenzuela, Jesus G., additional, Kamhawi, Shaden, additional, Bozza, Patrícia Torres, additional, Fraga, Deborah Bittencourt Mothé, additional, Borges, Valeria Matos, additional, Veras, Patrícia Sampaio Tavares, additional, and Brodskyn, Claudia Ida, additional

Published
2016
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230. Inflammation and Change in Body Weight With Antiretroviral Therapy Initiation in a Multinational Cohort of HIV-Infected Adults

Author

Mave, Vidya, primary, Erlandson, Kristine M., additional, Gupte, Nikhil, additional, Balagopal, Ashwin, additional, Asmuth, David M., additional, Campbell, Thomas B., additional, Smeaton, Laura, additional, Kumarasamy, Nagalingeswaran, additional, Hakim, James, additional, Santos, Breno, additional, Riviere, Cynthia, additional, Hosseinipour, Mina C., additional, Sugandhavesa, Patcharaphan, additional, Infante, Rosa, additional, Pillay, Sandy, additional, Cardoso, Sandra W., additional, Tripathy, Srikanth, additional, Mwelase, Noluthando, additional, Berendes, Sima, additional, Andrade, Bruno B., additional, Thomas, David L., additional, Bollinger, Robert C., additional, and Gupta, Amita, additional

Published
2016
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231. Vitamin D, d -dimer, Interferon γ, and sCD14 Levels are Independently Associated with Immune Reconstitution Inflammatory Syndrome: A Prospective, International Study

Author

Musselwhite, Laura W., primary, Andrade, Bruno B., additional, Ellenberg, Susan S., additional, Tierney, Ann, additional, Belaunzaran-Zamudio, Pablo F., additional, Rupert, Adam, additional, Lederman, Michael M., additional, Sanne, Ian, additional, Sierra Madero, Juan G., additional, and Sereti, Irini, additional

Published
2016
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233. Mycobacterium tuberculosis dysregulates MMP/TIMP balance to drive rapid cavitation and unrestrained bacterial proliferation.

Author

Kübler, André, Luna, Brian, Larsson, Christer, Ammerman, Nicole C, Andrade, Bruno B, Orandle, Marlene, Bock, Kevin W, Xu, Ziyue, Bagci, Ulas, Molura, Daniel J, Marshall, John, Burns, Jay, Winglee, Kathryn, Ahidjo, Bintou Ahmadou, Cheung, Laurene S, Klunk, Mariah, Jain, Sanjay K, Kumar, Nathella Pavan, Babu, Subash, Sher, Alan, Friedland, Jon S, Elkington, Paul T G, Bishai, William R, Kübler, André, Luna, Brian, Larsson, Christer, Ammerman, Nicole C, Andrade, Bruno B, Orandle, Marlene, Bock, Kevin W, Xu, Ziyue, Bagci, Ulas, Molura, Daniel J, Marshall, John, Burns, Jay, Winglee, Kathryn, Ahidjo, Bintou Ahmadou, Cheung, Laurene S, Klunk, Mariah, Jain, Sanjay K, Kumar, Nathella Pavan, Babu, Subash, Sher, Alan, Friedland, Jon S, Elkington, Paul T G, and Bishai, William R

Abstract

Active tuberculosis (TB) often presents with advanced pulmonary disease, including irreversible lung damage and cavities. Cavitary pathology contributes to antibiotic failure, transmission, morbidity and mortality. Matrix metalloproteinases (MMPs), in particular MMP-1 are implicated in TB pathogenesis. We explored the mechanisms relating MMP/TIMP imbalance to cavity formation in a modified rabbit model of cavitary TB. Our model results in consistent progression of consolidation to human-like cavities (100% by day 28) with resultant bacillary burdens (>10(7) CFU/g) far greater than those found in matched granulomatous tissue (10(5) CFU/g). Using a novel, breath-hold computerized tomography scanning and image analysis protocol. We show that cavities develop rapidly from areas of densely consolidated tissue. Radiological change correlated with a decrease in functional lung tissue as estimated by changes in lung density during controlled pulmonary expansion (R(2) =0.6356, p < 0.0001). We demonstrated that the expression of interstitial collagenase (MMP-1) is specifically greater in cavitary compared to granulomatous lesions (p < 0.01), and that TIMP-3 significantly decreases at the cavity surface. Our findings demonstrate that an MMP-1/TIMP imbalance, is associated with the progression of consolidated regions to cavities containing very high bacterial burdens. Our model provided mechanistic insight, correlating with human disease at the pathological, microbiological and molecular levels,. It also provides a strategy to investigate therapeutics in the context of complex TB pathology. We used these findings to predict a MMP/TIMP balance in active TB; and confirmed this in human plasma, revealing the potential of MMP/TIMP levels as key components of a diagnostic matrix aimed at distinguishing active from latent TB (PPV=92.9%; 95%CI 66.1-99.8%, NPV=85.6%; 95%CI 77.0-91.9%).

Published
2015
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234. Differential Expression of the Eicosanoid Pathway in Patients With Localized or Mucosal Cutaneous Leishmaniasis

Author

França-Costa, Jaqueline, primary, Andrade, Bruno B., additional, Khouri, Ricardo, additional, Van Weyenbergh, Johan, additional, Malta-Santos, Hayna, additional, da Silva Santos, Claire, additional, Brodyskn, Cláudia I., additional, Costa, Jackson M., additional, Barral, Aldina, additional, Bozza, Patrícia T., additional, Boaventura, Viviane, additional, and Borges, Valeria M., additional

Published
2015
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235. Tissue factor expression by myeloid cells contributes to protective immune response againstMycobacterium tuberculosisinfection

Author

Venkatasubramanian, Sambasivan, primary, Tripathi, Deepak, additional, Tucker, Torry, additional, Paidipally, Padmaja, additional, Cheekatla, Satyanarayana, additional, Welch, Elwyn, additional, Raghunath, Anjana, additional, Jeffers, Ann, additional, Tvinnereim, Amy R., additional, Schechter, Melissa E, additional, Andrade, Bruno B, additional, Mackman, Nizel, additional, Idell, Steven, additional, and Vankayalapati, Ramakrishna, additional

Published
2015
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236. Cathepsin K Contributes to Cavitation and Collagen Turnover in Pulmonary Tuberculosis

Author

Kubler, Andre, primary, Larsson, Christer, additional, Luna, Brian, additional, Andrade, Bruno B., additional, Amaral, Eduardo P., additional, Urbanowski, Michael, additional, Orandle, Marlene, additional, Bock, Kevin, additional, Ammerman, Nicole C., additional, Cheung, Laurene S., additional, Winglee, Kathryn, additional, Halushka, Marc, additional, Park, Jin Kyun, additional, Sher, Alan, additional, Friedland, Jon S., additional, Elkington, Paul T., additional, and Bishai, William R., additional

Published
2015
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237. Heme Oxygenase-1 Regulation of Matrix Metalloproteinase-1 Expression Underlies Distinct Disease Profiles in Tuberculosis

Author

Andrade, Bruno B., primary, Pavan Kumar, Nathella, additional, Amaral, Eduardo P., additional, Riteau, Nicolas, additional, Mayer-Barber, Katrin D., additional, Tosh, Kevin W., additional, Maier, Nolan, additional, Conceição, Elisabete L., additional, Kubler, Andre, additional, Sridhar, Rathinam, additional, Banurekha, Vaithilingam V., additional, Jawahar, Mohideen S., additional, Barbosa, Theolis, additional, Manganiello, Vincent C., additional, Moss, Joel, additional, Fontana, Joseph R., additional, Marciano, Beatriz E., additional, Sampaio, Elizabeth P., additional, Olivier, Kenneth N., additional, Holland, Steven M., additional, Jackson, Sharon H., additional, Moayeri, Mahtab, additional, Leppla, Stephen, additional, Sereti, Irini, additional, Barber, Daniel L., additional, Nutman, Thomas B., additional, Babu, Subash, additional, and Sher, Alan, additional

Published
2015
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239. Plasma interleukin-18 levels are a biomarker of innate immune responses that predict and characterize tuberculosis-associated immune reconstitution inflammatory syndrome

Author

Tan, Hong Yien, primary, Yong, Yean Kong, additional, Andrade, Bruno B., additional, Shankar, Esaki M., additional, Ponnampalavanar, Sasheela, additional, Omar, Sharifah F.S., additional, Narendran, Gopalan, additional, Kamarulzaman, Adeeba, additional, Swaminathan, Soumya, additional, Sereti, Irini, additional, Crowe, Suzanne M., additional, and French, Martyn A., additional

Published
2015
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240. Prostaglandin E2/Leukotriene B4 balance induced by Lutzomyia longipalpis saliva favors Leishmania infantum infection

Author

Araújo-Santos, Théo, primary, Prates, Deboraci Brito, additional, França-Costa, Jaqueline, additional, Luz, Nívea F, additional, Andrade, Bruno B, additional, Miranda, José Carlos, additional, Brodskyn, Claudia I, additional, Barral, Aldina, additional, Bozza, Patrícia T, additional, and Borges, Valéria Matos, additional

Published
2014
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241. Nuclear Factor κB Activation Pathways During Mycobacterium tuberculosis Infection.

Author

Amaral, Eduardo P. and Andrade, Bruno B.

Subjects
*NF-kappa B, *MYCOBACTERIUM tuberculosis, *PHAGOCYTES, *IMMUNE response, *MOLECULAR structure
Abstract

The interactions between pathogens and host cells and the way by which the immune response is modulated during this process ultimately dictate the fate of infection. Host phagocytes exposed to Mycobacterium tuberculosis (M. tuberculosis) sense microbial-associated molecular patterns and activate a series of signaling pathways. In this setting, activation of the nuclear factor κB (NF-κB) initiates transcription of several key genes involved in orchestration of antimycobacterial effector functions. This review describes these major pathways that govern the outcome of host phagocytes infected with M. tuberculosis. Furthermore, we highlight evidence of how M. tuberculosis modulates activation of NF-κB pathways to evade the host antimycobacterial defense. [ABSTRACT FROM AUTHOR]

Published
2017
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242. Advances in basic and translational tuberculosis research: Proceedings of the first meeting of RePORT international.

Author

Geadas, Carolina, Stoszek, Sonia K., Sherman, David, Andrade, Bruno B., Srinivasan, Sudha, Hamilton, Carol D., and Ellner, Jerrold

Abstract

RePORT International is a collaborative research network of investigators from multiple countries and institutions with the goal of establishing a bio-repository of specimens and clinical data for the study of active TB and latent TB infection (LTBI). During the first meeting of RePORT International in Boston, Massachusetts, the results of research pertinent to TB control and eradication were presented, including advances in the research of Mycobacterium tuberculosis (MTB) persistence and drug resistance, TB diagnostics, drug and vaccine development. [ABSTRACT FROM AUTHOR]

Published
2017
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244. Mycobacterium tuberculosis dysregulates MMP/TIMP balance to drive rapid cavitation and unrestrained bacterial proliferation

Author

Kübler, André, primary, Luna, Brian, additional, Larsson, Christer, additional, Ammerman, Nicole C, additional, Andrade, Bruno B, additional, Orandle, Marlene, additional, Bock, Kevin W, additional, Xu, Ziyue, additional, Bagci, Ulas, additional, Mollura, Daniel J, additional, Marshall, John, additional, Burns, Jay, additional, Winglee, Kathryn, additional, Ahidjo, Bintou Ahmadou, additional, Cheung, Laurene S, additional, Klunk, Mariah, additional, Jain, Sanjay K, additional, Kumar, Nathella Pavan, additional, Babu, Subash, additional, Sher, Alan, additional, Friedland, Jon S, additional, Elkington, Paul TG, additional, and Bishai, William R, additional

Published
2014
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245. Mycobacterial Antigen Driven Activation of CD14++CD16− Monocytes Is a Predictor of Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome

Author

Andrade, Bruno B., primary, Singh, Amrit, additional, Narendran, Gopalan, additional, Schechter, Melissa E., additional, Nayak, Kaustuv, additional, Subramanian, Sudha, additional, Anbalagan, Selvaraj, additional, Jensen, Stig M. R., additional, Porter, Brian O., additional, Antonelli, Lis R., additional, Wilkinson, Katalin A., additional, Wilkinson, Robert J., additional, Meintjes, Graeme, additional, van der Plas, Helen, additional, Follmann, Dean, additional, Barber, Daniel L., additional, Swaminathan, Soumya, additional, Sher, Alan, additional, and Sereti, Irini, additional

Published
2014
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247. Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk

Author

Mayer-Barber, Katrin D., primary, Andrade, Bruno B., additional, Oland, Sandra D., additional, Amaral, Eduardo P., additional, Barber, Daniel L., additional, Gonzales, Jacqueline, additional, Derrick, Steven C., additional, Shi, Ruiru, additional, Kumar, Nathella Pavan, additional, Wei, Wang, additional, Yuan, Xing, additional, Zhang, Guolong, additional, Cai, Ying, additional, Babu, Subash, additional, Catalfamo, Marta, additional, Salazar, Andres M., additional, Via, Laura E., additional, Barry III, Clifton E., additional, and Sher, Alan, additional

Published
2014
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248. Tempol, an Intracellular Antioxidant, Inhibits Tissue Factor Expression, Attenuates Dendritic Cell Function, and Is Partially Protective in a Murine Model of Cerebral Malaria

Author

Francischetti, Ivo M. B., primary, Gordon, Emile, additional, Bizzarro, Bruna, additional, Gera, Nidhi, additional, Andrade, Bruno B., additional, Oliveira, Fabiano, additional, Ma, Dongying, additional, Assumpção, Teresa C. F., additional, Ribeiro, José M. C., additional, Pena, Mirna, additional, Qi, Chen-Feng, additional, Diouf, Ababacar, additional, Moretz, Samuel E., additional, Long, Carole A., additional, Ackerman, Hans C., additional, Pierce, Susan K., additional, Sá-Nunes, Anderson, additional, and Waisberg, Michael, additional

Published
2014
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250. Paradoxical Tuberculosis Immune Reconstitution Inflammatory Syndrome (TB-IRIS) in HIV Patients with Culture Confirmed Pulmonary Tuberculosis in India and the Potential Role of IL-6 in Prediction

Author

Narendran, Gopalan, primary, Andrade, Bruno B., additional, Porter, Brian O., additional, Chandrasekhar, Chockalingam, additional, Venkatesan, Perumal, additional, Menon, Pradeep A., additional, Subramanian, Sudha, additional, Anbalagan, Selvaraj, additional, Bhavani, Kannabiran P., additional, Sekar, Sathiyavelu, additional, Padmapriyadarshini, Chandrasekaran, additional, Kumar, Satagopan, additional, Ravichandran, Narayanan, additional, Raja, Krishnaraj, additional, Bhanu, Kesavamurthy, additional, Mahilmaran, Ayyamperumal, additional, Sekar, Lakshmanan, additional, Sher, Alan, additional, Sereti, Irini, additional, and Swaminathan, Soumya, additional

Published
2013
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