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BACKGROUND: Mesenchymal stem (stromal) cells (MSCs) have a multipotent character, able to differentiate into several cell types, thus MSC serve as a cell reservoir for regenerative medicine. MSC therapeutic potency more associated to their immunosuppressive and anti-inflammatory properties rather than the multipotency, by its mechanism to secrete soluble factors with paracrine actions.CONTENT: MSC paracrine function was known to mediated partly by extracellular vesicles (EVs), which were released predominantly from the endosomal compartment contained in MSC secretome. EV contain a cargo bring micro RNA (miRNA), messenger RNA (mRNA), and proteins from their cells of origin, propose EV as a novel alternative to whole cell therapies, regarding the benefit of EV in safety and easier storage compared to the parent cells.SUMMARY: The discovery of EVs including exosomes in MSC secretome as key of stem cells beneficial function lead to the future hope of using cell-free regenerative therapies.KEYWORDS: MSC, secretome, conditioned media, extracellular vesicle, exosome

BACKGROUND: Giant transformations are going on currently in health care, and the greatest force behind this phenomenon is data.CONTENT: Big data has arrived into medicine field, lead to potential enhancement in accountability, quality, efficiency, and innovation. Most updated, artificial intelligence (AI) and machine-learning (ML) techniques rapidly developed, bring forth the big data analysis into more useful applications, from resource allocation to complex disease diagnosis. To realize this, a very large set of health-care data is needed for algorithms training and evaluation, including patients’ treatment data, patients respond to treatment, and personal patient information, such as genetic data, family history, health behavior, and vital signs.SUMMARY: Precision Health involving preventive, predictive, personalized and precise. The arrival of AI and ML will enhance and facilitates the improvement of this relationship through better accuracy, productivity, and workflow, thus develop a health system that will go beyond just curing disease, but further into wellness that preventing disease before it strikes, thus the patient–doctor bond is expected to be reformed and not be eroded.KEYWORDS: artificial intelligence, machine learning, deep learning, electronic health records, big data

Background: Stroke has always been a complicated disease which affects not only the patient quality of life but also the patient family. In ischemic stroke patients, one of the most complicated outcomes was the disruption of motor function. Increased motor function is a visible positive outcome of stroke patients.Aim: This study aims to measure the motor evoked potentials values which the results might give us more insights into how this disease affects the motor neuron pathway.Methods: This study was an experimental pre-posttest study involved 75 patients diagnosed with chronic ischemic stroke (onset of more than 30 days). The MEPs value was measured by adjusting the IAHF procedure in 2015.Results: There was no significant difference between motor evoked potential value (amplitude, latency, central motor conduction time) pre and post intraarterial heparin procedure (IAHF) (p>0.05). Occasionally, there was a significant difference in latency value in lacunar, subcortical, and cortical-subcortical area after IAHF (pConclusion: This study shows that the size and localization of the affected area might determine the results of IAHF.

Measurement of dryrubbercontent of latex (DRC) is very important factor in the trade transactions of rubber. Determination of temperature and drying time of latex’s DRC need to be studied in order to avo id the excessive difference between farmers and factories so that it can cause loss effect on sale andpurchase of latex transaction. This study aimed to determine the temperature and time factor of the DRC during the drying process and its interaction. The study used a complete random ized design (RAL) with twofactors, i.e. temperature (80oC, 90oC, 100oC, 110oC, 120oC) and time (2, 4, 6 hours) with 3 replications and as control was 100oC for 2 hours. The results showed that the interaction between temperature and time was apparent (p

Latex is a colloidal suspended of rubber particle in rubber tree (Hevea brasiliensis). Technically, the capacity of rubber productivity can be determined by latex collectionperiod after being tapped. The objective of research was to obtain the differences of latex collection period. The study was conducted in September-November 2017 at the Sungei Putih Research Center in Experimental Estate with PB 260 (7 years tapped) on BO-2 (S/2 d3.ET2.5% Ga1.0 6/y(m)).The experimental designused a Randomized Block Design (RBD) with four treatments of latex collection periodi.e 20, 40, 60, 80 minutes after being tapped with three replicates respectively. The parameters observed was gram/tree/tapping (g/p/s), kg/ha/years, latex flow rate (ml/minutes) and total solid content (%).The results showed that latex collection period was significantly different to g/p/s, kg/ha/years and latex flow rate. Total solid content (TSC) was not significantlydifferent in all treatments. The latex collection period of 20 minutes after being tapped had higher productivity than 40, 60, 80 minutes.

BACKGROUND: The mechanism of aging goes along with age, one of which is characterized by cellular senescent, which occurs mostly in adipose tissue. Adipose tissue is the site of accumulation of large cell senescent, in the regulation of obesity and aging. Proteins p53 is marker for cell senescent, which are also known to induce inflammation. This study was aimed to determine the relationship between circulating protein p53 and high sensitivity C-reactive protein (hsCRP) in central obese men with inflammaging.METHODS: The study design is an observational study with cross-sectional approach. The subjects were 75 central obese men (waist circumference/WC > 90 cm), aged ≥ 45 years old. Subjects were divided into 2 age groups, those are middle age group: 45-59 years old (50.7%) and elderly group: ≥ 60 years old (49.3%). Examination of circulating p53 was done using enzyme-linked immunosorbent assay (ELISA) method, and the hsCRP examination was done by chemiluminescent method.RESULTS: It was found that there was a correlation between circulating p53 and hsCRP in elderly (r=-0.414; p

BACKGROUND: Mitochondrial dysfunction known to be associated with most of human inherited disorders and diseases, including neurodegenerative disorders, cardiomyopathies, metabolic syndrome, muscle weakness, cancer, also obesity.CONTENT: Mitochondria charges for multiple anabolic and catabolic circuitries, as the main provider for adenosine triphosphate (ATP). Mitochondria also responsible for cellwide stress responses and control non-apoptotic cell death routines, such as autophagy and regulated necrosis. In other words, mitochondria play an extended role in regulating cellular functions, both vital and lethal, from physiological metabolism to stress responses and death to maintain adult tissue homeostasis. Furthermore, mitochondria are crucial for both embryonic and postembryonic development. Therefore, any defect or alteration in mitochondria signaling pathways will lead to a large number of diseases in human, including premature aging, neurodegenerative disorders, muscle weakness, cardiovascular disorders, and cancer.SUMMARY: Mitochondria perform a dynamic, integrated interconnected network, to maintain tissue homeostasis, beyond the cell boundaries and regulating cells and tissues communication. Certainly any mitochondrial dysfunction could direct to neurodegenerative diseases and metabolic disorders.KEYWORDS: mitochondria, UPR, mitochondrial quality control, proteostasis, mitohormesis, mitochondrial diseases

BACKGROUND: Altered epigenetics is regarded to play quite a role in many chronic diseases including cancer, diabetes, obesity, dyslipidemia, hypertension and neurodegeneration, hence nutrition suggested to contribute in epigenetics and disease.CONTENT: Histone modifications, as a part of epigenetics mechanisms, depend on metabolites which acts as cofactors or substrates. Fluctuating levels of specific metabolites become the direct and rapid mechanisms to influence gene activity. Therefore, these metabolites may have a role as gatekeepers of chromatin, in chromatin landscape modulation as a response to key nutritional cues. Chemical modifications of histones and DNA have a critical role in epigenetic gene regulation including histone acetylation, and DNA methylation. Some enzymes add or remove such chemical modifications, and suggested to be sensitive to changes in intracellular metabolism, such as mutations in the metabolic enzymes succinate dehydrogenase (SDH), fumarate hydratase (FH) and isocitrate dehydrogenase (IDH) can result in cancer.SUMMARY: As a response to their nutrient environment, organisms tend to rapidly alter their gene expression. Many evidences showed an epigenetic regulation of chromatin is coupled to the changes on metabolites levels due to this kind of response. These metabolites will lead the recruitment of transcriptional regulatory complexes to DNA, thus clearly influencing the dynamic chromatin landscape.KEYWORDS: metabolites, enzymes, epigenetics, chromatin, nutrition

Introduction . The current study aimed to assess profiles of peptide YY and ghrelin, visual analog scales (VAS) for hunger and satiety, and ad libitum intake in obese and non-obese women. Methods . This open-label non-randomized interventional study involved obese (BMI ≥ 25–35 kg/m2) and non-obese (BMI 18.5–23.0 kg/m2) women subjects. Levels of peptide YY and ghrelin were determined by radioimmunoassay and enzyme-linked immunosorbent assay (ELISA), respectively, while the degrees of hunger and satiety were measured using visual analog scale (VAS) questionnaires. The results were compared in fasting condition and in 15, 60, 120, and 180 minutes after breakfast with balance composition formulation. This study also compared the ad libitum intake within 4 hours after breakfast. Results . As compared to the non-obese group, the obese group have significantly lower levels of peptide YY in fasting, and in 15, 60, 120, and 180 minutes post-prandial, and smaller AUC (Area Under the Curve) of fasting peptide YY. Furthermore, the obese group showed significantly higher ad libitum intake. The obese group also have lower levels of ghrelin and lower VAS for hunger and higher in VAS for satiety as compared to the non-obese group. Conclusions . There were significant differences in peptide YY level, 4 hours after breakfast ad libitum intake, ghrelin level, and VAS for hunger and satiety, between obese group and non-obese one.

Permasalahan kesehatan diindonesia sangat kompleks khususnya terkait obat masih banyak ditemui di masyarakat. Permasalahan yang berhubungan dengan obat terjadi karena masyarakat kurang paham tentang penggunaan dan penanganan obat yang baik dan benar. Salah satu cara pengelolaan obat yang baik dan benar adalah dengan menerapkan program DAGUSIBU (DApatkan, GUnakan, SImpan, BUang) obat. Berdasarkan informasi yang diperoleh, masyarakat di Ledok Timoho ini belum pernah mendapatkan informasi tentang DAGUSIBU obat, sehingga perlu dilaksanakan sosialisasi tentang DAGUSIBU obat. Kegiatan ini dimaksudkan untuk dapat membagikan informasi tentang penggunaan dan penanganan obat yang benar kepada warga masyarakat di Kotamadya Yogyakarta khususnya warga Ledok Timoho. Metode sosialisasi yang digunakan dalam kegiatan ini adalah pengenalan masalah, pelaksanaan sosialisasi DAGUSIBU obat dengan cara penyuluhan, diskusi interaktif, dan pambagian buku saku DAGUSIBU obat. Kegiatan sosialisasi tentang DAGUSIBU obat berjalan dengan lancar, dan tingkat kehadiran peserta sebanyak 85,6% dari seluruh undangan. Peserta yang hadir dalam sosialisasi sangat antusias dalam mendengarkan penjelasan dan aktif bertanya terkait penggunaan obat dan penanganannya, hal tersebut dapat menunjang terwujudnya program pemerintah dalam peningkatan pelayanan kesehatan bagi masyarakat sekitar Ledok Timoho. Sosialisasi ini mampu meningkatkan pemahaman peserta tentang pengelolaan obat dengan baik dan benar serta diharapkan dapat menerapkan pengetahuan tentang obat tersebut dalam lingkungan keluarga dan masyarakat. Kata kunci : DAGUSIBU, Obat, Sosialisasi

Background: Retinitis Pigmentosa (RP) is a rare retinal genetic disease without available treatment to date. Previous studies show growth factor and regenerative ability of secretome from cultured allogeneic umbilical chord mesenchymal stem cells (UC-MSC). This studyaimed to report multifocal electroretinography of retinal photoreceptor responsefrom RP patients, before and after injection of secretome from allogeneicUC MSC.Patients and Methods: Four subjects with severely damage retina (visual field defect of 25 %- 50% in initial Humphrey perimetry examination) were recruited and givenperibulbar injection of secretome from allogeneic cultured UC-MSC. Visual acuity, visual field examination, multifocal electroretinogram of retinal photoreceptor examination were observed before and periodically after injection until six months periodResults: Overall, we observed subtle changes in N1 and P1 amplitude and implicit time only in ring 1 at 1, 3 and 6 month post secretome injection. Conclusion: Peribulbar injection of allogeneic UC-MSC secretome had very miminal influence on photoreceptor activity in late-stage RP patients.

This research is titled "Tabot As City Branding Of Bengkulu City". The problem of research is the process of forming tabot as a city branding of Bengkulu City. This research uses cultural studies approach by Stuart Hall. This research is a qualitative research with ethnographic research startegy. The analysis unit in this research is an organization, namely the Tourism and Culture Office of Bengkulu City. Data collection was obtained through in-depth interviews on 13 informants, observations of nonparticipant and documentation. The results of this study showed that tabot as the city branding of Bengkulu city was formed through the process of representation of tabot tradition into a tabot festival conducted by the Bengkulu city government. Bengkulu City Government makes tabot as a characteristic of Bengkulu City through a regulatory reproduction process to form tabot as the identity of Bengkulu City. The Government of Bengkulu wants to present Bengkulu as a religious city, has creativity, and a vibrant city that is depicted from the celebration of tabot festival, as well as as a reference for one of the cultural tourism cities.

Lakitan B, Kartika, Susilawati, Wijaya A. 2021. Acclimating leaf celery plant (Apium graveolens) via bottom wet culture to increase its adaptability to the tropical riparian wetland ecosystem. Biodiversitas 22: 320-328. Bottom-wet culture was set up for acclimating leaf celery plant prior to cultivation at shallow water table conditions. The aim of this research was to evaluate adaptability of leaf celery plants to riparian wetland ecosystem. Leaf celery was selected as potential candidate since natural habitat of its wild relatives is marshlands. Shading at 0%, 20%, and 60% was applied to reduced tropical sunlight intensity. Results of this study indicated that soil moisture was significantly increased in plants exposed to 60% shading, but leaf SPAD value was not significantly affected. Leaf celery is a perennial vegetable that can be frequently harvested. Weekly harvesting was rewarded with optimum yield and good quality leaves, i.e. high SPAD value (45.73 to 51.89). Delaying harvest to 3 weeks increased total yield but 52.12% of the harvested leaves were non-marketable. Mother plant of leaf celery produced suckers, but number of suckers only moderately correlated with yield (R2 = 0.56). Plants exposed to 60% shading produced significantly less suckers (9.00) than those exposed to full sunlight (12.46) and 20% shading (12.88) Use of zero intercept linear regression model, with length of leaf midrib (LLM) x leaf wingspan (LWS) as predictor, resulted in a geometrically based and accurate leaf area estimation model (LA = 0.3431(LLM x LWS); R2 = 0.87) for compound leaves of leaf celery plant. In conclusion, the most crucial factor in optimizing quantity and quality of yield was weekly harvesting focusing on marketable-size leaves.

Objectives We performed a cross-sectional study on anthropometric and laboratory characteristics of inhabitants of Rampasasa (Flores, Indonesia). Adults were categorised according to ancestry into three groups: pygmoid (P/P, offspring of pygmoid parents, n=8), mixed pygmoid (P/N, offspring of pygmoid and non-pygmoid parents, n=12) and non-pygmoid (N/N, n=10). Children (n=28) were P/N. Methods Measurements included height, weight, sitting height, arm span, head circumference, haematological analysis and serum albumin, calcium, vitamin D, insulin-like growth factor-I (IGF-I) and IGF binding protein 3 (IGFBP-3). Pubertal stage and bone age was assessed in children. Anthropometric data were expressed as standard deviation score (SDS) for age. IGF-I, IGFBP-3 and IGF-I/IGFBP-3 ratio were expressed as SDS for age, bone age and pubertal stage. Results Mean height SDS showed a gradient from P/P (−4.0) via P/N (−3.2) to N/N (−2.3) (−3.4, −3.1 and −2.2 adjusted for age-associated shrinking). Sitting height and head circumference showed similar gradients. Serum IGF-I SDS was similar among groups (approximately −1 SDS). IGFBP-3 SDS tended toward a gradient from P/P (−1.9) via P/N (−1.5) to N/N (−1.1), but IGF-I/IGFBP-3 ratio was normal in all groups. In P/P and P/N, mean head circumference SDS was >2 SD greater than mean height SDS. Children showed a progressive growth failure and bone age delay, delayed female pubertal onset and an initial low serum IGF-I, normal IGFBP-3 and low IGF-I/IGFBP-3 ratio. Conclusions P/P showed proportionate short stature with relative macrocephaly and relatively low IGFBP-3; P/N presented an intermediate pattern. P/N children were progressively short, showed delayed skeletal maturation, delayed puberty in girls and low IGF-I and IGF-I/IGFBP-3.

BACKGROUND: The association between caffeine with blood pressure (BP) still remains controversial. Caffeine is mainly metabolized by cytochrome-P450 (CYP)1A2 enzyme. Polymorphism of CYP1A2 is known to cause interindividual variation on enzymatic activity, thus affects caffeine metabolism and its effect on cardiovascular (CV) system.METHODS: We conducted a cross-sectional study and recruited 121 Indonesian subjects aged 25-60 years with varying coffee-drinking habits. DNA was extracted from peripheral blood and genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCRRFLP) technique. Blood pressures were measured in the morning prior to the daily activity. Caffeine concentration in blood plasma was measured using high-performance liquid chromatography (HPLC). The differences between variables were analyzed using MannWhitney analysis and the correlations among variables were determined using multivariate logistic regression analysis.RESULTS: This study showed that the frequencies of single nucleotide polymorphisms (SNPs) among Indonesian were 31.8%, 18.2%, 25.2% and 24.8% respectively for CYP1A2*1A, CYP1A2*1B, CYP1A2*1C and CYP1A2*1F alleles. The genotype analysis showed that the subject number of the wild type (*1A/*1A) and the variants were 9.92% and 90.08%. There were no significant differences in term of BP levels among CYP1A2 genotypes and coffee drinking habit groups.CONCLUSIONS: The frequencies of CYP1A2 SNPs in Indonesian are different with frequencies in other populations. Since the association were not statistically significant, CYP1A2 polymorphisms as the predictor of elevated blood pressuare should be investigated further.KEYWORDS: coffee, caffeine, blood pressure, single nucleotide polymorphism, CYP1A2

BACKGROUND: Current cancer drugs and treatments are aiming at eradicating tumor cells, but often are more toxic then effective, killing also the normal cells and not selectively the tumor cells. There is good personalized cancer therapy that involves administration to the cancer-bearing host of immune cells with direct anticancer activity, which called adoptive cell therapy (ACT). A review of the unique biology of T cell therapy and of recent clinical experience compels a reassessment of target antigens that traditionally have been viewed from the perspective of weaker immunotherapeutic modalities.CONTENT: Chimeric antigen receptors (CAR) are recombinant receptors which provide both antigen-binding and T cell-activating functions. Many kind of CARs has been reported for the past few years, targeting an array of cell surface tumor antigens. Their biologic functions have extremely changed following the introduction of tripartite receptors comprising a costimulatory domain, termed second-generation CARs. The combination of CARs with costimulatory ligands, chimeric costimulatory receptors, or cytokines can be done to further enhance T cell potency, specificity and safety. CARs reflects a new class of drugs with exciting potential for cancer immunotherapy.SUMMARY: CAR-T cells have been arising as a new modality for cancer immunotherapy because of their potent efficacy against terminal cancers. They are known to exert higher efficacy than monoclonal antibodies and antibodydrug conjugates, and act via mechanisms distinct from T cell receptor-engineered T cells. These cells are constructed by transducing genes encoding fusion proteins of cancer antigen-recognizing single-chain Fv linked to intracellular signaling domains of T cell receptors.KEYWORDS: chimeric antigen receptor, CAR T cells, adoptive cell therapy, ACT, T cell receptor, TCR, cancer, immunotherapy

Lateks tanaman karet dipanen melalui proses penyadapan. Penyadapan dilakukan dengan cara mengiris kulit menggunakan pisau sadap dengan sistem tertentu. Produksi tanaman karet selain ditentukan oleh potensi genetik masing-masing klon juga sangat ditentukan oleh sistem eksploitasi. Dalam sistem eksploitasi, kualitas penyadapan berkaitan dengan luka kayu maupun konsumsi kulit yang memperpanjang umur ekonomis sehingga produksi karet dalam satu siklus dapat lebih tinggi. Konsumsi kulit yang terkendali mempengaruhi umur ekonomis karet menjadi lebih lama sehingga produksi karet satu siklus dapat lebih tinggi. Pada 10 tahun terakhir perusahaan perkebunan mengalami kesulitan mendapatkan penyadap terampil. Upaya mengatasi hal tersebut sangat diperlukan rancangan pisau sadap yang mampu mengendalikan konsumsi kulit dan luka kayu. Tim peneliti Balai Penelitian Sungei Putih sejak tahun 2016 telah berhasil merancang pisau sadap ergonomis yang diberi nama pisau sadap Bi-cut untuk penyadapan panel sadap bawah (BO). Berdasarkan hasil pengujian pisau tersebut dapat dilihat bahwa kecepatan penggunaan prototipe pisau sadap Bi-cut lebih lambat dibandingkan penggunaan pisau sadap konvensional yaitu sebesar 4.69 detik per pohon. Konsumsi kulit menggunakan pisau sadap konvensional lebih tebal yaitu sebesar 2,73 mm dibandingkan dengan pisau sadap ergonomis yaitu sebesar 1,40 mm, namun tidak berbeda nyata terhadap produksi lateks. Keunggulan pisau sadap Bi-cut ini adalah dapat mencegah pelukaan kayu dan tebal irisan sadapan lebih tipis. Bi-cut mampu menyadap satu panel sadap BO selama 7,74 tahun/panel sadapan atau sekitar 30,96 tahun selama siklus produksi.

Objectives Gut hormones, such as PYY and ghrelin, are associated with appetite control and obesity. Protein is thought to be the most satiating nutrient and could affect the production of several gut hormones. The purpose of the current study was to find the effect of breakfast with different protein composition on PYY, ghrelin, and ad libitum intake 4 h after breakfast. Results This clinical trial involves 22 obese women participants. Subjects were given three types of breakfast: low protein consumption (12.4% protein), medium protein (23.5% protein), and high protein (40.6% protein). PYY and ghrelin levels were measured at 0, 15, 60, 120, and 180 min after breakfast. Ad libitum meal was given 4 h after breakfast and measured after. This study found that there is no significant difference in PYY and ghrelin level at each measurement time between different type of breakfast. This study also found no significant difference of ad libitum energy intake between different type of breakfast. Trial registration ClinicalTrials.gov NCT03697486, 3 December 2018. Retrospectively registered

Penggunaan obat generik yang rendah disebabkan oleh kurangnya pengetahuan masyarakat mengenai obat generik. Hal tersebut dikarenakan kurangnya informasi tentang obat generik di kalangan masyarakat. Pendidikan sangat berpengaruh terhadap pengetahuan seseorang. Penelitian ini dilakukan untuk mengetahui pengaruh pemberian edukasi terhadap pengetahuan mahasiswa Universitas Muhammadiyah Purworejo tentang obat generik dan obat bermerek. Desain penelitian adalah One Group Pre-test Post-test. Responden diperoleh dari mahasiswa Universitas Muhammadiyah Purworejo sebanyak 58 orang. Seluruh responden menjalani pre-test dan post- test dengan menjawab 10 pertanyaan tentang obat generik dan obat bermerek. Pertanyaan yang diberikan mewakili 4 aspek pengetahuan tentang obat generik dan obat bermerek. Pada hari yang sama pemberian edukasi dilakukan berupa penyuluhan sebelum diadakan post-test. Data diuji secara statistik dengan tingkat kepercayaan 95% . Hasil menunjukkan perbedaan bermakna antara nilai post-test dengan pre-test dengan nilai p = 0,000 < 0,05 yang berarti Ho ditolak sehingga terbukti bahwa edukasi dapat meningkatkan pengetahuan mahasiswa Universitas Muhammadiyah Purworejo tentang obat generik dan obat bermerek.

Perusahaan yang sukses untuk mencapai tujuannya secara optimal adalah perusahaan yang mampu merumuskan strategi, dan mengimplementasikan strategi secara efektif dan efisien. Hal ini dapat diterapkan dengan knowledge management model menggunakan metode Fuzzy Screening System untuk menentukan kuadran kondisi perusahaan, Fuzzy Screening System adalah salah satu metode multicriteria decision making (MCDM) yang menyatukan informasi yang diberikan oleh berbagai ahli dari menejemen tingkat atas dan menengah, dengan studi kasus PT. Jakarta Teknologi Utama aplikasi yang dibuat ini diharapkan dapat mengetahui sampai mana pencapaian kinerja perusahaan. Aplikasi dibangun berbasis web dengan menggunakan bahasa pemrogram PHP dan database my SQL Server, pengguna dari aplikasi ini adalah admin yang berperan mengelola data utama, pimpinan yang berperan melihat proses akhir dan laporan dan karyawan yang berperan mengisi quisioner. Dari hasil pengujian dapat disimpulkan bahwa metode Fuzzy Screening System dapat memberikan hasil berupa kuadran kondisi perusahaan dalam bentuk mapping.

BACKGROUND: Atherosclerosis is a leading cause of vascular disease worldwide. During the past several decades, landmark discoveries in the field of vascular biology have evolved our understanding of the biology of blood vessels and the pathobiology of local and systemic vascular disease states and have led to novel disease-modifying therapies for patients. This review is made to understand the molecular mechanism of atherosclerosis for these future therapies.CONTENT: Advances in molecular biology and -omics technologies have facilitated in vitro and in vivo studies which revealed that blood vessels regulate their own redox milieu, metabolism, mechanical environment, and phenotype, in part, through complex interactions between cellular components of the blood vessel wall and circulating factors. Dysregulation of these carefully orchestrated homeostatic interactions has also been implicated as the mechanism by which risk factors for cardiopulmonary vascular disease lead to vascular dysfunction, structural remodeling and, ultimately, adverse clinical events.SUMMARY: Atherosclerosis is a heterogeneous disease, despite a common initiating event of apoB-lipoproteins. Despite of acute thrombotic complications, an adequate resolution response is mounted, where efferocytosis prevents plaque necrosis and a reparative scarring response (the fibrous cap) prevents plaque disruption. However, a small percentage of developing atherosclerotic lesions cannot maintain an adequate resolution response, which leading to the formation of clinically dangerous plaques that can trigger acute lumenal thrombosis and tissue ischemiaand infarction.KEYWORDS: atherosclerosis, oxidative stress, inflammation, efferocytosis, foam cells, thrombosis

BACKGROUND: The strong inverse association of plasma levels of high-density lipoprotein cholesterol (HDL-C) with coronary heart disease (CHD) found in human epidemiological studies led to the development of the ‘HDL-C hypothesis’, which posits that intervention to raise HDL-C will result in reduced risk of CHD. However, recent evidence has raised doubts about the hypotheses that elevating HDL-C is necessarily therapeutic. Genetic variations that associate with altered HDL-C do not strongly associate with altered cardiovascular disease risk.CONTENT: HDL-mediated cholesterol efflux from macrophage foam cells or measurements of the flux of cholesterol from macrophages to the liver and feces seem to correlate better with atherosclerotic burden than with HDL-C levels. Thus, it may be time to modify the HDL-C hypothesis to the ‘HDL flux hypothesis’, where intervention to promote cholesterol efflux and reverse cholesterol transport will reduce CHD risk, regardless of whether it affects plasma HDL-C levels. A deeper understanding of the complex biology of HDL metabolism and its relationship to reverse cholesterol transport and atherothromobotic events is urgently needed. This might lead to biomarkers of HDL flux and functionality that are more informative than simple measurements of HDL-C levels.SUMMARY: It is now clear from recent clinical trial and genetic studies that some approaches to raising HDL-C levels may have no effect on CHD. This suggests the need to evaluate HDL-C-raising therapies in different clinical populations, as well as therapies targeted toward HDL flux and function rather than simply HDL-C elevation. Perhaps moving from a focus on the HDL-C hypothesis to a focus on the HDL flux hypothesis will permit a biologically based reassessment of the optimal therapeutic approach to targeting HDL for reduction in cardiovascular risk.KEYWORDS: reverse cholesterol transport, cholesterol efflux capacity, HDL dysfunction, HDL particle size, HDL lipidomics, HDL proteomics

Besides unpredictable time and duration of flooding occurrence, low soil fertility has been another main agricultural issue at riparian wetland in Indonesia. The objective of this research was to determine the potential use of biochar in improving soil chemical properties, rice growth, and yields. Assessment on the effects of particle sizes (S) and application rates (R) of rice-husk biochar was executed through pot experiments in a greenhouse of Universitas Sriwijaya, Indonesia, from January to April 2017. The experiment was laid out in randomized block arrangement with three replications. S consisted of particle sizes ≤1 mm (S1) and > 1 mm (S). R consisted of application rates at 1 t ha-1 (R1), 2 t ha-1 (R2), 3 t ha-1 (R3), and 4 t ha-1(R). Rice growth, yield, and growth analysis were measured during vegetative and generative stage. Soil chemical properties were analyzed after harvesting. Results indicated that application of biochar increased soil pH but did not affect cation exchange capacity (CEC), and availability of major soil nutrients. During vegetative stage, biochar application increased relative growth rate (RGR) and net assimilation rate (NAR) but decreased leaf are ratio (LAR). R4 treatment significantly increased grain weight per panicle, number of filled spikelet, and weight of 1000 grains. Root and stem N content tended to be higher with biochar application. Application of biochar on riparian wetland soil exhibited some promising positive impacts on soil properties, growth, and yield of rice. However, a long term study on residual effects of biochar application in tropical riparian wetland needs to be pursued further for a more comprehensive understanding on this issue.

Floating culture system (FCS) is the only feasible way for crop cultivation during high and prolonged flooding period at riparian wetlands. Objective of this research was to evaluate growth and yield of chili pepper cultivated using three different FCS during high flooding period at tropical riparian wetland. Floating rafts were constructed using used plastic bottles. Dimension of the raft was 2m x 1m with load capacity of 60 kg m-2; therefore each raft can carry 120 kg dead weight of growing media and chili pepper grown on it. Chili pepper used was CK9856 variety. Three FCS treatments applied were: P1, with gunny sack layer placed at interface between water surface and growing media; P2, without gunny sack at the interface; and P3, bottom part of growing media was immersed in water at 2-3 cm depth. These treatments were compared to P0, conventionally cultivated chili pepper as control. Result of this study revealed that chili pepper cultivated using FCS (P1, P2, and P3) significantly outperformed those of conventionally cultivated (P0) as indicated by higher growth and yield. Among FCS treatments, P2 produced the highest marketable yield (248.9 g plant-1). Therefore, the P2 is recommended for cultivation of chili pepper by smallholder farmers at riparian wetlands during high and prolonged flooding period.

Shallow water table problem has lessened farmer’s interest in cultivating vegetables at riparian wetland in Indonesia. At present, riparian wetlands are mostly underutilized. Objective of this study was to evaluate tolerance of common bean (Phaseolus vulgaris) to shallow water table condition. Common bean variety of PV072 was used in this study. Research was conducted in Jakabaring, South Sumatra, Indonesia; from November 2016 to February 2017. Leaf and root growth or damage can be used as an indicator of stress tolerance in plants exposed to unfavorable soil conditions. Results of our study indicated that roots of common bean were unable to survive in water saturated condition below water table, but the plants were able to compensate for this constraint by increasing root biomass within aerobic substrate above water table. Moreover, after termination of shallow water table treatment, common bean was able to regrow their roots into the ex-saturated zone. Common bean plants produced marketable yield albeit limited rhizosphere space. Interestingly, the plants exposed to 24 days of shallow water table produced the highest yield. In conclusion, common bean can be considered as tolerant vegetable to shallow water table. It should be noted that bean leaf reached 90 percent and full size in less than 6 days and 9 days, respectively, after the young leaf was unfolded. Therefore, long term study on bean leaf growth and development requires measurement on sequential and multiple leaves. Also, nocturnal relative leaf expansion rate (RLER) was significantly faster than diurnal RLER.

Jajar legowo 4:1 cropping pattern has been adopted by rice farmers; however, there has been limited information on the comparison between internal and edge rows. In addition, the effects of timing and frequency of fertilizer applications on rice cultivated at riparian wetland also have to be understood. In this research, both single and split applications of fertilizer were employed. The single fertilizer applications were applied at 15 days after transplanting (DAT) (T1), 30 DAT (T2), 45 DAT (T3); and the split applications were 15+30 DAT (T4), 15+45 DAT (T5), 30+45 DAT (T6), and 15+30+45 DAT (T7). Results of this research indicated that crops in the edge rows produced higher leaf area index but those at internal rows produced higher dry weight biomass. Split fertilizer application to three times (T7) increased the weight of grains and number of filled spikelet but did not affect other shoot and root growth traits. Overall, fertilizer application increased leaf chlorophyll and nitrogen content. Jajar legowo 4:1 planting pattern and split fertilizer application to three times are recommended for increasing yield in rice cultivated at riparian wetlands.

Degradasi lahan akibat pengolahan tanah intensif secara terus menerus dapat menurunkan produksi pertanian. Penelitian ini bertujuan untuk mendapatkan pengaruh sistem olah tanah, pengaruh berbagai dosis pupuk N pada sifat kimia tanah, dan pengaruh antara sistem olah tanah dan residu N pada sifat kimia tanah tahun ke-29 dengan tanaman indikator leguminosa. Penelitian dilakukan di Politeknik Negeri Lampung mulai dari Mei 2016 sampai dengan November 2016. Penelitian menggunakan Rancangan Acak Kelompok dengan dua faktor. Faktor pertama adalah berbagai sistem olah tanah yang terdiri atas olah tanah intensif (OTI), olah tanah minimum (OTM), dan tanpa olah tanah (TOT). Faktor kedua adalah residu pupuk N (Urea) yang diberikan pada tanaman sebelumnya, yang terdiri atas 3 taraf, yaitu 0kg N/ha (N0), 100 kg N/ha (N1), dan 200 kg N/ha (N2). Perlakuan diulang empat kali. Peubah yang diamati yaitu pH, C-organik, Nitrogen total, P tersedia (H2O), kalium tersedia, dan bobot tajuk. Data di analisis dengan analisis ragam diikuti dengan uji BNT pada taraf α = 0,05. Hasil penelitian menunjukkan bahwa tidak terdapat interaksi antara sistem olah tanah dengan residu pupuk N. Tanpa olah tanah menghasilkan P tersedia tertinggi (10,713). Residu nitrogen dengan taraf dosis 200 kg N/ha menghasilkan pH terendah (5,980).

Duta merek adalah alat yang digunakan oleh perusahaan untuk menyalurkan informasi dan mengomunikasikan tentang produk. Citra merek adalah sebuah gambaran atau proyeksi konsumen tentang merek. Kesadaran merek adalah seberapa paham atau pengetahuan tentang suatu produk. Keputusan pembelian adalah tindakan untuk memilih dan mengambil keputusan untuk membeli suatu merek. Penelitian ini bertujuan untuk mempelajari pengaruh dari duta merek, citra merek dan kesadaran merek terhadap keputusan pembelian Under Armour di Jakarta. Populasi dalam penelitian ini adalah para pembeli produk Under Armour. Teknik pemilihan sampel yang akan digunakan pada penelitian ini adalah non-probability sampling. Data yang telah diperoleh dengan menggunakan kuesioner melalui googleform. Hasil dalam penelitian ini menunjukkan bahwa duta merek dan kesadaran merek memiliki pengaruh positif dan signifikan terhadap keputusan pembelian sedangkan citra merek memiliki pengaruh positif tetapi tidak signifikan terhadap keputusan pembelian. Brand ambassadors are tools used by companies to channel information and communicate about products. Brand image is a picture or projection of consumers about the brand. Brand awareness is how much you understand or know about a product. Purchasing decisions are actions to choose and make decisions to buy a brand. This study aims to study the influence of brand ambassadors, brand image and brand awareness on Under Armor purchasing decisions in Jakarta. The population in this study are the buyers of Under Armor products. The sampling technique used in this research is non-probability sampling. The data has been obtained by using a questionnaire via googleform. The results in this study indicate that brand ambassadors and brand awareness have a positive and significant influence on purchasing decisions while brand image has a positive but not significant effect on purchasing decisions.

The COVID-19 pandemic that occurred in Indonesia was an unprecedented disaster. This catastrophic condition occurs almost all over the world which has a big impact on the economy. DKI Jakarta Province as the nation's capital has become the epicenter or center for the spread of the virus. The current economic condition of society requires everyone to "survive". This community service has presented an entrepreneurship training activity for PT Mandiri Utama Ruslim employees who are affected by this pandemic condition so that they prepare themselves to start their business. The activity was carried out in the form of a webinar on entrepreneurship to prepare employees in the COVID-19 pandemic situation.This PKM program is in the form of entrepreneurship training in the New Normal Era with employees of PT Mandiri Utama Ruslim in Tangerang. Tarumanagara University as an entrepreneur campus that helps provide funds for the implementation of this community service activity. Pandemi COVID-19 yang terjadi di Indonesia merupakan bencana yang tidak pernah diduga sebelumnya. Kondisi bencana ini terjadi hampir di seluruh dunia yang membawa dampak besar bagi perekonomian. Provinsi DKI Jakarta sebagai ibukota negara telah menjadi episentrum atau pusat bagi penyebaran virus tersebut. Kondisi perekonomian masyarakat sekarang ini menuntut tiap orang untuk “bertahan hidup”. Pengabdian masyarakat ini telah menghadirkan suatu kegiatan pelatihan kewirausahaan bagi karyawan PT Mandiri Utama Ruslim yang terdampak akan kondisi pandemik ini agar mereka mempersiapkan diri untuk memulai usahanya. Kegiatan dilakukan berupa webinar tentang kewirausahaan untuk mempersiapkan para karyawan dalam situasi pandemi COVID-19. Program PKM ini berupa Pelatihan kewirausahaan dalam Era New Normal dengan kepada karyawan PT Mandiri Utama Ruslim di Tangerang. Universitas Tarumanagara sebagai kampus entrepreneur yang membantu penyediaan dana demi terselenggaranya kegiatan pengabdian masyarakat ini.

The purpose of this study was to determine the effect of entrepreneurship education, financial support on the entrepreneurial attitudes and entrepreneurial intentions from economics faculty students at private universities in West Jakarta. This study uses the Judgment sampling method. Research respondents were collected from 100 private university students who were previously distributed through an online questionnaire. Data analysis using SEM-PLS. In the results of research, education and financial support have an effect on entrepreneurial attitudes for entrepreneurship. Entrepreneurial attitude has an effect on entrepreneurial intentions. Tujuan penelitian ini adalah mengetahui adanya pengaruh dari pendidikan kewirausahaan, dukungan finansial kepada sikap kewirausahaan dan niat berwirausaha dari mahasiswa dan mahasiswi fakultas ekonomi pada perguruan tinggi swasta di Jakarta barat. Penelitian menggunakan metode Judgement sampling. Responden penelitian terkumpul dari 100 mahasiswa perguruan tinggi swasta yang sebelumnya disebarkan melalui kuisioner Online. Analisis data menggunakan SEM-PLS. Pada hasil penelitian pendidikan dan dukungan finansial berpengaruh pada sikap kewirausahaan untuk berwirausaha. Sikap kewirausahaan berpengaruh pada niat kewirausahaan.

The global economy is something that must always be considered. The growing economy and the increasing number of competitors, make various parties have to rack their brains so that their companies are not left behind and continue to lead. The purpose of this study was to determine the effect of perceived quality and perceived value on purchase intention mediated by perceived risk. This research method uses quantitative methods using 100 samples taken from buyers of OFFBEAT & CO products, this study uses a Likert scale and analysis using PLS as a tool in data processing. The results of this study indicate that perceived value, perceived quality and perceived risk have a positive and significant effect on purchase intention.Sumber Perekonomian global merupakan sesuatu yang harus selalu diperhatikan.Perekonomian yang semakin berkembang dan saingan yang menjadi semakin banyak, membuat berbagai pihak harus memutar otak agar perusahaannya tidak tertinggal dan terus memimpin. Tujuan penelitian ini adalah untuk mengetahui pengaruh perceived quality dan perceived value terhadap purchase intention yang dimediasi perceived risk. Metode penelitian ini menggunakan metode kuantitatif dengan menggunakan sampel yang berjumlah 100 yang diambil dari para pembeli produk OFFBEAT & CO, penelitian ini menggunakan skala likert dan analisis menggunakan PLS sebagai alat bantu dalam melakukan pengolahan data. Hasil penelitian dari penelitian ini menunjukkan bahwa perceived value, perceived quality dan perceived risk berpengaruh positif dan signifikan terhadap purchase intention.

BACKGROUND: The number of elderly population in the world keep increasing. In their advanced ages, many elderly face years of disability because of multiple chronic diseases, frailty, making them lost their independence. Consequently, this could have impacts on social and economic stability. A huge challenge has been sent for biomedical researchers to compress or at least eliminate this period of disability and increase the health span.CONTENT: Over the past decades, many studies of telomere biology have demonstrated that telomeres and telomere-associated proteins are implicated in human diseases. Accelerated telomere erosion was clearly correlated with a pack of metabolic and inflammatory diseases. Critically short telomeres or the unprotected end, are likely to form telomeric fusion, generating genomic instability, the cornerstone for carcinogenesis. Enlightening how telomeres involved in the mechanisms underlying the diseases’ pathogenesis was expected to uncover new molecular targets for any important diagnosis or therapeutic implications.SUMMARY: Telomere shortening was foreseen as an imporant mechanism to supress tumor by limiting cellular proliferative capacity by regulating senescence check point activation. Many human diseases and carcinogenesis are causally related to defective telomeres, asserting the importance of telomeres sustainment. Thus, telomere length assessment might serve as an important tool for clinical prognostic, diagnostic, monitoring and management.KEYWORDS: telomerase, cellular senescence, aging, cancer

Productivity and cropping intensity on non-tidal wetland in South Sumatra are considerably low and has been underutilized up to now. The majority of farmers in this ecosystem are smallholders with limited adoption capacity on introduced technologies and modern agricultural practices. The objectives of this research were (1) to comprehensively capture multidimensional constrains that restrained local farmers in increasing their agricultural productivity; and (2) to identify, assess, and develop substantially-relevant, financially-affordable, and socially-acceptable agricultural technologies and practices for smallholder farmers to increase productivity. This research was organized in three main activities: qualitative research employing Grounded Theory procedure, quantitative questionnaire-guided survey, and a series of laboratory and field experiments. The research results indicated that the main constraints in increasing productivity and cropping intensity on the non-tidal wetland in South Sumatra include (1) unpredictable flooding occurrence and low soil nutrients content (agronomic constraint), (2) low financial and technology adoption capacity of local farmers (economic constraint), and (3) public policy has not significantly escalated farmer’s motivation to increase food production (social and institutional constraint). This research suggests that multidimensional (technical, financial, ecological, and socio-cultural) approaches should be integrated in collective efforts for sustainably intensifying food production on the non-tidal wetland.

Compared to the normal tissues, cancer cells tend to have higher proliferation rate and often lost their ability to undergo apoptosis. In addition, cancer cells can separate themselves from their original tissue thus causing metastasis in other part of body. While undergoing program cell death, disordered cellular programming can happen. The main causes of this cellular programming anomaly are epigenetic and genetic alterations, which have been known as two separate mechanisms in carcinogenetic. A recent outcome of whole exome sequencing of thousands of human cancers has been the unexpected discovery of many inactivating mutations in genes that control the epigenome. These mutations have the potential to disturb the DNA methylation patterns, histone modifications, and nucleosome positioning, hence, the causing gene expression alternation. Genetic alteration of the epigenome therefore contributes to cancer just as epigenetic process can cause point mutations and disable DNA repair functions. Epigenetic mechanisms changes could cause genetic mutations, and genetic mutations in epigenetic regulators could cause epigenome changes. Knowing that epigenome play a major role in the hierarchy of gene control mechanisms suggests that mutations might have impact on multiple pathways related to cancer phenotype. This pinpoint the fact that recently, the way the genes are organized and controlled are suggested to be a relevant factor for human carcinogenesis.Keywords: cancer genetic, cancer epigenetic, oncogens, tumor suppressor genes, driver mutation, passenger mutation

The aim in this reseach is to find empirical evidence to finding the influence between leverage, liquidity, growth, and firm size towards firm performance. The reseach method used was purposive sampling with a total sample of 44 firms listed on the Indonesian Stock Exchange (IDX). The subject of this reseach is all manufacture companies that are listed in Bursa Efek Indonesia for the period of 2017 until 2019. The type of data used is secondary data. Application that is used in this reseach is Eviews 11. This reseach shown that there are no significant influence between liquidity and firm age towards firm performance, there are positive significant influence between growth and firm size towards firm performance, and there is negative significant influence between leverage towards firm performance. The implication of this research is the need for high quality management that will encourage the firm to improve its performance in order to be able to determine the right strategies to be able to compete and then to maintain its sustainability.

The purpose of this study was to examine whether the close environmental factors near students influenced their entrepreneurial intentions and was mediated by individual entrepreneurial orientation in students of the Management Department, Faculty of Economics and Business, Tarumanagara University. Using descriptive research methods processed with SmartPLS 3.3.2. The number of samples used in the study were 121 student respondents who had taken entrepreneurship courses. The results showed that individual entrepreneurial orientation mediated the relationship between environmental factors near students and entrepreneurial intentions, but the stigma of entrepreneurial failure had no effect on entrepreneurial intentions. Tujuan dari penelitian ini adalah untuk menguji apakah faktor lingkungan dekat mahasiswa berpengaruh terhadap niat berwirausaha mereka dan di mediasi oleh orientasi kewirausahaan individu pada mahasiswa/i Jurusan Manajemen Fakultas Ekonomi dan Bisnis Universitas Tarumanagara. Menggunakan metode penelitian deskriptif yang diolah dengan SmartPLS 3.3.2. Jumlah sampel yang digunakan dalam penelitian sebanyak 121 responden mahasiswa yang telah mengambil mata kuliah kewirausahaan. Hasil penelitian menunjukan bahwa orientasi kewirausahaan individu memediasi hubungan antara faktor lingkungan dekat mahasiswa dengan niat berwirausaha, tetapi stigma tentang kegagalan kewirausahaan tidak berpengaruh terhadap niat berwirausaha.

The purpose of this research is (1) To study the Entrepreneurship Orientation research on the Financial Performance of MSME Businesses in the City of Bogor. (2) To determine the effect of Entrepreneurship Education on Financial Performance of MSME Businesses in the City of Bogor. The sample was selected using a quantitative method chosen by 80 respondents who owned an MSME business in Bogor City. The results show a positive and significant commitment to financial business on business performance and entrepreneurship education supporting a positive and significant impact on MSME business performance in Bogor City.Tujuan dari penelitian ini adalah (1) Untuk mengetahui pengaruh dari Orientasi Kewirausahaan terhadap Kinerja Finansial Bisnis UMKM di Kota Bogor. (2) Untuk mengetahui pengaruh dari Edukasi Kewirausahaan terhadap Kinerja Finansial Bisnis UMKM di Kota Bogor. Sampel dipilih menggunakan metode kuantitatif berjumlah 80 responden pemiliki usaha UMKM di Kota Bogor. Hasil menunjukan orientasi kewirausahaan secara langsung berpengaruh positif dan signifikan terhadap kinerja finansial bisnis dan edukasi kewirausahaan berpengaruh positif dan signifikan terhadap kinerja finansial bisnis UMKM di Kota Bogor.

Seed priming has been widely used to improve seedling vigor of several crops such as corn, wheat, and rice. Seed priming with zinc to increase seedling tolerance on submergence stress had never been evaluated. The objective of this research was to identify agronomical and physiological characteristics of several rice genotypes during seedling stage at submergence stress following zinc priming treatment. This research used factorial randomized block design with three replications. The first factor was rice genotypes and second factor was zinc solution of ZnSO4.7H2O. Seeds were soaked with Zn solution at different concentrations namely 0, 2.5, dan 5.0 mM respectively for 24 hours. After that the seeds were germinated on soil media in side the plastic box. Fourteen days-old seedling were submerged in water for 5 days and then return to normal condition for recovery. Parameters being observed included seedling dry weight, shoot carbohydrate, and leaves chlorophyl which were measured after 10 days of recovery. Seedling height was measured once a week from 2nd to 4th week. Results showed that intolerant genotypes to submergence stress grew faster but seedling dry weight, shoot carbohydrate and leaves chlorophyll content were lower compared to those tolerant genotypes. Local and national varieties which were not tolerant to submergence stress could be improved by priming treatment with 5.0mM zinc.Keywords: abiotic-stress, seeds- priming

BACKGROUND: Exposure to welding fume in the workplace was associated with lung function disorders and occupational asthma. In this study, we determined lung function parameters in men workers exposed to welding fumes from heavy equipment manufacturer. This study is a preliminary study of biomonitoring program in worker exposed to welding fume as our main study. METHODS: A study with case-control design, random study, was conducted among welder (59 subjects) and non-welder (34 subjects) with more than one year experience in the same job task in a heavy equipment manufacturer. All subjects completed physical examination, informed consent, questionnaire and lung function status. Lung function status was measured by spirometer with vital capacity (VC), forced vital capacity (FCV), forced expiratory volume in one second (FEV 1 ) and ratio of FEV 1 /FVC as test parameters. Linear regression model was developed to identify the risk factor of lung function parameter status using age, working period and smoking status as variables. RESULTS: This study showed that there were significant lower VC, FVC and FEV 1 in welder than non-welder, but not difference in ratio of FEV 1 /FVC. However, there was no significant difference among welder from foundry and fabrication plan. By multivariate analysis, working period was found as a risk factor for lower parameters in lung function among welder. CONCLUSION: Lung function parameters status were significantly lower in welder than non-welder, and working period was the most important indicator for lung function status evaluation among welder. KEYWORDS: vital capacity, VC, forced vital capacity, FCV, forced expiratory volume in one second, FEV 1 , lung function, ratio of FEV 1 /FVC, working period

As the time for the Shopping Center grew Pasar Baru to be abandoned because of the many modern shopping centers that began to appear in Jakarta. This causes shopping centers to compete with visitors in a variety of ways, such as transactions as well as family recreation, entertainment venues, and can become Third Place in big cities like Jakarta. So that makes shopping centers that are old concept become quiet. The decline in visitors in Pasar Baru has an impact on the surrounding area Pasar Baru which makes it not as busy as before and looks like it was left behind. This is contrary to the condition Pasar Baru first. Though Pasar Baru has great potential. If you look around Pasar Baru ethnic diversity there is very thick, there are 3 ethnic groups that are very dominant there namely, Indian, Chinese and Betawi ethnic groups. And ethnic diversity there makes Pasar Baru rich in culture. Therefore the purpose of this research is to create a forum to accommodate cultural activities and be able to attract the interest of visitors Pasar Baru by including various theories such as Third Place, as for the method used, namely conducting studies, observations and distributing questionnaires, as well as studying various needs of the surrounding community and making programs in accordance with the results of the observation survey to adjust the needs of the surrounding community, therefore this program is expected to be a solution to the problem of decreasing visitors Pasar Baru and can be a third place for the community in around the area Pasar Baru. Keywords: culture, diversity, ethnicity Abstrak Seiring berkembangnya waktu pusat pembelanjaan Pasar Baru ditinggalkan dikarenakan banyaknya pusat perbelanjaan modern yang mulai bermunculan di Jakarta. Hal ini menyebabkan pusat perbelanjaan berlomba-lomba menarik pengunjung dengan berbagai cara, seperti tempat transaksi sekaligus juga sebagai rekreasi keluarga, menjadi tempat hiburan, dan dapat menjadi Third Place di kota-kota besar seperti Jakarta. Sehingga membuat pusat perbelanjaan yang berkonsep lama menjadi sepi. Penurunan pengunjung di Pasar Baru berdampak ke daerah sekitar Pasar Baru yang membuat tidak seramai dahulu dan terlihat seperti di tinggalkan. Hal ini bertolak belakang pada kondisi Pasar Baru dahulu. Padahal Pasar Baru mempunyai potensi besar. Jika dilihat di sekitar Pasar Baru keberagaman etnis di sana sangatlah kental dan terdapat 3 etnis yang sangat dominan yaitu, etnis India, Tionghoa, dan Betawi. kemudian keberagaman etnis di sana membuat Pasar Baru kaya akan kebudayaan. Oleh karena itu tujuan dari penelitian ini adalah menciptakan sebuah wadah untuk menampung kegiatan-kegiatan kebudayaan serta dapat menarik minat pengunjung Pasar Baru dengan memasukan berbagai teori seperti Third Place. Adapun metode yang dipakai yaitu melakukan studi observasi dan penyebaran kuesioner, serta mempelajari berbagai kebutuhan dari masyarakat sekitar dan membuat program-program yang sesuai dengan hasil survei observasi untuk menyesuaikan kebutuhan masyarakat sekitar. Maka dari itu program ini diharapkan dapat menjadi solusi untuk permasalahan menurunnya pengunjung Pasar Baru serta dapat menjadi Third place bagi masyarakat di sekitar kawasan Pasar Baru.

The purpose of this study is to investigate and analyze the effect of entrepreneurial orientation and market orientation on the performance of SME businesses in West Jakarta. This research was conducted by judgment sampling method. Researchers distributed questionnaires to 100 business owners in West Jakarta. Data analysis using SEM PLS analysis. The results of the analysis concluded that entrepreneurship orientation and market orientation influence SME business performance in West Jakarta. Tujuan penelitian ini adalah untuk mengetahui dan menganalisa pengaruh orientasi kewirausahaan dan orientasi pasar terhadap kinerja usaha UKM di Jakarta Barat. Penelitian ini dilakukan dengan metode judgement sampling. Peneliti menyebarkan kuesioner kepada 100 pemilik usaha di Jakarta Barat. Analsisi data menggunakan analisis SEM PLS. Hasil analisis menyimpulkan bahwa orientasi kewirausahaan dan orientasi pasar berpengaruh terhadap kinerja usaha UKM di Jakarta Barat.

The purpose of this study was to determine and analyze the effect of innovation, proactivity, business network risk taking on the performance of SME businesses in West Jakarta. Sampling of this research was conducted by judgment sampling method. Researchers distributed questionnaires to 100 business owners in West Jakarta. Data analysis using SEM PLS analysis. The results of the analysis concluded that innovation, proactive, risk taking and business networks influence the performance business of SME in West JakartaTujuan penelitian ini adalah untuk mengetahui dan menganalisa pengaruh inovasi, proaktif, pengambilan risiko jaringan usaha terhadap kinerja usaha UKM di Jakarta Barat. Pengambilan sampel penelitian ini dilakukan dengan metode judgement sampling. Peneliti menyebarkan kuesioner kepada 100 pemilik usaha di Jakarta Barat. Analsis data menggunakan analisis SEM PLS. Hasil analisis menyimpulkan bahwa inovasi, proaktif, pengambilan risiko dan jaringan usaha berpengaruh terhadap kinerja usaha UKM di Jakarta Barat

Background: The calcium in the artery was thought to be the result of the imbalance or dysregulation of the promoter and inhibitor cytokines influenced by various subclinical and clinical conditions. This study aimed to investigate the interaction between central obesity, as an early subclinical condition, also known as a chronic low grade inflammation condition and coronary artery calcium (CAC) in non-diabetic population including the underlying pathomechanisms of a CAC in the early stage of atherosclerosis.Materials and Methods: This was a cross-sectional pathway analysis study enrolling 60 central obesity non-diabetic men that underwent coronary calcium score scan, anthropometrics and biomarker assays.Results: There was a positive correlation between increasing free leptin index/adiponectin (FLI/A) ratio and CAC (r=0.297; p

This study was conducted with the aim of finding out whether there is an effect of social capital on the new venture creation with self-efficacy as a mediating variable. The subjects of this study were 40 students majoring in management at the Tarumanagara University Faculty of Economics and Business who have a private business with a business age under 5 years. The sampling method is done by purposive sampling method. This study uses data analysis with the Partial Least Square (PLS) approach in the form of the Smart-PLS application version 3.0. The findings show that social capital does not significantly affect new venture creation. However, there is an indirect effect of social capital on new venture creation through self-efficacy as a mediating variable. Penelitian ini dilakukan dengan tujuan untuk mengetahui apakah terdapat pengaruh modal sosial terhadap penciptaan usaha baru dengan efikasi diri sebagai variabel mediasi. Subyek penelitian ini adalah 40 mahasiswa jurusan manajemen Fakultas Ekonomi dan Bisnis Universitas Tarumanagara yang memiliki bisnis pribadi dengan usia bisnis dibawah 5 tahun. Metode pengambilan sampel dilakukan dengan metode purposive sampling. Penelitian ini menggunakan analisis data dengan pendekatan Partial Least Square (PLS) berupa aplikasi Smart-PLS versi 3.0. Temuan menunjukkan bahwa modal sosial tidak berpengaruh secara signifikan terhadap penciptaan usaha baru. Namun, terdapat pengaruh tidak langsung modal sosial terhadap penciptaan usaha baru lewat efikasi diri sebagai variabel mediasi.