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Abstract Objectives To measure growth-related changes in orbital volume from childhood to the late teenage years using cone-beam computed tomography (CBCT) scans. Methods This retrospective cohort study involved 65 (24 male, 41 female) healthy Caucasian children (ages 6–18 years) with existing serial craniofacial CBCT scans. CBCT scans were available for 292 orbits. Each orbit was transformed into a closed space with well-defined boundaries, and orbital volume was measured using manual segmentation. A novel statistical analysis was applied to extract the maximum amount of longitudinal information from the data. Intra- and inter-operator correlation coefficients were calculated from replications performed on a random subset of 10% of the sample. Results Orbital volume increased at a rate of 1–2% annually until the late teenage years. Intra- and inter-operator agreement between repeated measurements were >90%. Conclusions Orbital volume increases by 1–2% per year throughout childhood continuing until the late teenage years. This annual increase is large enough to be clinically relevant as it may lead to less-than-optimal long term surgical outcomes when reconstructive surgery for the pediatric anophthalmic socket is required.

In Islamic proceedings, more than any other measure, a distinction between judicial and thematic matters can help to facilitate a fair trial. Subjective matters are in the position of expressing an incident and incident, and in contrast, judicial matters consisting of law, legal rule, sources and valid Islamic fatwas and Judicial procedure in the general sense. According to the basic principle provided in the law, it is the duty of the litigants to present the matter and the judge has no right to intervene in this matter. Judicial matters are also within the exclusive duties of the judge and the maximum role of the litigants is to remind the judge and their actions are beyond their authority and power. Resolving the dispute by the judge and issuing a verdict by him, is basically subject to the separation of thematic matters from matters Judgment and order of matters is a matter of subject matter. Failure to separate judicial matters from thematic matters by judges, lawyers and experts on undesirable effects and problems such as delegating judgment to an expert, lack of proper oversight of the Supreme Court over the implementation of the law, issuing rulings outside the requested framework, and inappropriate interference of judges in matters. In this article, while comparatively analyzing thematic and legal matters in Imami jurisprudence and common law, the effects and benefits of separation between them will be stated, and criteria will be provided to distinguish legal matters from thematic ones in order to reduce the aforementioned possible effects using these findings

Prior to the 2011 Egyptian revolution, scholars would assess the state–society relations in Egypt in the age of globalization as ineffective, considering any change impossible. However, popular movements in the Middle East and the easy collapse of state indicated that the state–society relation was not passive. In an attempt to re-examine state–society relations, this research focuses on why and how the state–society relations in Egypt, which had been based on authoritarian hegemony, underwent rupture and crisis. Moreover, it tries to explain how the state has managed to deal with the transformation of civil society. The findings show that despite the state’s incomplete and reductionist approach to globalization, the decrease in the state control over economy, in public services and the increase in inequality crisis all have led to class divisions, unemployment, and inflation. The loss of the elements integral to state hegemony led to the emergence of discontented and insurgent political subjects, which made the state insist on its repressive, non-ideological, and undemocratic functions. Due to the weakness in reproducing its power in civil society and the failure to realize the change in the subject’s sensibility–behavior schemata, the state failed in the face of the immediate movement of people, and emerging sociopolitical forces overthrew the state with the help of new media facilities.

Recently, the most common tool to compensate for various organ defects is tissue transplantation with several problems involved. These problems have led to the rapid growth of tissue engineering with a designed tissue approach or organ substitute in the last decade. For this purpose, it is important to determine the tissue mechanical properties. In this study, to obtain the cartilage structural parameters, isotropic Pro-Hyper-Viscoelastic Mooney-Rivlin and Neo-Hooke are used. These model coefficients are obtained by reverse engineering methods and using a coupled finite element-optimization algorithm utilized unconfined stress relaxation tests with root-mean-square error (RMSE)) less than 0.036, 0.033 for Neo-Hooke and Mooney-Rivlin respectively. Using Neo-Hooke and Mooney-Rivlin models, the modulus of elasticity was 0.47 MPa and 0.44 MPa, and the shear modulus was 0.188 MPa and 0.184 MPa, respectively. The predicted tissue mechanical response obtained by the finite element model showed that the Mooney-Rivlin model is more consistent with the stress relaxation experiments than Neo-Hooke one. The results showed that during the stress relaxation test, by applying a compressing load on the sample, initially the fluid pressurization in the matrix pores has the most contribution in the load-bearing (total stress). When time elapses, the fluid contribution in the load-bearing decreases, and the solid matrix contribution increases.

The purpose of the present study is to predict the transient response of the human cornea via a structural model appropriately representing its biomechanical behavior. Load bearing characteristics of the cornea remain poorly understood due to the complexity of its constitutive model. A constitutive model that captures the response of cornea over the whole experimental time and incorporates all included nonlinearities is necessary. In the current study, parameters of the structural anisotropic fiber-reinforced hyper-viscoelastic model have been obtained using coupled finite element-optimization analysis and the uniaxial tensile test for three different strain rates. The utilized model accounts for the dispersion of the fibers along with their reorientation during loading, the nonlinear behavior of finite tissue deformation, and the intrinsic viscoelastic property of the matrix. Results show that the higher the strain rate the higher the stiffness of tested samples. Samples showed stiffening behavior specially at the end section of the tissue response for slower tensile rates. Eventually, the model behavior and its connection with its micro structures such as the collagen fibers, have been investigated. Examining the results shows that the numerical simulations performed for the prediction of the cornea tissue behavior are in agreement with the experimental results.

Background: In this study, an active orthosis has been designed to rehabilitate patients with weak wrist flexor and extensor muscles. Methods: First, the mechanical design of the actuating mechanism with a linear servo motor to provide the desired wrist rotation, is performed in SolidWorks software. Also, to determine the force created by the actuator during flexion and extension of the wrist, the movement of the mechanism is simulated in Visual Nastran software. After molding the patient's wrist, the main body of the orthosis is made by forming the thermoplastic sheets on the mold, and the components of the mechanical part of the mechanism are installed on it. Then, the hardware part of the electronic circuits to drive the motor and to communicate between the control modules and the actuator is designed. For the programming of microcontrollers and synchronizing of deriver to the joystick, Bascom AVR software is used. The simulation of electrical circuit is performed in Proteus software and the printed board circuit is made in Altium Designer software. Results: The results of applying this orthosis on the wrist of a healthy subject indicate its proper performance in creating an acceptable angle range for the wrist extension and flexion. Conclusion: The use of the designed active wrist orthosis can improve the rehabilitation process of the patients with weakness in their wrist muscles.

Ahmadinejad's rise to power in Iran's political structure was accompanied by a new round of economic policies. Iranian analysts have examined these policies from a variety of perspectives, while some believe that the economic orientation of this period was closely related to economic populism. Based on this, the main question of the preliminary research is that the economic policies of Mahmoud Ahmadinejad's presidential period are relative to the macroeconomics of populism? The present paper attempts, from the perspective of political economy, using Durran Bush and Edwards' macroeconomic popolism) in the form of a populist approach as a political strategy and at the level of economic policy-making) while revising Ahmadinejad's economic policies, an explanation of the relationship between these policies and populist approaches to the economy as well as its consequences for the economy of Iran. The research findings show that Ahmadinejad, on the basis of populist economic policy makers, promised to support his supporters of poverty and inequality and the revival of justice, he worked with oil revenues to implement expansionary economic policies in the first two years of his presidency. Which ultimately led to the spread of liquidity, inflation, and recession, after which, since 2009, due to lower oil revenues, the ninth government turned to stabilizing policies and reduced its subsidies and economic development plans.

Introduction: One of the most common types of spinal diseases is spondylolisthesis, which in advanced cases requires surgical intervention. This study aimed to compare the results of L4-L5-S1 and L5-S1 vertebral fusion treatment in high-grade L5-S1 spondylolisthesis. Methods: A study design that randomized controlled trial. A total of 70 consecutive patients who underwent surgery for the treatment of spondylolisthesis at Al-Zahra Hospital in Isfahan, Iran, were evaluated from July 2020 to February 2021 (35 patients underwent L4-L5-S1 and 35 received L5-S1 vertebral fusion treatment). The radicular and low back pain (LBP) intensity (Vanguard Australian Shares), blood loss, wound infection, reduction, and quality of life (SF-12 scores) were quantified before the surgery, 1, 3, and 6 months after surgery in two groups. Results: Patients involved in the two groups had similar baseline demographic characteristics. The percent slip in L4-L5-S1 and L5-S1 group, respectively, postoperative 81.11% and 57.89%, P = 0.0001. Intraoperative blood loss and postoperative were higher in the L4-L5-S1 group when compared to the L5-S1 group (P < 0.05). The wound infection rate of the L4-L5-S1 group was similar to that of the L5-S1 group (8.6% vs. 2.9%, P = 0.303). There was no difference in radicular and LBP intensity, SF-12 scores among patients with L4-L5-S1 and L5-S1 groups (P < 0.05). Conclusion: Both L4-L5-S1 and L5-S1 were equally beneficial in improving short-term functional outcomes for patients with high grade L5-S1 spondylolisthesis. However, L4-L5-S1 was associated with statistically significant higher incidences of blood loss, but it was accompanied by a better reduction. Therefore, caution should be exercised when considering L4-L5-S1.

Introduction: Occupational therapy and performing specific motor activities are among the healing processes for injured people that should be followed by patients in need after the doctor’s prescription. The objective of this study was to evaluate the effect of using virtual reality environments and interacting with hardware designed for the treatment and rehabilitation of patients with upper limb injuries. Method: In this study, the design and manufacturing process consisted of two parts: software and hardware. In the software section, in order to access the virtual reality environment under the Windows operating system, the virtual reality environment was designed and coded and then the connection to the hardware and microcontroller section of the Arduino board was provided so that commands could be exported from the controller to the virtual reality environment and depending on the mouse motion, a movement in the virtual environment would be made. Results: Given the nature of this research, the criteria proposed by Martilla and James were used to evaluate the software. Moreover, Numeric Pain Rating Scale (NRS) was used to measure the effect of this method on reducing pain and the performance of virtual reality environment in reducing pain was evaluated. Conclusion: The results showed that using virtual reality for rehabilitation, with accordance to the type of graphics provided and the hardware designed, in addition to reducing treatment time and pain level, encourages the patients to use the software and continue the activities in a place other than the clinic.

Introduction: Patients undergoing surgery may need transfusion of blood products for a variety of reasons. Therefore, this study aimed to determine the incidence of blood transfusion complications in patients undergoing surgery. Methods: The present study was performed as a cross-sectional study in 2020 at Shohadaye Tajrish Hospital in Tehran, Iran. A total of 1132 patients who had complications during surgery upon transfusion of blood and blood products from 2015 to 2020 were included in the census. To collect information, a checklist, including patients’ information, the type of product, and types of complications was used. SPSS software version 21 was used for data analysis. Results: In this study, 99.7% of the complications were acute, and in 91.1% of the cases, the severity of complications was mild. Of the confirmed complications, 46.4% were allergic reactions, and 43.8% were reported as non-hemolytic febrile reactions. A total of 91.1% of patients completely recovered after the onset of the complication, 6.2% had a partial disability, 0.4% had severe disability, and 0.3% died. Conclusion: The results showed that most patients had acute complications in terms of the type of complication and mild in terms of the severity, thus a completely regular program is recommended to control side effects related to blood and blood products transfusion.

To assess the diagnostic utility of glypican-3 (GPC-3) in comparison to Hep Par 1 in the diagnosis of liver tumours, a cross-sectional study involving 66 resected liver tumours were tested for the protein expression of these markers by immunohistochemistry using monoclonal antibodies. Of the 66 cases, 26 (39.4%) were hepatocellular carcinoma (HCC), 4 (6.1%) were intrahepatic cholangiocarcinoma and 36 (54.5%) were metastatic tumours. Hep Par 1 and GPC-3 expressions in HCC were 24/26 (92.3%) and 19/26 (73.1%) respectively. In contrast, of non-HCC cases, only 2/40 cases (5.0%) expressed Hep Par 1, including a metastatic colorectal adenocarcinoma and a metastatic gastric adenocarcinoma. GPC-3 was expressed in 3/40 cases (7.5%), i.e. a metastatic adenocarcinoma of unknown origin, a metastatic gastric adenocarcinoma and an intrahepatic cholangiocarcinoma. The sensitivity and specificity for Hep Par 1 were 92.3% and 95% respectively while that of GPC-3 was 73.1% and 92.5% respectively. GPC-3 is a useful marker in the diagnosis of HCC. However it is not superior to Hep Par 1 in its sensitivity and specificity. We recommend that it is utilized together with Hep Par 1 as a panel in the diagnosis of HCC. [ABSTRACT FROM AUTHOR]

Introduction: Using modern technologies like virtual reality in rehabilitation can promise a great movement in medical sciences as sometimes, these technologies shorten the path of reaching the goal. In the present study, a virtual reality environment with the ability of physical interaction was designed to test and measure the hand motion, and a sample of electronic equipment was presented alongside the virtual reality to help the patients requiring rehabilitation, so that they can use the special and unique feature of this technology for faster improvement and easier access to the exercises in every location, especially at home. Methods: The design and manufacturing processes were performed in two sections: software and hardware. In the software section, the connection to the hardware section and the available processors and sensors in this section was provided under Windows Operating System by designing the virtual reality environment and the required coding, by using the artificial intelligence available on the software, and by defining the movement conditions. Results: Software-wise and hardware-wise investigation and evaluation of the designed and manufactured equipment were performed according to the type of services provided to 5 patients based on the criteria proposed by Martilla and James involving the importance and performance indicators. The testing and evaluation performed based on these indicators showed the rate of user satisfaction with the provided services and equipment. Conclusions: The results obtained from this study showed that a new treatment method can be provided for rehabilitation by measuring the level and amount of the patient’s hand movement and transferring these movements to the virtual environment proportional to the real conditions. Thus, alongside traditional rehabilitation methods, this new method can be effective in the improvement and quicker return of the people in need of rehabilitation to normal conditions.

Infiltration is considered as one of the most important soil parameters in the design and evaluation of furrow irrigation systems. Water is infiltrated through the wetted perimeter when it reaches a given point in the furrow until it recedes. The depth of infiltrated water at a given point, therefore, is a function of opportunity time, wetted perimeter, and soil intake characteristics (Oyonarte et al., 2002). Thus, in-depth knowledge of how the initial (e.g. initial water content) and boundary conditions (such as water head and wetted perimeter) of a furrow can act on the infiltration process is essential. Previous studies show that cumulative infiltration in furrow irrigation is highly affected by the water head and initial water content. In furrow irrigation, water infiltration into the soil is two-dimensional, both vertically and laterally (Bautista et al. 2014). Gravity forces are dominant in vertical infiltration, while suction forces dominate horizontal/lateral infiltration. Suction forces largely depend on soil matric potential, which is a function of the soil texture and structure, and play an important role in soil moisture retention, sorptivity, essential for plant growth, and lateral infiltration. Knowledge of lateral infiltration and edge effect is essential for designing furrow irrigation systems because many researchers have found that more than 60% of total infiltrated water is through the side walls of furrows. Several studies have been carried out to determine how initial and boundary conditions may affect the cumulative and lateral infiltration in furrow irrigation, but the combined effect of water head and initial water content on infiltration process is not investigated yet. Therefore, the main objective of this study is to investigate the combined effect of various initial (i.e., irrigation interval or initial water content) and boundary (i.e., water level or the wetted perimeter) conditions on the cumulative and lateral infiltration.

The large-scale quantification of accurate evapotranspiration (ET) time series has substantially been developed in recent decades using automated approaches based on remote sensing data. However, there are still several model-related uncertainties that require precise assessment. In this study, the Surface Energy Balance Algorithm for Land (SEBAL) and meteorological data from the Global Land Data Assimilation System (GLDAS) were used to estimate long-term daily actual ET based on three endmember selection procedures: two land cover-based models, one with (WF) and the other without (WOF) morphological functions, and the Allen method (with the default percentiles) for 2270 Landsat images. Models were evaluated for 23 flux tower sites with four main vegetation cover types as well as different climate types. Results showed that endmember selection with morphological functions (WF_ET) generally performed better than the other endmember approaches. Climate-based classification assessment provided the clearest discrimination between the performance of the different endmember selection approaches for the humid category. For humid zones, the land cover-based methods, especially WF, appropriately outperformed Allen. However, the performance of the three approaches was similar for sub-humid, semi-arid and arid climates together; the Allen approach was therefore recommended to avoid the need for dependency on land cover maps. Tower-by-tower validation also showed that the WF approach performed best at 12 flux tower sites, the WOF approach best at 5 and the Allen approach best at 6, suggesting that the use of land cover maps alone does not explain the differences between the performance of the land cover-based models and the Allen approach. Additionally, the satisfactory error metrics results when comparing the EC estimations with EC measurements, with root mean square error (RMSE) ≈ 0.91 and 1.59 mm·day−1, coefficient of determination (R2) ≈ 0.71 and 0.41, and bias percentage (PBias) ≈ 2% and 60% for crop and non-crop flux tower sites, respectively, supports the use of GLDAS meteorological forcing datasets with the different automated ET estimation approaches. Overall, given that the thorough evaluation of different endmember selection approaches at large scale confirmed the validity of the WF approach for different climate and land cover types, this study can be considered an important contribution to the global retrieval of long time series of ET.

Abstract Background Covid‐19 has caused many complications for both the infected and those in need of medical care. This may be due to infection‐related prognosis worsening or the patients’ avoidance of referring to the hospital for fear of contracting the infection. The decline of acute referral to the ER of many significant conditions with severe results on both the well‐being and life‐expectancy is a serious concern. To address these concerns, we designed this study to evaluate the recent pandemic's impact on “in‐hospital mortality” caused by neurological disorders pre and postpandemic. Methods and material The inclusion criteria were any acute neurological condition and the consent of the patients eligible for our study. The definitions of all assessed conditions and the comorbidities are ICD‐10 based. Hypertension and diabetes mellitus, due to their high prevalence, were evaluated separately from other internal comorbidities. The total number of the enrolled patients was 1742, 671 of whom had been during the COVID‐19 pandemic, and 1071 had attended the ER during the prepandemic era. Results The overall mortality was significantly higher during the pandemic, and the covid infected had suffered higher mortality rates. (p‐value

Background: The main objective of this study is to design and produce a twolink active knee orthosis with 2 degrees of freedom to rehabilitate patients’ lower extremities in moving their feet. This study aimed to provide motor independence in patients with cerebrospinal cord injury, quadriceps and knee joint injuries in athletes, and deviation of the quadriceps angle in the elderly. Methods: The current research is an experimental method. We have tried, while eliminating a physiotherapist, to enable movement modification of organs that suffer from dynamics poverty and ensure an improved movement for injured organs. In order to reduce external fluctuations and turbulences and determine orthosis opening and closing angle, a DC motor with a helical gearbox and a PID controller was used. In addition, an Arduino microcontroller and a potentiometer were used for processing and angle determination, respectively, to provide minimum wiring and maximum accuracy and performance for the proposed orthosis. Results: In order to verify the mechanical parts of the proposed orthosis, three tests were performed with different angles without charging the orthosis. Conclusion: Results showed that the proposed orthosis admissibly tracked intended angles and had a proper weight and volume to provide safety and comfort for the foot and knee joint.

Today, with advancements of engineering sciences in the medical field, the use of robotic rehabilitation systems for treating motor disabilities has been widely considered. There are some robotic systems for mechanical rehabilitation and revival of motion pattern of stroke patients. In this research, the main purpose is to designing a new robotic system with one degree of freedom (DOF) to move lower legs of patient without any physiotherapist’s help during rehabilitation. For presented model of system, an optimal kinematic design according to the normal pattern of human motion has been performed. Also, the equations of motion for rehabilitation system have been extracted and the minimum torque of the actuator of the mechanism with solution of inverse dynamic problem has been obtained. In next step, the prototype of orthosis is fabricated and its function is tested on a healthy subject. The experiments show that the proposed device provides optimum simulated motion for the user. In addition, the results of test of heart beat indicate a significant reduction in heart rate and energy consumption of user during using orthosis system comparing to normal motion (without device).

Introduction: Hemangioma is the most common benign liver tumor which is usually asymptomatic. There is no consensus on how to deal with symptomatic hemangiomas during pregnancy. In this report, a case of a symptomatic giant Cavernous Hemangioma in a 39-year-old woman at four month of pregnancy is introduced. Case report: A 39-year-old woman (Gravida4, para3) with a 4-month pregnancy was referred to the hospital due to pain in the epigastria and right hypochondria and nausea and vomiting. In clinical examination, a massive lesion which covered the entire upper abdominal region was palpable. Since it was symptomatic, it was successfully removed by surgery during pregnancy and Hemangioma with size of 23.5 x 16.5 cm was removed. Conclusion: Successful surgical removal of such a giant hemangioma is rare during pregnancy.